CN1163094A - Preparing technology for changing coral into hydroxy apatite - Google Patents
Preparing technology for changing coral into hydroxy apatite Download PDFInfo
- Publication number
- CN1163094A CN1163094A CN 96119175 CN96119175A CN1163094A CN 1163094 A CN1163094 A CN 1163094A CN 96119175 CN96119175 CN 96119175 CN 96119175 A CN96119175 A CN 96119175A CN 1163094 A CN1163094 A CN 1163094A
- Authority
- CN
- China
- Prior art keywords
- coral
- corallium japonicum
- changing
- japonicum kishinouye
- artificial bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229910052588 hydroxylapatite Inorganic materials 0.000 title claims description 10
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 title claims description 10
- 235000014653 Carica parviflora Nutrition 0.000 title abstract 3
- 241000243321 Cnidaria Species 0.000 title abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- 239000012153 distilled water Substances 0.000 claims abstract description 4
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 3
- 238000006243 chemical reaction Methods 0.000 claims abstract description 3
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims abstract description 3
- 239000010452 phosphate Substances 0.000 claims abstract description 3
- 210000000988 bone and bone Anatomy 0.000 claims description 13
- 241001450685 Corallium japonicum Species 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 238000002360 preparation method Methods 0.000 claims description 5
- 239000005696 Diammonium phosphate Substances 0.000 claims description 4
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 claims description 4
- 229910000388 diammonium phosphate Inorganic materials 0.000 claims description 4
- 235000019838 diammonium phosphate Nutrition 0.000 claims description 4
- 238000001035 drying Methods 0.000 claims description 4
- 239000007789 gas Substances 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 206010013786 Dry skin Diseases 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 238000002791 soaking Methods 0.000 claims description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract description 3
- 238000000034 method Methods 0.000 abstract description 3
- 244000132059 Carica parviflora Species 0.000 abstract 1
- 238000004090 dissolution Methods 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 230000035484 reaction time Effects 0.000 abstract 1
- 239000000463 material Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 230000018044 dehydration Effects 0.000 description 1
- 238000006297 dehydration reaction Methods 0.000 description 1
- 238000000921 elemental analysis Methods 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 230000002706 hydrostatic effect Effects 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000004062 sedimentation Methods 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Landscapes
- Materials For Medical Uses (AREA)
Abstract
Coral is soaked with 10-20% concentration phosphate solution, and after reaction for 68 hr at 1-300 Kg/sq cm pressure and 250 deg.C temp, the coral is washed with distilled water at 100 deg.C until no inorganic salt component, dewatered, dried at 100 deg.C and high temp and gas disinfected. The said process is performed at medium and low pressure condition and needs only short reaction time, and its product has low dissolution speed in acid medium, high quality and low cost.
Description
The present invention relates to a kind of preparation technology who Corallium Japonicum Kishinouye is changed into hydroxy-apatite ' artificial bone '.
" artificial bone " that hydroxyapatite is made has excellent biological compatibility and bone affinity.With reagent hydroxyapatite hydrostatic profile, " artificial bone " that high temperature sintering is made used in the damaged operation of bone of some not subjected to pressure power.But the material of this type is subjected to certain limitation in the foaming sintering process, and artificial bone requires that certain sedimentation is arranged, and in order to the growth of blood vessel and tissue, but intensity then is subjected to certain limitation, moreover their network structure does not interconnect.The characteristics that the foreign scholar utilizes Corallium Japonicum Kishinouye to have special loose structure and hole evenly to communicate through the processing of certain program, are made artificial bone and are used.But the composition of Corallium Japonicum Kishinouye is CaCO
3, meet acid medium and decompose easily, so when implanting in the animal body, very fast degraded is not exclusively repaired defective region.They further carry out chemical treatment with Corallium Japonicum Kishinouye, with CaCO
3Composition becomes hydroxyapatite, makes it have porous concurrently and is easy to bio-compatible, the advantage that biodegradation rate is slow.Be made into " artificial bone " material, obviously be better than " artificial bone " made with the reagent hydroxyapatite.But CaCO with Corallium Japonicum Kishinouye
3Composition changes the composition of hydroxyapatite into, and their loose structure keeps again, and is then very complicated aspect process conditions.
This purpose be to provide the preparation technology who Corallium Japonicum Kishinouye is changed into hydroxy-apatite ' artificial bone ' that a kind of preparation technology is simple, the equipment needed thereby adult is low.
The present invention is achieved in that and is made into 10%～20% solution soaking Corallium Japonicum Kishinouye with phosphate (as diammonium phosphate, sodium hydrogen phosphate etc.), at 1kg/cm
2～300kg/cm
2The following 250 ℃ of reactions of pressure 48～68 hours, with distilled water 100 ℃ of following washings to there not being the organic salt composition, dewater 100 ℃ of dryings, high temperature and gas depoisonings.
Below in conjunction with embodiment the present invention is described in detail.
Embodiment one: get 10%～20% diammonium phosphate, disodium phosphate soln 50ml and 20 gram Corallium Japonicum Kishinouyes mix, with nitrogen pressure to 100kg/cm
2, being heated to 250 ℃, constant temperature 68 hours takes out, and washs 10 times each water 100ml for 100 ℃ down with distilled water.Dehydration, drying, high temperature (120 ℃) and gas depoisoning.
Embodiment two: get 10%～20% diammonium phosphate, Ammonia 50ml and 20 gram Corallium Japonicum Kishinouyes mix 1kg/cm
2Be heated to 250 ℃ under the pressure, constant temperature 48 hours, washing, drying, all the other are with executing example one.
The product that makes with this technology can be made " ocular prosthesis seat " and the sheet material of all kinds of " artificial bones " of all size.
Technology of the present invention has following advantage:
1. this technology can be carried out under the press strip spare in low, reacts needed time shorten, and makes The end product quality height that gets, price is low.
2. with this technology CO
3 2-Replacement ratio is more complete, and products obtained therefrom dissolves in acid medium slowly, and the hydroxyl characteristic peak is obvious, the results of elemental analyses zero difference.
Claims (1)
1. one kind changes Corallium Japonicum Kishinouye the preparation technology of hydroxy-apatite ' artificial bone ' into, it is characterized in that: be made into 10%～20% solution soaking Corallium Japonicum Kishinouye with phosphate (receiving etc. as diammonium phosphate, phosphoric acid hydrogen two), at 1kg/cm
2～300kg/cm
2The following 250 ℃ of reactions of pressure 48～68 hours, with distilled water 100 ℃ of following washings to there not being the organic salt composition, dewater 100 ℃ of dryings, high temperature and gas depoisonings.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119175 CN1163094A (en) | 1996-10-25 | 1996-10-25 | Preparing technology for changing coral into hydroxy apatite |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 96119175 CN1163094A (en) | 1996-10-25 | 1996-10-25 | Preparing technology for changing coral into hydroxy apatite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1163094A true CN1163094A (en) | 1997-10-29 |
Family
ID=5125625
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 96119175 Pending CN1163094A (en) | 1996-10-25 | 1996-10-25 | Preparing technology for changing coral into hydroxy apatite |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1163094A (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069614C (en) * | 1998-05-16 | 2001-08-15 | 冯守华 | Chemical hole-enlarging technology for natural coral hydroxyl apatite material |
| WO2002040398A1 (en) * | 2000-11-16 | 2002-05-23 | University Of Technology, Sydney | Processes for treating coral and coating an object |
| CN101843919A (en) * | 2010-05-31 | 2010-09-29 | 哈尔滨师范大学 | Method for preparing hydroxyapatite/composite hole bioactive glass |
-
1996
- 1996-10-25 CN CN 96119175 patent/CN1163094A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1069614C (en) * | 1998-05-16 | 2001-08-15 | 冯守华 | Chemical hole-enlarging technology for natural coral hydroxyl apatite material |
| WO2002040398A1 (en) * | 2000-11-16 | 2002-05-23 | University Of Technology, Sydney | Processes for treating coral and coating an object |
| CN101843919A (en) * | 2010-05-31 | 2010-09-29 | 哈尔滨师范大学 | Method for preparing hydroxyapatite/composite hole bioactive glass |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
| WD01 | Invention patent application deemed withdrawn after publication |