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CN1164855A - 含有连接碳环的取代苯并咪唑碱的抗病毒核苷类似物 - Google Patents

含有连接碳环的取代苯并咪唑碱的抗病毒核苷类似物 Download PDF

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Publication number
CN1164855A
CN1164855A CN95196148A CN95196148A CN1164855A CN 1164855 A CN1164855 A CN 1164855A CN 95196148 A CN95196148 A CN 95196148A CN 95196148 A CN95196148 A CN 95196148A CN 1164855 A CN1164855 A CN 1164855A
Authority
CN
China
Prior art keywords
chloro
benzoglyoxaline
methylol
compound
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN95196148A
Other languages
English (en)
Chinese (zh)
Inventor
L·B·汤森
S·M·达卢吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
University of Michigan System
Original Assignee
Wellcome Foundation Ltd
University of Michigan System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/304,006 external-priority patent/US5534535A/en
Application filed by Wellcome Foundation Ltd, University of Michigan System filed Critical Wellcome Foundation Ltd
Publication of CN1164855A publication Critical patent/CN1164855A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN95196148A 1994-09-09 1995-09-11 含有连接碳环的取代苯并咪唑碱的抗病毒核苷类似物 Pending CN1164855A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/304,006 1994-09-09
US08/304,006 US5534535A (en) 1992-03-09 1994-09-09 Therapeutic nucleosides

Publications (1)

Publication Number Publication Date
CN1164855A true CN1164855A (zh) 1997-11-12

Family

ID=23174626

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95196148A Pending CN1164855A (zh) 1994-09-09 1995-09-11 含有连接碳环的取代苯并咪唑碱的抗病毒核苷类似物

Country Status (17)

Country Link
EP (1) EP0779885A1 (fr)
JP (1) JPH10505092A (fr)
CN (1) CN1164855A (fr)
AP (1) AP741A (fr)
AU (1) AU3692895A (fr)
BR (1) BR9508826A (fr)
CA (1) CA2199502A1 (fr)
CZ (1) CZ71297A3 (fr)
FI (1) FI970959A7 (fr)
HU (1) HUT77440A (fr)
IS (1) IS4436A (fr)
NO (1) NO971070L (fr)
NZ (1) NZ294095A (fr)
OA (1) OA10601A (fr)
PL (1) PL319440A1 (fr)
SK (1) SK29197A3 (fr)
WO (1) WO1996007646A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5912356A (en) * 1995-09-11 1999-06-15 Glaxo Wellcome Inc. Antiviral nucleoside analogues containing a substituted benzimidazole base attached to a carbocyclic ring
GB9600142D0 (en) * 1996-01-05 1996-03-06 Wellcome Found Chemical compounds
AU6221998A (en) 1997-02-13 1998-09-08 Glaxo Group Limited Benzimidazole derivatives
CN1272113A (zh) 1997-07-30 2000-11-01 密歇根大学董事会 作为抗病毒剂的来苏呋喃糖基苯并咪唑类化合物
CA2363274A1 (fr) 1999-12-27 2001-07-05 Japan Tobacco Inc. Composes a noyaux fusionnes et leurs utilisations comme medicaments contre l'hepatite c
US6770666B2 (en) 1999-12-27 2004-08-03 Japan Tobacco Inc. Fused-ring compounds and use thereof as drugs
GB0008939D0 (en) 2000-04-11 2000-05-31 Glaxo Group Ltd Process for preparing substituted benzimidazole compounds
AR035543A1 (es) * 2001-06-26 2004-06-16 Japan Tobacco Inc Agente terapeutico para la hepatitis c que comprende un compuesto de anillo condensado, compuesto de anillo condensado, composicion farmaceutica que lo comprende, compuestos de benzimidazol, tiazol y bifenilo utiles como intermediarios para producir dichos compuestos, uso del compuesto de anillo con
JP5479336B2 (ja) 2007-08-02 2014-04-23 ミレニアム ファーマシューティカルズ， インコーポレイテッド Ｅ１活性化酵素阻害剤の合成のためのプロセス

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9205071D0 (en) * 1992-03-09 1992-04-22 Wellcome Found Therapeutic nucleosides

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1834090B (zh) * 2005-03-18 2011-06-29 中国科学院上海药物研究所 苯并咪唑类化合物、其制备方法以及用途

Also Published As

Publication number Publication date
JPH10505092A (ja) 1998-05-19
HUT77440A (hu) 1998-04-28
OA10601A (en) 2002-09-03
IS4436A (is) 1997-03-07
SK29197A3 (en) 1997-10-08
CZ71297A3 (en) 1997-08-13
AP741A (en) 1999-04-26
WO1996007646A1 (fr) 1996-03-14
BR9508826A (pt) 1997-09-30
AP9700940A0 (en) 1997-04-30
FI970959A0 (fi) 1997-03-06
NZ294095A (en) 1998-08-26
NO971070D0 (no) 1997-03-07
AU3692895A (en) 1996-03-27
EP0779885A1 (fr) 1997-06-25
FI970959A7 (fi) 1997-05-06
PL319440A1 (en) 1997-08-04
MX9701789A (es) 1997-10-31
CA2199502A1 (fr) 1996-03-14
NO971070L (no) 1997-05-07

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C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C01 Deemed withdrawal of patent application (patent law 1993)
WD01 Invention patent application deemed withdrawn after publication