CN1179975A - A kind of pharmaceutical composition for treating osteoporosis - Google Patents
A kind of pharmaceutical composition for treating osteoporosis Download PDFInfo
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- CN1179975A CN1179975A CN 97116975 CN97116975A CN1179975A CN 1179975 A CN1179975 A CN 1179975A CN 97116975 CN97116975 CN 97116975 CN 97116975 A CN97116975 A CN 97116975A CN 1179975 A CN1179975 A CN 1179975A
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- 208000001132 Osteoporosis Diseases 0.000 title claims abstract description 16
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 20
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims abstract description 12
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 12
- 235000009411 Rheum rhabarbarum Nutrition 0.000 claims abstract description 12
- 229910052802 copper Inorganic materials 0.000 claims abstract description 12
- 239000010949 copper Substances 0.000 claims abstract description 12
- 235000008434 ginseng Nutrition 0.000 claims abstract description 12
- 244000144730 Amygdalus persica Species 0.000 claims abstract description 8
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- 235000018735 Sambucus canadensis Nutrition 0.000 claims abstract description 8
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- 235000007124 elderberry Nutrition 0.000 claims abstract description 8
- 235000008995 european elder Nutrition 0.000 claims abstract description 8
- 241000405414 Rehmannia Species 0.000 claims abstract description 7
- 244000299790 Rheum rhabarbarum Species 0.000 claims abstract 3
- 244000151637 Sambucus canadensis Species 0.000 claims abstract 3
- 241000208340 Araliaceae Species 0.000 claims description 11
- 241000237502 Ostreidae Species 0.000 claims description 11
- 235000020636 oyster Nutrition 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 9
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- 244000132619 red sage Species 0.000 claims description 7
- 235000019687 Lamb Nutrition 0.000 claims description 5
- WTPPRJKFRFIQKT-UHFFFAOYSA-N 1,6-dimethyl-8,9-dihydronaphtho[1,2-g][1]benzofuran-10,11-dione;1-methyl-6-methylidene-8,9-dihydro-7h-naphtho[1,2-g][1]benzofuran-10,11-dione Chemical compound O=C1C(=O)C2=C3CCCC(=C)C3=CC=C2C2=C1C(C)=CO2.O=C1C(=O)C2=C3CCC=C(C)C3=CC=C2C2=C1C(C)=CO2 WTPPRJKFRFIQKT-UHFFFAOYSA-N 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 2
- 239000002994 raw material Substances 0.000 claims 1
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- 241000173529 Aconitum napellus Species 0.000 abstract 1
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 1
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- QMGVPVSNSZLJIA-UHFFFAOYSA-N Nux Vomica Natural products C1C2C3C4N(C=5C6=CC=CC=5)C(=O)CC3OCC=C2CN2C1C46CC2 QMGVPVSNSZLJIA-UHFFFAOYSA-N 0.000 abstract 1
- 244000131316 Panax pseudoginseng Species 0.000 abstract 1
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Abstract
Description
本发明是一种治疗骨质疏松症的药物组合物，该组合物的组成为我国的传统中草药，对骨质疏松症的治疗和预防具有良好的功效，本发明还提供了以该组合物制备而成的药剂，属于中药领域，The invention is a pharmaceutical composition for treating osteoporosis. The composition is traditional Chinese herbal medicine in my country, which has good efficacy in the treatment and prevention of osteoporosis. The invention also provides The medicament formed belongs to the field of traditional Chinese medicine,
随着现代生活水平的提高，人口寿命逐渐增长，老年人口越来越多，由此带来的退行性生理疾病-原发性骨质疏松症已经成为老年健康的重要疾病之一。骨质疏松症是一种老年病，常见病，目前国内尚无特效的中药制剂。骨质疏松症的特征是骨量低下，骨组织微结构退化导致骨脆性增加，极易造成腰椎压缩性骨折、股骨颈骨折及手腕部、桡骨骨折。这些骨折，尤其是腰椎骨折，往往在没有明显外力作用下发生，常常表现突然腰背剧痛始被发现。随着人口寿命的增长，老年人数的增多，这种病的危害就越来越严重。因此，寻找一种有效预防和治疗骨质疏松症的中药，是当前医学界的重要课题之一。With the improvement of modern living standards, the life expectancy of the population is gradually increasing, and the elderly population is increasing. The resulting degenerative physiological disease-primary osteoporosis has become one of the important diseases of the health of the elderly. Osteoporosis is a kind of senile disease, a common disease, and there is no specific Chinese medicine preparation in China at present. Osteoporosis is characterized by low bone mass and microarchitectural degradation of bone tissue leading to increased bone fragility, which can easily cause lumbar vertebral compression fractures, femoral neck fractures, wrist and radius fractures. These fractures, especially lumbar fractures, often occur without obvious external force, and often manifest as sudden severe back pain. Along with the growth of population life expectancy, the increase of old people's number, the harm of this disease is just more and more serious. Therefore, finding a kind of Chinese medicine for effectively preventing and treating osteoporosis is one of the important topics in the current medical circle.
本发明目的是开发一种治疗骨质疏松症的药物组合物。The purpose of the present invention is to develop a pharmaceutical composition for treating osteoporosis.
根据中医“肾主骨”的理论，骨质疏松症患者肾虚是病之根本。治病必求于本，且肾虚又有肾阴虚、肾阴虚之分。运用中医辩证施治的原则，按照全国关于肾阴虚、肾阳虚诊断标准，对本病肾阳虚者，补肾阳，填精养血，壮骨舒筋，活血祛瘀止痛。发明人在临床实践中通过大量病例总结，研制出了治疗骨质疏松症偏肾阳虚的药物。According to the theory of "kidney governs bones" in traditional Chinese medicine, kidney deficiency is the root of the disease in patients with osteoporosis. Curing must seek at the root, and kidney deficiency can be divided into kidney-yin deficiency and kidney-yin deficiency. Using the principle of TCM dialectical treatment, in accordance with the national diagnostic criteria for kidney yin deficiency and kidney yang deficiency, for those with kidney yang deficiency in this disease, tonify kidney yang, replenish essence and nourish blood, strengthen bones and relax tendons, promote blood circulation, remove blood stasis and relieve pain. The inventor has developed a medicine for treating osteoporosis partial kidney yang deficiency through a large number of case studies in clinical practice.
本发明药物组合物按重量份计其组成是：The composition of the pharmaceutical composition of the present invention is in parts by weight:
人参 20-80份Ginseng 20-80 parts
羊骨 20-80份Lamb bone 20-80 parts
熟地 20-80份Rehmannia 20-80 parts
活鳝鱼 80-120份Live eel 80-120 servings
当归 30-80份Angelica 30-80 servings
赤芍 30-80份Paeoniae Rubra 30-80 parts
丹参 30-80份Danshen 30-80 parts
接骨木 80-120份Elderberry 80-120 servings
自然铜 80-120份Natural copper 80-120 parts
蟹 80-120份Crab 80-120 servings
大黄 30-80份Rhubarb 30-80 parts
炙马钱子 30-80份Roasted horse money 30-80 parts
桃仁 10-40份10-40 parts of peach kernel
红花 10-40份Safflower 10-40 parts
川芎 30-80份Chuanxiong 30-80 parts
炙川乌 30-80份Zhichuan black 30-80 servings
牡蛎 80-120份Oysters 80-120 servings
本发明所述的药物组合物其优选重量配比为：Its preferred weight ratio of the pharmaceutical composition of the present invention is:
人参 50份Ginseng 50 servings
羊骨 50份Lamb bones 50 parts
熟 50份Cooked 50 servings
活鳝鱼 100份Live eel 100 servings
当归 50份Angelica 50 servings
赤芍 50份Radix Paeoniae Alba 50 parts
丹参 50份Danshen 50 parts
接骨木 100份elderberry 100 servings
自然铜 100份Natural copper 100 parts
蟹 100份Crab 100 servings
大黄 50份rhubarb 50 parts
炙马钱子 50份Roasted horse money 50 parts
桃仁 15份15 servings of peach kernels
红花 15份15 servings of safflower
川芎 50份Chuanxiong 50 parts
炙川乌 50份Zhichuan black 50 servings
牡蛎 100份Oysters 100 servings
本发明所述的药物组合物，可以按照常规的制剂工艺，制备成任何一种适合于临床上使用的药物剂型。如，丸剂、片剂、胶囊剂、散记、糖浆剂、口服液、混悬剂、颗粒剂等。The pharmaceutical composition of the present invention can be prepared into any pharmaceutical dosage form suitable for clinical use according to conventional preparation techniques. For example, pills, tablets, capsules, powders, syrups, oral liquids, suspensions, granules, etc.
在制备成本发明上述的药物剂型过程中，可以加入常规的药物赋性剂，例如，崩解剂、粘合剂、调味剂、防腐剂、填充剂、增溶剂、助溶剂、润滑剂、色素等。During the preparation of the above-mentioned pharmaceutical dosage forms of the present invention, conventional pharmaceutical excipients, such as disintegrants, binders, flavoring agents, preservatives, fillers, solubilizers, solubilizers, lubricants, pigments, etc., can be added.
本发明药物丸剂(商品名为勇骨丹)的制备方法是：The preparation method of medicine pill of the present invention (trade name is brave bone pill) is:
将人参、羊骨、活鳝鱼、蟹速冻干燥，研为粉末。自然铜、牡蛎、大黄、炙川乌、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上述药粉混合，炼蜜为丸，每丸重6克。Ginseng, mutton bone, live eel and crab are quick-freeze-dried and ground into powder. Natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi were ground into fine powder, and the rest of the medicines were made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above-mentioned medicinal powder, and refined into honey to make pills, each weighing 6 grams.
本发明药物的功效是：补肾阳、填精补血、壮骨舒筋、活血化瘀。The effects of the medicine of the present invention are: tonifying kidney yang, replenishing essence and blood, strengthening bones and relaxing tendons, promoting blood circulation and removing blood stasis.
主治：肾阳虚型骨质疏松症。Indications: kidney yang deficiency type osteoporosis.
临床应用：骨质疏松、腰脊冷痛、屈伸不利、骨折未愈兼见畏寒肢冷、自汗、面色恍白、脉沉迟者，每次服一丸，每日三次，饭后黄酒100毫升送服，30天为一疗程。Clinical application: Osteoporosis, cold pain in the waist and spine, poor flexion and extension, unhealed fractures and chills in the limbs, spontaneous sweating, pale complexion, deep and slow pulse, take one pill each time, three times a day, rice wine 100 after meals Milliliter delivery service, 30 days as a course of treatment.
自1995年至1997年，应用本发明药物治疗骨质疏松症病人30例。30例病人骨X线平片显示：胸椎、髋骨均有不同程度骨密度降低。其中，6例腰椎压缩性骨折，4例股骨颈骨折，1例桡骨骨折，1例髋骨骨折。30例病人均有不同程度腰背疼痛病史、膝关节及髋部疼痛病史。From 1995 to 1997, 30 patients with osteoporosis were treated with the medicine of the present invention. The bone X-ray plain films of 30 patients showed that the bone density of the thoracic spine and hip bones decreased in varying degrees. Among them, there were 6 cases of lumbar compression fracture, 4 cases of femoral neck fracture, 1 case of radial fracture, and 1 case of hip fracture. All 30 patients had medical history of low back pain, knee joint and hip pain in different degrees.
对治疗结果的疗效评定标准是：The curative effect evaluation standard of treatment result is:
显效为用药后疼痛完全消失，活动功能显著增进；Significant effect refers to the complete disappearance of pain after medication, and significant improvement in activity function;
有效为用药后疼痛减轻，活动功能改善；It is effective for pain relief and improvement of activity function after medication;
无效为用药后疼痛未减轻，仍需服用其他药物。Ineffective means that the pain has not been alleviated after taking the medicine, and other medicines still need to be taken.
按上述疗效评价标准，治疗结果如下表：
本发明药物组合物治疗骨质疏松症总有效率93％。The total effective rate of the pharmaceutical composition of the present invention in treating osteoporosis is 93%.
实施例1Example 1
人参50克 羊骨50克 活鳝鱼100克当归50克50 grams of ginseng 50 grams of sheep bone 100 grams of live eel 50 grams of angelica
赤芍50克 川芎50克 熟地50克 接骨木100克50 grams of red peony, 50 grams of Chuanxiong, 50 grams of rehmannia, 100 grams of elderberry
自然铜100克蟹100克 牡蛎100克 大黄50克Natural Copper 100g Crab 100g Oyster 100g Rhubarb 50g
炙川乌50克 炙马钱子50克丹参50克 桃仁15克50 grams of Zhichuan black, 50 grams of roasted horse money, 50 grams of salvia miltiorrhiza, 15 grams of peach kernels
红花 15克Safflower 15g
按照处方量取人参、羊骨、活鳝鱼、蟹速冻干燥，为末，保持生物活性。将自然铜、牡蛎、大黄、炙川乌、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，制成100丸，每丸重6克。Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.
实施例2Example 2
人参60克 羊骨30克 活鳝鱼80克当归70克60 grams of ginseng 30 grams of sheep bone 80 grams of live eel 70 grams of angelica
赤芍30克 川芎40克 熟地40克 接骨木80克Radix Paeoniae Rubra 30g Chuanxiong 40g Rehmannia Rehmanniae 40g Elderberry 80g
自然铜90克蟹90克 牡蛎90克 大黄40克Natural Copper 90g Crab 90g Oyster 90g Rhubarb 40g
炙川乌60克炙马钱子50克丹参40克 桃仁20克60 grams of Zhichuan black, 50 grams of roasted horse money, 40 grams of salvia miltiorrhiza, 20 grams of peach kernels
红花 25克Safflower 25g
按照处方量取人参、羊骨、活鳝鱼、蟹速冻干燥，为末，保持生物活性。将自然铜、牡蛎、大黄、炙川乌、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，制成100丸，每丸重6克。Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.
实施例3Example 3
人参90克 羊骨60克 活鳝鱼100克当归40克Ginseng 90g Lamb bone 60g Live eel 100g Angelica 40g
赤芍50克 川芎50克 熟地80克 接骨木120克50 grams of red peony, 50 grams of Chuanxiong, 80 grams of rehmannia, 120 grams of elderberry
自然铜90克蟹100克 牡蛎100克 大黄30克Natural Copper 90g Crab 100g Oyster 100g Rhubarb 30g
炙川乌40克炙马钱子40克丹参80克 桃仁30克40 grams of Zhichuan black, 40 grams of roasted horse money, 80 grams of salvia miltiorrhiza, 30 grams of peach kernels
红花 20克Safflower 20g
按照处方量取人参、羊骨、活鳝鱼、蟹速冻干燥，为末，保持生物活性。将自然铜、牡蛎、大黄、炙川乌、炙马钱子研细末，余下诸药按药典制剂通则规定制成清膏，然后与上药粉混合，炼蜜为丸，制成100丸，每丸重6克。Take ginseng, sheep bone, live eel and crab according to the prescription and freeze-dry them quickly to keep biological activity. Grind natural copper, oyster, rhubarb, Zhichuanwu, and Zhinxuezi into fine powder, and the rest of the medicines are made into a clear ointment according to the general principles of pharmacopoeia preparations, then mixed with the above medicinal powder, refined into honey, and made into 100 pills. Pills weigh 6 grams.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116975A CN1059115C (en) | 1997-10-06 | 1997-10-06 | A kind of pharmaceutical composition for treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN97116975A CN1059115C (en) | 1997-10-06 | 1997-10-06 | A kind of pharmaceutical composition for treating osteoporosis |
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| Publication Number | Publication Date |
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| CN1179975A true CN1179975A (en) | 1998-04-29 |
| CN1059115C CN1059115C (en) | 2000-12-06 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN97116975A Expired - Fee Related CN1059115C (en) | 1997-10-06 | 1997-10-06 | A kind of pharmaceutical composition for treating osteoporosis |
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| CN (1) | CN1059115C (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181487B (en) * | 2007-11-21 | 2010-06-23 | 朱强 | Chinese medicine composition orally taken for curing osteosporosis |
-
1997
- 1997-10-06 CN CN97116975A patent/CN1059115C/en not_active Expired - Fee Related
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101181487B (en) * | 2007-11-21 | 2010-06-23 | 朱强 | Chinese medicine composition orally taken for curing osteosporosis |
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| CN1059115C (en) | 2000-12-06 |
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