CN116407478A - Mild acne-removing composition and application thereof - Google Patents

Abstract

The invention discloses a mild acne-removing composition and application thereof, wherein the mild acne-removing composition comprises the following components in parts by weight: 1-5 parts of succinic acid, 0.05-0.5 part of centella asiatica total glycosides and 5-25 parts of Norway spruce leaf extract. According to the invention, by reasonably preparing succinic acid, total glycosides of centella asiatica and Norway spruce leaf extract, from the principle of acne formation, sebum peroxidation is reduced, acne factor propionibacterium acnes are inhibited, inflammation and immune response caused by sebum peroxidation products and propionibacterium acnes are reduced, and follicular sebaceous duct keratinization abnormality is relieved; helps to metabolize keratinized abnormal cells, dredges pores, and effectively promotes quick removal of acnes and acnes through synergistic effects of the three components. The invention can obviously reduce the irritation of succinic acid to skin by the combined action of centella asiatica total glycosides and Norway Yun Shanshe extract, so that the acne-removing composition prepared by the invention has mildness at the same time.

Description

A mild acne-removing composition and its application

technical field

The invention relates to the technical field of skin care products, in particular to a mild acne-removing composition and its application.

Background technique

Acne is a chronic inflammatory skin disease of the pilosebaceous unit that occurs in adolescence and mainly affects the face. Studies have found that more than 95% of people will have acne to varying degrees, which has a great impact on the physical and mental health of patients. Under the genetic background, hormone-induced excessive secretion of sebaceous glands, abnormal keratinization of pilosebaceous ducts, proliferation of hair follicle microorganisms such as Propionibacterium acnes, and inflammation and immune responses are related to the pathogenesis of acne.

Commonly used topical drugs for acne treatment include VA acids, antibacterial drugs, etc. However, the use of VA acids often causes skin irritation and may increase skin sensitivity, and the use of antibacterial drugs may also cause skin irritation and drug resistance. There are also acne skin care products that use salicylic acid, etc., but salicylic acid is difficult to dissolve directly in water, and the effect of salicylic acid will be greatly reduced through neutralization and dissolution, and the pH after neutralization is too high to be used in skin care products. Dissolved by techniques such as solubilization, it is generally more irritating. Compared with topical medicines and salicylic acid skin care products, acne skin care products that balance mildness and efficacy are more expected by consumers.

Among the existing anti-acne products, such as patent document CN114209626A, a composition for removing acne and scars is described, which is prepared with asiaticoside, Sophora flavescens extract and Salvia miltiorrhiza extract as functional components, but its effect on acne The highest inhibition rate of propionibacterium is only 75-90%, and the effect still needs to be improved. Patent document CN105434195A describes a composition that has the functions of removing acne and inhibiting the formation of acne scars. Although it has a very good effect of removing acne, its formula is complicated and there are as many as 9 effective components.

Therefore, it is particularly necessary to develop a kind of anti-acne skin care product with simple formula and taking into account mildness and efficacy.

Contents of the invention

Aiming at the deficiencies of the prior art, the object of the present invention is to provide a mild acne-removing composition and its application.

The purpose of the present invention is achieved by the following technical solutions:

In a first aspect, the present invention provides a mild acne-removing composition, comprising the following components in parts by weight:

1-5 parts of succinic acid,

Centella asiaticoside 0.05-0.5 part,

Norway spruce leaf extract 5-25 parts.

As a preferred version, the mild acne-removing composition includes the following components in parts by weight:

5 parts of succinic acid,

Centella asiaticoside 0.5 part,

Norway spruce leaf extract 5 parts.

As a preferred version, the mild acne-removing composition includes the following components in parts by weight:

1 part succinic acid,

Centella asiaticoside 0.05 part,

Norway spruce leaf extract 25 parts.

As a preferred solution, the total asiaticoside includes madecassoside in a weight ratio greater than 50%.

As a preferred solution, the total asiaticosides further includes 10-24.99% asiaticoside and 25-49.99% centella asiaticoside extract by weight.

In the second aspect, the present invention provides an application of the aforementioned mild acne-removing composition in the preparation of skin care products.

As a preferred solution, the dosage form of the skin care product is any one of cream, lotion, water, essence, mask, gel, base makeup, spray and cleansing products.

As a preferred solution, the addition amount of the anti-acne composition in skin care products is 6.05-30.5%.

In a third aspect, the present invention provides an acne-removing essence, which includes the aforementioned mild acne-removing composition, and at least one of a pH regulator, a stabilizer, a moisturizer, a thickener, and a preservative.

As a preferred solution, the pH regulator may be NAOH, but not limited thereto, as long as the pH of the acne-removing essence can be adjusted to 3.5-4.0.

As a preferred solution, the stability may be EDTA-2Na, but not limited thereto.

As a preferred solution, the moisturizing agent may be glycerin, butanediol, DC2501WAX, but not limited thereto.

As a preferred solution, the thickener may be Diutan Gum, but not limited thereto.

As a preferred solution, the preservative may be p-hydroxyacetophenone or 1,2-hexanediol, but not limited thereto.

As a preferred solution, the acne-removing essence also includes other functional ingredients. For example, to obtain the effect of brightening skin tone at the same time, ingredients with skin lightening effect can be added accordingly; ingredients, etc.

Compared with the prior art, the present invention has the following beneficial effects:

1) The present invention reduces sebum peroxidation, inhibits the acne-causing factor Propionibacterium acnes, and reduces sebum peroxidation by rationally disposing succinic acid, total asiaticosides and Norway spruce leaf extract. The inflammation and immune response caused by the product and Propionibacterium acnes can alleviate the abnormal keratinization of the pilosebaceous gland duct; help metabolize the abnormal keratinized cells, dredge the pores, and effectively promote the rapid removal of acne and acne through the synergistic effect of the three components.

2) The present invention can significantly reduce the irritation of succinic acid to the skin through the joint action of asiaticosides and Norwegian cloud mountain leaf extract, so that the prepared acne-removing composition has mildness at the same time.

Detailed ways

The present invention will be described in detail below in conjunction with specific embodiments. The following examples will help those skilled in the art to further understand the present invention, but do not limit the present invention in any form. It should be noted that those skilled in the art can make several modifications and improvements without departing from the concept of the present invention. These all belong to the protection scope of the present invention.

The words "preferred", "preferably", "more preferred", etc. herein refer to embodiments of the invention which may afford certain advantages, under certain circumstances. However, other embodiments may also be preferred, under the same or other circumstances. Furthermore, the recitation of one or more preferred embodiments does not imply that other embodiments are not useful, nor is it intended to exclude other embodiments from the scope of the invention.

It should be understood that, except in any operative example, or where otherwise indicated, all numbers expressing amounts of ingredients such as used in the specification and claims are to be understood as modified in all instances by the term "about". Accordingly, unless indicated to the contrary, the numerical parameters set forth in the following specification and attached claims are approximations that will vary depending upon the desired properties sought to be obtained by the present invention. At the very least, and not as an attempt to limit the application of the doctrine of equivalents to the scope of the claims, each numerical parameter should at least be construed in light of the number of reported significant digits and by applying ordinary rounding techniques.

Notwithstanding that the numerical ranges and parameters setting forth the broad scope of the invention are approximations, the numerical values set forth in the specific examples are reported as precisely as possible. Any numerical value, however, inherently contains certain errors necessarily resulting from the standard deviation found in their respective testing measurements.

The following examples provide a mild acne-removing composition, comprising the following components in parts by weight:

1-5 parts of succinic acid,

Centella asiaticoside 0.05-0.5 parts,

Norway spruce leaf extract 5-25 parts.

The succinic acid adopted in the present invention is a kind of postbiotic, has another name called succinic acid, and can be used as preservative, pH regulator, cosolvent; it can also be used to synthesize antidote, diuretic, sedative, hemostatic, synthetic antibiotic And vitamin A, vitamin B and so on. Succinic acid is also a good surfactant, which is a component of detergents, soaps and demulsifiers; it can also produce depilatory agents, toothpaste, cleaning agents, and high-efficiency wrinkle-removing beauty esters. Studies in recent years have also found that succinic acid can inhibit the activity of acne-causing factor Propionibacterium acnes. However, because succinic acid has a certain stimulating effect on the skin and mucous membranes, it is rarely added in existing skin care products.

The total asiatica glycosides used in the present invention is the total glycosides processed from the whole herb of Centella asiatica (L.) Urb., containing >50% madecassoside, and has anti-inflammatory properties. Sexual effect, can inhibit the skin inflammatory response induced by Propionibacterium acnes, slow down the abnormal keratinization of the pilosebaceous duct, promote the expression of collagen, and maintain the stability of the skin.

The Norway spruce (PICEA EXCELSA) leaf extract used in the present invention has a high proportion of monoterpenes, especially pine terpene, which can relieve pain, reduce inflammation and calm, inhibit inflammatory cytokines, and make the skin stronger and less susceptible to environmental influences , relieve redness, enhance skin barrier function. In addition, Norway spruce leaf extract acts as an antioxidant, reacting with free radicals and reducing free radical damage to cells.

SA 130；积雪草总苷购自Givaudan France SAS公司，商品名为CENTEROX，其各成分及含量分别为：羟基积雪草甙＞50％，积雪草苷10-24.99％，积雪草叶提取物25-49.99％；挪威云杉叶提取物购自NORTURE LIGHTS CELL SCIENCE INC.公司，商品名为NorLight B01。The raw material components used in the following examples are all commercially available raw materials, and succinic acid is purchased from ROQUETTE FRERES company, and the trade name is BEAUTE BY

SA 130; total asiaticosides are purchased from Givaudan France SAS company, trade name is CENTEROX, its components and contents are respectively: madecassoside > 50%, asiaticoside 10-24.99%, centella asiaticoside Extract 25-49.99%; Norway spruce leaf extract purchased from NORTURE LIGHTS CELL SCIENCE INC. company, trade name is NorLight B01.

Example 1

This example provides a mild acne-removing composition, including succinic acid, asiaticoside, and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 1.

Example 2

This example provides a mild acne-removing composition, including succinic acid, asiaticoside, and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 1.

Example 3

This example provides a mild acne-removing composition, including succinic acid, asiaticoside, and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 1.

Table 1

Comparative example 1

This comparative example provides an acne-removing composition, including asiaticosides and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 2. Compared with Example 1, only succinic acid is not added .

Comparative example 2

This comparative example provides an acne-removing composition, including succinic acid and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 2. Compared with Example 1, only asiaticoside is not added .

Comparative example 3

This comparative example provides an acne-removing composition, including succinic acid and asiaticoside, and the parts by weight of each component are shown in Table 2. Compared with Example 1, only Norway spruce leaf extract is not added .

Comparative example 4

This comparative example provides a kind of anti-acne composition, including succinic acid, asiaticoside and Norway spruce leaf extract, the parts by weight of each component are as shown in table 2, compared with embodiment 2, only increase parts by weight of succinic acid.

Comparative example 5

This comparative example provides an acne-removing composition, including succinic acid, asiaticoside and Norway spruce leaf extract, the parts by weight of each component are as shown in Table 2, compared with Example 2, only reduced The parts by weight of Norway spruce leaf extract.

Comparative example 6

This comparative example provides an acne-removing composition, including salicylic acid, asiaticoside and Norway spruce leaf extract, and the parts by weight of each component are shown in Table 2. Compared with Example 1, only Replace succinic acid with salicylic acid.

Table 2

Efficacy verification:

1. Antibacterial test

In order to verify the antibacterial effect of the antiacne composition of the present invention, refer to QB/T2738-2012 "Evaluation Method for Antibacterial and Antibacterial Effect of Daily Chemical Products" 7.3 "Bacteriostatic Effect Test Method of Antibacterial Type Daily Chemical Products ( Suspension Quantitative Method) " carry out bacteriostasis determination to antiacne composition described in the embodiment of the present invention 1-4 and comparative example 1-6, specifically as follows:

1) Test samples: After weighing the raw material components of Examples 1-4 and Comparative Examples 1-6 in parts by weight, add them to deionized water for dissolution, add water to make up to 100 parts, mix and stir evenly, and obtain each testing sample. Among them, the comparative example

2) Experimental bacteria: Propionibacterium acnes (GDMCC1.243)

3) Bacteriostasis effect: Each test sample is used to act on the test substance for 2 hours, and the test is repeated 3 times to get the average value.

See Table 3 for the test results of the antibacterial effect of the test samples prepared from the compositions of Examples 1-4 and Comparative Examples 1-3 on Propionibacterium acnes.

Table 3 to the test result of the antibacterial effect of Propionibacterium acnes

As can be seen from the results in table 3, examples 1-3 and comparative examples 2, 3, and 5 all have very strong bacteriostasis to Propionibacterium acnes, while the bacteriostasis of comparative example 1 is significantly worse than other test samples. Ratio 4 and 6 could not be tested because they could not be completely dissolved. It shows that the composition of the present invention has a very obvious effect of inhibiting Propionibacterium acnes after adding a specific content of succinic acid. However, if the content of succinic acid is too high, it will not be completely dissolved in deionized water, so that the sample to be tested cannot be prepared. Furthermore, if salicylic acid is used instead of succinic acid for the composition formulation of the present invention, salicylic acid can hardly be dissolved in deionized water, so that the sample to be tested cannot be prepared.

2. Acne-removing efficacy evaluation and mildness evaluation

1) Test sample: the anti-acne composition prepared in Examples 1-4 and Comparative Examples 1-6 was prepared into an anti-acne essence according to the formula shown in Table 4 below.

Table 4 Composition and parts by weight prepared by anti-acne essence

In table 4, NAOH is used to adjust the formula pH to 3.5-4.2 (wherein embodiment 1-3 and comparative example 1-3, comparative example 5 can adjust pH to 3.5-4 by adding a small amount of NAOH; comparative example 4 is due to the addition of succinic acid A larger amount needs to add a larger amount of NAOH to help succinic acid dissolve, and adjust the pH to 4.2), EDTA-2Na is used to improve the stability of the formula, glycerin, butylene glycol, and DC2501WAX are used as necessary humectants, and Diutan Gum is used to thicken , p-hydroxyacetophenone and 1,2-hexanediol are used for formula preservation.

When preparing the comparative example 6, it is necessary to add a large amount of NAOH to help the dissolution of salicylic acid, but the added amount makes the pH of the prepared acne essence as high as 12.9, which has exceeded the pH range allowed by normal skin care products, so The acne-removing essence of Comparative Example 6 was not subjected to subsequent test experiments.

The concrete preparation method of above-mentioned each anti-acne essence is as follows:

1. Weigh the corresponding deionized water;

2. Weigh EDTA-2Na, glycerin, butanediol, DC2501WAX, Diutan Gum, p-hydroxyacetophenone, and 1,2-hexanediol into water, heat to 70°C, stir and disperse evenly;

3. Cool down to 45°C, add succinic acid, salicylic acid, asiaticoside, Norway spruce leaf extract, NAOH, and stir to mix evenly;

4. Let it cool down to room temperature.

2) Volunteer

84 volunteers with acne were recruited. All the volunteers were healthy men and women aged 19-45, with facial acne, and the facial acne grade was 1-2 grades observed by the staff, and they had not used acne-removing products recently.

3) Test method: Volunteers were divided into 7 groups with 9-13 people/group. After morning and evening cleansing and lotion, the volunteers in each group took an appropriate amount of anti-acne essence corresponding to the corresponding group and applied it on the acne, and continued to use skin care products after it dried slightly. Use the anti-acne essence once in the morning and evening, and track the total effective rate and mildness of anti-acne through the questionnaire for 7 days and 14 days after use.

This experiment adopts the research method of self-control before and after. The subjects subjectively evaluate the product to help reduce acne, and the degree of recognition of the mild and non-irritating feeling when using the product, and give feedback by filling out the survey questionnaire.

4) Effect standard

The acne-removing effect was judged by the reduction rate of skin lesions. Healed: the reduction rate of skin lesions ≥ 90%; markedly effective: the reduction rate of skin lesions is 60% to 89%; effective: the reduction rate of skin lesions is 20% to 59%; ineffective: the reduction rate of skin lesions is <20% or aggravated.

Total effective rate = recovery rate + marked rate + effective rate.

The degree of mildness is judged by the degree of recognition of "feeling mild and non-irritating when used". The degree of approval adopts a 5-point scale, with 1 being strongly disagreed, 2 being disapproved, 3 being uncertain, 4 being agreeable, and 5 being very agreeable. Calculate the proportion of volunteers who choose "Very Approved" and "Approved" as the effective number, and obtain the Moderate Approval Rate.

Moderate approval rate = ("very approved" number + "approved" number)/total number

5) Test results

Table 5 shows the test results of anti-acne efficacy evaluation and mildness evaluation.

Table 5 Acne removal and mildness evaluation results

As can be seen from the results in Table 5, Example 1 is compared with Comparative Example 1, because Comparative Example 1 does not add succinic acid, so the mildness approval rate is 100% at 7 days and 14 days, but 7 days and 14 days of Comparative Example 1 The 14-day total effective rate is significantly worse than that of Example 1; it is illustrated that in Example 1, by adding succinic acid, although the approval rate of its mildness is reduced, it still reaches 91%, still has good mildness, and obviously Improves acne removal effect. Compared with Example 1 and Comparative Example 2, because Comparative Example 2 does not add asiaticoside, its 7 days and 14 days compared with Example 1, the total effective rate and the mildness approval rate all significantly decrease; illustrate Example 1 By adding asiaticosides in the composition, the anti-acne effect and mildness of the composition can be improved at the same time. Compared with Example 1 and Comparative Example 3, because Comparative Example 3 did not add Norway spruce leaf extract, it compared the 7 days and 14 days total effective rate of Example 1 to the same effect, but the 7 days and 14 days of Comparative Example 3 The approval rate of weather and temperature is significantly lower than that in Example 1; it shows that in Example 1, the mildness can be obviously improved by adding the Norway spruce leaf extract. From the comparative results of the above-mentioned Example 1 and Comparative Examples 1-3, it can be known that succinic acid, asiaticoside and Norway spruce leaf extract have obvious synergistic effects, and after their combination, mildness (14 days mildness) can be obtained. The composition has the degree of approval rate up to 90-100%) and the anti-acne effect (the total effective rate reaches 58.3-70% within 14 days).

It can also be seen from the results in Table 5 that compared with Comparative Example 4 in Example 2, Comparative Example 4 further increased the amount of succinic acid, but did not make its effect improve. On the contrary, it compared the 7 days and The 14-day total effective rate and mildness approval rate all decreased significantly; it shows that if the content of succinic acid in Example 2 is too high, it will lead to a significant decline in mildness and acne-removing efficacy. Compared with comparative example 5 in embodiment 2, the content of Norway spruce leaf extract was reduced in comparative example 5, and its total effective rate and mild degree approval rate all significantly decreased compared with 7 days and 14 days of embodiment 2; illustrate If the Norway spruce leaf extract in Example 2 is too low, it will also cause a significant decline in mildness and anti-acne efficacy. From the comparative results of Example 2 and Comparative Examples 4-5 above, it can be seen that the mildness and anti-acne effect of the composition can be improved at the same time only when the specific content ranges of succinic acid and Norway cloud mountain leaf extract are used.

There are many specific application ways of the present invention, and the above descriptions are only preferred embodiments of the present invention. It should be noted that the above embodiments are only used to illustrate the present invention, but not to limit the protection scope of the present invention. For those skilled in the art, some improvements can be made without departing from the principle of the present invention, and these improvements should also be regarded as the protection scope of the present invention.

Claims (10)

1. a gentle acne-removing composition, is characterized in that, comprises each component of following weight portion: 1-5 parts of succinic acid, Centella asiaticoside 0.05-0.5 parts, Norway spruce leaf extract 5-25 parts. 2. The gentle anti-acne composition according to claim 1, characterized in that, comprising the following components by weight: 5 parts of succinic acid, Centella asiaticoside 0.5 part, Norway spruce leaf extract 5 parts. 3. The gentle anti-acne composition according to claim 1, characterized in that, comprising the following components by weight: 1 part succinic acid, Centella asiaticoside 0.05 part, Norway spruce leaf extract 25 parts. 4. The mild anti-acne composition according to any one of claims 1-3, characterized in that the total asiaticoside comprises madecassoside in a weight ratio greater than 50%. 5. The mild acne-removing composition according to any one of claim 4, characterized in that, said asiaticoside also comprises 10-24.99% asiaticoside and 25-49.99% asiaticoside by weight Centella Asiatica Leaf Extract. 6. An application of the mild acne-removing composition according to any one of claims 1-5 in the preparation of skin care products. 7. The application according to claim 6, wherein the dosage form of the skin care product is any one of cream, lotion, water, essence, facial mask, gel, base makeup, spray and cleansing products. 8. The application according to claim 7, characterized in that the addition amount of the acne-removing composition in skin care products is 6.05-30.5%. 9. An anti-acne essence, characterized in that it comprises the mild anti-acne composition of any one of claims 1-5, and also includes a pH regulator, a stabilizing agent, a moisturizing agent, a thickener, and a preservative at least one of the 10. The anti-acne essence according to claim 9, further comprising other functional ingredients.