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CN119406454A - A phosphorus-containing porous organic polymer supported nickel catalyst and preparation method thereof - Google Patents

A phosphorus-containing porous organic polymer supported nickel catalyst and preparation method thereof Download PDF

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CN119406454A
CN119406454A CN202411305074.6A CN202411305074A CN119406454A CN 119406454 A CN119406454 A CN 119406454A CN 202411305074 A CN202411305074 A CN 202411305074A CN 119406454 A CN119406454 A CN 119406454A
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phosphorus
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杨尚东
杨瑾
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Lanzhou University
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Abstract

The invention relates to the technical field of catalysts, and particularly discloses a phosphorus-containing porous organic polymer supported nickel catalyst which is prepared from a Ni precursor and a phosphorus-containing porous organic polymer, wherein the mass fraction of Ni in the catalyst is 0.1% -10%, and the phosphorus-containing porous organic polymer is a random copolymer and has a structural general formula I, and a preparation method and application thereof. After the porous organic polymer containing the phosphorus ligand and the transition metal salt form the catalyst, the catalyst can be used for efficiently catalyzing and synthesizing the phosphorous acid diester compound, can be recycled after the reaction is finished, and can not obviously reduce the performance in the cyclic catalysis process.

Description

Phosphorus-containing porous organic polymer supported nickel catalyst and preparation method thereof
Technical Field
The invention belongs to the technical field of catalysts, and particularly relates to a phosphorus-containing porous organic polymer supported nickel catalyst and a preparation method thereof.
Background
In recent decades, porous organic polymers are widely applied to the fields of photoelectric conversion, gas adsorption and separation, catalysis, energy storage and conversion and the like due to the characteristics of high specific surface area, controllable pore structure, good chemical and thermal stability, easy surface functionalization and the like, and are emerging materials with great development potential. Among porous materials, scientists have first studied inorganic porous materials such as activated carbon, zeolite, porous silica, and the like. The material has larger specific surface area and higher porosity, so the material is widely used as a catalytic material and an adsorption separation material, but has the defects of single synthesis condition, difficult functionalization, poor preparation regulation and control and the like, so the application of the material is limited to a certain extent. The porous organic framework material is used as a supporting substrate, and is used for catalysis, because the porous organic framework material generally has special properties, such as high specific surface area, which can provide more catalytic sites for the catalytic reaction, on the other hand, the porous organic framework is insoluble in general solvents, thus playing an important role in metal recovery and recycling, and secondly, the porous organic framework is easy to modify, can accommodate various metals, functional groups or metal coordination sites, and enriches the diversity of the catalytic reaction. Under the background, in order to meet the continuous improvement of the requirements of the organic porous framework material and the continuous understanding of the structure of the organic porous framework material, the design and development of the functional porous organic framework material are of great significance.
Disclosure of Invention
The first object of the invention is to provide a porous organic polymer supported nickel catalyst containing phosphorus, which not only can be used for efficiently catalyzing and synthesizing a phosphorous diester compound, but also can be recycled after the reaction is finished, and the performance of the catalyst is not reduced in the cyclic catalysis process.
It is a second object of the present invention to provide a process for preparing the catalyst as defined above.
It is a third object of the present invention to provide the use of the above catalyst.
The aim of the invention is realized by the following technical scheme:
The phosphorus-containing porous organic polymer supported nickel catalyst is prepared from a Ni precursor and a phosphorus-containing porous organic polymer, wherein the mass fraction of Ni in the catalyst is 0.1% -10%, and the phosphorus-containing porous organic polymer is a random copolymer and has the following structural formula I:
In the general structural formula I, a is methylene of 0-5, m is the molar content of phosphorus-containing polymerized monomers, n is the molar content of comonomers, m is 1:0-100, but subscripts m and n do not represent the linking sequence of the monomers, the linking sequence of the monomers can be unfixed, the polymer is a random polymer, and R is
A monomer unit.
Preferably, the Ni precursor is selected from one or more of Ni(acac)2、NiCl2、Ni(PPh3)2Cl2、Ni(dppp)Cl2、Ni(dppf)Cl2、Ni(OTf)2、Ni(BINAP)Cl2、Ni(COD)2、Ni(OAc)2, preferably NiCl 2, and m: n is 1:1-20.
The preparation method of the phosphorus-containing porous organic polymer supported nickel catalyst comprises the steps of placing a Ni precursor and a phosphorus-containing porous organic polymer into a solvent under the protection of inert gas, stirring at 0-200 ℃ to enable the Ni precursor to be anchored on the phosphorus-containing porous organic polymer through coordination, and then removing the solvent to obtain the catalyst;
the phosphorus-containing porous organic polymer has the following structural general formula I:
in the structural general formula I, a is methylene of 0-5, m is the molar content of phosphorus-containing polymerized monomers, n is the molar content of comonomers, m is 1:0-100, and R is A monomer unit.
Preferably, the Ni precursor is selected from one or more of Ni(acac)2、NiCl2、Ni(PPh3)2Cl2、Ni(dppp)Cl2、Ni(dppf)Cl2、Ni(OTf)2、Ni(BINAP)Cl2、Ni(COD)2、Ni(OAc)2, the Ni loading mass fraction is 0.1% -10% based on the weight of the final catalyst, calculated according to the element Ni, the solvent is selected from n-hexane, dichloromethane, ethyl acetate, tetrahydrofuran, benzene and toluene, the stirring temperature is 25-100 ℃, the stirring time is 12-48h, and the inert gas is argon or nitrogen.
Further preferably, m is 1:1-20, the Ni precursor is NiCl 2, the Ni loading mass fraction is 0.1% -1% based on the weight of the final catalyst, the stirring time is 24-36h, the solvent is tetrahydrofuran or toluene, and the inert gas is argon.
Further, the preparation method of the polymer with the structural general formula I comprises the steps of under the protection of inert gas, functionalizing the vinyl phosphorus-containing polymer monomerDissolving the polymer and a comonomer based on a substituent R in tetrahydrofuran, adding a free radical initiator azodiisobutyronitrile, and stirring for reaction for 24-48 hours to obtain a polymer with a structural general formula I;
the comonomer based on substituent R is
Preferably, in the preparation method of the polymer with the general structural formula I, the molar ratio of the phosphorus-containing polymerized monomer to the comonomer based on the substituent R is 1:0-100, the molar amount of the azodiisobutyronitrile is 0.1-5% of the molar amount of vinyl in the raw material, the temperature of the stirring reaction is 60-150 ℃, and the inert gas is argon or nitrogen.
Further preferably, in the preparation method of the polymer with the structural general formula I, the molar ratio of the phosphorus-containing polymerized monomer to the comonomer based on the substituent R is 1:1-20, the temperature of the stirring reaction is 80-100 ℃, and the inert gas is argon.
Further, the preparation method of the phosphorus-containing polymerized monomer comprises the following steps:
Step 1, dropwise adding phosphorus trichloride into tetrahydrofuran containing (4-vinylphenyl) magnesium bromide under the stirring condition of 0 ℃, heating to room temperature, stirring for reacting overnight, extracting with ethyl acetate after quenching, removing solvent under reduced pressure, and separating by column chromatography to obtain a compound 1, wherein an eluent is petroleum ether and ethyl acetate mixed solution with the volume ratio of 50:1;
step 2, adding the compound 1, dibromoalkane and acetonitrile into a reactor, carrying out reflux stirring reaction for 24 hours at 90 ℃, adding methanol and 6M KOH after removing the solvent under reduced pressure, continuing the reflux stirring reaction for 24 hours, cooling, removing the solvent under reduced pressure, and separating by column chromatography to obtain a compound 2, wherein the eluent is methylene dichloride and methanol mixed solution with the volume ratio of 50:1;
And 3, under the protection of inert gas, adding the compound 2 into a reactor, adding toluene for dissolution, dropwise adding trichlorosilane, refluxing and stirring at 110 ℃ for reaction for 12 hours, then adding 2M NaOH for quenching, extracting with ethyl acetate, removing the solvent under reduced pressure, separating by column chromatography to obtain the compound 3, wherein the eluent is petroleum ether and ethyl acetate mixed solution with the volume ratio of 50:1, and thus the vinyl functionalized phosphorus-containing polymer monomer can be obtained.
The application of the porous organic polymer supported nickel catalyst containing phosphorus in the catalytic synthesis of a phosphorous acid diester compound.
Compared with the prior art, the invention has the following advantages:
The porous organic polymer supported nickel catalyst containing the phosphorus ligand is used for efficiently catalyzing and synthesizing a phosphorous diester compound, has mild reaction conditions, can reach 94% of yield, is suitable for large-scale production, has practical value, can be recycled after the reaction is finished, has no reduction in performance in the cyclic catalysis process, can reduce the production cost, and adds a new catalyst for heterogeneous catalysis.
Drawings
FIG. 1 is a structural unit structure of a phosphorus-containing porous organic polymer supported nickel catalyst A in example 1;
FIG. 2 is a 1 H spectrum of vinyl functionalized phosphorus-containing polymerized monomer compound 3 in deuterated chloroform;
FIG. 3 is a 13 C spectrum of vinyl functionalized phosphorus-containing polymerized monomer compound 3 in deuterated chloroform;
FIG. 4 is a 31 P spectrum of vinyl functionalized phosphorus-containing polymerized monomer compound 3 in deuterated chloroform;
FIG. 5 is a 1 H spectrum of tris (4-vinylphenyl) phosphorus comonomer L3 in deuterated chloroform;
FIG. 6 is a 13 C spectrum of tris (4-vinylphenyl) phosphorus comonomer L3 in deuterated chloroform;
FIG. 7 is a 31 P spectrum of tris (4-vinylphenyl) phosphorus comonomer L3 in deuterated chloroform;
FIG. 8 is a preparation route diagram of the phosphorus-containing porous organic polymer catalyst A in example 1;
FIG. 9 is an XRD characterization of the phosphorus-containing porous organic polymer catalyst A of example 1
FIG. 10 is a FT-IR characterization of a phosphorus-containing porous organic polymer catalyst A of example 1;
FIG. 11 is a BET characterization of the phosphorus-containing porous organic polymer catalyst A of example 1;
FIG. 12 is a pore size distribution plot of the phosphorus-containing porous organic polymer catalyst A of example 1;
FIG. 13 is an SEM characterization of a phosphorus-containing porous organic polymer catalyst A of example 1;
FIG. 14 is a TEM characterization of the phosphorus-containing porous organic polymer catalyst A of example 1.
Detailed Description
The following description of the preferred embodiments of the present invention is provided for the purpose of illustration and explanation only and is not intended to limit the present invention.
Unless otherwise indicated, the starting materials in the examples of the present invention were purchased commercially, e.g., an Naiji, piobtained, etc., from reagent companies, without further purification.
The preparation method of part of the products in the examples is as follows:
1. vinyl functionalized phosphorus-containing polymeric monomers The preparation method of (2) is as follows:
step 1, dropwise adding 20.0 millimoles of phosphorus trichloride into 40 milliliters of tetrahydrofuran containing 80.0 millimoles of (4-vinylphenyl) magnesium bromide under the condition of stirring at 0 ℃, heating to room temperature, stirring and reacting overnight, quenching, extracting with ethyl acetate, removing a solvent under reduced pressure, and separating by column chromatography to obtain a compound 1, wherein an eluent is petroleum ether and ethyl acetate mixed solution with the volume ratio of 50:1;
step 2, adding 10.0 mmol of compound 1, 20.0 mmol of dibromoalkane and 20 ml of acetonitrile into a reactor, carrying out reflux stirring reaction for 24 hours at 90 ℃, adding 10 ml of methanol and 6M KOH after removing the solvent under reduced pressure, continuing the reflux stirring reaction for 24 hours, cooling, removing the solvent under reduced pressure, separating by column chromatography to obtain compound 2, wherein the eluent is methylene dichloride and methanol mixed solution with the volume ratio of 50:1;
And 3, under the protection of inert gas, adding 1.0 millimole of compound 2 into a reactor, adding toluene for dissolution, dripping 24.0 millimole of trichlorosilane, refluxing and stirring at 110 ℃ for reaction for 12 hours, then adding 2M NaOH for quenching, extracting with ethyl acetate, removing the solvent under reduced pressure, separating by column chromatography to obtain compound 3, wherein the eluent is petroleum ether and ethyl acetate mixed solution with the volume ratio of 50:1, and thus the vinyl functionalized phosphorus-containing polymer monomer can be obtained.
2. Polymers of the general structural formula IThe preparation method of (2) is as follows:
under the protection of inert gas, vinyl functionalized phosphorus-containing polymeric monomer Dissolving the polymer with comonomer based on substituent R in tetrahydrofuran, adding free radical initiator azodiisobutyronitrile, stirring and reacting for 24-48h to obtain polymer with the general structural formula I, wherein the reaction formula is as follows:
The molar ratio of the phosphorus-containing polymerization monomer to the comonomer based on the substituent R is 1:0-100, preferably 1:1-20, the molar amount of the azodiisobutyronitrile is 0.1-5% of the molar amount of the vinyl in the raw material, the temperature of the stirring reaction is 60-150 ℃, preferably 80-100 ℃, the inert gas is argon or nitrogen, preferably argon, and the comonomer based on the substituent R is
In the general structural formula I, a is methylene of 0-5, m is the molar content of phosphorus-containing polymerized monomers, n is the molar content of comonomers, m is 1:0-100, preferably 1:1-20, but the subscripts m and n do not represent the linking sequence of the monomers, the linking sequence of the monomers can be unfixed and is a random polymer, and R is A monomer unit.
3. The preparation method of the phosphorus-containing porous organic polymer supported nickel catalyst comprises the following steps:
under the protection of inert gas, a Ni precursor and a phosphorus-containing porous organic polymer (polymer with a structural formula I) are placed into a solvent, and are stirred at a temperature of between 0 and 200 ℃ to enable the Ni precursor to be anchored on the phosphorus-containing porous organic polymer through coordination, and then the solvent is removed to prepare the phosphorus-containing porous organic polymer supported nickel catalyst.
The Ni precursor is selected from one or more of Ni(acac)2、NiCl2、Ni(PPh3)2Cl2、Ni(dppp)Cl2、Ni(dppf)Cl2、Ni(OTf)2、Ni(BINAP)Cl2、Ni(COD)2、Ni(OAc)2, preferably NiCl 2, the Ni loading mass fraction is 0.1% -10%, preferably 0.1% -1% calculated according to the element Ni based on the weight of the final catalyst, the solvent is selected from n-hexane, dichloromethane, ethyl acetate, tetrahydrofuran, benzene, toluene, preferably tetrahydrofuran or toluene, the stirring temperature is preferably 25-100 ℃, the stirring time is 12-48h, preferably 24-36h, and the inert gas is argon or nitrogen, preferably argon.
Example 1
Mixing 0.9 g of vinyl functionalized phosphorus-containing polymeric monomer (namely compound 3) and 5.92 g of comonomer L3 under the protection of inert gas argon at room temperature, dissolving in 120m L g of tetrahydrofuran, adding 0.16 g of free radical initiator azodiisobutyronitrile into the solution, stirring for 2 hours, transferring the stirred solution to an autoclave with stirring, continuing stirring reaction, polymerizing for 24 hours under the protection of 100 ℃ and nitrogen by utilizing a solvothermal polymerization method, cooling the polymerized solution to the room temperature, and vacuumizing the solvent under the room temperature condition to obtain the phosphorus-containing organic polymer carrier. 62.8mg of nickel chloride is weighed and dissolved in 100.0ml of tetrahydrofuran solvent, 1.0 g of phosphorus-containing organic polymer carrier obtained by copolymerization is added, the mixture is stirred for 24 hours under the protection of inert gas argon at 25 ℃, and then the solvent is vacuumized under the room temperature condition, so that the multiphase phosphorus-containing porous organic polymer supported nickel catalyst A is obtained.
Example 2
In example 2, the procedure was followed in the same manner as in example 1, except that 5.92g of L1 comonomer was used instead of 5.92g of L3 comonomer. The obtained phosphorus-containing porous organic polymer in-situ encapsulation nickel catalytic material is denoted as a catalyst B.
Example 3
In example 3, the procedure was followed in the same manner as in example 1, except that 5.92g of the L2 comonomer was used instead of 5.92g of the L3 comonomer. The obtained phosphorus-containing porous organic polymer in-situ encapsulation nickel catalytic material is denoted as a catalyst C.
From the XRD characterization diagram of FIG. 9 and the SEM characterization diagram of FIG. 13, it can be seen that the phosphorus-containing porous organic polymer of the general structural formula I is a random copolymer, and micropores and mesopores exist in the pores, which is more beneficial to catalytic reaction.
Example 4
Taking the catalyst A in example 1 as an example, the reusability of the phosphorus-containing porous organic polymer in-situ encapsulated nickel catalytic material in the catalytic synthesis of diphenylethyl phosphite (which belongs to a phosphorous diester compound, and phosphorous diester [ (RO) 2 P (O) H ] is a main intermediate used in fine and industrial organophosphorus chemistry) is illustrated.
30Mg of the catalyst A prepared above was charged into a 10m L-reaction tube, and 0.0176g (0.2 mmol) of sodium hypophosphite, 0.122g (1.0 mmol) of phenethyl alcohol, 74uL (0.6 mmol) of trimethylacetyl chloride and 3.0mL of acetonitrile were added, and after sealing, the reaction was carried out after heating to 120℃and then reaction was carried out for 12 hours, to obtain diphenylethyl phosphite. After the reaction is finished, the reaction tube is cooled to room temperature, the solid catalyst is centrifugally separated, and is washed three times by methanol and distilled water respectively, and the dried catalyst is used for recycling. The reaction solution was added with triphenylphosphine as an internal standard and analyzed by nuclear magnetic yield. The reaction data for the catalyst reuse are shown in table 1. As can be seen from Table 1, the catalytic material prepared by the invention can be reused for five times, and the catalytic activity can be well maintained.
Table 1 reusability of catalyst a of example 1 in a reaction for the synthesis of diphenylethyl phosphite
Examples 5 to 18
In examples 5-18, the procedure was followed as in example 4, except that 1.0mmol of the different alcohol substrate was used instead of 1.0mmol of phenethyl alcohol. The reaction results for the different alcohol substrates are shown in Table 2. As can be seen from table 2, the catalyst prepared according to the present invention can be applied to the reaction of different alcohols, and exhibits excellent catalytic activity.
TABLE 2 catalytic Properties of catalyst A of example 1 in different alcohol substrates
The foregoing description is only a preferred embodiment of the present invention, and the present invention is not limited thereto, but it is to be understood that modifications and equivalents of some of the technical features described in the foregoing embodiments may be made by those skilled in the art, although the present invention has been described in detail with reference to the foregoing embodiments. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (10)

1.一种含磷多孔有机聚合物负载镍催化剂,其特征在于,所述催化剂是由Ni前驱体与含磷多孔有机聚合物制备而成,所述催化剂中Ni的负载量质量分数为0.1%-10%;所述含磷多孔有机聚合物为无规共聚物,其具有如下结构通式I:1. A phosphorus-containing porous organic polymer-supported nickel catalyst, characterized in that the catalyst is prepared from a Ni precursor and a phosphorus-containing porous organic polymer, the mass fraction of Ni loading in the catalyst is 0.1%-10%; the phosphorus-containing porous organic polymer is a random copolymer, which has the following structural formula I: 结构通式I中:a为0-5的亚甲基;m为含磷聚合单体的摩尔含量,n为共聚单体的摩尔含量,m:n为1:0-100;R为 单体单元。In the general structural formula I, a is a methylene group with a molar content of 0 to 5; m is the molar content of the phosphorus-containing polymer monomer; n is the molar content of the comonomer; m:n is 1:0 to 100; R is Monomer unit. 2.根据权利要求1所述的含磷多孔有机聚合物负载镍催化剂,其特征在于,所述Ni前驱体选自Ni(acac)2、NiCl2、Ni(PPh3)2Cl2、Ni(dppp)Cl2、Ni(dppf)Cl2、Ni(OTf)2、Ni(BINAP)Cl2、Ni(COD)2、Ni(OAc)2中的一种或多种,优选为NiCl2;m:n为1:1-20。2. The phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 1, characterized in that the Ni precursor is selected from one or more of Ni(acac) 2 , NiCl2 , Ni( PPh3 ) 2Cl2 , Ni(dppp) Cl2 , Ni(dppf) Cl2 , Ni(OTf) 2 , Ni (BINAP) Cl2 , Ni(COD) 2 , and Ni(OAc) 2 , preferably NiCl2 ; m:n is 1:1-20. 3.权利要求1或2所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,惰性气体保护下,将Ni前驱体和含磷多孔有机聚合物放入溶剂中,在0-200℃下进行搅拌,使Ni前驱体通过配位锚定在含磷多孔有机聚合物上,然后除去溶剂即可制得所述催化剂;3. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 1 or 2, characterized in that, under the protection of an inert gas, a Ni precursor and a phosphorus-containing porous organic polymer are placed in a solvent, stirred at 0-200° C., so that the Ni precursor is anchored on the phosphorus-containing porous organic polymer by coordination, and then the solvent is removed to obtain the catalyst; 所述含磷多孔有机聚合物具有如下结构通式I:The phosphorus-containing porous organic polymer has the following structural formula I: 结构通式I中:a为0-5的亚甲基;m为含磷聚合单体的摩尔含量,n为共聚单体的摩尔含量,m:n为1:0-100;R为 单体单元。In the general structural formula I, a is a methylene group with a molar content of 0 to 5; m is the molar content of the phosphorus-containing polymer monomer; n is the molar content of the comonomer; m:n is 1:0 to 100; R is Monomer unit. 4.根据权利要求3所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,所述Ni前驱体选自Ni(acac)2、NiCl2、Ni(PPh3)2Cl2、Ni(dppp)Cl2、Ni(dppf)Cl2、Ni(OTf)2、Ni(BINAP)Cl2、Ni(COD)2、Ni(OAc)2中的一种或多种;基于制得的最终催化剂的重量,按照元素Ni的量计算,Ni的负载量质量分数为0.1%-10%;所述溶剂选自正己烷、二氯甲烷、乙酸乙酯、四氢呋喃、苯、甲苯;所述搅拌的温度为25-100℃;所述搅拌的时间为12-48h;所述惰性气体为氩气或氮气。4. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 3, characterized in that the Ni precursor is selected from one or more of Ni(acac) 2 , NiCl2 , Ni( PPh3 ) 2Cl2 , Ni(dppp) Cl2 , Ni(dppf) Cl2 , Ni(OTf) 2 , Ni (BINAP) Cl2 , Ni(COD) 2 , and Ni(OAc) 2 ; the mass fraction of the Ni loading is 0.1%-10% based on the weight of the final catalyst obtained and calculated according to the amount of elemental Ni; the solvent is selected from n-hexane, dichloromethane, ethyl acetate, tetrahydrofuran, benzene, and toluene; the stirring temperature is 25-100°C; the stirring time is 12-48h; and the inert gas is argon or nitrogen. 5.根据权利要求4所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,m:n为1:1-20;所述Ni前驱体为NiCl2;基于制得的最终催化剂的重量,按照元素Ni的量计算,Ni的负载量质量分数为0.1%-1%;所述搅拌的时间为24-36h;所述溶剂为四氢呋喃或甲苯;所述惰性气体为氩气。5. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 4, characterized in that m:n is 1:1-20; the Ni precursor is NiCl 2 ; based on the weight of the final catalyst obtained, the mass fraction of Ni loading is 0.1%-1% calculated according to the amount of elemental Ni; the stirring time is 24-36h; the solvent is tetrahydrofuran or toluene; and the inert gas is argon. 6.根据权利要求3所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,所述结构通式I聚合物的制备方法为:惰性气体保护下,将乙烯基功能化的含磷聚合单体与基于取代基R的共聚单体溶于四氢呋喃中,加入自由基引发剂偶氮二异丁腈,搅拌反应24-48h,得到结构通式I聚合物;6. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 3, characterized in that the method for preparing the polymer of the general structural formula I is as follows: under the protection of an inert gas, a vinyl-functionalized phosphorus-containing polymer monomer is reacted with The comonomer based on the substituent R is dissolved in tetrahydrofuran, a free radical initiator azobisisobutyronitrile is added, and the mixture is stirred for reaction for 24-48 hours to obtain a polymer of the general structural formula I; 所述基于取代基R的共聚单体为 The comonomer based on the substituent R is 7.根据权利要求6所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,所述结构通式I聚合物的制备方法中,所述含磷聚合单体与基于取代基R的共聚单体的摩尔比为1:0-100;所述偶氮二异丁腈的摩尔用量为原料中乙烯基摩尔量的0.1%-5%;所述搅拌反应的温度为60-150℃;所述惰性气体为氩气或氮气。7. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 6, characterized in that, in the method for preparing the polymer of the general structural formula I, the molar ratio of the phosphorus-containing polymer monomer to the comonomer based on the substituent R is 1:0-100; the molar amount of the azobisisobutyronitrile is 0.1%-5% of the molar amount of vinyl in the raw material; the temperature of the stirring reaction is 60-150°C; and the inert gas is argon or nitrogen. 8.根据权利要求7所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,所述结构通式I聚合物的制备方法中,所述含磷聚合单体与基于取代基R的共聚单体的摩尔比为1:1-20;所述搅拌反应的温度为80-100℃;所述惰性气体为氩气。8. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 7, characterized in that in the method for preparing the polymer of the general structural formula I, the molar ratio of the phosphorus-containing polymer monomer to the comonomer based on the substituent R is 1:1-20; the temperature of the stirring reaction is 80-100°C; and the inert gas is argon. 9.根据权利要求6所述的含磷多孔有机聚合物负载镍催化剂的制备方法,其特征在于,所述含磷聚合单体的制备方法如下:9. The method for preparing a phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 6, characterized in that the preparation method of the phosphorus-containing polymer monomer is as follows: 步骤1:在0℃搅拌下,将三氯化磷滴加到含有(4-乙烯基苯基)溴化镁的四氢呋喃中,升温至室温后,搅拌反应过夜,淬灭后,乙酸乙酯萃取,减压除去溶剂,柱层析分离得化合物1,洗脱剂为体积比50:1的石油醚和乙酸乙酯混合液;Step 1: phosphorus trichloride was added dropwise to tetrahydrofuran containing (4-vinylphenyl)magnesium bromide under stirring at 0°C, the temperature was raised to room temperature, the reaction was stirred overnight, quenched, extracted with ethyl acetate, the solvent was removed under reduced pressure, and compound 1 was separated by column chromatography, the eluent was a mixture of petroleum ether and ethyl acetate in a volume ratio of 50:1; 步骤2:将化合物1、二溴烷烃和乙腈加入反应器中,90℃下回流搅拌反应24h,减压除去溶剂后加入甲醇和6M KOH,继续回流搅拌反应24h,降温,减压除去溶剂,柱层析分离得化合物2,洗脱剂为体积比50:1的二氯甲烷和甲醇混合液;Step 2: Compound 1, dibromoalkane and acetonitrile were added to a reactor, and the mixture was stirred under reflux at 90°C for 24 hours. After the solvent was removed under reduced pressure, methanol and 6M KOH were added, and the mixture was stirred under reflux for 24 hours. The temperature was lowered, the solvent was removed under reduced pressure, and compound 2 was separated by column chromatography. The eluent was a mixture of dichloromethane and methanol in a volume ratio of 50:1. 步骤3:惰性气体保护下,将化合物2加入反应器中,加甲苯溶解,滴加三氯硅烷,110℃下回流搅拌反应12h,然后加2M NaOH淬灭,乙酸乙酯萃取,减压除去溶剂,柱层析分离得化合物3,洗脱剂为体积比50:1的石油醚和乙酸乙酯混合液,即可得到乙烯基功能化的含磷聚合单体。Step 3: Under the protection of inert gas, compound 2 is added into the reactor, toluene is added to dissolve it, trichlorosilane is added dropwise, and the reaction is refluxed and stirred at 110°C for 12 hours, and then 2M NaOH is added to quench, ethyl acetate is extracted, the solvent is removed under reduced pressure, and compound 3 is separated by column chromatography. The eluent is a mixture of petroleum ether and ethyl acetate in a volume ratio of 50:1, and a vinyl-functionalized phosphorus-containing polymer monomer can be obtained. 10.权利要求1所述的含磷多孔有机聚合物负载镍催化剂在催化合成亚磷酸二酯化合物中的应用。10. Use of the phosphorus-containing porous organic polymer-supported nickel catalyst according to claim 1 in catalytic synthesis of phosphite diester compounds.
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CN121134702A (en) * 2025-11-18 2025-12-16 淄博天丹化工有限公司 Phosphorous acid production methods
CN121134702B (en) * 2025-11-18 2026-01-30 淄博天丹化工有限公司 Process for producing phosphorous acid

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