CN1162459A - High performance and quick effective skin penetrating and slow releasing Chinese medical paste and preparations - Google Patents
High performance and quick effective skin penetrating and slow releasing Chinese medical paste and preparations Download PDFInfo
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- CN1162459A CN1162459A CN 96104657 CN96104657A CN1162459A CN 1162459 A CN1162459 A CN 1162459A CN 96104657 CN96104657 CN 96104657 CN 96104657 A CN96104657 A CN 96104657A CN 1162459 A CN1162459 A CN 1162459A
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- borneolum syntheticum
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- pad pasting
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- 238000002360 preparation method Methods 0.000 title claims description 36
- 230000000149 penetrating effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 claims abstract description 52
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 32
- 229920002367 Polyisobutene Polymers 0.000 claims abstract description 19
- 235000000126 Styrax benzoin Nutrition 0.000 claims abstract description 18
- 206010002383 Angina Pectoris Diseases 0.000 claims abstract description 14
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 64
- 239000010410 layer Substances 0.000 claims description 40
- 238000000605 extraction Methods 0.000 claims description 34
- 235000010603 pastilles Nutrition 0.000 claims description 34
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims description 32
- 239000003208 petroleum Substances 0.000 claims description 32
- 239000000203 mixture Substances 0.000 claims description 21
- 229940079593 drug Drugs 0.000 claims description 19
- 239000000758 substrate Substances 0.000 claims description 19
- 235000015511 Liquidambar orientalis Nutrition 0.000 claims description 17
- 241000736148 Styrax Species 0.000 claims description 17
- 239000004870 Styrax Substances 0.000 claims description 17
- 229920000297 Rayon Polymers 0.000 claims description 16
- 239000011248 coating agent Substances 0.000 claims description 16
- 238000000576 coating method Methods 0.000 claims description 16
- 239000003921 oil Substances 0.000 claims description 16
- 239000000284 extract Substances 0.000 claims description 10
- 229940057995 liquid paraffin Drugs 0.000 claims description 10
- 239000011241 protective layer Substances 0.000 claims description 10
- 239000000341 volatile oil Substances 0.000 claims description 9
- 239000003973 paint Substances 0.000 claims description 8
- 239000002904 solvent Substances 0.000 claims description 8
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims description 6
- 239000002552 dosage form Substances 0.000 claims description 5
- 239000008194 pharmaceutical composition Substances 0.000 claims description 5
- 239000000853 adhesive Substances 0.000 claims description 4
- 239000004615 ingredient Substances 0.000 claims description 3
- 230000001070 adhesive effect Effects 0.000 claims description 2
- 239000000463 material Substances 0.000 claims description 2
- 238000000034 method Methods 0.000 claims description 2
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003292 glue Substances 0.000 claims 1
- 210000003097 mucus Anatomy 0.000 claims 1
- 208000029078 coronary artery disease Diseases 0.000 abstract description 5
- 239000011505 plaster Substances 0.000 abstract description 3
- ISAOCJYIOMOJEB-UHFFFAOYSA-N benzoin Chemical compound C=1C=CC=CC=1C(O)C(=O)C1=CC=CC=C1 ISAOCJYIOMOJEB-UHFFFAOYSA-N 0.000 abstract 2
- 235000019382 gum benzoic Nutrition 0.000 abstract 2
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 abstract 1
- 244000001632 Acorus gramineus Species 0.000 abstract 1
- 235000013073 Acorus gramineus Nutrition 0.000 abstract 1
- 241000758794 Asarum Species 0.000 abstract 1
- 240000000513 Santalum album Species 0.000 abstract 1
- 235000008632 Santalum album Nutrition 0.000 abstract 1
- 241001060310 Styracaceae Species 0.000 abstract 1
- 244000028419 Styrax benzoin Species 0.000 abstract 1
- 235000001361 Styrax officinalis Nutrition 0.000 abstract 1
- 235000008411 Sumatra benzointree Nutrition 0.000 abstract 1
- 229960002130 benzoin Drugs 0.000 abstract 1
- 229940116229 borneol Drugs 0.000 abstract 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 1
- SQDFHQJTAWCFIB-UHFFFAOYSA-N n-methylidenehydroxylamine Chemical compound ON=C SQDFHQJTAWCFIB-UHFFFAOYSA-N 0.000 abstract 1
- SNIOPGDIGTZGOP-UHFFFAOYSA-N Nitroglycerin Chemical compound [O-][N+](=O)OCC(O[N+]([O-])=O)CO[N+]([O-])=O SNIOPGDIGTZGOP-UHFFFAOYSA-N 0.000 description 7
- 239000000006 Nitroglycerin Substances 0.000 description 7
- 229960003711 glyceryl trinitrate Drugs 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 4
- 230000009471 action Effects 0.000 description 3
- 239000004480 active ingredient Substances 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 238000013270 controlled release Methods 0.000 description 2
- IZEKFCXSFNUWAM-UHFFFAOYSA-N dipyridamole Chemical compound C=12N=C(N(CCO)CCO)N=C(N3CCCCC3)C2=NC(N(CCO)CCO)=NC=1N1CCCCC1 IZEKFCXSFNUWAM-UHFFFAOYSA-N 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 230000005923 long-lasting effect Effects 0.000 description 2
- 230000002107 myocardial effect Effects 0.000 description 2
- 208000031225 myocardial ischemia Diseases 0.000 description 2
- 238000005457 optimization Methods 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000003860 topical agent Substances 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- KKJUPNGICOCCDW-UHFFFAOYSA-N 7-N,N-Dimethylamino-1,2,3,4,5-pentathiocyclooctane Chemical compound CN(C)C1CSSSSSC1 KKJUPNGICOCCDW-UHFFFAOYSA-N 0.000 description 1
- 206010003225 Arteriospasm coronary Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000003890 Coronary Vasospasm Diseases 0.000 description 1
- 206010019233 Headaches Diseases 0.000 description 1
- 206010020751 Hypersensitivity Diseases 0.000 description 1
- 206010031127 Orthostatic hypotension Diseases 0.000 description 1
- 206010047700 Vomiting Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000443 aerosol Substances 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- 230000007815 allergy Effects 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000003257 anti-anginal effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 230000003130 cardiopathic effect Effects 0.000 description 1
- 208000015606 cardiovascular system disease Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 201000011634 coronary artery vasospasm Diseases 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 231100000869 headache Toxicity 0.000 description 1
- 230000000004 hemodynamic effect Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- 230000004410 intraocular pressure Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000004165 myocardium Anatomy 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000036284 oxygen consumption Effects 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000010349 pulsation Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- GOLXNESZZPUPJE-UHFFFAOYSA-N spiromesifen Chemical compound CC1=CC(C)=CC(C)=C1C(C(O1)=O)=C(OC(=O)CC(C)(C)C)C11CCCC1 GOLXNESZZPUPJE-UHFFFAOYSA-N 0.000 description 1
- -1 stable Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000008673 vomiting Effects 0.000 description 1
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- Medicinal Preparation (AREA)
Abstract
A skin-penetrating slow-releasing plaster as an exterior-used medicine for curing coronary heart-disease and angina pectoris is prepared from borneol, the active components extracted from benzoin, sandal wood, asarum herb, grass-leaved sweetflag rhizome and storax, polyisobutene, nitrone and atoleine.
Description
The present invention is a kind of cardiopathic topical agent that is used for the treatment of, be specifically a kind of be the transdermal slow-release skin pad pasting that effective ingredient is prepared from Chinese medicine, have treatment coronary heart disease, anginal medical function.The present invention also comprises can be prepared into any forms of pharmaceutical compositions, belongs to field of pharmaceutical preparations.
Angina pectoris is a kind of common old cardiovascular system diseases, has characteristics such as morbidity is hurried, patient's condition danger.Therefore prevention that should disease is the problem of research with treatment always.At present preparations such as oral, the buccal of treatment angina pectoris disease, injection and aerosol have been widely used in clinically, have obtained certain therapeutic effect.But these preparations are all very short action time, keep certain drug effect for a long time as need, must successive administration.This has all brought inconvenience for doctor and patient.Effective western medicine medicine nitroglycerin, though many toxic and side effects are arranged, consequently many patients can not use, but still are present common drug clinically.For the treatment of angina pectoris, still lack the advanced dosage form of efficient, long lasting Chinese medicine.Although the present domestic relevant herbal penetration therapy Study on Coronary Heart Disease of a small amount of bibliographical information that has, for example, " technology of Rhizoma Chuanxiong plaster and quality standard ", imperial ambition, " Chinese patent medicine ", 1994,16 (12), 3-4; Chinese patent CN1089833 " treatment coronary heart disease, anginal Chinese medicine external use plaster " etc.These preparations still have following deficiency: 1, dosage form is the extractum of unguentum or extraction, and its degree of absorption is lower, does not see the report of relevant treatment angina pectoris membrane agent; 2, form the Chinese medicine shortage permeability of medicament itself, directly have influence on therapeutic effect; But 3, there is not to add the pharmaceutics composition of controlled release; 4, some only limits to clinical observation, still is not prepared into medicament.Therefore, preparing a kind of easy to use and good external used medicine of curative effect has been angina pectoris patient serious hope for a long time.The topical agent that particularly needs a kind of instant effect, effective and longer duration.
The object of the invention provides a kind of externally applied transdermal slow release skin pad pasting that is used for the treatment of angina pectoris.
The object of the invention also is to provide a kind of externally applied transdermal slow release skin pad pasting preparation method for the treatment of angina pectoris.
The middle pharmaceutically active ingredient of preparation pad pasting of the present invention is that Chinese medicine component with following weight proportion is that raw material is produced:
Benzoinum 500-1000 gram
Borneolum Syntheticum 10-1000 gram
Lignum Santali Albi 200-1000 gram
Herba Asari 0.1-200 gram
Rhizoma Acori Graminei 0.1-700 gram
Styrax 50-2000 gram.
Above-mentioned Chinese medicine proportion optimization consumption is:
Benzoinum 700-800 gram
Borneolum Syntheticum 500-800 gram
Lignum Santali Albi 300-700 gram
Herba Asari 1-100 gram
Rhizoma Acori Graminei 1-500 gram
Styrax 600-800 gram.
Above-mentioned Chinese medicine proportioning consumption is more preferably:
Benzoinum 700-800 gram
Borneolum Syntheticum 500-800 gram
Lignum Santali Albi 300-700 gram
Herba Asari 50-80 gram
Rhizoma Acori Graminei 50-400 gram
Styrax 500-600 gram.
The middle pharmaceutically active ingredient of preparation pad pasting of the present invention also can be that raw material is produced with the Chinese medicine component of following weight proportion:
Borneolum Syntheticum 10-1000 gram
Herba Asari 0.1-200 gram
Rhizoma Acori Graminei 0.1-700 gram
Styrax 50-2000 gram.
Above-mentioned Chinese medicine proportion optimization consumption is:
Borneolum Syntheticum 500-800 gram
Herba Asari 1-100 gram
Rhizoma Acori Graminei 1-500 gram
Styrax 600-800 gram.
Above-mentioned Chinese medicine proportioning consumption is more preferably:
Borneolum Syntheticum 500-800 gram
Herba Asari 50-80 gram
Rhizoma Acori Graminei 50-400 gram
Styrax 500-600 gram.
Transdermal slow-release skin pad pasting of the present invention except containing above-mentioned middle pharmaceutically active ingredient, also contains polyisobutylene 300-2000 gram, azone 10-500 milliliter, liquid paraffin 10-500 milliliter.Certainly, can be prepared into any known drug dosage form with above-mentioned pharmaceutical composition, as, peroral dosage form, spray-type etc.
The step of preparation process of transdermal slow-release skin pad pasting of the present invention is:
1, extracts effective ingredient
The medicine of above-mentioned weight proportion, except that Borneolum Syntheticum, all the other all extract volatile oil according to the extracting method of routine, and are with the Borneolum Syntheticum mixing, standby then;
2, the pastille storage storehouse of preparation pad pasting
Get polyisobutylene 300-2000 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in petroleum ether and the cyclohexane extraction mixed liquor 50-1000 milliliter, add above-mentioned drug volatilization oil and Borneolum Syntheticum mixture again, and azone 10-500 milliliter, mix homogeneously is prepared into the pastille substrate of three kinds of different gradient concentrations; It is respectively 40-50%, 30-40% and 20-30% that these three kinds of substrate respectively contain medicine weight percent concentration scope; During preparation these three kinds of pastille substrate are coated and mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes pastille storage storehouse.Volatilize solvent then.
3, preparation viscose
Get polyisobutylene 300-1000 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in petroleum ether and the cyclohexane extraction 50-1000 milliliter, add liquid paraffin 10-500 milliliter and 60-5000 gram above-mentioned drug volatilization oil and Borneolum Syntheticum mixture, mix homogeneously.
4, the preparation of adhesive shell system preparation capable of permeating skin
Coating one layer thickness is the viscose of the step 3 of 0.05-0.3 millimeter on the pastille storage storehouse of step 2 preparation, and covers upward protective layer.
The mounting of transdermal slow-release skin pad pasting of the present invention is equipped with layer and can uses the material fully of mounting that is suitable on any pharmaceutics.Said protective layer can be plastic sheeting or the self-adhesive paper that is suitable on any pharmaceutics.
The Chinese medicine of above-mentioned formula ratio generally can be prepared into 1000-5000 sheet pad pasting.
The general every subsides content of dispersion of transdermal slow-release skin pad pasting of the present invention is the 0.4-8 gram.
Transdermal slow-release skin pad pasting of the present invention is compared with the other treatment treating coronary heart disease and angina pectoris, has following characteristics:
1, transdermal slow-release skin pad pasting of the present invention is a pure Chinese medicinal preparation, and therapeutical effect is not less than nitroglycerin;
2, compare with nitroglycerin.Its advantage is: (1) does not have the common toxic and side effects of nitroglycerin, as, feel sick, postural hypotension, vomiting, vascular pulsation headache etc.; (2) there is not the use contraindication of nitroglycerin, as, forbid, intracranial pressure low or increased intraocular pressure disease patient in nitroglycerin allergy, serious anemia, blood pressure; (3) patient does not produce toleration after using; (4) therapeutical effect is more lasting, patient 1/3-1/4 is arranged approximately after treatment about a course of treatment, can keep quite a while angina pectoris degree and obviously alleviate or do not show effect; (5) patient who fails to respond to any medical treatment for nitroglycerin, still effective with said preparation, for angina pectoris after the myocardial infarction, the angina pectoris of PTCA postoperative excellent curative is arranged all also;
3, transdermal slow-release skin pad pasting of the present invention can play slow release, controlled-release function owing to be to adopt advanced technology to make, and makes lasting medicine, stable, pastes with once, can keep pharmacological action 24-48 hour, and easy to use, has efficient, long lasting characteristics;
4, to the research of the hematoblastic function of angina pectoris patient; and myocardial ultrastructure and different Chinese and western drugs show the result of study of the different protective effects of cardiac muscle when the animal coronary vasospasm caused myocardial ischemia; transdermal slow-release skin pad pasting of the present invention has good protective action to myocardial ischemia, and good actions such as the cardiac hemodynamic of improvement, reduction myocardial oxygen consumption are arranged.
Embodiment 1
Get Benzoinum 600 grams, Lignum Santali Albi 500 grams, Herba Asari 100 grams, Rhizoma Acori Graminei 100 grams, Styrax 800 grams add in the multi-function extractor, extract respectively and collect volatile oil, and are standby;
Get polyisobutylene 800 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 150 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 500 grams again, and azone 50-500 milliliter, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 800 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 150 milliliters of petroleum ether and the cyclohexane extraction, add 100 milliliters of liquid paraffin and above-mentioned drug volatilization oil and the Borneolum Syntheticum of 200 grams, mix homogeneously is made viscose, and is standby;
Coating one layer thickness is the viscose of 0.2 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 2000 pad pastings.
Embodiment 2
Get Benzoinum 800 grams, Lignum Santali Albi 300 grams, Herba Asari 150 grams, Rhizoma Acori Graminei 500 grams, Styrax 600 grams add in the multi-function extractor, extract respectively and collect volatile oil, and are standby;
Get polyisobutylene 700 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 200 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 800 grams again, and 100 milliliters of azones, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 700 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 200 milliliters of petroleum ether and the cyclohexane extraction, add 200 milliliters of liquid paraffin and above-mentioned drug volatilization oil and the Borneolum Syntheticum of 400 grams, mix homogeneously is made viscose, and is standby;
Coating one layer thickness is the viscose of 0.1 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 2000 pad pastings.
Embodiment 3
Get Benzoinum 900 grams, Lignum Santali Albi 200 grams, Herba Asari 50 grams, Rhizoma Acori Graminei 400 grams, Styrax 500 grams add in the multi-function extractor, extract and collect volatile oil, and are standby;
Get polyisobutylene 600 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 250 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 800 grams again, and 50 milliliters of azones, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 600 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1), add 50 milliliters of liquid paraffin and 400 and restrain above-mentioned drug volatilization oil and Borneolum Syntheticum, mix homogeneously is made viscose, and is standby in 250 milliliters of petroleum ether and the cyclohexane extraction;
Coating one layer thickness is the viscose of 0.1 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 2000 pad pastings.
Embodiment 4
Get Herba Asari 100 grams, Rhizoma Acori Graminei 100 grams, Styrax 800 grams add in the multi-function extractor, extract respectively and collect volatile oil, and are standby;
Get polyisobutylene 800 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 150 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 500 grams again, and azone 50-500 milliliter, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 800 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 150 milliliters of petroleum ether and the cyclohexane extraction, add 100 milliliters of liquid paraffin and above-mentioned drug volatilization oil and the Borneolum Syntheticum of 200 grams, mix homogeneously is made viscose, and is standby;
Coating one layer thickness is the viscose of 0.2 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 2000 pad pastings.
Embodiment 5
Get Herba Asari 150 grams, Rhizoma Acori Graminei 500 grams, Styrax 600 grams add in the multi-function extractor, extract respectively and collect volatile oil, and are standby;
Get polyisobutylene 700 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 200 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 800 grams again, and 100 milliliters of azones, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 700 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 200 milliliters of petroleum ether and the cyclohexane extraction, add 200 milliliters of liquid paraffin and above-mentioned drug volatilization oil and the Borneolum Syntheticum of 400 grams, mix homogeneously is made viscose, and is standby;
Coating one layer thickness is the viscose of 0.1 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 2000 pad pastings.
Embodiment 6
Get Herba Asari 50 grams, Rhizoma Acori Graminei 400 grams, Styrax 500 grams add in the multi-function extractor, extract and collect volatile oil, and are standby;
Get polyisobutylene 600 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1) in 250 milliliters of petroleum ether and the cyclohexane extraction, add above-mentioned drug volatilization oil and Borneolum Syntheticum 400 grams again, and 50 milliliters of azones, mix homogeneously is prepared into and contains the pastille substrate that medicine weight percent concentration scope is respectively three kinds of different gradient concentrations of 40-50%, 30-40% and 20-30%; These three kinds of pastille substrate are coated mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes nine layers of pastille and stores storehouses.Volatilize solvent then;
Get polyisobutylene 600 gram and be dissolved in that (wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1), add 50 milliliters of liquid paraffin and 100 and restrain above-mentioned drug volatilization oil and Borneolum Syntheticum, mix homogeneously is made viscose, and is standby in 250 milliliters of petroleum ether and the cyclohexane extraction;
Coating one layer thickness is the viscose of 0.1 millimeter above-mentioned preparation on the pastille storage storehouse of above-mentioned preparation, and covers upward protective layer, makes 1500 pad pastings.
Claims (10)
1, a kind of transdermal slow-release skin pad pasting that is used for the treatment of angina pectoris is characterized in that the volatile oil that it contains Borneolum Syntheticum and extracts from Benzoinum, Lignum Santali Albi, Herba Asari, Rhizoma Acori Graminei, Styrax, and the weight proportion of said Chinese medicine is
Benzoinum 500-1000 gram
Borneolum Syntheticum 10-1000 gram
Lignum Santali Albi 200-1000 gram
Herba Asari 0.1-200 gram
Rhizoma Acori Graminei 0.1-700 gram
Styrax 50-2000 gram.
2, according to the pad pasting of claim 1, the weight proportion of said Chinese medicine is
Benzoinum 700-800 gram
Borneolum Syntheticum 500-800 gram
Lignum Santali Albi 300-700 gram
Herba Asari 1-100 gram
Rhizoma Acori Graminei 1-500 gram
Styrax 600-800 gram.
3, according to the pad pasting of claim 1, the weight proportion of said Chinese medicine is
Benzoinum 800 grams
Borneolum Syntheticum 800 grams
Lignum Santali Albi 300 grams
Herba Asari 150 grams
Rhizoma Acori Graminei 500 grams
Styrax 600 grams
4,, it is characterized in that it also contains following substrate according to the pad pasting of claim 1:
Polyisobutylene 300-2000 gram
Azone 10-500 milliliter
Liquid paraffin 10-500 milliliter.
5, the preparation technology of the said pad pasting of claim 1 comprises the steps:
A, extraction effective ingredient
By the medicine of described weight proportion, except that Borneolum Syntheticum, all the other all extract volatile oil according to the extracting method of routine, and are with the Borneolum Syntheticum mixing, standby then;
The pastille storage storehouse of b, preparation pad pasting
Getting polyisobutylene 300-2000 gram is dissolved in petroleum ether and the cyclohexane extraction mixed liquor 50-1000 milliliter, wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1, add above-mentioned drug volatilization oil and Borneolum Syntheticum mixture again, and azone 10-500 milliliter, mix homogeneously is prepared into the pastille substrate of three kinds of different gradient concentrations; It is respectively 40-50%, 30-40% and 20-30% that these three kinds of substrate respectively contain medicine weight percent concentration scope; During preparation these three kinds of pastille substrate are coated and mount on the backing layer, paint three layers by the order of high, medium and low concentration, every layer of coating three times constitutes pastille storage storehouse.Volatilize solvent then;
C, preparation viscose
Getting polyisobutylene 300-1000 gram is dissolved in petroleum ether and the cyclohexane extraction 50-1000 milliliter, wherein the ratio of petroleum ether and cyclohexane extraction is 1: 100-100: 1, add liquid paraffin 10-500 milliliter and 60-5000 gram above-mentioned drug volatilization oil and Borneolum Syntheticum mixture again, mix homogeneously, glue mucus;
The preparation of d, adhesive shell system preparation capable of permeating skin
Coating one layer thickness is the viscose of the step c of 0.05-0.3 millimeter on the pastille storage storehouse of step b preparation, and covers upward protective layer, promptly.
6, according to the technology of claim 5, wherein said pad pasting is mounted and is equipped with layer and can uses the material fully of mounting that is suitable on any pharmaceutics.
7, according to the technology of claim 5, wherein said protective layer can be plastic sheeting or the self-adhesive paper that is suitable on any pharmaceutics.
8, a kind of pharmaceutical composition is characterized in that it comprises
Borneolum Syntheticum 10-1000 gram
Herba Asari 0.1-200 gram
Rhizoma Acori Graminei 0.1-700 gram
Styrax 50-2000 gram.
9, the pharmaceutical composition of claim 8 is characterized in that it also contains
Benzoinum 500-1000 gram
Lignum Santali Albi 200-1000 gram
10, claim 8 or 9 pharmaceutical composition is characterized in that it can be prepared into any pharmaceutical dosage form.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96104657A CN1054529C (en) | 1996-04-16 | 1996-04-16 | High performance and quick effective skin penetrating and slow releasing Chinese medical paste and preparations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN96104657A CN1054529C (en) | 1996-04-16 | 1996-04-16 | High performance and quick effective skin penetrating and slow releasing Chinese medical paste and preparations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1162459A true CN1162459A (en) | 1997-10-22 |
| CN1054529C CN1054529C (en) | 2000-07-19 |
Family
ID=5118424
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96104657A Expired - Fee Related CN1054529C (en) | 1996-04-16 | 1996-04-16 | High performance and quick effective skin penetrating and slow releasing Chinese medical paste and preparations |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1054529C (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061252C (en) * | 1997-12-02 | 2001-01-31 | 牛永杰 | Preparation of Chinese medicine for curing cardiac and cerebral diseases atomized by oxygen and its preparation process |
| CN102397311A (en) * | 2011-11-28 | 2012-04-04 | 成都盛尔嘉科技有限公司 | Coronary heart disease preparation and preparation method thereof |
| CN104547287A (en) * | 2014-12-30 | 2015-04-29 | 范靖 | Slow-release medicine patch for stenocardia |
| CN104840449A (en) * | 2015-04-22 | 2015-08-19 | 崔建平 | Medical patch and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1089833A (en) * | 1993-01-18 | 1994-07-27 | 贵州三力技术发展有限公司 | Treatment coronary heart disease, anginal Chinese medicine external use plaster |
-
1996
- 1996-04-16 CN CN96104657A patent/CN1054529C/en not_active Expired - Fee Related
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061252C (en) * | 1997-12-02 | 2001-01-31 | 牛永杰 | Preparation of Chinese medicine for curing cardiac and cerebral diseases atomized by oxygen and its preparation process |
| CN102397311A (en) * | 2011-11-28 | 2012-04-04 | 成都盛尔嘉科技有限公司 | Coronary heart disease preparation and preparation method thereof |
| CN104547287A (en) * | 2014-12-30 | 2015-04-29 | 范靖 | Slow-release medicine patch for stenocardia |
| CN104840449A (en) * | 2015-04-22 | 2015-08-19 | 崔建平 | Medical patch and preparation method thereof |
| CN104840449B (en) * | 2015-04-22 | 2018-05-18 | 崔建平 | A kind of medicine patch and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1054529C (en) | 2000-07-19 |
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