CN119075801A - Pipeline connector and installation method thereof, mixer - Google Patents

Abstract

The present disclosure relates to a pipe connection and a method of installing the same, a mixer, the pipe connection including a main body portion including a first side configured to face an internal pipe of a mixing chamber of the mixer main body and a second side opposite the first side, the second side configured to face an end of a liquid inlet pipe, a first section extending from the first side of the main body portion for connection with the internal pipe, a second section extending from the second side of the main body portion for connection with the liquid inlet pipe, and a fluid passage extending through the main body portion, the first section, and the second section, the fluid passage including a first flow passage and a second flow passage in fluid communication, the first flow passage configured to be in fluid communication with the internal pipe, the second flow passage configured to be in fluid communication with the liquid inlet pipe, wherein an inner diameter of the first flow passage is smaller than an inner diameter of the second flow passage.

Description

Pipeline connecting piece, mounting method thereof and mixer

Technical Field

The present invention relates to a pipe connection and a method for its installation, and a mixer, in particular a jet mixer, comprising such a pipe connection.

Background

The mixer is a critical component required for the preparation of the emulsion and/or lipid nanoparticle solution. By forcing the pre-formed liquids into a mixing chamber of the mixer, a jet of liquid is formed which causes mutual impingement, thereby forming a stable emulsion and/or lipid nanoparticle solution.

The formation of the jet is generally achieved by a sudden drop in the cross-sectional dimensions of the fluid channel. It is known to use a fitting assembly to fluidly connect a feed line with a mixing chamber of a mixer, however, in order to achieve a change in cross-sectional dimensions, at least two fittings are required for fixing the feed line and for forming a small cross-section fluid channel, respectively, which results in a small cross-section fluid channel length that is too long, a large pressure drop of the fluid within the channel, and a low jet pressure.

In addition, the position of the jet exit is difficult to adjust, and the installation and processing difficulties of a plurality of joints are also greater.

Therefore, a pipeline connecting piece, an installation method thereof and a mixer comprising the pipeline connecting piece are needed, the defects of the prior art are effectively overcome, stable and reliable liquid jet flow is provided, the sealing performance is good, the installation is simple and reliable, and the preparation efficiency and quality of the mixer are improved.

Disclosure of Invention

In view of the above-mentioned problems and needs, the present invention provides a novel connection mechanism, and a switch including the same, which solves the above-mentioned problems and brings about other technical effects due to the following technical features.

In one aspect, the invention provides a conduit connection for a mixer comprising a mixer body for mixing fluids flowing from different liquid inlet conduits into different internal conduits through their respective conduit connections, the conduit connection comprising a body portion comprising a first side configured to face an internal conduit of a mixing chamber of the mixer body and a second side opposite the first side, the second side configured to face an end of a liquid inlet conduit, a first section extending from the first side of the body portion for connection with the internal conduit, a second section extending from the second side of the body portion for connection with the liquid inlet conduit, and a fluid passage extending through the body portion, the first section and the second section, the fluid passage comprising a first flow passage and a second flow passage in fluid communication, the second flow passage being configured to be in fluid communication with the internal conduit, the first flow passage being in fluid communication with the first flow passage, and the second flow passage being configured to be in fluid communication with the second flow passage.

According to the characteristics, the pipeline connecting piece provided by the invention does not need to be provided with a plurality of connecting joints for fixing the liquid inlet pipeline and forming the small-section fluid channel respectively, so that the pipeline connecting piece can be very small in size and can be directly arranged between the liquid inlet pipeline and the internal pipeline of the mixing chamber, and two sides of the main body part face the internal pipeline of the mixing chamber of the mixer and the end part of the liquid inlet pipeline respectively, thereby greatly reducing the installation size, having compact structure and saving the manufacturing and processing cost.

In some examples, the length L of the first section is determined according to the following formula:

Wherein k is equal to a distance between two of the plurality of internal conduits of the mixing chamber of the mixer body, d is equal to a desired correlation distance, and wherein k is greater than d.

According to the above feature, the length L of the first section may be adjusted according to the desired correlation distance. For conventional mixer junctions, the ends of the feed lines abut the internal lines of the mixing chamber and do not extend into the internal lines, and therefore, in general, the correlation distance of the different fluids in a conventional mixer is fixed and equal to the distance between the two internal lines. In the present invention, however, the pipe connection proposed by the present invention allows a closer correlation distance of the mixer, since the first section extends into the internal pipe of the mixing chamber.

In some examples, the body portion, the first section, and the second section have a solid of revolution shape, and wherein an axial direction of the solid of revolution is parallel to an axial direction of the body portion, the first flow channel, and the second flow channel, and wherein a center of revolution of the solid of revolution is concentric with the body portion, the first flow channel, and the second flow channel.

According to the above feature, the concentric arrangement of the rotors ensures that the jet can be ejected concentrically. Impinging jets on the core is critical for the formation of stable lipid nanoparticles.

In some examples, the first section has a frustoconical shape with a maximum outer diameter on the first side, the first section maximum outer diameter being less than or equal to the diameter of the first side, and wherein the frustoconical angle is in the range of 0 to 45 degrees, and wherein the first section is connected to the internal conduit in such a way that the first section is at least partially inserted into the internal conduit, and/or,

The second section has a truncated cone shape with a maximum outer diameter at the second side, the second section maximum outer diameter being smaller than or equal to the diameter of the second side, and wherein the truncated cone has an inclination angle in the range of 0 to 45 degrees, and wherein the second section is connected to the liquid inlet line in such a way that the second section is at least partially inserted into the liquid inlet line.

The first section and/or the second section are/is provided with a truncated cone shape with gradually changing outer diameter, so that the outer surface of the first section or the second section is used for abutting against the corresponding end part, thereby realizing automatic centering.

In some examples, the maximum outer diameter of the first section is greater than the inner diameter of the inner conduit and the minimum outer diameter of the first section is less than the inner diameter of the inner conduit, and/or,

The maximum outer diameter of the second section is larger than the inner diameter of the joint of the liquid inlet pipeline and the second section, and the minimum outer diameter of the second section is smaller than the inner diameter of the joint of the liquid inlet pipeline and the second section.

The above features represent a number of alternative embodiments. For example, the maximum outer diameter of the first section may be greater than the inner diameter of the inner conduit, while the minimum outer diameter of the first section may be less than the inner diameter of the inner conduit, so that the side wall of the first section will press against the inner wall of the inner conduit and self-centering is achieved by the adaptive fit of the rotors, thereby ensuring that the ejected fluid is concentric with the inner conduit. Similarly, the maximum outer diameter of the second section may be greater than the inner diameter of the connection of the inlet conduit to the second section, while the minimum outer diameter of the second section may be less than the inner diameter of the connection of the inlet conduit to the second section, again ensuring that the injected fluid is concentric with the inlet conduit.

In alternative embodiments, the first and second sections of the tubing connector may meet the above dimensional characteristics simultaneously, thereby ensuring that the injection fluid is concentric with the inner and inlet tubing. Alternatively, one of the first and second sections of the piping connection may meet the above dimensional characteristics, and the other may not. For example, the maximum outer diameter of the first section of the pipe connection may be less than or equal to the inner diameter of the connection of the inner pipe with the first section, so that the first side of the body portion directly abuts the end of the inner pipe and the first section extends entirely into the inner pipe.

In some examples, the first flow passage extends through at least a portion of the first section, and wherein the second flow passage extends through the body portion and/or the second section, and at least partially to the first section.

According to the above feature, since the first flow channel extends through at least part of the first section and the first section extends from the first side facing the inner conduit, the exit position of the first flow channel may even enter the inner conduit compared to the prior art, thus providing a higher flexibility of the jet exit position and a higher design margin. Furthermore, the first flow channel extends only through a part of the first section, so that its length is also small.

In some examples, the ratio of the inner diameters of the first and second flow passages is in the range of 1/30 to 1.

In some examples, the length of the first flow channel is less than the length of the second flow channel.

In some examples, the length of the first flow channel is less than 1/6, 1/5, 1/4, 1/3, or 1/2 of the length of the second flow channel.

In some examples, a sloped or curved transition is employed between the first flow channel and the second flow channel.

According to the characteristics, the first flow channel and the second flow channel can adopt inclined planes or curved surface transition, so that unstable turbulence or vortex is prevented from being formed in a reducing area between the two flow channels, and the fluid can run more stably.

In some examples, the inner diameter of the second flow passage varies in the axial direction and the inner diameter of the second flow passage proximate the first end of the first flow passage is smaller than the inner diameter of the second flow passage distal the second end of the first flow passage.

According to the above feature, the inner diameter of the second flow passage may vary in the axial direction, or may be gradual, and the inner diameter near the first end of the first flow passage is smaller than the inner diameter far from the second end of the first flow passage. Thus, the fluid need not be pressurized intensively (possibly with local vortex formation) at abrupt changes in the first and second flow passage sections, but rather is pressurized gradually as the inner diameter of the second flow passage changes. Preferably, the first end of the second flow passage may have an inner diameter equal to the inner diameter of the first flow passage.

In some examples, a side of the second section remote from the second side is further provided with a slot extending from an end of the second section remote from the body portion for removing the pipe connection from the internal pipe.

According to the above feature, the second section is provided with a groove, for example a straight groove, to facilitate the removal of the pipe connection from the mixing chamber. This has significant benefits in practical use. In use, the tubing connector requires a tight or interference fit with the internal tubing of the mixing chamber, and therefore, after the feed-in tubing is removed from the internal tubing, the tubing connector may remain in the internal tubing and be difficult to remove. By providing a groove at the end of the second section, the pipe connection can be removed by extending a tool, such as a screwdriver, into the mixer.

In yet another aspect, the invention also provides a mixer comprising a mixer body comprising at least one internal pipe, a mixing chamber leading to the mixing chamber for mixing fluids entering the mixing chamber from the internal pipe, and a fitting pipe in one-to-one correspondence with and communicating with the at least one internal pipe, at least one feed pipe for introducing fluids from the outside in one-to-one correspondence with the at least one internal pipe, a pipe connection as described above, wherein a first side of the pipe connection faces the internal pipe and a second side faces an end of the at least one feed pipe, and a fastener configured to detachably connect the pipe connection and the at least one feed pipe to the fitting pipe.

In some examples, the fitting line includes a first portion having a cylindrical inner surface, a second portion having a frustoconical inner surface, and a third portion at least partially provided with internal threads, disposed in sequence along an axial direction, the first portion being in fluid communication with the internal line.

In some examples, the fastener includes a hollow first fastener that is sleeved outside the liquid inlet pipeline, at least a portion of the outer surface of the first fastener is in a truncated cone shape, and a hollow second fastener that is sleeved outside the liquid inlet pipeline, the second fastener being provided with external threads, wherein a distance between the first fastener and the internal pipeline is smaller than a distance between the second fastener and the internal pipeline, and wherein the second fastener is in threaded connection with the fitting pipeline such that a compression seal is provided between the first fastener and the pipeline connection.

In some examples, the assembly line, the internal line, the feed line, and the fastener are disposed concentrically.

In some examples, the mixer is a jet mixer. Jet mixers are commonly used to prepare emulsions or lipid nanoparticles and have wide application in the fields of food, chemical, biopharmaceutical and vaccine preparation. Taking lipid nanoparticles as an example, firstly, high-speed jet flow is formed by respectively pressurizing mRNA solution and liposome solution, and the high-speed jet flow is impacted in a mixing chamber of a jet flow mixer, so that severe turbulence is generated, the liposome and the mRNA can be fully mixed by the severe turbulence, and thus, the positively charged liposome can efficiently encapsulate and encapsulate the negatively charged mRNA to form the lipid nanoparticles through electrostatic adsorption, and the lipid nanoparticles can be produced in batch.

In some examples, an end of the at least one feed line is interference fit with the line connection.

In another aspect, the invention also provides a method of installing a pipe connector as described above to a mixer body of a mixer as described above, the method comprising connecting a second section of the pipe connector to an end of a feed pipe, fitting the fastener over the feed pipe, and detachably connecting the feed pipe with the pipe connector and fastener to the mounting pipe.

In some examples, the fitting line includes a first portion having a cylindrical inner surface, a second portion having a frustoconical inner surface, and a third portion at least partially provided with internal threads, the first portion being in fluid communication with the inner line, and wherein the fastener includes a hollow first fastener that fits over the fluid intake line, at least a portion of an outer surface of the first fastener being frustoconical, and a hollow second fastener that fits over the fluid intake line, the second fastener being provided with external threads, wherein a distance between the first fastener and the inner line is less than a distance between the second fastener and the inner line, and wherein the fitting the fastener over the fluid intake line includes fitting the first fastener and the second fastener over the fluid intake line, wherein removably connecting the fluid intake line with the line connector and fastener to the fitting line includes fitting the fastener and the fitting line with the first fastener and the second fastener in the axial direction, and inserting the fastener into the fitting line, and fitting the second fastener into the threaded portion.

In a further aspect the invention provides a method of installing a pipe connector for installing to a mixer body of a mixer as described above, the method comprising connecting a second section of a fitting connector to an end of a feed pipe, wherein the fitting connector is formed by the pipe connector cutting off a first section and at least a part of the body, fitting the fastener over the feed pipe, removably connecting the feed pipe with the fitting connector and fastener to the fitting pipe, removing the feed pipe with the fitting connector and fastener from the fitting pipe, removing the fitting connector from the feed pipe, connecting the second section of the pipe connector to the end of the feed pipe, and removably connecting the feed pipe with the pipe connector and fastener to the fitting pipe.

In some examples, the fitting line includes a first portion having a cylindrical inner surface, a second portion having a frustoconical inner surface, and a third portion at least partially provided with internal threads, the first portion being in fluid communication with the inner line, and wherein the fastener includes a hollow first fastener that fits over the fluid intake line, at least a portion of an outer surface of the first fastener being frustoconical, and a hollow second fastener that fits over the fluid intake line, the second fastener being provided with external threads, wherein a distance between the first fastener and the inner line is less than a distance between the second fastener and the inner line, and wherein fitting the fastener over the fluid intake line includes fitting the first fastener and the second fastener over the fluid intake line, wherein removably connecting the fluid intake line with the fitting connection and fastener to the fitting line includes fitting the fitting connection and the fastener with the second fastener in the axial direction, and inserting the second fastener into the threaded portion of the fitting line.

In some examples, removably connecting the inlet conduit with the conduit connector and fastener to the fitting conduit includes inserting the inlet conduit with the conduit connector and the first fastener, the second fastener into the fitting conduit in an axial direction, and threadably connecting the second fastener with a third portion of the fitting conduit.

Drawings

In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the drawings of the embodiments will be briefly described below, and it is apparent that the drawings in the following description relate only to some embodiments of the present disclosure, not to limit the present disclosure.

FIG. 1 illustrates a perspective view of a plumbing connection according to at least one embodiment of the present disclosure;

FIG. 2 shows a side view of the embodiment shown in FIG. 1;

FIG. 3 illustrates a cross-sectional view of a mixer body according to at least one embodiment of the present disclosure;

FIG. 4 illustrates a partial cross-sectional view of a pipe connection mounted to a mixer in accordance with at least one embodiment of the present disclosure;

FIG. 5A illustrates a partial cross-sectional view of a piping connection piece mounted to a mixer according to another embodiment of the present disclosure;

FIG. 5B illustrates a partial cross-sectional view of a piping connection to a mixer according to an alternative embodiment of the present disclosure;

FIG. 6 illustrates a schematic cross-sectional view of a mixer in accordance with at least one embodiment of the present disclosure;

FIG. 7 illustrates a side view of a fitting connection according to at least one embodiment of the present disclosure;

Fig. 8A to 8D are views illustrating an installation process of a pipe coupling according to at least one embodiment of the present disclosure, wherein fig. 8A illustrates a view of a direct access of a liquid inlet pipe to an internal pipe, fig. 8B illustrates a view of an assembly coupling and a liquid inlet pipe to an internal pipe, fig. 8C illustrates a view of an untwisted front pipe coupling and a liquid inlet pipe to an internal pipe, and fig. 8D illustrates a view of a pipe coupling and a liquid inlet pipe to an internal pipe after being twisted;

FIG. 9 illustrates a schematic cross-sectional view of another mixer in accordance with at least one embodiment of the present disclosure;

FIG. 10A shows a schematic cross-sectional view of a joint assembly of the prior art;

Fig. 10B shows a schematic cross-sectional view of another prior art joint assembly.

Detailed Description

In order to make the objects, technical solutions and advantages of the technical solutions of the present disclosure more clear, the technical solutions of the embodiments of the present disclosure will be clearly and completely described below with reference to the accompanying drawings of specific embodiments of the present disclosure. Like reference numerals in the drawings denote like parts. It should be noted that the described embodiments are some, but not all embodiments of the present disclosure. All other embodiments, which can be made by one of ordinary skill in the art without the need for inventive faculty, are within the scope of the present disclosure, based on the described embodiments of the present disclosure.

Unless defined otherwise, technical or scientific terms used herein should be given the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The terms "first," "second," and the like in the description and in the claims, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a" or "an" and the like do not necessarily denote a limitation of quantity. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", etc. are used merely to indicate relative positional relationships, which may also be changed when the absolute position of the object to be described is changed.

Illustratively, the present disclosure describes embodiments of the present disclosure with jet mixers as examples. The present disclosure is not limited thereto, and the pipe connection proposed by the present disclosure is equally applicable to other mixers in the art, such as homogenizers, venturi mixers, gas-liquid mixers, lobe mixers, and the like

Various embodiments according to the present disclosure will be described in detail with reference to the accompanying drawings. Here, it is to be noted that in the drawings, the same reference numerals are given to constituent parts having substantially the same or similar structures and functions, and repeated description thereof will be omitted.

Possible implementations within the scope of the present disclosure may have fewer components, have other components not shown in the drawings, different components, differently arranged components, differently connected components, etc., than the examples shown in the drawings. Furthermore, two or more of the components in the figures may be implemented in a single component or a single component shown in the figures may be implemented as multiple separate components without departing from the concepts of the present disclosure.

The mixer is a critical component required for preparing the emulsion and/or lipid nanoparticle solution for mixing fluids flowing from different feed lines into different internal lines through their respective corresponding line connections. By forcing the pre-formed liquids into a mixing chamber of the mixer, a jet of liquid is formed which causes mutual impingement, thereby forming a stable emulsion and/or lipid nanoparticle solution.

The formation of the jet is generally achieved by a sudden drop in the cross-sectional dimensions of the fluid channel. As shown in fig. 10A, it is known to employ a fitting assembly to fluidly connect the inlet line 201 with the internal line 301 of the mixing chamber of the mixer 300. To form the jet, it is necessary to make a large difference between the cross-sectional dimensions of the pipe connected to the mixing chamber and the cross-sectional dimensions of the mixing chamber, in particular, to make the former much smaller than the latter (for example, 1/5 of the latter). In order to achieve a change in cross-sectional dimensions, at least two connectors are required, a first connector 101 and a second connector 102 as shown in fig. 10A, for fixing the liquid inlet pipeline 201 and for forming the small-section fluid channel 103, respectively, which results in an excessively long length of the small-section fluid channel 103, a larger pressure drop of the fluid in the channel, and a lower jet pressure.

In addition, the position of the jet exit is difficult to adjust, and the installation and processing difficulties of a plurality of joints are also greater.

On the other hand, as shown in fig. 10B, another form of fitting assembly is to directly connect the inlet line 200 to the mixer 500 through the fitting 400 and in fluid communication with the interior line 501 of the mixing chamber. However, in order to meet the jet requirements, the feed line 200 needs to be thin enough, resulting in a very high pressure and velocity of the fluid within the feed line 200, inevitably increasing the power and price of the fluid pump.

Therefore, there is a need for a pipe connection and a mixer comprising the same that effectively addresses the shortcomings of the prior art, provides a stable and reliable liquid jet, and improves manufacturing efficiency and quality. Furthermore, the method of installation of the piping connection is also critical to the performance of the mixer.

In view of the shortcomings of the prior art, the present disclosure proposes a pipe connection for a mixer and a mixer. The invention also provides a method for installing the pipeline connecting piece. The pipeline connecting piece is directly in fluid communication with the internal pipeline of the mixing chamber of the mixer and the liquid inlet pipeline, stable jet flow can be realized without an additional joint, and the structure is simple and reliable.

Exemplary embodiments of the pipe connection, the mixer, and the method of installing the pipe connection of the present disclosure will be described below with reference to fig. 1 to 8D.

Referring first generally to fig. 3 and 6, the mixer 100 comprises a mixer body 2, which may have a generally cylindrical shape, and in which a mixing chamber 21 is provided, the mixing chamber 21 may comprise two internal pipes 22 and one outlet pipe 23 opposite each other for connecting the respective inlet and outlet pipes 3 and 4, respectively. The two internal pipes 22 are 180 ° different from each other and the outlet pipe 23 is located between the two internal pipes 22 and 90 ° different from the two internal pipes, respectively. Fig. 3 is merely exemplary, and the included angle between the internal pipes 22 may be less than 180 ° or greater than 180 °. The pipe connection 1 is used for directly communicating a mixing chamber 21 of a mixer body 2 of the mixer 100, in particular an inner pipe 22 of the mixing chamber 21, with a liquid inlet pipe 4, and both ends thereof can be respectively inserted into the inner pipe 22 and the liquid inlet pipe 4, so that a small-section fluid passage with a small size and a short length can be realized, thereby realizing stable jet flow.

As shown in fig. 1 and 2, a pipe coupling 1 according to at least one embodiment of the present invention includes a main body 11, a first section 12, a second section 13, and a fluid passage penetrating the main body 11, the first section 12, and the second section 13. The body portion 11 includes a first side 111 and a second side 112 opposite the first side 111. The first section 12 extends outwardly from a first side 111 of the body portion 11 and the second section 13 extends outwardly from a second side 112 of the body portion 11.

Illustratively, the first section 12 has a frustoconical shape with a maximum outer diameter at the first side 111, extending outwardly from the first side 111, and gradually decreasing in outer diameter. In this embodiment, the maximum outer diameter of the first section 12 is smaller than the diameter of the first side 111. The first section 12 is adapted to be connected to an internal conduit 22. Illustratively, the first section 12 is connected to the internal conduit 22 in such a way that the first section 12 is at least partially inserted into the internal conduit 22.

The second section 13 also has, for example, a truncated cone shape with a maximum outer diameter at the second side 112, extending outwardly from the second side 111 and gradually decreasing in outer diameter. In this embodiment, the second section 13 has a maximum outer diameter that is less than or equal to the diameter of the second side 112. The second section 13 is intended to be connected to the feed line 3. The second section 13 is connected to the feed line 3 in such a way that the second section 13 is at least partially inserted into the feed line 3.

The depth to which the first 12 and second 13 sections are inserted into the respective internal conduit 22 and feed conduit 3 depends on the outer diameter of the first 12 and second 13 sections. In this embodiment, the maximum outer diameter of the first section 12 may be greater than the inner diameter of the inner tube 22 and the minimum outer diameter of the first section 12 is less than the inner diameter of the inner tube 22, so that the side wall of the first section 12 will press against the inner wall of the inner tube 22, i.e. a portion of the first section 12 is inserted into the inner tube 22, as shown in fig. 5B. Similarly, the largest outer diameter of the second section 13 may be larger than the inner diameter of the connection of the feed liquor line 3 with the second section 13 and the smallest outer diameter of the second section 13 is smaller than the inner diameter of the connection of the feed liquor line 3 with the second section 13, such that a part of the second section 13 is inserted into the feed liquor line 3. The method of installing the second section 13 will be described in detail later in the description of an embodiment of the method of installing the pipe connection.

Alternatively, the maximum outer diameter of the first section 12 may be slightly smaller than the inner diameter of the inner pipe 22, while the outer diameter of the main body is larger than the inner diameter of the inner pipe 22, so that the first side 111 of the main body 11 directly abuts against the end of the inner pipe 22, and the first section 12 is fully inserted into the inner pipe 22, as shown in fig. 5A.

The inclination angle of the truncated cone shape of the first and second sections 12, 13 is in the range of 0 to 45 degrees, i.e. the included angle of the generatrix of the truncated cone with the axial direction a is in the range of 0 to 45 degrees. The above arrangement is to facilitate obtaining longer lengths of the first and second sections 12, 13. If the inclination angle is too large, the length of the first section 12 and the second section 13 is small with the same end outer diameter, resulting in a small length extending into the inner pipe 22 and the feed pipe 3, making it difficult to form a stable connection.

The term "axial direction" as used in the present disclosure refers to a direction along the axis of the rotator, and is a horizontal left direction as shown in fig. 2.

The dashed line in fig. 2 shows a fluid channel comprising a first flow channel 14 in fluid communication with the inner conduit 22 and a second flow channel 15 in fluid communication with the inlet conduit 3, whereby the first flow channel 14 is arranged in the first section 12 and the second flow channel 15 is at least partly arranged in the main body 11 and the second section 13. As shown in fig. 2, the first flow channel 14 is illustratively a circular through hole, and the second flow channel 15 is a stepped hole (it is understood that the second flow channel 15 may also be a circular through hole, and the first flow channel 14 is a stepped hole) extending to one end of the first flow channel 14.

Illustratively, the inner diameter of the first flow passage 14 is smaller than the inner diameter of the second flow passage 15. The first flow channel 14 serves as a small cross-section flow channel for generating the jet and may have an inner diameter of between 1/100 and 1, such as 1/80, 1/60, 1/30, 1/20, 1/10, 1/5 or 1/3 of the inner diameter of the second flow channel 15.

The inner diameter of the first flow passage 14 may be 1/200 to 1/2, such as 1/100, 1/80, 1/50, 1/30, 1/15, 1/10, 1/5, or 1/3 of the inner diameter of the inner conduit 22. The inner diameter of the first flow passage 14 may be 1/3 to 1/10, such as 1/4, 1/5, 1/6, 1/7, 1/8 or 1/9 of the smallest outer diameter of the first section 12.

The maximum outer diameter of the first section 12 is close to the inner diameter of the inner conduit 22 and may be slightly larger or slightly smaller or both.

The inner diameter of the second flow channel 15 may be 1/10 to 9/10, such as 1/5, 2/5, 3/5 or 4/5 of the inner diameter of the feed line 3. The inner diameter of the second flow passage 15 may be 1/3 to 19/20, such as 1/2, 2/3, 3/5, 5/6, 7/8, 9/10, 14/15 or 17/18 of the smallest outer diameter of the second section 13.

The ratio of the length of the first flow passage 14 to the inner diameter of the first flow passage 14 is between 1 and 50, such as 2, 4, 5, 8, 10, 15, 20, 25, 30, 35, 40 or 45. The length of the first flow channel 14 is less than 1/6, 1/5, 1/4, 1/3 or 1/2 of the length of the second flow channel 15.

The length of the second flow passage 15 may be the total length of the pipe connection 1 minus the length of the first flow passage 14.

Alternatively, the inner diameter of the second flow passage 15 varies in the axial direction a, for example, the inner diameter of the end of the second flow passage 15 near the first flow passage 14 is smaller than the inner diameter of the other end far from the first flow passage 14.

The second section 13 is additionally provided with a slot 16, the slot 16 extending from the end of the second section 13 remote from the body portion 11 and being rectangular in cross-section. The groove 16 serves to detach the pipe connection 1 from the inner pipe 22 of the mixing chamber 21.

In addition, the length of the first flow passage 14 also needs to be set relatively small to achieve a short distance to maintain a high velocity jet, preventing a fluid pressure drop. The first flow channel 14 extends through at least part of the first section 12 and the length of the first flow channel 14 is smaller than the length of the second flow channel 15 and the length of the first flow channel 14 is between 0.02mm and 1mm, such as 0.05mm, 0.1mm, 0.2mm, 0.3mm, 0.5mm or 0.8mm.

With respect to the second flow channel 15, it may extend through the body portion 11 and/or the second section 13 and at least partially to the first section 12.

A preformed liquid, such as an mRNA solution or a liposome solution, is passed from the inlet line into the second flow channel 15 and subsequently into the first flow channel 14. Due to the abrupt decrease in cross-section, the pre-formed liquid is pressurized and accelerated and ejected through the first flow channel 14 forming a jet.

According to the above features, by providing the pipe connection 1 abutting between the liquid inlet pipe and the internal pipe of the mixing chamber, no additional joint is required, and the length of the first flow passage 14 for pressurization and acceleration is small and close to the mixing chamber, which is advantageous in maintaining the jet high pressure and providing a stable and reliable liquid jet, improving the production efficiency and quality.

In this embodiment, a sloped transition is employed between the first flow passage 14 and the second flow passage 15, thereby preventing the formation of unstable turbulence or eddies in the variable diameter region between the two flow passages, and making the operation of the fluid smoother. Alternatively, a curved transition between the first flow channel 14 and the second flow channel 15 may be used.

Illustratively, the pipe connection 1 of the present disclosure may be made of plastic. Alternatively, the line connection 1 may be made of other plastic materials such as metals, alloys, ceramics, rubber or composite materials.

Fig. 3 exemplarily shows a cross-sectional view of the mixer body 2, and the description of the mixer body 2 facilitates understanding of the mounting relationship of the mixer 100. The mixer body 2 comprises at least one internal pipe 22, a mixing chamber 21, and fitting pipes 8 in one-to-one correspondence and communication with the internal pipe 22. In this embodiment, the mixer body 2 includes two internal pipes 22 and two corresponding fitting pipes 8, the internal pipes 22 and the fitting pipes 8 are integrally connected, both ends of the internal pipes 22 are respectively communicated with the mixing chamber 21 and the fitting pipes 8, and the other ends of the fitting pipes 8 are opened outwards. Alternatively, the mixer body 2 may be provided with a greater number of internal pipes 22 and fitting pipes 8 as required.

With continued reference to fig. 3, the fitting line 8 includes a first portion 81, a second portion 82, and a third portion 83 disposed in sequence in the axial direction. The first portion 81 communicates with the internal pipe 22, the third portion 83 opens outwardly, and both ends of the second portion 82 communicate with the first portion 81 and the third portion 83, respectively. Furthermore, the first portion 81 has a cylindrical inner surface, the second portion 82 has a frustoconical inner surface, and the third portion 83 is at least partially provided with an internal thread 84, for example, provided on the side close to the opening, to facilitate screwing in of the feed line 3.

Illustratively, the line connection 1 and the inlet line 3 may be detachably connected to the fitting line 8 by fasteners. The fastener may be a single piece or a combination of multiple fasteners.

Fig. 4 illustrates a partial cross-sectional view of a pipe connection 1 mounted to a mixer 100 according to at least one embodiment of the present disclosure, and fig. 4 illustrates an exemplary mounting of one of the pipe connections. As shown in fig. 4, the line connection 1 and the feed line 3 are detachably connected to the fitting line 8 by means of fasteners 4, 7.

Specifically, the first fastening piece 7 is hollow and sleeved outside the liquid inlet pipeline 3, and at least part of the outer surface of the first fastening piece 7 is in a truncated cone shape. The second fastening member 4 is also hollow and is sleeved outside the feed liquor pipe 3, the second fastening member 4 being provided with an external thread for threaded engagement with an internal thread 84 of the third portion 83 of the fitting pipe 8.

The first fastener 7 may be a blade ring, which may be of a cone structure, or of a cone structure at one end and a flat head structure at the other end, for example.

For example, the end of the second fastener 4 may be provided with a protrusion, which may be hexagonal in cross-section to facilitate screwing.

The most basic requirement for the connection of the feed line 3 to the mixer is that the line and the connection can be tightly connected together at the operating pressure. A further requirement is that it be easy to install and disassemble.

Fig. 4 shows a partial sectional view of the pipe connection 1 in the mixer 100 after being mounted in place. The first fastening member 7 is located between the pipe connection 1 and the second fastening member 4, i.e. the distance between the first fastening member 7 and the inner pipe 22 is smaller than the distance between the second fastening member 4 and the inner pipe 22. The second fastening member 4 is screwed with the fitting line 8, in particular with the internal thread 84 of the third portion 83 of the fitting line 8, such that a pressure seal is provided between the first fastening member 7 and the line connection 1, and the outer surface of the first fastening member 7 cooperates with the second portion 82 of the fitting line 8 and forms a fluid seal when the pressure seal is provided, and the body portion 11 of the line connection 1 cooperates with the first portion 81 of the fitting line 8 and forms a fluid seal when the pressure seal is provided.

Alternatively, the first fastener 7, the second fastener 4, the liquid feed line 3 may be made of stainless steel material or molded of high strength plastic (e.g. PEEK, PTFE), or made of PEEK (inner PEEK, outer stainless steel) clad with stainless steel.

To ensure fluid centring, the fitting line 8, the inner line 22, the feed line 3 and the fastening elements 4, 7 are arranged concentrically.

In the embodiment shown in fig. 4, the maximum outer diameter of the first section 12 is slightly smaller than the inner diameter of the inner conduit 22, so that the first section 12 extends completely into the inner conduit 22.

In other embodiments, as shown in fig. 5A, the end of the feed pipe 22 is interference fit with the pipe connector 1, where the maximum outer diameter of the first section 12 may be larger than the inner diameter of the inner pipe 22, while the minimum outer diameter of the first section 12 may be smaller than the inner diameter of the inner pipe 22, so that the side wall of the first section 12 will press against the inner wall of the inner pipe 22, and self centering is achieved by the adaptive fit of the rotator.

Fig. 6 illustrates a schematic cross-sectional view of a mixer in accordance with at least one embodiment of the present disclosure. Exemplary embodiments of the mixer proposed by the present disclosure will be described below in connection with fig. 6 and the embodiments of the pipe connection described previously.

As shown in fig. 6, the mixer 100 includes a mixer body 2, a feed pipe 3, fasteners 4,7, and a pipe connection 1 as previously described. The structure of the mixer body 2 can be described with reference to fig. 3, for example. In this embodiment, the mixer body 2 includes two internal pipes 22 and two corresponding fitting pipes 8, the internal pipes 22 and the fitting pipes 8 are integrally connected, both ends of the internal pipes 22 are respectively communicated with the mixing chamber 21 and the fitting pipes 8, and the other ends of the fitting pipes 8 are opened outwards.

Two liquid inlet pipelines 3 are correspondingly arranged on two assembly pipelines 8 of the mixer main body 2, and the two liquid inlet pipelines 3 are respectively used for different solutions to enter. For example, for applications for preparing lipid nanoparticles, one of the feed lines 3 is used to jet the mRNA solution into the mixing chamber 21 via one of the internal lines 22, and the other feed line 3 is used to jet the liposome solution into the mixing chamber 21 via the other internal line 22. The arrangement of the fasteners and the mounting lines of the mixer 100 can be seen from the description of the embodiment shown in fig. 4, and will not be described again.

For example, the length of the first section 12 may be determined according to the following formula:

Where k is equal to the distance between two internal pipes 22 of the plurality of internal pipes 22 of the mixing chamber 21 of the mixer main body 2, d is equal to the desired correlation distance, and k is greater than d.

The closer correlation distance is advantageous for improving the lipid nanoparticle preparation efficiency and quality of the mixer, and the appropriate length L of the first section can be selected accordingly according to the desired correlation distance d. The corresponding expected correlation distance d is different for different fluids due to their different physical properties. The length L of the first section of the pipeline connecting piece provided by the invention can be designed and selected according to the expected correlation distance d, so that a plurality of different fluids can be adapted, and the overall design flexibility and the practicability of the mixer are higher.

The length of the second section 13 is illustratively 1/2 to 5, such as 2/3, 1, 1.5, 2, 2.5, 3, 3.5, 4 or 4.5, of the length of the body portion 11.

In yet another aspect, the present disclosure also proposes a method of installing a pipe connection 1 as described above to a mixer body 2 of a mixer 100 as described above. The method may comprise the steps of:

s1, connecting a second section 13 of the pipeline connector 1 to the end part of the liquid inlet pipeline 3;

S2, sleeving the fastener on the liquid inlet pipeline 3, wherein the fastener can freely slide along the outer surface of the liquid inlet pipeline 3;

s3, detachably connecting the liquid inlet pipeline 3 with the pipeline connecting piece 1 and the fastening piece to the assembling pipeline 8.

Further, the step S2 may specifically include the following steps:

S21, sequentially sleeving the first fastening piece 7 and the second fastening piece 4 on the liquid inlet pipeline 3, wherein the distance between the first fastening piece 7 and the internal pipeline 22 is smaller than the distance between the second fastening piece 4 and the internal pipeline 22;

further, the step S3 may specifically include the following steps:

s31, inserting the feed liquid pipe 3 equipped with the pipe connecting member 1 and the first and second fastening members 7, 4 into the fitting pipe in the axial direction a, and screwing the second fastening member 4 with the third portion 83 of the fitting pipe 8.

In the S31 installation process, the liquid inlet pipe 3 to which the pipe connection member 1 is connected is inserted into the inner pipe 22 in the axial direction a, the pipe connection member 1 is secured against the end of the inner pipe 22, and the holding force F in the axial direction a is always applied to the liquid inlet pipe 3. The second fastening member 4 is then screwed to move in the axial direction a so that the second fastening member 4 and the first fastening member 7 approach the inner pipe 22.

When the outer surface of the first fastener 7 comes into contact with the inner surface of the second portion 82 of the fitting pipe 8, the resistance to screwing the second fastener 4 becomes large, and the second fastener 4 is appropriately screwed so as to press the first fastener 7 (or can be screwed by means of a tool). On the one hand, the extrusion can lead the outer surface of the first fastening piece 7 to be in close contact with the inner surface of the second part 82 of the assembly pipeline 8, so that leakage does not occur under the high-pressure mobile phase, and on the other hand, the tip of the first fastening piece 7 is reduced due to extrusion, so that the liquid inlet pipeline 3 can be tightly hooped, leakage is avoided, and the high-pressure of the mobile phase can be ensured not to push the liquid inlet pipeline 3 out of the second fastening piece 4 and be always clung to the pipeline connecting piece 1.

Conversely, when it is desired to detach the pipe connection 1 from the mixer 100, the second fastening member 4 is first unscrewed in the opposite direction, moved in the opposite direction to the axial direction a, and finally separated from the first fastening member 7. After the first fastener 7 is separated from the second fastener 4, the first fastener 7 is loosened to be separated from the liquid inlet pipe 3, so that the liquid inlet pipe 3 can be drawn out of the mixer 100. Three situations may occur at this time, one being that the end of the feed-in line 3 is embedded in the side wall of the second section 13 of the line connection 1 so that the two are formed in one piece, and the line connection 1 is also withdrawn at the same time as the feed-in line 3 is withdrawn. The second case is that the feed line 3 is separated from the line connection 1 and also from the end of the inner line 22, in which case the line connection 1 can be removed directly. The third case is that the pipe connection 1 is inserted into the end of the internal pipe 22, and after the liquid inlet pipe 3 is drawn out, the pipe connection 1 remains in the fitting pipe 8, and at this time, the pipe connection 1 can be rotated out by inserting a tool such as a screwdriver into the fitting pipe 8 to be engaged with the groove 16.

The traditional fluid connector directly connects the liquid inlet pipeline 3 into the internal pipeline 22, and the liquid inlet pipeline 3 is directly inserted to abut against the internal pipeline 22 by force application during installation and is tightly pressed by the blade ring. In contrast, the mixer 100 according to the present disclosure is further provided with the pipe connection 1 between the inlet pipe 3 and the internal pipe 22, so that it is necessary to ensure the fluid-tightness between the pipe connection 1 and the inlet pipe 3 in addition to the fluid-tightness between the pipe connection 1 and the internal pipe 22 during installation. Even if the pressing force F is applied during the installation, sealing problems between the pipe connection 1 and the inner pipe 22 or between the pipe connection 1 and the feed pipe 3 may occur.

For example, as shown in fig. 9, since the applied pressing force F is insufficient, the feed liquid pipe 3 is only abutted against the side wall of the pipe coupling 1 after being mounted in place, and the contact therebetween is a line contact, so that there is a leakage risk.

To this end, on the other hand, optionally, the present disclosure also proposes a method of mounting a pipe connection for mounting a pipe connection 1 as described above to a mixer body 2 of a mixer 100 as described above. This is achieved by providing the fitting connection 9 separately and adding a one-step mounting and dismounting process.

The fitting connection 9 comprises a body portion 91 and a second section 92, the body portion 91 being substantially cylindrical, the second section 92 being identical to the second section 13 of the line connection 1. The length of the body portion 91 in the axial direction a is smaller than the length of the body portion 11 of the pipe joint 1, as shown in fig. 7. In practice, the fitting connection 9 may be formed by the line connection 1 with the first section 121 and a portion of the body 11 cut away.

The second section 92 is additionally provided with a groove 94, the groove 94 extending from an end of the second section 92 remote from the body portion 91 and being formed rectangular in cross section. Furthermore, the fitting connection 9 may also comprise a through hole 93. The through-hole 93 is also not necessary, since the fitting connection 9 is only intended for pre-installation and does not actually pass the fluid.

The installation method specifically comprises the following steps:

K1, connecting the second section 13 of the fitting connection 9 to the end of the feed line 3;

K2, sleeving the fastener on the liquid inlet pipeline 3, wherein the fastener can freely slide along the outer surface of the liquid inlet pipeline 3;

k3, detachably connecting the assembly connector 9 and the liquid inlet pipeline 3 of the fastener to the assembly pipeline 8;

k4, taking out the liquid inlet pipeline 3 provided with the assembly connecting piece 9 and the fastening piece from the assembly pipeline 8;

k5, removing the assembly connector 9 from the liquid inlet pipeline 3;

k6, connecting the second section 13 of the pipe connection 1 to the end of the feed liquor pipe 3;

k7, detachably connecting the inlet pipe 3 equipped with the pipe connection 1 and the fastening members 4,7 to the fitting pipe 8.

Step K6 may further include a step such as step S21 of the foregoing embodiment, and step K7 may further include a step such as step S31 of the foregoing embodiment. Similarly, step K3 may also include the step of step S31 of the previous embodiment in analogy, except that the line connection 1 is replaced with the fitting connection 9.

Fig. 8A to 8D are schematic views illustrating an installation process of a pipe coupling according to at least one embodiment of the present disclosure, which is intended to describe a principle of the method for improving sealing performance.

For simplicity of description, fig. 8A to 8D omit the pipe structure in part of the mixer body, and the end of the internal pipe 22 is denoted by the plane S. It should be noted that in order to ensure a seal in the axial direction a, the installation process may always apply a pressing force F to the feed line 3 in the axial direction a.

The following description will be given by taking only an example in which the fasteners include the first fastener 7 and the second fastener 4.

First, fig. 8A exemplarily shows that without the pipe connection 1, the feed liquid pipe 3 is directly inserted into the fitting pipe 8, and the feed liquid pipe 3 is directly force-inserted into and against the inner pipe 22 when installed, and the second fastening member 4 is tightened such that the first fastening member 7 (e.g., blade ring) presses the feed liquid pipe 3. Since the outer diameter of the feed line 3 is given, the position of the first fastening member 7 in the axial direction a is also determined when the first fastening member 7 is compressed by contracting the inner diameter, and the left side of the first fastening member 7 is at a distance L ₀ from the plane S.

In the installation method of the present embodiment, the pipe joint 1 is not directly installed first, but the fitting joint 9 is installed first. After tightening the second fastener 4 and installing it in place, the first fastener 7 is still pressed against the feed liquor pipe 3, so that the left side of the first fastener 7 is still at a distance L ₀ from the plane S, while the left side of the feed liquor pipe 3 is at a distance L ₁ from the left side of the first fastener 7 that is smaller than L ₀, due to the presence of the fitting connection 9 between the feed liquor pipe 3 and the plane S, as shown in fig. 8B. Further, tightening the second fastening member 4 applies a large force such that the first fastening member 7 is pressed or even partially pressed into the outer surface of the feed-in pipe 3, i.e. the first fastening member 7 presses or even deforms the outer surface of the feed-in pipe 3, whereby the two are formed as an inseparable whole.

Thus, after screwing the second fastening member 4 in the opposite direction to the axial direction a and removing the fitting connection 9 from the inner tube 22, the first fastening member 7 and the feed-in tube 3 remain as an inseparable whole, and the left side of the feed-in tube 3 is still located at a distance L ₁ from the left side of the first fastening member 7.

At this time, the pipe joint 1 is mounted. Fig. 8C shows a state in which the pipe coupling 1 is inserted into the internal pipe 22 and one side of the main body 11 contacts the plane S. It can be seen from fig. 8C that the inlet line 3 now has contacted the outer surface of the second section 13 of the line connection 1, but the first fastener 7 has not contacted the second portion of the fitting line 8. Next, the tightening of the second fastening member 4 is continued, which pushes the first fastening member 7 and the feed liquid conduit 3 to continue to move in the axial direction a. Since the pipe connection 1 is made of plastic (or other plastic material such as metal, alloy, ceramic, rubber or composite material) with a certain plastic deformation space, the second section 13 of the pipe connection 1 is compressed and extruded into the feed liquid pipe 3.

The second fastener 4 is then continued to be tightened until it is in place, as shown in fig. 8D, at which point the left side of the first fastener 7 is at a distance L ₀ from the plane S, and the left side of the feed line 3 is at a distance L ₁ from the left side of the first fastener 7. Since the length of the main body 11 of the pipe connector 1 in the axial direction a is greater than the length of the main body 91 of the fitting connector 9, the pipe connector 1 having a larger size can be realized only by compressing and extruding the second section 13 into the liquid inlet pipe 3, the length of the compressed main body 11, or the main body 11 pressed into the plane S or a combination of the above three effects on the premise of corresponding to the size space L ₀-L₁ of the fitting connector 9. In either case, the sealing properties of the tubing, such as the sealing properties between the inner tubing 22 and the tubing connector 1, or the sealing properties between the tubing connector 1 and the feed line 3, are improved.

Illustratively, the length of the body portion 11 may be equal to or less than L ₀ and equal to or greater than the difference in length between the body portion 11 of the line connection 1 and the body portion 91 of the fitting connection 9, and the greater of 1/5 of the first portion 81 of the fitting line 8. For example, when the difference in length between the main body portion 11 of the pipe coupling 1 and the main body portion 91 of the fitting coupling 9 is greater than 1/5 of the first portion 81 of the fitting pipe 8, the length of the main body portion 11 may be greater than or equal to the difference in length between the main body portion 11 of the pipe coupling 1 and the main body portion 91 of the fitting coupling 9, and vice versa.

The pipe coupling and the method of installing the same, and the exemplary embodiment of the mixer including the same, as set forth in the present disclosure, have been described in detail hereinabove with reference to the preferred embodiments, however, it will be understood by those skilled in the art that various changes and modifications may be made to the specific embodiments described above without departing from the concept of the present disclosure. In addition, various technical features, structures set forth in various aspects of the disclosure may be variously combined without departing from the scope of the disclosure, which is defined by the appended claims.

Claims (21)

1. A pipe connection for a mixer, the mixer comprising a mixer body for mixing fluids flowing into different internal pipes by different feed pipes through their respective corresponding pipe connections, the pipe connection comprising:

a main body portion including a first side configured to face an internal pipe of a mixing chamber of the mixer main body and a second side opposite to the first side, the second side configured to face an end of a liquid inlet pipe;

a first section extending from a first side of the body portion for connection with the internal conduit;

a second section extending from a second side of the body portion for connection with the feed line, and

A fluid passage extending through the body portion, the first section, and the second section, the fluid passage including a first flow passage and a second flow passage in fluid communication, the first flow passage configured to be in fluid communication with the internal conduit, the second flow passage configured to be in fluid communication with the liquid inlet conduit;

wherein the inner diameter of the first flow channel is smaller than the inner diameter of the second flow channel.

2. The pipe connection of claim 1, wherein the length L of the first section is determined according to the following equation:

Wherein k is equal to a distance between two of the plurality of internal conduits of the mixing chamber of the mixer body, d is equal to a desired correlation distance, and wherein k is greater than d.

3. The pipe coupling according to claim 1, wherein said body portion, said first section and said second section have a solid of revolution shape, and wherein an axial direction of a solid of revolution is parallel to an axial direction of said body portion, said first flow passage and said second flow passage, and wherein a center of revolution of a solid of revolution is concentric with said body portion, said first flow passage and said second flow passage.

4. The line coupling according to claim 3, wherein the first section has the shape of a truncated cone with a maximum outer diameter on the first side, the first section having a maximum outer diameter which is smaller than or equal to the diameter of the first side, and wherein the truncated cone has an inclination angle in the range of 0 to 45 degrees, and wherein the first section is connected to the inner line in such a way that the first section is at least partially inserted into the inner line, and/or,

The second section has a truncated cone shape with a maximum outer diameter at the second side, the second section maximum outer diameter being smaller than or equal to the diameter of the second side, and wherein the truncated cone has an inclination angle in the range of 0 to 45 degrees, and wherein the second section is connected to the liquid inlet line in such a way that the second section is at least partially inserted into the liquid inlet line.

5. The pipe coupling according to claim 4, wherein said first segment has a maximum outer diameter greater than an inner diameter of said inner pipe and a minimum outer diameter less than an inner diameter of said inner pipe, and/or,

The maximum outer diameter of the second section is larger than the inner diameter of the joint of the liquid inlet pipeline and the second section, and the minimum outer diameter of the second section is smaller than the inner diameter of the joint of the liquid inlet pipeline and the second section.

6. The pipe connection of any one of claims 1 to 5, wherein the first flow passage extends through at least part of the first section, and wherein the second flow passage extends through the body portion and/or the second section and at least part of the first section.

7. The pipe connection of any one of claims 1 to 5, wherein the ratio of the inner diameters of the first and second flow passages is in the range of 1/30 to 1.

8. The pipe coupling according to any one of claims 1 to 5, wherein the length of said first flow passage is less than 1/6, 1/5, 1/4, 1/3 or 1/2 of the length of said second flow passage.

9. The pipe coupling according to claim 1, wherein said first and second flow passages are sloped or curved.

10. The pipe coupling according to claim 1, wherein said second flow passage has an inner diameter that varies in an axial direction and said second flow passage has a smaller inner diameter proximate a first end of said first flow passage than a second end distal said first flow passage.

11. The pipe connection of claim 1, wherein a side of the second section remote from the second side is further provided with a slot extending from an end of the second section remote from the main body portion for removing the pipe connection from the internal pipe.

12. A mixer, comprising:

A mixer body comprising:

At least one internal conduit;

A mixing chamber, the internal pipe opening into the mixing chamber, the mixing chamber being used for mixing the fluid entering the mixing chamber from the internal pipe, and

The assembly pipelines are in one-to-one correspondence and communicated with the at least one internal pipeline;

At least one liquid inlet pipeline corresponding to the at least one internal pipeline one by one and used for introducing fluid from outside;

The line connection of any one of claims 1 to 11, wherein the first side of the line connection faces the internal line and the second side faces an end of the at least one feed line, and

A fastener is configured to removably connect the line connection and the at least one feed line to the fitting line.

13. The mixer of claim 12, wherein the mounting tube includes a first portion, a second portion, and a third portion disposed in sequence along an axial direction, the first portion having a cylindrical inner surface, the second portion having a frustoconical inner surface, the third portion being at least partially provided with internal threads, the first portion being in fluid communication with the inner tube, and

Wherein the fastener comprises:

a hollow first fastener sleeved outside the liquid inlet pipeline, at least part of the outer surface of the first fastener is a truncated cone, and

A hollow second fastening piece sleeved outside the liquid inlet pipeline and provided with external threads,

Wherein the distance between the first fastener and the internal pipe is smaller than the distance between the second fastener and the internal pipe, and

The second fastening piece is in threaded connection with the assembly pipeline, so that the first fastening piece and the pipeline connecting piece are tightly pressed and sealed.

14. The mixer of claim 12, wherein the fitting line, the internal line, the feed line, and the fastener are disposed concentrically.

15. The mixer of claim 12, wherein the mixer is a jet mixer.

16. The mixer of claim 12, wherein an end of the at least one feed line is an interference fit with the line connection.

17. A method of installing a pipe connection for installing a pipe connection according to any one of claims 1 to 11 to a mixer body of a mixer according to any one of claims 12 to 16, the method comprising:

Connecting a second section of the tubing connector to an end of a feed-liquid tubing;

sleeving the fastener on the liquid inlet pipeline, and

And detachably connecting a liquid inlet pipeline provided with the pipeline connecting piece and the fastening piece to the assembling pipeline.

18. The method of claim 17, wherein the fitting line comprises a first portion, a second portion, and a third portion disposed sequentially in an axial direction, the first portion having a cylindrical inner surface, the second portion having a frustoconical inner surface, the third portion being at least partially provided with internal threads, the first portion being in fluid communication with the internal line, and

The fastener comprises a hollow first fastener sleeved outside the liquid inlet pipeline, at least part of the outer surface of the first fastener is in a truncated cone shape, and a hollow second fastener sleeved outside the liquid inlet pipeline, the second fastener is provided with external threads, wherein the distance between the first fastener and the inner pipeline is smaller than the distance between the second fastener and the inner pipeline, and

Wherein, will the fastener cover is located the feed liquor pipeline includes:

Sleeving the first fastener and the second fastener on the liquid inlet pipeline;

wherein detachably connecting the liquid feed pipe equipped with the pipe connection and the fastener to the fitting pipe comprises:

The liquid inlet pipeline provided with the pipeline connecting piece, the first fastening piece and the second fastening piece is inserted into the assembling pipeline along the axial direction, and the second fastening piece is in threaded connection with the third part of the assembling pipeline.

19. A method of installing a pipe connection for installing a pipe connection according to any one of claims 1 to 11 to a mixer body of a mixer according to any one of claims 12 to 16, the method comprising:

Connecting a second section of a fitting connection to an end of a liquid feed line, wherein the fitting connection comprises a main body portion and a second section extending from one side of the main body portion, and a length of the main body portion in an axial direction is smaller than a length of the main body portion of the line connection, the second section being identical to the second section of the line connection;

Sleeving the fastener on the liquid inlet pipeline;

Detachably connecting a liquid inlet pipeline provided with the assembly connecting piece and the fastening piece to the assembly pipeline;

taking out the liquid inlet pipeline provided with the assembly connecting piece and the fastening piece from the assembly pipeline;

removing the fitting connection from the feed line;

Connecting the second section of the line connection to the end of the feed line, and

And detachably connecting a liquid inlet pipeline provided with the pipeline connecting piece and the fastening piece to the assembling pipeline.

20. The method of claim 19, wherein the fitting line comprises a first portion, a second portion, and a third portion disposed sequentially in an axial direction, the first portion having a cylindrical inner surface, the second portion having a frustoconical inner surface, the third portion being at least partially provided with internal threads, the first portion being in fluid communication with the internal line, and

The fastener comprises a hollow first fastener sleeved outside the liquid inlet pipeline, at least part of the outer surface of the first fastener is in a truncated cone shape, and a hollow second fastener sleeved outside the liquid inlet pipeline, the second fastener is provided with external threads, wherein the distance between the first fastener and the inner pipeline is smaller than the distance between the second fastener and the inner pipeline, and

Wherein, will the fastener cover is located the feed liquor pipeline includes:

Sleeving the first fastener and the second fastener on the liquid inlet pipeline;

wherein detachably connecting the liquid feed line equipped with the fitting connection and the fastener to the fitting line comprises:

The liquid inlet pipeline provided with the assembly connecting piece, the first fastening piece and the second fastening piece is inserted into the assembly pipeline along the axial direction, and the second fastening piece is in threaded connection with the third part of the assembly pipeline.

21. The method of claim 20, wherein removably connecting a feed fluid line fitted with the line connection and fastener to the fitting line comprises:

The liquid inlet pipeline provided with the pipeline connecting piece, the first fastening piece and the second fastening piece is inserted into the assembling pipeline along the axial direction, and the second fastening piece is in threaded connection with the third part of the assembling pipeline.