CN119678933B - Sanitary insecticidal compound composition and application thereof - Google Patents
Sanitary insecticidal compound composition and application thereofInfo
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- CN119678933B CN119678933B CN202411880647.8A CN202411880647A CN119678933B CN 119678933 B CN119678933 B CN 119678933B CN 202411880647 A CN202411880647 A CN 202411880647A CN 119678933 B CN119678933 B CN 119678933B
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Abstract
The invention belongs to the technical field of sanitary insect disinfestation, and relates to a sanitary insect disinfestation compound composition and application thereof. The composition comprises a component A and a component B in a mass ratio of 20:1-1:10, wherein the component A is a methoxy acrylic ester compound shown in a formula I, and the component B is an organophosphorus insecticide. The binary composition solves the problem of resistance of sanitary pests to organic phosphorus, improves the control effect, reduces the application dosage, reduces the application irritation, and prolongs the lasting effect. The active component A is used as a lethal agent, has no cross resistance with organic phosphorus, has good lethal effect, has no repellency to sanitary pests, is widely applied to places such as hotels, schools, factories and farms, and has special effects on preventing and controlling the sanitary pests.
Description
Technical Field
The invention belongs to the technical field of sanitary insect disinfestation, and relates to a sanitary insect disinfestation compound composition and application thereof.
Background
In recent years, the field of detention, spraying and killing has the defect that mosquitoes and flies are difficult to thoroughly kill, the duration of the medicament is short or the medicament has no pain points such as duration, and the medicament application frequency is improved only by increasing the dosage when the medicament is applied, so that the resistance of the mosquitoes and the flies is obviously improved, the medicament application cost is increased in multiple, and the irritation of the medicament to the medicament application personnel is also increased. Thus, there is a need in the marketplace for new generation of leave-on spray agents to address these pain points.
Flupyroxystrobin is a first methoxy acrylate insecticide, which was discovered by the UK Imperial chemical industry company and developed by its inherited company Zhengda, and was a respiratory inhibitor of Qo mitochondria. Flupyroxystrobin has not been registered for use in hygienic pests, and the compound has the structural formula:
For a long time, organophosphorus pesticides are widely applied to the prevention and treatment of public health pests, and the long-term use of the pesticides inevitably leads the health pests such as mosquitoes, flies, cockroaches and the like to generate drug resistance to part of organophosphorus pesticides, so that the prevention and treatment effect of the pesticides can be greatly reduced, and particularly in southern China, the resistance rising speed is higher, and the prevention and treatment effect of the health pests can be greatly reduced.
In order to solve the dilemma, the novel piperic acid derivative pesticide compound I-72 and the organophosphorus pesticide are compounded, on one hand, the action mechanisms of the two are different, the compounding has no interactive resistance, the problem of the resistance of sanitary pests to organophosphorus can be solved, the application amount is reduced, on the other hand, the compound Flupyroxystrobin has small irritation, the safety of the pesticide application personnel is improved, and furthermore, the research shows that the two are compounded, the control effect on the sanitary pests can be improved, and the compound pesticide is a compound pesticide technology with good market prospect.
In recent years, the field of detention, spraying and killing has the defect that mosquitoes and flies are difficult to thoroughly kill, the duration of the medicament is short or the medicament has no pain points such as duration, and the medicament application frequency is improved only by increasing the dosage when the medicament is applied, so that the resistance of the mosquitoes and the flies is obviously improved, the medicament application cost is increased in multiple, and the irritation of the medicament to the medicament application personnel is also increased. Thus, there is a need in the marketplace for new generation of leave-on spray agents to address these pain points.
Disclosure of Invention
The invention aims to solve the technical problem of providing a sanitary insecticidal compound composition and application thereof aiming at the defects in the prior art.
In order to achieve the above purpose, the present invention adopts the following technical scheme:
The sanitary insecticidal compound composition comprises a component A and a component B in a mass ratio of 20:1-1:10, wherein the component A is a methoxy acrylic ester compound (Flupyroxystrobin) shown in a formula I, and the component B is an organophosphorus insecticide;
the component B is any one of dithiophosphate, phoxim, fenitrothion and methyl pyrimidine phosphorus. Preferably, the mass ratio of the component A to the component B in the composition is 10:1-1:2;
More preferably, the weight ratio of Flupyroxystrobin to phosphorus disulfide is preferably 1:1;
the weight ratio of Flupyroxystrobin to the phosphorus sesquioxide is preferably 2:1;
the weight ratio of Flupyroxystrobin to the pirimiphos-methyl is preferably 4:1;
the weight ratio of Flupyroxystrobin to fenitrothion is preferably 2:1.
The application of the sanitary insecticidal compound composition in the aspect of preventing and controlling sanitary pests.
The composition is suitable for corresponding areas through a local administration mode, and the sanitary pests are one or more of houseflies, city flies, big head chrysomyes, lucilia sericata, microcystis aeruginosa, liriomyza sativae, summer toilet flies, yuantoilet flies, red head blowflies and Funiu flies.
The local application mode refers to a retention spraying mode or a brushing mode.
The application fields comprise places such as hotels, schools, factories, farms and the like.
The sanitary insecticidal compound preparation comprises an active ingredient and auxiliary materials, wherein the active ingredient is the composition, and the active ingredient accounts for 2% -50% of the total weight of the preparation.
The auxiliary materials are one or more of dispersing agents, wetting agents, defoaming agents, antifreezing agents, preservatives, disintegrating agents, thickening agents, binding agents, phagostimulants, stabilizing agents, fillers and water.
The preparation formulation is wettable powder, water dispersible granules or suspending agent.
When the dosage form is wettable powder, the preparation comprises the following raw materials, by weight, 2% -50% of active ingredients, 1% -10% of dispersing agents, 1% -5% of wetting agents, 5% -10% of stabilizing agents, 5% -15% of phagostimulants and 100% of fillers.
When the dosage form is a water dispersible granule, the water dispersible granule comprises the following raw materials, by weight, 2% -50% of active ingredients, 1% -10% of dispersing agents, 1% -5% of wetting agents, 1% -10% of disintegrating agents, 0.1% -1% of binders, 5% -10% of stabilizing agents, 5% -15% of phagostimulants and fillers which are complemented to 100%.
When the dosage form is a suspending agent, the suspending agent comprises, by weight, 2% -50% of an active ingredient, 1% -10% of a dispersing agent, 1% -5% of a wetting agent, 0.3% -0.5% of a preservative, 0.5% -1.5% of a thickening agent, 0.1% -0.3% of a defoaming agent, 3% -5% of an antifreezing agent, 5% -10% of a stabilizing agent, 5% -15% of a phagostimulant and water which are complemented to 100%.
The dispersant is selected from one or more of polycarboxylate (for example TERSPERSE, manufactured by Henschel Co., USA), lignosulfonate, alkylbenzenesulfonate, naphthalene sulfonic acid formaldehyde condensate salt, alkylphenol ethoxylate, fatty alcohol ethoxylate, fatty amine ethoxylate, fatty acid polyoxyethylene ester, and glycerin fatty acid ester polyoxyethylene ether.
The wetting agent is selected from one or more of alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, henlsmei), naphthalene sulfonate (such as NNO), nekal BX, wetting penetrating agent F, sodium dodecyl benzene sulfonate and detergent LS.
The defoaming agent can be any one or a mixture of two or more of polydimethylsiloxane, diglycol ester, tributyl phosphate and dipalmitoyl ethylenediamine.
The antifreezing agent can be any one of ethylene glycol, propylene glycol, glycerol and urea, or a mixture of two or more of the above materials in any proportion.
The preservative is selected from any one or a mixture of two of potassium sorbate and sodium benzoate in any proportion.
The disintegrating agent is selected from one or more of ammonium sulfate, sodium bicarbonate and sodium carbonate, and the mixture is formed by mixing two or more of the above components according to any proportion.
The thickener is selected from one or more of xanthan gum, hydroxyethyl cellulose, methyl cellulose and magnesium aluminum silicate, and a mixture of two or more of the above materials at any ratio.
The binder is selected from one or more of dextrin, polyvinylpyrrolidone and sodium alginate, and a mixture of two or more of the above materials at any ratio.
The phagostimulant is selected from one or a mixture of two or more of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia mossambica powder, maltose, honey and milk essence in any proportion. The phagostimulant can be added into the sanitary composition to ensure that the application area is 20% -40% of the conventional application, and the application position is selected from the corner line of the wall surface 4, the top or the bottom corner line of the indoor room.
The stabilizer is selected from any one or a mixture of two or more of urea formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethyl piperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate and n-acylated alkyl alcohol amine according to any proportion. The stabilizer, when added to the sanitary composition, can cause the mortality rate of the sanitary composition to be more than 60% on the semi-absorption surface or the absorption surface for 30 days.
The filler is selected from one or a mixture of two or more of kaolin, clay, diatomite, bentonite, white carbon black, attapulgite, corn starch and light calcium carbonate in any proportion.
When the dosage forms are wettable powder, water dispersible granules and suspending agents, the preparation can be carried out according to a conventional method or an existing method in the field.
When the sanitary insecticidal composition or the preparation is used for preventing and controlling sanitary pests, the insecticidal composition or the preparation is diluted by 100-500 times by adding water and sprayed on the surfaces of walls, floors, doors and windows, ceilings, houses and the like in the application field, so that the contact surfaces of the sanitary pests can be knocked down and killed.
Compared with the prior art, the method has the following characteristics:
(1) Experiments show that Flupyroxystrobin and part of organophosphorus pesticides are compounded to have synergistic effect, on one hand, the environmental compatibility is good, the application amount is reduced, on the other hand, from the aspect of action mechanism, flupyroxystrobin and organophosphorus sanitary pesticides have different action mechanisms, no interactive resistance exists, the problem of resistance of sanitary pests to organophosphorus is solved, the control effect is improved, pesticide compounding of different action mechanisms of the two can also delay the drug resistance of the pests, the resistance control of the pests is facilitated, and better quick-acting and lasting effects can be shown on the semi-absorption surface or the absorption surface.
(2) Flupyroxystrobin has small irritation and improves the safety of the drug applying personnel, and moreover, the research shows that the compound drug can improve the control effect on sanitary pests, thereby being a compound drug technology with better market prospect.
(3) Aiming at the problems of persistence, poor killing effect of targets such as houseflies and the like, the persistence is solved by a formula technology, and the feeding mode of the houseflies is researched, and the feeding attractant is added, so that the houseflies increase licking frequency, and the medicine dosage ingested by the flies is improved.
Detailed Description
The following detailed description of the technical scheme of the present invention is provided, but the present invention is not limited to the following descriptions:
application example 1. Flupyroxystrobin and organophosphorus co-toxicity coefficient determination test target is housefly (Yangzhou local resistant housefly), adult on 3 rd to 4 th days after emergence, female and male halves;
The test method refers to GB/T26350-2010 fly biological assay of fly drug resistance detection method and NY/T1154.7-2006 pesticide 7 th part of pesticide indoor biological assay test criterion test insect test;
table 1Flupyroxystrobin determination of co-toxicity coefficient with dithiophosphate (against housefly)
As shown in Table 1, flupyroxystrobin and dithiophosphate are compounded in a ratio of 20:1-1:10, the co-toxicity coefficients of the compound pesticide against the houseflies are all larger than 120, and the synergistic effect is most obvious especially when the compounding ratio is 1:1.
Table 2Flupyroxystrobin determination of co-toxicity coefficient with Phosphothioate (against housefly)
As shown in Table 2, the co-toxicity coefficients of Flupyroxystrobin and the phoxim are all larger than 120 when the compounding ratio of Flupyroxystrobin to the phoxim is 20:1-1:10, and the synergistic effect is most obvious especially when the compounding ratio is 2:1.
Table 3Flupyroxystrobin optimal co-toxicity coefficient with other organophosphorus (against housefly)
As shown in Table 3, the optimal ratio of Flupyroxystrobin to other organic phosphorus is within the range of 10:1-1:2, and the synergistic effect is obvious.
The preparation method of the dosage form in each embodiment of the invention comprises the following steps:
The laboratory preparation method of the wettable powder comprises the steps of weighing the effective components, wetting agent, dispersing agent, stabilizing agent, phagostimulant and filler according to the proportion, adding the effective components, the wetting agent, the dispersing agent, the stabilizing agent, the phagostimulant and the filler into a mixer, uniformly mixing, and crushing the materials by an airflow crusher.
The laboratory preparation method of the water dispersible granule comprises the steps of weighing the effective components, wetting agent, dispersing agent, phagostimulant, disintegrating agent, stabilizing agent and filler according to proportion, adding the effective components, wetting agent, dispersing agent, phagostimulant, disintegrating agent, stabilizing agent and filler into a mixer, uniformly mixing, crushing by an airflow crusher, using the mixer again, adding a mixture of water and binder, extruding and granulating by a granulator, and drying by boiling, thus obtaining the water dispersible granule.
The laboratory preparation method of the suspending agent comprises the steps of weighing water, dispersing agent, wetting agent, antifreezing agent, thickening agent, preservative, phagostimulant, defoamer and stabilizer according to proportion, adding raw materials, shearing for 5min by a high-speed shearing machine, transferring to a sand mill, and grinding for 2-3h, wherein the particle size D90 is controlled below 5 mu m, thus obtaining the suspending agent.
The invention is illustrated below in connection with specific examples:
formulation example 1. 20% Flupyroxystrobin-dithiophosphate wettable powder
Flupyroxystrobin 10g, 10g of phosphorus disulfide, 5g of sodium dodecyl benzene sulfonate, 10g of calcium lignosulfonate, 15g of dimethyl disulfide, 5g of urea-formaldehyde resin and kaolin which are complemented to 100%.
Formulation example 2:30% flutyroxtyrosobin dithiophosphate water dispersible granule
Flupyroxystrobin 20g, 10g of phosphorus disulfide, 0.5g of nekal BX, 0.5g of sodium dodecyl sulfate, 1g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5g of fatty acid dimethyl disulfide ester, 5g of ammonium sulfate, 0.5g of dextrin, 5g of polyalkylene glycol and the balance of kaolin to 100 percent.
Formulation example 3 15% Flupyroxystrobin dithiophosphate suspension
Flupyroxystrobin 5g, 10g of phosphorus disulfide, 0.5g of alkyl calcium sulfonate, 0.5g of sodium dodecyl sulfate, 1g of polycarboxylic acid potassium salt, 4g of lignin calcium sulfonate, 0.5g of potassium sorbate, 1g of magnesium aluminum silicate, 0.5g of xanthan gum, 0.3g of polydimethylsiloxane, 5g of propylene glycol, 5g of polyacrylic acid, 5g of tilapia powder and water which are complemented to 100 percent.
Formulation example 4 50% Flupyruxystrobin-dithiophosphate water dispersible granule
Flupyroxystrobin 30g, 20g of phosphorus disulfide, 2g of nekal BX, 2g of dodecyl sodium sulfate, 2g of alkyl benzene sulfonic acid calcium salt, 8g of lignin sulfonic acid calcium salt, 12g of brown sugar, 3g of sodium sulfate, 1g of ammonium sulfate, 1g of polyvinylpyrrolidone, 6g of ethylene oxide-propylene oxide block polyether and the balance of kaolin to 100 percent.
Formulation example 5. 2% Flupyrox ystrobin. Dithiophosphate suspension
Flupyroxystrobin 1g, 1g of phosphorus disulfide, 0.5g of dodecyl sodium sulfate, 0.5g of alkyl calcium sulfonate, 0.5g of polycarboxylic acid potassium salt, 0.5g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of diglycol ester, 4g of glycol, 6g of ethyl acrylate, 5g of tilapia powder and water accounting for 100 percent.
Formulation example 6:14% Flupyruxystrobin-fenthion wettable powder
Flupyroxystrobin 12g, 2g of phosphorus sesquisulfate, 2g of sodium dodecyl sulfate, 6g of calcium lignosulfonate, 10g of brown sugar, 10g of white carbon black, 6g of vinyl acetate and the balance of diatomite to 100 percent.
Formulation example 7. 22% Flupyruxystrobin-fenthion Water dispersible granule
Flupyroxystrobin 20g, 2g of phosphorus sesquisulfate, 3g of sodium dodecyl sulfate, 2g of nekal BX, 5g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 10g of N-methylacetamide, 5g of sodium sulfate, 5g of sodium bicarbonate, 0.5g of polyvinylpyrrolidone, 0.5g of dextrin, 7g of tetramethyl piperidine amine, 6g of white carbon black and 100% of kaolin.
Formulation example 8:12% Flupyroxys trombin-phoxim suspension
Flupyroxystrobin 10g, 2g of phosphorus sesquisulfate, 2g of alkyl sulfonate, 1g of dodecyl sodium sulfate, 4g of polycarboxylic acid potassium salt, 6g of lignin sulfonate calcium salt, 0.5g of potassium sorbate, 0.5g of xanthan gum, 0.3g of tributyl phosphate, 3g of glycerol, 7g of sodium alginate propylene glycol ester, 15g of maltose and water which are added to 100 percent.
Formulation example 9:15% Flupyroxys trombin-phoxim suspension
Flupyroxystrobin 15g, 5g of phosphorus disulfide, 3g of sodium dodecyl sulfate, 1.5g of fatty acid polyoxyethylene ester, 4g of potassium polycarboxylate, 3g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of tributyl phosphate, 0.1g of dipalmitoyl ethylenediamine, 4g of ethylene glycol, 8g of methyl ethyl sulfonate, 6g of honey and water which are complemented to 100%.
Formulation example 10. 18% Flupyroxystrobin-phoxim wettable powder
Flupyroxystrobin 6g, 12g of phosphorus sesquisulfate, 5g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 2g of alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate, 2g of naphthalene sulfonic acid sodium salt, 1g of sodium dodecyl sulfate, 5g of fatty acid dimethyl disulfide ester, 10g of attapulgite, 7g of n-acylated alkanolamine and the balance of light calcium carbonate to 100 percent.
Formulation example 11 50% Flupyroxystrobin-phoxim wettable powder
Flupyroxystrobin 25g, 25g of phosphorus sesquioxide, 2g of fatty alcohol polyoxyethylene ether, 4g of lignin sulfonate calcium salt, 4g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 2g of phenethyl phenol polyoxyethylene ether phosphate, 5g of dimethyl disulfide, 10g of milk essence, 3g of white carbon black, 4g of urea-formaldehyde resin, 4g of polyalkylene glycol and the balance of diatomite to 100%.
Formulation example 12. 24% Flupyrxystrobin-methyl pyrimidine phosphorus wettable powder
Flupyroxystrobin 16g, 8g of methyl pyrimidine phosphorus, 0.5g of sodium dodecyl sulfate, 0.5g of alkyl benzene polyoxyethylene ether phosphate, 6g of lignin sulfonate calcium salt, 10g of anisaldehyde, 5g of N-methylacetamide, 9g of n-acylated alkanolamine and clay which are complemented to 100%.
Formulation example 13:40% Flupyrxystrobin-methyl pyrimidine phosphorus water dispersible granule
Flupyroxystrobin 30g, 10g of methyl pyrimidine phosphorus, 3g of detergent LS, 2g of sodium dodecyl sulfate, 4g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 6g of lignin sulfonic acid calcium salt, 10g of furanone, 5g of sodium carbonate, 1g of dextrin, 8g of sodium alginate propylene glycol ester, 20g of bentonite and 100% of corn starch. Formulation example 14:50% Flupyrxystrobin-methyl pyrimidine phosphorus suspending agent
Flupyroxystrobin 40g, 10g of methyl pyrimidine phosphorus, 2g of alkyl calcium sulfonate, 2g of wetting penetrating agent F, 1g of glycerin fatty acid ester polyoxyethylene ether, 4g of polycarboxylic acid potassium salt, 4g of lignin calcium sulfonate, 0.3g of sodium benzoate, 0.2g of magnesium aluminum silicate, 0.3g of carboxymethyl cellulose, 0.1g of tributyl phosphate, 5g of propylene glycol, 9g of sodium alginate propylene glycol ester, 5g of milk essence and water which are added to 100%.
Formulation example 15:16% Compound-methyl pyrimidine phosphorus water dispersible granule
Flupyroxystrobin 8g, 8g of methyl pyrimidine phosphorus, 2g of nekal BX, 3g of dodecyl sodium sulfate, 4g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5g of lignin sulfonic acid calcium salt, 10g of anisic aldehyde, 8g of sodium sulfate, 2g of sodium bicarbonate, 0.3g of polyvinylpyrrolidone, 0.5g of sodium alginate, 9g of sodium alginate propylene glycol ester, 10g of clay and 100% of kaolin.
Formulation example 16:12% Flupyrxystrobin-methyl pyrimidine phosphorus suspending agent
Flupyroxystrobin 4g, 8g of methyl pyrimidine phosphorus, 2g of dodecyl sodium sulfate, 2g of alkyl benzene polyvinyl ether phosphate, 3g of fatty amine polyoxyethylene ether, 4g of polycarboxylic acid potassium salt, 3g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 0.4g of potassium sorbate, 0.3g of hydroxyethyl cellulose, 0.2g of xanthan gum, 0.3g of polydimethylsiloxane, 4g of propylene glycol, 5g of tetramethyl piperidine amine, 5g of sodium alginate propylene glycol ester, 5g of honey and water which are complemented to 100%.
Formulation example 17 30% Flupyrxystrobin-methyl pyrimidine phosphorus wettable powder
Flupyroxystrobin 15g, 15g of methyl pyrimidine phosphorus, 6g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 2g of lignin sulfonic acid calcium salt, 3g of detergent LS, 1g of sodium dodecyl sulfate, 12g of N-methylacetamide, 5g of tetramethyl piperidine amine, 5g of sodium alginate propylene glycol ester and the balance of clay to 100 percent.
Formulation example 18:12% Flupyrxystrobin fenitrothion wettable powder
Flupyroxystrobin 8g, 4g of fenitrothion, 2g of sodium dodecyl sulfate, 1g of detergent LS, 5g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5g of lignin sulfonic acid calcium salt, 8g of N-methylacetamide, 7g of furanone, 5g of tetramethyl piperidine amine and the balance of clay to 100 percent.
Formulation example 19:30% Flupyroxystrobin fenitrothion water dispersible granule
Flupyroxystrobin 25g, 5g of fenitrothion, 2g of phenethyl phenol polyoxyethylene ether phosphate, 3g of sodium dodecyl sulfate, 3g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5g of lignin sulfonic acid calcium salt, 8g of dimethyl disulfide, 3g of sodium sulfate, 0.5g of sodium alginate, 5g of tetramethyl piperidine amine, 5g of sodium alginate propylene glycol ester and the balance of kaolin to 100 percent.
Formulation example 20. 2% Flupyrxystrobin-methyl pyrimidine phosphorus wettable powder
Flupyroxystrobin 1g, 1g of methyl pyrimidine phosphorus, 6g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 2g of lignin sulfonic acid calcium salt, 3g of detergent LS, 1g of sodium dodecyl sulfate, 12g of N-methylacetamide, 4g of sodium alginate propylene glycol ester, 4g of tetramethyl piperidine amine and the balance of clay to 100 percent.
Formulation example 21 16% Flupyroxystrobin fenitrothion suspension
Flupyroxystrobin 8g, 8g of fenitrothion, 8g of wetting penetrating agent F4 g, 1g of fatty alcohol polyoxyethylene ether, 4g of polycarboxylic acid potassium salt, 4g of lignin calcium sulfonate, 0.5g of sodium benzoate, 0.5g of methyl cellulose, 0.3g of polydimethylsiloxane, 4g of urea, 5g of sodium alginate propylene glycol ester, 5g of N-methylacetamide and water which are added to 100 percent.
Formulation example 22:45% Flupyroxystrobin fenitrothion water dispersible granule
Flupyroxystrobin 30g, 15g of fenitrothion, 3g of detergent LS, 1g of dodecyl sulfate sodium salt, 3g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 6g of lignin sulfonic acid calcium salt, 5g of dimethyl disulfide, 5g of sodium sulfate, 0.1g of polyvinylpyrrolidone, 5g of sodium alginate propylene glycol ester and kaolin which are complemented to 100 percent.
Formulation example 23:18% Flupyroxystrobin fenitrothion suspension
Flupyroxystrobin 6g, 12g of fenitrothion, 2g of sodium dodecyl sulfate, 4g of potassium polycarboxylate, 2g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 0.5g of potassium sorbate, 1.2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.3g of diglycol ester, 5g of propylene glycol, 5g of sodium alginate propylene glycol ester, 5g of n-acylated alkanolamine, 5g of milk essence and water which are added to 100%.
Formulation example 24. 2% Flupyruxystrobin-fenthion water dispersible granule
Flupyroxystrobin 1g, 1g of phosphorus sesquisulfate, 2g of sodium dodecyl sulfate, 3g of nekal BX, 5g of naphthalene sulfonic acid formaldehyde condensate sodium salt, 5g of N-methylacetamide, 1g of sodium sulfate, 2g of sodium bicarbonate, 0.5g of polyvinylpyrrolidone, 0.5g of dextrin, 5g of n-acylated alkanolamine, 5g of tetramethyl piperidine amine, 6g of white carbon black and kaolin which are complemented to 100%.
Formulation example 25:5% Flupyroxys trombin disulfide suspending agent
Flupyroxystrobin 4g, 1g of dithiophosphate, 3g of dodecyl sodium sulfate, 1.5g of alkylphenol ethoxylates, 4g of polycarboxylic acid potassium salt, 3g of naphthalene sulfonic formaldehyde condensate sodium salt, 0.4g of potassium sorbate, 0.7g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.2g of diglycol ester, 2g of ethylene glycol, 3g of propylene glycol, 5g of sodium alginate propylene glycol, 6g of tilapia powder and water which are complemented to 100 percent.
Application example II indoor efficacy test for controlling mosquito and fly
Test targets are female adults which are not bloodsucking on the 3 rd to 5 th days after the female adults are emerged, namely culex pallidum (local resistant mosquito species in Yangzhou);
Housefly (Yangzhou local resistant housefly), imago on 3 rd to 4 th days after emergence, male and female halves;
The test method refers to GB/T13917.1-2009, forced contact method;
Test surfaces, glass plates, varnished wood plates and gypsum plates;
dose setting, namely diluting the total concentration of the active ingredients of the preparation example to 200mg/L (the actual use is 400mg/L generally);
The control sample 1:50% of dithiophosphate emulsifiable concentrate (Jiangsu Gong Biotech Co., ltd.) is diluted to 200mg/L;
Control 2:500 g/L methyl pyrimidyl phospho emulsifiable concentrate (British front reaching Co., ltd.) was diluted to 200mg/L;
Test results:
table 4 examples of formulations efficacy test against mosquitoes and flies (glass plates)
Table 5 examples of formulations efficacy test against mosquitoes and flies (varnished wood board)
Table 6 example of formulation efficacy test against mosquitoes and flies (plasterboard)
The test results show that the dosage is reduced by half, and the drug effect difference among the medicaments can be obviously seen on the surface of the glass, and the drug effects of the preparation examples 1, 4, 8, 11, 14, 17 and 20 are better than those of the control sample 1 and the control sample 2 (see table 4);
The efficacy of the preparation example is reduced on the semi-absorption surface varnish board and the absorption surface gypsum board, and the part of the preparation is absorbed by the materials to reduce the components of the surface preparation, but the preparation example has better persistence from the efficacy data, the efficacy mortality of the varnish surface 30d can reach more than 75%, and the efficacy mortality of the gypsum surface 30d can reach more than 60%, which is superior to that of the control sample 1 and the control sample 2. (see Table 5, table 6).
Application example III phagostimulant application in preparation example drug efficacy determination
Test targets are houseflies (Yangzhou local resistant houseflies), adults on days 3-4 after emergence, and male and female halves;
the test method comprises the steps of adopting a glass square box with the diameter of 1.2 mm and the diameter of 1.2m, diluting the medicament, soaking the medicament in filter paper with the diameter of 20cm and the diameter of 20cm, airing the medicament, spreading the medicament in the glass square box, putting 30 flies into the glass square box, and observing the longest residence time and the contact frequency of the flies on the surface of the filter paper;
Test agent preparation 10, preparation 10 (with milk essence removed), preparation 20 (with N-methylacetamide removed);
dose setting, namely diluting the total concentration of the active ingredients to 200mg/L (400 mg/L is common in actual use);
TABLE 7 Effect of phagostimulants on the efficacy of houseflies
The test results show that the milk essence is added in the preparation example 11, the frequency of contacting the housefly with the medicament is improved, the medicament effect is relatively excellent, the N-methylacetamide is added in the preparation example 20, the residence time of the housefly on the surface of the filter paper is improved, the licking frequency of the housefly is increased, and the housefly can take more medicament, so that the final medicament effect is better (see table 7).
Application example IV drug efficacy comparison test for controlling housefly
Test target, housefly
The test method comprises the steps of selecting building walls of a farm as a tested object and partitioning, spraying a medicament on the surfaces of the walls, and recording the density reduction rate of flies after 1 day, 2 days and 3 days of each treatment group, wherein the area of a room of the farm is about 50m < 2 >, and the area of each wall is about 20m < 2 >.
Test treatment, wherein the preparation examples 2, 9, 17 and 24 are diluted by 100 times, and are sprayed on four corners of a wall and the ground respectively when being applied, the total area is 40%, and the dosage is 20mg of active ingredient/m 2;
Control sample 3, wherein the phagostimulant component is removed according to the formulation of the preparation example 2, and the preparation is diluted 100 times, and the dosage is 20mg of the active ingredient/m 2;
control sample 4, wherein the phagostimulant component is removed according to the formulation of preparation example 9, and diluted 100 times, and the dosage is 20mg of the active ingredient/m 2;
control sample 5, wherein the phagostimulant component is removed according to the formulation of preparation example 17, and diluted 100 times, and the dosage is 20mg of the active ingredient/m 2;
control 6, wherein the phagostimulant component is removed according to the formulation of the preparation example 24, and the preparation is diluted 100 times, and the dosage is 20mg of the active ingredient/m 2;
the control samples 3, 4, 5 and 6 were sprayed on the whole surface of the wall and the ground when applied;
table 8 formulation examples 2, 9, 17, 24 application treatments
| Treatment of | Application site | Administration mode |
| Formulation example 2 | Four corners of the wall with 20% of area | Retention spray |
| Formulation example 9 | Four corners of the wall with 40% of area | Retention spray |
| Formulation example 17 | Four corners of the wall with 20% of area | Retention spray |
| Formulation example 24 | Four corners of the wall with 40% of area | Retention spray |
| Control 1 | Monolithic wall, all applied | Retention spray |
| Control sample 2 | Monolithic wall, all applied | Retention spray |
| Control sample 3 | Monolithic wall, all applied | Retention spray |
| Control sample 4 | Monolithic wall, all applied | Retention spray |
Test results:
table 9 comparative test of efficacy of formulations examples 2, 9, 17, 24 against flies
| Treatment of | 1D Density reduction Rate | Rate of 2d density decrease | 3D Density reduction Rate |
| Formulation example 2 | 67.1% | 85.6% | 95.7% |
| Formulation example 9 | 66.3% | 89.7% | 96.8% |
| Formulation example 17 | 63.9% | 89.3% | 94.2% |
| Formulation example 24 | 65.6% | 90.2% | 98.7% |
| Control 1 | 58.5% | 79.4% | 86.5% |
| Control sample 2 | 53.5% | 79.9% | 83.3% |
| Control sample 3 | 52.5% | 78.3% | 85.8% |
| Control sample 4 | 56.3% | 80.1% | 86.2% |
As shown in Table 9, the invention changes the conventional passive control into active attractant attraction by adding the phagostimulant component, the application area is 20% and 40% of the conventional application, the application positions select four corners of the wall, the control effects of the preparation examples 2, 9, 17 and 24 on flies are obvious, the 1d density reduction rate is more than 80%, and the 3d density reduction rate is more than 94%, which are all better than the control samples 3,4, 5 and 6. The preparation examples 2, 9, 17 and 24 are added with the attractant component, and the fly is killed after gathering the attractant component and contacting the liquid medicine, so that the effect of preventing and controlling the fly by compounding Flupyroxystrobin added with the attractant component and the organophosphorus insecticide is better than that of a Flupyroxystrobin and organophosphorus insecticide compound composition without the attractant component, and the dosage of the composition is smaller than that of the composition without the attractant component.
The foregoing examples are merely illustrative of the technical concept and technical features of the present invention, and are not intended to limit the scope of the present invention. All equivalent changes or modifications made according to the essence of the present invention should be included in the scope of the present invention.
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