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CN1158265C - Quinoline ketone derivant and antianaphylaction using same as active substance - Google Patents

Quinoline ketone derivant and antianaphylaction using same as active substance Download PDF

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CN1158265C
CN1158265C CNB001064266A CN00106426A CN1158265C CN 1158265 C CN1158265 C CN 1158265C CN B001064266 A CNB001064266 A CN B001064266A CN 00106426 A CN00106426 A CN 00106426A CN 1158265 C CN1158265 C CN 1158265C
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quinolinone
methyl
nitro
amino
methoxy
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CN1275564A (en
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高垣秀次
阿部真好
酒井充
青木康夫
֮
中西滋典
木村信之
江田昭英
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Mar Rip SA Health Ltd
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Dainippon Ink and Chemicals Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

The present invention offers 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, anti-allergic agents having as an active ingredient a 7-aminoquinolinone derivative or physiologically acceptable salt thereof, and 7-nitroquinolinone derivatives, wherein the 7-aminoquinolinone derivative is expressed by the following general formula (I): wherein R1 is a hydrogen atom or an alkyl group; R2 and R3 are mutually different groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups or alkenyl groups; and R4 and R5 are mutually different or identical groups, each of which is selected from among hydrogen atoms, acyl groups, alkyl groups, alkenyl groups or aralkyl groups; and physiologically acceptable salts thereof.

Description

喹啉酮衍生物以及含有所述喹啉酮 衍生物作活性成分的抗过敏剂Quinolinone derivatives and antiallergic agents containing said quinolinone derivatives as active ingredients

本发明涉及新颖的7-氨基喹啉酮衍生物及其生理学上可接受的盐类，它们可有效地治疗或抑制过敏性疾病，并涉及合成所述7-氨基喹啉酮衍生物的中间体7-硝基喹啉酮衍生物，还涉及含有所述7-氨基喹啉酮衍生物以及其生理学上可接受的盐类作为活性成分的抗过敏剂。The present invention relates to novel 7-aminoquinolinone derivatives and physiologically acceptable salts thereof, which can effectively treat or inhibit allergic diseases, and to intermediates for synthesizing said 7-aminoquinolinone derivatives The 7-nitroquinolinone derivative also relates to an antiallergic agent containing the 7-aminoquinolinone derivative and its physiologically acceptable salts as active ingredients.

关于氧原子直接在3-和4-位上键合的喹啉酮衍生物，下面列出了一些文献中公开的化合物。Regarding quinolinone derivatives in which oxygen atoms are directly bonded at the 3- and 4-positions, some compounds disclosed in literature are listed below.

首先，作为喹啉酮含氮环上3-和4-位具有取代基，而芳香基团上缺乏取代基团的喹啉酮化合物，3-甲氧基-4-羟基-2(1H)-喹啉酮，3-乙氧基-4-羟基-2(1H)-喹啉酮及3，4-二羟基-2(1H)-喹啉酮的红外吸收光谱于 Monatsh.Chem.，98(1)，pp.100 -104，1967中被披露。First, as a quinolinone compound that has substituents at the 3- and 4-positions on the nitrogen-containing ring of quinolinone and lacks substituents on the aromatic group, 3-methoxy-4-hydroxyl-2(1H)- The infrared absorption spectrum of quinolinone, 3-ethoxy-4-hydroxyl-2 (1H)-quinolinone and 3,4-dihydroxyl-2 (1H)-quinolinone is in Monatsh.Chem., 98 ( 1), pp.100-104 , 1967 are disclosed .

Monatsh.Chem.，99(6)，pp.2157-2166，1968中也公开了制备3，4-二羟基-2(1H)-喹啉酮及3，4-二羟基-1-苯基-2(1H)-喹啉酮的方法。 Monatsh.Chem., 99(6), pp.2157-2166, 1968 also discloses the preparation of 3,4-dihydroxy-2(1H)-quinolinone and 3,4-dihydroxy-1-phenyl- 2(1H)-Quinolinone Method.

另外， Liebigs Ann.Chem.，9，pp.1545-1551，1973公开了制备3，4-二羟基-1-苯基-2(1H)-喹啉酮和3，4-二乙酰氧基-1-苯基-2(1H)-喹啉酮的方法。In addition, Liebigs Ann. Chem., 9, pp.1545-1551, 1973 discloses the preparation of 3,4-dihydroxy-1-phenyl-2(1H)-quinolinone and 3,4-diacetoxy- 1-Phenyl-2(1H)-quinolinone method.

进一步而言， Chem.Ber.106，pp.1537-1548，1973公开了制备3，4-二羟基-1-甲基-2(1H)-喹啉酮的方法，并且 Z.Natur- forsch.，B；Anorg.Chem.Org.Chem.，33B(4)pp.429-432，1978公开了制备3，4-二羟基-1-苯基-2(1H)-喹啉酮的方法。Further, Chem.Ber.106, pp.1537-1548, 1973 discloses a method for preparing 3,4-dihydroxy-1-methyl-2(1H)-quinolinone, and Z.Natur- forsch. , B; Anorg.Chem.Org.Chem., 33B(4)pp.429-432, 1978 discloses a method for preparing 3,4-dihydroxy-1-phenyl-2(1H)-quinolinone.

Monatsh.Chem.，115(2)，pp.231-242，1984公开了制备3，4-二羟基-2(1H)-喹啉酮，3-甲氧基-4-羟基-2(1H)-喹啉酮，3-乙氧基-4-羟基-2(1H)-喹啉酮，3-丙氧基-4-羟基-2(1H)-喹啉酮，3-三氟乙酰氧基-4-羟基-2(1H)-喹啉酮，3-乙酰氧基-4-羟基-2(1H)-喹啉酮，3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮以及3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮的方法。 Monatsh.Chem., 115(2), pp.231-242, 1984 discloses the preparation of 3,4-dihydroxy-2(1H)-quinolinone, 3-methoxy-4-hydroxyl-2(1H) -quinolinone, 3-ethoxy-4-hydroxy-2(1H)-quinolinone, 3-propoxy-4-hydroxy-2(1H)-quinolinone, 3-trifluoroacetoxy -4-hydroxyl-2(1H)-quinolinone, 3-acetoxy-4-hydroxyl-2(1H)-quinolinone, 3-acetoxyl-4-hydroxyl-1-methyl-2( 1H)-quinolinone and 3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone methods.

Phosphorus and Sulfur，21(1)，pp.47-52，1984公开了3，4-二羟-2(1H)-喹啉酮3-二甲基磷酸盐，3-羟基-4-甲氧基-2(1H)-喹啉酮3-二甲基磷酸盐，3，4-二羟基-2(1H)-喹啉酮3-二乙基磷酸盐，3，4-二羟基-2(1H)-喹啉酮3-二异丙基磷酸盐以及这些化合物的N-甲基化合物。 Phosphorus and Sulfur, 21(1), pp.47-52, 1984 disclosed 3,4-dihydroxy-2(1H)-quinolinone 3-dimethylphosphate, 3-hydroxyl-4-methoxy -2(1H)-quinolinone 3-dimethylphosphate, 3,4-dihydroxy-2(1H)-quinolinone 3-diethylphosphate, 3,4-dihydroxy-2(1H )-quinolinone 3-diisopropylphosphate and the N-methyl compounds of these compounds.

FEBS Lett.246(1-2)，pp.113-116，1989公开了制备3，4-二羟基-2(1H)-喹啉酮的方法。 FEBS Lett. 246(1-2), pp. 113-116, 1989 discloses a process for the preparation of 3,4-dihydroxy-2(1H)-quinolinones.

Phyto Chemistry，28(5)，p.1517-1519，1989公开了作为Clausena anisata提取物的3，4-二甲氧基-2(1H)-喹啉酮以及3，4-二甲氧基-1-甲基-2(1H)-喹啉酮。 Phyto Chemistry, 28(5), p.1517-1519, 1989 disclosed 3,4-dimethoxy-2(1H) -quinolinone and 3,4-dimethoxy- 1-Methyl-2(1H)-quinolinone.

关于在喹啉酮芳烃环上具有取代基团的化合物， Indian J. Chem.，Sect.B，15B(5)，pp.440-444，1977公开了3，4-二甲氧-2(1H)-喹啉酮，8-甲氧基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮及其甲基醚，作为得自 Chloroxylon Swietenia DC树皮的化合物：8-甲氧基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮。Regarding compounds having substituent groups on the quinolinone arene ring, Indian J. Chem., Sect.B, 15B(5), pp.440-444, 1977 discloses 3,4-dimethoxy-2(1H )-quinolinone, 8-methoxy-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone and its methyl ether, as obtained from the bark of Chloroxylon Swietenia DC Compound: 8-methoxy-3,4-dimethoxy-1-methyl-2(1H)-quinolinone.

另外， Indian J.Chem.，Sect.B，22B(12)，pp.1254-1256，1983公开了制备8-甲氧基-3-甲氧基-4-羟基-2(1H)-喹啉酮以及8-甲氧基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮的方法。Additionally, Indian J.Chem., Sect.B, 22B(12), pp.1254-1256, 1983 discloses the preparation of 8-methoxy-3-methoxy-4-hydroxy-2(1H)-quinoline Ketone and 8-methoxy-3,4-dimethoxy-1-methyl-2(1H)-quinolinone.

另外， J.Heterocyclic Chem.，22，1985公开了制备3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮以及8-甲氧基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮的方法。In addition, J.Heterocyclic Chem., 22, 1985 discloses the preparation of 3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone and 8-methoxy-3-methoxy- 4-Hydroxy-1-methyl-2(1H)-quinolinone method.

Journal of Natural Products，58(4)，pp.574-576，1995公开了作为得自 Eriostemon gardneri成份的8-甲氧基-3，4-二羟基-2(1H)-喹啉酮。然后正如上述的，对于喹啉酮衍生物的芳环而言，仅有甲氧基是已知的取代基团。 Journal of Natural Products, 58(4), pp.574-576, 1995 discloses 8-methoxy-3,4-dihydroxy-2(1H)-quinolinone as a component from Eriostemon gardneri . However, as mentioned above, only methoxy is a known substituent for the aromatic rings of quinolinone derivatives.

另外，美国专利编号5,378,694(相应于WO92/04,328以及相当于日本专利申请，第二版，序号Hei6-502,845)描述了具有3-位羰基取代基以及4-位羟基(或烷氧基)取代基的喹啉酮衍生物，并描述了这些化合物的抗病毒活性及抗高血压活性。In addition, U.S. Patent No. 5,378,694 (corresponding to WO92/04,328 and equivalent to Japanese Patent Application, Second Edition, Serial No. Hei6-502,845) describes a carbonyl substituent at the 3-position and a hydroxyl (or alkoxyl) substituent at the 4-position quinolinone derivatives and describe the antiviral and antihypertensive activity of these compounds.

另外，美国专利编号5,412,104(相应于WO92/04327)及相当于日本专利申请，第二次公开，号Hei7-110,853)描述了具有3-位含有羰基取代基团，4-位为烷氧基团，羰氧基团或氨基基团的喹啉酮衍生物以及这些化合物的抗病毒活性；欧洲专利号码459,561A2公开了2，4-二氧代四氢喹啉衍生物，其中3-位取代基为含羰基的取代基团，4-位为一可变的4-酮。In addition, U.S. Patent No. 5,412,104 (corresponding to WO92/04327) and equivalent Japanese Patent Application, Second Publication, No. Hei7-110,853) describe substituents having a carbonyl group at the 3-position and an alkoxy group at the 4-position , quinolinone derivatives of carbonyloxy group or amino group and the antiviral activity of these compounds; European Patent No. 459,561A2 discloses 2,4-dioxotetrahydroquinoline derivatives, wherein the 3-position substituent It is a carbonyl-containing substituent group, and the 4-position is a variable 4-ketone.

欧洲专利申请(公开号为481,676A1)公开了3-位带有取代的芳基基团、4位为羟基的喹啉酮衍生物；US专利(号为4,124,587)公开了3位为亚磺酰基团、4位为羟基基团的喹啉酮衍生物；US专利(号码为4,127,574)公开了3位为磺酰基团、4位为羟基的喹啉酮衍生物。European Patent Application (Publication No. 481,676A1) discloses quinolinone derivatives with a substituted aryl group at the 3-position and a hydroxyl group at the 4-position; US Patent (No. 4,124,587) discloses a sulfinyl group at the 3-position A quinolinone derivative with a sulfonyl group and a hydroxyl group at the 4-position; US Patent (No. 4,127,574) discloses a quinolinone derivative with a sulfonyl group at the 3-position and a hydroxyl group at the 4-position.

欧洲专利申请(公开号为685,466A1)公开了3位为硫化物基团、4位为羟基基团的喹啉酮衍生物，WO96/04288公开了5，7-二甲基-4-羟基-2(1H)-喹啉酮以及5，7-二氯-4-羟基-2(1H)-喹啉酮。European Patent Application (publication number is 685,466A1) discloses quinolinone derivatives whose 3-position is a sulfide group and the 4-position is a hydroxyl group, and WO96/04288 discloses 5,7-dimethyl-4-hydroxyl- 2(1H)-quinolinone and 5,7-dichloro-4-hydroxy-2(1H)-quinolinone.

进一步地，US专利(号5,179,107)和US专利(号5,190,956)对一大批在芳香环上带有取代基的，及3-和4-位上直接与氧相连的喹啉酮衍生物作了摘要性的描述。但是该美国专利没有披露具有与7-位键合的取代基如氨基或硝基的本发明喹啉酮衍生物。Further, US Patent (No. 5,179,107) and US Patent (No. 5,190,956) have abstracted a large number of quinolinone derivatives that have substituents on the aromatic ring and are directly connected to oxygen at the 3- and 4-positions sexual description. However, this US patent does not disclose the quinolinone derivatives of the present invention having substituents such as amino or nitro groups bonded to the 7-position.

这些US专利申请公开了具有下述特征的喹啉酮衍生物，即3-位和4-位上的取代基团是相同的，并且指出这些化合物具有抗病毒活性。但这些美国专利既没有披露具有与7-位键合的氨基的本发明喹啉酮衍生物也没有披露它们的抗过敏活性。These US patent applications disclose quinolinone derivatives characterized in that the substituent groups at the 3-position and 4-position are the same and indicate that these compounds have antiviral activity. But these US patents disclose neither the quinolinone derivatives of the present invention having an amino group bonded to the 7-position nor their antiallergic activity.

另一方面，人们已知许多抗过敏剂仅仅对即发型过敏(即I型过敏)有效，几乎没有报道表明抗过敏剂对迟发型过敏有效。然而，在各种类型的过敏疾病中，迟发型过敏是较难对付的一种过敏疾病，因此临床上使用甾体类化合物来对付迟发型过敏。On the other hand, many antiallergic agents are known to be effective only for immediate hypersensitivity (ie type I allergy), and there are few reports showing that antiallergic agents are effective for delayed hypersensitivity. However, in various types of allergic diseases, delayed hypersensitivity is a kind of allergic disease that is more difficult to deal with, so steroids are used clinically to deal with delayed hypersensitivity.

尽管甾体类化合物给出了很强的治疗效果，但其也有严重的副作用，例如消化道溃疡，易感染，生理性紊乱，甾类物性糖尿，多毛(症)，满月脸，骨质疏松(骨头变得很脆)以及肥胖。由于这些原因，临床上必须严格限制其使用，并需要有医生的严格指导。Although steroids give a strong therapeutic effect, they also have serious side effects, such as peptic ulcer, susceptibility to infection, physiological disorder, steroidal diabetes, hirsutism, moon face, osteoporosis ( bones become brittle) and obesity. For these reasons, its use must be strictly limited clinically, and strict guidance from doctors is required.

因此，甾体化合物在很大程度上仅作为外用药物来治疗轻度皮肤过敏疾病，当它们用于治疗一般性的过敏性疾病时，特别是迟发型过敏疾病时，是受到严格限制的。因此很有必要去发展一种既能有效对付即发型和迟发型过敏，又具有较少副作用的药物。Therefore, steroids are only used as external drugs to treat mild skin allergy diseases to a large extent, and when they are used to treat general allergic diseases, especially delayed-type allergic diseases, they are strictly limited. Therefore, it is necessary to develop a drug that can effectively deal with immediate and delayed allergies, and has less side effects.

综上所述，具有7-位氨基取代基的喹啉酮衍生物和作为其俣成中间体的7-硝基喹啉酮衍生物是未知的。进一步讲，7-氨基喹啉酮衍生物或其药用盐作为有效抗即发型过敏性疾病和延迟型过敏性疾病的抗过敏药物而几乎没有副作用也是未知的。In summary, quinolinone derivatives having an amino substituent at the 7-position and 7-nitroquinolinone derivatives as intermediates for their synthesis are unknown. Further, 7-aminoquinolinone derivatives or pharmaceutically acceptable salts thereof are also unknown as antiallergic drugs effective against immediate allergic diseases and delayed allergic diseases with few side effects.

本发明的目标是提供新颖的硝基喹啉酮衍生物，由这些硝基喹啉酮衍生物合成而得的氨基喹啉酮衍生物，以及它们生理学上可接受的盐类，并且提供具有这些氨基喹啉酮衍生物以及生理学上可接受的盐类作为活性成分的极其安全的药物，尤其是可有效地对付即发型过敏疾病和迟发型过敏疾病的抗过敏剂。The object of the present invention is to provide novel nitroquinolinone derivatives, aminoquinolinone derivatives synthesized by these nitroquinolinone derivatives, and their physiologically acceptable salts, and to provide Aminoquinolinone derivatives and physiologically acceptable salts are extremely safe medicines as active ingredients, especially antiallergic agents that can effectively deal with immediate allergic diseases and delayed allergic diseases.

本发明其它目的包括将氨基喹啉酮衍生物或其药用盐作为活性成份用于过敏性疾病。本发明还提供了将上述抗过敏药物用于过敏性疾病。本发明还提供了用硝基喹啉酮衍生物作为中间体用于制备氨基喹啉酮衍生物或其药用盐，或用于制备上述抗过敏药。Other objects of the present invention include the use of aminoquinolinone derivatives or pharmaceutically acceptable salts thereof as active ingredients for allergic diseases. The present invention also provides the use of the above-mentioned antiallergic drugs for allergic diseases. The present invention also provides the use of nitroquinolinone derivatives as intermediates for the preparation of aminoquinolinone derivatives or pharmaceutically acceptable salts thereof, or for the preparation of the aforementioned antiallergic drugs.

为了实现上述目标，本发明者合成了许多化合物，评价了它们的药用有效性和安全性。结果他们成功地合成了在芳香环上带有硝基基团作为取代基的7-硝基喹啉酮衍生物，然后进一步成功地由这个化合物合成了带有氨基基团的7-氨基喹啉酮衍生物，并且作为一种抗过敏剂，发现7-氨基喹啉酮衍生物是极其有效的，从而完成了本发明。In order to achieve the above objects, the present inventors synthesized many compounds and evaluated their medicinal effectiveness and safety. As a result, they successfully synthesized 7-nitroquinolinone derivatives with nitro groups as substituents on the aromatic ring, and then further successfully synthesized 7-aminoquinolines with amino groups from this compound Ketone derivatives, and found that 7-aminoquinolinone derivatives are extremely effective as an antiallergic agent, thereby completing the present invention.

本发明提供了7-氨基喹啉酮衍生物，其生理学上可接受的盐类，具有7-氨基喹啉酮衍生物或其生理学上可接受的盐类作为活性成分的抗过敏剂，以及7-硝基喹啉酮衍生物，下文将作更详细的描述。The present invention provides 7-aminoquinolinone derivatives, physiologically acceptable salts thereof, antiallergic agents having 7-aminoquinolinone derivatives or physiologically acceptable salts thereof as active ingredients, and 7 - Nitroquinolinone derivatives, described in more detail below.

(1)7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其可用下式(I)表示：(1) 7-aminoquinolinone derivatives and physiologically acceptable salts, which can be represented by the following formula (I):

Figure C0010642600071
Figure C0010642600071

其中in

R1为氢原子或烷基基团；R 1 is a hydrogen atom or an alkyl group;

R2和R3互为不相同的基团，每个基团选自氢原子，酰基基团，烷基基团或链烯基基团；且 R2 and R3 are mutually different groups, each group is selected from a hydrogen atom, an acyl group, an alkyl group or an alkenyl group; and

R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，烷基基团，链烯基基团或芳烷基团。R 4 and R 5 are mutually different or identical groups, and each group is selected from a hydrogen atom, an acyl group, an alkyl group, an alkenyl group or an aralkyl group.

(2)按照上述(1)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R1为氢原子或具1-10个碳原子的直链或支链的烷基基团。(2) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (1), R is a hydrogen atom or a linear or branched alkane with 1-10 carbon atoms base group.

(3)按照上述(1)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3分别为氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(3) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (1), R2 and R3 are respectively hydrogen atoms and acyl groups, with 1-10 carbon atoms straight-chain or branched-chain alkyl groups or straight-chain or branched-chain alkenyl groups having 2-10 carbon atoms.

(4)按照上述(1)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(4) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (1), R and R are mutually different or identical groups, and each group is selected from Hydrogen atom, acyl group, straight-chain or branched alkyl group with 1-10 carbon atoms, straight-chain or branched alkenyl group or aralkyl group with 2-10 carbon atoms .

(5)按照上述(1)至(4)中的任何一个7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R1为氢原子或具1-10个碳原子的直链或支链的烷基基团；R2和R3分别为氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团或具有2-10个碳原子的直链或支链的链烯基基团；R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，具有1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(5) According to any one of the above-mentioned (1) to (4) 7-aminoquinolinone derivatives and physiologically acceptable salts, wherein, R 1 is a hydrogen atom or a straight line with 1-10 carbon atoms Chain or branched alkyl groups; R2 and R3 are hydrogen atoms, acyl groups, linear or branched alkyl groups with 1-10 carbon atoms or 2-10 carbon atoms A linear or branched alkenyl group; R 4 and R 5 are mutually different or identical groups, each group is selected from a hydrogen atom, an acyl group, a straight chain having 1-10 carbon atoms A chain or branched alkyl group, a straight or branched alkenyl group or an aralkyl group having 2 to 10 carbon atoms.

(6)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是氢原子，R3为具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(6) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (5), wherein, R 2 is a hydrogen atom, R 3 is a straight chain or branched chain with 1-10 carbon atoms chain alkyl group or straight or branched alkenyl group having 2-10 carbon atoms.

(7)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是酰基基团，且R3为氢原子。(7) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (5) above, wherein R 2 is an acyl group, and R 3 is a hydrogen atom.

(8)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是酰基基团，且R3为具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(8) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (5), R 2 is an acyl group, and R 3 is a straight chain with 1-10 carbon atoms Or a branched alkyl group or a straight or branched alkenyl group with 2-10 carbon atoms.

(9)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团，且R3为氢原子。(9) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (5), R2 is a linear or branched alkyl group with 1-10 carbon atoms Or a linear or branched alkenyl group with 2-10 carbon atoms, and R 3 is a hydrogen atom.

(10)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团，且R3为酰基基团。(10) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (5), R2 is a linear or branched alkyl group with 1-10 carbon atoms Or a linear or branched alkenyl group with 2-10 carbon atoms, and R 3 is an acyl group.

(11)按照上述(5)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3互为不相同的具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(11) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (5), wherein, R2 and R3 are different linear or 1-10 carbon atoms A branched alkyl group or a straight or branched alkenyl group having 2 to 10 carbon atoms.

(12)按照上述(6)至(11)中任意一个7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R4为氢原子，R5为氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(12) According to any one of the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (6) to (11), wherein, R 4 is a hydrogen atom, R 5 is a hydrogen atom, an acyl group, A straight-chain or branched alkyl group having 1-10 carbon atoms, a straight-chain or branched alkenyl group or an aralkyl group having 2-10 carbon atoms.

(13)按照上述(12)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为酰基基团。(13) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (12) above, wherein R 5 is an acyl group.

(14)按照上述(13)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为由肉桂基(其上可有取代基)组成的酰基基团。(14) The 7-aminoquinolinone derivative and the physiologically acceptable salts according to (13) above, wherein R 5 is an acyl group consisting of a cinnamyl group (which may have a substituent).

(15)按照上述(14)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为4-羟基-3-甲氧基肉桂基基团或3，5-二甲氧基-4羟基肉桂基基团。(15) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (14), R 5 is 4-hydroxy-3-methoxycinnamyl group or 3,5- Dimethoxy-4 hydroxycinnamyl group.

(16)按照上述(1)至(15)中任何一个的7-氨基喹啉酮衍生物以及生理学上可接受的盐类作为活性成份的抗过敏剂。(16) An antiallergic agent having a 7-aminoquinolinone derivative and a physiologically acceptable salt according to any one of the above (1) to (15) as an active ingredient.

(17)7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其可用下式(I)表示：(17) 7-aminoquinolinone derivatives and physiologically acceptable salts, which can be represented by the following formula (I):

其中in

R1为氢原子或一个具1-10个碳原子的直链或支链的烷基基团；R 1 is a hydrogen atom or a linear or branched alkyl group with 1-10 carbon atoms;

R2和R3为相同的基团，每个基团选自氢原子，烷基基团或链烯基基团；且R and R are the same group, each selected from a hydrogen atom, an alkyl group or an alkenyl group; and

R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，烷基基团，链烯基基团或芳烷基团。R 4 and R 5 are mutually different or identical groups, and each group is selected from a hydrogen atom, an acyl group, an alkyl group, an alkenyl group or an aralkyl group.

(18)按照上述(17)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3为氢原子，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(18) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (17), wherein, R 2 and R 3 are hydrogen atoms, straight chain or branched with 1-10 carbon atoms chain alkyl group or straight or branched alkenyl group having 2-10 carbon atoms.

(19)按照上述(17)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(19) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (17), R4 and R5 are mutually different or identical groups, and each group is selected from Hydrogen atom, acyl group, straight-chain or branched alkyl group with 1-10 carbon atoms, straight-chain or branched alkenyl group or aralkyl group with 2-10 carbon atoms .

(20)按照上述(17)至(19)中任何一个的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3为氢原子，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团；且R4和R5互为不相同或相同的基团，每个基团选自氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(20) 7-aminoquinolinone derivatives and physiologically acceptable salts according to any one of the above (17) to (19), wherein R 2 and R 3 are hydrogen atoms with 1-10 carbons A straight-chain or branched chain alkyl group or a straight-chain or branched alkenyl group with 2-10 carbon atoms; and R 4 and R 5 are mutually different or identical groups, each Each group is selected from a hydrogen atom, an acyl group, a straight-chain or branched alkyl group with 1-10 carbon atoms, a straight-chain or branched alkenyl group with 2-10 carbon atoms or aralkyl groups.

(21)按照上述(20)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3是氢原子。(21) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (20) above, wherein R 2 and R 3 are hydrogen atoms.

(22)按照上述(20)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3是具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(22) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (20), wherein, R 2 and R 3 are linear or branched chain alkane with 1-10 carbon atoms A radical group or a linear or branched alkenyl group having 2-10 carbon atoms.

(23)按照上述(21)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R4为氢原子，且R5为氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(23) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (21), R 4 is a hydrogen atom, and R 5 is a hydrogen atom, an acyl group, with 1-10 A straight-chain or branched alkyl group with 2-10 carbon atoms, a straight-chain or branched alkenyl group or an aralkyl group with 2-10 carbon atoms.

(24)按照上述(22)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R4为氢原子，且R5为氢原子，酰基基团，具1-10个碳原子的直链或支链的烷基基团，具2-10个碳原子的直链或支链的链烯基基团或芳烷基团。(24) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (22), R 4 is a hydrogen atom, and R 5 is a hydrogen atom, an acyl group, with 1-10 A straight-chain or branched alkyl group with 2-10 carbon atoms, a straight-chain or branched alkenyl group or an aralkyl group with 2-10 carbon atoms.

(25)按照上述(23)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为酰基基团。(25) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (23) above, wherein R 5 is an acyl group.

(26)按照上述(24)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为酰基基团。(26) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (24) above, wherein R 5 is an acyl group.

(27)按照上述(25)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为由肉桂基(其上可有取代基)组成的酰基基团。(27) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (25) above, wherein R 5 is an acyl group consisting of a cinnamyl group (which may have a substituent).

(28)按照上述(26)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为由肉桂基(其上可有取代基)组成的酰基基团。(28) The 7-aminoquinolinone derivative and physiologically acceptable salts according to (26) above, wherein R 5 is an acyl group consisting of a cinnamyl group (which may have a substituent).

(29)按照上述(27)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为4-羟基-3-甲氧基肉桂基基团或3，5-二甲氧基-4-羟基肉桂基基团。(29) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (27), R 5 is a 4-hydroxyl-3-methoxycinnamyl group or a 3,5- Dimethoxy-4-hydroxycinnamyl group.

(30)按照上述(28)中的7-氨基喹啉酮衍生物以及生理学上可接受的盐类，其中，R5为4-羟基-3-甲氧基肉桂基基团或3，5-二甲氧基-4-羟基肉桂基基团。(30) According to the 7-aminoquinolinone derivatives and physiologically acceptable salts in the above (28), R is 4 -hydroxyl-3-methoxycinnamyl group or 3,5- Dimethoxy-4-hydroxycinnamyl group.

(31)含有按照上述(17)至(30)中任何一个的7-氨基喹啉酮衍生物以及生理学上可接受的盐类作为活性成份的抗过敏剂。(31) An antiallergic agent comprising the 7-aminoquinolinone derivative according to any one of the above (17) to (30) and a physiologically acceptable salt as an active ingredient.

(32)7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其可用下式(II)表示：(32) 7-nitroquinolinone derivatives and physiologically acceptable salts, which can be represented by the following formula (II):

Figure C0010642600121
Figure C0010642600121

其中in

R1为氢原子或一个烷基基团；R 1 is a hydrogen atom or an alkyl group;

R2为氢原子，烷基基团或链烯基基团；且 R is a hydrogen atom, an alkyl group or an alkenyl group; and

R3为氢原子，烷基基团或链烯基基团；R 3 is a hydrogen atom, an alkyl group or an alkenyl group;

(33)按照上述(32)中的7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其中，R1为氢原子或具1-10个碳原子的直链或支链的烷基基团。(33) According to the 7-nitroquinolinone derivatives and physiologically acceptable salts in the above (32), wherein, R 1 is a hydrogen atom or a straight or branched chain having 1-10 carbon atoms Alkyl group.

(34)按照上述(32)中的7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2和R3互为不同或相同，分别为氢原子，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(34) According to the 7-nitroquinolinone derivatives and physiologically acceptable salts in the above (32), wherein, R 2 and R 3 are different or the same, are hydrogen atoms respectively, and have 1-10 A straight-chain or branched chain alkyl group with 2-10 carbon atoms or a straight-chain or branched alkenyl group with 2-10 carbon atoms.

(35)按照上述(32)至(34)中任何一个的7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其中，R1为氢原子或具1-10个碳原子的直链或支链的烷基基团；R2和R3互为不同或相同，分别为氢原子，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(35) 7-nitroquinolinone derivatives and physiologically acceptable salts according to any one of the above-mentioned (32) to (34), wherein R 1 is a hydrogen atom or a compound having 1 to 10 carbon atoms Straight chain or branched chain alkyl group; R 2 and R 3 are different or the same, are hydrogen atoms, straight chain or branched chain alkyl groups with 1-10 carbon atoms or 2-10 carbon atoms straight-chain or branched-chain alkenyl groups of carbon atoms.

(36)按照上述(35)中的7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是具1-10个碳原子的烷基基团或具2-10个碳原子的直链或支链的链烯基基团，R3为氢原子。(36) According to the 7-nitroquinolinone derivatives and physiologically acceptable salts in the above (35), R 2 is an alkyl group with 1-10 carbon atoms or an alkyl group with 2-10 A straight-chain or branched alkenyl group of carbon atoms, R 3 is a hydrogen atom.

(37)按照上述(35)中的7-硝基喹啉酮衍生物以及生理学上可接受的盐类，其中，R2是酰基基团，R3是氢原子，具1-10个碳原子的直链或支链的烷基基团或具2-10个碳原子的直链或支链的链烯基基团。(37) According to the 7-nitroquinolinone derivatives and physiologically acceptable salts in the above (35), wherein, R 2 is an acyl group, R 3 is a hydrogen atom, with 1-10 carbon atoms straight-chain or branched-chain alkyl groups or straight-chain or branched-chain alkenyl groups having 2-10 carbon atoms.

(38)将说明(1)-(15)和(17)-(30)之一定义的7-氨基喹啉酮衍生物或其药用盐用于制备抗过敏药。(38) The use of the 7-aminoquinolinone derivative defined in any one of (1)-(15) and (17)-(30) or a pharmaceutically acceptable salt thereof for the preparation of an antiallergic drug will be explained.

(39)将说明(1)-(15)和(17)-(30)之一定义的7-氨基喹啉酮衍生物或其药用盐作为活性成份用于过敏性疾病。(39) The 7-aminoquinolinone derivative defined in any one of (1)-(15) and (17)-(30) or a pharmaceutically acceptable salt thereof is used as an active ingredient for allergic diseases.

(40)将说明(16)和(31)之一定义的抗过敏药用于过敏性疾病。(40) Use the antiallergic drug defined in either of (16) and (31) for allergic diseases.

(41)将说明(32)-(37)之一定义的7-硝基喹啉酮衍生物用于制备说明(1)-(15)和(17)-(30)之一定义的7-氨基喹啉酮衍生物或其药用盐，或用于制备说明(16)和(31)之一定义的抗过敏药。(41) The 7-nitroquinolinone derivative defined in one of (32)-(37) will be used to prepare the 7-nitroquinone defined in one of (1)-(15) and (17)-(30) An aminoquinolinone derivative or a pharmaceutically acceptable salt thereof, or an antiallergic drug as defined in one of (16) and (31) for the preparation.

因此，本发明提供了新颖的硝基喹啉酮衍生物，从这些硝基喹啉酮衍生物合成出来的氨基喹啉酮衍生物，以及相对安全的以该氨基喹啉酮衍生物为活性成份的抗过敏剂，该抗过敏剂可有效地对抗即发型和延迟型过敏。Therefore, the present invention provides novel nitroquinolinone derivatives, aminoquinolinone derivatives synthesized from these nitroquinolinone derivatives, and relatively safe aminoquinolinone derivatives with the aminoquinolinone derivatives as active ingredients An antiallergic agent that is effective against immediate and delayed allergies.

在本发明的通式(I)和(II)所代表的7-氨基喹啉酮衍生物和7-硝基喹啉酮衍生物中，R1表示氢原子或为烷基基团，该基团可是直链烷基基团或是支链的烷基基团。In the 7-aminoquinolinone derivatives and 7-nitroquinolinone derivatives represented by the general formula (I) and (II) of the present invention, R 1 represents a hydrogen atom or an alkyl group, and the group The group can be a straight chain alkyl group or a branched chain alkyl group.

该烷基的实例为：甲基基团，乙基基团，丙基基团，异丙基基团，正丁基基团，仲丁基基团，正戊基基团，己基基团，辛基基团和癸基基团。该烷基最好是有1-10个碳原子，更可取的是有1-8个碳原子。Examples of such alkyl groups are: methyl groups, ethyl groups, propyl groups, isopropyl groups, n-butyl groups, sec-butyl groups, n-pentyl groups, hexyl groups, octyl group and decyl group. The alkyl group preferably has 1-10 carbon atoms, more preferably 1-8 carbon atoms.

此外，通式(I)中的R2和R3表示氢原子，酰基基团，烷基基团和链烯基基团。酰基基团的实例是苯甲酰基基团和烷基酰基基团，后者的实例有甲酰基，乙酰基，丙酰基和丁酰基。苯甲酰基可以有取代基，且实例有对羟基苯甲酰基基团，对甲氧基苯甲酰基基团，2，4-二羟基苯甲酰基基团和2，4-二甲氧基苯甲酰基基团。较可取的是烷基酰基基团，更可取的是乙酰基团。In addition, R2 and R3 in the general formula (I) represent a hydrogen atom, an acyl group, an alkyl group and an alkenyl group. Examples of acyl groups are benzoyl groups and alkylacyl groups, examples of the latter being formyl, acetyl, propionyl and butyryl. The benzoyl group may have substituents and examples are p-hydroxybenzoyl group, p-methoxybenzoyl group, 2,4-dihydroxybenzoyl group and 2,4-dimethoxybenzoyl group formyl group. More preferred are alkylacyl groups, more preferred are acetyl groups.

作为烷基，它们既可是直链的烷基基团又可是支链的烷基基团。该实例包括：甲基基团，乙基基团，丙基基团，异丙基基团，正丁基基团，仲丁基基团，正戊基基团，己基基团，辛基基团和癸基基团。该烷基最好是有1-10个碳原子，更可取的是有1-8个碳原子。As alkyl groups, they can be both straight-chain and branched-chain alkyl groups. The examples include: methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, sec-butyl group, n-pentyl group, hexyl group, octyl group group and decyl group. The alkyl group preferably has 1-10 carbon atoms, more preferably 1-8 carbon atoms.

作为链烯基团，它们既可是直链的链烯基基团又可是支链的的链烯基基团。该实例包括：乙烯基基团，丙烯基基团，己烯基基团，辛烯基基团和香叶基基团。该链烯基最好是有2-10个碳原子，更可取的是有3-8个碳原子。As alkenyl radicals, they are both straight-chain alkenyl radicals and branched alkenyl radicals. Examples include: vinyl groups, propenyl groups, hexenyl groups, octenyl groups and geranyl groups. The alkenyl group preferably has 2-10 carbon atoms, more preferably 3-8 carbon atoms.

此外，通式(I)和(II)中的R4和R5既可相同又可不同，它们表示氢原子，酰基基团，烷基基团，链烯基基团和芳烷基基团。酰基基团的实例是烷基酰基基团，实例有甲酰基，乙酰基，丙酰基和丁酰基；苯甲酰基基团；取代的苯甲酰基基团以及肉桂酰基基团(可以是被取代的)。In addition, R 4 and R 5 in the general formulas (I) and (II) may be the same or different, and they represent a hydrogen atom, an acyl group, an alkyl group, an alkenyl group and an aralkyl group . Examples of acyl groups are alkylacyl groups such as formyl, acetyl, propionyl and butyryl; benzoyl groups; substituted benzoyl groups and cinnamoyl groups (which may be substituted ).

取代的苯甲酰基基团的实例包括：对羟基苯甲酰基基团，对甲氧基苯甲酰基基团，2，4-二羟基苯甲酰基基团和2，4-二甲氧基苯甲酰基基团。肉桂酰基基团(可以是被取代的)的实例包括：2-羟基肉桂酰基基团，3-羟基肉桂酰基基团，4-羟基肉桂酰基基团，3，4二羟基肉桂酰基基团，4-羟基-3-甲氧基肉桂酰基基团，3-羟基-4-甲氧基肉桂酰基基团，和3，5-二甲氧基-4-羟基肉桂酰基基团。较可取的是有取代的肉桂酰基基团。Examples of substituted benzoyl groups include: p-hydroxybenzoyl group, p-methoxybenzoyl group, 2,4-dihydroxybenzoyl group and 2,4-dimethoxybenzoyl group formyl group. Examples of cinnamoyl groups (which may be substituted) include: 2-hydroxycinnamoyl groups, 3-hydroxycinnamoyl groups, 4-hydroxycinnamoyl groups, 3,4 dihydroxycinnamoyl groups, 4 - a hydroxy-3-methoxycinnamoyl group, a 3-hydroxy-4-methoxycinnamoyl group, and a 3,5-dimethoxy-4-hydroxycinnamoyl group. Preferred are substituted cinnamoyl groups.

如果通式(I)和(II)中的R4和R5是烷基基团，它们既可是直链的烷基基团又可是支链的的烷基基团。该实例包括：甲基基团，乙基基团，丙基基团，异丙基基团，正丁基基团，仲丁基基团，正戊基基团，己基基团，辛基基团和癸基基团。该烷基最好是有1-10个碳原子，更可取的是有1-8个碳原子。If R 4 and R 5 in the general formulas (I) and (II) are alkyl groups, they can be both straight-chain and branched-chain alkyl groups. The examples include: methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, sec-butyl group, n-pentyl group, hexyl group, octyl group group and decyl group. The alkyl group preferably has 1-10 carbon atoms, more preferably 1-8 carbon atoms.

作为链烯基团，它们既可是直链的链烯基基团又可是支链的链烯基基团。该实例包括：乙烯基基团，丙烯基基团，己烯基基团，辛烯基基团和香叶基基团。该链烯基最好是有2-10个碳原子，更可取的是有3-8个碳原子。As alkenyl radicals, they are both straight-chain alkenyl radicals and branched alkenyl radicals. Examples include: vinyl groups, propenyl groups, hexenyl groups, octenyl groups and geranyl groups. The alkenyl group preferably has 2-10 carbon atoms, more preferably 3-8 carbon atoms.

芳烷基基团的实例是：苄基基团，取代的苄基基团(如，对甲氧基苄基基团和对羟基苄基基团)。本发明包括7-氨基喹啉酮衍生物，其中在具通式(I)和(II)的7-氨基喹啉酮衍生物上的R4和R5取代基是相同的基团，且7-氨基喹啉酮衍生物包括了上述所列出的不同的取代基团。Examples of aralkyl groups are: benzyl groups, substituted benzyl groups (eg, p-methoxybenzyl groups and p-hydroxybenzyl groups). The present invention includes 7 - aminoquinolinone derivatives, wherein R on the 7-aminoquinolinone derivatives with general formula (I) and (II) and R Substituents are the same group, and 7 - The aminoquinolinone derivatives include the various substituents listed above.

在本发明的通式(II)所代表的7-硝基喹啉酮衍生物中，该衍生物是本发明的7-氨基喹啉酮衍生物的重要的原料，R2表示氢原子，酰基基团，烷基基团和链烯基基团。酰基基团的实例是苯甲酰基基团和烷基酰基基团，后者的实例有甲酰基，乙酰基，丙酰基和丁酰基。苯甲酰基可以有取代基，且实例有对羟基苯甲酰基基团，对甲氧基苯甲酰基基团，2，4-二羟基苯甲酰基基团和2，4-二甲氧基苯甲酰基基团。较可取的是烷基酰基基团，更可取的是乙酰基团。In the 7-nitroquinolinone derivative represented by the general formula (II) of the present invention, the derivative is an important raw material of the 7-aminoquinolinone derivative of the present invention, R 2 represents a hydrogen atom, and the acyl group groups, alkyl groups and alkenyl groups. Examples of acyl groups are benzoyl groups and alkylacyl groups, examples of the latter being formyl, acetyl, propionyl and butyryl. The benzoyl group may have substituents and examples are p-hydroxybenzoyl group, p-methoxybenzoyl group, 2,4-dihydroxybenzoyl group and 2,4-dimethoxybenzoyl group formyl group. More preferred are alkylacyl groups, more preferred are acetyl groups.

作为烷基，它们既可是直链的烷基基团又可是支链的烷基基团。该实例包括：甲基基团，乙基基团，丙基基团，异丙基基团，正丁基基团，仲丁基基团，正戊基基团，己基基团，辛基基团和癸基基团。该烷基最好是有1-10个碳原子，更可取的是有1-8个碳原子。As alkyl groups, they can be both straight-chain and branched-chain alkyl groups. The examples include: methyl group, ethyl group, propyl group, isopropyl group, n-butyl group, sec-butyl group, n-pentyl group, hexyl group, octyl group group and decyl group. The alkyl group preferably has 1-10 carbon atoms, more preferably 1-8 carbon atoms.

作为链烯基团，它们既可是直链的链烯基基团又可是支链的链烯基基团。该实例包括：乙烯基基团，丙烯基基团，己烯基基团，辛烯基基团和香叶基基团。该链烯基最好是有2-10个碳原子，更可取的是有3-8个碳原子。As alkenyl radicals, they are both straight-chain alkenyl radicals and branched alkenyl radicals. Examples include: vinyl groups, propenyl groups, hexenyl groups, octenyl groups and geranyl groups. The alkenyl group preferably has 2-10 carbon atoms, more preferably 3-8 carbon atoms.

在通式(II)中，R3表示氢原子，烷基基团和链烯基基团，烷基的实例包括：甲基基团，乙基基团，丙基基团，异丙基基团，正丁基基团，仲丁基基团，正戊基基团，己基基团，辛基基团和癸基基团。该烷基最好是有1-10个碳原子，更可取的是有1-8个碳原子。In the general formula (II), R represents a hydrogen atom, an alkyl group and an alkenyl group, examples of the alkyl group include: a methyl group, an ethyl group, a propyl group, an isopropyl group group, n-butyl group, sec-butyl group, n-pentyl group, hexyl group, octyl group and decyl group. The alkyl group preferably has 1-10 carbon atoms, more preferably 1-8 carbon atoms.

作为链烯基团，它们既可是直链的的链烯基基团又可是支链的的链烯基基团。该实例包括：乙烯基基团，丙烯基基团，己烯基基团，辛烯基基团和香叶基基团。该链烯基最好是有2-10个碳原子，更可取的是有3-8个碳原子。As alkenyl radicals, they are both straight-chain alkenyl radicals and branched alkenyl radicals. Examples include: vinyl groups, propenyl groups, hexenyl groups, octenyl groups and geranyl groups. The alkenyl group preferably has 2-10 carbon atoms, more preferably 3-8 carbon atoms.

下列化合物是本发明中通式(I)所代表的7-氨基喹啉酮衍生物的实例。The following compounds are examples of 7-aminoquinolinone derivatives represented by the general formula (I) in the present invention.

7-氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-acetoxy-4-butoxy-2(1H)-quinolinone, 7-amino-3-acetoxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy) -2(1H)-quinolinone, 7-amino-3-acetoxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-acetoxy-4-hydroxyl- 2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-formyloxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-2(1H)-quinoline Ketone, 7-amino-3-formyloxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-formyloxy-4-(3-methyl-2-butan Alkenyloxy)-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-formyloxy Base-4-hydroxy-2(1H)-quinolinone,

7-氨基-4-乙酰氧基-3-甲氧基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-丁氧基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-己氧基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-香叶氧基-2(1H)-喹啉酮，7-amino-4-acetoxy-3-methoxy-2(1H)-quinolinone, 7-amino-4-acetoxy-3-butoxy-2(1H)-quinolinone, 7-amino-4-acetoxy-3-hexyloxy-2(1H)-quinolinone, 7-amino-4-acetoxy-3-(3-methyl-2-butenyloxy) -2(1H)-quinolinone, 7-amino-4-acetoxy-3-geranyloxy-2(1H)-quinolinone,

7-氨基-4-苯甲酰氧基-3-甲氧基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-丁氧基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-己氧基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-香叶氧基-2(1H)-喹啉酮，7-amino-4-benzoyloxy-3-methoxy-2(1H)-quinolinone, 7-amino-4-benzoyloxy-3-butoxy-2(1H)- Quinolinone, 7-amino-4-benzoyloxy-3-hexyloxy-2(1H)-quinolinone, 7-amino-4-benzoyloxy-3-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-amino-4-benzoyloxy-3-geranyloxy-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-2(1H)-quinolinone, 7-amino -3-methoxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-methoxy-4-(3-methyl-2-butenyloxy)-2( 1H)-quinolinone, 7-amino-3-methoxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-methoxy-4-hydroxyl-2(1H )-quinolinone,

7-氨基-3-异丙氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-2(1H)-quinoline Ketone, 7-amino-3-isopropoxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-(3-methyl-2-butan Enyloxy)-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-isopropoxy Base-4-hydroxy-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-2(1H)-quinolinone, 7-amino -3-butoxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-butoxy-4-(3-methyl-2-butenyloxy)-2( 1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-butoxy-4-hydroxyl-2(1H )-quinolinone,

7-氨基-3-己氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-2(1H)-quinolinone, 7-amino-3,4-dihexyloxy-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-(3-methyl-2-butenyloxy)-2( 1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-hydroxyl-2(1H )-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-butane Oxygen-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-( 2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)- 4-geranyloxy-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hydroxy-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-octyloxy-4-(3-methyl-2-butenyloxy) -2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hydroxyl- 2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-butoxy-2 (1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy) -4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-geranyloxy-2(1H )-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxy-2(1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-2(1H)-喹啉酮，7-amino-3-geranyloxy-4-methoxy-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-2(1H)-quinoline Ketone, 7-amino-3-geranyloxy-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-(3-methyl-2-butanol Alkenyloxy)-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-2(1H)-quinolinone, 7-amino-3-geranyloxy-4- Hydroxy-2(1H)-quinolinone,

7-氨基-3，4-二羟基-2(1H)-喹啉酮，7-氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-2(1H)-喹啉酮，7-amino-3,4-dihydroxy-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-methoxy-2(1H)-quinolinone, 7-amino-3-hydroxyl -4-butoxy-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-hexyloxy-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-( 3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-2(1H)-quinolinone,

7-氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-乙氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-ethoxy-1-methyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-butoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-acetoxy- 4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-methyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-acetoxy -4-Hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-formyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-methanol Acyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy Base-1-methyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-4-乙酰氧基-3-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-4-乙酰氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-amino-4-acetoxy-3-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-4-acetoxy-3-butoxy-1-methyl -2(1H)-quinolinone, 7-amino-4-acetoxy-3-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-4-acetoxy- 3-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-4-acetoxy-3-geranyloxy-1-methanol Base-2(1H)-quinolinone,

7-氨基-4-苯甲酰氧基-3-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-4-苯甲酰氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-Amino-4-benzoyloxy-3-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-4-benzoyloxy-3-butoxy- 1-methyl-2(1H)-quinolinone, 7-amino-4-benzoyloxy-3-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino- 4-Benzoyloxy-3-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-4-benzoyloxy- 3-geranyloxy-1-methyl-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-1-methyl-2( 1H)-quinolinone, 7-amino-3-methoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-( 3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-geranyloxy-1-methyl-2 (1H)-quinolinone, 7-amino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-异丙氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-iso Propoxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-geranyloxy Base-1-methyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-1-methyl-2( 1H)-quinolinone, 7-amino-3-butoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-( 3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-1-methyl-2 (1H)-quinolinone, 7-amino-3-butoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-1-methyl -2(1H)-quinolinone, 7-amino-3,4-dihexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-( 3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-1-methyl-2 (1H)-quinolinone, 7-amino-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy )-4-butoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl-2 (1H)-Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)- Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2- Methylpentyloxy)-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-1-methyl -2(1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-octyloxy- 4-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-1-methyl Base-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4- Butoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-1-methyl-2(1H)-quinoline Ketone, 7-amino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino- 3-(2-propenyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxyl-1 -Methyl-2(1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-1-甲基-2(1 H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-geranyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-cinnamon Phyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-1- Methyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-氨基-3，4-二羟基-1-甲基-2(1H)-喹啉酮，7-amino-3-hydroxyl-4-methoxy-1-methyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-butoxyl-1-methyl-2(1H )-quinolinone, 7-amino-3-hydroxyl-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-(3-methyl- 2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-1-methyl-2(1H)-quinolinone , 7-amino-3,4-dihydroxy-1-methyl-2(1H)-quinolinone,

7-氨基-3-乙酰氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-乙氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-ethoxy-1-ethyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-butoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-acetoxy- 4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-ethyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-acetoxy -4-Hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-formyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-1- Ethyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-methanol Acyloxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy Base-1-ethyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-1-ethyl-2( 1H)-quinolinone, 7-amino-3-methoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-( 3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-geranyloxy-1-ethyl-2 (1H)-quinolinone, 7-amino-3-methoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-异丙氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1 H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-1- Ethyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-iso Propoxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1 H)-quinolinone, 7-amino-3-isopropoxy-4-geranyl Oxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-1-ethyl-2( 1H)-quinolinone, 7-amino-3-butoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-( 3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-1-ethyl-2 (1H)-quinolinone, 7-amino-3-butoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-1-ethyl -2(1H)-quinolinone, 7-amino-3,4-dihexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-( 3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-1-ethyl-2 (1H)-quinolinone, 7-amino-3-hexyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy )-4-butoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-1-ethyl-2 (1H)-Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)- Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2- Methylpentyloxy)-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-1-ethyl -2(1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-octyloxy- 4-(3-Methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-1-ethyl Base-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hydroxyl-1-ethyl-2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4- Butoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-1-ethyl-2(1H)-quinoline Ketone, 7-amino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino- 3-(2-propenyloxy)-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxyl-1 -Ethyl-2(1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-geranyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-1- Ethyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-cinnamon Phyloxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-1- Ethyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-氨基-3，4-二羟基-1-乙基-2(1H)-喹啉酮，7-amino-3-hydroxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-butoxy-1-ethyl-2(1H )-quinolinone, 7-amino-3-hydroxyl-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-(3-methyl- 2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-1-ethyl-2(1H)-quinolinone , 7-amino-3,4-dihydroxy-1-ethyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-丙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丙氧基-1-丙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-丙基-2(1H)-喹啉酮，7-氨基-3-羟基-4-癸氧基-1-丙基-2(1H)-喹啉酮，7-amino-3-hydroxy-4-methoxy-1-propyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-propoxy-1-propyl-2(1H )-quinolinone, 7-amino-3-hydroxy-4-butoxy-1-propyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-decyloxy-1- Propyl-2(1H)-quinolinone,

7-氨基-3-乙酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-乙氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-1-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-ethoxy-1-butyl -2(1H)-quinolinone, 7-amino-3-acetoxy-1-butoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-acetoxy- 4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-butyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-acetoxy -4-Hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-1丁基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-formyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-1- Butyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hexyloxy-1butyl-2(1H)-quinolinone, 7-amino-3-formyl Oxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy -1-butyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-1-butyl-2( 1H)-quinolinone, 7-amino-3-methoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-( 3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-geranyloxy-1-butyl-2 (1H)-quinolinone, 7-amino-3-methoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-异丙氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-1- Butyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-iso Propoxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-geranyloxy Base-1-butyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-1-butyl-2( 1H)-quinolinone, 7-amino-3-butoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-( 3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-1-butyl-2 (1H)-quinolinone, 7-amino-3-butoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-1-butyl -2(1H)-quinolinone, 7-amino-3,4-dihexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-( 3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-1-butyl-2 (1H)-quinolinone, 7-amino-3-hexyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy )-4-butoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-1-butyl-2 (1H)-Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)- Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2- Methylpentyloxy)-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-1-butyl -2(1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-octyloxy- 4-(3-Methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-1-butane Base-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4- Butoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-1-butyl-2(1H)-quinoline Ketone, 7-amino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino- 3-(2-propenyloxy)-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxyl-1 -Butyl-2(1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-Amino-3-geranyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-1- Butyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-cinnamon Phyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-1- Butyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-氨基-3，4-二羟基-1-丁基-2(1H)-喹啉酮，7-amino-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-butoxy-1-butyl-2(1H )-quinolinone, 7-amino-3-hydroxyl-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-(3-methyl- 2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-1-butyl-2(1H)-quinolinone , 7-amino-3,4-dihydroxy-1-butyl-2(1H)-quinolinone,

7-氨基-3-乙酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-乙氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-ethoxy-1-hexyl-2 (1H)-quinolinone, 7-amino-3-acetoxy-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-hexyl Oxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H) -Quinolinone, 7-amino-3-acetoxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-hydroxyl-1 -hexyl-2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-formyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-amino-3-formyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-formyloxy -4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy-1- Hexyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-1-hexyl-2(1H) -Quinolinone, 7-amino-3-methoxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3- Methoxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone ,

7-氨基-3-异丙氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-isopropoxy -4-(3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-geranyloxy-1- Hexyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-1-hexyl-2(1H) -Quinolinone, 7-amino-3-butoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-(3-methyl Base-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone Linone, 7-amino-3-butoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-1-hexyl-2 (1H)-quinolinone, 7-amino-3,4-dihexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-(3-methyl Base-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone Linone, 7-amino-3-hexyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy) -4-butoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-1-hexyl-2(1H) -quinolinone, 7-amino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy )-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-1-hexyl-2 (1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-( 3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-1-hexyl-2(1H )-quinolinone, 7-amino-3-octyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-butane Oxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7 -amino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2 -propenyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxyl-1-hexyl-2( 1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-amino-3-geranyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-geranyloxy -4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-1-hexyl-2( 1H)-quinolinone, 7-amino-3-geranyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-1-己基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-氨基-3，4-二羟基-1-己基-2(1H)-喹啉酮，7-amino-3-hydroxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-butoxy-1-hexyl-2(1H)- Quinolinone, 7-amino-3-hydroxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-(3-methyl-2-butan Enoxy)-1-hexyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-amino- 3,4-dihydroxy-1-hexyl-2(1H)-quinolinone,

7-氨基-3-乙酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-乙氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-乙酰氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-acetoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-ethoxy-1-octyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-butoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-acetoxy- 4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-octyl -2(1H)-quinolinone, 7-amino-3-acetoxy-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-acetoxy -4-Hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-甲酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲酰氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-Amino-3-formyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-methanol Acyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-geranyloxy Base-1-octyl-2(1H)-quinolinone, 7-amino-3-formyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3，4-二甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-甲氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3,4-dimethoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-butoxy-1-octyl-2( 1H)-quinolinone, 7-amino-3-methoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-( 3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-methoxy-4-geranyloxy-1-octyl-2 (1H)-quinolinone, 7-amino-3-methoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-异丙氧基-4-甲氧基-1-辛氧基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-异丙氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-isopropoxy-4-methoxy-1-octyloxy-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-butoxy-1 -Octyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3- Isopropoxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-geranyl Oxy-1-octyl-2(1H)-quinolinone, 7-amino-3-isopropoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-丁氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3，4-二丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-丁氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-butoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3,4-dibutoxy-1-octyl-2( 1H)-quinolinone, 7-amino-3-butoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-( 3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-butoxy-4-geranyloxy-1-octyl-2 (1H)-quinolinone, 7-amino-3-butoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-己氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3，4-二己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-己氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-hexyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-butoxy-1-octyl -2(1H)-quinolinone, 7-amino-3,4-dihexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-( 3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-hexyloxy-4-geranyloxy-1-octyl-2 (1H)-quinolinone, 7-amino-3-hexyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-(2-甲基戊氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-甲基戊氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-(2-methylpentyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy )-4-butoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2-methylpentyloxy)-4-hexyloxy-1-octyl-2 (1H)-Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)- Quinolinone, 7-amino-3-(2-methylpentyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2- Methylpentyloxy)-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-辛氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-辛氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-octyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-butoxy-1-octyl -2(1H)-quinolinone, 7-amino-3-octyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-octyloxy- 4-(3-Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-octyloxy-4-geranyloxy-1-octyl Base-2(1H)-quinolinone, 7-amino-3-octyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-(2-丙烯氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-(2-丙烯氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-(2-propenyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4- Butoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hexyloxy-1-octyl-2(1H)-quinoline Ketone, 7-amino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino- 3-(2-propenyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-(2-propenyloxy)-4-hydroxyl-1 -octyl-2(1H)-quinolinone,

7-氨基-3-香叶氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3，4-二香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-香叶氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-geranyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-cinnamon Phyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3,4-digeranyloxy-1- Octyl-2(1H)-quinolinone, 7-amino-3-geranyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-氨基-3-羟基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-羟基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-羟基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-氨基-3-羟基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-氨基-3，4-二羟基-1-辛基-2(1H)-喹啉酮，7-amino-3-hydroxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-butoxy-1-octyl-2(1H )-quinolinone, 7-amino-3-hydroxyl-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-amino-3-hydroxyl-4-(3-methyl- 2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-amino-3-hydroxy-4-geranyloxy-1-octyl-2(1H)-quinolinone , 7-amino-3,4-dihydroxy-1-octyl-2(1H)-quinolinone,

7-甲氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，7-甲氨基-3-乙酰氧基-4-丁氧基-2(1H)-喹啉酮，7-甲氨基-3-乙酰氧基-4-己氧基-2(1H)-喹啉酮，7-甲氧基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-甲氨基-3-乙酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-甲氨基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮，7-methylamino-3-acetoxy-4-methoxy-2(1H)-quinolinone, 7-methylamino-3-acetoxy-4-butoxy-2(1H)-quinoline Ketone, 7-methylamino-3-acetoxy-4-hexyloxy-2(1H)-quinolinone, 7-methoxy-3-acetoxy-4-(3-methyl-2- Butenyloxy)-2(1H)-quinolinone, 7-methylamino-3-acetoxy-4-geranyloxy-2(1H)-quinolinone, 7-methylamino-3-acetyl Oxy-4-hydroxy-2(1H)-quinolinone,

7-甲氨基-3-甲酰氧基-4-甲氧基-2(1H)-喹啉酮，7-甲氨基-3-甲酰氧基-4-丁氧基-2(1H)-喹啉酮，7-甲氨基-3-甲酰氧基-4-己氧基-2(1H)-喹啉酮，7-甲氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-甲氨基-3-甲酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-甲氨基-3-甲酰氧基-4-羟基-2(1H)-喹啉酮，7-methylamino-3-formyloxy-4-methoxy-2(1H)-quinolinone, 7-methylamino-3-formyloxy-4-butoxy-2(1H)- Quinolinone, 7-methylamino-3-formyloxy-4-hexyloxy-2(1H)-quinolinone, 7-methylamino-3-formyloxy-4-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-methylamino-3-formyloxy-4-geranyloxy-2(1H)-quinolinone, 7-methylamino -3-formyloxy-4-hydroxy-2(1H)-quinolinone,

7-甲氨基-3，4-二氧基-2(1H)-喹啉酮，7-甲氨基-3-甲氧基-4-丁氧基-2(1H)-喹啉酮，7-甲氨基-3-甲氧基-4-己氧基-2(1H)-喹啉酮，7-甲氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-甲氨基-3-甲氧基-4-香叶氧基-2(1H)-喹啉酮，7-甲氨基-3-甲氧基-4-羟基-2(1H)-喹啉酮，7-methylamino-3,4-dioxy-2(1H)-quinolinone, 7-methylamino-3-methoxy-4-butoxy-2(1H)-quinolinone, 7- Methylamino-3-methoxy-4-hexyloxy-2(1H)-quinolinone, 7-methylamino-3-methoxy-4-(3-methyl-2-butenyloxy) -2(1H)-quinolinone, 7-methylamino-3-methoxy-4-geranyloxy-2(1H)-quinolinone, 7-methylamino-3-methoxy-4- Hydroxy-2(1H)-quinolinone,

7-甲氨基-3-(2-丙烯氧基)-4-羟基-1-乙基-2(1H)-喹啉酮，7-methylamino-3-(2-propenyloxy)-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-甲氨基-3-异丙氧基-4-甲氧基-2(1H)-喹啉酮，7-甲氨基-3-异丙氧基-4-丁氧基-2(1H)-喹啉酮，7-甲氨基-3-异丙氧基-4-己氧基-2(1H)-喹啉酮，7-甲氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-甲氨基-3-异丙氧基-4-香叶氧基-2(1H)-喹啉酮，7-甲氨基-3-异丙氧基-4-羟基-2(1H)-喹啉酮，7-methylamino-3-isopropoxy-4-methoxy-2(1H)-quinolinone, 7-methylamino-3-isopropoxy-4-butoxy-2(1H)- Quinolinone, 7-methylamino-3-isopropoxy-4-hexyloxy-2(1H)-quinolinone, 7-methylamino-3-isopropoxy-4-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-methylamino-3-isopropoxy-4-geranyloxy-2(1H)-quinolinone, 7-methylamino -3-isopropoxy-4-hydroxy-2(1H)-quinolinone,

7-甲氨基-3-丁氧基-4-甲氧基-2(1H)-喹啉酮，7-甲氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-甲氨基-3-羟基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-甲氨基-3-羟基-4-辛氧基-1-甲基-2(1H)-喹啉酮，7-甲氨基-3-异戊二烯氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-甲氨基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-甲氨基-3-(2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-methylamino-3-butoxy-4-methoxy-2(1H)-quinolinone, 7-methylamino-3-acetoxy-4-methoxy-1-methyl-2( 1H)-quinolinone, 7-methylamino-3-hydroxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-methylamino-3-hydroxy-4-octyloxy -1-methyl-2(1H)-quinolinone, 7-methylamino-3-prenyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-methyl Amino-3-geranyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-methylamino-3-(2-propenyloxy)-4-hydroxy-1-methyl -2(1H)-quinolinone,

7-甲氨基-3-异戊二烯氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-甲氨基-4-异戊二烯氧基-3-羟基-1-丁基-2(1H)-喹啉酮，7-甲氨基-3-异戊二烯氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-甲氨基-4-异戊二烯氧基-3-羟基-1-丁基-2(1H)-喹啉酮，7-methylamino-3-prenyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone, 7-methylamino-4-prenyloxy-3-hydroxyl- 1-Butyl-2(1H)-quinolinone, 7-methylamino-3-prenyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone, 7-methylamino -4-Prenyloxy-3-hydroxy-1-butyl-2(1H)-quinolinone,

7-乙氨基-3，4-二丁氧基-2(1H)-喹啉酮，7-乙氨基-3-丁氧基-4-己氧基-2(1H)-喹啉酮，7-乙氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-乙氨基-3-丁氧基-4-香叶氧基-2(1H)-喹啉酮，7-乙氨基-3-丁氧基-4-羟基-2(1H)-喹啉酮，7-ethylamino-3,4-dibutoxy-2(1H)-quinolinone, 7-ethylamino-3-butoxy-4-hexyloxy-2(1H)-quinolinone, 7 -Ethylamino-3-butoxy-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-ethylamino-3-butoxy-4-geranyl Oxy-2(1H)-quinolinone, 7-ethylamino-3-butoxy-4-hydroxy-2(1H)-quinolinone,

7-乙氨基-3-己氧基-4-甲氧基-2(1H)-喹啉酮，7-乙氨基--3-己氧基-4-丁氧基-2(1H)-喹啉酮，7-乙氨基-3，4-二己氧基-2(1H)-喹啉酮，7-乙氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-乙氨基-3-己氧基-4-香叶氧基-2(1H)-喹啉酮，7-乙氨基-3-己氧基-4-羟基-2(1H)-喹啉酮，7-ethylamino-3-hexyloxy-4-methoxy-2(1H)-quinolinone, 7-ethylamino--3-hexyloxy-4-butoxy-2(1H)-quinolinone Linone, 7-ethylamino-3,4-dihexyloxy-2(1H)-quinolinone, 7-ethylamino-3-hexyloxy-4-(3-methyl-2-buteneoxy Base)-2(1H)-quinolinone, 7-ethylamino-3-hexyloxy-4-geranyloxy-2(1H)-quinolinone, 7-ethylamino-3-hexyloxy- 4-Hydroxy-2(1H)-quinolinone,

7-乙氨基-3-(2-甲基戊氧基)-4-甲氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-甲基戊氧基)-4-丁氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-甲基戊氧基)-4-己氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-乙氨基-3-(2-甲基戊氧基)-4-香叶氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-甲基戊氧基)-4-羟基-2(1H)-喹啉酮，7-ethylamino-3-(2-methylpentyloxy)-4-methoxy-2(1H)-quinolinone, 7-ethylamino-3-(2-methylpentyloxy)-4 -Butoxy-2(1H)-quinolinone, 7-ethylamino-3-(2-methylpentyloxy)-4-hexyloxy-2(1H)-quinolinone, 7-ethylamino -3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-ethylamino-3-(2-methyl Pentyloxy)-4-geranyloxy-2(1H)-quinolinone, 7-ethylamino-3-(2-methylpentyloxy)-4-hydroxy-2(1H)-quinolinone ,

7-乙氨基-3-辛氧基-4-甲氧基-2(1H)-喹啉酮，7-乙氨基-3-辛氧基-4-丁氧基-2(1H)-喹啉酮，7-乙氨基-3-辛氧基-4-己氧基-2(1H)-喹啉酮，7-乙氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-乙氨基-3-辛氧基-4-香叶氧基-2(1H)-喹啉酮，7-乙氨基-3-辛氧基-4-羟基-2(1H)-喹啉酮，7-Ethylamino-3-octyloxy-4-methoxy-2(1H)-quinolinone, 7-ethylamino-3-octyloxy-4-butoxy-2(1H)-quinoline Ketone, 7-ethylamino-3-octyloxy-4-hexyloxy-2(1H)-quinolinone, 7-ethylamino-3-octyloxy-4-(3-methyl-2-butan Alkenyloxy)-2(1H)-quinolinone, 7-ethylamino-3-octyloxy-4-geranyloxy-2(1H)-quinolinone, 7-ethylamino-3-octyloxy Base-4-hydroxy-2(1H)-quinolinone,

7-乙氨基-3-(2-丙烯氧基)-4-甲氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-丙烯氧基)-4-丁氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-丙烯氧基)-4-己氧基-2(1H)-喹啉酮，7-ethylamino-3-(2-propenyloxy)-4-methoxy-2(1H)-quinolinone, 7-ethylamino-3-(2-propenyloxy)-4-butoxy -2(1H)-quinolinone, 7-ethylamino-3-(2-propenyloxy)-4-hexyloxy-2(1H)-quinolinone,

7-二甲氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-二甲氨基-3-(2-丙烯氧基)-4-香叶氧基-2(1H)-喹啉酮，7-乙氨基-3-(2-丙烯氧基)-4-羟基-2(1H)-喹啉酮，7-dimethylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-dimethylamino-3-( 2-propenyloxy)-4-geranyloxy-2(1H)-quinolinone, 7-ethylamino-3-(2-propenyloxy)-4-hydroxy-2(1H)-quinolinone ,

7-二甲氨基-3-香叶氧基-4-甲氧基-2(1H)-喹啉酮，7-二甲氨基-3-香叶氧基-4-丁氧基-2(1H)-喹啉酮，7-二甲氨基-3-香叶氧基-4-己氧基-2(1H)-喹啉酮，7-二甲氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-二甲氨基-3，4-二香叶氧基-2(1H)-喹啉酮，7-二甲氨基-3-香叶氧基-4-羟基-2(1H)-喹啉酮，7-Dimethylamino-3-geranyloxy-4-methoxy-2(1H)-quinolinone, 7-dimethylamino-3-geranyloxy-4-butoxy-2(1H )-quinolinone, 7-dimethylamino-3-geranyloxy-4-hexyloxy-2(1H)-quinolinone, 7-dimethylamino-3-geranyloxy-4-( 3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-dimethylamino-3,4-digeranyloxy-2(1H)-quinolinone, 7-di Methylamino-3-geranyloxy-4-hydroxy-2(1H)-quinolinone,

7-二甲氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-丁氧基-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-己氧基-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-香叶氧基-2(1H)-喹啉酮，7-二甲氨基-3，4-二羟基-2(1H)-喹啉酮，7-Dimethylamino-3-hydroxy-4-methoxy-2(1H)-quinolinone, 7-dimethylamino-3-hydroxyl-4-butoxy-2(1H)-quinolinone, 7-Dimethylamino-3-hydroxy-4-hexyloxy-2(1H)-quinolinone, 7-dimethylamino-3-hydroxy-4-(3-methyl-2-butenyloxy) -2(1H)-quinolinone, 7-dimethylamino-3-hydroxy-4-geranyloxy-2(1H)-quinolinone, 7-dimethylamino-3,4-dihydroxy-2 (1H)-quinolinone,

7-二甲氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-乙酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-乙酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-乙酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Dimethylamino-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-acetoxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-acetoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-dimethyl Amino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-acetoxy- 4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-acetoxy-4-hydroxy-1-methyl-2(1H)-quinolinone ,

7-二甲氨基-3-甲酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-甲酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-甲酰氧基-4-己氧基-1-甲基-2(1 H)-喹啉酮，7-二甲氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-甲酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-甲酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Dimethylamino-3-formyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-formyloxy-4-butoxy Base-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-formyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-Dimethylamino-3-formyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3 -Formyloxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-formyloxy-4-hydroxy-1-methyl-2 (1H)-quinolinone,

7-二甲氨基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-甲氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-Dimethylamino-3,4-dimethoxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-hexyloxy-4-hydroxyl-1-methyl- 2(1H)-quinolinone, 7-dimethylamino-3-methoxy-4-butoxy-1-methyl-2(1H)-quinolinone, 7-dimethylamino-3-hydroxy -4-hexyloxy-1-methyl-2(1H)-quinolinone,

7-二甲氨基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-二甲氨基-3-己氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-二甲氨基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-Dimethylamino-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-dimethylamino-3-hexyloxy-4-hydroxy-1-butyl -2(1H)-quinolinone, 7-dimethylamino-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone,

7-丁氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，7-丁氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮，7-丁氨基-3-甲氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，7-丁氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮，7-丁氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-甲氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-4-羟基-3-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-4-己氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-butylamino-3-acetoxy-4-methoxy-2(1H)-quinolinone, 7-butylamino-3-hydroxy-4-methoxy-2(1H)-quinolinone, 7-butylamino-3-methoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-acetoxy-4-methoxy-2( 1H)-quinolinone, 7-butylamino-3-hydroxy-4-methoxy-2(1H)-quinolinone, 7-butylamino-3-methoxy-4-(3-methyl- 2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-butylamino-3-methoxy-4-geranyloxy-1-methyl-2(1H)- Quinolinone, 7-butylamino-4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-4-hexyloxy-3-hydroxy-1- Methyl-2(1H)-quinolinone,

7-丁氨基-3-异丙氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氧基-3-异丙氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-1-己氧基-3-异丙氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-异丙氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-丁氧基-3-异丙氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Butylamino-3-isopropoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-butoxy-3-isopropoxy-4-butoxy -1-methyl-2(1H)-quinolinone, 7-butylamino-1-hexyloxy-3-isopropoxy-1-methyl-2(1H)-quinolinone, 7-butane Amino-3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-butylamino-3-isopropoxy -4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-butoxy-3-isopropoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone Linone,

7-丁氨基-3-丁氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3，4-二丁氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-丁氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-丁氧基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Butylamino-3-butoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3,4-dibutoxy-1-methyl- 2(1H)-quinolinone, 7-butylamino-3-butoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-butoxy -4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-butylamino-3-butoxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-butoxy-3-butoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-丁氨基-3-己氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-己氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3，4-二己氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-己氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Butylamino-3-hexyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-hexyloxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-butylamino-3,4-dihexyloxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-hexyloxy -4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-butylamino-3-hexyloxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-butylamino-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-丁氨基-3-(2-甲基戊氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-(2-甲基戊氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-Butylamino-3-(2-methylpentyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-(2-methylpentyl Oxy)-4-butoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl Base-2(1H)-quinolinone, 7-butylamino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2 (1H)-quinolinone, 7-butylamino-3-(2-methylpentyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone,

7-己氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-(2-丙烯氧基)-4-羟基-3-辛基-1-甲基-2(1H)-喹啉酮，7-异戊二烯氨基-4-羟基-3-辛氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-羟基-3-甲氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-羟基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-hexylamino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-(2-propenyloxy)-4-hydroxy-3-octyl-1- Methyl-2(1H)-quinolinone, 7-prenylamino-4-hydroxy-3-octyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino-4 -Hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone, 7-octylamino-3-hydroxy-4-methoxy-1-methyl-2(1H)-quinoline ketone,

7-辛氨基-4-甲氧基-3-辛氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-丁氧基-3-辛氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-己氧基-3-辛氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-辛氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-octylamino-4-methoxy-3-octyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino-4-butoxy-3-octyloxy-1- Methyl-2(1H)-quinolinone, 7-octylamino-4-hexyloxy-3-octyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino-3- Octyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-3-octyloxy-4-geranyloxy Base-1-methyl-2(1H)-quinolinone, 7-octylamino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-辛氨基-4-甲氧基-3-(2-丙烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-丁氧基-3-(2-丙烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-己氧基-3-(2-丙烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-(2-丙烯氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-(2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-octylamino-4-methoxy-3-(2-propenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-4-butoxy-3-(2 -propenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-4-hexyloxy-3-(2-propenyloxy)-1-methyl-2(1H) -Quinolinone, 7-octylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-3-(2-propenyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino-3-(2-propenyloxy) -4-Hydroxy-1-methyl-2(1H)-quinolinone,

7-辛氨基-4-甲氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-丁氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-己氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-octylamino-4-methoxy-3-geranyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino-4-butoxy-3-geranyloxy- 1-methyl-2(1H)-quinolinone, 7-octylamino-4-hexyloxy-3-geranyloxy-1-methyl-2(1H)-quinolinone, 7-octylamino -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-3-geranyloxy- 4-Hydroxy-1-methyl-2(1H)-quinolinone,

7-辛氨基-4-甲氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-丁氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-辛氨基-4-己氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-辛氨基-3-羟基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-辛氨基-3，4-二羟基-1-甲基-2(1H)-喹啉酮，7-octylamino-4-methoxy-3-hydroxy-1-methyl-2(1H)-quinolinone, 7-octylamino-4-butoxy-3-hydroxy-1-methyl-2 (1H)-quinolinone, 7-octylamino-4-hexyloxy-3-hydroxyl-1-methyl-2(1H)-quinolinone, 7-octylamino-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-octylamino-3-hydroxyl-4-geranyloxy-1-methyl-2(1H )-quinolinone, 7-octylamino-3,4-dihydroxy-1-methyl-2(1H)-quinolinone,

7-辛氨基-3-乙酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-辛氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-octylamino-3-acetoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-octyloxy-4-hydroxyl- 1-Butyl-2(1H)-quinolinone,

7(2-丙烯氨基)-3-乙酰氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氧基)-3-乙酰氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-乙酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7(2-propenylamino)-3-acetoxy-4-butoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenyloxy)-3-acetoxy- 4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-acetoxy-4-(3-methyl-2-butenyloxy) -1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-acetoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone , 7-(2-propenylamino)-3-acetoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-(2-丙烯氧基)-3-甲酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲酰氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氧基)-3-甲酰氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-(2-propenyloxy)-3-formyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-formyl Oxy-4-butoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenyloxy)-3-formyloxy-4-hexyloxy-1-butyl -2(1H)-quinolinone, 7-(2-propenylamino)-3-formyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H )-quinolinone, 7-(2-propenylamino)-3-formyloxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino )-3-formyloxy-4-hydroxyl-1-butyl-2(1H)-quinolinone,

7-(2-丙烯氨基)-3，4-二甲氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-甲氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-(2-propenylamino)-3,4-dimethoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-methoxy-4-butane Oxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-methoxy-4-hexyloxy-1-butyl-2(1H)-quinoline Ketone, 7-(2-propenylamino)-3-methoxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-( 2-propenylamino)-3-methoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-methoxy-4- Hydroxy-1-butyl-2(1H)-quinolinone,

7-(2-丙烯氨基)-3-异丙氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-异丙氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-异丙氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-异丙氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-异丙氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-(2-propenylamino)-3-isopropoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-isopropoxy Base-4-butoxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-isopropoxy-4-hexyloxy-1-butyl-2 (1H)-Quinolinone, 7-(2-propenylamino)-3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)- Quinolinone, 7-(2-propenylamino)-3-isopropoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)- 3-isopropoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-(2-丙烯氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-(2-propenylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-(2-丙烯氨基)-3-丁氧基-4-甲氧基-1-丁基-2(1 H)-喹啉酮，7-(2-丙烯氨基)-3-丁氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-(2-丙烯氨基)-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-(2-propenylamino)-3-butoxy-4-methoxy-1-butyl-2(1 H)-quinolinone, 7-(2-propenylamino)-3-butoxy -4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-(2-propenylamino)-3-butoxy-4-(3-methyl-2-butenyloxy )-1-butyl-2(1H)-quinolinone,

7-香叶氨基-3-丁氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-丁氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-geranylamino-3-butoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-butoxy-4-hydroxyl-1 -Butyl-2(1H)-quinolinone,

7-香叶氨基-3-己氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-己氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3，4-二己氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-己氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-己氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-geranylamino-3-hexyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-hexyloxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-geranylamino-3,4-dihexyloxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3 -Hexyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-hexyloxy-4-incense Phyloxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-hexyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-香叶氨基-3-(2-甲基戊氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-甲基戊氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-甲基戊氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-甲基戊氧基)-4-羟基-1-丁基-2(1H)-喹啉酮，7-geranylamino-3-(2-methylpentyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-methyl Basepentyloxy)-4-butoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-methylpentyloxy)-4-hexyloxy- 1-Butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1- Butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-methylpentyloxy)-4-geranyloxy-1-butyl-2(1H)-quinolinone , 7-geranylamino-3-(2-methylpentyloxy)-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-香叶氨基-3-辛氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-辛氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-辛氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-辛氧基-4((3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-辛氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-辛氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-geranylamino-3-octyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-octyloxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-geranylamino-3-octyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-geranyl Amino-3-octyloxy-4((3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-octyloxy- 4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-octyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone ,

7-香叶氨基-3-(2-丙烯氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-丙烯氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-丙烯氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-香叶氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-geranylamino-3-(2-propenyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-propenyloxy )-4-butoxy-1-butyl-2(1H)-quinolinone, 7-geranylamino-3-(2-propenyloxy)-4-hexyloxy-1-butyl-2 (1H)-Quinolinone, 7-geranylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)- Quinolinone,

7-乙酰氨基-4-羟基-3-甲氧基-2(1H)-喹啉酮，7-乙酰氨基-3-己氧基-4-羟基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-乙酰氨基-4-己氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-乙酰氨基-4-辛氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-乙酰氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-乙酰氨基-4-香叶氧基-3-(2-丙烯氧基)-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-4-羟基-3-(2-丙烯氧基)-1-丁基-2(1H)-喹啉酮，7-Acetamido-4-hydroxyl-3-methoxy-2(1H)-quinolinone, 7-acetamido-3-hexyloxy-4-hydroxyl-2(1H)-quinolinone, 7- Acetylamino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-acetamido-4-hexyloxy-3-hydroxy-1-methyl-2(1H )-quinolinone, 7-acetamido-4-octyloxy-3-hydroxyl-1-methyl-2(1H)-quinolinone, 7-acetamido-3-octyloxy-4-hydroxyl- 1-methyl-2(1H)-quinolinone, 7-acetamido-4-geranyloxy-3-(2-propenyloxy)-1-butyl-2(1H)-quinolinone, 7-Acetamido-4-hydroxy-3-(2-propenyloxy)-1-butyl-2(1H)-quinolinone,

7-乙酰氨基-3-香叶氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-香叶氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-香叶氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3，4-二香叶氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-香叶氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-Acetamido-3-geranyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-acetylamino-3-geranyloxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-acetamido-3-geranyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-acetamido -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-acetamido-3,4-digeranyl Oxy-1-butyl-2(1H)-quinolinone, 7-acetamido-3-geranyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-乙酰氨基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-羟基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-羟基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-羟基-4-香叶氧基--1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3，4-二羟基-1-丁基-2(1H)-喹啉酮，7-Acetamido-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-acetamido-3-hydroxy-4-butoxy-1-butyl-2 (1H)-quinolinone, 7-acetamido-3-hydroxyl-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-acetamido-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-acetamido-3-hydroxyl-4-geranyloxy--1-butyl-2( 1H)-quinolinone, 7-acetamido-3,4-dihydroxy-1-butyl-2(1H)-quinolinone,

7-乙酰氨基-3-乙酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-乙酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-乙酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-乙酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-乙酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Acetamido-3-acetoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-acetoxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-acetamido-3-acetoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-acetoxy -4-(3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-acetoxy-4-geranyloxy-1- Hexyl-2(1H)-quinolinone, 7-acetamido-3-acetoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-乙酰氨基-3-甲酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Acetamido-3-formyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-acetylamino-3-formyloxy-4-butoxy-1 -Hexyl-2(1H)-quinolinone, 7-acetamido-3-formyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3- Formyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-formyloxy-4-geranyl Oxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-formyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-乙酰氨基-3，4-二甲氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-甲氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Acetamido-3,4-dimethoxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-methoxy-4-butoxy-1-hexyl-2( 1H)-quinolinone, 7-acetylamino-3-methoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-acetylamino-3-methoxy-4- (3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-methoxy-4-geranyloxy-1-hexyl-2 (1H)-quinolinone, 7-acetamido-3-methoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-乙酰氨基-3-异丙氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-异丙氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-异丙氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-异丙氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-异丙氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Acetamido-3-isopropoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-isopropoxy-4-butoxy-1 -Hexyl-2(1H)-quinolinone, 7-acetamido-3-isopropoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3- Isopropoxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-isopropoxy-4-geranyl Oxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3-isopropoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-乙酰氨基-3-丁氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3，4-二丁氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-丁氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-乙酰氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-Acetamido-3-butoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-acetamido-3,4-dibutoxy-1-hexyl-2( 1H)-quinolinone, 7-acetylamino-3-butoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-acetylamino-3-butoxy-4- (3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone,

7-乙酰氨基-3，4-二香叶氧基-1-丁基-2(1H)-喹啉酮，7-乙酰氨基-3-香叶氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-Acetamido-3,4-Digeranyloxy-1-butyl-2(1H)-quinolinone, 7-Acetylamino-3-geranyloxy-4-hydroxy-1-butyl- 2(1H)-quinolinone,

7-苯甲酰氨基-4-羟基-3-辛氧基-1-甲基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-甲氧基-1-丁基--2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-苯甲酰氨基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苯甲酰氨基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-苯甲酰氨基-3-己氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-苯甲酰氨基-3-己氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-苯甲酰氨基-3，4-二己氧基-1-乙基-2(1H)-喹啉酮，7-苯甲酰氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-苯甲酰氨基-3-己氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-苯甲酰氨基-3-己氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Benzamido-4-hydroxy-3-octyloxy-1-methyl-2(1H)-quinolinone, 7-benzamido-3-hydroxy-4-methoxy-1- Butyl--2(1H)-quinolinone, 7-benzamido-3-hydroxy-4-butoxy-1-butyl-2(1H)-quinolinone, 7-benzamido -3-hydroxy-4-butoxy-1-butyl-2(1H)-quinolinone, 7-benzamido-3-hydroxy-4-hexyloxy-1-butyl-2(1H )-quinolinone, 7-benzamido-3-butoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-benzamido-3-butane Oxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-benzamido-3-hexyloxy-4-methoxy-1-methyl-2(1H)- Quinolinone, 7-benzamido-3-hexyloxy-4-butoxy-1-methyl-2(1H)-quinolinone, 7-benzamido-3,4-dihexyl Oxy-1-ethyl-2(1H)-quinolinone, 7-benzamido-3-hexyloxy-4-(3-methyl-2-butenyloxy)-1-ethyl -2(1H)-quinolinone, 7-benzamido-3-hexyloxy-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-benzamido -3-hexyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-苯甲酰氨基-3-(2-甲基戊氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-甲基戊氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-甲基戊氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-甲基戊氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-benzamido-3-(2-methylpentyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-(2- Methylpentyloxy)-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-(2-methylpentyloxy)-4-hexyloxy -1-hexyl-2(1H)-quinolinone, 7-benzamido-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1 -Hexyl-2(1H)-quinolinone, 7-Benzamido-3-(2-methylpentyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone , 7-benzamido-3-(2-methylpentyloxy)-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-苯甲酰氨基-3-辛氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-辛氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-辛氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-辛氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-辛氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Benzamido-3-octyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-octyloxy-4-butoxy -1-hexyl-2(1H)-quinolinone, 7-benzamido-3-octyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-benzyl Amido-3-octyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-octyloxy -4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-octyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone ,

7-苯甲酰氨基-3-(2-丙烯氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-丙烯氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-丙烯氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-丙烯氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-(2-丙烯氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-Benzamido-3-(2-propenyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-(2-propenyloxy Base)-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-(2-propenyloxy)-4-hexyloxy-1-hexyl-2 (1H)-Quinolinone, 7-benzamido-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)- Quinolinone, 7-benzamido-3-(2-propenyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3- (2-propenyloxy)-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-苯甲酰氨基-3-香叶氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-香叶氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-香叶氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3，4-二香叶氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-香叶氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-Benzamido-3-geranyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-geranyloxy-4-butanol Oxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-geranyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7 -Benzamido-3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-benzamido-3 , 4-Digeranyloxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-geranyloxy-4-hydroxyl-1-hexyl-2(1H)-quinolinone Linone,

7-苯甲酰氨基-3-羟基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-己氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3-羟基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-苯甲酰氨基-3，4-二羟基-1-己基-2(1H)-喹啉酮，7-Benzamido-3-hydroxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-hydroxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-benzamido-3-hydroxyl-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-hydroxyl -4-(3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-benzamido-3-hydroxyl-4-geranyloxy-1- Hexyl-2(1H)-quinolinone, 7-benzamido-3,4-dihydroxy-1-hexyl-2(1H)-quinolinone,

7-苯甲酰氨基-3-乙酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苯甲酰氨基-3-乙酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苯甲酰氨基-3-乙酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Benzamido-3-acetoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzamido-3-acetoxy-4-butoxy Base-1-octyl-2(1H)-quinolinone, 7-benzamido-3-acetoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7 -Cinnamoylamino-3-butoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-butoxy-4-hydroxyl-1- Methyl-2(1H)-quinolinone,

7-肉桂酰氨基-3-己氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-丁氨基-3-己氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3，4-二己氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-己氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-乙酰氧基肉桂酰氨基)-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-乙酰氧基肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-羟氧基肉桂酰氨基)-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-羟基肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-cinnamoylamino-3-hexyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-butylamino-3-hexyloxy-4-butoxy-1 -Methyl-2(1H)-quinolinone, 7-cinnamoylamino-3,4-dihexyloxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3- Hexyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-hexyloxy-4-geranyl Oxy-1-methyl-2(1H)-quinolinone, 7-(3,5-dimethoxy-4-acetoxycinnamoylamino)-3-hexyloxy-4-hydroxyl-1 -Methyl-2(1H)-quinolinone, 7-(3,5-dimethoxy-4-acetoxycinnamoylamino)-3-octyloxy-4-hydroxyl-1-methyl- 2(1H)-quinolinone, 7-hydroxycinnamoylamino)-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone, 7-(3,5- Dimethoxy-4-hydroxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-肉桂酰氨基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-肉桂酰氨基)-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-(4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7 -(4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-butoxy-1-methyl-2(1H)-quinolinone, 7- (4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-( 4-Hydroxy-cinnamoylamino)-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-(4-hydroxy-cinnamoylamino)-3-(2-methylpentyloxy Base)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-cinnamylamino-3-(2-methylpentyloxy) -4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-(4-hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy) -4-Hydroxy-1-methyl-2(1H)-quinolinone,

7-(4-羟基-3-甲氧基肉桂酰氨基)-3-辛氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-(4-Hydroxy-3-methoxycinnamoylamino)-3-octyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3 -octyloxy-4-butoxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-octyloxy-4-hexyloxy-1-methyl-2( 1H)-quinolinone, 7-cinnamoylamino-3-octyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7 -Cinnamoylamino-3-octyloxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-(4-hydroxy-3-methoxycinnamoylamino)-3 -octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-肉桂酰氨基-3-(2-丙烯氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-cinnamoylamino-3-(2-propenyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-(2-propenyloxy )-4-butoxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-(2-propenyloxy)-4-hexyloxy-1-methyl-2 (1H)-Quinolinone, 7-cinnamoylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)- Quinolinone,

7-肉桂酰氨基-4-甲氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-4-丁氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-4-己氧基-3-香叶氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3，4-二香叶氧基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-cinnamoylamino-4-methoxy-3-geranyloxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-4-butoxy-3-geranyloxy Base-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-4-hexyloxy-3-geranyloxy-1-methyl-2(1H)-quinolinone, 7 -Cinnamoylamino-3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3, 4-Digeranyloxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-3-geranyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone Linone,

7-肉桂酰氨基-4-甲氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-4-丁氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-cinnamoylamino-4-methoxy-3-hydroxy-1-methyl-2(1H)-quinolinone, 7-cinnamoylamino-4-butoxy-3-hydroxy-1-methyl -2(1H)-quinolinone,

7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-(4-羟基肉桂酰氨基)-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-甲基-2(1 H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-(2-甲基戊氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-(4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7 -(4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-butoxy-1-methyl-2(1H)-quinolinone, 7- (4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-( 4-Hydroxy-3-methoxycinnamoylamino)-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-(4 -Hydroxycinnamoylamino)-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7 -Cinnamoylamino-3-(2-methylpentyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-(4-hydroxy-3-methoxy Cinnamoylamino)-3-(2-methylpentyloxy)-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-(4-羟基-3-甲氧基肉桂酰氨基)-3-辛氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-辛氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-(4-羟基-3-甲氧基肉桂酰氨基)-3-辛氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-(4-Hydroxy-3-methoxycinnamoylamino)-3-octyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3- Octyloxy-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-octyloxy-4-hexyloxy-1-hexyl-2(1H)- Quinolinone, 7-cinnamoylamino-3-octyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino -3-octyloxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-(4-hydroxy-3-methoxycinnamoylamino)-3-octyloxy- 4-Hydroxy-1-hexyl-2(1H)-quinolinone,

7-肉桂酰氨基-3-(2-丙烯氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-2己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-(2-丙烯氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-cinnamoylamino-3-(2-propenyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-(2-propenyloxy) -4-butoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-(2-propenyloxy)-4-hexyloxy-1-hexyl-2(1H) -Quinolinone, 7-cinnamylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-2-hexyl-2(1H)-quinolinone , 7-cinnamoylamino-3-(2-propenyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-(2-propenyloxy base)-4-hydroxyl-1-hexyl-2(1H)-quinolinone,

7-肉桂酰氨基-3-香叶氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-丁氧基-1-己基-2(1 H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3，4-二香叶氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-香叶氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-cinnamoylamino-3-geranyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-geranyloxy-4-butoxy -1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-geranyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-cinnamon Amino-3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-cinnamylamino-3,4-di Geranyloxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-geranyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-肉桂酰氨基-3-羟基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-羟基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-羟基肉桂酰氨基)-3-羟基-4-己氧基-1-己基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-羟基肉桂酰氨基)-3-羟基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3-羟基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-肉桂酰氨基-3，4-二羟基-1-己基-2(1H)-喹啉酮，7-cinnamoylamino-3-hydroxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3-hydroxy-4-butoxy-1-hexyl-2 (1H)-Quinolinone, 7-(3,5-dimethoxy-4-hydroxycinnamoylamino)-3-hydroxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone , 7-(3,5-dimethoxy-4-hydroxycinnamoylamino)-3-hydroxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)- Quinolinone, 7-cinnamoylamino-3-hydroxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-cinnamoylamino-3,4-dihydroxy-1-hexyl -2(1H)-quinolinone,

7-肉桂酰氨基-3-乙酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-(3，5-二甲氧基-4-羟基肉桂酰氨基)-3-乙酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-肉桂酰氨基-3-乙酰氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-乙酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-cinnamoylamino-3-acetoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-(3,5-dimethoxy-4-hydroxycinnamoylamino )-3-acetoxy-4-butoxy-1-octyl-2(1H)-quinolinone, 7-cinnamoylamino-3-acetoxy-4-hexyloxy-1-octyl -2(1H)-quinolinone, 7-benzylamino-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone , 7-benzylamino-3-acetoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-acetoxy-4-hydroxyl-1- Methyl-2(1H)-quinolinone,

7-苄氨基-3-甲酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Benzylamino-3-formyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-formyloxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-benzylamino-3-formyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino -3-Formyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-formyloxy- 4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-formyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone ,

7-苄氨基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-benzylamino-3,4-dimethoxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-methoxy-4-butoxy-1-methyl- 2(1H)-quinolinone, 7-benzylamino-3-methoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-methoxy -4-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-methoxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-benzylamino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-苄氨基-3-异丙氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-异丙氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-异丙氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-异丙氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-异丙氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Benzylamino-3-isopropoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-isopropoxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-benzylamino-3-isopropoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino -3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-isopropoxy- 4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-isopropoxy-4-hydroxy-1-methyl-2(1H)-quinolinone ,

7-苄氨基-3-丁氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3，4-二丁氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-丁氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-苄氨基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Benzylamino-3-butoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3,4-dibutoxy-1-methyl- 2(1H)-quinolinone, 7-benzylamino-3-butoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-butoxy -4-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-benzylamino-3-butoxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-benzylamino-3-butoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-苄氨基-3-己氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-己氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3，4-二己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-己氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-己氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-Benzylamino-3-hexyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hexyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-benzylamino-3,4-dihexyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hexyloxy -4-(3-Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hexyloxy-4-geranyloxy-1 -octyl-2(1H)-quinolinone, 7-benzylamino-3-hexyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-苄氨基-3-(2-甲基戊氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-甲基戊氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-甲基戊氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-甲基戊氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-甲基戊氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-benzylamino-3-(2-methylpentyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-(2-methylpentyl Oxy)-4-butoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-(2-methylpentyloxy)-4-hexyloxy-1-octyl Base-2(1H)-quinolinone, 7-benzylamino-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2 (1H)-quinolinone, 7-benzylamino-3-(2-methylpentyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino -3-(2-methylpentyloxy)-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-苄氨基-3-辛氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-辛氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-辛氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-辛氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-Benzylamino-3-octyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-octyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-benzylamino-3-octyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3- Octyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-octyloxy-4-geranyloxy Base-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-苄氨基-3-己氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-苄氨基-3-己氧基-4-羟基-1-丙基-2(1H)-喹啉酮，7-Benzylamino-3-hexyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone, 7-benzylamino-3-hexyloxy-4-hydroxy-1-propyl-2 (1H)-quinolinone,

7-苄氨基-3-(2-丙烯氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-丙烯氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-丙烯氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-丙烯氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-(2-丙烯氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-Benzylamino-3-(2-propenyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-(2-propenyloxy)- 4-butoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-(2-propenyloxy)-4-hexyloxy-1-octyl-2(1H) -Quinolinone, 7-benzylamino-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-Benzylamino-3-(2-propenyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-(2-propenyloxy) -4-Hydroxy-1-octyl-2(1H)-quinolinone,

7-苄氨基-3-香叶氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-香叶氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-香叶氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3，4-二香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-香叶氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-Benzylamino-3-geranyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-geranyloxy-4-butoxy- 1-octyl-2(1H)-quinolinone, 7-benzylamino-3-geranyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-benzylamino-3,4-digeranyl Oxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-geranyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-苄氨基-3-羟基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-羟基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-羟基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-苄氨基-3-羟基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-苄氨基-3，4-二羟基-1-辛基-2(1H)-喹啉酮。7-Benzylamino-3-hydroxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hydroxy-4-butoxy-1-octyl-2 (1H)-quinolinone, 7-benzylamino-3-hydroxyl-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-benzylamino-3-hydroxyl-4-geranyloxy-1-octyl-2(1H )-quinolinone, 7-benzylamino-3,4-dihydroxy-1-octyl-2(1H)-quinolinone.

这些化合物的生理学上可接受的盐类也包括在说明实例中。Physiologically acceptable salts of these compounds are also included in the illustrative examples.

就上述在3位和/或4位具有羟基的化合物而言，这里使用的术语“生理学上可接受的盐类”指的是上述化合物的非毒性的碱加成盐，其包括钠盐，钾盐，镁盐，钙盐，铵盐，非毒性胺盐等等。这些生理学上可接受的盐类可用已知的方法制备，它们也被包括在本发明中。就3位和/或4位上没有羟基的化合物而言，术语“生理学上可接受的盐类”是指非毒性的氨基基团加成盐以及无机的盐(例如盐酸和硫酸)，磷酸，有机酸盐(例如乙酸，丙酸，琥珀酸，酒石酸，马来酸和富马酸)以及磺酸盐(例如甲磺酸)等等。With regard to the above-mentioned compounds having a hydroxyl group at the 3-position and/or 4-position, the term "physiologically acceptable salts" as used herein refers to non-toxic base addition salts of the above-mentioned compounds, which include sodium salts, potassium salts, salt, magnesium salt, calcium salt, ammonium salt, non-toxic amine salt and more. These physiologically acceptable salts can be prepared by known methods and are also included in the present invention. For compounds without a hydroxyl group in the 3- and/or 4-position, the term "physiologically acceptable salts" refers to non-toxic amino group addition salts as well as inorganic salts (such as hydrochloric acid and sulfuric acid), phosphoric acid, Organic acid salts (such as acetic acid, propionic acid, succinic acid, tartaric acid, maleic acid and fumaric acid) and sulfonates (such as methanesulfonic acid) and the like.

这些生理学上可接受的盐类可用已知方法制备，它们也被包括在本发明中。These physiologically acceptable salts can be prepared by known methods and are also included in the present invention.

本发明中具式(II)的7-硝基喹啉酮衍生物是合成本发明7-氨基喹啉酮的重要中间体，下列化合物为说明实例。The 7-nitroquinolinone derivatives of formula (II) in the present invention are important intermediates for synthesizing the 7-aminoquinolinones of the present invention, and the following compounds are illustrative examples.

7-硝基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-2(1H)-quinoline Ketone, 7-nitro-3-acetoxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butan Alkenyloxy)-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-acetoxy Base-4-hydroxy-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy-2(1H)- Quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro -3-formyloxy-4-hydroxy-2(1H)-quinolinone,

7-硝基-3，4-二甲氧基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-2(1H)-quinolinone, 7 -Nitro-3-methoxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-methoxy-4-(3-methyl-2-butenyloxy )-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-methoxy-4 -Hydroxy-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy-2(1H)- Quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro -3-isopropoxy-4-hydroxy-2(1H)-quinolinone,

7-硝基-3-丁氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-2(1H)-喹啉酮，，7-硝基-3-丁氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-2(1H)-quinolinone, 7 -Nitro-3-butoxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-butoxy-4-(3-methyl-2-butenyloxy )-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-butoxy- 4-Hydroxy-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3，4-二己氧基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-2(1H)-quinoline Ketone, 7-nitro-3,4-dihexyloxy-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-(3-methyl-2-butenyloxy )-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4 -Hydroxy-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4 -Butoxy-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-2(1H)-quinolinone, 7-nitro -3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3-(2-methyl Pentyloxy)-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hydroxy-2(1H)-quinolinone ,

7-硝基-3-辛氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-2(1H)-quinoline Ketone, 7-nitro-3-octyloxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-(3-methyl-2-butan Alkenyloxy)-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyloxy-2(1H)-quinolinone, 7-nitro-3-octyloxy Base-4-hydroxy-2(1H)-quinolinone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-羟基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-butoxy -2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-(2- Propyloxy)-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-geranyloxy Base-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hydroxy-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3，4-二香叶氧基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-羟基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy-2(1H)- Quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-(3-methyl -2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3,4-digeranyloxy-2(1H)-quinolinone, 7-nitro-3-cinnamon Phyloxy-4-hydroxy-2(1H)-quinolinone,

7-硝基-3，4-二羟基-2(1H)-喹啉酮，7-硝基-3-羟基-4-甲氧基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-2(1H)-喹啉酮，7-nitro-3,4-dihydroxy-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-methoxy-2(1H)-quinolinone, 7-nitro- 3-Hydroxy-4-butoxy-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-hexyloxy-2(1H)-quinolinone, 7-nitro-3- Hydroxy-4-(3-methyl-2-butenyloxy)-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-geranyloxy-2(1H)-quinoline ketone,

7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-乙氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-ethoxy-1- Methyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3- Acetoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butenyloxy) -1-methyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro Base-3-acetoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro -3-Formyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-formyloxy- 4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone ,

7-硝基-3，4-二甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-4-己氧基-3-羟基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-1-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-1-methyl- 2(1H)-quinolinone, 7-nitro-4-hexyloxy-3-hydroxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4 -Hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-(3-methyl-1-methyl-2-butenyloxy) -1-methyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro Base-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-1-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro -3-isopropoxy-4-(3-methyl-1-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3- Isopropoxy-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hydroxy-1-methyl-2(1H )-quinolinone,

7-硝基-3-丁氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-methyl- 2(1H)-quinolinone, 7-nitro-3-butoxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-butoxy -4-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3，4-二己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-nitro-3,4-dihexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy -4-(3-Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-1 -Methyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyl Oxy)-4-butoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-1-methyl Base-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2 (1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro -3-(2-methylpentyloxy)-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-辛氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-1- Methyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3- Octyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyloxy Base-1-methyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-(-2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)- 4-butoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-1-methyl-2(1H) -quinolinone, 7-nitro-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-geranyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-(-2-propenyloxy )-4-hydroxyl-1-methyl-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy- 1-methyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy- 4-Hydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-羟基-4-甲氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-甲基-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-1-甲基-2(1H)-喹啉酮，7-硝基-3，4-二羟基-1-甲基-2(1H)-喹啉酮，7-nitro-3-hydroxy-4-methoxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-butoxy-1-methyl-2 (1H)-quinolinone, 7-nitro-3-hydroxyl-4-hexyloxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-methyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-geranyloxy-1-methyl-2(1H )-quinolinone, 7-nitro-3,4-dihydroxy-1-methyl-2(1H)-quinolinone,

7-硝基-3-乙酰氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-乙氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-ethoxy-1- Ethyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3- Acetoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butenyloxy) -1-ethyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro Base-3-acetoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy- 1-ethyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro -3-Formyloxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-formyloxy- 4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone ,

7-硝基-3，4-二甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-1-ethyl- 2(1H)-quinolinone, 7-nitro-3-methoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-methoxy -4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-1 -Ethyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy- 1-ethyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro -3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy- 4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone ,

7-硝基-3-丁氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-ethyl- 2(1H)-quinolinone, 7-nitro-3-butoxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-butoxy -4-(3-Methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-1 -Ethyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-1- Ethyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy -4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-1 -Ethyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyl Oxy)-4-butoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-1-ethyl Base-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-ethyl-2 (1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro -3-(2-methylpentyloxy)-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-辛氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-辛氧基，-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-4-(3-甲基-2-丁烯氧基)-3-辛氧基-1-乙基-2(1H)-喹啉酮，7-硝基-4-香叶氧基-3-辛氧基-1-乙基-2(1H)-喹啉酮，7-硝基-4-己氧基-3-辛氧基-1-乙基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-1- Ethyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3- Octyloxy, -4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyl Oxygen-1-ethyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7- Nitro-4-(3-methyl-2-butenyloxy)-3-octyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-4-geranyloxy -3-octyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-4-hexyloxy-3-octyloxy-1-ethyl-2(1H)-quinoline ketone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)- 4-butoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-1-ethyl-2(1H) -quinolinone, 7-nitro-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-geranyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy) -4-Hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3，4-二香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy- 1-Ethyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3,4-digeranyl Oxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-羟基-4-甲氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-乙基-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-1-乙基-2(1H)-喹啉酮，7-硝基-3，4-二羟基-1-乙基-2(1H)-喹啉酮，7-nitro-3-hydroxy-4-methoxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-butoxy-1-ethyl-2 (1H)-quinolinone, 7-nitro-3-hydroxyl-4-hexyloxy-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-ethyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-geranyloxy-1-ethyl-2(1H )-quinolinone, 7-nitro-3,4-dihydroxy-1-ethyl-2(1H)-quinolinone,

7-硝基-3-乙酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-乙氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-ethoxy-1- Butyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3- Acetoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butenyloxy) -1-Butyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-nitro Base-3-acetoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro -3-Formyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-formyloxy- 4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone ,

7-硝基-3，4-二甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-1-butyl- 2(1H)-quinolinone, 7-nitro-3-methoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-methoxy -4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-1 -Butyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-1-丁基-2(1 H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro Base-3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy -4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hydroxy-1-butyl-2(1H)-quinoline ketone,

7-硝基-3-丁氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-butyl- 2(1H)-quinolinone, 7-nitro-3-butoxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-butoxy -4-(3-Methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-1 -Butyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3，4-二己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-1- Butyl-2(1H)-quinolinone, 7-nitro-3,4-dihexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy -4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-1 -Butyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyl Oxy)-4-butoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-1-butanol Base-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-butyl-2 (1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-nitro -3-(2-methylpentyloxy)-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-辛氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-1- Butyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3- Octyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyloxy Base-1-butyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-1-丁基-2(1H)-喹啉酮7-硝基-3-(2-丙烯氧基)-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-1-butyl-2(1H)-quinolinone 7-nitro-3-(2-propenyloxy)-4 -Butoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-1-butyl-2(1H)- Quinolinone, 7-nitro-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7 -Nitro-3-(2-propenyloxy)-4-geranyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)- 4-Hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3，4-二香叶氧基-1-丁基-2(1H)-喹啉酮， 7-硝基-3-香叶氧基-4-羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy- 1-Butyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3,4-digeranyl Oxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-丁基-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-1-丁基-2(1H)-喹啉酮，7-硝基-3，4-二羟基-1-丁基-2(1H)-喹啉酮，7-nitro-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-butoxy-1-butyl-2 (1H)-quinolinone, 7-nitro-3-hydroxyl-4-hexyloxy-1-butyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-butyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-geranyloxy-1-butyl-2(1H )-quinolinone, 7-nitro-3,4-dihydroxy-1-butyl-2(1H)-quinolinone,

7-硝基-3-乙酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-乙氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-ethoxy-1-hexyl -2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-acetoxy -4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butenyloxy)-1-hexyl -2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-acetoxy Base-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy-1 -Hexyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3- Formyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-geranyl Oxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3，4-二甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-1-hexyl-2( 1H)-quinolinone, 7-nitro-3-methoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4- (3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-1-hexyl-2 (1H)-quinolinone, 7-nitro-3-methoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy-1 -Hexyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3- Isopropoxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-geranyl Oxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-丁氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-hexyl-2( 1H)-quinolinone, 7-nitro-3-butoxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4- (3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-1-hexyl-2 (1H)-quinolinone, 7-nitro-3-butoxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3，4-二己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-nitro-3,4-dihexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4- (3-Methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-1-hexyl-2 (1H)-quinolinone, 7-nitro-3-hexyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy Base)-4-butoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-1-hexyl-2 (1H)-Quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)- Quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2 -methylpentyloxy)-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-辛氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-1-hexyl -2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-octyloxy -4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyloxy-1- Hexyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-1--2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4 -Butoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-1--2(1H)-quinolinone , 7-nitro-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro- 3-(2-propenyloxy)-4-geranyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hydroxyl-1 -hexyl-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3，4-二香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy-1 -Hexyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3- Geranyloxy-4-(3-methyl-2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3,4-digeranyloxy-1 -hexyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-羟基-4-甲氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-己基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-己基-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-1-己基-2(1H)-喹啉酮，7-硝基-3，4-二羟基-1-己基-2(1H)-喹啉酮，7-nitro-3-hydroxy-4-methoxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-butoxy-1-hexyl-2(1H )-quinolinone, 7-nitro-3-hydroxyl-4-hexyloxy-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-(3-methyl -2-butenyloxy)-1-hexyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-geranyloxy-1-hexyl-2(1H)-quinolinone , 7-nitro-3,4-dihydroxy-1-hexyl-2(1H)-quinolinone,

7-硝基-3-乙酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-乙氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-乙酰氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-acetoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-ethoxy-1- Octyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-butoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3- Acetoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-(3-methyl-2-butenyloxy) -1-octyl-2(1H)-quinolinone, 7-nitro-3-acetoxy-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro Base-3-acetoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-甲酰氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲酰氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-formyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-butoxy- 1-octyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro -3-Formyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-formyloxy- 4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-formyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone ,

7-硝基-3，4-二甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基--3-甲氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-4-己氧基-3-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-甲氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3,4-dimethoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-butoxy-1-octyl -2(1H)-quinolinone, 7-nitro-3-hydroxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-4-hexyloxy- 3-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-methoxy-4-(3-methyl-2-butenyloxy)-1-octyl Base-2(1H)-quinolinone, 7-nitro-3-methoxy-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3- Methoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-异丙氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-异丙氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-isopropoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-butoxy- 1-octyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro -3-isopropoxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy- 4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-isopropoxy-4-hydroxy-1-octyl-2(1H)-quinolinone ,

7-硝基-3-丁氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3，4-二丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-丁氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-butoxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3,4-dibutoxy-1-octyl- 2(1H)-quinolinone, 7-nitro-3-butoxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-butoxy -4-(3-Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-geranyloxy-1 -octyl-2(1H)-quinolinone, 7-nitro-3-butoxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-己氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3，4-二己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-己氧基-4-羟基-1-辛-2(1H)-喹啉酮，7-nitro-3-hexyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-nitro-3,4-dihexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy -4-(3-Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-geranyloxy-1 -octyl-2(1H)-quinolinone, 7-nitro-3-hexyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-(2-甲基戊氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-甲基戊氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-(2-methylpentyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyl Oxy)-4-butoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-hexyloxy-1-octyl Base-2(1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2 (1H)-quinolinone, 7-nitro-3-(2-methylpentyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro -3-(2-methylpentyloxy)-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-辛氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-辛氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-octyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-butoxy-1- Octyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3- Octyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-geranyloxy Base-1-octyl-2(1H)-quinolinone, 7-nitro-3-octyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-(2-丙烯氧基)-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-(2-丙烯氧基)-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-(2-propenyloxy)-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)- 4-butoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-hexyloxy-1-octyl-2(1H) -quinolinone, 7-nitro-3-(2-propenyloxy)-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy)-4-geranyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-(2-propenyloxy) -4-Hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-香叶氧基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3，4-二香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-香叶氧基-4-羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-geranyloxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-butoxy- 1-octyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro -3-geranyloxy-4-(3-methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3,4-digeranyl Oxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-geranyloxy-4-hydroxy-1-octyl-2(1H)-quinolinone,

7-硝基-3-羟基-4-甲氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-羟基-4-丁氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-羟基-4-己氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3-羟基-4-(3-甲基-2-丁烯氧基)-1-辛基-2(1H)-喹啉酮，7-硝基-3-羟基-4-香叶氧基-1-辛基-2(1H)-喹啉酮，7-硝基-3，4-二羟基-1-辛基-2(1H)-喹啉酮，7-nitro-3-hydroxy-4-methoxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-butoxy-1-octyl-2 (1H)-quinolinone, 7-nitro-3-hydroxyl-4-hexyloxy-1-octyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-(3 -Methyl-2-butenyloxy)-1-octyl-2(1H)-quinolinone, 7-nitro-3-hydroxy-4-geranyloxy-1-octyl-2(1H )-quinolinone, 7-nitro-3,4-dihydroxy-1-octyl-2(1H)-quinolinone,

正如后面实例中所描述的，由于7-氨基喹啉酮衍生物以及生理学上可接受的盐类(下文中用“本发明化合物”来表示)对即发型及迟发型过敏反应均具有抑制作用，且其具有较低的毒性，它们在治疗和预防各种过敏性疾病时可用作抗过敏剂。As described in the following examples, since 7-aminoquinolinone derivatives and physiologically acceptable salts (hereinafter represented by "compounds of the present invention") have inhibitory effects on immediate and delayed hypersensitivity reactions, And they have low toxicity, they can be used as antiallergic agents in the treatment and prevention of various allergic diseases.

术语“过敏性疾病”是指由于外来的或内在的抗原引起生物免疫机制过分活跃所引起的过敏性疾病，其包括即发型哮喘，迟发型哮喘，支气管哮喘，小儿哮喘，异位性皮炎，过敏性皮炎，荨麻疹，湿疹，过敏性结膜炎，过敏性风湿，干草热，食物过敏，过敏性胃肠炎，过敏性结肠炎，接触性皮炎，自身免疫疾病等。The term "allergic disease" refers to an allergic disease caused by an overactive biological immune mechanism caused by foreign or internal antigens, including immediate asthma, delayed asthma, bronchial asthma, asthma in children, atopic dermatitis, allergic Dermatitis, urticaria, eczema, allergic conjunctivitis, allergic rheumatism, hay fever, food allergy, allergic gastroenteritis, allergic colitis, contact dermatitis, autoimmune diseases, etc.

包含本发明化合物作为活性成分的抗过敏剂可经口服(内服或吸入)或非肠道(例如静脉注射，皮下注射，透皮吸收，直肠给药等)途径给药。根据使用的目的不同，这种药剂可以制成不同的剂型，如片剂，胶囊，颗粒剂，细subtilaes，粉末剂，锭剂，舌下含片，栓剂，软膏剂，注射剂，乳化剂，悬浮液，药用糖浆等等。按照已知的技术，采用这种类型药物常用的且为制药学上可接受的载体，如赋形剂，粘合剂，崩解剂，润滑剂，防腐剂，抗氧剂，等渗剂，缓冲剂，包衣剂，甜味剂，溶解剂，基质，分散剂，稳定剂，增色剂等。The antiallergic agent comprising the compound of the present invention as an active ingredient can be administered orally (orally or by inhalation) or parenterally (eg, intravenous injection, subcutaneous injection, transdermal absorption, rectal administration, etc.). Depending on the purpose of use, this medicament can be made into different dosage forms, such as tablets, capsules, granules, fine subtilaes, powders, lozenges, sublingual tablets, suppositories, ointments, injections, emulsions, suspensions Liquids, medicinal syrups, etc. According to known technology, adopt the commonly used and pharmaceutically acceptable carrier of this type of medicine, as excipient, binding agent, disintegrant, lubricant, preservative, antioxidant, isotonic agent, Buffering agent, coating agent, sweetener, dissolving agent, matrix, dispersing agent, stabilizer, color enhancer, etc.

制药学上可接受的载体的实例列出于后。Examples of pharmaceutically acceptable carriers are listed below.

首先，可以列出下列赋形剂：淀粉及淀粉衍生物(如糊精，羧甲基淀粉等)，纤维素及纤维素衍生物(如甲基纤维素，羟丙甲基纤维素等)，糖类(如乳糖，果糖，葡萄糖等)，硅酸及硅酸盐(如天然存在的硅酸铝，硅酸镁等)，碳酸盐(如碳酸钙，碳酸镁，碳酸氢钠等)，氢氧化铝镁，合成hydrotalcite聚氧乙烯衍生物，单硬脂酸甘油酯单油酸山梨醇酯等。First, the following excipients can be listed: starch and starch derivatives (such as dextrin, carboxymethyl starch, etc.), cellulose and cellulose derivatives (such as methylcellulose, hydroxypropylmethylcellulose, etc.), Sugars (such as lactose, fructose, glucose, etc.), silicic acid and silicates (such as naturally occurring aluminum silicate, magnesium silicate, etc.), carbonates (such as calcium carbonate, magnesium carbonate, sodium bicarbonate, etc.), Aluminum magnesium hydroxide, synthetic hydrotalcite polyoxyethylene derivatives, glyceryl monostearate, sorbitan monooleate, etc.

粘合剂如下所列：淀粉和淀粉衍生物(如α淀粉，糊精等)，纤维素及纤维素衍生物(如乙基纤维素，羧甲基纤维素钠，羟丙甲基纤维素等)，阿拉伯胶，黄蓍胶，明胶，糖类(如葡萄糖，蔗糖等)，乙醇，聚乙烯醇等。Binders are listed below: starch and starch derivatives (such as α-starch, dextrin, etc.), cellulose and cellulose derivatives (such as ethyl cellulose, sodium carboxymethyl cellulose, hydroxypropyl methyl cellulose, etc. ), gum arabic, gum tragacanth, gelatin, sugars (such as glucose, sucrose, etc.), ethanol, polyvinyl alcohol, etc.

崩解剂如下所列：淀粉和淀粉衍生物(如羧甲基淀粉，羟丙基淀粉等)，纤维素及纤维素衍生物(如羧甲基纤维素钠，结晶纤维素，羟丙基甲基纤维素等)，碳酸盐(如碳酸钙，碳酸氢钙等)，黄蓍胶，明胶，琼脂等。Disintegrants are listed below: starch and starch derivatives (such as carboxymethyl starch, hydroxypropyl starch, etc.), cellulose and cellulose derivatives (such as sodium carboxymethyl cellulose, crystalline cellulose, hypromellose Base cellulose, etc.), carbonates (such as calcium carbonate, calcium bicarbonate, etc.), tragacanth gum, gelatin, agar, etc.

润滑剂如下所列：硬脂酸，硬脂酸钙，硬脂酸镁，滑石，硅酸及其盐(例如轻硅酸酐，天然硅酸铝盐等)，二氧化钛，磷酸氢钙，干氢氧化铝胶，大粒凝胶等。Lubricants are listed below: stearic acid, calcium stearate, magnesium stearate, talc, silicic acid and its salts (such as light silicic anhydride, natural aluminum silicate, etc.), titanium dioxide, calcium hydrogen phosphate, dry hydroxide Aluminum glue, large gel, etc.

防腐剂如下所列：对羟基苯甲酸盐，亚硫酸盐(如Na2SO3，吡咯亚硫酸钠等)，磷酸盐(如磷酸钠，聚磷酸钙，聚磷酸钠，偏磷酸钠等)，醇类(例如氯丁醇，苄醇等)，氯苄烷铵(洁尔灭)，氯苄，乙铵，苯酚，甲酚，氯甲酚，二羟乙酸，二羟己酸钠，山梨酸甘油酯，糖类等等。Preservatives are listed below: parabens, sulfites (such as Na 2 SO 3 , sodium pyrrole sulfite, etc.), phosphates (such as sodium phosphate, calcium polyphosphate, sodium polyphosphate, sodium metaphosphate, etc.), alcohols (e.g. chlorobutanol, benzyl alcohol, etc.), benzalkonium chloride (geeramine), benzyl chloride, ethyl ammonium, phenol, cresol, chlorocresol, glyoxylic acid, sodium dihydroxycaproate, glycerol sorbate esters, sugars, etc.

抗氧剂如下所列：亚硫酸盐(如亚硫酸钠，亚硫酸氢钠等等)，雕白粉，异抗坏血酸，L-抗坏血酸，半胱氨酸，硫代甘醇，丁基羟基茴香醚，二丁基羟基甲苯，丙基  酸，抗坏血棕榈酸酯，dl-α-生育酚等。Antioxidants are listed below: sulfites (such as sodium sulfite, sodium bisulfite, etc.), erythorbic acid, L-ascorbic acid, cysteine, thioglycol, butylated hydroxyanisole, dibutyl hydroxytoluene, propyl acid, ascorbyl palmitate, dl-α-tocopherol, etc.

等渗剂如下所列：氯化钠，硝酸钠，硝酸钾，糊精，甘油，葡萄糖等。Isotonic agents are listed below: sodium chloride, sodium nitrate, potassium nitrate, dextrin, glycerin, glucose, and the like.

缓冲剂如下所列：碳酸钠，盐酸，硼酸，磷酸盐(例如磷酸氢二钠)等。Buffering agents are listed below: sodium carbonate, hydrochloric acid, boric acid, phosphates (eg disodium hydrogen phosphate) and the like.

包衣剂如下所列：纤维素衍生物(例如羟丙基纤维素，纤维素乙酸酯邻苯二甲酸酯，羟丙基甲基纤维素邻苯二甲酸酯等)，紫胶，聚乙烯吡咯烷酮，聚乙烯吡啶(例如聚-2-乙烯吡啶，聚-2-乙烯-5-乙基吡啶等)，聚乙烯基乙酰基二乙基氨基乙酸酯，聚乙烯醇邻苯二甲酸酯，甲基丙烯酸酯，甲基丙烯酸酯共聚物等。Coating agents are listed below: cellulose derivatives (such as hydroxypropyl cellulose, cellulose acetate phthalate, hydroxypropyl methylcellulose phthalate, etc.), shellac, Polyvinylpyrrolidone, polyvinylpyridine (such as poly-2-vinylpyridine, poly-2-vinyl-5-ethylpyridine, etc.), polyvinylacetyl diethylaminoacetate, polyvinyl phthalate esters, methacrylates, methacrylate copolymers, etc.

甜味剂如下所列：糖类(例如葡萄糖，蔗糖，乳糖等)，糖精钠，糖醇类等。Sweeteners are listed below: sugars (such as glucose, sucrose, lactose, etc.), sodium saccharin, sugar alcohols, etc.

溶解剂如下所列：1，2-乙二胺，烟酰胺，糖精钠，柠檬酸，柠檬酸盐，苯甲酸钠，肥皂，聚乙烯吡咯烷酮，聚溶剂化物，山梨醇脂肪酸酯，甘油，聚乙二醇，苄醇等。Dissolving agents are listed below: ethylenediamine, niacinamide, sodium saccharin, citric acid, citrate, sodium benzoate, soap, polyvinylpyrrolidone, polysolvates, sorbitol fatty acid esters, glycerin, polyethylene glycol Diol, benzyl alcohol, etc.

基质如下所列：脂肪(如猪脂等)，植物油(例如橄榄油，芝麻油等)，动物油，羊毛脂酸，凡士林，石蜡，蜡，树脂，膨润土，甘油，甘醇油，高级醇类(例如硬脂基醇，十六烷醇)等等。Bases are listed below: fat (such as lard, etc.), vegetable oil (such as olive oil, sesame oil, etc.), animal oil, lanolin acid, petrolatum, paraffin, wax, resin, bentonite, glycerin, glycol oil, higher alcohols (such as stearyl alcohol, cetyl alcohol) and the like.

分散剂如下所列：阿拉伯胶，黄蓍胶，纤维素衍生物(如甲基纤维素等)，硬脂酸聚酯，倍半油酸山梨醇酯，单硬脂酸铝，藻酸钠，聚溶剂化物，山梨醇脂肪酸酯等。Dispersants are listed below: gum arabic, gum tragacanth, cellulose derivatives (such as methyl cellulose, etc.), polyester stearate, sorbitan sesquioleate, aluminum monostearate, sodium alginate, Polysolvates, sorbitan fatty acid esters, etc.

最后，稳定剂如下所列：亚硫酸盐(如亚硫酸氢钠等)，氮，二氧化碳等。Finally, stabilizers are listed below: sulfites (such as sodium bisulfite, etc.), nitrogen, carbon dioxide, etc.

本发明化合物在药物制剂中的含量取决于剂型，其浓度较好的是0.01～100％(重量比)。The content of the compound of the present invention in the pharmaceutical preparation depends on the dosage form, and its concentration is preferably 0.01-100% (weight ratio).

本发明中抗过敏剂的剂量可根据待治疗热血动物(包括人类)的种类，病情程度，医生的判断等因素在-个较宽的范围内变化。一般而言，口服给药时，给药剂量为0.01～50mg，较好的是0.01～10mg的活性成分/天/公斤体重，或者在非肠道给药时，给药剂量0.01～10mg、较好的是0.01～5mg活性成分/天/公斤体重。上述每日给药剂量根据病程程度及医生的判断可以一次给药，也可以分几次给药。The dose of the antiallergic agent in the present invention can be varied within a wide range according to the type of warm-blooded animal (including human) to be treated, the degree of disease, and the doctor's judgment. Generally speaking, during oral administration, the dosage is 0.01-50 mg, preferably 0.01-10 mg active ingredient/day/kg body weight, or during parenteral administration, the dosage is 0.01-10 mg, preferably 0.01-10 mg. Preferably, it is 0.01-5 mg active ingredient/day/kg body weight. The above-mentioned daily dosage can be administered once or several times according to the course of the disease and the doctor's judgment.

下文将概述本发明中7-氨基喹啉酮衍生物及7-硝基喹啉酮衍生物的制备方法。The preparation methods of 7-aminoquinolinone derivatives and 7-nitroquinolinone derivatives in the present invention will be outlined below.

根据下列反应路线及方法可以制备具通式的(I)7-氨基喹啉酮衍生物及可用于合成7-氨基喹啉酮的中间体且具通式II7-硝基喹啉酮衍生物，其中式(I)和式(II)中R1-R5的定义同前。Can prepare (I) 7-aminoquinolinone derivative with general formula and the intermediate that can be used for synthesizing 7-aminoquinolinone and have general formula II 7-nitroquinolinone derivative according to following reaction scheme and method, The definitions of R 1 -R 5 in formula (I) and formula (II) are the same as above.

作为第一步骤，将4-硝基氨茴酸乙酰化得到化合物(2)。此反应可用通常的乙酰化剂进行，例如乙酸酐或乙酰氯。反应温度为0℃～120℃，较好的是60～100℃。反应时间随酰化剂和反应温度而定，一般为0.5～3小时。虽然没有其它物质存在加速反应也能进行，但如能加入碱性物质将有助于加速反应。胺类是较好的碱性物质，如三乙胺，吡啶等。As a first step, 4-nitroanthranilic acid is acetylated to give compound (2). This reaction can be carried out with common acetylating agents such as acetic anhydride or acetyl chloride. The reaction temperature is 0°C to 120°C, preferably 60 to 100°C. The reaction time depends on the acylating agent and the reaction temperature, generally 0.5 to 3 hours. Although the accelerated reaction can be carried out without other substances, adding an alkaline substance will help to accelerate the reaction. Amines are better basic substances, such as triethylamine, pyridine, etc.

第二步，使用卤代烷作烷化剂，对上述化合物(2)进行烷基化反应。所用的碱的例子有无机盐，例如NaHCO3，NaCO3，K2CO3等以及醇化物类，例如乙醇钠，叔丁醇钾等，还有NaH。反应可在溶剂中进行。较好的溶剂包括烃类，如苯，甲苯等，醚溶剂，如乙醚，四氢呋喃，1，2-二甲氧基乙烷等，酰胺溶剂，例如N，N-二甲基甲酰胺等等。反应可在0-100℃之间进行，较好的是20-60℃，时间通常为1-5小时。当R1为氢时，则用下列环化反应代替上述烷基化反应。In the second step, the above-mentioned compound (2) is subjected to an alkylation reaction using an alkyl halide as an alkylating agent. Examples of bases used are inorganic salts such as NaHCO 3 , NaCO 3 , K 2 CO 3 etc. and alcoholates such as sodium ethoxide, potassium tert-butoxide etc. and also NaH. The reaction can be carried out in a solvent. Preferred solvents include hydrocarbons such as benzene, toluene, etc., ether solvents such as diethyl ether, tetrahydrofuran, 1,2-dimethoxyethane, etc., amide solvents such as N,N-dimethylformamide and the like. The reaction can be carried out at 0-100°C, preferably at 20-60°C, and the time is usually 1-5 hours. When R 1 is hydrogen, the following cyclization reaction is used instead of the above alkylation reaction.

第三步，所得的化合物(3)进行环合反应，得到化合物(4)。用碱性物质在有机溶剂中对化合物(3)进行处理来实施这一反应。较好的碱性物质包括醇化物如甲醇钠，乙醇钠，叔丁醇钾等，NaH，KH，二异丙基酰胺锂，双(三甲基甲硅烷基)酰胺锂等。反应可在溶剂中进行。较好的溶剂包括烃类，如苯，甲苯等，醇类溶剂，如甲醇，乙醇等，醚类溶剂，如乙醚，四氢呋喃，1，2-二甲氧乙烷等，酰胺类溶剂如N，N-二甲基甲酰胺等。反应温度为-50～100℃，较好的是0-50℃，时间一般为1-5小时。In the third step, the obtained compound (3) undergoes a ring closure reaction to obtain compound (4). This reaction is carried out by treating compound (3) with a basic substance in an organic solvent. Preferable alkaline substances include alcoholates such as sodium methoxide, sodium ethoxide, potassium tert-butoxide, etc., NaH, KH, lithium diisopropylamide, lithium bis(trimethylsilyl)amide, etc. The reaction can be carried out in a solvent. Preferred solvents include hydrocarbons, such as benzene, toluene, etc., alcohol solvents, such as methanol, ethanol, etc., ether solvents, such as ether, tetrahydrofuran, 1,2-dimethoxyethane, etc., amide solvents such as N, N-dimethylformamide, etc. The reaction temperature is -50-100°C, preferably 0-50°C, and the reaction time is generally 1-5 hours.

第四步，在化合物(4)的3位上进行酰氧化反应，所用的较好的氧化剂的实例包括有碘苯二乙酸酯等。此反应中，既可以通过与碘苯二乙酸酯在有机酸中反应直接获得所需化合物，也可以通过用有机酸处理须分离的碘鎓化合物来获得所需化合物。反应温度30-80℃，时间一般为2-5小时。In the fourth step, the acyl oxidation reaction is carried out on the 3-position of the compound (4). Examples of preferred oxidizing agents include iodobenzene diacetate and the like. In this reaction, the desired compound can be directly obtained by reacting with iodobenzene diacetate in an organic acid, or the desired compound can be obtained by treating the iodonium compound to be separated with an organic acid. The reaction temperature is 30-80°C, and the time is generally 2-5 hours.

下一步，为了要在化合物(5)上引入R2基团和R3基团，当R2基团为氢时，按常规的水解方法进行脱酰化反应，当R2基团和R3基团不为氢时，在引入适当的保护基后，进行烷基化反应或烯基化反应，然后进行去保护反应。较好的保护基的实例包括羟基保护基团，例如甲氧甲基基团。Next step, in order to introduce R2 group and R3 group on compound (5), when R2 group is hydrogen, carry out deacylation reaction according to conventional hydrolysis method, when R2 group and R3 When the group is not hydrogen, an alkylation or alkenylation reaction followed by a deprotection reaction is carried out after introduction of an appropriate protecting group. Examples of preferred protecting groups include hydroxy protecting groups such as methoxymethyl groups.

从而具式(II)的化合物便可制得。Thereby a compound of formula (II) can be prepared.

下一步，对所得的化合物(6)的硝基进行还原反应，制得化合物(7)，然后通过下述的烷基化反应或烯基化反应或芳烷基化反应获得化合物(8)。在实施这些烷基化反应或烯基化反应或芳烷基化反应时，当化合物(7)在3位或4位上具有羟基时，化合物上可引入合适的羟基保护基团。这一还原反应在有机溶剂中借助金属催化剂通过氢气的氢化反应来完成。金属催化剂包括钯、铂等催化剂，其用量为1-10％化合物的重量。在氢气下进行反应时，可以在加压状态或常压状态下。反应温度0-100℃，较好的为20-50℃，时间一般为1-5小时。此还原反应也可采用金属锡或锌来进行，从而可以获得具式(I)的化合物。In the next step, the nitro group of the obtained compound (6) is reduced to obtain the compound (7), and then the compound (8) is obtained through the following alkylation reaction, alkenylation reaction or aralkylation reaction. When carrying out these alkylation reactions, alkenylation reactions or aralkylation reactions, when the compound (7) has a hydroxyl group at the 3-position or 4-position, a suitable hydroxyl protecting group can be introduced into the compound. This reduction reaction is accomplished by hydrogenation with hydrogen over a metal catalyst in an organic solvent. Metal catalysts include catalysts such as palladium and platinum, and the amount thereof is 1-10% by weight of the compound. When the reaction is carried out under hydrogen, it may be under pressurized or normal pressure. The reaction temperature is 0-100°C, preferably 20-50°C, and the reaction time is generally 1-5 hours. This reduction reaction can also be carried out using metal tin or zinc, so that the compound of formula (I) can be obtained.

下列实例将进一步说明本发明，然而这些实例仅仅是想说明本发明，而不应看作限制本发明的范围。The following examples will further illustrate the present invention, however, these examples are only intended to illustrate the present invention and should not be construed as limiting the scope of the present invention.

参考实例1Reference example 1

2-乙酰基氨基-4-硝基-苯甲酸乙酯(化合物1)2-Acetylamino-4-nitro-benzoic acid ethyl ester (compound 1)

将4.45g4-硝基氨茴酸乙酯(21.2mmol)和9ml乙酸酐于90℃下搅拌1小时。减压浓缩反应混合物，残渣经CH2Cl2和己烷重结晶，得4.98g标题化合物(1)。(产率＝93％)4.45 g of ethyl 4-nitroanthraninate (21.2 mmol) and 9 ml of acetic anhydride were stirred at 90° C. for 1 hour. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from CH 2 Cl 2 and hexane to obtain 4.98 g of the title compound (1). (Yield = 93%)

1H-NMR(CDCl3，δ-TMS) 1 H-NMR (CDCl 3 , δ-TMS)

8.15(m，3H)，6.05(bs，1H)，4.43(q，2H，J＝7.0Hz)，1.82(s，3H)，1.41(t，3H)8.15(m, 3H), 6.05(bs, 1H), 4.43(q, 2H, J=7.0Hz), 1.82(s, 3H), 1.41(t, 3H)

IR(KBr，cm-1)：3240，2850，1740，1550，1345IR (KBr, cm -1 ): 3240, 2850, 1740, 1550, 1345

参考实例2Reference example 2

2-乙酰基氨甲基-4-硝基-苯甲酸乙酯(化合物2)2-Acetylaminomethyl-4-nitro-benzoic acid ethyl ester (compound 2)

将1.35g2-乙酰氨基-4-硝基苯甲酸乙酯(5.4mmol)溶于15mlDMF中，在冰浴冷却下，向其中加入220mgNaH(纯度60％，5.5mmol)，搅拌15分钟。加入1.50gCH3I(10.7mmol)，混合物再搅拌40分钟。向其中加苯和水，用苯提取。有机层在减压下浓缩，得到残渣用乙酸乙酯笔己烷重结晶，得1.16g标题化合物(2)。(产率＝81％)1.35g of ethyl 2-acetylamino-4-nitrobenzoate (5.4mmol) was dissolved in 15ml of DMF, and 220mg of NaH (purity 60%, 5.5mmol) was added thereto under ice-cooling, and stirred for 15 minutes. 1.50 g CH3I (10.7 mmol) was added and the mixture was stirred for a further 40 minutes. Add benzene and water to it and extract with benzene. The organic layer was concentrated under reduced pressure, and the obtained residue was recrystallized from ethyl acetate and hexane to obtain 1.16 g of the title compound (2). (Yield = 81%)

1H-NMR(CDCl3，δ-TMS) 1 H-NMR (CDCl 3 , δ-TMS)

8.15(m，3H)，4.43(q，2H，J＝，7.0Hz)，3.25(s，3H)，1.82(s，3H)，1.41(t，3H)8.15(m, 3H), 4.43(q, 2H, J=, 7.0Hz), 3.25(s, 3H), 1.82(s, 3H), 1.41(t, 3H)

IR(KBr，cm-1)：2850，1740，1550，1345IR (KBr, cm -1 ): 2850, 1740, 1550, 1345

参考实例3Reference example 3

7-硝基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物3)7-nitro-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 3)

将1.48g2-乙酰基甲氨基-4-硝基苯甲酸乙酯(5.6mmol)溶于9mlDMF中，冰浴冷却下向其中加入220mgNaH(纯度60％，5.5mmol)，搅拌过夜。混合物中加20ml水，用4N HCl酸化。生成的沉淀过滤并干燥，得0.96g标题化合物(3)。(产率＝78％)1.48g of ethyl 2-acetylmethylamino-4-nitrobenzoate (5.6mmol) was dissolved in 9ml of DMF, 220mg of NaH (purity 60%, 5.5mmol) was added thereto under ice-cooling, and stirred overnight. 20 ml of water were added to the mixture, which was acidified with 4N HCl. The resulting precipitate was filtered and dried to obtain 0.96 g of the title compound (3). (Yield = 78%)

1H-NMR(CDCl3，δ-TMS) 1 H-NMR (CDCl 3 , δ-TMS)

11.15(s，1H)，8.21(m，3H)，5.67(s，1H)，3.55(s，3H)IR(KBr，cm-1)：3275，1680，1555，134511.15(s, 1H), 8.21(m, 3H), 5.67(s, 1H), 3.55(s, 3H) IR(KBr, cm -1 ): 3275, 1680, 1555, 1345

实例1Example 1

7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物4)7-nitro-3-acetoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 4)

向9.72g7-硝基-4-羟基-1-甲基-2(1H)-喹啉酮(44.2mmol)的50mlCH2Cl2中加入14.0g碘苯二乙酸酯(43.5mmol)，室温下搅拌3小时。混合物过滤，减压浓缩滤液，得14.90g苯基碘鎓盐。向该盐中加150ml乙酸，70℃下搅拌3小时。减压浓缩混合物，生成的粗品用CH2Cl2洗涤，得6.98g标题化合物(4)。(产率＝56％)Add 14.0 g iodobenzene diacetate (43.5 mmol) to 9.72 g 7-nitro-4-hydroxy-1-methyl-2(1H)-quinolinone (44.2 mmol) in 50 ml CH 2 Cl 2 , at room temperature Stir for 3 hours. The mixture was filtered, and the filtrate was concentrated under reduced pressure to obtain 14.90 g of phenyliodonium salt. To this salt was added 150 ml of acetic acid, and stirred at 70°C for 3 hours. The mixture was concentrated under reduced pressure, and the resulting crude product was washed with CH 2 Cl 2 to obtain 6.98 g of the title compound (4). (Yield = 56%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.83(s，1H)，8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，3.68(s，3H)，2.30(s，3H)11.83(s, 1H), 8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 3.68(s, 3H), 2.30(s, 3H )

IR(KBr，cm-1)：3275，1745，1680，1555，1345IR (KBr, cm -1 ): 3275, 1745, 1680, 1555, 1345

元素分析(C12H10N2O6)Elemental Analysis (C 12 H 10 N 2 O 6 )

理论值(％)：C51.80；H3.62；N10.07；O34.51Theoretical value (%): C51.80; H3.62; N10.07; O34.51

实测值(％)：C51.75；H3.67；N10.26；O34.32Measured value (%): C51.75; H3.67; N10.26; O34.32

实例2Example 2

7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮(化合物5)7-nitro-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone (Compound 5)

向1.50g7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮(5.4mmol)的15mlDMF中加入1.12gK2CO3(8.1mmol)及0.76gCH3I(5.4mmol)，室温下搅拌3小时。反应混合物中加水，用苯提取。有机层减压浓缩得一粗品。硅胶柱层析(己烷/乙酸乙酯＝1/1作洗脱液)纯化，得0.68g标题化合物(5)。(产率＝43％)To 1.50 g 7-nitro-3-acetoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (5.4 mmol) in 15 ml DMF was added 1.12 g K 2 CO 3 (8.1 mmol) and 0.76 g CH 3 I (5.4 mmol), stirred at room temperature for 3 hours. Water was added to the reaction mixture, followed by extraction with benzene. The organic layer was concentrated under reduced pressure to obtain a crude product. Purification by silica gel column chromatography (hexane/ethyl acetate = 1/1 as eluent) gave 0.68 g of the title compound (5). (Yield = 43%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，4.32(s，3.68(s，3H)，2.30(s，3H)8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 4.32(s, 3.68(s, 3H), 2.30(s, 3H)

IR(KBr，cm-1)：1745，1680，1555，1345IR (KBr, cm -1 ): 1745, 1680, 1555, 1345

元素分析(C13H12N2O6)Elemental Analysis (C 13 H 12 N 2 O 6 )

理论值(％)：C53.53；H4.14；N9.59；O32.85Theoretical value (%): C53.53; H4.14; N9.59; O32.85

实测值(％)：C53.55；H4.05；N9.66；O32.74Measured value (%): C53.55; H4.05; N9.66; O32.74

实例3Example 3

7-氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮(化合物6)7-amino-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone (compound 6)

在氢气氛且室温下，将0.95g7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮(3.3mmol)和95mg10％Pd/c的20mlTHF溶液搅拌3小时。用氮气代替氢气后，过滤混合物，减压浓缩滤液，生成的残渣经硅胶柱层析(己烷/乙酸乙酯＝1/2作洗脱液)纯化，得0.75g标题化合物(6)。(产率＝87％)Under a hydrogen atmosphere at room temperature, 0.95 g of 7-nitro-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone (3.3 mmol) and 95 mg of 10% Pd/c The 20 ml THF solution was stirred for 3 hours. After replacing hydrogen with nitrogen, the mixture was filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane/ethyl acetate=1/2 as eluent) to obtain 0.75 g of the title compound (6). (Yield = 87%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，6.052H)，4.32(s，3H)，3.68(s，3H)，2.30(s，3H)7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 6.052H), 4.32(s, 3H), 3.68(s, 3H), 2.30 (s, 3H)

IR(KBr，cm-1)：3280，1745，1675，1250IR (KBr, cm -1 ): 3280, 1745, 1675, 1250

元素分析(C13H14N2O4)Elemental Analysis (C 13 H 14 N 2 O 4 )

理论值(％)：C59.53；H5.38；N10.68；O24.40Theoretical value (%): C59.53; H5.38; N10.68; O24.40

实测值(％)：C59.55；H5.45；N10.66；O24.34Measured value (%): C59.55; H5.45; N10.66; O24.34

实例4Example 4

7-硝基-3，4-二羟基-1-甲基-2(1H)-喹啉酮(化合物7)7-nitro-3,4-dihydroxy-1-methyl-2(1H)-quinolinone (Compound 7)

在冰浴冷却下，向2.56g7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮(9.2mmol)的50ml甲醇溶液中加入545mg甲醇钠(10.1mmol)的2.5ml甲醇溶液。搅拌1小时后，向其中加入4.4g大孔树脂(Am berlyst)，室温搅拌1小时。过滤混合物，减压浓缩滤液，残渣用THF和己烷重结晶，得1.75g标题化合物(7)。(产率＝81％)Under cooling in an ice bath, 545 mg of sodium methylate ( 10.1mmol) in 2.5ml methanol solution. After stirring for 1 hour, 4.4 g of macroporous resin (Amberlyst) was added thereto, and stirred at room temperature for 1 hour. The mixture was filtered, the filtrate was concentrated under reduced pressure, and the residue was recrystallized from THF and hexane to obtain 1.75 g of the title compound (7). (Yield = 81%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.18(s，1H)，10.85(s，1H)，8.05(m，3H)，3.68(s，3H)11.18(s, 1H), 10.85(s, 1H), 8.05(m, 3H), 3.68(s, 3H)

IR(KBr，cm-1)：3280，1605，1550，1345，1250IR (KBr, cm -1 ): 3280, 1605, 1550, 1345, 1250

元素分析(C10H8N2O5)Elemental analysis (C 10 H 8 N 2 O 5 )

理论值(％)：C50.81；H3.41；N11.86；O33.87Theoretical value (%): C50.81; H3.41; N11.86; O33.87

实测值(％)：C50.85；H3.45；N11.66；O34.04Measured value (%): C50.85; H3.45; N11.66; O34.04

实例5Example 5

7-氨基-3，4-二羟基-1-甲基-2(1H)-喹啉酮(化合物8)7-amino-3,4-dihydroxy-1-methyl-2(1H)-quinolinone (compound 8)

按照实例3所述方法，用7-硝基-3，4-二羟基-1-甲基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，得标题化合物(8)。(产率＝67％)According to the method described in Example 3, replace 7-nitro-3-acetoxy-4-methoxy with 7-nitro-3,4-dihydroxy-1-methyl-2(1H)-quinolinone -1-methyl-2(1H)-quinolinone to give the title compound (8). (Yield = 67%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，10.85(s，1H)，7.88(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.97(bs，2H)，3.65(s，3H)11.05(s, 1H), 10.85(s, 1H), 7.88(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.97(bs, 2H ), 3.65(s, 3H)

IR(KBr，cm-1)：3280，1605，1250IR (KBr, cm -1 ): 3280, 1605, 1250

元素分析Elemental analysis

理论值(％)：C58.25；H4.89；N13.58；O23.28Theoretical value (%): C58.25; H4.89; N13.58; O23.28

实测值(％)：C58.55；H4.75；N13.66；O23.04Measured value (%): C58.55; H4.75; N13.66; O23.04

实例6Example 6

7-甲氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮(化合物9)7-methylamino-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone (Compound 9)

向0.95g7-氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮(3.6mmol)的20mlDMF中加入0.55gK2CO3(4.0mmol)及0.56gCH3I(4.0mmol)，室温搅拌1小时。反应混合物中加水，用甲苯提取，有机层减压浓缩。残渣经硅胶柱层析纯化(己烷/乙酸乙酯＝1/1作洗脱液)，得0.45g标题化合物(9)。(产率＝45％)0.55g K 2 CO 3 (4.0mmol) and 0.56 gCH 3 I (4.0 mmol), stirred at room temperature for 1 hour. Water was added to the reaction mixture, extracted with toluene, and the organic layer was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate = 1/1 as eluent) to obtain 0.45 g of the title compound (9). (Yield = 45%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.86(s，1H)，4.32(s，3H)，3.68(s，3H)，3.45(s，3H)，2.30(s，3H)7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.86(s, 1H), 4.32(s, 3H), 3.68(s, 3H ), 3.45(s, 3H), 2.30(s, 3H)

IR(KBr，cm-1)：3280，1745，1675，1250IR (KBr, cm -1 ): 3280, 1745, 1675, 1250

元素分析(C14H16N2O4)Elemental Analysis (C 14 H 16 N 2 O 4 )

理论值(％)：C60.86；H5.84；N10.14；O23.16Theoretical value (%): C60.86; H5.84; N10.14; O23.16

实测值(％)：C60.76；H5.95；N10.26；O23.03Measured value (%): C60.76; H5.95; N10.26; O23.03

实例7Example 7

7-甲氨基-3-羟基-4-甲氧基-1-甲基-2(1H)-喹啉酮(化合物8)7-Methylamino-3-hydroxy-4-methoxy-1-methyl-2(1H)-quinolinone (Compound 8)

用与实例4相同的方法，以7-甲基氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(10)。(产率＝75％)Using the same method as Example 4, replace 7-nitro-3-acetoxy with 7-methylamino-3-acetoxy-4-methoxy-1-methyl-2(1H)-quinolinone -4-hydroxy-1-methyl-2(1H)-quinolinone to give the title compound (10). (Yield = 75%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.45(s，1H)，7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.86(s，1H)，4.32(s，3H)，3.68(s，3H)，3.45(s，3H)10.45(s, 1H), 7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.86(s, 1H), 4.32(s, 3H ), 3.68(s, 3H), 3.45(s, 3H)

IR(KBr，cm-1)：3280，1605，1250IR (KBr, cm -1 ): 3280, 1605, 1250

元素分析(C12H14N2O3)Elemental Analysis (C 12 H 14 N 2 O 3 )

理论值(％)：C61.52；H6.02；N11.96；O20.49Theoretical value (%): C61.52; H6.02; N11.96; O20.49

实测值(％)：C61.43；H5.98；N11.96；O20.63Measured value (%): C61.43; H5.98; N11.96; O20.63

实例8Example 8

7-硝基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮(化合物11)7-Nitro-3-acetoxy-4-hydroxy-2(1H)-quinolinone (compound 11)

按照实例1方法，用7-硝基-4-羟基-2(1H)-喹啉酮代替7-硝基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(11)。(产率＝61％)According to example 1 method, replace 7-nitro-4-hydroxyl-1-methyl-2(1H)-quinolinone with 7-nitro-4-hydroxyl-2(1H)-quinolinone to obtain the title compound (11). (Yield = 61%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.45(s，1H)，9.56(s，1H)，8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，2.30(s，3H)11.45(s, 1H), 9.56(s, 1H), 8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 2.30(s, 3H )

IR(KBr，cm-1)：3275，1745，1680，1555，1345IR (KBr, cm -1 ): 3275, 1745, 1680, 1555, 1345

元素分析(C11H8N2O6)Elemental Analysis (C 11 H 8 N 2 O 6 )

理论值(％)：C50.01；H3.05；N10.60；O36.34Theoretical value (%): C50.01; H3.05; N10.60; O36.34

实测值(％)：C50.23；H2.98；N10.46；O36.33Measured value (%): C50.23; H2.98; N10.46; O36.33

实例9Example 9

7-硝基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮(化合物12)7-Nitro-3-acetoxy-4-methoxy-2(1H)-quinolinone (compound 12)

按实例2方法，用7-硝基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(10)。(产率＝41％)。According to the method of example 2, replace 7-nitro-3-acetoxy-4-hydroxyl-1-methyl- 2(1H)-quinolinone to give the title compound (10). (Yield = 41%).

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d6-DMSO, δ-TMS)

9.56(s，1H)，8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，4.15(s，3H)，2.15(s，3H)9.56(s, 1H), 8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 4.15(s, 3H), 2.15(s, 3H )

IR(KBr，cm-1)：3245，1730，1650，1555，1345IR (KBr, cm -1 ): 3245, 1730, 1650, 1555, 1345

元素分析(C12H10N2O6)Elemental Analysis (C 12 H 10 N 2 O 6 )

理论值(％)：C51.80；H3.62；N10.07；O34.51Theoretical value (%): C51.80; H3.62; N10.07; O34.51

实测值(％)：C51.83；H3.58；N10.36；O34.23Measured value (%): C51.83; H3.58; N10.36; O34.23

实例10Example 10

7-硝基-3-羟基-4-甲氧基-2(1H)-喹啉酮(化合物13)7-nitro-3-hydroxy-4-methoxy-2(1H)-quinolinone (compound 13)

按实例4方法，用7-硝基-3-乙酰氧基-4-羟基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物((13)。(产率＝79％)According to the method of example 4, replace 7-nitro-3-acetoxy-4-hydroxyl-1-methyl- 2(1H)-quinolinone gave the title compound ((13). (Yield = 79%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，9.56(s，1H)，8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，4.15(s，3H)10.89(s, 1H), 9.56(s, 1H), 8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 4.15(s, 3H )

IR(KBr，cm-1)：3245，1600，1555，1345IR (KBr, cm -1 ): 3245, 1600, 1555, 1345

元素分析(C10H8N2O5)Elemental analysis (C 10 H 8 N 2 O 5 )

理论值(％)：C50.85；H3.41；N11.86；O33.87Theoretical value (%): C50.85; H3.41; N11.86; O33.87

实测值(％)：C50.83；H3.48；N11.76；O33.93Measured value (%): C50.83; H3.48; N11.76; O33.93

实例11Example 11

7-氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮(化合物14)7-Amino-3-hydroxy-4-methoxy-2(1H)-quinolinone (Compound 14)

按实例3方法，用7-硝基-3-羟基-4-甲氧基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，得到标题化合物(14)。(产率＝66％)According to the method of example 3, replace 7-nitro-3-acetoxyl group-4-methoxyl group with 7-nitro-3-hydroxyl group-4-methoxyl group-2(1H)-quinolinone-1-methyl -2(1H)-quinolinone to give the title compound (14). (Yield = 66%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，9.56(s，1H)，7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，10.89(s, 1H), 9.56(s, 1H), 7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d,

1H，J＝7.2Hz)，5.86(s，2H)，4.15(s，3H)1H, J=7.2Hz), 5.86(s, 2H), 4.15(s, 3H)

IR(KBr，cm-1)：3245，1605，1250IR (KBr, cm -1 ): 3245, 1605, 1250

元素分析(C10H10N2O3)Elemental Analysis (C 10 H 10 N 2 O 3 )

理论值(％)：C58.25；H4.89；N13.58；O23.28Theoretical value (%): C58.25; H4.89; N13.58; O23.28

实测值(％)：C58.28；H4.78；N13.76；O23.18Measured value (%): C58.28; H4.78; N13.76; O23.18

实例12Example 12

7-氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮(化合物15)7-amino-3-acetoxy-4-methoxy-2(1H)-quinolinone (compound 15)

按实例3方法，用7-硝基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮，得标题化合物(15)。(产率＝66％)According to example 3 method, replace 7-nitro-3-acetoxyl group-4-methoxyl group with 7-nitro-3-acetoxyl group-4-methoxyl group-2 (1H)-quinolinone -Methyl-2(1H)-quinolinone to give the title compound (15). (Yield = 66%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

9.56(s，1H)，7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.86(s，2H)，4.15(s，3H)，2.14(s，3H)9.56(s, 1H), 7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.86(s, 2H), 4.15(s, 3H ), 2.14(s, 3H)

IR(KBr，cm-1)：3245，1730，1680，1250IR (KBr, cm -1 ): 3245, 1730, 1680, 1250

元素分析(C12H12N2O4)Elemental Analysis (C 12 H 12 N 2 O 4 )

理论值(％)：C58.06；H4.87；N11.29；O25.78Theoretical value (%): C58.06; H4.87; N11.29; O25.78

实测值(％)：C58.18；H4.88；N11.16；O25.78Measured value (%): C58.18; H4.88; N11.16; O25.78

实例13Example 13

7-丁氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮(化合物16)7-Butylamino-3-acetoxy-4-methoxy-2(1H)-quinolinone (Compound 16)

按实例6方法，用7-氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮和丁基碘代替7-氨基-3-乙酰氧基-4-甲氧基-1-甲基-2(1H)-喹啉酮和碘甲烷，得标题化合物(16)。(产率＝75％)According to the method of example 6, replace 7-amino-3-acetoxy-4-methoxy with 7-amino-3-acetoxy-4-methoxy-2(1H)-quinolinone and butyl iodide -1-methyl-2(1H)-quinolinone and methyl iodide to give the title compound (16). (Yield = 75%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

9.56(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，6.04(m，1H)，4.15(s，3H)，3.34(m，2H，J＝7.5Hz)，2.14(s，3H)，1.80～1.35(m，4H)，0.96(t，3H，J＝7.5Hz)9.56(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 6.04(m, 1H), 4.15(s, 3H ), 3.34(m, 2H, J=7.5Hz), 2.14(s, 3H), 1.80～1.35(m, 4H), 0.96(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1734，1680，1250IR (KBr, cm -1 ): 3245, 1734, 1680, 1250

元素分析(C16H20N2O4)Elemental Analysis (C 16 H 20 N 2 O 4 )

理论值(％)：C63.14；H6.62；N9.21；O21.03Theoretical value (%): C63.14; H6.62; N9.21; O21.03

实测值(％)：C63.18；H6.88；N9.16；O20.78Measured value (%): C63.18; H6.88; N9.16; O20.78

实例14Example 14

7-丁基氨基-3-羟基-4-甲氧基-2(1H)-喹啉酮(化合物17)7-Butylamino-3-hydroxy-4-methoxy-2(1H)-quinolinone (compound 17)

按实例4方法，以7-丁氨基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(17)。(产率＝84％)According to the method of example 4, replace 7-nitro-3-acetoxyl group-4-hydroxyl group with 7-butylamino-3-acetoxyl group-4-methoxyl group-2(1H)-quinolinone base-2(1H)-quinolinone to give the title compound (17). (Yield = 84%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，9.56(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，6.04(m，1H)，4.15(s，3H)，3.34(m，2H，J＝7.5Hz)，1.80～1.35(m，4H)，0.96(t，3H，J＝7.5Hz)10.89(s, 1H), 9.56(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 6.04(m, 1H ), 4.15(s, 3H), 3.34(m, 2H, J=7.5Hz), 1.80～1.35(m, 4H), 0.96(t, 3H, J=7.5Hz)

元素分析(C14H18N2O3)Elemental Analysis (C 14 H 18 N 2 O 3 )

理论值(％)：C64.10；H6.92；N10.68；O18.30Theoretical value (%): C64.10; H6.92; N10.68; O18.30

实测值(％)：C64.18；H6.98；N10.56；O18.28Measured value (%): C64.18; H6.98; N10.56; O18.28

实例15Example 15

7-硝基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物18)7-nitro-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 18)

将1.87g三乙胺(18.5mmol)加到3.2g7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮(11.5mmol)的64mlTHF溶液中后，将1.89g氯甲基甲基醚(23.0mmol)滴加到混合物中，室温搅拌1小时。过滤反应物，滤液减压浓缩得3.6g7-硝基-3-乙酰氧基-4-甲氧基甲氧基-1-甲基-2(1H)-喹啉酮。按实例4方法，用7-硝基-3-乙酰氧基-4-甲氧基甲氧基-1-甲基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，可以获得7-硝基-3-羟基-4-甲氧基甲氧基-1-甲基-2(1H)-喹啉酮。然后按实例2方法，通过甲基化反应得到7-硝基-3-甲氧基-4-甲氧基甲氧基-1-甲基-2(1H)-喹啉酮。最后向所得的7-硝基-3-甲氧基-4-甲氧基甲氧基-1-甲基-2(1H)-喹啉酮的40ml甲醇溶液中加入0.22g对甲苯磺酸单水合物，并在室温搅拌1小时。向反应混合物中加水，用乙酸乙酯提取，有机层减压浓缩。残渣用THF和己烷重结晶得1.45g标题化合物(18)。(产率＝54％)After adding 1.87g triethylamine (18.5mmol) to 3.2g 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone (11.5mmol) in 64mlTHF solution , 1.89 g of chloromethyl methyl ether (23.0 mmol) was added dropwise to the mixture, and stirred at room temperature for 1 hour. The reactant was filtered, and the filtrate was concentrated under reduced pressure to obtain 3.6 g of 7-nitro-3-acetoxy-4-methoxymethoxy-1-methyl-2(1H)-quinolinone. According to the method of example 4, replace 7-nitro-3-acetoxy with 7-nitro-3-acetoxy-4-methoxymethoxy-1-methyl-2(1H)-quinolinone -4-Hydroxy-1-methyl-2(1H)-quinolinone, 7-nitro-3-hydroxyl-4-methoxymethoxy-1-methyl-2(1H)-quinolinone can be obtained Linone. Then according to the method of Example 2, 7-nitro-3-methoxy-4-methoxymethoxy-1-methyl-2(1H)-quinolinone was obtained by methylation reaction. Finally, add 0.22 g p-toluenesulfonic acid mono hydrate and stir at room temperature for 1 hour. Water was added to the reaction mixture, extracted with ethyl acetate, and the organic layer was concentrated under reduced pressure. The residue was recrystallized from THF and hexane to obtain 1.45 g of the title compound (18). (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.29(s，1H)，8.27(s，1H)，8.18(d，1H，J＝7.2Hz)，8.01(d，1H，J＝7.2Hz)，3.98(s，3H)，3.56(s，3H)11.29(s, 1H), 8.27(s, 1H), 8.18(d, 1H, J=7.2Hz), 8.01(d, 1H, J=7.2Hz), 3.98(s, 3H), 3.56(s, 3H )

IR(KBr，cm-1)：3245，1600，1550，1345，1250IR (KBr, cm -1 ): 3245, 1600, 1550, 1345, 1250

元素分析(C11H10N2O4)Elemental Analysis (C 11 H 10 N 2 O 4 )

理论值(％)：C52.80；H4.03；N11.20；O31.97Theoretical value (%): C52.80; H4.03; N11.20; O31.97

实测值(％)：C52.67；H3.98；N11.56；O31.79Measured value (%): C52.67; H3.98; N11.56; O31.79

实例16Example 16

7-氨基-3-甲氧-4-羟基-1-甲基-2(1H)-喹啉酮(化合物19)7-Amino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 19)

按实例3方法，以7-硝基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-甲氧基-2(1H)-喹啉酮，得标题化合物(19)。(产率＝78％)According to the method of example 3, replace 7-nitro-3-acetoxy-4-methoxy with 7-nitro-3-methoxyl-4-hydroxyl-1-methyl-2(1H)-quinolinone base-2(1H)-quinolinone to give the title compound (19). (Yield = 78%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.08(s，3H)，3.54(s，3H)10.89(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.08(s, 3H ), 3.54(s, 3H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C11H12N2O3)Elemental Analysis (C 11 H 12 N 2 O 3 )

理论值(％)：C59.99；H5.49；N12.72；O21.80Theoretical value (%): C59.99; H5.49; N12.72; O21.80

实测值(％)：C60.01；H5.45；N12.68；O21.86Measured value (%): C60.01; H5.45; N12.68; O21.86

实例17Example 17

7-氨基-3-乙酰氧基-4-乙氧基-1-甲基-2(1H)-喹啉酮(化合物20)7-amino-3-acetoxy-4-ethoxy-1-methyl-2(1H)-quinolinone (compound 20)

按实例2和3的方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用碘乙烷代替碘甲烷，得标题化合物(20)。(产率＝56％)According to the method of example 2 and 3, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with ethyl iodide, obtain the title compound ( 20). (Yield = 56%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

7.95(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，6.00(bs，2H)，4.12(t，2H，J＝7.5Hz)，3.58(s，3H)，2.30(s，3H)，0.98(t，3H，J＝7.5Hz)7.95(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 6.00(bs, 2H), 4.12(t, 2H, J=7.5Hz), 3.58(s, 3H), 2.30(s, 3H), 0.98(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1745，1600，1245IR (KBr, cm -1 ): 3245, 1745, 1600, 1245

元素分析(C14H16N2O4)Elemental Analysis (C 14 H 16 N 2 O 4 )

理论值(％)：C60.86；H5.84；N10.14；O23.16Theoretical value (%): C60.86; H5.84; N10.14; O23.16

实测值(％)：C60.85；H5.95；N9.96；O23.24Measured value (%): C60.85; H5.95; N9.96; O23.24

实例18Example 18

7-氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物21)7-Amino-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 21)

按实例15和3的方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用碘己烷代替碘甲烷，得标题化合物(21)。(产率＝54％)According to the method of Example 15 and 3, using 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replacing methyl iodide with iodohexane, the title compound ( twenty one). (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.23(d，2H，J＝7.6Hz)，3.54(s，3H)，1.98～1.45(m，8H)，1.05(t，3H，J＝7.5Hz)10.89(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.23(d, 2H , J=7.6Hz), 3.54(s, 3H), 1.98～1.45(m, 8H), 1.05(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3200，1590，1220，1100IR (KBr, cm -1 ): 3200, 1590, 1220, 1100

元素分析(C16H22N2O3)Elemental Analysis (C 16 H 22 N 2 O 3 )

理论值(％)：C66.18；H7.64；N9.65；O16.53Theoretical value (%): C66.18; H7.64; N9.65; O16.53

实测值(％)：C66.18；H7.58；N9.56；O16.68Measured value (%): C66.18; H7.58; N9.56; O16.68

实例19Example 19

7-氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物22)7-Amino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 22)

按实例15和3方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用碘辛烷代替碘甲烷，得标题化合物(22)。(产率＝47％)According to example 15 and 3 method, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodooctane, obtain title compound (22 ). (Yield = 47%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.23(s，1H)，7.92(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.23(d，2H，J＝7.6Hz)，3.54(s，3H)，1.86～1.45(m，12H)，0.97(t，3H，J＝7.5Hz)11.23(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.23(d, 2H , J=7.6Hz), 3.54(s, 3H), 1.86～1.45(m, 12H), 0.97(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3200，1595，1230，1100IR (KBr, cm -1 ): 3200, 1595, 1230, 1100

元素分析(C18H26N2O3)Elemental Analysis (C 18 H 26 N 2 O 3 )

理论值(％)：C67.90；H8.23；N8.80；O15.08Theoretical value (%): C67.90; H8.23; N8.80; O15.08

实测值(％)：C67.86；H8.38；N8.96；O14.80Measured value (%): C67.86; H8.38; N8.96; O14.80

实例20Example 20

7-氨基-3-羟基-4-己氧基-1-甲基-2(1H)-喹啉酮(化合物23)7-Amino-3-hydroxy-4-hexyloxy-1-methyl-2(1H)-quinolinone (compound 23)

按实例2，3和4方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以碘己烷代替碘甲烷，得标题化合物(23)。(产率＝54％)According to example 2, 3 and 4 method, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodohexane, obtain the title compound (twenty three). (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.23(d，2H，J＝7.6Hz)，3.54(s，3H)，1.87～1.45(m，8H)，1.02(t，3H，J＝7.5Hz)11.05(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.23(d, 2H , J=7.6Hz), 3.54(s, 3H), 1.87～1.45(m, 8H), 1.02(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C16H22N2O3)Elemental Analysis (C 16 H 22 N 2 O 3 )

理论值(％)：C66.18；H7.64；N9.65；O16.53Theoretical value (%): C66.18; H7.64; N9.65; O16.53

实测值(％)：C66.13；H7.58；N9.56；O16.73Measured value (%): C66.13; H7.58; N9.56; O16.73

实例21Example 21

7-辛氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物24)7-octylamino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 24)

按实例3，6和15方法使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用碘辛烷代替碘甲烷作为氨基基团的烷基化试剂，得标题化合物(24)。(产率＝54％)Use 7-nitro-3-acetoxyl group-4-hydroxyl-1-methyl-2(1H)-quinolinone according to example 3, 6 and 15 methods, replace iodomethane with iodooctane as amino group Alkylation reagent, the title compound (24) was obtained. (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.，78(m，1H)，4.23(s，3H)，3.54(s，3H)，3.45(t，2H，J＝7.5Hz)，1.87～1.45(m，12H)，1.02(t，3H，J＝7.5Hz)11.05(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5., 78(m, 1H), 4.23( s, 3H), 3.54(s, 3H), 3.45(t, 2H, J=7.5Hz), 1.87～1.45(m, 12H), 1.02(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C19H28N2O3)Elemental Analysis (C 19 H 28 N 2 O 3 )

理论值(％)：C68.64；H8.49；N8.43；O14.44Theoretical value (%): C68.64; H8.49; N8.43; O14.44

实测值(％)：C68.53；H8.58；N8.56；O14.33Measured value (%): C68.53; H8.58; N8.56; O14.33

实例22Example 22

7-二甲氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物25)7-Dimethylamino-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 25)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用碘己烷代替碘甲烷作烷基化试剂，得标题化合物(25)。(产率＝45％)According to example 3, 6 and 15 methods, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodohexane for alkylation Reagents, the title compound (25) was obtained. (Yield = 45%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，4.23(t，2H，J＝7.8Hz)，3.54(s，3H)，3.45(s，6H)，1.87～1.45(m，8H)，0.98(t，3H，J＝7.5Hz)11.05(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 4.23(t, 2H, J=7.8Hz), 3.54(s, 3H), 3.45(s, 6H), 1.87～1.45(m, 8H), 0.98(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C18H26N2O3)Elemental Analysis (C 18 H 26 N 2 O 3 )

理论值(％)：C67.90；H8.23；N8.80；O15.08Theoretical value (%): C67.90; H8.23; N8.80; O15.08

实测值(％)：C67.83；H8.38；N8.66；O15.13Measured value (%): C67.83; H8.38; N8.66; O15.13

实例23Example 23

7-甲氧基-3-羟基-4-辛氧基-1-甲基-2(1H)-喹啉酮(化合物26)7-methoxy-3-hydroxy-4-octyloxy-1-methyl-2(1H)-quinolinone (compound 26)

按实例2，3和6方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以碘辛烷代替碘甲烷作烷基化试剂，得标题化合物(26)。(产率＝58％)According to example 2, 3 and 6 method, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodooctane for alkylation Reagents, the title compound (26) was obtained. (Yield = 58%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.45(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.76(m，1H)，4.13(t，2H，J＝7.8Hz)，3.56(s，3H)，3.43(s，3H)，1.87～1.45(m，12H)，0.98(t，3H，J＝7.5Hz)10.45(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.76(m, 1H), 4.13(t, 2H , J=7.8Hz), 3.56(s, 3H), 3.43(s, 3H), 1.87～1.45(m, 12H), 0.98(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C19H28N2O3)Elemental Analysis (C 19 H 28 N 2 O 3 )

理论值(％)：C68.64；H8.49；N8.43；O14.44Theoretical value (%): C68.64; H8.49; N8.43; O14.44

实测值(％)：C68.83；H8.48；N8.46；O14.23Measured value (%): C68.83; H8.48; N8.46; O14.23

实例24Example 24

7-己氨基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物27)7-Hexylamino-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 27)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以碘烷代替碘甲烷作烷基化试剂，得标题化合物(27)。(产率＝48％)According to example 3, 6 and 15 methods, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodane as alkylating reagent , to obtain the title compound (27). (Yield = 48%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.45(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.65(m，1H)，4.23(s，3H)，3.56(s，3H)，3.43(m，2H)，1.87～1.45(m，8H)，0.98(t，3H，J＝7.5Hz)11.45(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.65(m, 1H), 4.23(s, 3H ), 3.56(s, 3H), 3.43(m, 2H), 1.87～1.45(m, 8H), 0.98(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C17H24N2O3)Elemental Analysis (C 17 H 24 N 2 O 3 )

理论值(％)：C67.08；H7.95；N9.20；O15.77Theoretical value (%): C67.08; H7.95; N9.20; O15.77

实测值(％)：C67.05；H7.88；N9.36；O15.71Measured value (%): C67.05; H7.88; N9.36; O15.71

实例25Example 25

7-丁氨基-3-羟基-4-己氧基-1-甲基-2(1H)-喹啉酮(化合物28)7-Butylamino-3-hydroxy-4-hexyloxy-1-methyl-2(1H)-quinolinone (compound 28)

按实例2，3和6方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以碘丁烷代替碘甲烷作烷基化试剂，得标题化合物(28)。(产率＝52％)According to example 2, 3 and 6 method, use 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodobutane for alkylation Reagents, the title compound (28) was obtained. (Yield = 52%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.45(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.75(m，1H)，4.23(t，2H，J＝7.6Hz)，3.56(s，3H)，3.43(m，2H)，1.87～1.45(m，12H)，0.95(m，6H)10.45(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.75(m, 1H), 4.23(t, 2H , J=7.6Hz), 3.56(s, 3H), 3.43(m, 2H), 1.87～1.45(m, 12H), 0.95(m, 6H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C20H30N2O3)Elemental Analysis (C 20 H 30 N 2 O 3 )

理论值(％)：C69.33；H8.73；N8.09；O13.85Theoretical value (%): C69.33; H8.73; N8.09; O13.85

实测值(％)：C69.23；H8.88；N8.26；O13.63Measured value (%): C69.23; H8.88; N8.26; O13.63

实例26Example 26

7-甲氨基-3-(2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮(化合物29)7-methylamino-3-(2-propenyloxy)-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 29)

按实例15，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以烯丙基溴代替碘甲烷作烷基化试剂，得7-硝基-3-(2-丙烯氧基)-4-羟基-1-甲基-2(1H)-喹啉酮。光谱数据如下所列。According to Example 15, using 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replacing methyl iodide with allyl bromide as the alkylating reagent, to give 7 -nitro-3-(2-propenyloxy)-4-hydroxy-1-methyl-2(1H)-quinolinone. Spectral data are listed below.

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，8.05(m，3H)，5.90(m，1H)，5.355.20(m，2H)，4.57(d，2H，J＝2.0Hz)，3.68(s，3H)11.05(s, 1H), 8.05(m, 3H), 5.90(m, 1H), 5.355.20(m, 2H), 4.57(d, 2H, J=2.0Hz), 3.68(s, 3H)

IR(KBr，em-1)：3280，1605，1550，1345，1250IR (KBr, em -1 ): 3280, 1605, 1550, 1345, 1250

元素分析(C13H12N2O5)Elemental Analysis (C 13 H 12 N 2 O 5 )

理论值(％)：C56.52；H4.38；N10.14；O28.96Theoretical value (%): C56.52; H4.38; N10.14; O28.96

实测值(％)：C56.43；H4.48；N10.16；O28.93Measured value (%): C56.43; H4.48; N10.16; O28.93

按实例3和6方法，使用上述制得的产品，得标题化合物(29)。(产率＝49％)The title compound (29) was obtained according to the methods of Examples 3 and 6 using the product obtained above. (Yield = 49%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.25(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.92(m，1H)，5.75(m，1H)，5.25(m，2H)，4.58(d，2H，J＝2.0Hz)，3.56(s，3H)，3.43(s，3H)11.25(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.92(m, 1H), 5.75(m, 1H ), 5.25(m, 2H), 4.58(d, 2H, J=2.0Hz), 3.56(s, 3H), 3.43(s, 3H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C14H16N2O3)Elemental Analysis (C 14 H 16 N 2 O 3 )

理论值(％)：C64.60；H6.20；N10.76；O18.44Theoretical value (%): C64.60; H6.20; N10.76; O18.44

实测值(％)：C64.43；H6.48；N10.56；O18.53Measured value (%): C64.43; H6.48; N10.56; O18.53

实例27Example 27

7-甲氨基-3-异戊二烯氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物30)7-Methylamino-3-prenyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 30)

按实例26方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以异戊二烯基溴代替烯丙基溴作烷基化试剂，得标题化合物(30)。(产率＝64％)According to the method of example 26, using 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replacing allyl bromide with isoprenyl bromide as the alkyl group Reagents were used to obtain the title compound (30). (Yield = 64%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.25(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.75(m，1H)，5.35(m，1H)，4.56(d，2H，J＝2.0Hz)，3.56(s，3H)，3.43(s，3H)，1.75(s，3H)，1.70(s，3H)11.25(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.75(m, 1H), 5.35(m, 1H ), 4.56(d, 2H, J=2.0Hz), 3.56(s, 3H), 3.43(s, 3H), 1.75(s, 3H), 1.70(s, 3H)

IR(KBr，cm-1)：3245，1680，1250IR (KBr, cm -1 ): 3245, 1680, 1250

元素分析(C16H20N2O3)Elemental Analysis (C 16 H 20 N 2 O 3 )

理论值(％)：C66.64；H6.99；N9.72；O16.65Theoretical value (%): C66.64; H6.99; N9.72; O16.65

实测值(％)：C66.43；H6.98；N9.87；O16.72Measured value (%): C66.43; H6.98; N9.87; O16.72

实例28Example 28

7-甲氨基-3-香叶氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物31)7-Methylamino-3-geranyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 31)

按实例26方法，采用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以香叶基溴代替烯丙基溴作烷基化试剂，得标题化合物(31)。(产率＝58％)According to the method of example 26, using 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replacing allyl bromide with geranyl bromide as an alkylating reagent , to obtain the title compound (31). (Yield = 58%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.25(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.75(m，1H)，5.35(m，1H)，5.10(m，1H)，4.57(d，2H，J＝2.8Hz)，3.53(s，3H)，3.43(s，3H)，2.10(m，4H)，1.75(s，3H)，1.68(s，3H)，1.60(s，3H)11.25(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.75(m, 1H), 5.35(m, 1H ), 5.10(m, 1H), 4.57(d, 2H, J=2.8Hz), 3.53(s, 3H), 3.43(s, 3H), 2.10(m, 4H), 1.75(s, 3H), 1.68 (s, 3H), 1.60 (s, 3H)

IR(KBr，cm-1)：3245，1605，1250IR (KBr, cm -1 ): 3245, 1605, 1250

元素分析(C21H28N2O3)Elemental Analysis (C 21 H 28 N 2 O 3 )

理论值(％)：C70.76；H7.92；N7.86；O13.47Theoretical value (%): C70.76; H7.92; N7.86; O13.47

实测值(％)：C70.73；H7.98；N7.87；O13.42Measured value (%): C70.73; H7.98; N7.87; O13.42

实例29Example 29

7-氨基-3-己氧基-4-羟基-1-乙基-2(1H)-喹啉酮(化合物32)7-Amino-3-hexyloxy-4-hydroxy-1-ethyl-2(1H)-quinolinone (Compound 32)

按实例15和3方法，采用7-硝基-3-乙酰氧基-4-羟基-1-乙基-2(1H)-喹啉酮，以碘己烷代替碘甲烷，得标题化合物(32)。(产率＝54％)According to example 15 and 3 method, adopt 7-nitro-3-acetoxy group-4-hydroxyl-1-ethyl-2(1H)-quinolinone, replace methyl iodide with iodomethane, obtain title compound (32 ). (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.23(d，2H，J＝7.6Hz)，3.54(d，2H，J＝7.8Hz)，1.98～1.45(m，8H)，1.05(m，6H)10.89(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.23(d, 2H , J=7.6Hz), 3.54(d, 2H, J=7.8Hz), 1.98～1.45(m, 8H), 1.05(m, 6H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C17H24N2O3)Elemental Analysis (C 17 H 24 N 2 O 3 )

理论值(％)：C67.08；H7.95；N9.20；O15.77Theoretical value (%): C67.08; H7.95; N9.20; O15.77

实测值(％)：C67.18；H7.88；N9.26；O15.68Measured value (%): C67.18; H7.88; N9.26; O15.68

实例30Example 30

7-氨基-3-羟基-4-丁氧基-1-丙基-2(1H)-喹啉酮(化合物33)7-Amino-3-hydroxy-4-butoxy-1-propyl-2(1H)-quinolinone (compound 33)

按实例2和3所述方法，使用7-硝基-3-乙酰氧基-4-羟基-1-丙基-2(1H)-喹啉酮，以碘丁烷代替碘甲烷，得标题化合物(33)。(产率＝46％)According to the method described in Examples 2 and 3, using 7-nitro-3-acetoxy-4-hydroxyl-1-propyl-2(1H)-quinolinone, substituting iodobutane for methyl iodide, the title compound was obtained (33). (Yield = 46%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.25(d，2H，J＝7.6Hz)，3.54(d，2H，J＝7.8Hz)，1.98～1.45(m，6H)，1.05(m，6H)10.89(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.25(d, 2H , J=7.6Hz), 3.54(d, 2H, J=7.8Hz), 1.98～1.45(m, 6H), 1.05(m, 6H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C16H22N2O3)Elemental Analysis (C 16 H 22 N 2 O 3 )

理论值(％)：C66.18；H7.64；N9.65；O16.53Theoretical value (%): C66.18; H7.64; N9.65; O16.53

实测值(％)：C66.08；H7.78；N9.46；O16.68Measured value (%): C66.08; H7.78; N9.46; O16.68

实例31Example 31

7-氨基-3-羟基-4-癸氧基-1-丙基-2(1H)-喹啉酮(化合物34)7-amino-3-hydroxy-4-decyloxy-1-propyl-2(1H)-quinolinone (compound 34)

按实例2和3方法，使用7-硝基-3-乙酰氧基-4-羟基-1-丙基-2(1H)-喹啉酮，以碘癸烷代替碘甲烷，得标题化合物(34)。(产率＝46％)According to the method of example 2 and 3, using 7-nitro-3-acetoxy-4-hydroxyl-1-propyl-2(1H)-quinolinone, replacing methyl iodide with iododecane, the title compound (34 ). (Yield = 46%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.89(s，1H)，7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.25(d，2H，J＝7.6Hz)，3.54(d，2H，J＝7.8Hz)，2.04～1.23(m，18H)，1.05(m，6H)10.89(s, 1H), 7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.25(d, 2H , J=7.6Hz), 3.54(d, 2H, J=7.8Hz), 2.04～1.23(m, 18H), 1.05(m, 6H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C22H34N2O3 Elemental analysis (C 22 H 34 N 2 O 3

理论值(％)：C70.55；H9.15；N7.48；O12.82Theoretical value (%): C70.55; H9.15; N7.48; O12.82

实测值(％)：C70.53；H8.98；N7.46；O13.03Measured value (%): C70.53; H8.98; N7.46; O13.03

实例32Example 32

7-二甲氨基-3-己氧基-4-羟基-1-丁基-2(1H)-喹啉酮(化合物35)7-Dimethylamino-3-hexyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone (compound 35)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，以碘己烷代替碘甲烷，得标题化合物(35)。(产率＝45％)According to the method of example 3, 6 and 15, using 7-nitro-3-acetoxy-4-hydroxy-1-butyl-2(1H)-quinolinone, replacing methyl iodide with iodohexane, the title compound was obtained (35). (Yield = 45%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，4.23(t，2H，J＝7.8Hz)，3.54(m，2H)，3.45(s，6H)，1.97～1.45(m，12H)，0.98(m，6H)11.05(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 4.23(t, 2H, J=7.8Hz), 3.54(m, 2H), 3.45(s, 6H), 1.97～1.45(m, 12H), 0.98(m, 6H)

IR(KBr，cm-1)：3245，1600，1250IR (KBr, cm -1 ): 3245, 1600, 1250

元素分析(C21H32N2O3)Elemental Analysis (C 21 H 32 N 2 O 3 )

理论值(％)：C69.97；H8.95；N7.77；O13.32Theoretical value (%): C69.97; H8.95; N7.77; O13.32

实测值(％)：C69.93；H8.88；N7.66；O13.53Measured value (%): C69.93; H8.88; N7.66; O13.53

实例33Example 33

7-二甲基氨基-3-羟基-4-甲氧基-1-丁基-2(1H)-喹啉酮(化合物36)7-Dimethylamino-3-hydroxy-4-methoxy-1-butyl-2(1H)-quinolinone (compound 36)

按实例2，3和6方法，采用7-硝基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮代替7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(36)。(产率＝47％)According to example 2, 3 and 6 methods, adopt 7-nitro-3-acetoxy-4-hydroxyl-1-butyl-2 (1H)-quinolinone to replace 7-nitro-3-acetoxy- 4-Hydroxy-1-methyl-2(1H)-quinolinone to give the title compound (36). (Yield = 47%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.05(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，4.23(s，3H)，3.54(m，2H)，3.45(s，6H)，1.97～1.45(m，4H)，0.98(d，3H，J＝7.9Hz)11.05(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 4.23(s, 3H), 3.54(m, 2H ), 3.45(s, 6H), 1.97～1.45(m, 4H), 0.98(d, 3H, J=7.9Hz)

IR(KBr，cm-1)：3230，1610，1250IR (KBr, cm -1 ): 3230, 1610, 1250

元素分析(C16H22N2O3)Elemental Analysis (C 16 H 22 N 2 O 3 )

理论值(％)：C66.18；H7.64；N9.65；O16.53Theoretical value (%): C66.18; H7.64; N9.65; O16.53

实测值(％)：C66.19；H7.78；N9.66；O16.37Measured value (%): C66.19; H7.78; N9.66; O16.37

实例34Example 34

7-甲氨基-3-异戊二烯氧基-4-羟基-1-丁基-2(1H)-喹啉酮(化合物37)7-Methylamino-3-prenyloxy-4-hydroxy-1-butyl-2(1H)-quinolinone (compound 37)

按实例26方法，采用7-硝基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，以异戊二烯基溴代替烯丙基溴，得标题化合物(37)。(产率＝57％)According to the method of Example 26, using 7-nitro-3-acetoxy-4-hydroxyl-1-butyl-2(1H)-quinolinone, replacing allyl bromide with prenyl bromide, the title Compound (37). (Yield = 57%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.25(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.，75(m，1H)，5.35(m，1H)，4.56(d，2H，J＝2.0Hz)，3.56(d，2H，J＝7.9Hz)，3.43(s，3H)，1.78～1.23(m，4H)，1.75(s，3H)，1.70(s，3H)，0.97(t，3H，J＝7.9Hz)11.25(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5., 75(m, 1H), 5.35( m, 1H), 4.56(d, 2H, J=2.0Hz), 3.56(d, 2H, J=7.9Hz), 3.43(s, 3H), 1.78～1.23(m, 4H), 1.75(s, 3H ), 1.70(s, 3H), 0.97(t, 3H, J=7.9Hz)

IR(KBr，cm-1)：3245，1605，1250IR (KBr, cm -1 ): 3245, 1605, 1250

元素分析(C19H26N2O3)Elemental Analysis (C 19 H 26 N 2 O 3 )

理论值(％)：C69.06；H7.93；N8.48；O14.53Theoretical value (%): C69.06; H7.93; N8.48; O14.53

实测值(％)：C69.19；H7.98；N8.57；O14.26Measured value (%): C69.19; H7.98; N8.57; O14.26

实例35Example 35

7-甲氨基-3-羟基-4-异戊二烯氧基-1-丁基-2(1H)-喹啉酮(化合物38)7-methylamino-3-hydroxy-4-prenyloxy-1-butyl-2(1H)-quinolinone (compound 38)

按实例2，3和6方法，采用7-硝基-3-乙酰氧基-4-羟基-1-丁基-2(1H)-喹啉酮，用异戊二烯基溴代替碘甲烷作烷基化试剂，得标题化合物(38)。(产率＝47％)According to example 2, 3 and 6 methods, adopt 7-nitro-3-acetoxy group-4-hydroxyl-1-butyl-2(1H)-quinolinone, replace methyl iodide with prenyl bromide as Alkylation reagent, the title compound (38) was obtained. (Yield = 47%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.25(s，1H)，7.89(s，1H)，7.78(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.75(m，1H)，5.35(m，1H)，4.56(d，2H，J＝2.0Hz)，3.56(d，2H，J＝7.9Hz)，3.43(s，3H)，1.78～1.23(m，4H)，1.75(s，3H)，1.70(s，3H)，0.97(t，3H，J＝7.9Hz)10.25(s, 1H), 7.89(s, 1H), 7.78(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.75(m, 1H), 5.35(m, 1H ), 4.56(d, 2H, J=2.0Hz), 3.56(d, 2H, J=7.9Hz), 3.43(s, 3H), 1.78～1.23(m, 4H), 1.75(s, 3H), 1.70 (s, 3H), 0.97 (t, 3H, J=7.9Hz)

IR(KBr，cm-1)：3245，1620，1250IR (KBr, cm -1 ): 3245, 1620, 1250

元素分析(C19H26N2O3)Elemental Analysis (C 19 H 26 N 2 O 3 )

理论值(％)：C69.06；H7.93；N8.48；O14.53Theoretical value (%): C69.06; H7.93; N8.48; O14.53

实测值(％)：C69.21；H7.95；N8.57；O14.27Measured value (%): C69.21; H7.95; N8.57; O14.27

实例36Example 36

7-乙酰氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物39)7-Acetamido-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (compound 39)

在冰浴冷却下，向1.50g7-氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(4.7mmol)的15ml吡啶溶液中加入0.48g乙酸酐(4.7mmol)，搅拌1小时。将混合物倾入水中，用乙酸乙酯提取。有机层用4N-HCl洗涤，减压浓缩。残渣经硅胶层析纯化(己烷/乙酸乙酯＝2/1作洗脱液)得1.03g标题化合物(39)。(产率＝67％)Under cooling in an ice bath, add 0.48 g of acetic anhydride ( 4.7mmol), stirred for 1 hour. The mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with 4N-HCl, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (hexane/ethyl acetate = 2/1 as eluent) to obtain 1.03 g of the title compound (39). (Yield = 67%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.28(s，1H)，10.23(s，1H)，7.85(s，1H)，7.80(d，1H，J＝7.2Hz)，7.40(d，1H，J＝7.2Hz)，3.94(d，2H，J＝7.6Hz)，3.52(s，3H)，2.10(s，3H)，1.71～1.20(m，12H)，0.86(t，3H，J＝7.5Hz)10.28(s, 1H), 10.23(s, 1H), 7.85(s, 1H), 7.80(d, 1H, J=7.2Hz), 7.40(d, 1H, J=7.2Hz), 3.94(d, 2H , J=7.6Hz), 3.52(s, 3H), 2.10(s, 3H), 1.71～1.20(m, 12H), 0.86(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1650，1600，1220IR (KBr, cm -1 ): 3245, 1650, 1600, 1220

元素分析(C20H28N2O4)Elemental Analysis (C 20 H 28 N 2 O 4 )

理论值(％)：C66.64；H7.83；N7.77；O17.76Theoretical value (%): C66.64; H7.83; N7.77; O17.76

实测值(％)：C66.86；H7.88；N7.96；O17.30Measured value (%): C66.86; H7.88; N7.96; O17.30

实例37Example 37

7-(4-乙酰氧基-3，5-二甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物40)7-(4-Acetoxy-3,5-dimethoxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 40)

在冰浴冷却下，向1.50g7-氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(4.7mmol)的15ml吡啶溶液中加入1.33g4-乙酰氧基-3，5-二甲氧基肉桂酰基氯化物(4.7mmol)，搅拌1小时。将混合物倾入水中，乙酸乙酯提取，有机层用4N-HCl洗涤，减压浓缩。残渣经硅胶层析纯化(CH2Cl2/乙酸乙酯＝2/1作洗脱液)得1.70g标题化合物(40)。(产率＝64％)Under cooling in an ice bath, 1.33 g of 4-acetoxy 3,5-dimethoxycinnamoyl chloride (4.7 mmol), stirred for 1 hour. The mixture was poured into water, extracted with ethyl acetate, the organic layer was washed with 4N-HCl, and concentrated under reduced pressure. The residue was purified by silica gel chromatography (CH 2 Cl 2 /ethyl acetate=2/1 as eluent) to obtain 1.70 g of the title compound (40). (Yield = 64%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.50(s，1H)，10.21(s，1H)，7.92(s，1H)，7.85(d，1H，J＝8.8Hz)，7.50(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(s，2H)，6.75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，6H)，3.54(s，3H)，2.25(s，3H)，1.68(m，2H)，1.25(m，10H)，0.86(t，3H，J＝6.8Hz)10.50(s, 1H), 10.21(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.50(d, 1H, J=15.6Hz), 7.49(s, 1H ), 6.93(s, 2H), 6.75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz), 3.82(s, 6H), 3.54(s, 3H), 2.25(s , 3H), 1.68(m, 2H), 1.25(m, 10H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1725，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1725, 1600, 1515, 1250, 1100

元素分析(C31H38N2O8)Elemental Analysis (C 31 H 38 N 2 O 8 )

理论值(％)：C65.71；H6.76；N4.94；O22.59Theoretical value (%): C65.71; H6.76; N4.94; O22.59

实测值(％)：C65.86；H6.68；N4.96；O22.50Measured value (%): C65.86; H6.68; N4.96; O22.50

实例38Example 38

7-(3，5-二甲氧基-4-羟基肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物41)7-(3,5-dimethoxy-4-hydroxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 41)

在冰浴冷却下，向1.20g7-(4-乙酰氧基-3，5-二甲氧基肉桂酰基氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(2.11mmol)的15ml甲醇溶液中加入0.46g甲醇钠(8.4mmol)，搅拌1小时。在加入1.8g大孔树脂后，混合物于室温搅拌1小时，过滤，减压浓缩滤液。残渣用THF和己烷重结晶，得0.79g标题化合物(41)。(产率＝71％)Under cooling in an ice bath, to 1.20 g of 7-(4-acetoxy-3,5-dimethoxycinnamoylamino)-3-octyloxy-4-hydroxyl-1-methyl-2(1H)- Add 0.46 g of sodium methoxide (8.4 mmol) to a solution of quinolinone (2.11 mmol) in 15 ml of methanol, and stir for 1 hour. After adding 1.8 g of macroporous resin, the mixture was stirred at room temperature for 1 hour, filtered, and the filtrate was concentrated under reduced pressure. The residue was recrystallized from THF and hexane to obtain 0.79 g of the title compound (41). (Yield = 71%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.39(s，1H)，10.29(s，1H)，8.92(s，1H)，7.99(s，1H)，7.85(d，1H，J＝8.8Hz)，7.53(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(s，2H)，6.，75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，6H)，3.54(s，3H)，1.68(m，2H)，1.25(m，10H)，0.86(t，3H，J＝6.8Hz)10.39(s, 1H), 10.29(s, 1H), 8.92(s, 1H), 7.99(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.53(d, 1H, J=15.6Hz ), 7.49(s, 1H), 6.93(s, 2H), 6., 75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz), 3.82(s, 6H), 3.54(s, 3H), 1.68(m, 2H), 1.25(m, 10H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1600, 1515, 1250, 1100

元素分析(C29H36N2O7)Elemental Analysis (C 29 H 36 N 2 O 7 )

理论值(％)：C66.39；H6.92；N5.34；O21.35Theoretical value (%): C66.39; H6.92; N5.34; O21.35

实测值(％)：C66.45；H7.08；N4.96；O21.51Measured value (%): C66.45; H7.08; N4.96; O21.51

实例39Example 39

7-(4-乙酰氧基-3，5-二甲氧基肉桂酰氨基)-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物42)7-(4-Acetoxy-3,5-dimethoxycinnamoylamino)-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 42)

按实例37方法，采用7-氨基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮代替7-氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(42)。(产率＝62％)According to the method of example 37, adopt 7-amino-3-hexyloxy-4-hydroxyl-1-methyl-2(1H)-quinolinone instead of 7-amino-3-octyloxyl-4-hydroxyl-1- Methyl-2(1H)-quinolinone to give the title compound (42). (Yield = 62%)

1H-NMR(d6-DMSO，δ-TMS)10.50(s，1H)，10.21(s，1H)，7.92(s，1H)，7.85(d，1H，J＝8.8Hz)，7.50(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(s，2H)，6.75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，6H)，3.54(s，3H)，2.25(s，3H)，1.68(m，2H)，1.25(m，6H)，0.86(t，3H，J＝6.8Hz) 1 H-NMR (d 6 -DMSO, δ-TMS) 10.50(s, 1H), 10.21(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.50(d , 1H, J=15.6Hz), 7.49(s, 1H), 6.93(s, 2H), 6.75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz), 3.82(s , 6H), 3.54(s, 3H), 2.25(s, 3H), 1.68(m, 2H), 1.25(m, 6H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1725，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1725, 1600, 1515, 1250, 1100

元素分析(C30H36N2O7)Elemental analysis (C 30 H 36 N 2 O 7 )

理论值(％)：C64.67；H6.36；N5.20；O23.76Theoretical value (%): C64.67; H6.36; N5.20; O23.76

实测值(％)：C64.85；H6.46；N5.12；O23.57Measured value (%): C64.85; H6.46; N5.12; O23.57

实例40Example 40

7-(4-羟基-3，5-二甲氧肉桂酰氨基)-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物43)7-(4-Hydroxy-3,5-dimethoxycinnamoylamino)-3-hexyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 43)

按实例38方法，用7-(4-乙酰氧基-3，5-二甲氧肉桂酰氨基)-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮代替7-(4-乙酰氧基-3，5-二甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(43)。(产率＝74％)According to the method of example 38, with 7-(4-acetoxy-3,5-dimethoxycinnamoylamino)-3-hexyloxy-4-hydroxyl-1-methyl-2(1H)-quinolinone Substitution of 7-(4-acetoxy-3,5-dimethoxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone afforded the title compound ( 43). (Yield = 74%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.39(s，1H)，10.29(s，1H)，8.92(s，1H)，7.99(s，1H)，7.85(d，1H，J＝8.8Hz)，7.53(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(s，2H)，6.75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，6H)，3.54(s，3H)，1.68(m，2H)，1.25(m，6H)，0.86(t，3H，J＝6.8Hz)10.39(s, 1H), 10.29(s, 1H), 8.92(s, 1H), 7.99(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.53(d, 1H, J=15.6Hz ), 7.49(s, 1H), 6.93(s, 2H), 6.75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz), 3.82(s, 6H), 3.54(s , 3H), 1.68(m, 2H), 1.25(m, 6H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1600, 1515, 1250, 1100

元素分析(C27H32N2O7)Elemental Analysis (C 27 H 32 N 2 O 7 )

理论值(％)：C65.31；H6.50；N5.64；O22.56Theoretical value (%): C65.31; H6.50; N5.64; O22.56

实测值(％)：C65.35；H6.52；N5.59；O22.54Measured value (%): C65.35; H6.52; N5.59; O22.54

实例41Example 41

7-(4-乙酰氧基-3-甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物44)7-(4-Acetoxy-3-methoxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 44)

按实例37方法，用4-乙酰基-3-甲氧肉桂酰氯代替4-乙酰氧基-3，5-二甲氧肉桂酰氯，得标题化合物(44)。(产率＝58％)Following the method of Example 37, substituting 4-acetyl-3-methoxycinnamoyl chloride for 4-acetoxy-3,5-dimethoxycinnamoyl chloride, the title compound (44) was obtained. (Yield = 58%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.50(s，1H)，10.18(s，1H)，7.92(s，1H)，7.85(d，1H，J＝8.8Hz)，7.65(m，2H)，7.50(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(d，1H，J＝8.8Hz)，6.，75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，3H)，3.54(s，3H)，2.21(s，3H)，1.68(m，2H)，1.25(m，10H)，0.86(t，3H，J＝6.8Hz)10.50(s, 1H), 10.18(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.65(m, 2H), 7.50(d, 1H, J=15.6Hz ), 7.49(s, 1H), 6.93(d, 1H, J=8.8Hz), 6., 75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz), 3.82( s, 3H), 3.54(s, 3H), 2.21(s, 3H), 1.68(m, 2H), 1.25(m, 10H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1725，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1725, 1600, 1515, 1250, 1100

元素分析(C30H36N2O7)Elemental analysis (C 30 H 36 N 2 O 7 )

理论值(％)：C67.14；H6.76；N5.22；O20.87Theoretical value (%): C67.14; H6.76; N5.22; O20.87

实测值(％)：C66.96；H6.68；N5.16；O21.20Measured value (%): C66.96; H6.68; N5.16; O21.20

实例42Example 42

7-(4-羟基-3-甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物45)7-(4-Hydroxy-3-methoxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 45)

按实例38方法，用7-(4-乙酰氧基-3-甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮代替7-(4-乙酰氧基-3，5-二甲氧肉桂酰氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮，得标题化合物(45)。(产率＝74％)According to the method of example 38, replace 7-(4-acetoxy-3-methoxycinnamoylamino)-3-octyloxy-4-hydroxyl-1-methyl-2(1H)-quinolinone (4-Acetoxy-3,5-dimethoxycinnamoylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone to give the title compound (45). (Yield = 74%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

10.50(s，1H)，10.10(s，1H)，8.92(s，1H)，7.92(s，1H)，7.85(d，1H，J＝8.8Hz)，7.65(m，2H)，7.50(d，1H，J＝15.6Hz)，7.49(s，1H)，6.93(d，1H，J＝8.8Hz)，6.75(d，1H，J＝15.6Hz)，3.92(t，2H，J＝6.8Hz)，3.82(s，3H)，3.54(s，3H)，1.68(m1，2H)，1.25(m，10H)，0.86(t，3H，J＝6.8Hz)10.50(s, 1H), 10.10(s, 1H), 8.92(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=8.8Hz), 7.65(m, 2H), 7.50(d , 1H, J=15.6Hz), 7.49(s, 1H), 6.93(d, 1H, J=8.8Hz), 6.75(d, 1H, J=15.6Hz), 3.92(t, 2H, J=6.8Hz ), 3.82(s, 3H), 3.54(s, 3H), 1.68(m1, 2H), 1.25(m, 10H), 0.86(t, 3H, J=6.8Hz)

IR(KBr，cm-1)：3550，2940，1600，1515，1250，1100IR (KBr, cm -1 ): 3550, 2940, 1600, 1515, 1250, 1100

元素分析(C28H34N2O6)Elemental Analysis (C 28 H 34 N 2 O 6 )

理论值(％)：C67.99；H6.93；N5.66；O19.41Theoretical value (%): C67.99; H6.93; N5.66; O19.41

实测值(％)：C67.96；H6.78；N5.46；O19.80Measured value (%): C67.96; H6.78; N5.46; O19.80

实例43Example 43

7-(2-丙烯氨基)-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物46)7-(2-propenylamino)-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 46)

按实例3，6和15方法，采用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以烯丙基溴作为氨基的烷基化试剂，得标题化合物(46)。(产率＝37％)Alkylation with allyl bromide as amino group using 7-nitro-3-acetoxy-4-hydroxyl-1-methyl-2(1H)-quinolinone according to the methods of examples 3, 6 and 15 Reagent, the title compound (46) was obtained. (Yield = 37%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.23(s，1H)，7.92(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.92(m，1H)，5.75(m，1H)，5.25(m，2H)，4.58(d，2H，J＝2.0Hz)，4.23(d，2H，J＝7.6Hz)，3.54(s，3H)，1.86～1.45(m，12H)，0.97(t，3H，J＝7.5Hz)11.23(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.92(m, 1H), 5.75(m, 1H ), 5.25(m, 2H), 4.58(d, 2H, J=2.0Hz), 4.23(d, 2H, J=7.6Hz), 3.54(s, 3H), 1.86～1.45(m, 12H), 0.97 (t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3245，1605，1250IR (KBr, cm -1 ): 3245, 1605, 1250

元素分析(C21H30N2O3)Elemental Analysis (C 21 H 30 N 2 O 3 )

理论值(％)：C70.36；H8.44；N7.82；O13.39Theoretical value (%): C70.36; H8.44; N7.82; O13.39

实测值(％)：C70.39；H8.58；N7.96；O13.07Measured value (%): C70.39; H8.58; N7.96; O13.07

实例44Example 44

7-苄氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物47)7-Benzylamino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 47)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以氯苄作氨基的烷基化试剂，得标题化合物(47)。(产率＝45％)According to example 3, 6 and 15 methods, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, use benzyl chloride as the alkylating reagent of amino group, The title compound (47) was obtained. (Yield = 45%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.20(s，1H)，7.92～7.26(m，8H)，5.，73(m，1H)，4.23(d，2H，J＝7.6Hz)，3.85(m，2H)，3.54(s，3H)，1.86～1.45(m，12H)，0.97(t，3H，J＝7.5Hz)11.20(s, 1H), 7.92～7.26(m, 8H), 5., 73(m, 1H), 4.23(d, 2H, J=7.6Hz), 3.85(m, 2H), 3.54(s, 3H ), 1.86～1.45(m, 12H), 0.97(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3235，1610，1250IR (KBr, cm -1 ): 3235, 1610, 1250

元素分析(C25H32N2O3)Elemental Analysis (C 25 H 32 N 2 O 3 )

理论值(％)：C73.49；H7.90；N6.86；O11.75Theoretical value (%): C73.49; H7.90; N6.86; O11.75

实测值(％)：C73.39；H8.08；N6.96；O11.57Measured value (%): C73.39; H8.08; N6.96; O11.57

实例45Example 45

7-异戊二烯氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物48)7-Prenylamino-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 48)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以异戊二烯基溴作氨基基团的烷基化试剂，得标题化合物(48)。(产率＝54％)According to example 3, 6 and 15 methods, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, with isoprenyl bromide as amino group alkylating reagent to give the title compound (48). (Yield = 54%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.23(s，1H)，7.92(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.35(m，1H)，4.23(d，2H，J＝7.6Hz)，3.85(m，3H)，3.54(s，3H)，1.86～1.45(m，12H)，1.75(d，6H，J＝15Hz)，0.97(t，3H，J＝7.5Hz)11.23(s, 1H), 7.92(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.35(m, 1H), 4.23(d, 2H , J=7.6Hz), 3.85(m, 3H), 3.54(s, 3H), 1.86～1.45(m, 12H), 1.75(d, 6H, J=15Hz), 0.97(t, 3H, J=7.5 Hz)

IR(KBr，cm-1)：3235，1600，1230IR (KBr, cm -1 ): 3235, 1600, 1230

元素分析(C23H34N2O3)Elemental Analysis (C 23 H 34 N 2 O 3 )

理论值(％)：C71.47；H8.87；N7.25；O12.42Theoretical value (%): C71.47; H8.87; N7.25; O12.42

实测值(％)：C71.39；H8.78；N7.16；O12.67Measured value (%): C71.39; H8.78; N7.16; O12.67

实例46Example 46

7-苯甲酰氨基-3-辛氧基-4-羟基-1-甲基-2(1H)-喹啉酮(化合物49)7-Benzamido-3-octyloxy-4-hydroxy-1-methyl-2(1H)-quinolinone (Compound 49)

按实例3，6和15方法，使用7-硝基-3-乙酰氧基-4-羟基-1-甲基-2(1H)-喹啉酮，用苯甲酰氯作氨基的烷基化试剂，得标题化合物(49)。(产率＝68％)According to example 3, 6 and 15 methods, use 7-nitro-3-acetoxy group-4-hydroxyl-1-methyl-2(1H)-quinolinone, use benzoyl chloride as the alkylating reagent of amino group , to give the title compound (49). (Yield = 68%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

11.20(s，1H)，9.85(s，1H)，7.83～7.26(m，8H)，4.23(d，2H，J＝7.6Hz)，3.54(s，3H)，1.86～1.45(m，12H)，0.95(t，3H，J＝7.5Hz)11.20(s, 1H), 9.85(s, 1H), 7.83～7.26(m, 8H), 4.23(d, 2H, J=7.6Hz), 3.54(s, 3H), 1.86～1.45(m, 12H) , 0.95(t, 3H, J=7.5Hz)

IR(KBr，cm-1)：3235，1725，1665，1250IR (KBr, cm -1 ): 3235, 1725, 1665, 1250

元素分析(C25H30N2O4)Elemental Analysis (C 25 H 30 N 2 O 4 )

理论值(％)：C71.06；H7.16；N6.63；O15.15Theoretical value (%): C71.06; H7.16; N6.63; O15.15

实测值(％)：C71.13；H7.08；N6.76；O15.03Measured value (%): C71.13; H7.08; N6.76; O15.03

实例47Example 47

7-氨基-3-甲氧基-4-苯甲酰氧基-1-甲基-2(1H)-喹啉酮(化合物50)7-Amino-3-methoxy-4-benzoyloxy-1-methyl-2(1H)-quinolinone (Compound 50)

向1.00g7-硝基-3-甲氧基-4-羟基-1-甲基-2(1H)-喹啉酮(4.00mmol)的7ml吡啶溶液中加入0.675g苯甲酰氯(4.80mmol)，室温搅拌1小时。将混合物倾入45ml2NHcl中，用25ml乙酸乙酯提取。有机层用20ml水洗涤，MgSO4干燥，减压浓缩，生成的7-硝基-3-甲氧基-4-苯甲酰氧基-1-甲基-2(1H)-喹啉酮按实例3方法经还原得0.70g标题化合物(50)。(产率＝56％)0.675 g of benzoyl chloride (4.80 mmol) was added to a solution of 1.00 g of 7-nitro-3-methoxy-4-hydroxy-1-methyl-2(1H)-quinolinone (4.00 mmol) in 7 ml of pyridine, Stir at room temperature for 1 hour. The mixture was poured into 45ml of 2N HCl and extracted with 25ml of ethyl acetate. The organic layer was washed with 20ml of water, dried over MgSO , concentrated under reduced pressure, and the generated 7-nitro-3-methoxy-4-benzoyloxy-1-methyl-2(1H)-quinolinone was The method of Example 3 was reduced to obtain 0.70 g of the title compound (50). (Yield = 56%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.65～7.20(m，6H)，5.85(m，2H)，4.08(s，3H)，3.54(s，3H)7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.65～7.20(m, 6H), 5.85(m, 2H), 4.08(s, 3H), 3.54(s, 3H)

IR(KBr，cm-1)：3245，1725，1600，1250IR (KBr, cm -1 ): 3245, 1725, 1600, 1250

元素分析(C17H16N2O4)Elemental Analysis (C 17 H 16 N 2 O 4 )

理论值(％)：C65.37；H5.16；N8.97；O20.49Theoretical value (%): C65.37; H5.16; N8.97; O20.49

实测值(％)：C65.23；H5.15；N8.78；O20.84Measured value (%): C65.23; H5.15; N8.78; O20.84

实例48Example 48

7-氨基-4-丁氧基-3-己氧基-1-甲基-2(1H)-喹啉酮(化合物51)7-Amino-4-butoxy-3-hexyloxy-1-methyl-2(1H)-quinolinone (compound 51)

按实例2方法，使用7-硝基-3-己氧基-4-羟基-1-甲基-2(1H)-喹啉酮，以碘己烷代替碘甲烷，得7-硝基-4-丁氧基-3-己氧基-1-甲基-2(1H)-喹啉酮。然后按实例3方法，对硝基基团进行还原，得标题化合物(51)。(产率＝57％)According to the method of example 2, use 7-nitro-3-hexyloxy-4-hydroxyl-1-methyl-2(1H)-quinolinone, replace methyl iodide with iodohexane to obtain 7-nitro-4 -butoxy-3-hexyloxy-1-methyl-2(1H)-quinolinone. Then, according to the method of Example 3, the nitro group was reduced to obtain the title compound (51). (Yield = 57%)

1H-NMR(d6-DMSO，δ-TMS) 1 H-NMR (d 6 -DMSO, δ-TMS)

7.90(s，1H)，7.85(d，1H，J＝7.2Hz)，7.50(d，1H，J＝7.2Hz)，5.85(m，2H)，4.25(m，4H)，3.54(s，3H)，1.98～1.45(m，12H)，1.05(m，6H)7.90(s, 1H), 7.85(d, 1H, J=7.2Hz), 7.50(d, 1H, J=7.2Hz), 5.85(m, 2H), 4.25(m, 4H), 3.54(s, 3H ), 1.98～1.45(m, 12H), 1.05(m, 6H)

IR(KBr，cm-1)：3200，1590，1220，1100IR (KBr, cm -1 ): 3200, 1590, 1220, 1100

元素分析(C20H30N2O3)Elemental Analysis (C 20 H 30 N 2 O 3 )

理论值(％)：C69.33；H8.73；N8.09；O13.85Theoretical value (%): C69.33; H8.73; N8.09; O13.85

实测值(％)：C69.18；H8.58；N8.06；O14.18Measured value (%): C69.18; H8.58; N8.06; O14.18

试验实例1Test example 1

小鼠急性毒性试验Acute toxicity test in mice

我们实施此试验的目的是为了确证本发明化合物——氨基喹啉酮衍生物的低毒性。急性毒性试验的方法将在下文中说明。方法：使用食管探子，强行口服给予雄性ICR小鼠(体重为20-25g，每组5只)1000～2000mg/kg剂量的每一种氨基喹啉酮衍生物(化合物6，8-10，14-17，19-51)。给药后，将动物于笼子中关7天，观察一般症状并记录死亡数。致死量(LD50：mg/kg)可以给药后第七天的死亡率外推。The purpose of our implementation of this test is to confirm the low toxicity of the compounds of the present invention—aminoquinolinone derivatives. The method of acute toxicity test will be described below. Methods: Using an esophageal probe, male ICR mice (body weight 20-25g, 5 in each group) were forcibly orally administered 1000-2000 mg/kg of each aminoquinolinone derivative (compounds 6, 8-10, 14 -17, 19-51). After the administration, the animals were kept in cages for 7 days, the general symptoms were observed and the number of deaths was recorded. The lethal dose (LD50: mg/kg) can be extrapolated from the death rate on the seventh day after administration.

结果显示，所有化合物的LD50均超过1000mg/kg，因此，清楚地表明本发明化合物——氨基喹啉酮衍生物具有极其低的毒性。The results showed that the LD50 of all compounds exceeded 1000 mg/kg, therefore, it clearly showed that the compounds of the present invention—aminoquinolinone derivatives had extremely low toxicity.

试验实例2Test example 2

对大鼠体内类似的被动皮肤过敏(PCA)反应的作用Effects on similar passive cutaneous anaphylaxis (PCA) responses in rats

我们借助PCA反应进行药理学实验，该反应是为人们熟知的用于筛选抗过敏剂的反应，以此来证明本发明化合物——氨基喹啉酮衍生物具有抗过敏活性。此实验动物模型是由即发型过敏反应而来，称之为抗原-抗体反应。在下文中，将说明本药理实验的方法。方法：在雄性wistar大鼠(9周令)修剪过的背侧皮肤的两个部位上，经真皮给予0.05ml二硝基苯基化ascaris(DNP-As)的抗血清。 48小时后，以100mg/kg的剂量经口服给予动物悬浮于0.5％甲基纤维素(MC)中的氨基喹啉酮衍生物(受试化合物)。给予受试化合物1小时后，将1ml溶有1mg三硝基苯基化ascaris(TNP-As)和5mg伊文思蓝(Evans Blue)的生理盐水，注射到动物的尾静脉中引起动物过敏。引起过敏30分钟后，用乙醚麻醉动物放血处死，剥下背侧的皮肤。通过测量位于背侧皮肤内表面的兰斑直径(指最短和最长直径)大小来评估染料的泄漏情况。作为赋形剂对照组，仅口服给予0.5％的MC溶液；作为阳性对照，以200mg/kg的剂量，按与受试化合物相同的方法口服给予动物Tranilast的0.5％MC悬浮液。PCA反应的抑制百分率(％)可根据方程式1来计算，结果列于表1。每个实验组由5只大鼠组成。We conducted pharmacological experiments by means of PCA reaction, which is a well-known reaction for screening antiallergic agents, to prove that the compounds of the present invention—aminoquinolinone derivatives have antiallergic activity. This experimental animal model is derived from an immediate hypersensitivity reaction, known as an antigen-antibody reaction. Hereinafter, the method of this pharmacological experiment will be explained. Method: 0.05 ml antiserum of dinitrophenylated ascaris (DNP-As) was administered transdermally on two sites of clipped dorsal skin of male wistar rats (9 weeks old). After 48 hours, the aminoquinolinone derivative (test compound) suspended in 0.5% methylcellulose (MC) was orally administered to the animals at a dose of 100 mg/kg. One hour after administration of the test compound, 1 ml of physiological saline dissolved with 1 mg of trinitrophenylascaris (TNP-As) and 5 mg of Evans Blue was injected into the tail vein of the animals to induce animal allergy. After 30 minutes of hypersensitivity, the animals were anesthetized with ether and sacrificed by bleeding, and the skin on the dorsal side was peeled off. Dye leakage was assessed by measuring the diameter of the blue spots (shortest and longest diameters) located on the inner surface of the dorsal skin. As a vehicle control group, only 0.5% MC solution was orally administered; as a positive control, 0.5% MC suspension of Tranilast was orally administered to animals in the same way as the test compound at a dose of 200 mg/kg. The inhibition percentage (%) of PCA reaction can be calculated according to Equation 1, and the results are listed in Table 1. Each experimental group consisted of 5 rats.

在本实验条件下，如果受试化合物相对于赋形剂对照组对PCA反应抑制超过40％的话，即认为其对即发型过敏反应有明显的效果。Under the conditions of this experiment, if the test compound inhibits the PCA response by more than 40% relative to the vehicle control group, it is considered to have a significant effect on the immediate hypersensitivity reaction.

(方程式1)(Equation 1)

抑制程度(％)＝(A-B)/A×100Inhibition degree (%)=(A-B)/A×100

在方程式1中：In Equation 1:

A：赋形剂对照组的染料泄漏A: Dye leakage from the vehicle control group

B：受试化合物组或阳性对照组的染料泄漏B: Dye leakage from test compound group or positive control group

表1Table 1

化合物序号  抑制程度(％)    化合物序号    抑制程度(％)Compound No. Degree of Inhibition (%) Compound No. Degree of Inhibition (%)

化合物6     46              化合物30      44Compound 6 46 Compound 30 44

化合物8     48              化合物31      46Compound 8 48 Compound 31 46

化合物9     45              化合物32      44Compound 9 45 Compound 32 44

化合物10    42              化合物33      40Compound 10 42 Compound 33 40

化合物14    44              化合物34      40Compound 14 44 Compound 34 40

化合物15    41              化合物35      45Compound 15 41 Compound 35 45

化合物16    42              化合物36      41Compound 16 42 Compound 36 41

化合物17    45              化合物37      42Compound 17 45 Compound 37 42

化合物19    44              化合物38      40Compound 19 44 Compound 38 40

化合物20    41              化合物39      50Compound 20 41 Compound 39 50

化合物21        60        化合物41        53Compound 21 60 Compound 41 53

化合物22        57        化合物43        49Compound 22 57 Compound 43 49

化合物23        44        化合物44        50Compound 23 44 Compound 44 50

化合物24        46        化合物45        41Compound 24 46 Compound 45 41

化合物25        47        化合物46        46Compound 25 47 Compound 46 46

化合物26        41        化合物47        40Compound 26 41 Compound 47 40

化合物27        45        化合物48        50Compound 27 45 Compound 48 50

化合物28        42        化合物49        46Compound 28 42 Compound 49 46

化合物29        42        曲尼司特        54Compound 29 42 Tranilast 54

正如表1所示，氨基喹啉酮衍生物的抑制程度(％)为40-60％，其说明氨基喹啉酮衍生物的抗过敏活性与曲尼司特相当。这些结果清楚地表明本发明化合物氨基喹啉酮衍生物对于即发型哮喘，枯草热以及特异性皮炎为有效用的抗过敏剂。As shown in Table 1, the inhibition degree (%) of aminoquinolinone derivatives is 40-60%, which shows that the antiallergic activity of aminoquinolinone derivatives is equivalent to that of tranilast. These results clearly show that the aminoquinolinone derivatives of the compounds of the present invention are effective antiallergic agents for immediate asthma, hay fever and atopic dermatitis.

试验实例3Test example 3

对小鼠体内由苔基氯引起的接触性皮炎的作用Effects on contact dermatitis induced by orcinyl chloride in mice

借助于人们熟知的实验性接触性皮炎的模型来实施这一药理学试验，从而证明本发明化合物氨基喹啉酮衍生物可以抑制迟发型超敏作用。本实验动物模型为典型的迟发型超敏作用模型，其主要是由细胞免疫反应(免疫学，Vol.15，p.405-416，1968)引发的。迟发型超敏作用可被留体类物质抑制，但已知的抗过敏剂对其没有影响。下文中将说明药理实验的方法。This pharmacological test was carried out with the help of a well-known model of experimental contact dermatitis, thereby demonstrating that the aminoquinolinone derivatives of the compounds of the present invention can inhibit delayed-type hypersensitivity. The experimental animal model is a typical delayed-type hypersensitivity model, which is mainly triggered by cellular immune response (Immunology, Vol. 15, p. 405-416, 1968). Delayed hypersensitivity can be suppressed by steroids but not by known antiallergic agents. The method of pharmacological experiments will be explained below.

方法：对前一天修剪过腹部皮肤的小鼠在其腹部皮肤上用含有7mg苔基氯的0.1ml丙酮进行免疫。免疫7天后。用标度厚度计测量耳朵的厚度，然后在小鼠左耳的两面涂上5ml1％苔基氯的橄榄油溶液，激发免疫应答，激发24小时后，再次测量左耳的厚度。刺激12小时后，强行口服给予20mg/kg剂量的本发明化合物(受试化合物)的0.5％MC悬浮液；作为赋形剂对照组，仅口服给予0.5％MC溶液；作为阳性对照组，口服给予剂量为10mg/kg强的松龙，其为一种留体激素；作为阴性对照物，口服给予剂量为200mg/kg的Trani-last。根据方程式2和3可以计算出对赋形剂对照组厚度增加的抑制程度(％)，结果列于表2。在本实验条件下，如果化合物相对于对照组抑制耳朵肿涨程度超过30％，即认为其对迟发型超敏作用有明显效果。METHODS: Mice whose abdominal skin had been trimmed the previous day were immunized with 0.1 ml of acetone containing 7 mg of orcinyl chloride. 7 days after immunization. Measure the thickness of the ear with a scale thickness meter, then apply 5ml of 1% carcinyl chloride olive oil solution on both sides of the left ear of the mouse to stimulate the immune response, and measure the thickness of the left ear again after 24 hours of stimulation. After 12 hours of stimulation, the 0.5% MC suspension of the compound of the present invention (test compound) was administered orally forcibly at a dose of 20 mg/kg; as a vehicle control group, only 0.5% MC solution was orally administered; as a positive control group, oral administration The dose was 10 mg/kg of prednisolone, a steroid hormone; as a negative control, Trani-last was given orally at a dose of 200 mg/kg. According to Equations 2 and 3, the degree of inhibition (%) on the thickness increase of the vehicle control group can be calculated, and the results are listed in Table 2. Under the experimental conditions, if the compound inhibits ear swelling by more than 30% relative to the control group, it is considered to have a significant effect on delayed hypersensitivity.

(方程式2)(Equation 2)

增加率(％)＝(A-B)/B×100Increase rate (%)=(A-B)/B×100

在方程式2中in equation 2

A：激发24小时后耳朵的厚度A: Ear thickness after 24 hours of excitation

B：激发前耳朵的厚度B: Thickness of ear before excitation

(方程式3)(Equation 3)

抑制率(％)＝(C-D)C×100Inhibition rate (%) = (C-D) C × 100

在方程3中：In equation 3:

C：赋形剂对照组的增加程度(％)C: Degree of increase in vehicle control group (%)

D：受试化合物，阳性对照组的增加程度(％)D: test compound, increase degree of positive control group (%)

表2Table 2

化合物序号  抑制程度(％)   化合物序号    抑制程度(％)Compound No. Degree of Inhibition (%) Compound No. Degree of Inhibition (%)

化合物6      43            化合物31      45Compound 6 43 Compound 31 45

化合物8      41            化合物32      48Compound 8 41 Compound 32 48

化合物9      43            化合物33      40Compound 9 43 Compound 33 40

化合物10     40            化合物34      37Compound 10 40 Compound 34 37

化合物14        38        化合物35        46Compound 14 38 Compound 35 46

化合物15        40        化合物36        40Compound 15 40 Compound 36 40

化合物16        36        化合物37        45Compound 16 36 Compound 37 45

化合物17        43        化合物38        37Compound 17 43 Compound 38 37

化合物19        45        化合物39        48Compound 19 45 Compound 39 48

化合物20        43        化合物41        50Compound 20 43 Compound 41 50

化合物21        51        化合物43        53Compound 21 51 Compound 43 53

化合物22        55        化合物44        53Compound 22 55 Compound 44 53

化合物23        41        化合物45        44Compound 23 41 Compound 45 44

化合物24        44        化合物46        55Compound 24 44 Compound 46 55

化合物25        48        化合物47        48Compound 25 48 Compound 47 48

化合物26        39        化合物48        53Compound 26 39 Compound 48 53

化合物27        46        化合物49        43Compound 27 46 Compound 49 43

化合物28        37        强的松龙        53Compound 28 37 Prednisolone 53

化合物29        48        曲尼司特        6Compound 29 48 Tranilast 6

化合物30        52Compound 30 52

从上表可以观察到，受试化合物对赋形剂对照组而言，可产生40-55％的耳朵肿涨抑制效果。许多氨基喹啉酮衍生物与强的松龙(抑制率为53％)的抑制作用相当。相反，在抗过敏疾病中常用的Tranilast来对迟发型超敏作用产生抑制作用。这些结果清楚地表明本发明化合物，氨基喹啉酮衍生物对于迟发型超敏作用具有极好的抑制活性，因此可以用来作为治疗严重过敏反应的抗过敏剂，例如对迟发型哮喘等症。It can be observed from the above table that the test compound can produce 40-55% inhibition of ear swelling compared to the vehicle control group. Many aminoquinolinone derivatives were as inhibiting as prednisolone (53% inhibition). In contrast, Tranilast is commonly used in anti-allergic diseases to produce an inhibitory effect on delayed-type hypersensitivity. These results clearly show that the compounds of the present invention, aminoquinolinone derivatives have excellent inhibitory activity on delayed hypersensitivity, and therefore can be used as antiallergic agents for the treatment of severe allergic reactions, such as delayed asthma.

试验实例4Test example 4

对荷兰猪的实验性即发型和迟发型哮喘模型的作用Experimental Immediate and Delayed Asthma Models in Guinea Pigs

哮喘是典型的过敏反应，我们以豚鼠的实验性哮喘模型来进行此药理学实验，目的是为了证实本发明化合物21，41和46具有抑制即发型和迟发型哮喘反应的作用。下文中将说明药理学实验的方法。Asthma is a typical allergic reaction. We used the experimental asthma model of guinea pigs to carry out this pharmacological experiment in order to confirm that compounds 21, 41 and 46 of the present invention have the effect of inhibiting immediate and delayed asthmatic reactions. The method of pharmacological experiments will be explained below.

方法：使雄性hartly豚鼠暴露于气溶胶化的卵清蛋白(OVA)(1％生理盐水)中使之致敏，每日8次每次10分钟。气溶胶是由超声雾化器(NE-U12，Omuron公司出品)发生的。最终的致敏一周后，动物吸入5分钟的OVA(2％生理盐水)使之激发免疫应答。这些动物在激发前1和4小时及激发前30分钟，分别用甲双吡丙酮(10mg/kg，i.v.)和甲氧苄二胺(10mg/kg，i.p.)进行预处理。然后在激发后的1分钟，2，4，5，6，7，8和23-24小时，分别用PULMOS-1(由MedicalInterface Project Station公司制造)对神志清醒的动物的空气道阻力进行1分钟的测量。在激发前1小时及激发后3小时，口服给予动物化合物21，41和46(受试化合物)的0.5％甲基纤维素(MC)悬浮液，剂量分别为5，10及20mg/kg。作为阳性对照组，在激发前2小时及16小时，口服给予强的松龙，剂量为10mg/kg。作为赋形剂对照组，仅口服给予0.5％的MC溶液。通过激发后1分钟气道阻力改变百分比以及刺激后4-8小时之间气道阻力百分改变反应曲线的面积分别地将化合物对即发型及迟发型哮喘反应的作用进行评估。Methods: Male hartly guinea pigs were sensitized by exposing them to aerosolized ovalbumin (OVA) (1% saline), 8 times a day for 10 minutes each. The aerosol was generated by an ultrasonic nebulizer (NE-U12, produced by Omuron Corporation). One week after the final sensitization, the animals were challenged with an immune response by inhalation of OVA (2% saline) for 5 minutes. The animals were pretreated with mediprilone (10 mg/kg, i.v.) and trimethoprim (10 mg/kg, i.p.) 1 and 4 hours before challenge and 30 minutes before challenge, respectively. Then, at 1 minute, 2, 4, 5, 6, 7, 8 and 23-24 hours after challenge, the airway resistance of conscious animals was tested with PULMOS-1 (manufactured by Medical Interface Project Station) for 1 minute, respectively. Measurement. One hour before challenge and 3 hours after challenge, animals were orally administered compound 21, 41 and 46 (test compound) in 0.5% methylcellulose (MC) suspension at doses of 5, 10 and 20 mg/kg, respectively. As a positive control group, prednisolone was orally administered at a dose of 10 mg/kg 2 hours and 16 hours before challenge. As a vehicle control group, only 0.5% MC solution was orally administered. Compound effects on immediate and delayed asthmatic responses were assessed separately by the percent change in airway resistance at 1 minute after challenge and the area of the percent change in airway resistance response curve between 4 and 8 hours after challenge.

根据方程式4可以计算出化合物对于即发型和迟发型哮喘反应的抑制率(％)，结果列于表3。每个实验组由8只豚鼠组成。According to Equation 4, the inhibition rate (%) of the compound on immediate and delayed asthmatic responses can be calculated, and the results are listed in Table 3. Each experimental group consisted of 8 guinea pigs.

(方程4)(equation 4)

抑制率(％)＝(A-B)A×100Inhibition rate (%) = (A-B) A × 100

在方程式4中：In Equation 4:

A：赋形剂对照组中的气道阻力变化百分比A: Percent change in airway resistance in the vehicle control group

B：受试化合物或阳性对照组的气道阻力变化百分比B: Percent change in airway resistance for test compound or positive control group

表3table 3

即发型哮喘immediate asthma

                            抑制率(％) Inhibition rate(%)

mg/kg        化合物21    化合物41  化合物46  强的松龙mg/kg Compound 21 Compound 41 Compound 46 Prednisolone

5              20          26        30        -5 20 26 30 -

10             30          31        28        3510 30 31 28 35

20             31          43        33        -20 31 43 33 -

迟发型哮喘delayed onset asthma

                   抑制率(％) Inhibition rate(%)

mg/kg   化合物21  化合物41  化合物46  强的松龙mg/kg Compound 21 Compound 41 Compound 46 Prednisolone

5         23        39        32        -5 23 39 32 -

10        39        54        44        5110 39 54 44 51

20        48        84        53        -20 48 84 53 -

表3结果显示，氨基喹啉酮衍生物具有相当于或优于强的松龙的抗哮喘活性。因此可以证实，在抑制即发型和迟发性哮喘方面，氨基喹啉酮衍生物均具有极高的活性。The results in Table 3 show that the aminoquinolinone derivatives have anti-asthma activity equivalent to or better than prednisolone. Therefore, it can be confirmed that the aminoquinolinone derivatives have extremely high activity in inhibiting both immediate-onset and delayed-onset asthma.

配方实例1Formulation Example 1

(5％粉剂)(5% powder)

本发明化合物  50mgCompound of the present invention 50mg

乳糖          950mgLactose 950mg

              100mg                        100 mg

下文中将说明配制化合物6，7-10及14-17粉剂的方法。将本发明化合物的结晶置于研钵中研磨，与乳糖彻底混合，然后混合物再用研杵研磨，得到化合物6，7-10及14-17的5％粉剂。Methods for formulating powders of compounds 6, 7-10 and 14-17 are described below. The crystals of the compound of the present invention were ground in a mortar, thoroughly mixed with lactose, and then the mixture was ground with a pestle to obtain 5% powders of compounds 6, 7-10 and 14-17.

配方实例2Recipe example 2

(10％粉剂)(10% powder)

本发明化合物     100mgCompound of the present invention 100mg

乳糖             900mgLactose 900mg

                 1000mg                          1000mg

下文中将说明配制化合物19-30粉剂的方法。重复配制实例1的方法，得到化合物19-30的10％粉剂。The method for formulating compound 19-30 powders will be described below. The method for preparing Example 1 was repeated to obtain 10% powder of compound 19-30.

配方实例3Recipe example 3

(10％颗粒剂)(10% Granules)

本发明化合物     300mgCompound of the present invention 300mg

乳糖             2000mgLactose 2000mg

淀粉             670mgStarch 670mg

明胶             30mgGelatin 30mg

                 3000mg                    3000mg

下文中将说明配制化合物31～39颗粒剂的方法，将本发明化合物与等量的淀粉混合并用研钵研磨，此物进一步和乳糖及余下的淀粉混合。另外，将30mg明胶与1ml纯水混合，加热溶解，冷却后，边搅拌，边与1ml乙醇混合得一明胶溶液。然后，将先前制得的混合物与此明胶溶液混合，生成的混合物经捏和，成粒，干燥后，得化合物31～39的颗粒剂。The method for preparing granules of compounds 31-39 will be described below by mixing the compound of the present invention with an equal amount of starch and grinding in a mortar, which is further mixed with lactose and the remaining starch. In addition, mix 30 mg of gelatin with 1 ml of pure water, heat to dissolve, and after cooling, mix with 1 ml of ethanol while stirring to obtain a gelatin solution. Then, the previously prepared mixture was mixed with the gelatin solution, and the resulting mixture was kneaded, granulated, and dried to obtain granules of compounds 31-39.

配方实例4Recipe Example 4

(5mg片剂)(5mg tablet)

本发明化合物     5mgCompound of the present invention 5mg

乳糖             62mgLactose 62mg

淀粉             30mgStarch 30mg

滑石             2mgTalc 2mg

硬脂酸镁         1mgMagnesium stearate 1mg

                 100mg/片                                                             

下文中将说明化合物40-51的制片方法。采用20倍于上述组份的量来制片剂，每片含有5mg活性成分。即将100mg本发明化合物的结晶置于研钵中研磨，与乳糖和淀粉混合。然后该混合物再与10％的淀粉糊混合，混合物经捏和后成粒。干燥后，生成的颗粒与滑石和硬脂酸镁混合，用常规方法压片。采用上述方法，即可获得化合物40-51的片剂。The preparation method of compound 40-51 will be described below. Use 20 times the amount of the above components to make tablets, each containing 5 mg of active ingredient. That is, 100 mg of crystals of the compound of the present invention were ground in a mortar and mixed with lactose and starch. Then the mixture was mixed with 10% starch paste, and the mixture was kneaded and granulated. After drying, the resulting granules are mixed with talc and magnesium stearate and compressed by conventional methods. Using the above method, the tablets of compound 40-51 can be obtained.

配方实例5Formulation Example 5

(20mg片剂)(20mg tablet)

本发明化合物                20mgCompound of the present invention 20mg

6％羟丙基纤维素/乳糖        75mg6% Hydroxypropyl Cellulose/Lactose 75mg

硬脂酸盐/滑石               2mgStearate/talc 2mg

土豆淀粉                    3mgPotato starch 3mg

                            100mg/片                                                  

下文中将说明化合物40-43片剂的制备方法。采用10倍于上述组分量的原料来制备片剂，每片含有20mg活性成分。即将6g羟丙基纤维素溶于适量的乙醇中，与94g乳糠混合，捏和。干燥至一定程度后，混合物过60目筛子，分级得到的颗粒作为6％的羟丙基纤维素/乳糖来使用。另外，将硬脂酸镁及滑石以1∶4的比例混合，作为硬脂酸盐/滑石。然后将本发明化合物，6％羟丙基纤维素/乳糖，硬脂酸盐/滑石和土豆淀粉彻底混合，用常规方法压片。采用上述步骤，可以制得化合物40-43的片剂。The preparation method of the compound 40-43 tablet will be described below. Tablets were prepared with raw materials 10 times the amount of the above components, and each tablet contained 20 mg of the active ingredient. Dissolve 6g of hydroxypropyl cellulose in an appropriate amount of ethanol, mix with 94g of milk bran, and knead. After drying to a certain degree, the mixture was passed through a 60-mesh sieve, and the granules obtained by classification were used as 6% hydroxypropylcellulose/lactose. Separately, magnesium stearate and talc were mixed at a ratio of 1:4 to obtain stearate/talc. The compound of the present invention, 6% hydroxypropylcellulose/lactose, stearate/talc and potato starch are then thoroughly mixed and compressed in a conventional manner. Using the above steps, tablets of compounds 40-43 can be prepared.

配方实例6Formulation example 6

(25mg片剂)(25mg tablet)

本发明化合物         25mgCompound of the present invention 25mg

乳糖                 122mgLactose 122mg

羧甲基淀粉           50mgCarboxymethyl starch 50mg

滑石                 2mgTalc 2mg

硬脂酸镁             1mgMagnesium stearate 1mg

                    200mg/片                                                                                                                                          200 mg/tablet

在下文中将说明化合物21，22及30-32的制片方法。用10倍于上述组分量的原料来制片。每片含有25mg活性成分，即将250mg本发明化合物的结晶在研钵中研磨，并与乳糖彻底混合。将适量的纯水加到羧甲基淀粉中，然后将此物加到前述的混合物中，生成的混合物经捏和再成粒。干燥后，将制得的颗粒与滑石和硬脂酸镁混合，用常规方法压片。采用上述方法，得到化合物21，22及30-32的片剂。The preparation methods of compounds 21, 22 and 30-32 will be described below. Tablets were made with 10 times the amount of raw materials of the above components. Each tablet contains 25 mg of active ingredient, ie 250 mg of crystals of the compound of the invention are ground in a mortar and mixed thoroughly with lactose. An appropriate amount of pure water is added to the carboxymethyl starch, which is then added to the aforementioned mixture, and the resulting mixture is kneaded and then granulated. After drying, the resulting granules are mixed with talc and magnesium stearate and compressed in the usual manner. Using the above method, tablets of compounds 21, 22 and 30-32 were obtained.

配方实例7Formulation Example 7

(10mg胶囊)(10mg capsule)

本发明化合物         300mgCompound of the present invention 300mg

乳糖                 2000mgLactose 2000mg

淀粉                 670mgStarch 670mg

明胶                 30mgGelatin 30mg

                     3000mg                        3000mg

下文中将说明化合物31-39的制片方法。按实例3所述方法制粒，每100mg装入一个胶囊中。采用上述方法，得化合物31-39的胶囊。The preparation method of compound 31-39 will be described below. Granulate according to the method described in example 3, every 100mg is packed in a capsule. Using the above method, the capsules of compounds 31-39 were obtained.

配方实例8Recipe Example 8

(0.5％软膏)(0.5% ointment)

本发明化合物        5mgCompound of the present invention 5mg

液体石蜡            80mgLiquid paraffin 80mg

白凡士林            915mgWhite petrolatum 915mg

                    1000mg                                                                           

下文中将说明化合物21，30和41～44片剂的制备方法。用10倍于上述组分量的原料来制备软膏，每个含有5％的活性成分。即将本发明化合物与少量的液体石蜡充分混合，并在研钵中研磨，作为分散溶液。另外，将白凡士林与液体石蜡经加热混合制成基质。将前述的分散溶液分次加入基质中，彻底捏和至均匀。采用上述方法，可以制得化合物21，30及41～44的软膏。The preparation of the tablets of Compounds 21, 30 and 41-44 will be described below. An ointment was prepared using 10 times the amount of the above-mentioned components of the raw materials, each containing 5% of the active ingredient. That is, the compound of the present invention is thoroughly mixed with a small amount of liquid paraffin, and ground in a mortar, as a dispersion solution. In addition, white petrolatum and liquid paraffin are heated and mixed to form a base. Add the aforementioned dispersion solution to the matrix in portions, and knead thoroughly until uniform. The ointment of compounds 21, 30 and 41-44 can be prepared by the above method.

因此，很显然，这里提供了一种新颖的硝基喹啉酮衍生物，即来自硝基喹啉酮衍生物的氨基喹啉酮衍生物及其生理上可接受的盐类。本发明所提供的氨基喹啉酮衍生物及其生理学上可接受的盐类也是极好的抗过敏剂，其毒性低，并可用于治疗或预防即发型及迟发型过敏性疾病，特别是对那些用先前工艺制得的抗过敏剂无法有效地治疗的延迟型过敏疾病具有极佳的疗效。Accordingly, it is apparent that there is provided a novel nitroquinolinone derivative, namely an aminoquinolinone derivative derived from a nitroquinolinone derivative, and physiologically acceptable salts thereof. The aminoquinolinone derivatives provided by the present invention and their physiologically acceptable salts are also excellent antiallergic agents with low toxicity and can be used for the treatment or prevention of immediate and delayed allergic diseases, especially for Those delayed-type allergic diseases that cannot be effectively treated by the antiallergic agents prepared by the prior art have excellent curative effects.

尽管这里已对本发明作了详尽的描述，并给出了具体的实例，但是很明显，对于本领域内的专业人员来说，在不背离本发明精神和不超出其范围的前提下，可作各种变化和修饰或改良。Although the present invention has been described in detail and specific examples have been given here, it is obvious that those skilled in the art can make Various changes and modifications or improvements.

Claims (4)

  1. The 7-nitroquinoline ketone derivatives of the following general formula of tool (II) with and physiology on acceptable salt,
    Figure C0010642600021
    Wherein
    R 1For hydrogen atom or contain the straight or branched alkyl group of 1-10 carbon atom;
    R 2Be hydrogen atom, contain straight or branched alkyl group, the acyl group of 1-10 carbon atom or contain the straight or branched alkenyl group of 2-10 carbon atom; And
    R 3Be hydrogen atom, contain the straight or branched alkyl group of 1-10 carbon atom or contain the straight or branched alkenyl group of 2-10 carbon atom;
  2. 2. acceptable salt, wherein R on 7-nitroquinoline ketone derivatives in the claim 1 and the physiology thereof 2Be the alkyl group of tool 1-10 carbon atom, or the straight or branched alkenyl group of tool 2-10 carbon atom; And R 3Be hydrogen atom.
  3. 3. acceptable salt, wherein R on 7-nitroquinoline ketone derivatives in the claim 1 and the physiology thereof 2Be carboxyl groups; And R 3Be hydrogen atom, the straight or branched alkyl group of tool 1-10 carbon atom, or the straight or branched alkenyl group of tool 2-10 carbon atom.
  4. 4. the 7-nitroquinoline ketone derivatives with one of claim 1-3 definition is used to prepare 7-quinolylamine ketone derivatives or its pharmaceutical salts, or is used to prepare anti-allergy agent.
CNB001064266A 1996-01-17 1997-01-16 Quinoline ketone derivant and antianaphylaction using same as active substance Expired - Fee Related CN1158265C (en)

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WO2001019368A1 (en) * 1999-09-10 2001-03-22 Dainippon Ink And Chemicals, Inc. Quinolinone derivative preparations and process for producing the same
US6706733B2 (en) 2001-05-08 2004-03-16 Dainippon Ink And Chemicals, Inc. Quinolinone derivative formulation and its production method
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