CN118807597B - Semi-automatic liquid preparation process with jacket air isolation function - Google Patents
Semi-automatic liquid preparation process with jacket air isolation function Download PDFInfo
- Publication number
- CN118807597B CN118807597B CN202411288818.8A CN202411288818A CN118807597B CN 118807597 B CN118807597 B CN 118807597B CN 202411288818 A CN202411288818 A CN 202411288818A CN 118807597 B CN118807597 B CN 118807597B
- Authority
- CN
- China
- Prior art keywords
- pipeline
- liquid
- filter
- tank
- liquid preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 343
- 238000002360 preparation method Methods 0.000 title claims abstract description 151
- 238000002955 isolation Methods 0.000 title claims abstract description 69
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 333
- 238000004659 sterilization and disinfection Methods 0.000 claims abstract description 81
- 239000000463 material Substances 0.000 claims abstract description 50
- 238000004140 cleaning Methods 0.000 claims abstract description 49
- 230000001954 sterilising effect Effects 0.000 claims abstract description 40
- 230000007246 mechanism Effects 0.000 claims abstract description 26
- 239000003507 refrigerant Substances 0.000 claims abstract description 19
- 238000010992 reflux Methods 0.000 claims abstract description 18
- 238000011049 filling Methods 0.000 claims abstract description 15
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 239000007924 injection Substances 0.000 claims abstract description 5
- 238000002347 injection Methods 0.000 claims abstract description 5
- 238000001914 filtration Methods 0.000 claims description 106
- 238000000926 separation method Methods 0.000 claims description 65
- 238000003756 stirring Methods 0.000 claims description 59
- 239000012528 membrane Substances 0.000 claims description 34
- 239000002699 waste material Substances 0.000 claims description 32
- 238000007789 sealing Methods 0.000 claims description 28
- 239000002351 wastewater Substances 0.000 claims description 24
- 238000009826 distribution Methods 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 14
- 238000003860 storage Methods 0.000 claims description 13
- 238000004321 preservation Methods 0.000 claims description 10
- 238000004064 recycling Methods 0.000 claims description 10
- 238000012360 testing method Methods 0.000 claims description 10
- 239000002826 coolant Substances 0.000 claims description 9
- 238000010438 heat treatment Methods 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 9
- 239000010865 sewage Substances 0.000 claims description 8
- 239000012535 impurity Substances 0.000 claims description 7
- 238000005070 sampling Methods 0.000 claims description 6
- 230000008569 process Effects 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 3
- 238000011016 integrity testing Methods 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
- 238000001514 detection method Methods 0.000 abstract description 16
- 238000011109 contamination Methods 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 96
- 239000000110 cooling liquid Substances 0.000 description 46
- 238000007599 discharging Methods 0.000 description 26
- 238000009413 insulation Methods 0.000 description 22
- 238000010586 diagram Methods 0.000 description 4
- 238000009434 installation Methods 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 238000007664 blowing Methods 0.000 description 2
- 238000005265 energy consumption Methods 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 230000036512 infertility Effects 0.000 description 2
- 238000005304 joining Methods 0.000 description 2
- 238000005096 rolling process Methods 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- 235000017166 Bambusa arundinacea Nutrition 0.000 description 1
- 235000017491 Bambusa tulda Nutrition 0.000 description 1
- 241001330002 Bambuseae Species 0.000 description 1
- 235000015334 Phyllostachys viridis Nutrition 0.000 description 1
- 238000007792 addition Methods 0.000 description 1
- 239000011425 bamboo Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000012824 chemical production Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000002912 waste gas Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F35/92—Heating or cooling systems for heating the outside of the receptacle, e.g. heated jackets or burners
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/10—Maintenance of mixers
- B01F35/145—Washing or cleaning mixers not provided for in other groups in this subclass; Inhibiting build-up of material on machine parts using other means
- B01F35/146—Working under sterile conditions; Sterilizing the mixer or parts thereof
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/181—Preventing generation of dust or dirt; Sieves; Filters
- B01F35/187—Preventing generation of dust or dirt; Sieves; Filters using filters in mixers, e.g. during venting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/20—Measuring; Control or regulation
- B01F35/21—Measuring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/90—Heating or cooling systems
- B01F2035/98—Cooling
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/22—Mixing of ingredients for pharmaceutical or medical compositions
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
Abstract
本发明提供了一种具备夹套空气隔离功能的半自动化配液工艺，属于制药配液技术领域，它解决了现有配液工艺配液效率低，冷媒系统不稳定易污染等问题。本配液工艺，包括以下步骤：完整性检测；清洗消毒；夹套层灭菌注入冷媒；配液混合；冷媒回流；重复上述步骤；空气隔离机构过滤件更换。还包括CIP消毒供给管路、CIP消毒回流管路、乙二醇供给管路、乙二醇回流管路、纯压力蒸汽管路、洁净压空管路、CIP/物料压力管路、带压热排管路、带压冷排管路、配液罐、完整性检测仪、空气隔离机构、隔离罐以及与灌装机相连接的缓冲罐。本发明各管路布局合理，输入输出稳定高效，可高效进行配液制备，可进行完整性检测，冷媒系统稳定纯净，过滤件便于更换。
The present invention provides a semi-automatic liquid preparation process with jacket air isolation function, which belongs to the field of pharmaceutical liquid preparation technology. It solves the problems of low liquid preparation efficiency, unstable and easy contamination of refrigerant system in existing liquid preparation process. The liquid preparation process includes the following steps: integrity detection; cleaning and disinfection; sterilization of jacket layer and injection of refrigerant; liquid preparation and mixing; refrigerant reflux; repeating the above steps; replacement of air isolation mechanism filter. It also includes CIP disinfection supply pipeline, CIP disinfection reflux pipeline, ethylene glycol supply pipeline, ethylene glycol reflux pipeline, pure pressure steam pipeline, clean compressed air pipeline, CIP/material pressure pipeline, pressurized hot exhaust pipeline, pressurized cold exhaust pipeline, liquid preparation tank, integrity detector, air isolation mechanism, isolation tank and buffer tank connected to filling machine. The layout of each pipeline of the present invention is reasonable, the input and output are stable and efficient, liquid preparation can be carried out efficiently, integrity detection can be carried out, the refrigerant system is stable and pure, and the filter is easy to replace.
Description
Technical Field
The invention belongs to the technical field of pharmaceutical liquid preparation, and relates to a semi-automatic liquid preparation process with a jacket air isolation function.
Background
The liquid preparation and preparation are chemical production processes, and generally, a liquid preparation tank is adopted for mixing treatment, and the liquid preparation tank has the requirement of temperature control, so that the liquid preparation tank adopts a design with a jacket, and industrial steam or chilled water is supplied to the liquid preparation tank through the jacket to perform heat exchange on a cylinder body in the liquid preparation tank, thereby realizing the heating and cooling requirements of the liquid preparation tank. When the temperature rising and lowering functions of the jacket of the liquid distribution tank are switched, the chilled water filled in the jacket is required to be emptied, and according to comprehensive consideration of environmental protection requirements, cost saving and the like, the chilled water can not be directly discharged outdoors when being emptied, and most of chilled water containing ethylene glycol, propylene glycol and the like is recycled into a circulation pipe network of the refrigerating station.
The method combines the main flow design of the semi-automatization of the existing liquid preparation process, adds a compressed air purging process on a chilled water reflux pipeline of a liquid preparation jacket, and blows the chilled water in the liquid preparation jacket back to the chilled water reflux main pipe from top to bottom so as to realize the pipe network recovery of the chilled water.
Based on the above, we propose a semi-automatic liquid preparation process with jacket air isolation function.
Disclosure of Invention
The invention aims at solving the problems in the prior art, and provides a semi-automatic liquid preparation process with a jacket air isolation function, which aims at solving the technical problems that: how to realize reasonable layout pipeline, the input and output is stable high-efficient, can carry out the preparation of joining in marriage liquid by the high efficiency, can carry out the integrality and detect, and refrigerant system is stable pure, and the filter is convenient for change simultaneously.
The aim of the invention can be achieved by the following technical scheme:
The semi-automatic liquid preparation process with jacket air isolation function comprises a CIP disinfection supply pipeline, a CIP disinfection return pipeline, a glycol supply pipeline, a glycol return pipeline, a pure pressure steam pipeline, a clean pressure pipeline, a CIP/material pressure pipeline, a hot discharge pipeline with pressure, a cold discharge pipeline with pressure, a liquid preparation tank, an integrity detector, an air isolation mechanism, an isolation tank and a buffer tank connected with a filling machine, wherein the CIP disinfection supply pipeline is connected with the liquid preparation tank and a manual sampling valve connected with the liquid preparation tank, the liquid preparation tank is connected with the CIP disinfection return pipeline and the hot discharge pipeline with pressure, the manual sampling valve is connected with the hot discharge pipeline with pressure, the glycol supply pipeline and the glycol return pipeline are connected with a jacket layer of the liquid preparation tank, the glycol supply pipeline and the glycol return pipeline are connected, and the air isolation mechanism is connected with the glycol return pipeline, the air isolation mechanism is connected with a pressurized heat drain pipeline and a pressurized cold drain pipeline, the pure pressure steam pipeline and the clean pressure air pipeline are connected with the liquid inlet end of the jacket layer of the liquid preparation tank, the liquid preparation tank is connected with the buffer tank through a pipeline, the CIP disinfection supply pipeline is also connected on the pipeline between the liquid preparation tank and the buffer tank, the CIP disinfection supply pipeline is positioned at the discharge end of the liquid preparation tank, the pipeline between the liquid preparation tank and the buffer tank is also provided with a first filter and a second filter, the integrity detector and the isolation tank are connected with the first filter in parallel, the pipeline between the integrity detector and the first filter is connected with a third filter, the pure pressure steam pipeline is connected with the pipeline of the integrity detector and the third filter, the pure pressure steam pipeline is connected with the pressurized heat drain pipeline, the CIP disinfection return pipeline is connected between the isolation tank and the buffer tank, the pure pressure steam pipeline is connected with the ethylene glycol supply pipeline and the isolation tank, the isolation tank is connected with the pressurized cold drain pipeline, the first filter, the second filter, the third filter, the clean pressure pipeline and the liquid distribution tank are all connected with the pressurized cold drain pipeline, the CIP/material pressure pipeline is connected with the feeding end on the liquid distribution tank, and the CIP disinfection return pipeline is connected with the pressurized hot drain pipeline.
The working principle of the invention is that the first filter is subjected to steam sterilization through a pure pressure steam pipeline, then the integrity detector detects the integrity of the first filter, whether the filter element is damaged or not is judged, and if the detection result is qualified, the filter element is not damaged; if the result fails, the filter element is damaged and needs to be replaced, a clean pressure air pipeline is used for discharging water wetting the filter element to an isolation tank, a sterile system is isolated from a sewage system through the principle of isolating tank water sealing, a liquid preparation tank is cleaned and disinfected through a CIP disinfection supply pipeline, a discharging end of the liquid preparation tank is cleaned and disinfected through a CIP disinfection supply pipeline, a filter I, a filter II and a buffer tank which are connected with the follow-up pipeline are cleaned and disinfected, then the cleaning and disinfecting are carried out through a CIP/material pressure pipeline, then cleaned and disinfected waste liquid flows back through the CIP disinfection return pipeline, at the moment, the inside of a jacket layer of the liquid preparation tank is empty, raw materials are injected into the inside of the liquid preparation tank through the CIP/material pressure pipeline, meanwhile, a pure pressure steam pipeline is used for steam sterilization on the inside of the jacket layer, and a sterile treatment is carried out on the air isolation mechanism, sewage generated by steam sterilization is discharged through a hot discharge pipeline with pressure or a cold discharge pipeline, then ethylene glycol is injected into the inside of the jacket layer through a drain pipe for controlling temperature, the liquid preparation tank is stirred and mixed at the temperature, then the raw materials are mixed, the raw materials are obtained, the mixed and then filtered and the mixed materials are injected into the inside of the liquid preparation tank through the filter, and finally the filter is filled into the air filter layer, after the glycol in the jacket layer is completely filtered and separated by an air isolation mechanism, the glycol is collected in a backflow way by a glycol return pipeline, steam is injected into the jacket layer of an empty liquid preparation tank by a pure pressure steam pipeline to clean the jacket layer, waste water is injected into a waste material tank to be discharged by a pressure cold discharge pipeline and a pressure hot discharge pipeline, glycol waste liquid is discharged by the pressure cold discharge pipeline, steam waste water is discharged by the pressure hot discharge pipeline, and cleaning, sterilizing and material injection are repeatedly carried out on the liquid preparation tank.
The CIP disinfection supply pipeline, the CIP disinfection return pipeline, the ethylene glycol supply pipeline, the ethylene glycol return pipeline, the pure pressure steam pipeline, the pure pressure air pipeline, the hot discharging pipeline with pressure and the cold discharging pipeline with pressure are all inclined pipelines with the feeding end higher than the discharging end.
By adopting the structure, the inclined pipeline is convenient for guiding the internal materials through self gravity, so that the energy consumption is reduced.
The pipelines among the glycol supply pipeline, the glycol return pipeline, the liquid distribution tank and the buffer tank are all cold insulation pipelines, and the pure pressure steam pipeline is an insulation pipeline.
By adopting the structure, the cold insulation pipeline is used for carrying out cold insulation treatment on the materials in the cold insulation pipeline, and the heat insulation pipeline is used for carrying out heat insulation treatment on the materials in the cold insulation pipeline, so that the temperature requirement is ensured.
The cleaning ball I is arranged below the feeding end of the liquid preparation tank connected with the CIP disinfection reflux pipeline, one feeding end of the isolation tank is provided with a heating type filter, the clean pressure air pipeline is connected with the hot air discharge pipeline, and the pipeline connected between the clean pressure air pipeline and the hot air discharge pipeline is connected with the heating type filter in parallel.
By adopting the structure, the cleaning ball is used for discharging disinfection cleaning liquid, cleaning treatment is carried out on the liquid preparation tank, and the heating filter is used for heat preservation and filtration.
And a pipeline between the liquid distribution tank and the buffer tank is also a cold insulation pipeline, exhaust ends of the first filter and the second filter are connected with a pipeline test mirror, and the pipeline test mirror is communicated with the hot air discharge pipeline under pressure.
By adopting the structure, the first filter and the second filter are used for double filtering of product materials, after one of the first filter and the second filter is damaged, the filtering can be performed, the sterility of the product is guaranteed, the exhaust ends of the first filter and the second filter are used for exhausting, air is injected into the hot exhaust pipeline under pressure, and the pipeline test mirror is used for observing whether the first filter and the second filter are full of liquid, namely whether all exhaust is performed.
The second filter and the buffer tank are both positioned at the filling machine, and the cold insulation pipeline at the front side of the second filter and the cold insulation pipeline between the second filter and the buffer tank are both connected with the hot air discharge pipeline under pressure.
By adopting the structure, the cold insulation pipelines are connected to the hot discharge pipeline under pressure and are used for discharging waste materials.
The inside magnetic stirrer that is equipped with of liquid preparation jar is equipped with integral type sight glass and light on the liquid preparation jar, is equipped with the feed inlet on the liquid preparation jar, and compressed air pipeline, CIP disinfection supply line, pure pressure steam line and clean pressure air pipeline's pressure is 7bar, and CIP/material pressure pipeline's pressure is 4bar, and the glycol liquid temperature of glycol supply line is 2~7 ℃.
By adopting the structure, the raw materials are injected into the liquid preparation tank through the feed inlet, and the magnetic stirrer is used for stirring and mixing the raw materials.
The air isolation mechanism comprises a lifting part, a waste bin and a liquid containing cylinder part which are sequentially arranged, wherein an agitating part and a filtering separation part are fixed on the lifting part, the filtering separation part is detachably clamped in the liquid containing cylinder part, the filtering separation part and the liquid containing cylinder part are connected with a jacket layer of a liquid distribution tank, the liquid containing cylinder part is connected with a glycol return pipeline, the filtering separation part and the liquid containing cylinder part are connected with the waste bin, and the waste bin is communicated with a cold drain pipeline under pressure.
By adopting the structure, the clean pressure air pipeline injects compressed air into the jacket layer of the liquid preparation tank filled with glycol cooling liquid, the glycol cooling liquid in the mixed liquid flows into the filtering separation part, the stirring part is stirred, the filtered glycol cooling liquid enters the liquid containing cylinder part and flows back into the glycol reflux pipeline for recycling, but when the liquid level of the glycol cooling liquid in the liquid containing cylinder part reaches a certain position, impurities are placed in the filtering separation part, steam is injected into the jacket layer of the empty liquid preparation tank through the pure pressure steam pipeline to clean the jacket layer, the filtering separation part is cleaned, the steam and the glycol cooling liquid remained in the filtering separation part form mixed liquid, the glycol cooling liquid in the mixed liquid sequentially flows back into the glycol reflux pipeline through the filtering separation part and the liquid containing cylinder part, the recycling is performed until the glycol cooling liquid in the liquid containing cylinder part is completely refluxed, the steam is injected into the liquid containing cylinder part for cleaning, the waste water cleaned in the filtering separation part and the liquid containing cylinder part is injected into the waste box, the glycol is discharged through the pressure steam pipeline, the steam is discharged through the pressure steam pipeline to drive the filtering separation part and the filtering separation part to be lifted up and down, and down the filtering separation part is driven by the lifting part to be replaced, and the filtering separation part is driven to be continuously lifted and replaced.
The lifting component comprises a fixed vertical frame and a lifting seat, wherein the upper end of the fixed vertical frame is fixedly provided with a lifting hydraulic push rod, the lifting seat is fixedly provided with a plurality of rollers, the rollers are arranged on the fixed vertical frame in a rolling way, the telescopic end of the lifting hydraulic push rod is fixedly connected with the lifting seat, and the side part of the lifting seat is fixedly provided with a storage rack;
the stirring part comprises a stirring motor and a mounting frame, wherein the mounting frame is fixed at the upper end of the storage frame, the stirring motor is fixed at the upper end of the mounting frame, and an output shaft of the stirring motor penetrates through the mounting frame and is fixed with a stirring shaft.
With the structure, the telescopic end of the lifting hydraulic push rod drives the lifting seat to lift, the plurality of rollers roll on the fixed vertical frame, and the lifting seat drives the storage rack to lift;
The shelf lifts to drive the stirring part to lift, so that the output shaft of the stirring motor drives the stirring shaft to rotate to stir the glycol coolant inside.
The liquid containing barrel component comprises a bracket, a liquid containing barrel body is fixed on the bracket, an upper sealing socket is arranged at the upper end of the liquid containing barrel body, a connector and a mounting connector are arranged at the side part of the liquid containing barrel body, a cleaning ball II is arranged in the connector, the mounting connector is connected with a liquid level meter, an inner sealing socket is arranged in the middle of the lower end of the liquid containing barrel body, an avoidance through hole is arranged in the inner sealing socket, and a liquid outlet pipe communicated with the liquid containing barrel body is arranged at the lower end of the liquid containing barrel body;
The filtering separation component comprises a mounting top cylinder, a filtering membrane cylinder and a lower connecting piece, wherein the upper end of the mounting top cylinder is fixedly provided with a mounting seat, the mounting seat is fixedly arranged at the lower end of the storage rack, a rotating bearing is fixedly arranged in the middle of the upper end of the mounting seat, a stirring shaft is inserted and fixed in the inner ring of the rotating bearing, a liquid inlet pipe communicated with the side part of the mounting top cylinder is arranged on the middle of the lower end of the mounting top cylinder, an upper inserting convex ring is arranged on the periphery of the lower end of the mounting top cylinder, the upper inserting convex ring is detachably inserted and connected in an upper sealing socket, the lower pipe is arranged at the upper end of the lower connecting piece, the filtering membrane cylinder is detachably screwed between the upper pipe and the lower pipe, the lower inserting convex ring is arranged at the lower end of the lower connecting piece, the lower inserting convex ring is detachably inserted and connected in a avoiding through hole, and the lower end of the lower connecting piece is provided with a liquid discharge pipe communicated with the lower connecting piece;
The upper end of the liquid inlet pipe, the lower end of the liquid outlet pipe and the lower end of the liquid outlet pipe are respectively provided with a three-way electromagnetic valve, the other two ends of the three-way electromagnetic valve on the liquid inlet pipe are respectively connected with the jacket layer and the connector, the other two ends of the three-way electromagnetic valve on the lower end of the liquid outlet pipe are respectively connected with the connection of the glycol return pipeline and one end of the three-way electromagnetic valve on the lower end of the liquid outlet pipe is connected with one end of the three-way electromagnetic valve on the lower end of the liquid outlet pipe through a flexible hose, and the other end of the three-way electromagnetic valve on the lower end of the liquid outlet pipe is connected with a waste box through a flexible hose.
With the structure, the clean pressure air pipeline injects compressed air into the jacket layer of the liquid preparation tank filled with glycol cooling liquid, the glycol cooling liquid is pressed into the filtering membrane cylinder through the liquid inlet pipe, the stirring part stirs, the filtered glycol cooling liquid enters the liquid placement cylinder part and flows back to the glycol return pipeline for recycling, but when the liquid level of the glycol cooling liquid in the liquid placement cylinder body reaches a certain position detected by the liquid level meter, impurities are placed in the filtering membrane cylinder, steam is injected into the jacket layer of the empty liquid preparation tank through the pure pressure steam pipeline to clean the jacket layer, the steam enters the filtering membrane cylinder to clean the filtering membrane cylinder, the steam and the glycol cooling liquid reserved in the filtering membrane cylinder form mixed liquid, the glycol cooling liquid in the mixed liquid sequentially flows back to the glycol return pipeline through the filtering separation part and the liquid placement cylinder part, the glycol cooling liquid is recycled until the glycol cooling liquid in the liquid placement cylinder body is completely returned, the steam is injected into the cleaning ball II through the connector, the cleaning waste liquid in the filtering membrane cylinder and the cleaning liquid tank in the liquid placement cylinder body is injected into the waste tank through the waste liquid tank, and the waste liquid is discharged through the waste water with pressure and the waste water is discharged through the waste water with pressure; when the filtering membrane cylinder of the filtering and separating component needs to be replaced, the lifting component drives the stirring component and the filtering and separating component to lift, the filtering and separating component leaves the liquid containing cylinder body, the three-way electromagnetic valve at the lower end of the liquid discharging pipe enters and passes through the liquid containing cylinder body from the avoidance through hole, the screw connection between the filtering membrane cylinder and the upper screw pipe and the lower screw pipe is released, after the new filtering membrane cylinder is replaced, the lifting component drives the stirring component and the filtering and separating component to descend, the upper inserting convex ring is inserted into the upper sealing socket, the lower part inserts and closes the bulge loop and inserts and close inside dodging the through-hole for filtering separation part and the sealed block of putting a liquid section of thick bamboo part continue filtering process, and the three-way solenoid valve of the lower extreme of fluid-discharge tube is passing dodging the through-hole, arranges in dodging the through-hole below.
The semi-automatic liquid preparation process with the jacket air isolation function comprises the following steps of firstly, performing steam sterilization on a first filter through a pure pressure steam pipeline, then performing integrity detection on the first filter through an integrity detector, judging whether a filter element is damaged or not, if the detection result is qualified, indicating that the filter element is not damaged, and if the detection result is failed, indicating that the filter element is damaged and needs to be replaced;
Cleaning and sterilizing the liquid preparation tank through a CIP sterilizing supply pipeline, wherein the joint of the CIP sterilizing supply pipeline is positioned at the discharge end of the liquid preparation tank to clean and sterilize pipelines connected subsequently, a first filter, a second filter and a buffer tank connected with the subsequent pipelines are cleaned and sterilized, then the liquid preparation tank is cleaned and sterilized through a CIP/material pressure pipeline, then waste liquid subjected to cleaning and sterilizing flows back through a CIP sterilizing return pipeline, at the moment, the inside of a jacket layer of the liquid preparation tank is empty, and then raw materials are injected into the liquid preparation tank through the CIP/material pressure pipeline;
step three, the jacket layer is sterilized and injected with a refrigerant, namely, the inside of the jacket layer is subjected to steam sterilization through a pure pressure steam pipeline, and an air isolation mechanism is sterilized, sewage generated by the steam sterilization is discharged through a hot discharge pipeline with pressure or a cold discharge pipeline with pressure, and then ethylene glycol is injected into the inside of the jacket layer through an ethylene glycol supply pipeline for controlling the temperature of a liquid preparation tank;
Step four, liquid preparation and mixing, namely stirring and mixing raw materials by a liquid preparation tank at the temperature controlled in the step three to obtain a mixed material, filtering the mixed material by a first filter, filtering the mixed material by a second filter, storing the mixed material in a buffer tank, and finally injecting the mixed material into a filling machine;
Injecting compressed air into a jacket layer of a liquid preparation tank filled with glycol cooling liquid through a clean pressure air pipeline, stirring the glycol cooling liquid by a stirring part after the glycol cooling liquid is hydraulically pressed into a filtering separation part, enabling the filtered glycol cooling liquid to enter a liquid containing cylinder part and then flow back into a glycol backflow pipeline for recycling, however, when the liquid level of the glycol cooling liquid in the liquid containing cylinder part reaches a certain position, placing impurities in the filtering separation part, injecting steam into the jacket layer of an empty liquid preparation tank through a pure pressure steam pipeline for cleaning the jacket layer, cleaning the jacket layer through the filtering separation part, enabling the steam and the glycol cooling liquid remained in the filtering separation part to form mixed liquid, enabling the glycol cooling liquid in the mixed liquid to sequentially flow back into the glycol backflow pipeline through the filtering separation part and the liquid containing cylinder part, recycling until the glycol cooling liquid in the liquid containing cylinder part is completely reflowed, injecting steam into the liquid containing cylinder part for cleaning, injecting waste water cleaned in the filtering separation part and the liquid containing cylinder part into a waste gas tank, discharging the glycol through a cold drain pipe with pressure, and discharging the steam through a hot drain pipe with pressure;
Step six, repeating the step one to the step five, and sequentially performing integrity detection, cleaning and disinfection, sterilization, material injection, liquid preparation and material conveying treatment;
And seventhly, replacing the filter element of the air isolation mechanism, namely when the part of the filter separation component needs to be replaced, driving the stirring component and the filter separation component to lift by the lifting component, and after replacement, driving the stirring component and the filter separation component to descend by the lifting component, and continuing the filtering treatment by sealing and clamping the filter separation component and the liquid containing cylinder component.
Compared with the prior art, the semi-automatic liquid preparation process with the jacket air isolation function has the following advantages:
The CIP disinfection supply pipeline, the CIP disinfection return pipeline, the pure pressure steam pipeline, the clean pressure air pipeline, the CIP/material pressure pipeline, the hot discharging pipeline under pressure, the cold discharging pipeline under pressure, the liquid preparation tank and the buffer tank connected with the filling machine are matched, the layout of each pipeline is reasonable, liquid preparation can be carried out efficiently, and the input and the output are stable and efficient;
The integrity detector, the isolation tank and the filter III are matched to realize the integrity detection of the first filter and ensure that the finished product is sterile and qualified;
The air isolation mechanism is matched with the jacket layer of the liquid preparation tank and is matched with the ethylene glycol supply pipeline and the ethylene glycol return pipeline, so that the optimized refrigerant back blowing scheme greatly reduces the influence of compressed air on a closed refrigerant circulation pipe network, improves the stability of a refrigerant system, can effectively filter the refrigerant and ensures the purity of the refrigerant;
the filter element of the air isolation mechanism is convenient to replace, the replacement time of the filter element is reduced, and better filtering treatment is met.
Drawings
FIG. 1 is a schematic diagram of a liquid distribution system according to the present invention.
FIG. 2 is a left half block diagram of the liquid dispensing system of the present invention.
FIG. 3 is a right half of the liquid distribution system of the present invention.
Fig. 4 is a schematic diagram of main connection of the liquid preparation tank in the invention.
Fig. 5 is a schematic illustration of the primary connection of the jacket air insulation of the dosing tank of the present invention.
Fig. 6 is a schematic perspective view of an air isolation mechanism according to the present invention.
Fig. 7 is a schematic view of the structure of the lifting member in the present invention.
FIG. 8 is a schematic view of the structure of the cartridge assembly of the present invention.
FIG. 9 is a schematic upper side structure of the filtering separation part in the present invention.
FIG. 10 is a schematic view showing the structure of the underside of the filtering separation member in the present invention.
Fig. 11 is a schematic view of the structure of the agitating member in the present invention.
Fig. 12 is a process flow diagram of the present invention.
In the figure, 1, lifting part, 2, stirring part, 3, three-way electromagnetic valve, 4, filtering and separating part, 5, liquid placing cylinder part, 6, waste box, 7, lifting hydraulic push rod, 8, idler wheel, 9, lifting seat, 10, storage rack, 11, fixing vertical rack, 12, bracket, 13, liquid outlet pipe, 14, internal sealing socket, 15, avoiding through hole, 16, connector, 17, upper sealing socket, 18, liquid placing cylinder body, 19, liquid level meter, 20, installation connector, 21, rotating bearing, 22, installation seat, 23, upper inserting convex ring, 24, filtering membrane cylinder, 25, lower connecting piece, 26, liquid discharging pipe, 27, installation top cylinder, 28, liquid inlet pipe, 29, upper spiral pipe, 30, lower spiral pipe, 31, lower inserting convex ring, 32, stirring motor, 33, installation rack, 34 and stirring shaft.
Detailed Description
The following are specific embodiments of the present invention and the technical solutions of the present invention will be further described with reference to the accompanying drawings, but the present invention is not limited to these embodiments.
As shown in figures 1-11, the semi-automatic liquid preparation process with jacket air isolation function comprises a CIP disinfection supply pipeline, a CIP disinfection return pipeline, a glycol supply pipeline, a glycol return pipeline, a pure pressure steam pipeline, a clean pressure air pipeline, a CIP/material pressure pipeline, a hot discharge pipeline with pressure, a cold discharge pipeline with pressure, a liquid preparation tank, an integrity detector, an air isolation mechanism, an isolation tank and a buffer tank connected with a filling machine, wherein the CIP disinfection supply pipeline is connected with the liquid preparation tank and a manual sampling valve connected with the liquid preparation tank, the liquid preparation tank is connected with the CIP disinfection return pipeline and the hot discharge pipeline with pressure, the manual sampling valve is connected with the hot discharge pipeline with pressure, the glycol supply pipeline and the glycol return pipeline are connected with a jacket layer of the liquid preparation tank, the glycol supply pipeline and the glycol return pipeline are connected, the air isolation mechanism is connected with the hot air discharge pipeline with pressure and the cold air discharge pipeline with pressure, the pure pressure steam pipeline and the clean pressure air pipeline are connected with the liquid inlet end of the jacket layer of the liquid preparation tank, the liquid preparation tank is connected with the buffer tank through a pipeline, the CIP disinfection supply pipeline is also connected on the pipeline between the liquid preparation tank and the buffer tank, the CIP disinfection supply pipeline connection part is positioned at the discharge end of the liquid preparation tank, the pipeline between the liquid preparation tank and the buffer tank is also provided with a first filter and a second filter, the integrity detector and the isolation tank are connected with the first filter in parallel, the pipeline between the integrity detector and the first filter is connected with the third filter, the pure pressure steam pipeline is connected on the pipeline of the integrity detector and the third filter, and the pure pressure steam pipeline is connected with the hot air discharge pipeline with pressure, CIP disinfection return line connects between insulation tank and buffer tank, and pure pressure steam line is connected with ethylene glycol supply line and insulation tank, and the insulation tank is connected with cold discharge pipeline under pressure, and filter one, filter two, filter three, clean air pipeline and join in marriage the fluid reservoir and all be connected with cold discharge pipeline under pressure, CIP/material pressure line connect the feed end on joining in marriage the fluid reservoir, CIP disinfection return line is connected with hot discharge pipeline under pressure.
The method comprises the steps of performing steam sterilization on a first filter through a pure pressure steam pipeline, performing integrity detection on the first filter through an integrity detector, judging whether the filter core is damaged, if the detection result is qualified, indicating that the filter core is not damaged, if the detection result is failed, indicating that the filter core is damaged and needs to be replaced, discharging water wetting the filter core to an isolation tank through a clean pressure air pipeline, isolating a sterile system from a sewage system through the principle of isolating tank water seal, performing cleaning and sterilization on a liquid distribution tank through a CIP (cleaning and sterilizing supply) pipeline, performing cleaning and sterilization on a pipeline connected with the CIP disinfection supply pipeline, performing cleaning and sterilization on a second filter and a buffer tank connected with the pipeline through a first filter and a second filter, performing cleaning and sterilization on the buffer tank connected with the subsequent pipeline, then performing cleaning and sterilization on waste liquid through a CIP (cleaning and sterilizing reflux) pipeline, filling raw materials into a liquid distribution tank through a CIP (cleaning and sterilizing reflux pipeline, filling jacket layer inside of the liquid distribution tank at the moment, performing steam sterilization on the interior of the jacket layer through the CIP/material pressure pipeline, performing steam isolation mechanism, performing cleaning and sterilizing on the sewage generated by the steam sterilization through the CIP (cleaning and sterilizing supply pipeline) through a hot water discharge pipeline or a glycol discharge pipeline, performing mixing and glycol discharge pipeline, performing cleaning and glycol control and filling into a filter jacket layer, mixing the filter layer, and a mixing layer, the method comprises the steps of collecting glycol through a glycol return pipeline in a backflow way, injecting steam into the jacket layer of an empty liquid preparation tank through a pure pressure steam pipeline to clean the glycol, injecting cleaned waste water into a waste tank, discharging glycol waste liquid through a pressurized cold discharge pipeline, discharging steam waste water through a pressurized hot discharge pipeline, and repeatedly cleaning, sterilizing and injecting materials into the liquid preparation tank.
The CIP disinfection supply pipeline, the CIP disinfection return pipeline, the ethylene glycol supply pipeline, the ethylene glycol return pipeline, the pure pressure steam pipeline, the clean pressure air pipeline, the hot discharging pipeline with pressure and the cold discharging pipeline with pressure are all inclined pipelines with the feeding end higher than the discharging end. The inclined pipeline is convenient for guiding the internal materials by self gravity, so that the energy consumption is reduced.
The pipelines among the glycol supply pipeline, the glycol return pipeline, the liquid distribution tank and the buffer tank are all cold insulation pipelines, and the pure pressure steam pipeline is an insulation pipeline. The heat preservation pipeline is used for carrying out heat preservation treatment on the materials in the heat preservation pipeline, and the heat preservation pipeline is used for carrying out heat preservation treatment on the materials in the heat preservation pipeline, so that the temperature requirement is guaranteed.
The cleaning ball I is arranged below the feeding end of the liquid distribution tank connected with the CIP disinfection reflux pipeline, one feeding end of the isolation tank is provided with a heating type filter, the clean pressure air pipeline is connected with the hot air discharge pipeline, and the pipeline connected between the clean pressure air pipeline and the hot air discharge pipeline is connected with the heating type filter in parallel. The cleaning ball is used for discharging disinfection cleaning liquid, cleaning the liquid preparation tank, and the heating filter is used for heat preservation and filtration.
And a pipeline between the liquid distribution tank and the buffer tank is also a cold insulation pipeline, exhaust ends of the first filter and the second filter are both connected with a pipeline test mirror, and the pipeline test mirror is communicated with the hot air discharge pipeline under pressure. The first filter and the second filter are used for double filtering of product materials, after one of the first filter and the second filter is damaged, the filtering can be carried out, the sterility of the product is guaranteed, the exhaust ends of the first filter and the second filter are used for exhausting, gas is injected into the hot air discharge pipeline under pressure, and the pipeline test mirror is used for observing whether the first filter and the second filter are full of liquid, namely whether all exhaust is carried out.
The second filter and the buffer tank are both positioned at the filling machine, and the cold insulation pipeline at the front side of the second filter and the cold insulation pipeline between the second filter and the buffer tank are both connected with the hot air discharge pipeline under pressure. The cold insulation pipelines are all connected to the hot discharge pipeline with pressure and are used for discharging waste materials.
The inside magnetic stirrer that is equipped with of liquid preparation jar is equipped with integral type sight glass and light on the liquid preparation jar, is equipped with the feed inlet on the liquid preparation jar, and compressed air pipeline, CIP disinfection supply line, pure pressure steam line and the pressure of clean pressure air pipeline are 7bar, and CIP/material pressure pipeline's pressure is 4bar, and the glycol liquid temperature of glycol supply line is 2~7 ℃. Raw materials are injected into the liquid preparation tank through the feed inlet, and each raw material is stirred and mixed by the magnetic stirrer.
The air isolation mechanism comprises a lifting part 1, a waste bin 6 and a liquid containing cylinder part 5 which are sequentially arranged, wherein an agitating part 2 and a filtering separation part 4 are fixed on the lifting part 1, the filtering separation part 4 is detachably clamped in the liquid containing cylinder part 5, the filtering separation part 4 and the liquid containing cylinder part 5 are connected with a jacket layer of a liquid preparation tank, the liquid containing cylinder part 5 is connected with an ethylene glycol return pipeline, the filtering separation part 4 and the liquid containing cylinder part 5 are connected with the waste bin 6, and the waste bin 6 is communicated with a cold discharge pipeline under pressure. The clean pressure air pipeline injects compressed air into the jacket layer of the liquid preparation tank filled with glycol cooling liquid, after the glycol cooling liquid is pressed into the filtering separation part 4, the stirring part 2 stirs, the filtered glycol cooling liquid enters the liquid containing cylinder part 5 and flows back to the glycol reflux pipeline for recycling, but when the glycol cooling liquid level in the liquid containing cylinder part 5 reaches a certain position, impurities are placed in the filtering separation part 4 at the moment, steam is injected into the jacket layer of the empty liquid preparation tank through the pure pressure steam pipeline to clean the jacket layer, the filtering separation part 4 is cleaned through the inside of the filtering separation part, the glycol cooling liquid remained in the steam and the filtering separation part 4 forms mixed liquid, the glycol cooling liquid in the mixed liquid sequentially flows back to the glycol reflux pipeline through the filtering separation part 4 and the liquid containing cylinder part 5, recycling is performed until the glycol cooling liquid in the liquid containing cylinder part 5 is completely refluxed, steam is injected into the liquid containing cylinder part 5 to clean the inside, the waste water in the filtering separation part 4 and the liquid containing cylinder part 5, the waste water is injected into the tank 6 through the pure pressure steam pipeline to clean the waste water, the waste water is discharged through the pure pressure steam pipeline to drive the filtering separation part 4 to replace the filtering separation part, the waste water is lifted through the sealing part 2, and the sealing part is lifted up and down when the filtering separation part is replaced by the sealing part 2, and the sealing part is lifted by the sealing part is replaced, and the sealing part is replaced by the sealing part 2.
The lifting component 1 comprises a fixed vertical frame 11 and a lifting seat 9, wherein a lifting hydraulic push rod 7 is fixed at the upper end of the fixed vertical frame 11, a plurality of rollers 8 are fixed on the lifting seat 9, the rollers 8 are arranged on the fixed vertical frame 11 in a rolling mode, the telescopic end of the lifting hydraulic push rod 7 is fixedly connected with the lifting seat 9, a storage rack 10 is fixed on the side portion of the lifting seat 9, the stirring component 2 comprises a stirring motor 32 and a mounting rack 33, the mounting rack 33 is fixed at the upper end of the storage rack 10, the stirring motor 32 is fixed at the upper end of the mounting rack 33, an output shaft of the stirring motor 32 penetrates through the mounting rack 33, and a stirring shaft 34 is fixed on the output shaft of the stirring motor 32. The telescopic end of the lifting hydraulic push rod 7 drives the lifting seat 9 to lift, the plurality of rollers 8 roll on the fixed vertical frame 11, the lifting seat 9 drives the storage rack 10 to lift, the storage rack 10 lifts and drives the stirring part 2 to lift, and accordingly the output shaft of the stirring motor 32 drives the stirring shaft 34 to rotate to stir the glycol coolant inside.
The liquid containing barrel part 5 comprises a bracket 12, a liquid containing barrel body 18 is fixed on the bracket 12, an upper sealing socket 17 is arranged at the upper end of the liquid containing barrel body 18, a connector 16 and a mounting connector 20 are arranged at the side part of the liquid containing barrel body 18, a cleaning ball II is arranged in the connector 16, the mounting connector 20 is connected with a liquid level meter 19, an inner sealing socket 14 is arranged in the middle of the lower end of the liquid containing barrel body 18, an avoidance through hole 15 is arranged in the inner sealing socket 14, and a liquid outlet pipe 13 communicated with the liquid containing barrel body 18 is arranged at the lower end of the liquid containing barrel body 18; the filtering separation part 4 comprises a mounting top cylinder 27, a filtering membrane cylinder 24 and a lower connecting piece 25, wherein the upper end of the mounting top cylinder 27 is fixedly provided with a mounting seat 22, the mounting seat 22 is fixedly arranged at the lower end of the storage rack 10, the middle part of the upper end of the mounting seat 22 is fixedly provided with a rotary bearing 21, a stirring shaft 34 is inserted and fixed in the inner ring of the rotary bearing 21, the side part of the mounting top cylinder 27 is provided with a liquid inlet pipe 28 communicated with the liquid inlet pipe, the middle part of the lower end of the mounting top cylinder 27 is provided with an upper screwed pipe 29, the periphery of the lower end of the mounting top cylinder 27 is provided with an upper inserting convex ring 23, the upper inserting convex ring 23 is detachably inserted and connected in the upper sealing socket 17, the upper end of the lower connecting piece 25 is provided with a lower screwed pipe 30, the filtering membrane cylinder 24 is detachably screwed between the upper screwed pipe 29 and the lower screwed pipe 30, the lower end of the lower connecting piece 25 is provided with a lower inserting convex ring 31, the lower inserting convex ring 31 is detachably inserted and connected in the avoidance through hole 15, the lower end of the lower connecting piece 25 is provided with a liquid outlet pipe 26 communicated with the liquid inlet pipe 28, the upper end of the liquid inlet pipe 28, the lower end of the liquid outlet pipe 13 and the lower end of the liquid outlet pipe 26 are respectively connected with the three-way electromagnetic valve 16 and the two ends of the electromagnetic valve 3 are respectively connected with the upper end of the three-way valve 16, the other two ends of the three-way electromagnetic valve 3 at the lower end of the liquid outlet pipe 13 are respectively connected with the glycol return pipeline, one end of the three-way electromagnetic valve 3 at the lower end of the liquid outlet pipe 26 is connected with the other end of the three-way electromagnetic valve 3 at the lower end of the liquid outlet pipe 26 through a flexible hose, and the other end of the three-way electromagnetic valve 3 at the lower end of the liquid outlet pipe 26 is connected with the waste bin 6 through a flexible hose.
The clean pressure air pipeline injects compressed air into the jacket layer of the liquid preparation tank filled with glycol cooling liquid, the glycol cooling liquid is pressed into the filtering membrane cylinder 24 through the liquid inlet pipe 28, then the stirring part 2 stirs, the glycol cooling liquid can pass through the filtering membrane cylinder 24 and enter the liquid preparation cylinder body 18, and can flow back to the glycol backflow pipeline through the liquid outlet pipe 13 for recycling, but when the liquid level meter 19 detects that the glycol cooling liquid level in the liquid preparation cylinder body 18 reaches a certain position, impurities are placed in the filtering membrane cylinder 24 at the moment, steam is injected into the jacket layer of the empty liquid preparation tank through the pure pressure steam pipeline to clean the jacket layer, the steam enters the filtering membrane cylinder 24 again to clean the jacket layer, the steam and the glycol cooling liquid remained in the filtering membrane cylinder 24 form mixed liquid, the glycol cooling liquid enters the liquid preparation cylinder body 18 through the filtering membrane cylinder 24 and flows back to the glycol backflow pipeline, the glycol cooling liquid is recycled until the glycol cooling liquid in the liquid preparation cylinder body 18 completely flows back, the steam is injected into the cleaning ball through the connector 16, the cleaning ball two opposite liquid cylinder body 18 is cleaned, the waste water is discharged through the waste water discharge pipe 6, and the waste water is discharged through the waste water discharge pipe 6; when the filtering membrane cylinder 24 of the filtering and separating component 4 needs to be replaced, the lifting component 1 drives the stirring component 2 and the filtering and separating component 4 to lift, the filtering and separating component 4 leaves the liquid placing cylinder body 18, the three-way electromagnetic valve 3 at the lower end of the liquid discharging pipe 26 enters from the avoiding through hole 15 and passes through the liquid placing cylinder body 18, the screw joint between the filtering membrane cylinder 24 and the upper screw 29 and the lower screw 30 is released, after the new filtering membrane cylinder 24 is replaced, the lifting part 1 drives the stirring part 2 and the filtering separation part 4 to descend, the upper inserting convex ring 23 is inserted into the upper sealing socket 17, the lower inserting convex ring 31 is inserted into the avoidance through hole 15, so that the filtering separation part 4 and the liquid placing cylinder part 5 are in sealing clamping to continue filtering treatment, and the three-way electromagnetic valve 3 at the lower end of the liquid discharge pipe 26 penetrates through the avoidance through hole 15 and is arranged below the avoidance through hole 15.
As shown in fig. 12, the semi-automatic liquid preparation process with the jacket air isolation function comprises the following steps:
the method comprises the steps of firstly, performing steam sterilization on a first filter through a pure pressure steam pipeline, then performing integrity detection on the first filter through an integrity detector, judging whether a filter element is damaged or not, if the detection result is qualified, indicating that the filter element is not damaged, and if the detection result is failed, indicating that the filter element is damaged and needs to be replaced;
Cleaning and sterilizing the liquid preparation tank through a CIP sterilizing supply pipeline, wherein the joint of the CIP sterilizing supply pipeline is positioned at the discharge end of the liquid preparation tank to clean and sterilize pipelines connected subsequently, a first filter, a second filter and a buffer tank connected with the subsequent pipelines are cleaned and sterilized, then the liquid preparation tank is cleaned and sterilized through a CIP/material pressure pipeline, then waste liquid subjected to cleaning and sterilizing flows back through a CIP sterilizing return pipeline, at the moment, the inside of a jacket layer of the liquid preparation tank is empty, and then raw materials are injected into the liquid preparation tank through the CIP/material pressure pipeline;
step three, the jacket layer is sterilized and injected with a refrigerant, namely, the inside of the jacket layer is subjected to steam sterilization through a pure pressure steam pipeline, and an air isolation mechanism is sterilized, sewage generated by the steam sterilization is discharged through a hot discharge pipeline with pressure or a cold discharge pipeline with pressure, and then ethylene glycol is injected into the inside of the jacket layer through an ethylene glycol supply pipeline for controlling the temperature of a liquid preparation tank;
Step four, liquid preparation and mixing, namely stirring and mixing raw materials by a liquid preparation tank at the temperature controlled in the step three to obtain a mixed material, filtering the mixed material by a first filter, filtering the mixed material by a second filter, storing the mixed material in a buffer tank, and finally injecting the mixed material into a filling machine;
Injecting compressed air into a jacket layer of a liquid preparation tank filled with glycol cooling liquid through a clean pressure air pipeline, pressing the glycol cooling liquid into a filtering membrane cylinder 24 through a liquid inlet pipe 28, stirring by a stirring component 2, enabling the glycol cooling liquid to pass through the filtering membrane cylinder 24 and enter the interior of a liquid preparation cylinder body 18, and enabling the glycol cooling liquid to flow back to a glycol return pipeline through a liquid outlet pipe 13 for repeated recycling, wherein when the liquid level of the glycol cooling liquid in the liquid preparation cylinder body 18 reaches a certain position, impurities are placed in the interior of the filtering membrane cylinder 24, steam is injected into the jacket layer of the empty liquid preparation tank through a pure pressure steam pipeline to clean the jacket layer, the steam enters the interior of the filtering membrane cylinder 24 again, the steam and the glycol cooling liquid reserved in the filtering membrane cylinder 24 form a mixed liquid, the glycol cooling liquid flows back into the interior of the liquid preparation cylinder body 18 through the filtering membrane cylinder 24, and is recycled until the glycol cooling liquid in the liquid preparation cylinder body 18 completely flows back, then the steam is injected into a cleaning ball through a connector 16, the interior of the liquid preparation cylinder body 18 is cleaned, the waste liquid is discharged through the waste water discharge pipe 6, and the waste water is discharged through the waste water discharge pipe and the waste water is discharged through the pressure air tank;
Step six, repeating the step one to the step five, and sequentially performing integrity detection, cleaning and disinfection, sterilization, material injection, liquid preparation and material conveying treatment;
In the seventh step, when the filtering membrane cylinder 24 of the filtering separation part 4 needs to be replaced, the lifting part 1 drives the stirring part 2 and the filtering separation part 4 to lift, the filtering separation part 4 leaves the liquid containing cylinder body 18, the three-way electromagnetic valve 3 at the lower end of the liquid discharging pipe 26 enters from the avoidance through hole 15 and passes through the liquid containing cylinder body 18, the screw connection between the filtering membrane cylinder 24 and the upper screw 29 and the lower screw 30 is released, after the new filtering membrane cylinder 24 is replaced, the lifting part 1 drives the stirring part 2 and the filtering separation part 4 to descend, the upper inserting convex ring 23 is inserted into the upper sealing socket 17, the lower inserting convex ring 31 is inserted into the avoidance through hole 15, so that the filtering separation part 4 and the liquid containing cylinder part 5 continue to carry out filtering treatment in a sealing and clamping mode, and the three-way electromagnetic valve 3 at the lower end of the liquid discharging pipe 26 passes through the avoidance through hole 15 and is arranged below the avoidance through hole 15.
In summary, through CIP disinfection supply pipeline, CIP disinfection return line, pure pressure steam pipeline, clean pressure air pipeline, CIP/material pressure pipeline, hot discharging pipeline under pressure, cold discharging pipeline under pressure, liquid preparation tank and buffer tank connected with the filling machine, each pipeline is reasonable in layout, liquid preparation can be carried out efficiently, and input and output are stable and efficient;
The integrity detector, the isolation tank and the filter III are matched to realize the integrity detection of the first filter and ensure that the finished product is sterile and qualified;
The air isolation mechanism is matched with the jacket layer of the liquid preparation tank and is matched with the ethylene glycol supply pipeline and the ethylene glycol return pipeline, so that the optimized refrigerant back blowing scheme greatly reduces the influence of compressed air on a closed refrigerant circulation pipe network, improves the stability of a refrigerant system, can effectively filter the refrigerant and ensures the purity of the refrigerant;
the filter element of the air isolation mechanism is convenient to replace, the replacement time of the filter element is reduced, and better filtering treatment is met.
The specific embodiments described herein are offered by way of example only to illustrate the spirit of the invention. Those skilled in the art may make various modifications or additions to the described embodiments or substitutions thereof without departing from the spirit of the invention or exceeding the scope of the invention as defined in the accompanying claims.
Claims (10)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411288818.8A CN118807597B (en) | 2024-09-14 | 2024-09-14 | Semi-automatic liquid preparation process with jacket air isolation function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202411288818.8A CN118807597B (en) | 2024-09-14 | 2024-09-14 | Semi-automatic liquid preparation process with jacket air isolation function |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN118807597A CN118807597A (en) | 2024-10-22 |
| CN118807597B true CN118807597B (en) | 2025-01-03 |
Family
ID=93078677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202411288818.8A Active CN118807597B (en) | 2024-09-14 | 2024-09-14 | Semi-automatic liquid preparation process with jacket air isolation function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN118807597B (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662306A (en) * | 2002-06-27 | 2005-08-31 | 益达科技责任有限公司 | Methanol steam reforming catalyst, steam reforming device and fuel cell system combining same |
| CN112617072A (en) * | 2020-11-26 | 2021-04-09 | 长春豪邦健康科技有限公司 | Aseptic preparation process based on aseptic liquid beverage |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB676468A (en) * | 1949-03-24 | 1952-07-30 | Food Processes Inc | Improvements in process for canning and sterilizing food products |
| CN205354670U (en) * | 2015-12-15 | 2016-06-29 | 中国核动力研究设计院 | 89 reactor core hangs integrated modular PWR of main pump |
| JP6252665B2 (en) * | 2016-12-08 | 2017-12-27 | 大日本印刷株式会社 | Aseptic filling apparatus and purification method thereof |
| CN110325263B (en) * | 2017-02-22 | 2022-04-19 | Emd密理博公司 | Mixed gas integrity testing of porous materials without access to the permeate side |
| CN111847542A (en) * | 2020-07-29 | 2020-10-30 | 毛昌运 | Anhydrous low-heat discharge circulating water device for wind power plant |
-
2024
- 2024-09-14 CN CN202411288818.8A patent/CN118807597B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1662306A (en) * | 2002-06-27 | 2005-08-31 | 益达科技责任有限公司 | Methanol steam reforming catalyst, steam reforming device and fuel cell system combining same |
| CN112617072A (en) * | 2020-11-26 | 2021-04-09 | 长春豪邦健康科技有限公司 | Aseptic preparation process based on aseptic liquid beverage |
Also Published As
| Publication number | Publication date |
|---|---|
| CN118807597A (en) | 2024-10-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9180422B2 (en) | Isolator | |
| CN104623751B (en) | Dialysis monitors and methods of operation | |
| CN118807597B (en) | Semi-automatic liquid preparation process with jacket air isolation function | |
| CN205740554U (en) | The clean-in-place system of recyclable cleanout fluid | |
| CN211896497U (en) | Fresh-keeping reverse osmosis water dispenser | |
| CN110935075A (en) | A hemodialysis concentrate preparation device | |
| CN201190131Y (en) | Continuous waste water treatment system with active virus | |
| CN113145585B (en) | Cleaning device of pot matching machine | |
| CN114618361A (en) | Full-automatic aseptic liquid preparation system | |
| CN101829342B (en) | Multifunctional disinfecting device | |
| CN201054964Y (en) | Casing tube type sterilization machine | |
| CN202342498U (en) | Multifunctional disinfection device | |
| CN213977605U (en) | Automatic wine brewing device | |
| CN214596553U (en) | Concentrated solution centralized preparation and supply automatic steam disinfection system for hemodialysis | |
| CN105148791B (en) | Disinfectant preparation system | |
| CN209410840U (en) | A kind of sterile liquid storage pot system | |
| CN211445718U (en) | Fermentation system | |
| CN111803693A (en) | Medical waste sterilization circulating system | |
| CN217025310U (en) | Automatic cleaning device of medicament filling equipment | |
| CN222119177U (en) | Fruit wine fermentation device and fruit wine production system | |
| CN220558307U (en) | Sterilization pipeline of tetanus ultrafiltration tank | |
| CN223602325U (en) | A multi-stage sterilization filtration device | |
| CN217436233U (en) | Special medical food inner bottle body sterilizing device | |
| CN210764500U (en) | Efficient packaged drinking water sterilization device | |
| CN223399600U (en) | Material sterile connection adding system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |