CN1181879C - Analgestic plaster - Google Patents
Analgestic plaster Download PDFInfo
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- CN1181879C CN1181879C CNB021589291A CN02158929A CN1181879C CN 1181879 C CN1181879 C CN 1181879C CN B021589291 A CNB021589291 A CN B021589291A CN 02158929 A CN02158929 A CN 02158929A CN 1181879 C CN1181879 C CN 1181879C
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- 230000000202 analgesic effect Effects 0.000 title description 3
- 239000011505 plaster Substances 0.000 title description 2
- 239000003814 drug Substances 0.000 claims abstract description 24
- 201000008482 osteoarthritis Diseases 0.000 claims abstract description 19
- 208000003947 Knee Osteoarthritis Diseases 0.000 claims abstract description 15
- 239000000843 powder Substances 0.000 claims abstract description 14
- 241000628997 Flos Species 0.000 claims description 8
- 241000334161 Cercis chinensis Species 0.000 claims description 6
- 241000903946 Clematidis Species 0.000 claims description 6
- 208000002193 Pain Diseases 0.000 abstract description 19
- 230000000694 effects Effects 0.000 abstract description 14
- 238000002360 preparation method Methods 0.000 abstract description 9
- 230000017531 blood circulation Effects 0.000 abstract description 8
- 239000008187 granular material Substances 0.000 abstract description 5
- 239000002674 ointment Substances 0.000 abstract description 5
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 208000007101 Muscle Cramp Diseases 0.000 abstract description 2
- 208000005392 Spasm Diseases 0.000 abstract description 2
- 230000003213 activating effect Effects 0.000 abstract 2
- 241000227129 Aconitum Species 0.000 abstract 1
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 241000213006 Angelica dahurica Species 0.000 abstract 1
- 241000489492 Arisaema Species 0.000 abstract 1
- 241000132012 Atractylodes Species 0.000 abstract 1
- 244000020518 Carthamus tinctorius Species 0.000 abstract 1
- 235000003255 Carthamus tinctorius Nutrition 0.000 abstract 1
- 241001233914 Chelidonium majus Species 0.000 abstract 1
- 241000218158 Clematis Species 0.000 abstract 1
- 244000281702 Dioscorea villosa Species 0.000 abstract 1
- 241000202807 Glycyrrhiza Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 241001506304 Kadsura japonica Species 0.000 abstract 1
- 241000972673 Phellodendron amurense Species 0.000 abstract 1
- 244000299790 Rheum rhabarbarum Species 0.000 abstract 1
- 235000009411 Rheum rhabarbarum Nutrition 0.000 abstract 1
- 241001643409 Sinomenium acutum Species 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- LTINPJMVDKPJJI-UHFFFAOYSA-N iodinated glycerol Chemical compound CC(I)C1OCC(CO)O1 LTINPJMVDKPJJI-UHFFFAOYSA-N 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 210000000629 knee joint Anatomy 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000000988 bone and bone Anatomy 0.000 description 6
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- 230000001954 sterilising effect Effects 0.000 description 4
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- 229940126701 oral medication Drugs 0.000 description 3
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- 235000003143 Panax notoginseng Nutrition 0.000 description 2
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Abstract
The present invention belongs to the technical field medicine and relates to external application Chinese medicine preparation pain alleviating ointment for treating knee osteoarthritis. The external application Chinese medicine preparation pain alleviating ointment has one dose medicine ingredient prescriptions of 1000 to 5000g of kadsura root-bark, 400 to 800g of dahurian angelica, 300 to 600g of clematis root, 600 to 900g of safflower, 500 to 1000g of sinomenium acutum, 300 to 600g of pedate pinallia jackinthepulpit rhizome, 400 to 500g of angelica, 400 to 700g of smoked plum, 600 to 900g of nippon yam rhizome, 400 to 800g of xizi, 300 to 600g of common monkshood mother root, 500 to 900g of phellodendron bark, 300 to 800g of atractylodes rhizome, 500 to 1000g of paniculate swallowwort root, 300 to 500g of kusnezoff monkshood root, 400 to 700g of rhubarb and 400 to 4500g of radix glycyrrhiza. The present invention has the preparation method: the medicine prescriptions are taken according to weight percent, dried, sterilized and pulverized into fine powder with about 130 meshes of granules, and 200g of the fine powder is packed into each bag. The present invention uses various Chinese medicine optimized prescriptions and has the effects on activating blood circulation to dispel stasis, alleviating pain, dispelling wind, eliminating dampness, activating blood circulation to dredge the meridian passage, eliminating muscle spasm, alleviating pain and improving functions. The external application Chinese medicine preparation pain alleviating ointment is manufacture into an external application preparation with convenient use, simple preparation process and low cost. Clinical observation shows that the qualified treating rate is 89.96%, and the total effective rate is 97.98%; the shortest treatment time is 15 days, and the longest treatment time is 72 days; the present invention has the advantages of strengthened therapeutic effect and low relapse rate.
Description
Technical field
The present invention is a field of pharmaceutical technology, relates to a kind of external Chinese powder medicine for the treatment of knee osteoarthritis.
Background technology
Knee osteoarthritis is common ailment of middle-aged and old, frequently-occurring disease.Main clinical manifestation is that the gonalgia is stiff, swelling and dysfunction.At present, the cause of disease to osteoarthritis is not clear and definite fully as yet both at home and abroad.Though Therapeutic Method is many but effect is all unsatisfactory, mainly contains naturopathy and oral drug therapy etc.Naturopathy needs the time longer, and the patient who has can not accept, and the oral drug therapy side effect is bigger, and curative effect is slow.The method of ZHITONG GAO treatment knee osteoarthritis is our accumulation of clinical experience for many years, with dispel the wind, collateral dredging, promoting blood circulation to remove blood stasis analgesic pure Chinese medicinal preparation.The traditional Chinese medical science is in the difference of methods such as determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, prescription, dosage form, processing technique, and curative effect is widely different.Chinese patent 99120466.2 is disclosed to be a kind of analgesic plaster for osteoarthritis, it is with RHIZONA GASTRODIAE, Radix Notoginseng, the system Cortex Eucommiae, Herba Epimedii, eupolyphaga, Radix Aconiti, Radix Aconiti Kusnezoffii, Scorpio, Scolopendra, Radix Polygoni Multiflori, Squama Manis, Hirudo, Olibanum (processed), Myrrha (processed), Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Salviae Miltiorrhizae, Semen Persicae, Radix Paeoniae Rubra, Caulis Spatholobi, Flos Carthami, Sanguis Draxonis, Radix Dipsaci, Herba Taxilli, Cortex Moutan, Rhizoma Curcumae Longae, the river Radix Achyranthis Bidentatae, Cortex Acanthopancis, Zaocys, Corium elephatis, Crinis Carbonisatus, Herba Ephedrae, Herba Asari, Radix Saposhnikoviae, Radix Angelicae Pubescentis, the Radix Angelicae Dahuricae, Rhizoma Arisaematis, Radix Et Rhizoma Rhei, Radix Puerariae, rice is honest, Borneolum Syntheticum, Chinese herbal medicine such as Semen Sinapis Albae are formed, and the pain that osteoarthritis is caused has the effect of treatment or relief of symptoms.Chinese patent 01131249.1 is disclosed to be a kind of pain-stopping ointment for bone, and it is a kind of medicine with functions such as blood circulation promoting and blood stasis dispelling, expelling wind and cold, Shujin bone strengthening, reducing swelling and alleviating pain.The pain-stopping ointment for bone of forming by natural Chinese medicinal herb such as Radix Angelicae Sinensis, Flos Carthami, Radix Notoginseng, Olibanum, Myrrha, Sanguis Draxonis, Herba speranskiae tuberculatae, Eupolyphaga Seu Steleophaga, Rhizoma Et Radix Notopterygii, Radix Angelicae Pubescentis, Carapax Trionycis, Ramulus Cinnamomi, Borneolum Syntheticums.
Summary of the invention
The objective of the invention is to be more effective treatment knee osteoarthritis, a kind of external Chinese powder medicine for the treatment of knee osteoarthritis is provided in order to overcome the shortcoming that above-mentioned naturopathy and oral drug therapy etc. exist.
The present invention is a kind of external Chinese powder medicine for the treatment of knee osteoarthritis, content Description:
A kind of external Chinese powder medicine for the treatment of knee osteoarthritis of the present invention, it is characterized in that: it is made up of the component of following weight: Cortex cercis chinensis 1000～5000g, the Radix Angelicae Dahuricae 400～800g, Radix Clematidis 300～600g, Flos Carthami 600～900g, Radix Stephaniae Tetrandrae 500～1000g, Rhizoma Arisaematis 300～600g, Radix Angelicae Sinensis 400～500g, Fructus Mume 400～700g, Rhizoma Dioscoreae Nipponicae 600～900g, Herba Asari 400～800g, Radix Aconiti 300～600g, Cortex Phellodendri 500～900g, Rhizoma Atractylodis 300～800g, Radix Cynanchi Paniculati 500～1000g, Radix Aconiti Kusnezoffii 300～500g, Radix Et Rhizoma Rhei 400～700g and Radix Glycyrrhizae 400～4500g.
The external Chinese powder medicine of treatment knee osteoarthritis is made by following method: get it filled by weight, dry sterilization, be ground into granule 130 purpose fine powders, packing 200g/ bag tempers into paste during use.
The present invention is a kind of external Chinese powder medicine for the treatment of knee osteoarthritis, has functions dispelling wind and clearing away cold, removing dampness, and the effect of dredging the meridian, regulating QI to relieve pain is made external preparation, easy to use, preparation technology is simple, with low cost.Clinical trial of the present invention is finished, and 2280 routine osteoarthritis patients have been carried out the determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs clinical practice of traditional Chinese medical science typing, and wherein the course of disease is the longest 8 years, 4 the shortest weeks.Anemofrigid-damp arthralgia resistance type 1582 examples, QI and blood two empty type 315 examples, deficiency of both the liver and kidney type 279 example and bones and muscles injury type 104 examples.
Criterion of therapeutical effect: do efficacy evaluation according to " People's Republic of China's Chinese medicine industry standard-traditional Chinese medical science disease is diagnosed criterion of therapeutical effect 94 years ".
Recovery from illness: a pain disappears; B knee joint mobility is normal; The swelling of c knee joint disappears; D erythrocyte sedimentation rate (ESR) recovery normal level (woman＜20mm/h, the man＜10mm/h).
Produce effects: idol has pain during the activity of a knee joint; B knee joint mobility (bending and stretching) recovers＞30% before the treatment; The swelling of c knee joint obviously alleviates (Zhou Jing descends 10% before the treatment) before the treatment; D erythrocyte sedimentation rate (ESR) is not higher than normal 10mm/h.
Effectively: the pain during activity of a knee joint; B knee joint mobility (bending and stretching) recovers＞20% before the treatment; The swelling of c knee joint obviously alleviates (Zhou Jing descends 5% before the treatment) before the treatment; D erythrocyte sedimentation rate (ESR) is not higher than normal 20mm/h.
Invalid: symptom and sign are with the preceding no change of treatment.
| Pattern of syndrome | The example number | Recovery from illness | Account for % | Produce effects | Account for % | Effectively | Account for % | Invalid | Account for % |
| The anemofrigid-damp arthralgia resistance type | 1582 | 1270 | 80.28 | 138 | 8.72 | 159 | 10.05 | 15 | 0.95 |
| QI and blood two empty types | 315 | 201 | 63.81 | 93 | 29.52 | 12 | 3.80 | 9 | 2.86 |
| The deficiency of both the liver and kidney type | 279 | 152 | 54.48 | 121 | 43.37 | 2 | 0.72 | 5 | 1.80 |
| The bones and muscles injury type | 104 | 68 | 65.39 | 8 | 7.70 | 10 | 9.62 | 18 | 17.31 |
| Add up to | 2280 | 1691 | 74.17 | 360 | 15.79 | 183 | 8.03 | 47 | 2.06 |
Through clinical treatment produce effects 2051 examples, obvious effective rate 89.96%; Total effective 2234 examples, total effective rate is 97.98%.What treatment time was the shortest is 15 days, and the longest 72 days, the efficacy consolidation incidence rate was lower, checks 1270 examples with examining after 4 months to 2 years, and 53 example recurrences are arranged, and the state of an illness is preceding light than treatment, and relapse rate is for checking 4.17% of case with examining.
The specific embodiment
Embodiment 1
Go to a doctor in Tanggangzi Hospital year October in January calendar year 2001～2002, anemofrigid-damp arthralgia resistance type knee osteoarthritis patient 1582 examples, the prescription of seance amount medication is: Cortex cercis chinensis 3000g, Radix Angelicae Dahuricae 600g, Radix Clematidis 500g, Flos Carthami 800g, Radix Stephaniae Tetrandrae 800g, Rhizoma Arisaematis 400g, Radix Angelicae Sinensis 500g, Fructus Mume 400g, Rhizoma Dioscoreae Nipponicae 700g, Herba Asari 400g, Radix Aconiti 400g, Cortex Phellodendri 500g, Rhizoma Atractylodis 500g, Radix Cynanchi Paniculati 500g, Radix Aconiti Kusnezoffii 400g, Radix Et Rhizoma Rhei 400g and Radix Glycyrrhizae 400g.With the said medicine dry sterilization, be ground into granule 130 purpose fine powders, packing 200g, water reconciles into paste, and spreads on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increases temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 99.05% through the treatment total effective rate.
Embodiment 2
Go to a doctor in Tanggangzi Hospital in January, 2000～June, QI and blood two empty type knee osteoarthritis patient 315 examples are got: Cortex cercis chinensis 4000g, Radix Angelicae Dahuricae 800g, Radix Clematidis 600g, Flos Carthami 900g, Radix Stephaniae Tetrandrae 700g, Rhizoma Arisaematis 400g, Radix Angelicae Sinensis 400g, Fructus Mume 600g, Rhizoma Dioscoreae Nipponicae 700g, Herba Asari 800g, Radix Aconiti 500g, Cortex Phellodendri 700g, Rhizoma Atractylodis 500g, Radix Cynanchi Paniculati 800g, Radix Aconiti Kusnezoffii 400g, Radix Et Rhizoma Rhei 600g and Radix Glycyrrhizae 4500g.With the said medicine dry sterilization, be ground into granule 130 purpose fine powders, packing 200g, water reconciles into paste, and spreads on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increases temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 97.14% through the treatment total effective rate.
Embodiment 3
Go to a doctor deficiency of both the liver and kidney type knee osteoarthritis patient 279 examples in Tanggangzi Hospital in July, 2000～December.Get: Cortex cercis chinensis 5000g, Radix Angelicae Dahuricae 400g, Radix Clematidis 600g, Flos Carthami 900g, Radix Stephaniae Tetrandrae 1000g, Rhizoma Arisaematis 600g, Radix Angelicae Sinensis 400g, Fructus Mume 700g, Rhizoma Dioscoreae Nipponicae 900g, Herba Asari 400g, Radix Aconiti 600g, Cortex Phellodendri 900g, Rhizoma Atractylodis 800g, Radix Cynanchi Paniculati 1000g, Radix Aconiti Kusnezoffii 500g, Radix Et Rhizoma Rhei 400g and Radix Glycyrrhizae 800g.With the said medicine dry sterilization, be ground into granule 130 purpose fine powders, packing 200g, water reconciles into paste, and spreads on the affected part after heating with hot water bag, the lid layer soft plastic cloth covers two layers of towel again, increases temperature with hot water bag, applied 2 hours every day.Make medicine act on body by skin by heating power, functions dispelling wind and clearing away cold, removing dampness, dredging the meridian, regulating QI to relieve pain reach the purpose of curing the disease.Reach 99.20% through the treatment total effective rate.
Prove according to pharmacological research: Cortex cercis chinensis has promoting blood circulation to restore menstrual flow, subduing swelling and detoxicating, controls bones and muscles pain, anemofrigid-damp arthralgia, apathy; Radix Stephaniae Tetrandrae, Radix Clematidis, Radix Cynanchi Paniculati have blood circulation promoting and blood stasis dispelling, pain relieving, expelling wind and removing dampness effect; Flos Carthami, Radix Et Rhizoma Rhei, Radix Angelicae Sinensis have the active effect of promoting blood circulation to restore menstrual flow.The present invention is the comprehensive prescription of the rule of treatment with blood circulation promoting and blood stasis dispelling, dredging the meridian.By eliminating muscle spasm, improve local blood circulation and histotrophic nutrition, ease the pain, increase range of motion.
Claims (1)
1, a kind of external Chinese powder medicine for the treatment of knee osteoarthritis, it is characterized in that: it is made up of the component of following weight: Cortex cercis chinensis 1000～5000g, the Radix Angelicae Dahuricae 400～800g, Radix Clematidis 300～600g, Flos Carthami 600～900g, Radix Stephaniae Tetrandrae 500～1000g, Rhizoma Arisaematis 300～600g, Radix Angelicae Sinensis 400～500g, Fructus Mume 400～700g, Rhizoma Dioscoreae Nipponicae 600～900g, Herba Asari 400～800g, Radix Aconiti 300～600g, Cortex Phellodendri 500～900g, Rhizoma Atractylodis 300～800g, Radix Cynanchi Paniculati 500～1000g, Radix Aconiti Kusnezoffii 300～500g, Radix Et Rhizoma Rhei 400～700g and Radix Glycyrrhizae 400～4500g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021589291A CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021589291A CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1424095A CN1424095A (en) | 2003-06-18 |
| CN1181879C true CN1181879C (en) | 2004-12-29 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021589291A Expired - Fee Related CN1181879C (en) | 2002-12-27 | 2002-12-27 | Analgestic plaster |
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| Country | Link |
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| CN (1) | CN1181879C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316229A (en) * | 2013-07-04 | 2013-09-25 | 虞攀峰 | Medicine for treating knee osteoarthropathy |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288238A (en) * | 2015-11-19 | 2016-02-03 | 山东明仁福瑞达制药股份有限公司 | Preparation method of blood-activating and stasis-resolving traditional Chinese medicine composition containing 22 components and paste thereof |
| CN107184720A (en) * | 2017-05-26 | 2017-09-22 | 广州智润生物制药科技有限公司 | It is a kind of to treat patch of gonitis and preparation method thereof |
| CN114699363B (en) * | 2022-06-08 | 2022-11-04 | 江西中医药大学附属医院 | A kind of traditional Chinese medicine wax mud for osteoarthritis and preparation method thereof |
-
2002
- 2002-12-27 CN CNB021589291A patent/CN1181879C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103316229A (en) * | 2013-07-04 | 2013-09-25 | 虞攀峰 | Medicine for treating knee osteoarthropathy |
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| CN1424095A (en) | 2003-06-18 |
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