CN116604816B

CN116604816B - A method for 3D printing scleral lenses for keratoconus based on digital medical technology

Info

Publication number: CN116604816B
Application number: CN202310645291.9A
Authority: CN
Inventors: 李占元; 林江; 蒋可; 刘剑; 戴创; 黎崎鸿; 林致扬
Original assignee: Aier Eye Hospital Group Sichuan Eye Hospital Co ltd; Aier Eye Hospital Group Co Ltd
Current assignee: Aier Eye Hospital Group Sichuan Eye Hospital Co ltd; Aier Eye Hospital Group Co Ltd
Priority date: 2023-06-01
Filing date: 2023-06-01
Publication date: 2025-12-02
Anticipated expiration: 2043-06-01
Also published as: CN116604816A

Abstract

The invention belongs to the technical field of sclera lens forming devices, and particularly relates to a method for printing sclera lens for keratoconus based on digital medical treatment 3D, which comprises the following steps of creating a three-dimensional model by using computer aided design and manufacturing software, combining clinical departments and 3D technology through interdisciplinary cooperation, realizing personalized design of sclera contact lens for keratoconus patients by using 3D printing technology in combination with digital medical treatment, referring to the research of the prior art in China, carrying out research and development based on SD-OCT, and achieving the purposes of wide AS-OCT with imaging width of 18mm and depth of 7mm, covering the whole cornea sclera area, shooting a complete 3D image, quickly and repeatedly obtaining the image, deeply learning a network, combining artificial intelligence, identifying the front and rear surfaces, lenses, tear layers, cornea and sclera boundaries, outputting visual data and graphs through the network, improving accuracy, reducing measurement rise errors and the like on the subjective aspect of doctors, improving safety and curative effect, and shortening manufacturing process.

Description

Method for printing scleral lens for keratoconus based on digital medical 3D

Technical Field

The invention relates to the technical field of sclera lens forming devices, in particular to a method for printing sclera lens for keratoconus based on digital medical 3D.

Background

At present, individuation of medical treatment is one of the development directions of medicine in the 21 st century, 3D printing technology is a new technology generated by combining digital and intelligent manufacturing with material science, also called as a rapid forming technology or an additive manufacturing technology, is an accumulated manufacturing technology for creating objects by printing materials layer by using a digital model, 3D printing can realize low-cost design and production tools, helps early find common eye diseases, is special for diagnosis and treatment equipment built for individual patients, 3D prints contact lenses and intraocular implants, assists operation planning, improves models of education of patients and medical staff and the like, and can become a part of mainstream medicine in various ophthalmic applications. Scleral lenses are a specially designed large diameter rigid oxygen permeable contact lens. Broadly, scleral lenses include corneoscleral lenses (also known as limbal lenses, half-scleral lenses), which refer to lens landing zones partially on the cornea and partially on the sclera, and full-scleral lenses (also known as true scleral lenses), which refer to lens landing zones entirely on the anterior surface of the sclera. The scleral lens has wide application prospect, can provide mechanical protection for cornea, and has great potential in improving vision quality and life quality of various eye disease patients.

The common indications of the scleral lens are 1, the diseases causing irregular astigmatism of cornea, such as irregular astigmatism caused by corneal scar, corneal degeneration or malnutrition, corneal trauma, obvious scar and serious irregular astigmatism caused by keratoconus, corneal dilatation, corneal transplantation, herpes simplex virus infection and the like. 2. The scleral lens can cross the limbus and can not move on the cornea, so that the functions of improving the osmotic pressure of tears, promoting the healing of corneal epithelium, forming tears after the lens and continuously supplementing water for the ocular surface are achieved, and the ocular surface is protected.

Parameters required by clinical sclera-up lens adaptation in the prior art comprise 1, cornea sclera morphology, 2, cornea sagittal heights in different meridian orientations, 3, turning angles of different meridian corneas, 4, thickness of tear lens and distribution thereof, 5, sinking rule of tear lens and the like. The clinical dilemma is that 1, trial and error, 2, time consumption, 3, the growth period of doctor experience is obviously prolonged compared with other contact lens doctors, experienced doctor's phoenix-skin angle is prolonged, 4, cost is relatively high, 5, the acquisition method of adaptive parameters is limited to acquiring the sagittal height (OCT) at the chord length of less than 15mm, most of the technologies cannot acquire the thickness of the whole under-lens tear, the OCT in a small range needs to be shot for many times, the whole sclera morphology evaluation information is lacking, an ESP (electronic stability program) eye profilometer and the like are arranged abroad, the imaging range is slightly larger, but the lens wearing effect is not seen, limitation is caused, the cornea morphology detection is applied to a cornea topography map, based on the current clinical work, the experiment of SCL of irregular cornea and serious eye surface diseases, such as the difficulty of a patient of keratoconus is large, the experiment fitter or doctor needs to try many times to determine relatively satisfactory lens customization parameters, the repeated trial wearing process and the patient is required to observe about 2 hours to evaluate the thickness change of the under-lens, thus not only increasing uncomfortable feeling of the patient, but also increasing the risk of corneal epithelium or falling off.

Disclosure of Invention

The invention aims to provide a method for printing scleral lens for keratoconus based on digital medical treatment 3D, which solves the problem of higher difficulty in the test and the matching of the keratoconus SCL for irregular cornea and serious ocular surface diseases based on the current clinical work.

The method for printing scleral lens for keratoconus based on digital medical treatment 3D comprises the following steps of S1, creating a three-dimensional model by using computer aided design and manufacturing software, establishing a patient personalized finite element model, and simulating dynamic compression of an eyeball, namely eyelid pressure, under-lens tear tension and actually measured intraocular pressure when the scleral lens is worn and measured by using finite element analysis software;

S2, combining a 3D printing technology, realizing the micro-nano 3D printing technology, and directly or indirectly manufacturing the scleral mirror by using the existing material, wherein the technology adopts a plane projection micro-stereo lithography technology;

Step S3, designing the digital medical data into an indirect die, completely presenting the optical curvature condition to be corrected, and relieving the curvature condition of the traditional processing in the multi-order equation so that the correction curative effect is better;

s4, discussing a 3D printing technology, designing the complex condition of the digital medical data into an indirect die, and realizing quadrant optimization design;

S5, realizing personalized sclera customization, precisely designing a three-dimensional model of the sclera, which accords with the optical curvature of the patient and the cornea sclera shape, by combining optical data, intelligently predicting the sinking rule data of the lens, and realizing customizing the sclera by a 3D printing technology;

step S6, individuating notes of customized scleral lenses, wherein the existing scleral lens printing technology is immature, needs to be researched and observed for continuous improvement, is not common, and can harm the health of eyeballs if abnormal conditions are not treated in time;

and S7, cleaning and disinfecting the customized sclera lens, so that the patient can be more clean when using the lens, the lens is beneficial to eye health, the lens is soaked in the full-function nursing liquid for more than 4 hours to wear, the concave surface of the lens is dripped with 0.9% physiological saline before wearing, protein removal nursing is recommended for 1 time a week, the soaking time is not more than half an hour, and the lens is soaked in the nursing liquid for more than 4 hours after being washed with 0.9% physiological saline after being soaked.

Preferably, in the step S1, the specific steps of creating the three-dimensional model using the computer aided design and manufacturing software are:

(1) Establishing a three-dimensional finite element model of a whole eyeball and a sclera lens based on dynamic ocular surface topographic map data of an OCT image of a wide-angle anterior segment of the eye, wherein the whole eyeball and sclera lens mechanical contact finite element model comprises a whole eyeball model and a sclera lens model, researching the prior forefront in China by reference, developing a large-range fault scanner based on a spectral domain optical coherence tomography imaging system, and acquiring an individual characteristic image with an irregular form of the ocular surface of a patient, wherein the imaging width is more than 18mm and the depth is more than 7mm, covering the whole cornea sclera area, shooting a complete 3D image only for 0.3 seconds, being rapid and high in repeatability, solving the problem of deformation correction of the OCT image under any condition by an image reconstruction error deformation correction algorithm;

(2) Through simulating and calculating the thickness distribution of the tear mirror and the compressive deformation and stress distribution of the ocular surface, after an image is obtained, a deep learning network and artificial intelligence are combined, the front surface, the rear surface, the lens, the tear layer, the cornea and the boundary of the sclera are identified, the dissymmetry of the sclera and the cornice limbus area is realized, the network outputs visual data and figures, the accuracy is improved, the personalized design is realized, and therefore, the subjective measurement rise errors and the like for doctors are reduced, and the safety and the curative effect are improved;

(3) The model is optimized by a reverse analysis method (starting from the problem, the knowledge requirement and the related basic problem are deduced step by step to solve the problem to be solved or obtain the knowledge requirement).

Preferably, in the step S2, a 3D printing technology is combined, and the specific steps of implementing the micro-nano 3D printing technology are as follows:

(1) Setting a dynamic ocular surface topographic map output by the model as simulation data;

(2) Fitting the fitting data of each region with the target data as much as possible by adopting a reverse analysis method;

(3) The three-dimensional model of the sclera lens, which is in accordance with the optical curvature and the appearance of the corneosclera of the patient, is precisely designed by combining doctors with optical data, and rule data of lens sinking is intelligently predicted by combining OCT data.

Preferably, in the step S3, the specific step of designing the digitized medical data into the indirect type includes:

(1) Using a high-precision position photoetching projection system to project a pattern to be printed onto the liquid level of a resin tank, solidifying the resin on the liquid level and rapidly forming into a three-dimensional shape;

(2) Directly processing a three-dimensional complex model and a sample from the digital model to finish product production;

(3) And polishing the 3D printing directly manufactured scleral lens product or the scleral lens indirectly manufactured mold in a chemical vapor polishing mode to ensure that the surface roughness of the mold is below 5 nm.

Preferably, in the step S4, a complex condition of the digitized medical data based on the 3D printing technology is studied and designed as an indirect mold, and a three-dimensional finite element model of the whole eyeball and the sclera is established based on the dynamic ocular surface topographic map data of the OCT image of the wide-angle anterior segment of the eye by applying the current clinical sclera experimental technique theory.

Preferably, in the step S5, personalized scleral customization is achieved, and the design of the scleral mainly has four aspects:

(1) The scleral lens mainly comprises a central tear area, an angle consolidated edge area and a scleral landing area, wherein the central tear area is arched in the center of a cornea, stabilizes proper thickness of the tear under the lens, and customizes clear vision;

(2) In terms of the shape of the lens, including oblate and prolate, the oblate shape is suitable for normal eye, eye and after refractive surgery, mild corneal ectasia, etc., and the prolate shape is suitable for severe corneal ectasia and various keratoconus, etc.;

(3) Three design types of full-arc area personalized customization are available, including spherical surface, annular curve and multifocal, and the shape of the cornea sclera is more fit to the eye surface;

(4) The quadrant specific adjustment scheme is to adjust the horizontal and vertical diameters and the hemispherical or ellipsoidal height on different quadrants to make the lens more fit the front surface of cornea.

Preferably, in the step S6, the notice of personalized scleral lens occurs, and the surface of the notice is specifically that the scleral lens is an external tissue of a human body, is attached to the surface of the eye, and can change the physiological environment and metabolism of the surface of the eye, interfere with the structure of the surface of the eye, thereby inducing some complications, and the hypoxia-responsive lens material and the thickness problem of the lens can generate the condition of corneal hypoxia, so that corneal edema, epithelial thinning, sensitivity reduction, neovascularization and endothelial cell reduction are caused, immune response and inflammation are more common in atopic diseases, surface diseases of the eye and postoperative eyes, lens adhesion is not common after the lens is worn for a long time, but the eye health is endangered if the treatment is not timely carried out, so the design of the customized full-curvature scleral lens is more important.

Preferably, in the step S7, the customized scleral lens should be soaked in the full-functional nursing solution for more than 4 hours for wearing, the concave surface of the lens is dripped with 0.9% physiological saline before wearing, then wearing is performed, 1-time deproteinization nursing is recommended, the soaking time is not more than half an hour, after soaking, the lens is rinsed with 0.9% physiological saline, and then soaked in the nursing solution for more than 4 hours, and the safety wearing is guaranteed by strict nursing.

Compared with the prior art, the invention has the following beneficial effects:

1. The invention has the advantages that clinical departments and 3D technology are in interdisciplinary cooperation and combined with digital medical treatment, the personalized design sclera contact lens of keratoconus patients is manufactured by 3D printing technology, large-scale AS-OCT (analog-to-digital) research and development is performed based on SD-OCT by referring to the prior forefront research in China, the imaging width is more than 18mm, the depth is more than 7mm, the whole cornea sclera area is covered, a complete 3D image is shot, the imaging is only required to be quick and high in repeatability, after the image is obtained, the problem of deformation correction of OCT image under any condition is solved by an image reconstruction error deformation correction algorithm, the individual characteristic image of irregular forms of the eye surface of the patients is obtained, a deep learning network is combined with artificial intelligence, the front surface and the rear surface, the tear layer, the boundary of the cornea and the boundary of the sclera are identified, the dissymmetry of the sclera and the corneosclera limbus area is output by the network, visual data and graphics are improved, the personalized design is realized, the subjective measurement vector high error and the like are reduced for doctors, and the safety and the curative effect are improved.

2. The invention has the beneficial effects that the sclera lens test and distribution technology theory of keratoconus is applied, the advantages of OCT3D data are fully applied, specifically, the low-coherence light interference principle, non-contact, non-invasive, non-radiative and high-resolution fault imaging is adopted, the key is that the sclera lens with different meridian directions, including the form and quantization angle of the sclera lens, the sagittal curve, the regular symmetry of the sclera lens and the like can be automatically calculated based on the boundary of OCT3D image segmentation, and the sclera lens with various quadrants and personalized designs can be realized by combining with the corneal topography and the like.

3. The invention has the advantages that the digital reconstruction and 3D printing technology is used for customizing the feasibility of the sclera of the keratoconus patient, the optical data is combined, the optimization design and the manufacturing software are combined to create the three-dimensional model of the sclera which accords with the eye shape of the patient, and the 3D printing technology is combined to customize the sclera sample to realize the highly personalized customization of the sclera by 3D printing, thereby achieving the purpose of shortening the manufacturing process and reducing the economic cost.

Drawings

FIG. 1 is a graph of the optical curvature of an ocular condition of a keratoconus patient according to the present invention;

FIG. 2 is a diagram of a personalized scleral three-dimensional model of scleral morphology in accordance with the present invention;

FIG. 3 is a chart showing the 3D printing effect of the scleral lens according to the present invention;

FIG. 4 is a graph showing the effect of the indirect scleral lens manufacturing mold of the present invention before polishing;

FIG. 5 is a graph showing the effect of the indirect scleral lens manufacturing mold of the present invention after polishing;

FIG. 6 is a graph of sagittal elevation versus integrated reconstructed scleral topography for various meridional directions of the present invention;

fig. 7 is a diagram showing the effect of the present invention.

Detailed Description

The following description of the embodiments of the present invention will be made clearly and completely with reference to the accompanying drawings, in which it is apparent that the embodiments described are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.

Embodiment one:

Referring to fig. 1-7, a method for printing scleral lens for keratoconus based on digital medical 3D printing includes the steps of;

The method comprises the following steps of S1, creating a three-dimensional model by using computer aided design and manufacturing software, creating a patient personalized finite element model, simulating dynamic compression of an eyeball, namely eyelid pressure, under-lens tear tension and actually measured intraocular pressure when the sclera is worn and measured by using finite element analysis software, wherein in the step S1, the specific steps of creating the three-dimensional model by using the computer aided design and manufacturing software are that (1) the three-dimensional finite element model of the whole eyeball and the sclera is built by using dynamic ocular surface topographic map data based on wide-angle anterior segment OCT images, the mechanical contact finite element model of the whole eyeball and the sclera comprises two parts of the whole eyeball model and the sclera model, and a wide-range fault scanner is researched and developed based on a spectral domain optical coherence tomography imaging system by referring to the research of the prior art, the imaging width is 16mm, the depth is 5mm, the whole cornea area is covered, and a complete 3D image is shot, and the method is quick and high in repeatability; through image reconstruction error deformation correction algorithm, the deformation correction problem of OCT image is solved under any condition, the individual characteristic image of irregular form of eye surface of patient is obtained, 2, after the image is obtained by simulating the thickness distribution of tear lens and the compression deformation and stress distribution of eye surface, the network is learned by depth, the combination of artificial intelligence, the front and back surfaces, the lens, tear layer, cornea and sclera boundary are identified, the asymmetry of sclera and cornice edge area is identified, visual data and graph are output by network, the accuracy is improved, personalized design is realized, thereby reducing the measurement vector error subjectively to doctor, etc., improving the safety and curative effect, 3, by reverse analysis method (beginning with the problem, the knowledge-needed conditions and the related basic problems thereof needed by solving the problem to be solved or obtaining the knowledge-needed conditions are deduced step by step) to optimize the model.

The method comprises the steps of S2, combining a 3D printing technology, realizing the micro-nano 3D printing technology, directly or indirectly manufacturing the sclera lens by using the existing materials, and adopting a surface projection micro-stereo lithography technology, wherein in the step S2, combining the 3D printing technology, the specific steps of realizing the micro-nano 3D printing technology are (1) setting a dynamic ocular surface topographic map output by a model as analog data, (2) adopting a reverse analysis method to enable fitting data of all areas to be attached to target data as much as possible, and (3) combining doctors to provide optical data to accurately design a three-dimensional model of the sclera lens, which meets the optical curvature and sclera morphology of a patient, and combining OCT data to intelligently predict the sinking rule data of the lens.

The method comprises the steps of S3, designing digital medical data into an indirect mould, completely presenting the optical curvature condition to be corrected, relieving the traditional curvature condition processed in a multi-order equation, and enabling the correction curative effect to be better, wherein the specific steps of the step S3, designing the digital medical data into the indirect mould are that (1) a high-precision job position photoetching projection system is used, a pattern to be printed is projected to the liquid surface of a resin tank, resin is solidified on the liquid surface and is rapidly formed into a three-dimensional shape, (2) a three-dimensional complex model and a sample are directly processed from the digital model, and product production is completed, and (3) the 3D printing is directly performed to manufacture a scleral mirror product or the scleral mirror indirect manufacturing mould through a chemical vapor polishing mode, so that the surface roughness of the scleral mirror product is less than 5 nm.

And S4, discussing a 3D printing technology-based die for designing the complex condition of the digital medical data into an indirect type die to realize quadrant optimization design, wherein in the step S4, discussing the 3D printing technology-based die for designing the complex condition of the digital medical data into an indirect type die, and establishing a three-dimensional finite element model of the whole eyeball and the sclera based on dynamic ocular surface topographic map data of OCT images of the front section of the wide-angle eye by applying the current clinical sclera experimental technique theory.

The method comprises the steps of S5, realizing personalized sclera customization, precisely designing a three-dimensional model of the sclera, which accords with the optical curvature of a patient' S condition and the morphology of cornea and sclera, combining optical data, intelligently predicting the sinking rule data of a lens, and realizing the customization of the sclera by a 3D printing technology, wherein in the step S5, the personalized sclera customization is realized, the sclera is mainly designed in four aspects, namely (1) the main structure of the sclera comprises a central tear area, an angle-consolidated edge area and a sclera landing area, the central tear area is arched in the center of cornea, stabilizes the proper thickness of tears under the lens, customizes clear vision, the angle-consolidated edge area provides independently designed contact area of the cornea and the sclera, and the contact area of the sclera is shown, and the contact area of the lens is shown, and the oblate shape of the lens is suitable for normal eyes, after refractive surgery, slight corneal expansion and the like, and (3) the contact area of the sclera is suitable for severe corneal expansion and various keratoconus and the like, and the contact area is suitable for the spherical surface, the contact area is more suitable for the contact with the spherical surface, the contact surface of the contact lens or the contact surface of the contact lens, and the contact lens is more than the spherical surface of the contact lens or the contact lens.

In the step S6, the attention of the personalized customized sclera lens is specifically that the sclera lens is an external tissue of a human body and is attached to the surface of the eye, the physiological environment and metabolism of the surface of the eye can be changed, the structure of the surface of the eye is disturbed, thereby inducing some complications, the hypoxia-responsive lens material and the thickness problem of the lens can generate the situation of corneal hypoxia, resulting in corneal edema, epithelial thinning, sensitivity reduction, neovascularization and endothelial cell reduction, immune response and inflammation, which are more common in atopic diseases, ocular surface diseases and postoperative eyes, and lens adhesion can occur after long-term wearing of the lens, but are not common, so that the design of the customized scientific and reasonable full-curvature sclera lens is more important.

And S7, cleaning and disinfecting the customized sclera lens, so that the patient can be more clean when using the lens, the lens is beneficial to eye health, the lens is soaked in the full-function nursing liquid for more than 4 hours to wear, the concave surface of the lens is dripped with 0.9% physiological saline before wearing, protein removal nursing is recommended for 1 time a week, the soaking time is not more than half an hour, the lens is soaked in the nursing liquid after being washed with 0.9% physiological saline, and the safety of wearing is guaranteed by strict nursing.

Embodiment two:

The method comprises the following steps of S1, creating a three-dimensional model by using computer aided design and manufacturing software, creating a patient personalized finite element model, simulating dynamic compression of an eyeball, namely eyelid pressure, under-lens tear tension and actually measured intraocular pressure when the sclera is worn and measured by using finite element analysis software, wherein in the step S1, the specific steps of creating the three-dimensional model by using the computer aided design and manufacturing software are that (1) the three-dimensional finite element model of the whole eyeball and the sclera is built by using dynamic ocular surface topographic map data based on wide-angle anterior segment OCT images, the mechanical contact finite element model of the whole eyeball and the sclera comprises two parts of the whole eyeball model and the sclera model, and a wide-range fault scanner is researched and developed based on a spectral domain optical coherence tomography imaging system by referring to the research of the prior art, the imaging width is 19mm, the depth is 8mm, the whole cornea area is covered, and a complete 3D image is shot, and the method is quick and high in repeatability; through image reconstruction error deformation correction algorithm, the deformation correction problem of OCT image is solved under any condition, the individual characteristic image of irregular form of eye surface of patient is obtained, 2, after the image is obtained by simulating the thickness distribution of tear lens and the compression deformation and stress distribution of eye surface, the network is learned by depth, the combination of artificial intelligence, the front and back surfaces, the lens, tear layer, cornea and sclera boundary are identified, the asymmetry of sclera and cornice edge area is identified, visual data and graph are output by network, the accuracy is improved, personalized design is realized, thereby reducing the measurement vector error subjectively to doctor, etc., improving the safety and curative effect, 3, by reverse analysis method (beginning with the problem, the knowledge-needed conditions and the related basic problems thereof needed by solving the problem to be solved or obtaining the knowledge-needed conditions are deduced step by step) to optimize the model.

And (3) taking imaging width and imaging depth as indexes, designing n groups of tests (table 1), comparing and analyzing with the actual scanning effect, and determining the optimal combination as the scanning position.

Table 1 test design

According to the 4 groups of experimental data, compared with comparative example 1, the optimal combination can be achieved when the imaging width is 20mm and the imaging depth is 9mm, so that the optimal scanning position with the imaging width of 20mm and the imaging depth of 9mm can be determined.

Although embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made therein without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.

Claims

1. A method for printing scleral lens for keratoconus based on digital medical 3D, which is characterized by comprising the following steps:

step S1, creating a three-dimensional model by using computer aided design and manufacturing software, creating a patient personalized finite element model, and simulating dynamic compression of eyeballs, namely eyelid pressure, under-lens tear tension and actually measured intraocular pressure when the sclera lens is worn and measured by using finite element analysis software;

step S3, designing the digital medical data into an indirect mold, and completely presenting the optical curvature condition to be corrected;

Step S6, the personalized customized scleral lens needs to deal with abnormal conditions in time, needs to be researched and observed for continuous improvement, is not common, and can harm the health of eyeballs if some abnormal conditions are not timely handled;

Step S7, cleaning and nursing the customized sclera lens, so that a patient can use the customized sclera lens cleaner, soaking the lens cleaner for more than 4 hours after the full-function nursing liquid is cleaned, putting on the lens cleaner before putting on the lens cleaner, dripping physiological saline on the lens cleaner before putting on the lens cleaner, nursing the lens cleaner for 1 time a week, wherein the soaking time is not more than half an hour, and soaking the lens cleaner in the nursing liquid for more than 4 hours after flushing the lens cleaner with 0.9 percent physiological saline after soaking the lens cleaner;

In the step S1, the specific steps of creating the three-dimensional model using the computer aided design and manufacturing software are:

(1) Establishing a three-dimensional finite element model of a whole eyeball and a sclera lens based on dynamic eye surface topographic map data of an OCT image of a wide-angle anterior segment of the eye, wherein the three-dimensional finite element model of the whole eyeball and the sclera lens comprises two parts of the whole eyeball model and the sclera lens model, developing a large-scale fault scanner based on a spectral domain optical coherence tomography imaging system, and covering the whole cornea sclera area, shooting a complete 3D image for 0.3 seconds, solving the problem of deformation correction of the OCT image under any condition through an image reconstruction error deformation correction algorithm, and obtaining an individual characteristic image of irregular form of the eye surface of a patient;

(2) After an image is obtained by simulating and calculating the thickness distribution of a tear mirror and the compression deformation and stress distribution of an ocular surface, the combination of a deep learning network and artificial intelligence identifies the boundaries of the front surface, the rear surface, a lens, a tear layer, a cornea and a sclera, determines the asymmetry of the sclera and a cornice limbus area, and the network outputs visual data and a graph, so that the accuracy is improved, the personalized design is realized, and the subjective measurement rise error of a doctor is reduced;

(3) The three-dimensional finite element model is optimized by a reverse analysis method, namely starting with the problem, and reversely pushing out the to-be-solved problem step by step or obtaining the to-be-known condition and the related basic problem thereof.

2. The method for printing scleral lens for keratoconus based on digital medical treatment 3D according to claim 1, wherein in the step S2, the specific steps of implementing micro-nano 3D printing technology by combining 3D printing technology are as follows:

(3) The three-dimensional model of the sclera lens, which is in accordance with the optical curvature and sclera morphology of the cornea of the patient, is precisely designed by combining with the optical data provided by doctors, and the rule data of lens sinking is intelligently predicted by combining with OCT data.

3. The method for digital medical 3D printing of scleral lenses for keratoconus according to claim 1, which is specific

Characterized in that in the step S3, the specific steps of designing the digitized medical data into the indirect type are as follows:

(1) Using a high-precision photoetching projection system to project a pattern to be printed onto the liquid surface of a resin tank, solidifying the resin on the liquid surface and rapidly and three-dimensionally forming;

4. The method for printing scleral lens for keratoconus based on digital medical treatment 3D according to claim 1, wherein in the step S4, the complex condition of the digital medical treatment data is designed into an indirect mold based on the 3D printing technology, and a three-dimensional finite element model of the whole eyeball and the scleral lens is established based on the dynamic ocular surface topographic map data of the OCT image of the anterior segment of the wide-angle eye by applying the current clinical scleral lens test and matching technology theory.

5. The method for digital medical 3D printing keratoconus based on claim 1, wherein in step S5, personalized scleral lens customization is achieved, and the design of the scleral lens mainly takes into consideration:

(2) In terms of lens shape, including oblate and prolate, the oblate shape is suitable for normal eye, eye and post refractive surgery, mild corneal ectasia conditions, the prolate shape is suitable for severe corneal ectasia and various keratoconus conditions;

6. A method for digital medical 3D printing of a keratoconus as defined in claim 1, wherein in step S6, the abnormal condition includes a lens inducing complications, hypoxia response, i.e. a condition in which the lens material and thickness of the lens are subject to corneal hypoxia, resulting in corneal oedema, epithelial thinning, decreased sensitivity, neovascularization and endothelial cell depletion, immune response and inflammation, and lens blocking after extended wear of the lens.

7. The method for printing scleral lens for keratoconus based on digital medical treatment 3D according to claim 1, wherein in the step S7, the customized scleral lens is cleaned and soaked by a full-function nursing liquid for more than 4 hours, physiological saline is dripped into the concave surface of the lens before wearing, the lens is worn again, protein removal nursing is carried out for 1 time a week, the soaking time is not more than half an hour, the lens is soaked in the nursing liquid after being washed by 0.9% physiological saline, and the lens is strictly nursed to ensure safe wearing.