CN115903054A - Reagent strip reagent leakage detection device - Google Patents

Abstract

The invention provides a reagent strip reagent leakage irrigation detection device, which comprises a detection assembly, wherein the detection assembly is provided with a loading box body and a non-contact liquid flow induction assembly, a first through hole which can correspond to a reagent hole of a reagent strip is formed in the loading box body, the non-contact liquid flow induction assembly comprises a liquid flow induction sheet and a control panel, a frequency synthesizer is arranged on the control panel, the frequency synthesizer is provided with an extension line, the extension line is electrically connected with the liquid flow induction sheet, a second through hole is formed in the liquid flow induction sheet, a liquid injection pipe is suspended at an orifice of one side, away from the first through hole, of the second through hole, a liquid outlet of the liquid injection pipe, the first through hole and the second through hole are coaxially arranged, a detection circuit is arranged in the control panel, and the detection circuit can judge whether reagent liquid flows through the second through hole according to an output signal of the frequency synthesizer. The method realizes the judgment of the reagent liquid leakage filling of the reagent hole by utilizing the sensed capacitance change condition without manual judgment, and has higher detection sensitivity and more reliable detection result.

Description

Reagent strip reagent leakage detection device

technical field

The invention belongs to the field of reagent filling device design, in particular to a reagent strip reagent leakage detection device.

Background technique

In the liquid detection devices commonly used in the prior art, optical detection or weight detection is generally used to identify whether the reagent is leaked or not. However, due to the extremely low amount of reagents filled in the reagent strips, most of which are concentrated below 100 microliters and the reagent strips are moving rapidly on the production line, the commonly used weight detection methods on the market can no longer meet the required accuracy and efficiency requirements; And because most of the filling reagents are sensitive to light, the optical detection method is also not applicable. Based on this, at present, for the reagent strip reagent filling system, whether the reagent strip is leaked or not is mostly used to observe whether the droplet falls (flow down filling) with the naked eye, which is very labor-intensive and has poor reliability. Based on this, the present invention is proposed.

Contents of the invention

Therefore, the technical problem to be solved in the present invention is to provide a reagent strip reagent leakage detection device, to overcome the reagent strip leakage filling in the reagent strip reagent filling system in the prior art and need to use artificial naked eyes to observe whether the droplet falls, Deficiencies that are labor-intensive and less reliable.

In order to solve the above problems, the present invention provides a reagent leakage detection device for reagent strips. The reagent hole corresponds to the first through hole, the non-contact liquid flow sensing component includes a liquid flow sensing sheet and a control board, wherein the control board has a frequency synthesizer, and the frequency synthesizer has an extension line, The extension line is electrically connected to the liquid flow sensing sheet, and the liquid flow sensing sheet is configured with a second through hole, and a injection hole is suspended at the opening of the second through hole on the side away from the first through hole. liquid pipe, and the outlet of the liquid injection pipe, the first through hole and the second through hole are coaxially arranged, and a detection circuit is arranged in the control board, and the detection circuit can be based on the frequency The output signal of the combiner judges whether there is reagent liquid flowing through the second through hole.

In some embodiments, the material of the loading box is electromagnetic shielding material or the loading box has an electromagnetic shielding layer.

In some embodiments, there are multiple first through holes on the loading box, and the multiple first through holes are arranged at intervals along the first direction, and each of the first through holes is respectively provided with The non-contact liquid flow sensing sheet and the liquid injection tube.

In some embodiments, the loading box has an electromagnetic shielding portion, and the electromagnetic shielding portion is located between two adjacent liquid flow sensing sheets.

In some implementations, the liquid flow sensing sheet is circular with a notch, and at least part of the notch of the liquid flow sensing sheet faces toward the side of the electromagnetic shielding part.

In some embodiments, an insulating sleeve is provided at the opening of the first through hole, the central through hole of the insulating sleeve is coaxial with the outlet of the liquid injection tube, and the annular liquid The flow induction sheet is set on the outer peripheral wall of the insulating sleeve.

In some embodiments, the arc length of the notch is s, the circumference of the circular ring is L, and 1/2<s/L≦1/4.

In some embodiments, the reagent strip reagent leakage detection device further includes an assembly bracket, the assembly bracket includes a T-shaped beam, and the T-shaped beam includes a beam and a longitudinal beam. The detection assembly has two groups, two groups The detection components are symmetrically assembled on both ends of the cross beam with respect to the longitudinal beam.

In some embodiments, the reagent strip reagent leakage detection device further includes a control box, the control box is connected to the assembly bracket, and the control board is accommodated in the control box; and/ Alternatively, the assembly bracket can be driven to reciprocate linearly along a direction perpendicular to the length direction of the reagent strip.

In some embodiments, a liquid injection block is formed on the side of the loading box away from the first through hole, and the liquid injection block can be positioned at the outlet end of the liquid injection tube; and/or, the A pipeline fixing block is connected to the outer wall of the control box, and the pipeline fixing block can fix the area of the liquid injection pipe away from the outlet.

The invention provides a reagent leakage detection device for reagent strips. The non-contact liquid flow sensing component can detect whether the reagent liquid flows through the second through hole in a non-contact manner. The judgment of liquid leakage has no adverse effects on the reagent liquid caused by the optical detection method, and is more accurate than the detection result of the quality detection method. At the same time, no manual judgment is required, the detection sensitivity is higher and the detection result is more reliable.

Description of drawings

Fig. 1 is the three-dimensional structure schematic diagram (containing reagent strip) of the reagent strip reagent leakage detection device of the embodiment of the present invention;

Fig. 2 is the schematic diagram of the exploded structure of the reagent strip reagent leakage detection device in Fig. 1;

3 is a three-dimensional schematic diagram of a reagent strip reagent leakage detection device (including a reagent strip and a reagent strip holder) according to another embodiment of the present invention;

Fig. 4 is a schematic diagram of the three-dimensional structure of some components of a reagent leak detection device for reagent strips according to another embodiment of the present invention.

The reference signs are indicated as:

1. Loading box; 11. Electromagnetic shielding part; 12. Liquid injection block; 21. Liquid flow sensor; 22. Control panel; 23. Insulation sleeve; 3. Liquid injection pipe; 41. T-beam; 5. Control Box body; 51, pipeline fixing block; 100, reagent strip; 101, reagent hole; 102, reagent strip holder.

Detailed ways

Referring to Figures 1 to 4, according to an embodiment of the present invention, a reagent strip reagent leakage detection device is provided, including a detection component, the detection component has a loading box body 1, a non-contact liquid flow sensing component, and the loading box The body 1 has a first through hole that can correspond to the reagent hole 101 of the reagent strip 100. The non-contact liquid flow sensing component includes a liquid flow sensing sheet 21 and a control board 22, wherein the control board 22 has a frequency synthesizer, The frequency synthesizer has an extension line, and the extension line is electrically connected to the liquid flow induction sheet 21, and the liquid flow induction sheet 21 is arranged corresponding to the orifice of the first through hole, and the liquid flow induction sheet 21 is configured with a second through hole, and the second through hole A liquid injection pipe 3 is suspended at the side opening away from the first through hole, and the outlet of the liquid injection pipe 3, the first through hole and the second through hole are coaxially arranged, and the control board 22 is equipped with The detection circuit, the detection circuit can judge whether there is reagent liquid flowing through the second through hole according to the output signal of the frequency synthesizer. It should be noted that although the outlet of the injection tube 3, the first through hole and the second The two through-holes and the three are arranged coaxially, but it does not mean that the three are strictly coaxial. In theory, as long as the reagent liquid flowing out of the outlet can be filled into the corresponding through-hole through the second through-hole and the first through-hole The arrangement of the reagent wells 101 is the technical solution to be protected in the present invention. Of course, in an ideal state, it is better for the three to be arranged strictly coaxially.

In this technical scheme, when there is a liquid flow through the second through hole of the liquid flow sensing sheet 21, the capacitance of this component and the extension line electrically connected to it will change, causing the input voltage on the frequency synthesizer to change, Then the frequency synthesizer outputs a frequency and compares it with the standard frequency. When the two frequencies are the same, a pulse signal is output to the corresponding interface of the control board 22, and the detection circuit judges according to the corresponding pulse signal, that is, the output signal of the frequency synthesizer. Whether there is reagent liquid flowing through the second through hole.

The non-contact liquid flow sensing component detects whether the reagent liquid flows through the second through hole in a non-contact manner, and can use the change in capacitance to realize the judgment of the leakage of the reagent liquid in the reagent hole 101, without the inconvenience caused by the optical detection method. The adverse effect on the reagent liquid is also more accurate than the detection result of the quality detection method, and at the same time, no manual judgment is required, the detection sensitivity is higher and the detection result is more reliable.

It should be noted that the above-mentioned non-contact liquid flow sensing component can be realized by using relevant detection components with frequency synthesizers on the market. The realization principle is well known, and the present invention does not intend to protect it. The key to improvement is to apply this existing non-contact detection technology to the phenomenon of reagent leakage during the reagent filling process, and then realize the judgment of this phenomenon through the aforementioned different states, so that the technology of the present invention The scheme is different from the way of detecting and judging reagent leakage in the prior art.

In order to prevent external electromagnetic waves from interfering with the aforementioned liquid flow sensing sheet 21, and at the same time prevent possible electromagnetic interference from the liquid flow sensing sheet 21 to external components, the material of the loading box body 1 is an electromagnetic shielding material. For example, the loading box body 1 can be It is directly made of metal such as stainless steel, so that it has the rigidity and structural strength as an assembly carrier. In another embodiment, the aforementioned electromagnetic wave shielding and anti-interference can also be achieved by setting an electromagnetic shielding layer on the outside of the loading box 1. Effect.

In some embodiments, there are a plurality of first through holes on the loading box body 1, and the plurality of first through holes are arranged at intervals along the first direction. The reagent hole 101 of the lower reagent strip 100 is adapted, and each first through hole is respectively provided with a liquid flow sensing piece and a liquid injection tube 3, so that for the filling of a reagent strip 100, only one position can be used. Complete, the filling efficiency has been greatly improved.

At this time, in order to prevent mutual interference between two adjacent liquid flow sensing sheets 21, an electromagnetic shielding part 11 is also provided in the loading box body 1, and the electromagnetic shielding part 11 is located between the two adjacent liquid flow sensing sheets 21. space, so that electromagnetic interference between two adjacent liquid flow sensing sheets 21 can be eliminated.

In a preferred embodiment, as shown in FIG. 4 , the liquid flow sensing sheet 21 is circular with a gap, and at least part of the gap of the liquid flow sensing sheet 21 faces the side of the electromagnetic shielding part 11, and the gap penetrates the liquid The axial ends of the flow sensing sheet 21 make the circular ring into an incomplete circular ring, so that the center distance between two adjacent liquid flow sensing sheets 21 can be the same as that of the adjacent ones on the same reagent strip 100. While the distance between the two reagent holes 101 is matched, the electromagnetic shielding part 11 can also have enough layout space to effectively prevent electromagnetic interference between two adjacent liquid flow sensing sheets 21 and ensure the reliability of the detection results. and accurate.

In some embodiments, the arc length of the notch is s, the circumference of the circular ring is L, 1/2<s/L≤1/4, so that the liquid flow sensing sheet 21 is formed into a superior arc shape in appearance In a preferred embodiment, an insulating sleeve 23 is provided at the opening of the first through hole, and the central through hole of the insulating sleeve 23 is coaxial with the outlet of the injection pipe 3, and The circular liquid flow induction piece 21 is set on the outer peripheral wall of the insulating sleeve 23, so that the distance between each adjacent liquid flow induction piece 21 can be adapted to the distance between the adjacent reagent holes 101, and the superior arc shape can also be used. The structure enables the liquid flow sensing piece 21 to be reliably connected to the outer peripheral wall of the insulating sleeve 23 by way of interference fit, without special positioning of the liquid flow sensing piece 21 .

Referring to Fig. 3, in another embodiment, the reagent strip reagent leakage detection device also includes an assembly bracket (not labeled in the figure), the assembly bracket includes a T-shaped beam 41, and the T-shaped beam includes a crossbeam and a longitudinal beam. There are two groups of components, and the two groups of detection components are symmetrically assembled on both ends of the beam with respect to the longitudinal beam, that is, the detection device has two detection components, which can simultaneously test each reagent hole 101 on two reagent strips 100 at one time. Filling, to further improve the efficiency of reagent filling. In a preferred embodiment, the assembly bracket can be driven to reciprocate linearly along a direction perpendicular to the length direction of the reagent strip 100 (that is, the aforementioned first direction), so that the position of each detection component relative to the reagent strip 100 can be changed. The relative position realizes the reagent filling of different reagent strips 100 .

Referring to Fig. 3, the reagent strip reagent leakage detection device also includes a control box 5, the control box 5 is connected to the assembly bracket, and the control board 22 is accommodated in the control box 5, specifically, the control box 5 The quantity is also matched with the number of detection components and arranged in one-to-one correspondence, and the control boards 22 corresponding to each liquid flow sensing plate 21 in each detection component are all placed in the corresponding control box 5, and the structure is more compact.

A liquid injection block 12 is formed on the side of the loading box body 1 away from the first through hole. The liquid injection block 12 can position the outlet end of the liquid injection pipe 3 to form a position for the end of each liquid injection pipe 3 to prevent outflow. The position between the opening and the first through hole is changed to ensure the reliable filling of the reagent liquid; the outer wall of the control box 5 is connected with a pipeline fixing block 51, and the pipeline fixing block 51 can fix the injection pipe 3 away from the outlet. The area of the orifice optimizes and stabilizes the pipeline layout and prevents the pipeline from being entangled during the movement of the device.

The reagent strip reagent leakage detection device of the present invention has a simple and compact overall structure and occupies less space.

Those skilled in the art can easily understand that, on the premise of no conflict, the above-mentioned advantageous modes can be freely combined and superimposed.

The above are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention. Inside. The above are only preferred embodiments of the present invention, it should be pointed out that for those of ordinary skill in the art, without departing from the technical principles of the present invention, some improvements and modifications can also be made, and these improvements and modifications should also be It is regarded as the protection scope of the present invention.

Claims (10)

1. The reagent strip reagent leakage irrigation detection device is characterized by comprising a detection assembly, wherein the detection assembly is provided with a loading box body (1) and a non-contact liquid flow induction assembly, a first through hole corresponding to a reagent hole (101) of a reagent strip (100) is formed in the loading box body (1), the non-contact liquid flow induction assembly comprises a liquid flow induction sheet (21) and a control panel (22), a frequency synthesizer is arranged on the control panel (22), the frequency synthesizer is provided with an extension line, the extension line is electrically connected with the liquid flow induction sheet (21), a second through hole is constructed in the liquid flow induction sheet (21), a liquid injection pipe (3) is suspended at a hole at one side of the second through hole, which deviates from the first through hole, a flow outlet of the liquid injection pipe (3), the first through hole and the second through hole are coaxially arranged, a detection circuit is configured in the control panel (22), and the detection circuit can judge whether reagent liquid flows through the second through hole according to an output signal of the frequency synthesizer.

2. The reagent strip reagent leakage irrigation detection device of claim 1, wherein the material of the loading box body (1) is an electromagnetic shielding material or the loading box body (1) is provided with an electromagnetic shielding layer.

3. The reagent strip reagent leakage irrigation detection device according to claim 2, wherein the first through holes on the loading box body (1) are provided in a plurality, the first through holes are arranged at intervals along a first direction, and the non-contact liquid flow sensing piece and the liquid injection pipe (3) are respectively arranged in the first through holes correspondingly.

4. The reagent strip reagent leakage irrigation detection device according to claim 2, wherein the loading box body (1) is provided with an electromagnetic shielding part (11), and the electromagnetic shielding part (11) is arranged between two adjacent liquid flow induction sheets (21).

5. The reagent strip reagent leakage detection device according to claim 4, wherein the liquid flow induction sheet (21) is in a ring shape with a notch, and the notch of at least a part of the liquid flow induction sheet (21) faces one side of the electromagnetic shielding part (11).

6. The reagent strip reagent leakage irrigation detection device according to claim 5, wherein an insulating sleeve (23) is arranged at the orifice of the first through hole, the central through hole of the insulating sleeve (23) is coaxial with the outflow port of the injection tube (3), and the annular liquid flow sensing piece (21) is sleeved on the outer circumferential wall of the insulating sleeve (23).

7. The reagent strip reagent leakage irrigation detection device of claim 6, wherein the arc length of the notch is s, the circumference of the circular ring is L, and s/L is more than 1/2 and less than or equal to 1/4.

8. The reagent strip reagent leakage irrigation detection device of claim 1 further comprising an assembly bracket, wherein the assembly bracket comprises a T-shaped beam (41), the T-shaped beam comprises a cross beam and a longitudinal beam, the detection assemblies are provided in two groups, and the two groups of detection assemblies are respectively assembled at two ends of the cross beam symmetrically relative to the longitudinal beam.

9. The reagent strip reagent leakage irrigation detection device of claim 8, further comprising a control box body (5), wherein the control box body (5) is connected to the assembly bracket, and the control plate (22) is accommodated in the control box body (5); and/or the assembly bracket can be driven to linearly reciprocate along the direction vertical to the length direction of the reagent strip (100).

10. The reagent strip reagent leakage perfusion detection device according to claim 9, wherein a liquid injection block (12) is formed on one side of the loading box body (1) far away from the first through hole, and the liquid injection block (12) can be positioned at one end of an outflow port of the liquid injection pipe (3); and/or, the outer side wall of the control box body (5) is connected with a pipeline fixing block (51), and the pipeline fixing block (51) can fix the area of the liquid injection pipe (3) far away from the outflow port.

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