CN116712670B - Electronic treatment system and electronic device, synchronization method and storage medium contained therein - Google Patents

Abstract

The invention provides an electronic therapy system, an electronic device, a synchronization method and a storage medium contained in the electronic therapy system, and relates to the technical field of electronic medical treatment. The electronic therapy system includes an external electronic device and at least one internal electronic device, each of the at least one internal electronic device being electrically connected to at least one electrode disposed within a patient, and the synchronization method includes: acquiring the time stamp offset of each electronic device; the time synchronization of the electronic devices is realized according to the respective time stamp offset of the electronic devices. The time stamp offset of different electronic devices is adopted in the time synchronization process, so that errors caused by time stamp differences in the traditional synchronization mode can be solved, the time synchronization precision can be improved, the requirement of medical system data processing on time precision can be met, the accuracy of clinical judgment reference can be ensured, and the collaborative work of acquisition, stimulation, drug administration and the like of each electronic device can be realized.

Description

Electronic treatment system and electronic device, synchronization method and storage medium contained therein

This application is a divisional application of the Chinese invention patent application with application number 202010014295.3 filed on January 7, 2020.

Technical Field

The present invention relates to the field of electronic medical technology, and in particular to an electronic treatment system and electronic devices contained therein, a time synchronization method between the electronic devices, and a computer-readable storage medium.

Background technique

Various types of medical devices implanted in the human body are buried in the bones or cavity tissues of various parts of the human body. They include collectors that can collect bioelectricity from corresponding parts of the human body and stimulators that can apply stimulation of appropriate intensity to various parts of the human body.

In recent years, the complexity of electronic systems implanted in the body has been increasing day by day, and the requirements for the coordinated operation of multiple implanted electronic devices or implanted electronic devices in the body and external electronic devices have become increasingly higher.

Unlike external electronic devices, implantable electronic devices in the body generally use wireless methods for control and data transmission. Traditional implantable electronic devices in the body often work independently, and the control signal or acquisition signal of each implantable electronic device in the body cannot be accurately synchronized with the wireless signals of other implantable electronic devices in the body or external electronic devices. In order to improve the diagnostic accuracy and work efficiency of diseases, doctors often need to more accurately grasp the activity status of different treatment parts of the patient in the same time period (point) and the corresponding physiological electrical signal changes, which requires synchronous comparison and analysis of the collaborative work data of multiple electronic devices.

In this scenario, it is necessary to collect, stimulate, and administer drugs to multiple parts simultaneously. For example, the judgment of physiological electrical signals needs to be based on the signals from different parts; stimulation and drug administration also need to be evaluated and processed based on the overall physiological condition.

However, the traditional method is to record or clear the timestamps of multiple electronic devices separately when they are started, and then synchronize data based on the timestamps. However, due to differences in a series of circuit characteristics such as the working clock/frequency of different electronic devices, the timestamp differences of signals of multiple devices will gradually increase when working together, resulting in a decrease in the accuracy of time synchronization, which cannot meet the accuracy requirements of time synchronization in the above scenarios.

Therefore, there is an urgent need in the art for a time synchronization method to achieve time synchronization of different electronic devices in an electronic treatment system.

Summary of the invention

In order to solve the above-mentioned technical problems existing in the above-mentioned prior art, the embodiment of the present invention provides an electronic treatment system and the electronic devices contained therein, and a time synchronization method between the electronic devices, so as to realize the synchronization of multiple electronic devices and realize the coordinated collection, stimulation, drug administration and other tasks of each electronic device.

According to a first aspect of the present invention, an embodiment of the present invention provides an electronic treatment system, comprising:

At least one in-vivo electronic device, which is suitable for being arranged in the body of a patient, each of the at least one in-vivo electronic device is electrically connected to at least one electrode arranged in the body of the patient, and collects data of physiological electrical signals of the patient or sends stimulation signals to the patient through the electrode;

an external electronic device adapted to be disposed outside the patient's body and wirelessly connected to the at least one internal electronic device; and

A main control device, which is suitable for being arranged outside the patient's body and connected to the external electronic device by wire or wirelessly, and is used to control and process data of the internal electronic device and the external electronic device;

Among them, the main control device controls and processes the data of the internal electronic device and the external electronic device, including: realizing time synchronization of the various electronic devices according to the timestamp offset of each electronic device in the at least one internal electronic device and the external electronic device.

In one embodiment of the present invention, the timing is based on the time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device to achieve time synchronization of the respective electronic devices.

In one embodiment of the present invention, the main control device realizes time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device, including:

Selecting a time axis of any one of the electronic devices as a baseline time;

Taking the baseline time as the reference and adding the difference between the timestamp offset of each other electronic device in the electronic devices and the timestamp offset of the electronic device corresponding to the baseline time (i.e. the time offset of other electronic devices relative to the electronic device serving as the baseline), the actual time of collecting data or sending stimulation by the other electronic devices is obtained.

In another embodiment of the present invention, the main control device realizes time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device, including:

The main control device sends a synchronization signal to each of the electronic devices;

Each electronic device clears its own timestamp offset after receiving the synchronization signal, and the timestamp offset after clearing starts to increase synchronously with the running time;

The main control device receives the timestamp offset of each electronic device;

The main control device uses the time axis of any one of the electronic devices as a time baseline, and aligns the time of collecting data or sending stimulation according to the respective timestamp offsets of the electronic devices in the body.

The main control device may send a synchronization signal to each electronic device at a predetermined time interval. Optionally, the predetermined time interval may be 10 seconds to 200 seconds.

In other embodiments of the present invention, the main control device controlling and processing the data of the internal electronic device and the external electronic device may also include: storing and/or displaying the time-synchronized collected data.

In some embodiments of the present invention, the main control device controls and processes data of the internal electronic device and the external electronic device, and further includes:

generating a stimulation command or selecting a predefined stimulation command according to the collected data;

The stimulation command is sent to one or more of the at least one in vivo electronic device and the in vitro electronic device.

Wherein, the in-vivo electronic device that receives the stimulation command can generate a stimulation signal according to the stimulation command, and send the stimulation signal to the corresponding electrode. Optionally or additionally, the in-vivo electronic device that receives the stimulation command can send an in-vitro stimulation to the patient at a synchronized time. Wherein, the in-vitro stimulation can include auditory stimulation, visual stimulation, tactile stimulation, etc.

In an optional embodiment of the present invention, the main control device and the external electronic device can be integrated into a single device. In other words, the above-mentioned processing of the main control device and the external electronic device can be uniformly performed by a single computing device.

According to a second aspect of the present invention, an embodiment of the present invention provides a control device for use in an electronic treatment system, comprising:

a communication interface that communicates with at least one internal electronic device implanted in the patient through the external electronic device connected thereto;

a memory having computer instructions stored thereon;

A processor is configured to execute the computer instructions to perform the following operations: achieving time synchronization of each electronic device according to a time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device.

In one embodiment of the present invention, the processor executes the computer instructions to achieve time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device, including:

Select the time axis of any one of the electronic devices as the baseline time; take the baseline time as the reference and add the difference between the timestamp offset of each of the other electronic devices and the timestamp offset of the electronic device corresponding to the baseline time to obtain the actual time of collecting data or sending stimulation of the other electronic devices.

In another embodiment of the present invention, the processor executes the computer instructions to achieve time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device, including:

The processor executes the computer instructions to perform the following operations:

Sending a synchronization signal to each of the electronic devices, wherein each of the electronic devices clears its own timestamp offset after receiving the synchronization signal, and the timestamp offset after clearing starts to increase synchronously with the running time;

Receiving a timestamp offset of each electronic device;

The time axis of any one of the electronic devices is used as the time baseline, and the time of collecting data or sending stimulation is aligned according to the timestamp offset of each in-vivo electronic device.

In some embodiments of the present invention, the processor executes the computer instructions to perform the operation of implementing time synchronization of the at least one in vivo electronic device and the in vitro electronic device according to the timestamp offset of each electronic device at a predetermined time interval. For example, the predetermined time interval may include 10 seconds to 200 seconds.

In some embodiments of the present invention, the processor executes the computer instructions to store the synchronized collected data in the memory or other storage device. Optionally, the control device also includes a display, wherein the processor executes the computer instructions to display the synchronized collected data through the display.

In other embodiments of the present invention, the processor executes the computer instructions to perform the following operations:

Generate a stimulation command or select a predefined stimulation command according to the collected data;

The stimulation command is sent to one or more of the at least one in vivo electronic device and the in vitro electronic device.

According to a third aspect of the present invention, an embodiment of the present invention provides an in-vivo electronic device suitable for implantation in a patient's body, comprising:

a communication interface that communicates with the control device via an external electronic device wirelessly connected thereto or communicates with the control device via a wireless connection;

a memory having computer instructions stored thereon;

A processor is used to execute the computer instructions to send the collected data and timestamp offset obtained by collecting the physiological conditions in the patient's body through the electrodes to the control device, so that the control device can synchronize time with other electronic devices according to the timestamp offset, for example, the control device can synchronize the collected data from each in-body electronic device with the timestamp offset of other in-body electronic devices according to the timestamp offset.

In one embodiment of the present invention, the processor executes the computer instructions to perform the following operations:

The timestamp offset of the controller is cleared according to the synchronization signal received from the controller, and the timestamp offset after clearing starts to increase synchronously with the running time;

The collected data and the timestamp offset collected by the electrodes are sent to the control device through the communication interface.

In another embodiment of the present invention, the processor executes the computer instruction and further performs the following operations:

A stimulation signal is generated according to the stimulation command from the control device received by the communication interface, and the stimulation signal is sent to the corresponding electrode.

According to a fourth aspect of the present invention, an embodiment of the present invention provides an extracorporeal electronic device, comprising:

a communication interface that communicates with the in-vivo electronic device via a wireless connection and communicates with the control device via a wireless connection or a wired connection;

a memory having computer instructions stored thereon;

A processor is used to execute the computer instructions to send a timestamp offset to the control device, so that the control device can achieve time synchronization according to the timestamp offset and the timestamp offset of the in-vivo electronic device.

In one embodiment of the present invention, the processor executes the computer instructions to perform the following operations:

The timestamp offset of the controller is cleared according to the synchronization signal received from the controller, and the timestamp offset after clearing starts to increase synchronously with the running time;

The time stamp offset of the device itself and the time stamp offset from the in-vivo electronic device are sent to the control device through the communication interface.

In one embodiment of the present invention, the processor executes the computer instructions to perform the following operations:

Sending external stimulation to the patient according to the stimulation command from the control device received by the communication interface. Optionally, the external stimulation includes auditory stimulation, visual stimulation, tactile stimulation, etc.

According to a fifth aspect of the present invention, an embodiment of the present invention provides a method for time synchronization of an electronic treatment system, wherein the electronic treatment system comprises an external electronic device and at least one internal electronic device, each of the at least one internal electronic device is electrically connected to at least one electrode arranged in a patient's body, and the method comprises:

Obtaining a timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

Time synchronization of each electronic device is achieved according to the respective timestamp offset of each electronic device.

In one embodiment of the present invention, the step of implementing time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device comprises:

Selecting a time axis of any one of the electronic devices as a baseline time;

The actual time of collecting data or sending stimulation by the other electronic devices is obtained by taking the baseline time as a reference and adding the difference between the timestamp offset of each other electronic device in the electronic devices and the timestamp offset of the electronic device corresponding to the baseline time.

In one embodiment of the present invention, the method further comprises:

Before acquiring the timestamp offset of each electronic device, a synchronization signal is sent to each electronic device to clear the timestamp offset of each electronic device, and the timestamp offset after clearing starts to increase synchronously with the running time.

Among them, realizing the time synchronization of the electronic devices according to the timestamp offset of each electronic device in the at least one in vivo electronic device and the in vitro electronic device may include: taking the time axis of any one of the electronic devices as the time baseline, and aligning the time of collecting data or sending stimulation according to the timestamp offset of each in vivo electronic device.

Optionally, the steps of the method may be performed at a predetermined time interval, wherein the predetermined time interval may include 10 seconds to 200 seconds.

According to the sixth aspect of the present invention, an embodiment of the present invention provides a computer-readable storage medium, on which computer instructions are stored. When the computer instructions are executed by a processor, the methods, operations, processes or steps described in any one of the above embodiments are implemented.

The implementation of the present invention can achieve the following beneficial effects:

According to various embodiments of the present invention, time synchronization between electronic devices is achieved through the timestamp offset of each electronic device. The timestamp changes, i.e., offsets, of different electronic devices are taken into account during the synchronization process, thereby resolving errors caused by timestamp differences in traditional synchronization methods and improving the accuracy of time synchronization. In particular, it can meet the requirements for time accuracy in data processing in the electronic medical field, ensure the accuracy of clinical judgment references, and realize the coordinated work of various electronic devices in collection, stimulation, and drug administration.

By synchronizing the time between the in-vivo electronic device and the in-vivo electronic device, the time of issuing the in-vivo stimulation and the time of collecting the data of the in-vivo physiological electrical signal can be synchronized.

By using the time synchronization technology of the present invention, multiple in-body electronic devices can be implanted in different parts of the body to collect/stimulate different parts at the same time. Thus, the following technical problems existing in the existing method of using one implanted device to branch out the connection line for collecting/stimulating different parts at the same time can be avoided:

1) The connecting wire needs to be fixed inside the skull, which increases the scope of surgical trauma;

2) The signal is easily disturbed during the transmission of the connecting line, which affects the accuracy of the analysis;

3) Implantable electronic devices are limited by batteries and power. Generally, an implantable device only supports two external connection lines. At the same time, in this case, the power that can be supported on each connection line for data acquisition and stimulation or drug administration is 1/2 of the maximum power;

4) If the two collection, stimulation or drug delivery sites are too far apart, they cannot be achieved with one implanted device.

To sum up, in the electronic treatment system adopting the time synchronization method of the present invention, in addition to solving the problem of decreased time synchronization accuracy in traditional synchronization methods, different in-vivo electronic devices can also be implanted in different parts of the body, thereby further solving the above four technical problems caused by different connections branching out from an existing implanted device, and realizing simultaneous data collection and stimulation of different parts.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a block diagram of an electronic therapeutic system according to an exemplary embodiment of the present invention.

FIG. 2 is a flow chart of time synchronization in the system shown in FIG. 1 .

FIG. 3 is a block diagram of an electronic treatment system according to another embodiment of the present invention.

FIG. 4 is a flow chart of a method for time synchronization of an electronic treatment system according to an exemplary embodiment of the present invention.

FIG. 5 is a flow chart of a method for time synchronization of an electronic treatment system according to another exemplary embodiment of the present invention.

FIG. 6 is a block diagram of a control device used in an electronic treatment system according to an exemplary embodiment of the present invention.

7 is a block diagram of an in vivo electronic device suitable for implantation in a patient according to an exemplary embodiment of the present invention.

8 is a block diagram of an extracorporeal electronic device according to an exemplary embodiment of the present invention.

Detailed ways

The various aspects of the present invention are described in detail below in conjunction with the accompanying drawings and specific embodiments. Among them, well-known modules, units and their connections, links, communications or operations are not shown or described in detail. In addition, the described features, architectures or functions can be combined in any way in one or more embodiments. It should be understood by those skilled in the art that the various embodiments described below are only used for illustration and are not intended to limit the scope of protection of the present invention. It can also be easily understood that the modules or units or processing methods in each embodiment described herein and shown in the accompanying drawings can be combined and designed in various different configurations.

FIG1 is a block diagram of an electronic treatment system according to an exemplary embodiment of the present invention. In an exemplary embodiment of the present invention, the electronic treatment system may include a main control device 100, an external electronic device 200, and multiple internal electronic devices (including a first internal electronic device 301 and a second internal electronic device 302). The multiple internal electronic devices are respectively connected to electrodes and arranged at different parts of the patient's body to facilitate simultaneous acquisition or stimulation of different parts. In this embodiment, the first internal electronic device 301 is electrically connected to the electrode 401, and the second internal electronic device 302 is electrically connected to the electrode 402. In an optional embodiment, the number of internal electronic devices may be more than 2, or only one; and one internal electronic device may be connected to two or more electrodes. In this embodiment, the first internal electronic device 301 collects data of physiological electrical signals of one part through the electrode 401, and the second internal electronic device 302 collects data of physiological electrical signals of another part through the electrode 402. Alternatively, the first internal electronic device 301 applies stimulation (e.g., pulse) to the one part through the electrode 401, and the second internal electronic device 302 applies stimulation (e.g., pulse) to the other part through the electrode 402.

In this embodiment, as shown in FIG. 2 , the external electronic device 200 is arranged outside the patient's body, connected to the first internal electronic device 301 and the second internal electronic device 302 by wireless communication, and connected to the main control device 100 by wired communication. Optionally, the external electronic device 200 and the main control device 100 can also be connected by wireless communication. The external electronic device 200 sends the collected data uploaded by the first internal electronic device 301 and the second internal electronic device 302 to the main control device 100. In addition, the external electronic device 200 can transmit the stimulation command sent by the main control device 100 to the first internal electronic device 301 and the second internal electronic device 302, so that the first internal electronic device 301 and the second internal electronic device 302 generate stimulation signals according to the stimulation command. In one embodiment of the present invention, the external electronic device 200 can directly send stimulation to the patient in vitro according to the control of the main control device 100, for example, play sound, image, etc. In some embodiments of the present invention, the main control device 100 can generate stimulation commands according to the collected data. In other embodiments of the present invention, the main control device 100 may also select a predefined stimulation command, for example, to control an in-vivo electronic device or an out-vivo electronic device to send stimulation according to a predefined stimulation pattern.

In this embodiment, the main control device 100 is used to control and process the data of the in-vivo electronic devices 301, 302 and the external electronic device 200, including: realizing the time synchronization of the electronic devices according to the timestamp offset of each electronic device in the in-vivo electronic devices 301, 302 and the external electronic device 200. For example, the time of collecting data of the first in-vivo electronic device 301 and the second in-vivo electronic device 302 is synchronized, and the time of sending stimulation of the external electronic device 200 is synchronized with the time of collecting data of the in-vivo electronic device. In an exemplary embodiment, the main control device 100 can perform the time synchronization operation regularly, so as to control the time synchronization of the system within a predetermined accuracy range. In one embodiment of the present invention, the time synchronization includes: selecting the time axis of any one of the electronic devices as the baseline time; taking the baseline time as the reference and adding the difference between the timestamp offset of each of the other electronic devices in the electronic devices and the timestamp offset of the electronic device corresponding to the baseline time to obtain the actual time of collecting data or sending stimulation of the other electronic devices.

The time synchronization method according to an embodiment of the present invention is described in detail below with reference to FIG. 2 .

When not synchronized

In comparison, when the time synchronization of the present invention is not performed, the first internal electronic device 301, the second internal electronic device 302 and the external electronic device 200 communicate with the main control device 100 respectively and independently, and the communication data includes the timestamp of each electronic device itself, and the timestamp increases automatically as the electronic device runs.

The main control device 100 processes data according to the timestamp of each electronic device. Due to the deviation of the performance of each crystal oscillator, the timestamp increment of each electronic device is different. Therefore, there is a synchronization error when processing data according to the timestamp, and the error increases with time.

When syncing

The main control device 100 sets the synchronization frequency according to the system's estimated error and application needs, and sends it to the external electronic device 200, the first internal electronic device 301, and the second internal electronic device 302, that is, initiates synchronization at a predetermined time interval. For example: when used for ERP analysis, or when the lead signal generation sequence and phase difference analysis are performed, the error accuracy is required to be 1ms, and a shorter synchronization period can be set; when used for signal spectrum analysis, the error accuracy can be controlled within 50ms, and a longer synchronization period can be set to reduce power consumption. In one embodiment of the present invention, the clock error of the electronic system generally comes from the crystal oscillator. When a crystal oscillator with a precision of 5ppm is selected, the error of the electronic device is within 5us per second, so the synchronization period (predetermined time interval) is set within 200s and should meet the 1ms time accuracy requirement. When a crystal oscillator with a precision of 20ppm is selected, the error of the electronic device is within 20us per second, so the synchronization accuracy is set within 50s and should meet the 1ms time accuracy requirement. Generally, the range of the predetermined time interval can be 10 seconds to 200 seconds.

After the synchronization cycle is set, the synchronization process is as follows:

S010: The main control device 100 periodically sends a synchronization signal to the external electronic device 200, the first internal electronic device 301, and the second internal electronic device 302.

S020: After receiving the synchronization signal from the main control device 100, each of the above-mentioned electronic devices clears its own timestamp offset, and the timestamp offset after being cleared begins to increase synchronously with the running time of the electronic device.

S030: The main control device 100 receives the respective timestamp offsets sent by each electronic device, takes the time axis of a certain electronic device in the system as the baseline time, and realigns the time of collecting data or sending stimulation according to the timestamp offsets in the data of each electronic device.

In one embodiment of the present invention, the actual time of each electronic device relative to the baseline time may be determined according to the following formula, namely:

The actual time of the electronic device = baseline time + (timestamp offset of the electronic device - timestamp offset of the electronic device corresponding to the baseline time)

For example, the timestamp offset of the first in vivo electronic device 301 is Δt1, the timestamp offset of the second in vivo electronic device 302 is Δt2, and the timestamp offset of the external electronic device 200 is Δt3. Taking the time axis t of the first in vivo electronic device 301 as the time baseline, the actual time of the second in vivo electronic device 302 is t+(Δt2-Δt1), and the actual time of the external electronic device 200 is t+(Δt3-Δt1).

Then, the respective acquired data and/or stimulations are aligned based on the actual time of the respective electronic devices.

During operation, the entire system repeats the synchronization process S010-S030 according to the set synchronization cycle or predetermined time interval to ensure that the time error of the data of each electronic device in the system is within 1 millisecond during the 24-hour recording process.

In this exemplary embodiment, the synchronization method of the present invention is described by taking two in-vivo electronic devices as an example. In an optional embodiment, the electronic treatment system may include more than three in-vivo electronic devices, each of which may be connected to more than two electrodes. In other embodiments, the electronic treatment system may also include one in-vivo electronic device, which may be connected to one or more than two electrodes.

Figure 3 shows an electronic treatment system according to another embodiment of the present invention. In this embodiment, in addition to the main control device 100 and the external electronic device 200 arranged outside the body as described in the above embodiment, the electronic treatment system also includes an internal electronic device 300 arranged inside the body. The internal electronic device 300 is connected to two electrodes 401 and 402 arranged at two different parts through a connecting wire. Of course, in an optional embodiment, the internal electronic device 300 can be connected to one electrode or more than three electrodes. In this embodiment, the internal electronic device 300 is wirelessly connected to the external electronic device 200, and the external electronic device 200 is wired to the main control device 100.

In this embodiment, when the synchronization function is started, the main control device 100 sends a synchronization signal to the external electronic device 200 and the internal electronic device 300 at a fixed time. After receiving the synchronization signal from the main control device 100, the external electronic device 200 and the internal electronic device 300 clear their own timestamp offsets, and the timestamp offsets after clearing begin to increase synchronously with the corresponding electronic device running time. The main control device 100 receives the respective timestamp offsets sent by each electronic device, and can use the time axis of the external electronic device 200 as the baseline time, and calculate the time offset of the internal electronic device 300 relative to the external electronic device 200 according to the received timestamp offset of the internal electronic device 300 and the timestamp offset of the external electronic device 200, and obtain the actual time of the internal electronic device 300 relative to the baseline time by adding the calculated time offset to the baseline time, thereby synchronizing the time of the internal electronic device 300 to collect data with the time of the external electronic device 200 to send stimulation. In this embodiment, the stimulation sent to the human body by the external electronic device 200 may include visual stimulation (such as images), auditory stimulation (such as sound) or other stimulation (such as bone conduction).

It can be seen from the above implementation that the present invention extracts the time stamp offset of each electronic device in the system, and aligns the execution time of each electronic device (including collecting data and sending stimulation) through the time stamp offset. Compared with the existing method of aligning time only based on the time stamp, it avoids the time deviation caused by the self-increment of the timestamp, improves the synchronization accuracy, and can especially meet the time synchronization requirements of the electronic medical system for data processing.

The electronic treatment system provided by the present invention is described in detail above. The synchronization method provided by the present invention is described in detail below.

FIG4 is a flow chart of a method for time synchronization of an electronic therapy system according to an exemplary embodiment of the present invention. As described above, the electronic therapy system may include an external electronic device and at least one internal electronic device, each of the at least one internal electronic device being electrically connected to at least one electrode disposed in a patient's body, and the method may include:

S100: Acquire a timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

S200: Time synchronization of each electronic device is achieved according to the timestamp offset of each electronic device. Optionally, in processing S200, the time axis of any one of the electronic devices is selected as the baseline time; the baseline time is used as a reference to add the difference between the timestamp offset of each of the other electronic devices and the timestamp offset of the electronic device corresponding to the baseline time to obtain the actual time of collecting data or sending stimulation of the other electronic devices.

FIG5 is a flow chart of a method for time synchronization of an electronic treatment system according to another exemplary embodiment of the present invention. In this embodiment, the method may include:

S501: Sending a synchronization signal to each electronic device to reset the timestamp offset of each electronic device, and the timestamp offset after reset starts to increase synchronously with the running time;

S502: Obtaining a timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

S503: Selecting a time axis of any one of the electronic devices as a time baseline;

S504: Align the time of collecting data or sending stimulation according to the timestamp offset of each in-vivo electronic device.

In one embodiment of the present invention, in processing S504, the time offset of each electronic device relative to the electronic device corresponding to the baseline time is determined based on the received timestamp offset, and the time baseline is aligned based on the time offset of each electronic device, thereby achieving time synchronization for each electronic device to collect data or send stimulation.

In other embodiments of the present invention, in process S504, the actual time of each electronic device relative to the baseline time may be determined according to the following formula, namely:

The actual time of the electronic device = baseline time + (timestamp offset of the electronic device - timestamp offset of the electronic device corresponding to the baseline time)

For example, the timestamp offset of the first in vivo electronic device is Δt1, the timestamp offset of the second in vivo electronic device is Δt2, and the timestamp offset of the external electronic device is Δt3. Taking the time axis t of the first in vivo electronic device as the time baseline, the actual time of the second in vivo electronic device is t+(Δt2-Δt1), and the actual time of the external electronic device is t+(Δt3-Δt1).

Then, the respective acquired data and/or stimulations are aligned based on the actual time of the respective electronic devices.

In an optional embodiment of the present invention, the method can be performed at a predetermined time interval, and the accuracy of time synchronization can be controlled within a predetermined range. For example, the predetermined time interval can include 10 seconds to 200 seconds. Specifically, the clock error of the electronic system generally comes from the crystal oscillator. When a crystal oscillator with a precision of 5ppm is selected, the error of the electronic device per second is within 5us, so the synchronization period (predetermined time interval) is set within 200s and should meet the 1ms time accuracy requirement. When a crystal oscillator with a precision of 20ppm is selected, the error of the electronic device per second is within 20us, so the synchronization accuracy is set within 50s and should meet the 1ms time accuracy requirement.

It can be seen from the above that the synchronization method of the present invention can control the time accuracy requirement to 1 ms, which is sufficient to meet the requirements of data processing in the field of electronic therapy.

Through the description of the above implementation methods, those skilled in the art can clearly understand that the present invention can be implemented by combining software with a hardware platform. Based on such an understanding, all or part of the contribution of the technical solution of the present invention to the background technology can be embodied in the form of a software product, which can be stored in a storage medium such as ROM/RAM, a magnetic disk, an optical disk, etc., including several instructions for enabling a computer device (which can be a personal computer, a server, or a network device, etc.) to execute the methods described in various embodiments of the present invention or certain parts of the embodiments.

Accordingly, a computer-readable storage medium according to an embodiment of the present invention stores computer instructions thereon, and when the computer instructions are executed by a processor, the methods, processes, operations, etc. described in any of the above embodiments are implemented.

In addition, FIG6 shows a control device used in an electronic treatment system according to an exemplary embodiment of the present invention. As shown in FIG6 , the control device includes:

a communication interface 601, which communicates with at least one internal electronic device implanted in the patient through an external electronic device connected thereto;

Memory 602, on which computer instructions are stored;

The processor 603 is configured to execute the computer instructions to perform the following operation: realizing time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device.

In one embodiment of the present invention, the processor 603 executes the computer instructions to achieve time synchronization of the electronic devices according to the timestamp offset of each electronic device in the at least one internal electronic device and the external electronic device, including: selecting the time axis of any one of the electronic devices as the baseline time; taking the baseline time as the reference and adding the difference between the timestamp offset of each of the other electronic devices in the electronic devices and the timestamp offset of the electronic device corresponding to the baseline time to obtain the actual time of collecting data or sending stimulation of the other electronic devices.

In another embodiment of the present invention, the processor 603 executes the computer instructions to achieve time synchronization of each electronic device according to the timestamp offset of each electronic device in the at least one in vivo electronic device and the in vitro electronic device, including: sending a synchronization signal to each electronic device; each electronic device clears its own timestamp offset after receiving the synchronization signal, and the timestamp offset after clearing starts to increase synchronously with the running time; receiving the timestamp offset of each electronic device; taking the time axis of any one of the electronic devices as the time baseline, and aligning the time of collecting data or sending stimulation according to the timestamp offset of each in vivo electronic device.

In other embodiments of the present invention, the processor 603 executes the computer instructions to perform the operation of implementing time synchronization of the at least one in-vivo electronic device and the in-vitro electronic device according to the timestamp offset of each electronic device at a predetermined time interval, wherein the predetermined time interval may include 10 seconds to 200 seconds.

In an optional embodiment of the present invention, the processor 603 executes the computer instructions to store the synchronized collected data in the memory 602. Of course, the data can also be stored in other storage devices. In a further embodiment of the present invention, the main control device also includes a display (not shown), wherein the processor 603 executes the computer instructions to display the synchronized collected data through the display.

In a further embodiment of the present invention, the processor 603 executes the computer instructions to further perform the following operations: generating a stimulation command or selecting a predefined stimulation command based on the acquired data; sending the stimulation command to one or more of the at least one in vivo electronic device and the in vitro electronic device.

FIG7 shows an in-vivo electronic device suitable for implantation in a patient according to an exemplary embodiment of the present invention. In addition to having the common features of devices implantable in patients in the art, the in-vivo electronic device, as shown in FIG7, also includes:

A communication interface 701, which communicates with the control device via an external electronic device wirelessly connected thereto;

Memory 702, on which computer instructions are stored;

The processor 703 is used to execute the computer instructions to send the collected data and timestamp offset obtained by collecting the physiological conditions of the patient's body through the electrodes to the control device through the communication interface 701, so that the control device can synchronize time with other electronic devices according to the timestamp offset as described above.

In this embodiment, the processor 703 executes the computer instructions to perform the following operations: clearing its own timestamp offset according to the synchronization signal received from the control device, and the timestamp offset after clearing begins to increase synchronously with the running time; sending the collected data and timestamp offset collected by the electrodes to the control device through the communication interface.

In an optional embodiment of the present invention, the processor 703 executes the computer instructions to perform the following operations: generate a stimulation signal (eg, a pulse) according to a stimulation command from the control device received by the communication interface 701, and send the stimulation signal to the corresponding electrode.

FIG. 8 shows an extracorporeal electronic device according to an exemplary embodiment of the present invention.

As shown in FIG8 , the external electronic device may include:

A communication interface 801, which is connected to the in-vivo electronic device via a wireless connection and communicates with the control device via a wireless connection or a wired connection;

Memory 802, on which computer instructions are stored;

The processor 803 is configured to execute the computer instructions to send the timestamp offset to the control device, so that the control device can synchronize time with the timestamp offset of the in-vivo electronic device according to the timestamp offset as described above.

In this embodiment, the processor 803 executes the computer instructions to perform the following operations: clearing its own timestamp offset according to the synchronization signal received from the control device, and the timestamp offset after clearing begins to increase synchronously with the running time; sending its own timestamp offset and the timestamp offset from the in vivo electronic device to the control device through the communication interface 801.

In an optional embodiment of the present invention, the extracorporeal electronic device also includes a stimulation generator (not shown), and the processor 803 executes the computer instructions to perform the following operations: controlling the stimulation generator to send extracorporeal stimulation to the patient according to the stimulation command from the control device received by the communication interface 801. For example, the extracorporeal stimulation may include auditory stimulation, visual stimulation, and tactile stimulation.

In summary, through various embodiments of the present invention, the coordinated operation of multiple in-vivo electronic devices can be achieved. Due to the use of multiple in-vivo electronic devices, the additional surgical trauma caused by the connecting wires is reduced, the signal interference is reduced, and the applications of synchronous signal acquisition, stimulation, and drug administration at a longer distance are achieved. It is possible to achieve precise synchronization of multiple in-vivo electronic devices or an in-vivo electronic device with an external electronic device, and the time error of multiple electronic devices can be controlled to ±1 millisecond within 24 hours.

The above detailed description of various aspects of the present invention is made through various embodiments. Those skilled in the art should understand that what is disclosed above is only the embodiment of the present invention, and it certainly cannot be used to limit the scope of the rights of the present invention. Equivalent changes made according to the embodiment of the present invention still fall within the scope covered by the claims of the present invention. For example, the processing and functions implemented by the in vitro electronic device and the main control device can be integrated into a single computer device, but such changes still fall within the scope covered by the claims of the present invention.

Claims (19)

1. An electronic therapy system, comprising:

At least one in-vivo electronic device adapted to be disposed within a patient's body, each of the at least one in-vivo electronic device being electrically connected to at least one electrode disposed within the patient's body;

an external electronic device adapted to be arranged outside the patient's body, in wireless connection with the at least one internal electronic device; and

a master control device adapted to be arranged outside the patient's body and to be connected with the external electronic device, either wired or wireless, for controlling and processing the data of the internal and external electronic devices;

the main control device controls and processes the data of the in-vivo electronic device and the in-vitro electronic device, and the main control device comprises: achieving time synchronization of each electronic device according to the time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

the master control device implementing time synchronization of each electronic device according to the time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device includes:

selecting a time axis of any one of the electronic devices as a baseline time;

and adding the difference between the time stamp offset of other electronic devices in the electronic devices and the time stamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the acquired data of the other electronic devices or the actual time for sending the stimulus.

2. The electronic therapy system of claim 1, wherein timing is based on a time stamp offset for each of the at least one in-vivo electronic device and the in-vitro electronic device to achieve time synchronization of each electronic device.

3. The electronic therapy system of claim 1 or 2, wherein the master control device controlling and processing data of the in-vivo electronic device and the in-vitro electronic device further comprises:

and storing and/or displaying the acquired data after time synchronization.

4. The electronic therapy system of claim 3, wherein the master control device controlling and processing data of the in-vivo and in-vitro electronic devices further comprises:

generating a stimulation command or selecting a predefined stimulation command according to the acquired data;

the stimulation command is sent to one or more of the at least one in-vivo electronic device and the in-vitro electronic device.

5. The electronic therapy system of claim 4, wherein the in-vivo electronics that receive the stimulation command generate a stimulation signal based on the stimulation command and transmit the stimulation signal to the corresponding electrode.

6. The electronic therapy system of claim 4, wherein the external electronics that receive the stimulation command send external stimulation to the patient at synchronized times.

7. The electronic therapy system of claim 6, wherein the external stimulus comprises an auditory stimulus, a visual stimulus, a tactile stimulus.

8. The electronic therapy system of claim 1, wherein data of physiological electrical signals of a patient are acquired through the electrodes or stimulus signals are sent to the patient.

9. The electronic therapy system of claim 1, wherein the master control device and the extracorporeal electronic device are integrated on a single apparatus.

10. A control device for use in an electronic therapy system, the control device comprising:

a communication interface in communication with at least one in-vivo electronic device implanted in the patient via an in-vitro electronic device connected thereto;

a memory having stored thereon computer instructions;

a processor for executing the computer instructions to perform the following: achieving time synchronization of each electronic device according to the time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

Wherein the processor executing the computer instructions to achieve time synchronization of each of the at least one in-vivo electronic device and the in-vitro electronic device according to a time stamp offset of the respective electronic device comprises:

selecting a time axis of any one of the electronic devices as a baseline time; and adding the difference between the time stamp offset of each of the other electronic devices in each electronic device and the time stamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the acquired data of the other electronic devices or the actual time of sending the stimulus.

11. The control device of claim 10, wherein the processor executes the computer instructions to perform operations in accordance with a timestamp offset of each of the at least one in-vivo electronic device and the in-vitro electronic device to achieve time synchronization of each electronic device at predetermined time intervals.

12. The control device of claim 11, wherein the predetermined time interval comprises 10 seconds to 200 seconds.

13. The control device of claim 10, wherein the processor executes the computer instructions to store the synchronized acquisition data in the memory or other storage device.

14. The control device of claim 10, further comprising a display, wherein the processor executes the computer instructions to present the synchronized acquisition data via the display.

15. The control device of claim 10, wherein the processor executes the computer instructions to further perform the operations of:

generating a stimulation command or selecting a predefined stimulation command according to the acquired data;

the stimulation command is sent to one or more of the at least one in-vivo electronic device and the in-vitro electronic device.

16. A method for time synchronizing an electronic therapy system, the electronic therapy system comprising an external electronic device and at least one internal electronic device, each of the at least one internal electronic device being electrically connected to at least one electrode disposed within a patient, the method comprising:

acquiring the time stamp offset of each electronic device in the at least one in-vivo electronic device and the in-vitro electronic device;

the time synchronization of each electronic device is realized according to the respective time stamp offset of each electronic device;

Wherein said implementing the time synchronization of each electronic device according to the time stamp offset of each electronic device in the at least one in-vivo electronic device and in-vitro electronic device comprises:

selecting a time axis of any one of the electronic devices as a baseline time;

and adding the difference between the time stamp offset of each of the other electronic devices in each electronic device and the time stamp offset of the electronic device corresponding to the baseline time by taking the baseline time as a reference to obtain the acquired data of the other electronic devices or the actual time of sending the stimulus.

17. The method of claim 16, wherein the steps of the method are performed at predetermined time intervals.

18. The method of claim 17, wherein the predetermined time interval comprises 10 seconds to 200 seconds.

19. A computer readable storage medium having stored thereon computer instructions which, when executed by a processor, implement the method of any of claims 16 to 18.