CN116869190A - CoQ capable of rapidly relieving altitude stress 10 /O 2 Preparation method and application of explosion beads - Google Patents

Abstract

The present invention relates to the technical field of food raw material production, in particular to the mild explosive release of oxygen, and more specifically to a preparation method and application of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness. In the present invention, through four steps of glue preparation, bead making, secondary oxygenation and drying, a CoQ ₁₀ /O ₂ explosive bead that can quickly alleviate altitude sickness is prepared. The CoQ ₁₀ /O ₂ popping beads in the present invention have a moderate diameter and are easy to carry, which not only broadens the application field of coenzyme Q ₁₀ , but also can effectively replace oxygen bags and ventilators, and can bring convenience to people living on the plateau to a great extent. .

Description

Preparation method and application of CoQ10/O2 explosive beads that can quickly alleviate altitude sickness

Technical field

The present invention relates to the technical field of food raw material production, in particular to the mild explosive release of oxygen, and more specifically to a preparation method and application of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness.

Background technique

Altitude Sickness refers to a series of symptoms caused by rapid changes in human blood oxygen after humans reach a certain altitude (generally more than 2,700 meters), combined with environmental factors such as falling temperatures, drying air, low air pressure, and ultraviolet radiation. Functional metabolism changes. The main symptoms are headache, dizziness, dizziness, tinnitus, and fatigue. In severe cases, symptoms such as chest tightness, dyspnea, nausea, vomiting, palpitation, and edema may also occur. In medicine, symptomatic treatment is generally based on the specific clinical manifestations of patients with altitude sickness: those with mild symptoms are generally given oxygen therapy; moderate and severe patients use high-flow nasal cannula or mask intermittent oxygen; for patients with severe altitude sickness such as cerebral edema and pulmonary edema, Patients who respond are usually immediately rescued on the spot and assisted with ventilator ventilation.

Although patients with mild altitude sickness can recover on their own, no matter how mild the symptoms are, they should be diagnosed and treated early after discovery to prevent further development of the disease. If not treated in time, not only may the duration of altitude sickness be prolonged, but secondary altitude sickness may occur. Pulmonary edema and high-altitude cerebral edema are life-threatening.

VOSviewer software was used to conduct co-occurrence analysis on publications extracted from journals indexed by Scopus, such as collaboration network, productivity and keywords. It was found that most of the articles related to altitude sickness were published in the journal "Altitude Medicine and Biology", and the research focus was Distributed in adaptation mechanisms (37.1%, mainly hypoxia and respiratory function), acute mountain sickness (18.4%) and pulmonary edema (14.7%). Among the top ten institutions, the University of Colorado and the University of Cayetano Heredia of Peru together contributed more than 100 publications, but there are no commercially available products developed by these two universities that can be used for rapid Mature product for alleviating altitude sickness. (Zila-Velasque, J.P., et al. (2023). "Adaptation and altitudesickness: A 40-year bibliometric analysis and collaborative networks." FrontPublic Health 11:1069212.). At present, scientific research results on altitude sickness continue to grow, but most of them remain at the academic research level. There are few products that can effectively prevent and efficiently treat altitude sickness. This is why it is not difficult to explain that many tourists have to bring oxygen bags or even oxygen bottles. Traveled and studied in high altitude areas like Tibet.

Based on the above content, the current development of a portable, affordable product that can effectively prevent and treat altitude sickness is of great significance to boosting the local economy in plateau areas and protecting the lives and health of people living in high-altitude areas.

Contents of the invention

In order to solve the problems in the prior art, the present invention provides a method for preparing CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness, including the following steps: glue preparation, bead making, secondary oxygenation and drying. .

Specifically, the rubber is a wall material rubber equipped with explosive beads. The main components are edible gelatin, food-grade plasticizer, food-grade embedded water-soluble CoQ ₁₀ and purified water.

Specifically, the glue preparation is completed in the glue preparation kettle. First, the food-grade embedded water-soluble CoQ ₁₀ is completely dissolved with purified water to obtain the CoQ ₁₀ liquid, and then edible gelatin and food-grade plasticizer are added to the CoQ ₁₀ liquid at one time. (There are no special requirements for the order in which edible gelatin and food-grade plasticizers are added).

Specifically, the manufacturer of the edible gelatin is Anhui Fengyuan Gelatin Co., Ltd., the chemical component name of the food-grade plasticizer is sorbitol, the manufacturer is Zhejiang Huakang Pharmaceutical Co., Ltd., and the food-grade embedded water-soluble CoQ ₁₀ is a company-made product, and purified water is a company-made product.

Specifically, the dosage of sorbitol is 0.2 to 0.7 mass times that of edible gelatin. The lower the dosage, the harder the wall material of the exploding beads will be, and conversely, the softer it will be. In order to obtain better oxygen explosion release effect,

Specifically, the dosage of sorbitol is preferably 0.3 mass times that of edible gelatin. Other dosages cannot achieve a good oxygen explosion release effect.

Specifically, the food-grade ready-to-eat-grade water-soluble CoQ ₁₀ embedded with water-soluble CoQ ₁₀ has a dosage of 0.001 mass times that of edible gelatin, which can improve the blood and oxygen supply to the heart and prevent ischemia and hypoxia. The cardiomyocytes and brain cells are damaged. The dosage is calculated based on the recommended daily dosage of CoQ ₁₀ by the American College of Cardiologists for people over 65 years old. It must be evenly dispersed during the glue preparation process, otherwise each capsule will burst. The total amount of CoQ ₁₀ contained in the bead wall material is not uniform. In order to ensure that CoQ ₁₀ can be evenly dispersed in the glue preparation process, embedded water-soluble CoQ ₁₀ must be used, because the water-soluble characteristics of CoQ ₁₀ can completely dissolve it in the glue preparation process. Purified water involved in the glue process.

Specifically, the amount of purified water used is 0.8-1.2 mass times that of food-grade gelatin, which can be adjusted according to the specific gel preparation effect. The preferred amount is 0.9 mass times that of food-grade gelatin.

More specifically, the glue dispensing kettle is made of 316L stainless steel and is equipped with a screw vacuum pump including a condenser and a receiving tank. The equipment is all common equipment on the market, and the manufacturer does not make special restrictions.

More specifically, the glue dispensing temperature is 60-65°C. Too high a temperature will cause gelatin to hydrolyze, and too low a temperature is not conducive to uniform mixing and dispersion of materials. After the glue is mixed, vacuum degassing (-0.05~-0.08MPa) begins after all the components are added to the glue mixing kettle. The degree of vacuum increases from small to large to prevent the glue from boiling. Vacuum degassing is completed until no obvious bubbles are released on the glue surface and the glue surface flows in a honeycomb shape. The completion of degassing is considered as the completion of glue preparation. The glue obtained after the glue preparation is completed needs to be stored at a temperature of 50-55°C for later use. If the glue temperature is lower than 50°C, the fluidity of the glue will become poor and is not conducive to bead making. The moisture of the glue should be controlled at 20-25%. If the moisture is too low, it will affect the rubber stitching in the next meshing process. If the moisture is too high, the glue will not be formed and the next meshing process will not proceed normally.

Specifically, the bead making process is that two hollow meshing gears solidify the glue distributed on the same side of the hollow meshing gears into beads at the moment of meshing, and the meshing environment is a pure oxygen environment. The explosion beads produced by meshing are spherical, and the diameter of the ball is determined by the specifications of the meshing gear, which is 5-15mm, preferably 8-10mm (explosion beads of this size are easy to take and have a constant amount of oxygen storage). The material of the meshing gear is 316L stainless steel. Cooling water flows through the hollow of the meshing gear. The inlet temperature of the cooling water is set at 10~15℃. A pure oxygen environment is created from 99.999% oxygen. 99.999% oxygen comes from conventional cylinder gas on the market, and the manufacturer does not make special restrictions.

More specifically, the meshing speed affects the thickness of the blasting bead wall material. Generally, the thickness of the blasting bead wall material is controlled to be 0.9~1.2mm. If it is less than 0.9mm, it will affect the ability of the blasting bead to withstand the oxygen pressure wrapped in it. If it is higher than 1.2 mm will affect oxygen release efficiency.

Specifically, the secondary oxygenation is to inject oxygen again with a fine needle into the exploded beads obtained in the previous bead-making process and already containing a certain amount of pure oxygen, so that the cavity of the exploded beads contains 1800-2500Pa of oxygen. The manufacturing process is strictly in accordance with the above. The wall material of the bead blasting made by the bead process parameters has a certain elasticity, and the oxygen contained in the bead blasting cavity will not leak after the fine needle is pulled out. The material of the fine needle is 316L stainless steel. Secondary oxygenation uses 99.999% oxygen. 99.999% oxygen comes from conventional cylinder gas on the market, and the manufacturer does not make special restrictions.

Specifically, the secondary oxygenation temperature is room temperature.

Specifically, the drying is static drying, and the drying equipment involved in the static drying is a drying cage, and the manufacturer is Zhejiang Jiangnan Pharmaceutical Machinery Co., Ltd. The end point of drying is to reduce the moisture content of the bead wall material to 5-10%. At this moisture content, the shape of the soft capsule is basically finalized. If the moisture content is lower than 5%, the bead wall material will become brittle and cracks will form. If the moisture content is higher than 10%, the soft capsule will become brittle and cracks will form. The material is soft and prone to mildew.

Specifically, the drying temperature is 80-90°C, the drying environment is moderately lower than 60% RH, and the drying time is subject to reaching the drying end point.

Specifically, the equipment for preparing the CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness is an explosion bead preparation machine, which specifically includes a glue dispensing device, a bead making device, a secondary oxygenation device and a drying device; the preparation device The glue device, bead making device, secondary oxygenation device and drying device are connected in sequence from top to bottom.

Specifically, a screw vacuum pump is provided in the glue dispensing device.

Specifically, the bead-making device specifically includes a sealed bead-making structure and a cold water circulation structure, and the cold water circulation structure is arranged inside the sealed bead-making structure.

Specifically, a meshing gear is rotatably installed in the center of the sealing beading structure; wherein, the middle position of the meshing gear is a hollow structure, and the number of the meshing gears is two.

Specifically, the sealed beading structure is a pure oxygen sealed space, and a glue adding structure is fixedly installed above it.

Specifically, double-sided condensation water delivery pipes are provided on both sides below the glue adding structure, and the confluence point of the double-side condensation water delivery pipes is located in the direction of the meshing line of the two meshing gears.

Specifically, the double-sided condensed water delivery pipe specifically includes a water inlet and a water outlet, and cooling water is passed through the water inlet and the water outlet in the hollow structure.

Specifically, the secondary oxygenation device specifically includes a hexagonal turntable and a fine needle, wherein the middle position of the hexagonal turntable is a hollow structure, and the number of the hexagonal turntables is two.

Specifically, in the hexagonal turntable, the meshing line of the hexagonal turntable coincides with the meshing line of the first meshing gear, and the fine needle is located in the direction of the meshing lines of the two hexagonal turntables.

Specifically, the hexagonal turntable includes a hexagonal left turntable and a hexagonal right turntable; wherein the top corners of the hexagonal right turntable and the edges of the hexagonal left turntable move in contact with each other.

beneficial effects

The invention relates to a method for preparing CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness, broadens the application field of coenzyme Q ₁₀ , and is expected to bring new profit growth points and expected economic benefits to coenzyme Q ₁₀ related manufacturers. considerable. The bead wall material prepared according to the preparation method of the present invention contains coenzyme Q ₁₀ which can improve the blood and oxygen supply to the heart and prevent damage to myocardial cells and brain cells caused by ischemia and hypoxia. The bead cavity contains appropriately compressed oxygen. , when the explosive beads are placed in the mouth, they will release oxygen within 2 seconds, which can effectively alleviate altitude sickness. More importantly, the explosive beads prepared according to the preparation method of the present invention have a moderate diameter, are easy to carry, can effectively replace oxygen bags and ventilators, and can bring convenience to people living on plateaus to a great extent.

The instrument for preparing the CoQ ₁₀ /O ₂ explosive beads in the present invention, which can quickly alleviate altitude sickness, is a bead preparation machine. By setting up a bead making device and a secondary oxygenation device, a product that is easy to carry and can efficiently supplement oxygen can be realized. Through mass production, the popping beads produced can supplement oxygen while eating, are easy to carry, and overcome the problem of additional physical exertion.

Description of the drawings

Figure 1 is a schematic diagram of the interior of the bead-making instrument.

Figure 2 is a product diagram of the finished CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness.

Figure 3 is the overall structure diagram of the explosive bead preparation machine that can quickly alleviate altitude sickness;

Figure 4 shows the production structure diagram of the glue addition structure after adding glue in the explosive bead preparation machine that can quickly alleviate altitude sickness;

Figure 5 is a structural diagram of the bead-making device in the bead-explosion preparation machine that can quickly alleviate altitude sickness;

Figure 6 is a structural diagram of the secondary oxygenation device in the explosive bead preparation machine that can quickly alleviate altitude sickness;

In the figure, 101. Glue dispensing device; 201. Bead making device; 202. Sealed bead making structure; 203. Cold water circulation structure; 204. Meshing gear; 205. Hollow structure; 206. Glue liquid adding structure; 207. Water inlet; 208 , water outlet; 301, secondary oxygenation device; 302, hexagonal turntable; 303, fine needle; 401, drying device.

Detailed ways

Example 1

First put the purified water (90.00kg) and food-grade embedded water-soluble CoQ ₁₀ (0.10kg) into the gelling kettle (316L stainless steel, 500L, equipped with a screw vacuum pump unit including a condenser and receiving tank), start stirring, and stir The material system turns into a light yellow clear and transparent uniform liquid. Dissolve food-grade embedded water-soluble CoQ ₁₀ , add edible gelatin (100.00kg) and food-grade plasticizer (30.00kg), stir and heat to 60-65°C, and continue to keep stirring in this temperature range for 1 hour to obtain a slightly yellowish color. Thick, homogeneous liquid.

Food-grade embedded water-soluble CoQ ₁₀ is a company-made product. The manufacturer of edible gelatin is Anhui Fengyuan Gelatin Co., Ltd. The chemical component name of food-grade plasticizer is sorbitol, and the manufacturer is Zhejiang Huakang Pharmaceutical Co., Ltd.

After keeping warm and stirring, start vacuum degassing (-0.06±0.02MPa) at 60-65°C, and gradually increase the vacuum degree in the mating kettle. At first, too high a vacuum will cause the glue to boil. Vacuum degassing is completed until no obvious bubbles are released on the surface of the glue liquid and the glue liquid surface flows in a honeycomb shape. The completion of vacuum degassing is considered to be the completion of glue preparation.

The glue solution obtained after the glue preparation is completed needs to be stored at a temperature of 50 to 55°C for later use.

After the glue is mixed, the nitrogen is used to break the vacuum until the pressure in the mixing kettle reaches normal pressure. Samples are taken and sent for inspection. The moisture content of the glue liquid is 22.15%. Start bead making. The bead making process is two hollow meshing gears. The glue distributed on the same side of the hollow meshing gears solidifies into beads at the moment of meshing. The meshing environment is a pure oxygen environment. The exploded beads produced by the meshing are spherical with a ball diameter of 10mm. , the thickness of the bead wall material is 1.0mm.

The material of the meshing gear is 316L stainless steel. Cooling water flows through the hollow of the meshing gear. The inlet temperature of the cooling water is set at 10~15℃. The pure oxygen environment is created by 99.999% oxygen. 99.999% oxygen comes from conventional cylinder gas on the market. The manufacturer does not make special restrictions.

After the beads are made, secondary oxygenation begins. Secondary oxygenation is to re-inject oxygen with a fine needle into the bead-explosion cavity obtained in the previous bead-making process, which already contains a certain amount of pure oxygen, at room temperature. When the bead-explosion cavity contains 1952Pa of oxygen, the fine needle is pulled out.

The material of the fine needle is 316L stainless steel. Secondary oxygenation uses 99.999% oxygen. 99.999% oxygen comes from conventional cylinder gas on the market, and the manufacturer does not make special restrictions.

After the secondary oxygenation is completed, a drying tumbler is used to let it stand and dry at an ambient humidity of 55% RH and a drying temperature of 80 to 90°C to obtain the finished product of CoQ ₁₀ /O ₂ explosive beads (186.35kg, light in color) that can quickly alleviate altitude sickness. Yellow translucent hollow elastic sphere), the moisture content of the bead wall material is 6.82%. The product picture of the finished CoQ ₁₀ /O ₂ bead product that can quickly alleviate altitude sickness is shown in Figure 2.

The manufacturer of the drying tumbler is Zhejiang Jiangnan Pharmaceutical Machinery Co., Ltd.

The equipment for preparing the CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness is an explosion bead preparation machine, which specifically includes: a glue dispensing device 101, a bead making device 201, a secondary oxygenation device 301 and a drying device 401;

The glue dispensing device 101 includes a screw vacuum pump. A condenser and a receiving tank are fixedly installed in the screw vacuum pump. The condenser and receiving tank are used to transport and collect condensed water, thereby realizing the circulation of condensed water;

The bead-making device 201 includes a sealed bead-making structure 202, a cold water circulation structure 203 and a double-sided condensed water delivery pipe; the seal bead-making structure 202 includes a meshing gear 204 and a glue adding structure 206; the cold water circulation structure 203, including water inlet 207 and water outlet 208;

The secondary oxygenation device 301 includes a hexagonal turntable 302 and a second glue adding structure 206. The second glue adding structure 206 includes a fine needle 303; the hexagonal turntable 302 includes a hexagonal Left turntable and hexagonal right turntable.

In one embodiment, the connection mode of each structure in the bead-explosion preparation machine that can quickly alleviate altitude sickness is: the glue dispensing device 101 is connected to the bead-making device 201, and the bead-making device 201 is connected to the secondary oxygenation device. The device 301 is connected, and the secondary oxygenation device 301 is connected with the drying device 401; a meshing gear 204 is installed in the center of the sealed bead-making structure 202, and the middle position of the meshing gear 204 is a hollow structure 205. The meshing gear The number 204 is two. The sealing beading structure 202 and the cold water circulation structure 203 are two independent structures that are not connected. A glue adding structure 206 is fixedly installed above the sealing beading structure 202, and bilateral condensation water delivery pipes are provided on both sides below the glue adding structure 206. The confluence of the two sides of the condensation water delivery pipes is located at the two meshing points. In the direction of the gear 204 meshing line; the double-sided condensed water delivery pipe passes cooling water in the hollow structure 205 through the water inlet 207 and the water outlet 208. In the secondary oxygenation device 301, the hexagonal The middle position of the turntable 302 is a hollow structure 205, and the number of the hexagonal turntables 302 is two. In the hexagonal turntable 302, the meshing line of the hexagonal turntable 302 coincides with the meshing line of the first meshing gear 204. The fine needle 303 is located in the direction of the meshing line of the two hexagonal rotating disks 302.

In one embodiment, the working principle of the blasting bead preparation machine that can quickly alleviate altitude sickness is as follows: performing a glue dispensing operation of CoQ ₁₀ /O ₂ blasting bead wall material rubber in the glue dispensing device 101. Finally, vacuum degassing is performed in the glue dispensing device 101. After vacuum degassing, the glue liquid is transferred to the glue liquid adding structure 206 of the bead making device 201. In the sealed bead making structure 202, through two meshing gears 204 The rotating meshing motion instantly solidifies the glue into beads at the position of the meshing line. At the same time, since the middle position of the meshing gear 204 is a hollow structure 205, the hollow structure 205 cooperates with the water inlet 207 and the water outlet 208 in the cold water circulation structure 203 to cool down and solidify the glue through cooling water circulation. While being solidified into beads, since the sealed beading structure 202 is a pure oxygen sealed space, the oxygen in the sealed beading structure 202 can be sealed into the interior of the bead-exploding film, and at the same time, the fixedly installed glue adding structure 206 described in this patent It is a negative pressure push rod structure with a specified volume of glue liquid sealed inside. When the oxygen in the sealed bead making structure 202 is consumed and negative pressure is generated, the push rod in the glue liquid adding structure 206 will automatically push downwards. , and perform glue replenishment operations. The exploded beads solidified into beads are transferred to the secondary oxygenation device 301. In the secondary oxygenation device 301, oxygen is replenished into the exploded beads through the fine needle 303. Since the exploded bead wall material has a certain elasticity, when the fine needle 303 After 303 slightly pulls out the bead blasting chamber, the oxygen inside the bead blasting chamber will not leak. At the same time, the exploded beads after supplementing with oxygen are transported through two hexagonal turntables 302 and transported to the drying device 401, and the drying cage in the drying device 401 is used to perform the standing drying process of the exploded beads.

Claims (10)

1. A method for preparing CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness, which is characterized in that it includes the following steps: four steps of glue preparation, bead making, secondary oxygenation and drying; The rubber is a wall material rubber equipped with explosive beads. The main ingredients are edible gelatin, food-grade plasticizer, food-grade embedded water-soluble CoQ ₁₀ and purified water; The glue preparation is completed in the glue preparation kettle. First, the food-grade embedded water-soluble CoQ ₁₀ is completely dissolved with purified water to obtain CoQ ₁₀ liquid, and then edible gelatin and food-grade plasticizer are added to the CoQ ₁₀ liquid at one time; The bead making process is that two hollow meshing gears solidify the glue distributed on the same side of the hollow meshing gear into beads at the moment of meshing, and the meshing environment is a pure oxygen environment; The secondary oxygenation is to inject oxygen again with a fine needle into the exploded beads obtained in the previous bead-making process and already containing a certain amount of pure oxygen; The drying is static drying, and the drying equipment involved in static drying is a drying cage. 2. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the chemical component name of the food-grade plasticizer is sorbitol. 3. The preparation method of CoQ ₁₀ /O ₂ popping beads that can quickly alleviate altitude sickness according to claim 2, characterized in that the dosage of sorbitol is 0.2 to 0.7 mass times that of edible gelatin. 4. The preparation method of CoQ ₁₀ /O ₂ popping beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the dosage of sorbitol is 0.2 to 0.7 mass times that of edible gelatin. 5. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the food-grade embedded water-soluble CoQ ₁₀ is ready-to-eat-grade embedded water-soluble CoQ ₁₀ . , its dosage is 0.001 mass times of edible gelatin. 6. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the amount of purified water is 0.8-1.2 mass times of food grade gelatin. 7. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the glue solution obtained after the glue preparation is completed needs to be stored at a temperature of 50 to 55°C for later use. 8. The preparation method of CoQ ₁₀ /O ₂ exploding beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the thickness of the exploding bead wall material is 0.9 to 1.2 mm. 9. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the secondary oxygenation temperature is room temperature. 10. The preparation method of CoQ ₁₀ /O ₂ explosive beads that can quickly alleviate altitude sickness according to claim 1, characterized in that the drying temperature is 80-90°C.