CN115813878B - Waterproof coating solution and application thereof in preparation of waterproof capsules - Google Patents
Waterproof coating solution and application thereof in preparation of waterproof capsules Download PDFInfo
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- CN115813878B CN115813878B CN202211582642.8A CN202211582642A CN115813878B CN 115813878 B CN115813878 B CN 115813878B CN 202211582642 A CN202211582642 A CN 202211582642A CN 115813878 B CN115813878 B CN 115813878B
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- 239000002775 capsule Substances 0.000 title claims abstract description 129
- 239000011248 coating agent Substances 0.000 title claims abstract description 90
- 238000000576 coating method Methods 0.000 title claims abstract description 90
- 238000002360 preparation method Methods 0.000 title claims description 5
- HPEUJPJOZXNMSJ-UHFFFAOYSA-N Methyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC HPEUJPJOZXNMSJ-UHFFFAOYSA-N 0.000 claims abstract description 48
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims abstract description 48
- 235000013871 bee wax Nutrition 0.000 claims abstract description 32
- 239000012166 beeswax Substances 0.000 claims abstract description 30
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims abstract description 30
- 235000021314 Palmitic acid Nutrition 0.000 claims abstract description 24
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims abstract description 24
- CAMHHLOGFDZBBG-UHFFFAOYSA-N epoxidized methyl oleate Natural products CCCCCCCCC1OC1CCCCCCCC(=O)OC CAMHHLOGFDZBBG-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000000034 method Methods 0.000 claims description 9
- 238000001035 drying Methods 0.000 claims description 7
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000010992 reflux Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 238000003756 stirring Methods 0.000 claims description 3
- 238000007711 solidification Methods 0.000 claims description 2
- 230000008023 solidification Effects 0.000 claims description 2
- 230000007306 turnover Effects 0.000 claims description 2
- 239000003814 drug Substances 0.000 abstract description 20
- 239000007788 liquid Substances 0.000 abstract description 6
- 230000003115 biocidal effect Effects 0.000 abstract description 3
- 230000007547 defect Effects 0.000 abstract description 3
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 2
- 230000002708 enhancing effect Effects 0.000 abstract description 2
- 235000016709 nutrition Nutrition 0.000 abstract description 2
- 230000035764 nutrition Effects 0.000 abstract description 2
- 108010010803 Gelatin Proteins 0.000 description 34
- 229920000159 gelatin Polymers 0.000 description 34
- 239000008273 gelatin Substances 0.000 description 34
- 235000019322 gelatine Nutrition 0.000 description 34
- 235000011852 gelatine desserts Nutrition 0.000 description 34
- 239000000243 solution Substances 0.000 description 24
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 238000012360 testing method Methods 0.000 description 12
- 239000000463 material Substances 0.000 description 11
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 7
- 238000013112 stability test Methods 0.000 description 7
- 230000000052 comparative effect Effects 0.000 description 4
- 150000003626 triacylglycerols Chemical class 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 3
- 239000007766 cera flava Substances 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 3
- 239000002552 dosage form Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 238000011056 performance test Methods 0.000 description 3
- 241001465754 Metazoa Species 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000007903 gelatin capsule Substances 0.000 description 2
- 239000008187 granular material Substances 0.000 description 2
- 230000002209 hydrophobic effect Effects 0.000 description 2
- 238000007689 inspection Methods 0.000 description 2
- YIXJRHPUWRPCBB-UHFFFAOYSA-N magnesium nitrate Chemical compound [Mg+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O YIXJRHPUWRPCBB-UHFFFAOYSA-N 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 241000973497 Siphonognathus argyrophanes Species 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 239000008213 purified water Substances 0.000 description 1
- 239000012047 saturated solution Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000012430 stability testing Methods 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
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Abstract
The invention discloses a waterproof coating solution and application of preparing a waterproof capsule, wherein the waterproof coating solution consists of beeswax, palmitic acid, methyl stearate and n-hexane; the mass ratio of the beeswax to the palmitic acid to the methyl stearate is 1:1:1-5; the volume usage of the n-hexane is 0.5-5ml/g based on the mass of the beeswax; the edible waterproof coating has the characteristics of antibiosis, uneasiness of breakage, innocuity and innocuity, and can play a certain role in antioxidation and bacteriostasis, thereby greatly enhancing the application value of the edible waterproof coating. The invention uses the edible waterproof coating to coat the inner wall of the capsule, is a capsule product capable of containing liquid content, and compared with the traditional hollow capsule without the coating, not only solves the defect that the liquid medicine can not be used in the capsule, but also can increase the intake of beewax and improve the nutrition.
Description
Field of the art
The invention relates to the field of special materials of capsules, in particular to a waterproof coating solution and application thereof in preparation of waterproof capsules.
(II) background art
The waterproof capsule coating is a medicinal coating material, has the characteristics of good waterproof performance, convenient use, good practicability and the like, is simple in manufacturing process, low in cost, edible and easy to degrade, is a medicinal coating material with development potential, and has good development prospect.
Capsules are common pharmaceutical dosage forms. The empty capsules can be classified into animal-derived and plant-derived capsules according to the material, and the most common empty capsules are gelatin empty capsules of animal origin. The gelatin hollow capsule is insoluble in water, but slowly expands and softens when meeting water, and gradually absorbs water 5 to 10 times of the weight of the gelatin hollow capsule, so that the characteristic can ensure good disintegration time of the hollow capsule and achieve the effect of releasing the medicine in vivo. Some traditional Chinese medicine components also adopt gelatin hollow capsules as dosage forms, but moisture in the capsules can migrate into the traditional Chinese medicine components due to the hygroscopicity of the traditional Chinese medicine, so that the water content of the traditional Chinese medicine components is increased, and the capsules can be easily crushed due to water loss, thereby reducing the quality and the shelf life of the whole medicine.
(III) summary of the invention
The invention aims to provide a water-proof coating solution and application of preparing a water-proof capsule, which can be applied to hollow capsules of all sources, overcome the defect that the existing hollow capsules cannot meet the requirement of filling liquid medicine into the capsules, widen the dosage form of the liquid medicine, and improve the quality guarantee period and quality of the medicine easy to absorb moisture.
The technical scheme adopted by the invention is as follows:
The invention provides a waterproof coating solution for the inner wall of a capsule, which is prepared from beeswax, palmitic acid, methyl stearate and n-hexane; the mass ratio of the beeswax to the palmitic acid to the methyl stearate is 1:1:1-5, preferably 1:1:2; the volume amount of n-hexane is 0.5-5ml/g, preferably 1.5ml/g, based on the mass of beeswax.
The waterproof coating solution disclosed by the invention is prepared by the following steps: heating and mixing beeswax, palmitic acid and methyl stearate, and stirring until beeswax, palmitic acid and methyl stearate are completely melted and mixed; and adding n-hexane, refluxing, heating and uniformly mixing to obtain the waterproof coating solution.
Preferably, beeswax, palmitic acid and methyl stearate are heated to 80 ℃ and melt mixed; reflux time after the addition of n-hexane was 30min.
The invention also provides an application of the waterproof coating solution in preparing a waterproof capsule, and the application method comprises the following steps:
And (3) coating the water-proof coating solution in the hollow capsule, standing for solidification, and drying to obtain the capsule with the water-proof coating coated inside.
Preferably, the water-proof coating solution is added into the hollow capsule in a dripping way; the dripping is to open the hollow capsule cap, drip 5-6 drops of waterproof coating solution, buckle the capsule cap, turn over up and down to make the solution uniformly spread on the inner wall of the capsule, stand, wait for the coating to fix and shape; the solution is evenly smeared on the inner wall of the capsule, a capsule cap is buckled, the capsule is stood at room temperature, and the coating is fixed and molded.
Preferably, the drying is to open the coated capsule and dry it at 25 ℃ for 20 minutes.
Beeswax is a common strong hydrophobic substance, is in a solid state at normal temperature, is not easy to move and fall off, and is a main component of the waterproof layer to play a role. The methyl stearate has certain hydrophobicity, and meanwhile, the beeswax can soften and enhance the film forming property of the waterproof coating between the beeswax and the methyl stearate, so that the methyl stearate has certain emulsifier function. The palmitic acid has a certain modeling agent function, so that the beeswax can be better modeled to enhance the stability of the waterproof coating. N-hexane as a solvent allows the beeswax, palmitic acid and methyl stearate to fuse sufficiently, and is volatile and can be removed more easily after coating.
The beeswax and the methyl stearate are food-grade pharmaceutical excipients.
Compared with the prior art, the invention has the beneficial effects that:
The edible waterproof coating has the characteristics of antibiosis, uneasiness of breakage, innocuity and innocuity, and can play a certain role in antioxidation and bacteriostasis, thereby greatly enhancing the application value of the edible waterproof coating.
Compared with the traditional hollow capsule without the coating, the capsule product capable of containing the liquid content not only solves the defect that the liquid medicine cannot be used in the capsule, but also can increase the intake of beewax and improve the nutrition.
(IV) detailed description of the invention
The invention will be further described with reference to the following specific examples, but the scope of the invention is not limited thereto:
example 1 Water-barrier coating Capsule
8G of methyl stearate, 4g of beeswax and 4g of palmitic acid are put into a round-bottom flask, melted and mixed in a water bath kettle at 80 ℃ and stirred uniformly, 6ml of n-hexane is added, heating reflux is carried out for 30 minutes, and stirring is uniform, thus obtaining the edible waterproof coating solution.
Taking 5 gelatin hollow capsules (batch number: 20220210) and 5 enteric gelatin hollow capsules (batch number: 20220211) respectively, opening capsule caps respectively, adding 5-6 drops of water-proof coating solution into each capsule shell while the solution is hot, buckling the capsule caps, rapidly shaking to uniformly coat the solution on the inner wall of the capsule, standing at room temperature, standing until the coating is fixed and formed, opening the coated capsule, and drying for 20 minutes at 25 ℃ to obtain the gelatin hollow capsules (marked as S1) with the inner wall coated with the edible water-proof coating and the enteric gelatin hollow capsules (marked as S2) with the inner wall coated with the edible water-proof coating, wherein the coating thickness is 0.4-0.5mm. The obtained edible waterproof coating has the characteristics of antibiosis, uneasiness of breakage, innocuity and innocuity.
Comparative example 1, coating capsules of different proportions
In the same manner as in example 1, one or more of methyl stearate, beeswax and palmitic acid were mixed in different proportions according to tables 1 and 2, put into a round-bottomed flask, melted and mixed in a water bath at 80 ℃ and stirred uniformly, heated for 30 minutes and stirred uniformly to obtain a coating solution.
Taking 5 capsules of gelatin hollow capsules (batch number: 20220210) and enteric gelatin hollow capsules (batch number: 20220211) respectively, opening capsule caps respectively, adding 5-6 drops of coating solutions with different proportions into each capsule shell while the coating solutions are hot, buckling the capsule caps, rapidly shaking to uniformly smear the solutions on the inner wall of the capsules, standing at room temperature, standing until the coating is fixed and formed, opening the smeared capsules, and drying at 25 ℃ for 20 minutes to obtain the capsules with the different proportions, wherein the numbers are shown in tables 1 and 2.
Table 1 coating capsule numbers (gelatin hollow capsules) in different ratios
| Stearic acid methyl ester | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering device |
| 8g | 0 | 0 | 6ml | A1 |
| 0 | 4g | 0 | 6ml | A2 |
| 0 | 0 | 4g | 6ml | A3 |
| 8g | 4g | 0 | 6ml | A4 |
| 8g | 0 | 4g | 6ml | A5 |
| 0 | 4g | 4g | 6ml | A6 |
| 4g | 4g | 4g | 6ml | A7 |
| 4g | 4g | 8g | 6ml | A8 |
| 4g | 8g | 4g | 6ml | A9 |
| 10g | 1g | 1g | 6ml | A10 |
| 8g | 4g | 4g | 0 | A11 |
Table 2 coating capsule numbers (enteric gelatin hollow capsules) in different ratios
Comparative example 2 capsule coated with different materials
As in example 1, according to tables 3 and 4, triglyceride and ethyl acetate were respectively used instead of methyl stearate, and then mixed with beeswax and palmitic acid, and put into a round bottom flask, and melt-mixed in a water bath at 80 ℃ and stirred uniformly, heated and refluxed for 30 minutes, and stirred uniformly, to obtain a coating solution.
Taking 5 capsules of gelatin hollow capsules (batch number: 20220210) and enteric gelatin hollow capsules (batch number: 20220211) respectively, opening capsule caps respectively, adding 5-6 drops of coating solutions of different materials into each capsule shell while the coating solutions are hot, buckling the capsule caps, rapidly shaking to uniformly coat the solutions on the inner wall of the capsule, standing at room temperature, standing until the coating is fixed and formed, opening the coated capsules, and drying at 25 ℃ for 20 minutes to obtain the coated capsules of different materials, wherein the numbers are shown in tables 3 and 4.
TABLE 3 coating capsule numbers for different materials (gelatin hollow capsules)
| Triglycerides (Triglycerides) | Acetic acid ethyl ester | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering device |
| 8g | 0g | 4g | 4g | 6ml | C1 |
| 0g | 8g | 4g | 4g | 6ml | C2 |
TABLE 4 coating of different materials Capsule numbers (enteric gelatin hollow capsules)
| Triglycerides (Triglycerides) | Acetic acid ethyl ester | Beeswax (Cera flava) | Palmitic acid | N-hexane | Numbering device |
| 8g | 0g | 4g | 4g | 6ml | D1 |
| 0g | 8g | 4g | 4g | 6ml | D2 |
Example 2 coating Performance test
The hollow capsules S1 and S2 with the inner wall coated with the waterproof coating layer prepared in example 1, the capsules A1 to A11 and B1 to B11 with the different coating layers prepared in comparative example 1 and the capsules C1, C2, D1 and D2 with the different coating layers prepared in comparative example 2 are respectively taken to obtain 5 capsules, each capsule is added with 0.5ml of purified water, and the mixture is placed under the room temperature condition, and the properties are shown in tables 5 and 6. As can be seen from tables 5 and 6, the lower the palmitic acid content, the more easily the coating is broken, the higher the palmitic acid content, the more easily the coating is crystallized, resulting in the coating not forming a film, so that a certain amount of palmitic acid can improve the stability of the coating; beeswax is the main film forming material and has strong hydrophobic effect, high hardness and poor plasticity, and is not formed into a film when being singly applied. The lower the methyl stearate content is, the higher the hardness of the coating is, and the softer the coating is, so that the methyl stearate plays a role of a certain emulsifier, the three can be softened and dissolved by the n-hexane, the viscosity of the coating can be improved, the coating is easy to volatilize and remove, and the four raw materials are indispensable.
TABLE 5 coating Performance test results (gelatin hollow capsules)
TABLE 6 coating Performance test results (enteric gelatin hollow capsules)
Example 3 experiments to improve stability of Chinese patent drug capsules
The traditional Chinese medicine capsule shell has the advantages of reduced stability and easy breakage after being placed for a long time due to the strong moisture absorption property of the traditional Chinese medicine components, and the waterproof coating can effectively solve the problem. The stability test of the Chinese patent medicine capsules is carried out on gelatin hollow capsules (batch number: 20220210) and enteric gelatin hollow capsules (batch number: 20220211), and the specific method is as follows:
comparison group: the hollow gelatin capsule (batch number: 20220210) without waterproof coating and the hollow enteric gelatin capsule (batch number: 20220211) are filled with rhizoma Gastrodiae refreshment Chinese medicinal composition.
Test article group: the inner wall-coated edible water-proof coating gelatin hollow capsule (lot number: 20220210) S1 prepared in the method of example 1, and the inner wall-coated edible water-proof coating enteric gelatin hollow capsule (lot number: 20220211) S2 were filled with rhizoma Gastrodiae refreshment Chinese medicinal components.
According to friability inspection method under 2020 "Chinese pharmacopoeia" gelatin hollow capsule item, respectively taking 50 pieces of test article group and comparison group, placing into a surface dish, placing into a drier containing magnesium nitrate saturated solution, placing into a constant temperature of 25+ -1deg.C for 24 hr, taking out, immediately respectively placing into glass tube (inner diameter is 24mm, length is 200 mm) standing on wood plate (thickness is 2 cm), and freely falling from glass tube mouth according to cylindrical code (material is polytetrafluoroethylene, diameter is 22mm, weight is 20 g+ -0.1 g). The results are shown in tables 7 and 8, and the waterproof coating can effectively reduce the friability of the capsules caused by moisture absorption of the Chinese patent medicine and improve the stability of the Chinese patent medicine capsules.
Table 7 results of stability test of Chinese patent drug capsules (gelatin hollow capsules)
| Time (month) | 1 | 2 | 3 | 4 | 6 |
| Comparison group friable number (granule) | 0 | 1 | 5 | 12 | 19 |
| The number of friable pieces (particles) of the test sample group (S1) | 0 | 0 | 0 | 3 | 3 |
Table 8 results of stability test of Chinese patent drug capsules (enteric gelatin hollow capsules)
| Time (month) | 1 | 2 | 3 | 4 | 6 |
| Comparison group friable number (granule) | 0 | 0 | 0 | 4 | 7 |
| The number of friable pieces (particles) of the test sample group (S2) | 0 | 0 | 0 | 0 | 1 |
Example 4 disintegration experiments of capsules
The disintegration time test was carried out on gelatin hollow capsules (lot number: 20220210) and enteric gelatin hollow capsules (lot number: 20220211) as follows:
Comparison group: gelatin empty capsules without added water barrier coating (lot number: 20220210), enteric gelatin empty capsules (lot number: 20220211).
Test article group: the inner wall-coated edible water-barrier coated gelatin hollow capsule (lot number: 20220210) prepared by the method of example 1 was designated as S1, and the inner wall-coated edible water-barrier coated enteric gelatin hollow capsule (lot number: 20220211) was designated as S2.
The test is carried out according to the disintegration time limit inspection method of the four-part general rule 0921 in the year 2020 of Chinese pharmacopoeia. And 6 grains of the test sample are taken and respectively placed in glass tubes of a lifting type disintegrating instrument hanging basket, and the disintegrating instrument is started to check simultaneously for the test sample group and the comparison group. The results of the disintegration time measurement are shown in Table 9.
Table 9 disintegration time measurement results
The comparison group and the test sample group of the two kinds of empty capsules are disintegrated within the specified range, and meet the quality standard limit specification in pharmacopoeia, the disintegration time limits of the comparison group and the test sample group of the two kinds of empty capsules are not obviously different, and the empty capsules with the water-proof coating added on the inner wall surface have good disintegrability.
Example 5 accelerated stability testing
An accelerated stability test was conducted on a gelatin hollow capsule (lot number: 20220210) S1 coated with an edible water-barrier coating on the inner wall and an enteric gelatin hollow capsule (lot number: 20220211) S2 coated with an edible water-barrier coating on the inner wall, which were prepared by the method of example 1.
Referring to acceleration stability test conditions specified in the general rule 9001 of four portions of the edition of Chinese pharmacopoeia 2020 and the stability test guiding principle of the preparation, as the main raw material of the waterproof coating is a low-melting-point substance, the capsule medicine coated with the waterproof coating is sensitive to temperature, a refrigerator (5 ℃ +/-3 ℃) is needed, and the acceleration test of the pharmaceutical preparation can be carried out under the conditions of the temperature of 25 ℃ +/-2 ℃ and the relative humidity of 60% +/-5%.
30 Particles of each of S1 and S2 coated with a water-proof coating were taken, and 0.5ml of pure water was contained in a capsule, and the capsule was left to stand under conditions of a temperature of 25.+ -. 2 ℃ and a relative humidity of 60.+ -. 5%. Taking out 10 capsules at the time points of 0, 3 and 6 months respectively, and checking and measuring properties, content moisture quality change and disintegration time limit according to the quality standard of four gelatin hollow capsules in the 2020 edition of Chinese pharmacopoeia, wherein the results are shown in Table 10.
Table 10 accelerated stability test results
The results show that after the water-proof coating-coated capsule is placed in water, the properties, the water quality and the disintegration time limit are not obviously changed, which indicates that the acceleration stability is good.
The foregoing is merely a preferred embodiment of the invention, and it is to be understood that the invention is not limited to the form disclosed herein but is not to be construed as excluding other embodiments, but is capable of numerous other combinations, modifications and environments and is capable of modifications within the scope of the inventive concept, either as taught or as a matter of routine skill or knowledge in the relevant art. And that modifications and variations which do not depart from the spirit and scope of the invention are intended to be within the scope of the appended claims.
Claims (7)
1. A water-proof coating solution for the inner wall of a capsule, characterized in that the water-proof coating solution is prepared from beeswax, palmitic acid, methyl stearate and n-hexane; the mass ratio of the beeswax to the palmitic acid to the methyl stearate is 1:1:1-5; the volume usage of the n-hexane is 0.5-5ml/g based on the mass of the beeswax;
The waterproof coating solution is prepared according to the following method: heating and mixing beeswax, palmitic acid and methyl stearate, and stirring until beeswax, palmitic acid and methyl stearate are completely melted and mixed; and adding n-hexane, refluxing, heating and uniformly mixing to obtain the waterproof coating solution.
2. The water-barrier coating solution of claim 1, wherein the mass ratio of beeswax, palmitic acid and methyl stearate is 1:1:2; the volume amount of the n-hexane is 1.5ml/g based on the mass of the beeswax.
3. The water-barrier coating solution of claim 1, wherein the beeswax, palmitic acid and methyl stearate are melt mixed by heating to 80 ℃.
4. The water-barrier coating solution of claim 1, wherein the reflux time after the addition of n-hexane is 30 minutes.
5. Use of the water-barrier coating solution of claim 1 for the preparation of water-barrier capsules, characterized in that the method of use is: and (3) coating the water-proof coating solution in the hollow capsule, standing for solidification, and drying to obtain the capsule with the water-proof coating coated inside.
6. The use according to claim 5, wherein the water-barrier coating solution is added dropwise to the hollow capsule; the dripping is to open the hollow capsule cap, drip 5-6 drops of waterproof coating solution, buckle the capsule cap, turn over up and down to make the solution uniformly spread on the inner wall of the capsule, stand, wait for the coating to fix and shape; the solution is evenly smeared on the inner wall of the capsule, a capsule cap is buckled, the capsule is stood at room temperature, and the coating is fixed and molded.
7. The use according to claim 6, wherein the drying is to open the coated capsule and to dry it at 25 ℃ for 20 minutes.
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| CN101045062A (en) * | 2007-02-04 | 2007-10-03 | 杨喜鸿 | Polyenephophatidylcholine enteric coated preparation, its preparing method and application |
| CN108633256A (en) * | 2017-01-17 | 2018-10-09 | 森下仁丹株式会社 | Manufacturing method containing capsule with diuresis promoting function and containing capsule with diuresis promoting function |
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