CN116265007A - Anti-drop oil-control and soothing essence and preparation method thereof - Google Patents

Abstract

The invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further relates to an anti-drop oil-control and soothing essence and a preparation method thereof. The raw materials comprise, by weight: 1-10% of humectant, 0.9-8% of plant extract A, 0.05-5% of plant extract B, 0.2-3% of antibacterial agent, 0.005-3% of vitamin, 0.005-2% of skin conditioner, 0.1-1% of pH regulator, 0.001-5% of hydrolyzed yeast protein, 0.05-0.5% of thickener and the balance of deionized water; preferably, the raw materials also comprise 5-30% ethanol, 0.5-10% isododecane or 0.5-5% PEG-40 hydrogenated castor oil, 0.1-1% preservative and 0.1-0.5% essence. The anti-drop oil-control and soothing essence can effectively reduce sebum production and inhibit malassezia propagation.

Description

A kind of anti-dandruff control oil soothing essence and preparation method thereof

technical field

The invention relates to the technical field of skin care products, in particular to the field of IPC A61K8, and further relates to an anti-dandruff control oil soothing essence and a preparation method thereof.

Background technique

With the development of society, people's daily life, stress level and eating habits have undergone tremendous changes. The number of people with hair loss has increased sharply and is becoming younger, which has brought great impact on people's physical and mental health. Hair loss can negatively affect people's self-confidence and self-esteem, which can affect mental health and even life status.

The sebaceous glands can secrete sebum, which can protect the hair, lock the moisture in the skin, and block some external fungi and sundries. However, when the scalp oil is secreted in large quantities, the excess lipid secreted by the scalp will cause Malassezia to multiply. The lipase and phospholipase secreted by Malassezia will hydrolyze the triacylglycerol in the skin, releasing oleic acid and arachidonic acid Unsaturated fatty acids such as acid can destroy the barrier function of the stratum corneum of the epidermis, and induce keratinocytes to produce pro-inflammatory cytokines such as IL-1, IL-2, IL-4, IL-6, IFN-γ, TNF-α, etc., causing skin Inflammatory Response and Desquamation Inflammation eventually destroys the hair follicles and the skin of the scalp around the follicles, leading to hair loss.

Chinese patent CN 112107527 A discloses an anti-stripping essence and its preparation method. Its raw materials include alcohols, plant extracts, hydrogenated castor oil, thickeners, sodium hyaluronate, peptides and water; this invention provides The anti-hair loss essence can meet the needs of preventing hair loss and promoting hair growth at the same time, and its active ingredients are not easy to be washed off, less irritating to the scalp, can maintain a long-lasting fragrance, and have good storage stability at high temperatures. But its mechanism of action is single, and the anti-hair loss effect is not outstanding.

Chinese patent CN 114053190 A discloses an anti-hair loss essence and its preparation method. Its raw materials include ginseng extract, mugwort leaf extract, peony root extract, watercress extract, PCA zinc, nicotinamide, ethanol, propylene glycol and /or glycerin and deionized water. The added amount of active ingredients in the anti-hair loss essence of this invention is small, and the active ingredients are easily washed off, and high concentration of ethanol is added, which is very irritating to the scalp.

Contents of the invention

In order to solve the above problems, the first aspect of the present invention provides a kind of anti-shedding oil control soothing essence, and its raw materials include: 1-10% moisturizing agent, 0.9-8% plant extract A, 0.05-5% Plant extract B, 0.2-3% antibacterial agent, 0.005-3% vitamin, 0.005-2% skin conditioner, 0.1-1% pH regulator, 0.001-5% hydrolyzed yeast protein, 0.05-0.5% thickener, The balance of deionized water;

Preferably, its raw materials also include 5-30% ethanol, 0.5-10% isododecane or 0.5-5% PEG-40 hydrogenated castor oil, 0.1-1% preservatives, and 0.1-0.5% essence.

The function of the moisturizer is to form a water-locking protective film on the scalp, help the stratum corneum of the skin to store water, and maintain the normal cell metabolism of the skin.

In some preferred embodiments, the moisturizing agent is selected from one or more combinations of 1,2-hexanediol, 1,3-propanediol, glycerin, caprylyl glycol, sodium hyaluronate, and trehalose.

In some preferred embodiments, the moisturizing agent is 1,2-hexanediol, 1,3-propylene glycol, caprylyl glycol and sodium hyaluronate; the molecular weight of the sodium hyaluronate is 200kDa～400kDa; the 1 , the weight ratio of 2-hexanediol, 1,3-propylene glycol, caprylyl glycol and sodium hyaluronate is (0.1-1):(0.5-3):(0.025-0.5):(0.005-0.1); the applicant Surprisingly, when 1,2-hexanediol, 1,3-propanediol, caprylyl glycol and sodium hyaluronate are selected as the moisturizer, it can not only improve the moisturizing effect of the anti-aging oil control soothing essence, but also improve the anti-aging effect. The stability of oil-free soothing serum. The applicant speculates that: 1,2-hexanediol, 1,3-propanediol, caprylyl glycol and sodium hyaluronate can work together with ethanol to promote the essence to form a stable system; in addition, sodium hyaluronate with a specific molecular weight can be used in A transparent hydration film is formed on the surface of the scalp, which not only reduces the irritation of ethanol to the scalp, but also ensures that the active ingredients in various plant extracts are not easily washed away.

The active ingredients in plant extracts are relatively safe, effective, and easy to use for the treatment and prevention of hair loss. In some preferred embodiments, the plant extract A is selected from Sophora Flavescens extract, Panax Ginseng C.A.Mey extract, Arctium Lappa L Extract, Ginger Root (Zingiber Officinale) Extract, Red Clover (Trifolium Pratense) Leaf Extract, Artemisia Argyi (Artemisia Argyi) Leaf Extract, Forsythia Suspensa (Forsythia Suspensa) Extract, Peony (Paeonia Suffruticosa Andr.) Root Extract 1. One or more combinations of Polygonum multiflora (Fallopia Multiflora (Thunb.) Harald.) root extract.

In some preferred embodiments, the plant extracts include sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract and mugwort leaf extract.

In some preferred embodiments, the weight ratio of the Sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract, and Artemisia argyi leaf extract is (0.1 -2):(0.01-2):(0.05-1):(0.1-0.6):(0.03-0.18):(0.005-0.03):(0.005-0.03).

Sophora flavescens root extract contains a type II 5α-reductase inhibitor, which can reduce the accumulation of dihydrotestosterone in the scalp, thereby reducing hair loss, increasing the expression of dermal papilla growth factor, and promoting hair growth.

Ginseng extract contains a variety of saponins and polysaccharides, without any adverse stimulation to the scalp, can expand scalp capillaries, promote scalp blood circulation, increase scalp nutrition, adjust the water and oil balance of the scalp; promote hair follicle vitality, improve hair toughness, reduce hair loss and hair breakage; ginseng extract can also inhibit the activity of 5α-reductase, reduce the content of dihydrotestosterone in skin tissue, and promote hair growth.

The active ingredients in burdock extract can reduce the levels of inflammatory cytokines and IL-6 and TNF-α; by inhibiting the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signal transduction pathway and IL-1β, The production of IL-6 and monocyte chemoattractant protein 1 (MCP-1) to inhibit the expression of inducible NO synthase (iNOS), thereby playing an anti-inflammatory effect; polyphenols chlorogenic acid in burdock extract Can effectively inhibit Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Micrococcus luteus.

The flavonoids in the extract of oriental cypress leaves can activate hair mother cells and promote blood circulation, revive the hair follicles with declining hair growth ability and promote blood circulation to supplement nutrients to play the role of hair nourishment and hair growth; It can inhibit the activity of 5a-reductase and act on sebocytes, thereby reducing the production of sebum; in addition, the extract of oriental cypress leaves can also inhibit the speed of degeneration of hair epidermal cells, delay shedding, reduce the occurrence of seborrheic skin diseases, and achieve anti-dandruff Antipruritic effect.

Ginger root is the fresh rhizome of ginger (Zingier offcinale Roscoe), a plant belonging to Zingiberaceae Zingiberaceae, and its chemical composition generally contains several types such as volatile oil, gingerol, diphenylheptane, and flavonoids. Ginger is a traditional Chinese medicine commonly used in folks to treat hair loss. Ginger is oily and pungent, which can accelerate skin blood circulation, promote scalp metabolism, and activate hair follicle tissue.

Red clover leaf extract has a bactericidal effect, and has a good inhibitory effect on dandruff bacillus, and can be used to inhibit the secretion of scalp oil.

Artemisia argyi leaf extract has good antibacterial and anti-allergic effects, and can effectively improve hair loss problems caused by scalp mites and bacterial infections.

The present invention can effectively inhibit scalp oil production through the joint action of sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract, mugwort leaf extract and hydrolyzed yeast protein. Secretion, regulate the water-oil balance of the scalp; reduce the accumulation of dihydrotestosterone in the scalp, thereby reducing hair loss, increase the expression of dermal papilla growth factor, and promote hair growth; expand scalp capillaries, promote scalp blood circulation, and make hair growth decline hair follicle revival; further investigation found that when the weight ratio of Sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract, and Artemisia argyi leaf extract is (0.1- 2): (0.01-2): (0.05-1): (0.1-0.6): (0.03-0.18): (0.005-0.03): (0.005-0.03), the stability of the anti-shedding oil control soothing essence is prepared Sex is better.

In order to improve the soothing effect of the anti-dripping and oil-controlling soothing essence, and alleviate the stimulating effect of ethanol on the scalp, in some preferred embodiments, the plant extract B includes olive (Olea Europaea) fruit oil, seabuckthorn (Hippophae Rhamnoides) seed oil, cherry blossom (Prunus Speciosa) oil, lavender (Lavandula Angustifolia) oil, menthol (Mentha Canadaensis L), jasmine (Jasminum Sambac) oil, rose flower (Rosa Rugosa) oil, perilla (Perilla Frutescens) leaf oil or multiple combinations.

In some preferred embodiments, the plant extract B includes olive oil, sea buckthorn seed oil, cherry blossom oil, lavender oil and menthol; the olive oil, sea buckthorn seed oil, cherry blossom oil, lavender oil, menthol The weight ratio is (0.1-1):(0.1-1):(0.05-0.4):(0.005-0.5):(0.05-0.5). Among them, olive fruit oil promotes blood circulation and hair growth; high-quality fatty acids rich in seabuckthorn seed oil also play an important role in accelerating hair regeneration; cherry blossom oil can balance scalp oil, control oil and eliminate acne; lavender oil can promote blood circulation in the scalp circulation, helps to control hair loss and promote hair growth; menthol can promote the proliferation of hair follicle keratinocytes and dermal papilla cells, and rejuvenate the scalp; in addition, menthol also has a bactericidal effect, which can help fight dandruff.

In order to inhibit the growth of Malassezia on the surface of the scalp and reduce the generation of dandruff, in some preferred embodiments, the antibacterial agent is selected from dipotassium glycyrrhizinate, ethylhexylglycerin, piroctone olamine salt, chlorine One or more combinations of hexidine, zinc pyrithione, campanola, and ketoconazole; preferably, the antibacterial agent includes dipotassium glycyrrhizinate, ethylhexylglycerin, and piroctone olamine salt.

In some preferred embodiments, the weight ratio of dipotassium glycyrrhizinate, ethylhexylglycerin and piroctone olamine salt is (0.1-1):(0.1-0.5):(0.05-1).

Dipotassium glycyrrhizinate has antibacterial effect on Staphylococcus aureus, Staphylococcus albus, Escherichia coli, Shigella flexneri, Salmonella paratyphi B and other bacteria, and it also has strong antioxidant activity ; Ethylhexylglycerin can inhibit the growth and reproduction of odor-causing bacteria without affecting the beneficial skin flora; in addition, it can enhance the efficacy of the preservative phenoxyethanol; piroctone olamine salt can effectively inhibit malaria Chromobacteria can also reduce scalp inflammation.

The vitamin plays an important role in normal hair follicle development and immune cell function. In order to improve the anti-dripping and oil-controlling effect of the soothing essence, in some preferred embodiments, the vitamin is selected from one or more combinations of panthenol, biotin, vitamin E, vitamin A, and vitamin D. Preferably, the vitamins include panthenol, biotin and vitamin E.

In some preferred embodiments, the weight ratio of panthenol, biotin and vitamin E is (0.1-1):(0.0005-0.1):(0.1-1).

Panthenol can penetrate the hair shaft and the root of the hair, and is quickly reduced to vitamin B5 under the action of enzymes, thus providing additional B vitamins to the hair, helping to thicken the hair and promote hair growth.

Biotin, also known as vitamin H and coenzyme R, is a water-soluble vitamin and also belongs to the vitamin B family, B7. It is a necessary substance for the synthesis of vitamin C and is indispensable for the normal metabolism of fat and protein. Biotin can promote hair growth and scalp metabolism, make hair appear natural luster, inhibit scalp oil secretion, and reduce hair fall.

Vitamin E can resist hair aging, promote hair mother cell division, make hair grow and reduce hair fall.

In some preferred embodiments, the skin conditioning agent is selected from one or more combinations of arginine, zinc gluconate, nicotinamide, and bisabolol; preferably, the skin conditioning agent includes amino acid and bisabolol.

In some preferred embodiments, the weight ratio of arginine to bisabolol is (0.005-0.5): (0.05-0.3).

Nitrogen oxides are needed for hair growth. Arginine can participate in the production of nitrogen compounds. In addition, it can expand the blood vessels in the scalp and increase the amount of nutrients and oxygen delivered to the hair follicles; bisabolol has high permeability in the skin cortex. Dozens of times that of commonly used penetrating agents, it can promote the penetration of yeast protein and plant extracts into scalp hair follicles.

In some preferred embodiments, the pH regulator is selected from one or more combinations of sodium citrate, disodium hydrogen phosphate, and sodium dihydrogen phosphate; preferably, the pH regulator is sodium citrate.

In some preferred embodiments, the preservative is selected from one or more combinations of phenoxyethanol, p-hydroxyacetophenone, sodium benzoate, potassium sorbate, benzoic acid, and dehydroacetic acid; preferably, the The preservatives are phenoxyethanol and p-hydroxyacetophenone.

In some preferred embodiments, the weight ratio of phenoxyethanol to p-hydroxyacetophenone is (0.1-0.5):(0.1-1).

In order to improve the synergistic effect between hydrolyzed yeast protein and various plant extracts, in some preferred embodiments, the hydrolyzed yeast protein is selected from the hydrolyzate of Saccharomyces cerevisiae protein, which contains more than ten kinds of amino acids. The weight ratio of extract A to hydrolyzed yeast protein is (10-14):1.

Hydrolyzed yeast protein is the hydrolyzed product of yeast cells, which is obtained by autolysis or hydrolysis with external enzymes. Hydrolyzed yeast products contain a large amount of amino acids, small peptides, rich in B vitamins, glutathione and nucleotide substances. Compared with common yeast protein, hydrolyzed yeast protein has a smaller molecular weight and is easier to penetrate into the sebaceous glands, improving the problem of exuberant oil secretion in the scalp; in addition, hydrolyzed yeast protein and various plant extracts can also repair damaged hair follicle cells and promote hair growth. Hair follicle cells divide to maintain scalp hair follicle cell activity.

In order to improve the stability of the anti-dandruff control oil soothing essence, in some preferred embodiments, the weight ratio of the isododecane to the plant extract B is (2-5):1. Isododecane is a colorless, odorless, transparent liquid with good physical and chemical properties and toxicity, almost free of aromatics and sulfur, non-irritating to eyes and skin, non-sensitizing, and has no side effects on blackheads; this weight ratio The following plant extract B has excellent solubility and compatibility in isododecane, thereby improving the stability of the anti-dandruff control oil soothing essence.

In some preferred embodiments, the thickener is selected from any one of hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methyl cellulose, methyl cellulose, carboxymethyl cellulose .

The second aspect of the present invention provides a preparation method of anti-dandruff control oil soothing essence, which is prepared by mixing various raw materials uniformly according to weight percentage.

Beneficial effects: the anti-dripping and oil-controlling soothing essence of the present invention uses a variety of plant extracts combined with hydrolyzed yeast protein, vitamins, antibacterial agents and skin conditioners, which can effectively inhibit the activity of 5a-reductase and reduce the production of sebum; inhibit Malassezia Bacteria overgrowth, balance the micro-ecological environment of the scalp; expand scalp capillaries, promote scalp blood circulation, and promote hair follicle regeneration; the anti-dandruff control oil soothing essence of the present invention adopts a water-oil dual-phase system to retain both the water phase and the oil phase While improving the efficacy, it also improves the stability of the essence system.

Description of drawings

Fig. 1 is a test chart of the inhibition zone of the anti-shedding oil control soothing essence prepared in Example 2 of the present invention.

Detailed ways

Example 1

Embodiment 1 provides a kind of anti-dandruff control oil soothing essence, by weight percentage, its raw material comprises: 9% humectant, 6% plant extract A, 4% plant extract B, 2% antibacterial agent, 2% vitamin , 1% skin conditioning agent, 0.5% pH regulator, 0.5% hydrolyzed yeast protein, 0.5% preservative, 0.3% essence, 0.3% thickener, 20% ethanol, 8% isododecane, deionized water balance .

The moisturizing agent is 1,2-hexanediol (CAS No.: 6920-22-5), 1,3-propylene glycol (CAS No. 504-63-2), caprylyl glycol (CAS No.: 1117-86-8 ) and sodium hyaluronate; the molecular weight of the sodium hyaluronate is 200kDa ~ 400kDa, purchased from Bloomage Biotechnology Co., Ltd.; the 1,2-hexanediol, 1,3-propanediol, caprylyl glycol and transparent The weight ratio of sodium hyphenate is 1:3:0.5:0.1.

The plant extract A is Sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract and mugwort leaf extract; the Sophora flavescens extract, ginseng extract, burdock root extract, arborvitae leaf extract, ginger root extract, red clover leaf extract, Artemisia argyi leaf extract weight ratio is 2:2:1:0.6:0.18:0.03:0.03; Extract, ginseng extract, burdock root extract, and orientalis leaf extract were all purchased from Huzhou Huxing Daily Chemical Co., Ltd.; the ginger root extract, red clover leaf extract and mugwort leaf extract were all purchased from Shanghai Jiakai Biological Technology Co., Ltd.

The plant extract B includes olive oil, seabuckthorn seed oil, cherry blossom oil, lavender oil, and menthol; the weight ratio of the olive oil, seabuckthorn seed oil, cherry blossom oil, lavender oil, and menthol is 1:1: 0.3:0.4:0.4; the olive fruit oil and seabuckthorn seed oil were purchased from Vantage Specialty Chemicals, Inc.; the cherry blossom oil and lavender oil were purchased from Guangzhou Yueze Chemical Co., Ltd.; menthol was purchased from Anhui Yifan Perfume Co., Ltd. .

Described antibacterial agent is Dipotassium Glycyrrhizinate (CAS No.: 68797-35-3) and ethylhexylglycerin (CAS No.: 70445-33-9); The weight ratio of described Dipotassium Glycyrrhizinate and ethylhexylglycerin is 1:0.3.

The vitamins are panthenol, biotin and vitamin E; the weight ratio of the panthenol, biotin and vitamin E is 1:0.1:1; the panthenol and vitamin E are purchased from BASF (China) Co., Ltd.; the Biotin was purchased from DSM (China) Co., Ltd.

The skin conditioning agent includes arginine and bisabolol; the weight ratio of the arginine and bisabolol is 1:1; the arginine is purchased from Dezhixin Flavors and Fragrances (Nantong) Co., Ltd. ; The bisabolol was purchased from BASF (China) Co., Ltd.

The pH regulator is sodium citrate (CAS number: 68-04-2).

Described preservative is phenoxyethanol (CAS number: 122-99-6) and p-hydroxyacetophenone (CAS number: 99-93-4); The weight ratio of described phenoxyethanol and p-hydroxyacetophenone is 3:1.

The essence was purchased from Mingkang Flavor and Fragrance Co., Ltd.

The thickener is hydroxyethyl cellulose (CAS No.: 9004-62-0), purchased from Dow (Zhangjiagang) Investment Co., Ltd.

The isododecane (CAS No.: 31807-55-3) was purchased from Zibo Runfu Chemical Technology Co., Ltd.

The hydrolyzed yeast protein was purchased from Ashland (China) Investment Co., Ltd.

A preparation method of anti-dripping and oil-controlling soothing essence comprises the following steps:

(1) 1,2-hexanediol, 1,3-propanediol, caprylyl glycol, phenoxyethanol and p-hydroxyacetophenone, flavescens extract, ginseng extract, burdock root extract, and arborvitae leaf extract , ginger root extract, red clover leaf extract, mugwort leaf extract, dipotassium glycyrrhizinate, ethylhexylglycerin and hydrolyzed yeast protein are dissolved in ethanol and dispersed evenly, and set aside.

(2) Add hydroxyethyl cellulose to deionized water, heat to 70°C, add panthenol, biotin, sodium hyaluronate, vitamin E, sodium citrate, arginine, bisabolol and step (1) The obtained mixture was stirred evenly until a transparent aqueous phase was obtained.

(3) Dissolve olive fruit oil, seabuckthorn seed oil, cherry blossom oil, lavender oil, menthol and essence in isododecane, and stir until transparent to obtain an oil phase.

(4) The water phase obtained in step (2) and the oil phase obtained in step (3) are filled in proportion to obtain the product.

The filling volume ratio of the water phase and the oil phase in the step (4) is 2:1.

The prepared anti-dandruff control soothing essence liquid has an upper layer oil phase which is a yellow transparent liquid, and a lower layer water phase which is a light yellow transparent liquid.

Example 2

Embodiment 2 provides a kind of anti-dandruff control oil soothing essence, by weight percentage, its raw material comprises: 5% humectant, 4% plant extract A, 0.5% plant extract B, 2% antibacterial agent, 1.1% vitamin , 1.5% skin conditioning agent, 0.5% pH regulator, 3% hydrolyzed yeast protein, 0.6% preservative, 0.3% essence, 0.3% thickener, 20% ethanol, 5% PEG-40 hydrogenated castor oil, deionized water margin.

The humectant is 1,2-hexanediol (CAS No.: 6920-22-5), 1,3-propanediol (CAS No. 504-63-2) and caprylyl glycol (CAS No.: 1117-86-8 ) The weight ratio of 1,2-hexanediol, 1,3-propanediol and caprylyl glycol is 1:1:0.2.

The plant extract A is Sophora flavescens extract and cypress leaf extract; the weight ratio of flavescens extract and cypress leaf extract is 1:1; the flavescens extract and cypress leaf extract All were purchased from Huzhou Huxing Daily Chemical Co., Ltd.

The plant extract B is menthol; the menthol is purchased from Anhui Yifan Perfume Co., Ltd.

The antibacterial agent is Dipotassium Glycyrrhizinate (CAS No.: 68797-35-3), ethylhexylglycerin (CAS No.: 70445-33-9) and piroctone olamine salt; The weight ratio of hexylglycerin and piroctone olamine salt is 1:0.3:0.05; the piroctone olamine salt is purchased from Shanghai Huanqiu Industrial Development Co., Ltd.

The vitamins are panthenol and biotin; the weight ratio of the panthenol and biotin is 10:1; the panthenol is purchased from BASF (China) Co., Ltd.; the biotin is purchased from DSM (China) Co., Ltd. .

The skin conditioner includes zinc gluconate and nicotinamide; the weight ratio of zinc gluconate and nicotinamide is 2:1; the zinc gluconate is purchased from BASF (China) Co., Ltd.; the nicotinamide is purchased from Suzhou Lonza Chemical Co., Ltd.

The pH regulator is sodium citrate (CAS number: 68-04-2).

Described preservative is phenoxyethanol (CAS number: 122-99-6) and p-hydroxyacetophenone (CAS number: 99-93-4); The weight ratio of described phenoxyethanol and p-hydroxyacetophenone is 3:1.

The essence was purchased from Firmenich Fragrances (China) Co., Ltd.

The thickener is hydroxyethyl cellulose (CAS No.: 9004-62-0), purchased from Dow (Zhangjiagang) Investment Co., Ltd.

The PEG-40 hydrogenated castor oil was purchased from BASF (China) Co., Ltd.

The hydrolyzed yeast protein was purchased from Ashland (China) Investment Co., Ltd.

A preparation method of anti-dripping and oil-controlling soothing essence comprises the following steps:

(1) 1,2-hexanediol, 1,3-propanediol, caprylyl glycol, phenoxyethanol, p-hydroxyacetophenone, Sophora flavescens extract, cypress leaf extract, dipotassium glycyrrhizinate, ethyl Hexylglycerin, piroctone olamine salt and hydrolyzed yeast protein are dissolved in ethanol and dispersed evenly, and set aside.

(2) Add hydroxyethyl cellulose to deionized water, heat to 70°C, add panthenol, biotin, sodium citrate, zinc gluconate, nicotinamide, the mixture obtained in step (1), and menthol after completely dissolving , hydrogenated castor oil and essence, stir evenly, and the material liquid is light yellow transparent liquid.

Example 3

Embodiment 3 provides a kind of anti-dandruff control oil soothing essence, its specific implementation is the same as embodiment 1, the difference is that the Sophora flavescens extract, ginseng extract, burdock extract, orientalis leaf extract, ginger root The weight ratio of the extract, the red clover leaf extract and the mugwort leaf extract is 3:3:0.5:1:0.5:0.5:0.5.

Example 4

Embodiment 4 provides a kind of anti-dripping and oil-controlling soothing essence, its specific embodiment is the same as embodiment 1, the difference is that the moisturizer is 1,2-hexanediol and 1,3-propylene glycol; the 1,2 - The weight ratio of hexanediol and 1,3-propanediol is 1:3.

Example 5

Example 5 provides an anti-dandruff control oil soothing essence, the specific implementation of which is the same as that of Example 1, except that the weight percentage of the isododecane is 4%.

Example 6

Example 6 provides an anti-dripping and oil-controlling soothing essence, the specific implementation method of which is the same as that of Example 1, except that the filling volume ratio of the water phase and the oil phase in the step (4) is 1:2.

performance test method

1. Stability test: Set 2 parallel samples of the anti-shedding oil control soothing essence prepared in Examples 1-6, and place the parallel samples at 25°C and 40°C for 1 month respectively for stability measurement, the results See Table 1.

2. Water and oil layering situation: put the anti-shedding and oil-controlling soothing essence prepared in Example 1 and Example 3-6 into a 100mL stoppered measuring cylinder, shake it up and down 20 times at the same speed, stand for observation, and record After 5 minutes, the clarity of the interface and whether there are oil droplets hanging on the wall, the results are shown in Table 1.

Table 1:

25°C 40℃ interface clarity Hanging phenomenon Example 1 no change no change clear interface no wall Example 2 no change no change - - Example 3 no change water phase discoloration clear interface no wall Example 4 no change water phase discoloration clear interface no wall Example 5 no change Oil phase turbidity Oil phase turbidity Oil bead hanging on the wall Example 6 no change no change cloudy water Oil bead hanging on the wall

3. Efficacy test: 48 volunteers with scalp discomfort, not limited to men and women, were selected to try the anti-shedding and oil-controlling soothing essence described in Example 1. How to use: Take an appropriate amount of this product and apply it evenly on the scalp, massage gently with your hands or a scalp massager, use it once a day without rinsing; the single dosage is 6ml.

Test results: 37 volunteers felt that the hair was refreshing after use, 35 volunteers felt that there was almost no dandruff after use, 32 volunteers felt that there was almost no itching after use, 20 volunteers felt that the hair was soft and fluffy after use; 42 40 volunteers believed that the sample had the effect of improving scalp itching and small bumps.

4. The test steps for antibacterial effect are shown in Table 2, and the results are shown in Table 3 and Figure 1.

Table 2:

table 3:

Antibacterial zone diameter (mm) Example 1 <7 Example 2 7.4±0.2 Example 3 <7 Example 4 <7 Example 5 <7 Example 6 <7

5. Use experience test: Select 14 volunteers who have significant hair loss (refer to the average number of hair loss ≥ 30 hairs per day), not limited to men and women, and try the anti-hair loss control oil soothing essence 4 described in Examples 1-4 Day (every example), then repeat the above operation once (twice). The method of use is: in the semi-dry state of the hair, press 6ml/time and massage the whole head for 3-5 minutes, once a day. Efficacy evaluators fill in volunteers’ single and secondary use feelings (fragrance, color, thickness, refreshing feeling, etc.): 5 points-very satisfied, 4 points-satisfied, 3 points-average, 2 points-dissatisfied , 1 point-very dissatisfied, the following values are average values (rounded to one decimal place) and the test results are shown in Table 4.

Table 4:

Feedback from volunteers using Example 1: 1. 12 people feel that the scalp is cool and refreshing during use, and 2 people feel that the scalp is not cool and refreshing; The texture is moderate; 3 and 7 people think the dosage is too much, 2 people think the dosage is too little, and 5 people think the dosage is moderate.

Claims (10)

1. The anti-drop oil-control and soothing essence is characterized by comprising the following raw materials in percentage by weight: 1-10% of humectant, 0.9-8% of plant extract A, 0.05-5% of plant extract B, 0.2-3% of antibacterial agent, 0.005-3% of vitamin, 0.005-2% of skin conditioner, 0.1-1% of pH regulator, 0.001-5% of hydrolyzed yeast protein, 0.05-0.5% of thickener and the balance of deionized water;

preferably, the raw materials also comprise 5-30% ethanol, 0.5-10% isododecane or 0.5-5% PEG-40 hydrogenated castor oil, 0.1-1% preservative and 0.1-0.5% essence.

2. The anti-hair loss and oil control relief essence according to claim 1, wherein said humectant is selected from one or more of 1, 2-hexanediol, 1, 3-propanediol, glycerin, octanediol, sodium hyaluronate, trehalose.

3. The anti-drop oil-control relief essence according to claim 1, wherein the plant extract a is selected from one or more of a kuh-seng extract, a ginseng extract, a burdock extract, a biota orientalis extract, a ginger root extract, a red clover leaf extract, a mugwort leaf extract, a weeping forsythia extract, a peony root extract, and a polygonum multiflorum root extract.

4. The anti-drop oil-control relief essence according to claim 1, wherein said plant extract B is selected from one or more of olive oil, sea buckthorn seed oil, cherry oil, lavender oil, jasmine oil, rose oil, perilla leaf oil, menthol.

5. The anti-drop oil-control relief essence according to claim 1, wherein said antimicrobial agent is selected from one or more of dipotassium glycyrrhizinate, ethylhexyl glycerol, piroctone olamine salt, chlorhexidine, zinc pyrithione, ganbazole, ketoconazole.

6. The anti-hair loss and oil control relief essence according to claim 1, wherein said vitamins are selected from one or more of panthenol, biotin, vitamin E, vitamin a, vitamin D.

7. The anti-hair loss and oil control relief essence according to claim 1, wherein said skin conditioning agent is selected from one or more of arginine, zinc gluconate, niacinamide, bisabolol.

8. The anti-hair loss and oil control relief essence according to claim 1, wherein said pH adjuster is selected from one or more of sodium citrate, disodium hydrogen phosphate, and sodium dihydrogen phosphate.

9. The anti-drop oil-control relief essence according to claim 1, wherein said thickener is selected from any one of hydroxyethyl cellulose, hydroxypropyl methylcellulose, and carboxymethyl cellulose.

10. A preparation method of the anti-drop oil-control relief essence according to any one of claims 1-9, which is characterized in that the essence is prepared by uniformly mixing various raw materials in percentage by weight.

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