CN116098816A - A kind of preparation method of fluoride anti-caries foam - Google Patents

Abstract

The invention discloses a preparation method of fluorinated caries-preventing foam, belonging to the technical field of dental treatment; the method specifically comprises the following steps: step 1, adding 77.5% -87.5% of solvent and 5% -8% of humectant into a stirrer, starting the stirrer to adjust the rotating speed to 700-1300r/min, and heating to 90 ℃; step 2, after the temperature is stable, adding 0.2% -0.5% of emulsifying agent, and continuously stirring until the emulsifying agent is dissolved; step 3, after the emulsifier is dissolved, adding condensed water into the stirrer for cooling, and cooling to 60 ℃; step 4, after the temperature is stable, adding 10% -12% of foaming agent, 0.5% -1% of anti-adhesive agent, 1.0% -1.5% of fluoride ion regulator, sweetener and essence, and stirring until all the components are dissolved; step 5, adding 0.1% -0.5% of acidulant to adjust the PH to 3.5-8.5 after dissolution, and adding condensed water again to reduce the temperature to 25 ℃; and 6, filling and aerating. The invention has simple production process and low cost, and has a production mode which can be realized and can be practically applied.

Description

A kind of preparation method of fluoride anti-caries foam

technical field

The invention relates to the technical field of dental treatment, in particular to a method for making fluoride anti-caries foam.

Background technique

Fluoride foam anti-caries needs to be carried out under the operation of a professional dentist. The main purpose is to form fluoride minerals on the surface of the teeth. The mineral layer is relatively acidic and has a certain resistance. At the same time, fluoride can slowly release fluoride on the surface of the teeth. , will have certain benefits in the prevention of dental caries.

In the prior art, the patent application number 200510090736.3 discloses a water-soluble fluorinated anti-caries foam. Its formula is too complicated and difficult to manufacture. It is very difficult to realize in practice, and the manufacturing process is extremely cumbersome, resulting in increased production costs. The propellant used is a mixture of propane and isopropane. Propane and isopropane have an anesthetic effect on the human body; and propane and isopropane are soluble in water, which affects the shelf life of the product; because of the gas production process, isopropane gas has a peculiar smell, causing Patients feel poor in use.

Contents of the invention

Aiming at the problems existing in the above-mentioned background technology, the present invention proposes a manufacturing method of fluorinated anti-caries foam; the method should have a simple production process, low cost, and a practically applicable production method.

In order to achieve the above object, the technical scheme adopted in the present invention is:

A preparation method of fluoride anti-caries foam, comprising the following steps:

Step 1, add 77.5%-87.5% solvent and 5%-8% humectant to the mixer, turn on the mixer and adjust the speed to 700-1300r/min, and raise the temperature to 90°C;

Step 2, after the temperature stabilizes, add 0.2%-0.5% emulsifier, and continue stirring until the emulsifier is dissolved;

Step 3, after the emulsifier is dissolved, add condensed water to the mixer to cool down, and cool down to 60°C;

Step 4, after the temperature stabilizes, add 10%-12% of foaming agent, 0.5%-1% of anti-caking agent, 1.0%-1.5% of fluoride ion regulator, sweetener and essence, and stir until all dissolve;

Step 5, after dissolving, add 0.1%-0.5% acidulant to adjust the pH to 3.5-8.5, add condensed water again to lower the temperature to 25°C;

Step 6, filling and refilling.

Further, in step 6, during filling and gas filling, the propellant used is tetrafluoroethylene gas.

Further, the solvent in step 1 is purified water.

Further, the humectant in step 1 is glycerol.

Further, the emulsifier in the step 2 is stearic acid.

Further, the foaming agent in step 4 is lauryl alcohol, the anti-caking agent is oleic acid amide, and the fluoride ion regulator is sodium fluoride.

Further, the acidulant in step 5 is phosphoric acid.

The beneficial effect that the present invention produces by adopting above-mentioned technical scheme is:

1. The production process of the present invention should be simple, the cost should be low, and there should be a production mode that can be realized and practically applied.

2. The fluoride anti-caries foam produced by the present invention uses a propellant that is stable in foaming, has no peculiar smell, and has no anesthetic effect on the human body.

3. The product of the present invention has simple formula, easy proportioning, and is not easy to make mistakes.

Detailed ways

Below, the present invention will be further described in conjunction with specific embodiments.

In order to illustrate the technical solutions of the embodiments of the present invention more clearly, the following will briefly introduce the embodiments. Obviously, the following descriptions are only some embodiments of the present invention.

A preparation method of fluoride anti-caries foam, comprising the following steps:

Step 1, add 77.5%-87.5% solvent and 5%-8% humectant to the mixer, turn on the mixer and adjust the speed to 700-1300r/min, and raise the temperature to 90°C;

Step 2, after the temperature stabilizes, add 0.2%-0.5% emulsifier, and continue stirring until the emulsifier is dissolved;

Step 3, after the emulsifier is dissolved, add condensed water to the mixer to cool down, and cool down to 60°C;

Step 4, after the temperature stabilizes, add 10%-12% of foaming agent, 0.5%-1% of anti-caking agent, 1.0%-1.5% of fluoride ion regulator, sweetener and essence, and stir until all dissolve;

Step 5, after dissolving, add 0.1%-0.5% acidulant to adjust the pH to 3.5-8.5, add condensed water again to lower the temperature to 25°C;

Step 6, filling and refilling.

Further, in step 6, during the filling process, the propellant used is 0.4-0.5mpa tetrafluoroethylene gas.

Further, the solvent in step 1 is purified water.

Further, the humectant in step 1 is glycerol.

Further, the emulsifier in the step 2 is stearic acid.

Further, the foaming agent in step 4 is lauryl alcohol, the anti-caking agent is oleic acid amide, and the fluoride ion regulator is sodium fluoride.

Further, the acidulant in step 5 is phosphoric acid.

Below is a more specific embodiment:

First add 77.5%-87.5% solvent and 5%-8% humectant to the mixer, turn on the mixer and adjust the speed to 700-1300r/min, and raise the temperature to 90°C, add 0.2%-0.5% after the temperature stabilizes Emulsifier, stir until dissolved; stir until dissolved, turn on the condensate and cool down to 60°C, add 10%-12% foaming agent, 0.5%-1% anti-adhesive agent and 1.0%-1.5% after the temperature is stable The fluoride ion regulator, the right amount of sweetener and the right amount of essence, stir until dissolved; after dissolving, add 0.1%-0.5% acidulant to adjust the pH to 3.5-8.5, and then turn on the condensed water to lower the temperature to room temperature. Then fill and refill.

The propellant used is tetrafluoroethylene (perfluoroethylene) gas, which is filled with 0.4-0.5mpa tetrafluoroethylene gas when filling and inflating.

The humectant used is glycerol (glycerin), the emulsifier is stearic acid, the foaming agent is lauryl alcohol, the anti-adhesive agent is oleic acid amide, the fluoride ion regulator is sodium fluoride, the acidulant is phosphoric acid, and the solvent for purified water.

Rationale for using the above materials:

In the process of product manufacturing, feeding is carried out according to the physical and chemical properties of raw materials. Stearic acid is slightly soluble in cold water, and the solubility increases with the increase of water temperature. Therefore, in the first step of feeding, first add purified water and glycerin and raise the water temperature. Adding water temperature and glycerin will increase the solubility of stearic acid and shorten the stirring time; in the second part of feeding, there is no chemical reaction between the foaming agent and anti-adhesive agent, fluoride ion regulator, essence and sweetener, so it can be Feed together to reduce the number of feeds, and finally use an acidifier to adjust the pH value. This production method has fewer production steps and short production time, which can save production costs.

The propellant of fluorinated foam is traditionally used as a mixed gas of propane and isobutane. It needs to be inflated twice during the filling process in production. The production efficiency is low, and propane and isobutane have a certain concentration in water. Solubility, it may be that the air pressure of the product is insufficient during the shelf life, and the fluidity of the sprayed foam is good, which leads to an increase in the absorption of fluoride ions by the patient; moreover, propane and isobutane gas have a certain anesthetic effect on the human body and can cause dizziness and nausea; The reason for the gas process is that there will be impurities in the isopropane gas, which will cause the peculiar smell of the isopropane gas. It is the peculiar smell of the fluorinated foam product, which will reduce the patient's experience.

Tetrafluoroethylene gas has no peculiar smell, it is non-natural gas for secondary preparation, and has less impurity content, which makes patients feel better during use; tetrafluoroethylene is insoluble in water, and will not reduce the foaming performance of the product over time ; Tetrafluoroethylene gas has no anesthesia to the human body, and will not cause dizziness, nausea and other symptoms in patients after use; the combination of tetrafluoroethylene gas and foaming agent lauryl alcohol produces dense foam with poor fluidity, and this performance can It is maintained for 20 minutes, which is completely longer than the caries prevention treatment time of the patient (the caries prevention treatment time is 2-3 minutes). Using tetrafluoroethylene gas as a propellant, the foaming is stable, no peculiar smell, no anesthetic effect on the human body, and will not cause dizziness, nausea and other symptoms after use, and the patient feels good when using it.

The humectant used in the product is glycerol, which has both hydrophilic and lipophilic properties. This characteristic endows glycerol with the function of locking water and meets the requirements of the product humectant; the acidifier is phosphoric acid, which can Reacting with hydroxyapatite on the tooth surface can react impurities and initial caries on the tooth surface and demineralize the tooth surface. Only one raw material of phosphoric acid can meet the requirements of the acidifying agent of the product; the fluoride ion regulator is sodium fluoride , the fluoride ions released by sodium fluoride can meet the fluoride ions required for the remineralization of the tooth surface and thicken the enamel, and meet the requirements of the fluoride ion regulator; oleic acid amide can prevent the materials in the product from coagulating and appear Precipitation to meet the requirements of anti-adhesives; stearic acid can make the solute dispersed more uniformly, and can also emulsify the solution to increase the viscosity, which can meet the requirements of emulsifiers; lauryl alcohol is a surfactant and also has emulsifying effect , can cooperate with stearic acid to emulsify, and combine with propellant tetrafluoroethylene gas to form dense and non-flowing foam, which meets the requirements of blowing agent. The formula of this product is simple, and the material of each component is single, so it is not easy to make mistakes in the proportioning.

Claims (7)

1. a preparation method of fluoride anti-caries foam, is characterized in that, comprises the following steps: Step 1, add 77.5%-87.5% solvent and 5%-8% humectant to the mixer, turn on the mixer and adjust the speed to 700-1300r/min, and raise the temperature to 90°C; Step 2, after the temperature stabilizes, add 0.2%-0.5% emulsifier, and continue stirring until the emulsifier is dissolved; Step 3, after the emulsifier is dissolved, add condensed water to the mixer to cool down, and cool down to 60°C; Step 4, after the temperature stabilizes, add 10%-12% of foaming agent, 0.5%-1% of anti-caking agent, 1.0%-1.5% of fluoride ion regulator, sweetener and essence, and stir until all dissolve; Step 5, after dissolving, add 0.1%-0.5% acidulant to adjust the pH to 3.5-8.5, add condensed water again to lower the temperature to 25°C; Step 6, filling and refilling. 2. The method for making a fluorinated anti-caries foam according to claim 1, characterized in that, in step 6, during the filling process, the propellant used is tetrafluoroethylene gas. 3. The preparation method of a kind of fluoride anti-caries foam according to claim 1, characterized in that, the solvent in step 1 is purified water. 4. The preparation method of a kind of fluoride anti-caries foam according to claim 1, characterized in that the humectant in step 1 is glycerol. 5. The preparation method of a kind of fluoride anti-caries foam according to claim 1, characterized in that, the emulsifier in the step 2 is stearic acid. 6. the manufacture method of a kind of fluoride anti-caries foam according to claim 1, is characterized in that, the whipping agent in the described step 4 is lauryl alcohol, and anti-adhesive agent is oleic acid amide, and fluoride ion regulator to sodium fluoride. 7. The preparation method of a kind of fluoride anti-caries foam according to claim 1, characterized in that the acidifying agent in step 5 is phosphoric acid.