CN1183935C - Notoginseng and fermented red rice composition for preventing and treating cardiac and cerebral vascular diseases - Google Patents

Abstract

The present invention relates to a composition of notoginseng and red rice, which is used for preventing or treating cardiovascular and cerebrovascular diseases. The composition can effectively and safely prevent or treat cardiovascular and cerebrovascular diseases. In the present invention, notoginseng and red rice are used as raw materials, and are mixed with the ratio of dry notoginseng to dry red rice: 10 to 90 wt%: 90 to 10 w%; notoginseng, and the extract, the effective fractions and the effective components of the notoginseng all can be used as raw materials; red rice, and the extract, the effective fractions and the effective components of the red rice all can be used as raw materials; the composition of the notoginseng or the extract of the notoginseng, and the red rice or the extract of the red rice utilizes the obvious synergistic effects of all the components rather than simple addition to prepare the composition. The composition can be made into preparations which can be medically accepted, such as tablets, capsules (soft capsules or hard capsules), granules, medicinal powder, etc. The composition can be applied to health care food or food additives.

Description

Composition of notoginseng and red yeast rice for preventing or treating cardiovascular and cerebrovascular diseases

Field: the field of medicine and food of the present invention, which is a composition composed of notoginseng and red yeast rice for the prevention or treatment of cardiovascular and cerebrovascular diseases.

Background technology; In recent years, with the improvement of living standards and the aging of the social population, the incidence of cardiovascular and cerebrovascular diseases, such as coronary heart disease, acute cerebrovascular disease, peripheral vascular disease, etc., has a tendency to increase year by year, seriously endangering human life and health .

Cardiovascular and cerebrovascular diseases are largely caused by atherosclerosis, and atherosclerosis is a chronic disease caused by multiple risk factors. The main risk factors are: dyslipidemia, smoking, hypertension and diabetes. Therefore, it has important clinical significance for the prevention and treatment of cardiovascular and cerebrovascular diseases to start treatment from the aspects of regulating blood lipid, regulating blood pressure and regulating blood sugar.

Drugs currently on the market for the treatment of hyperlipidemia mainly include: statins, fibrates, bile acid sequestrants and niacin. The drugs most commonly used to treat hypertension are: diuretics, beta-blockers, calcium antagonists, angiotensin-converting enzyme inhibitors, and alpha-blockers. Drugs for the treatment of diabetes include: biguanides, α-glucosidase inhibitors and insulin sensitizers - thiazolidinediones, etc. Clinically, the prevention and treatment of cardiovascular and cerebrovascular diseases with these drugs has achieved certain effects, but long-term use has significant side effects, causing adverse effects on the patient's body and mind.

Therefore, according to the characteristics of long-term medication for cardiovascular and cerebrovascular diseases, it is advisable to use natural products that are effective and have less toxic and side effects.

Chinese patent application, application number: 00135783.2, titled "A Natural Composition for Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases and Its Application", and its composition also involves lovastatin, a blood lipid-lowering active ingredient produced by Panax notoginseng and fungi. However, the blood lipid-lowering effect of red yeast rice is the result of the synergistic effect of various components, and lovastatin is only one of the effective lipid-lowering ingredients in red yeast rice. This is the difference between the present invention patent and the above-mentioned invention patent.

Summary of the invention: Aiming at the shortage of current drugs for preventing and treating cardiovascular and cerebrovascular diseases, the object of the present invention is to provide a composition of notoginseng and red yeast rice for preventing or treating cardiovascular and cerebrovascular diseases, which can effectively and safely prevent or treat cardiovascular and cerebrovascular diseases disease.

The purpose of the present invention is also to conduct research on different ratios of raw materials and their extracts, effective parts or active ingredients through drug efficacy screening, and find out a drug that acts on the body through multiple ways, so as to comprehensively prevent and treat the heart and brain. The ratio relationship of the best raw materials for vascular diseases.

The object of the present invention is also to develop a series of medicines, health foods or food additives that are easy to carry and take on the basis of the above research.

The object of the present invention is achieved by the following measures:

The notoginseng and red yeast rice are used as raw materials, and the ratio of notoginseng:red yeast rice=(10%-90%):(90%-10%) is mixed according to the weight of dry matter.

The above-mentioned fungus producing red yeast rice can be Monascus anka, Monacus purpureus, Monacus albidus, Monacus barkeri, Monacus fulignosus, Monascus fulignosus Any of Monacus rubervam, Monacus rubiginosus, Monacus serorubescens and Monacus mucoroides.

The aforementioned Panax notoginseng and its extracts, effective parts and active ingredients can be used as raw materials; red yeast rice and its extracts, effective parts and active ingredients can be used as raw materials.

The composition can be a medically acceptable preparation, such as tablet, capsule (soft capsule or hard capsule), granule, powder and the like. The composition can be applied to health food or food additive.

The following introduces the efficacy of Sanqi and red yeast rice in the formula and the research on the efficacy of preventing and treating cardiovascular and cerebrovascular diseases:

(1), Panax notoginseng

Notoginseng is warm in nature, sweet and slightly bitter, enters the liver and stomach meridians, has the effect of dispelling blood stasis and relieving pain, reducing swelling and relieving pain. Extensive and in-depth research on its medicinal effects has proved that notoginseng is more effective in cardiovascular and cerebrovascular systems. Good and less toxic.

1. Lower blood pressure

Intravenous injection of Panax notoginseng saponins can reduce the aortic pressure of dogs, and the diastolic blood pressure drops more than the systolic blood pressure, and the degree of blood pressure reduction is positively correlated with the dose. Panax notoginseng saponins lower blood pressure mainly because of direct expansion of blood vessels, and may also be related to inhibition of cardiac contractility.

2. Lower blood fat

The total saponins of Panax notoginseng have an impact on the content of serum lipids, and the high-density lipoprotein (HDL-C) and HDL-C/TC values of the treatment group were significantly greater than those of the control group, but serum triglyceride (TC) and total cholesterol ( TG) content compared with the control group was not significantly different.

3. Regulate blood sugar

Panax notoginseng extract has a two-way regulating effect on blood sugar, can slightly increase the fasting blood sugar of mice, and can also have a good hypoglycemic effect on alloxan-induced hyperglycemia in mice.

Panax notoginseng saponins have a significant synergistic effect on raising blood sugar with glucagon. Notoginseng saponin Rg ₁ has obvious antagonism to the effect of raising blood sugar by glucagon, and can also reduce blood sugar in alloxan diabetic mice, and the dose-effect relationship is obvious.

4. Anti-atherosclerosis

Panax notoginseng saponins can significantly inhibit the formation _of aortic intima plaques in experimental atherosclerosis _rabbits . A ₂ (TXA ₂ ) content, thereby correcting the imbalance between PGI ₂ -TXA ₂ in model rabbits and stabilizing the intravascular environment.

(2) Red yeast rice

Red yeast rice is warm and sweet in nature, enters the liver, spleen and large intestine meridians, has the effects of promoting blood circulation and removing blood stasis, invigorating the spleen and eliminating food. It is a traditional fermented product in my country and is mainly used in food and medicine. Since 1979, the cholesterol synthesis rate-limiting enzyme 3-hydroxy-3-glutaryl coenzyme A reductase inhibitor——Monacolin-K (ie lovastatin) was extracted and isolated from red yeast rice. The study of value is increasingly extensive and in-depth.

1. Lower blood fat

Red yeast rice powder has a good preventive and therapeutic effect on hyperlipidemia, and has a good anti-atherosclerotic plaque formation effect, and the dose is positively correlated with the drug effect.

The ethanol extract of red yeast rice has the effect of reducing serum total cholesterol (TC), triglyceride (TG) and low-density lipoprotein (LDL-C) in hyperlipidemic quails, and the blood lipid-lowering activity is positively correlated with the content of lovastatin . Studies have also found that when the blood concentration of Monacolin components reaches 0.001-0.005ug/ml, cholesterol synthesis will be inhibited.

In addition, the study also found that there are other lipid-lowering active ingredients in red yeast rice, such as lecithin, etc., indicating that the blood lipid-lowering effect of red yeast rice may be the result of multi-component synergy.

2. Lower blood pressure

Red yeast rice has an effect on the systolic blood pressure of hypertension model rats, and can reduce the blood pressure of spontaneously hypertensive rats (SHR) and DOCA-salt hypertensive rats (DHR), but it has no effect on renovascular hypertensive rats (RHR). The hypotensive effect of DHR is not obvious, and the hypotensive effect on DHR is stronger than that of SHR. DHR is a low-renin type model, suggesting that red yeast rice has a better blood pressure-lowering effect on low-renin hypertensive patients.

Compared with the prior art, the present invention has the following advantages or positive effects:

1. At present, lovastatin is recognized as the lipid-lowering active ingredient in red yeast rice, and there are many and in-depth studies on this ingredient;

2. In recent years, studies have found that there are other lipid-lowering components in red yeast rice—lecithin, and components that improve the function of the cardiovascular and cerebrovascular systems—daidzein;

3. Studies have shown that the composition and mechanism of red yeast rice for reducing blood fat and preventing and treating cardiovascular and cerebrovascular diseases are complex, not only a single component works, but also act on the body through multiple channels; The function of preventing and treating cardiovascular and cerebrovascular diseases is specified in the patent claims of the present invention: red yeast rice and its extracts, effective parts and active ingredients (including lovastatin, lecithin, daidzein, etc., and the red yeast rice found in future research ingredients that have lipid-lowering activity or improve cardiovascular and cerebrovascular system functions) can be used as raw materials.

5. One of the main purposes of the patent of the present invention is to find out the combination of Sanqi or Sanqi extract with red yeast rice or red yeast rice Composition of red yeast extract, wherein the components have a significant synergistic effect rather than simple addition.

Example 1:

Mix notoginseng powder (100 mesh) and red yeast rice powder (100 mesh) in a ratio of 1:1. Experiments on regulating blood lipids, regulating blood pressure, regulating blood sugar and anti-atherosclerosis were carried out.

Example 2:

Mix notoginseng powder (100 mesh) and red yeast rice powder (100 mesh) in a ratio of 1:2. Experiments on regulating blood lipids, regulating blood pressure, regulating blood sugar and anti-atherosclerosis were carried out.

Example 3:

Mix notoginseng powder (100 mesh) and red yeast rice powder (100 mesh) in a ratio of 2:1. Experiments on regulating blood lipids, regulating blood pressure, regulating blood sugar and anti-atherosclerosis were carried out.

Example 4:

Notoginseng powder (40 mesh) was extracted three times with 95% ethanol under reflux for 2 h, 1 h, and 1 h respectively. The three filtrates were combined, and the ethanol was recovered to obtain an extract □, which was dried for later use.

Red yeast rice powder (40 mesh) was refluxed and extracted three times with 95% ethanol for 2 hours, 1 hour and 1 hour respectively. The three filtrates were combined, and the ethanol was recovered to obtain extract □, which was dried for later use.

Dry extracts ① and ② are mixed in a ratio of 1:1. Experiments on regulating blood lipids, regulating blood pressure, regulating blood sugar and anti-atherosclerosis were carried out.

Example 5:

The total saponins of Panax notoginseng (100 mesh) and red yeast rice powder (100 mesh) are mixed evenly in a ratio of 1:10. Experiments on regulating blood lipids, regulating blood pressure, regulating blood sugar and anti-atherosclerosis were carried out.

The above examples are only for further illustrating the present invention, and the present invention is not limited by the examples.

Experimental Example 1: Study on Regulating Blood Lipid

experiment method:

1 Establishment of obese and high-fat rat models: weaned male rats with an average body weight of 110 g were fed a homemade high-fat and high-cholesterol diet for 47 days, and their weight gain and TC were significantly higher than those of the negative control group (P<0.01), indicating that the model was successful.

2 Lipid-lowering weight loss test: according to body weight and TC value, high-fat obesity rats were randomly divided into two groups, namely high-fat obesity control group (O group), test substance group, 10 rats in each group, negative control group ( O Group ¹ ) continues to be reserved. The test substance group was fed with the high-fat and high-cholesterol diet plus the test substance, the O group was fed with the simple high-fat and high-cholesterol diet, and the O ^{and 1} group were fed with common rat pellets for 30 days.

Blood lipid changes are as follows: (mg/100dl)

Group Number of mice (only) TC                                                    

O ¹ 5 47.3±5.0 47.1±18.± 28.2±6.4

O 10 98.4±21.± 233.2±88.1 19.6±2.0

Test substance 10 81.3±13.9 ^□□ 149.8±21.8 ^□ 21.6±4.5

□□: P<0.01 □: P<0.05 (compared with group O)

in conclusion

1. The test results show that the test substance (patent composition of the present invention) group is compared with the high-fat obesity control group (O group), and there is a very significant difference in reducing serum total cholesterol (TC), reducing serum triglyceride (TG ) difference has significant significance, but the difference in raising high-density lipoprotein-cholesterol (HDL-C) has no significant significance, indicating that the composition has a better effect of reducing TC and TG.

2. According to the test results, the daily dose of lovastatin is calculated as 0.6g, and the daily dose of lovastatin is further calculated as 4.5mg (calculated according to the content of lovastatin in red yeast rice as 1.5%).

3. According to Peking University Weixin Xuezhikang Capsules (production batch number: 20011209), each capsule contains no less than 2.5 mg of lovastatin, 2 capsules at a time, twice a day, and the daily dose of lovastatin for humans is at least 10.0 mg. mg.

4. The dose of lovastatin taken by humans every day, Xuezhikang Capsules is about twice that of the patented composition of the present invention. It can be seen that the components in the composition do have synergistic effects, and we will conduct in-depth research on the synergistic effects Pharmacodynamic research.

Claims (3)

1. A composition for preventing or treating cardiovascular and cerebrovascular diseases, which uses Panax notoginseng and red yeast rice as raw materials. Mix the weight ratio between them to prepare the composition. 2. The composition as claimed in claim 1, characterized in that: the fungus producing red yeast rice can be Monascus anka, Monacus purpureus, Monacus albidus, Monascus bucker ( Monacus barkeri), Monacus fulignosus, Monacus rubervam, Monacus rubiginosus, Monacus serorubescens and Monacus mucoroides A sort of. 3. The application of the composition according to claim 1, characterized in that the composition can be applied to health food or food additive.