CN115813816A

CN115813816A - Mild gel mask and application thereof

Info

Publication number: CN115813816A
Application number: CN202211130779.XA
Authority: CN
Inventors: 吴德群; 李永勇; 任天斌
Original assignee: Jiangsu Jicui Functional Material Research Institute Co ltd
Current assignee: Jiangsu Jicui Functional Material Research Institute Co ltd
Priority date: 2022-09-16
Filing date: 2022-09-16
Publication date: 2023-03-21
Anticipated expiration: 2042-09-16
Also published as: CN115813816B

Abstract

The invention discloses a mild gel mask which comprises a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, wherein the natural polysaccharide aqueous solution comprises natural polysaccharide, active ingredients and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, a penetration enhancer and water. According to the mild gel mask, the gel mask is prepared on the basis of the natural polysaccharide and the ionic cross-linking agent, the gel mask is safe and reliable, and compared with the traditional non-woven fabric mask, the gel material has better skin-friendly property and fitting property and excellent water retention property, and the defect that the traditional mask cannot lock essence substances is overcome.

Description

Mild gel mask and application thereof

Technical Field

The invention relates to a mild gel mask, a preparation method and application thereof, relates to A61K, and particularly relates to the field of cosmetics.

Background

The gel mask is a mask using gel as a substrate, contains moisture and nutrient components, has good skin-attaching property to the face, overcomes the problems of high requirement on the face shape, strong rough texture of mask cloth and weak nutrient component bearing capacity of the traditional mask, and is more and more concerned by people because the gel mask has good skin feel and good tightness with the skin.

The Chinese invention patent CN202011336101.8 discloses a placenta cotyledon hydrogel facial mask and a preparation method thereof, wherein placenta cotyledons of healthy animals are separated and fused with a polyvinyl alcohol hydrogel solution to prepare copolymer hydrogel, and the prepared facial mask has multiple skin care effects of nourishing skin, moisturizing and delaying skin aging, but has higher cost and is not suitable for large-scale production. Chinese invention patent CN202111679165.2 discloses a hydrogel facial mask using vinasse melanoidin and poplar bud total flavonoids as main raw materials and a preparation method thereof, natural, green and harmless biopolymer matrix raw materials with good biocompatibility and skin affinity are adopted to ensure that the matrix of the facial mask is not allergic, and the prepared facial mask has the characteristics of good fitting property, good moisturizing and whitening effects, good peeling integrity and the like, but a stabilizing agent EDTA needs to be introduced, and excessive addition of EDTA can generate side effects, cause certain irritation to skin and cause some skin problems.

Disclosure of Invention

In order to improve the expression of the efficacy of the gel mask and simultaneously reduce the irritation of the penetration enhancer, the invention provides a mild gel mask, which is prepared from a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, wherein the natural polysaccharide aqueous solution comprises a natural polysaccharide, an active ingredient and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, the penetration enhancer and water.

As a preferred embodiment, the mild gel mask is prepared by the following method:

(1) Adding natural polysaccharide and active ingredients into deionized water simultaneously or in batches, and stirring until the natural polysaccharide and the active ingredients are completely dissolved to obtain a natural polysaccharide aqueous solution (the simultaneous addition refers to adding the natural polysaccharide and the active ingredients into the deionized water simultaneously and stirring for dissolving, and the batch addition refers to adding the natural polysaccharide into the deionized water firstly and stirring for dissolving, and then adding the active ingredients and stirring for dissolving);

(2) Adding the ionic crosslinking agent and the penetration enhancer into deionized water simultaneously or in batches, and stirring until the ionic crosslinking agent and the penetration enhancer are completely dissolved to obtain an ionic crosslinking aqueous solution (the simultaneous addition refers to adding the ionic crosslinking agent and the penetration enhancer into the deionized water simultaneously and stirring for dissolving;

(3) Firstly, coating a natural polysaccharide aqueous solution on the surface of skin, then spraying an ion cross-linking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask.

As a preferred embodiment, the natural polysaccharide is selected from one or more of sodium alginate, potassium alginate and lithium alginate.

As a preferred embodiment, the ionic crosslinking agent is selected from one or more of calcium gluconate, strontium gluconate, calcium chloride, lithium chloride, magnesium chloride, strontium chloride, and calcium sulfate.

As a preferred embodiment, the natural polysaccharide is sodium alginate, and the ionic cross-linking agent is calcium gluconate.

As a preferred embodiment, the mass ratio of the natural polysaccharide to water is (1-6): 100, the mass ratio of the ionic crosslinking agent to the water is (0.5-3.5): 100..

In a preferred embodiment, the mass concentration of the active ingredient in the aqueous solution of the natural polysaccharide is 0.001-5%, and the mass concentration of the penetration enhancer in the aqueous solution of the ionic crosslinking is 0.5-10%.

The applicant finds that the active ingredients and the penetration enhancer in the facial mask are added respectively, and the active ingredients in the facial mask can be absorbed by the facial mask when the facial mask is used and mixed, and the irritation of the penetration enhancer in the facial mask to skin is reduced, so that the skin damage can be reduced, and the facial mask is more suitable for sensitive skin. The reason may be because: the penetration enhancer is added in the application, and can interact with the lipid of the stratum corneum on the surface of the skin to change the arrangement structure of the stratum, so that the active ingredients can smoothly penetrate through each layer of the skin and are conveyed to a target part of action to be released at proper concentration, and the skin-care composition has proper slow release rate and slow release amount. However, the applicant finds that the penetration enhancer can also dissolve lipid compounds on the surface of the skin to cause cell shedding, and has certain irritation to sensitive skin with barrier damage, so that the active ingredients and the penetration enhancer are respectively added into the natural polysaccharide aqueous solution and the ionic crosslinking aqueous solution in the application, the direct contact of the penetration enhancer and the skin is avoided, the contact time of the penetration enhancer and the skin is shortened, and in the use process, the natural polysaccharide aqueous solution is firstly coated on the surface of the skin, and then the ionic crosslinking aqueous solution containing the penetration enhancer is sprayed, so that the penetration enhancer can slowly penetrate the surface of the skin, the concentration of the penetration enhancer in contact with the skin is effectively reduced, the irritation of the penetration enhancer to the skin can be obviously inhibited, and the skin-moistening skin-protecting skin-activating agent is more suitable for the sensitive skin. In addition, as the active ingredients are easily affected by external conditions and are inactivated, the separate addition of the active ingredient penetration enhancer is also beneficial to ensuring the activity of the active substances and improving the stability.

As a preferred embodiment, the mass ratio of the natural polysaccharide to water in the natural polysaccharide aqueous solution is (2-6): 100, the mass ratio of the ionic crosslinking agent to the water in the ionic crosslinking aqueous solution is (1-2): 100.

as a preferred embodiment, the volume ratio of the aqueous solution of natural polysaccharide to the aqueous solution of ionic crosslinking is 1: (0.2-2).

As a preferred embodiment, the volume ratio of the aqueous solution of the natural polysaccharide to the aqueous solution of the ionic crosslinking is 1: (0.5-1).

As a preferred embodiment, the active ingredient is selected from one or more of a polypeptide component, a collagen component, a plant extract component, and a polysaccharide component.

As a preferred embodiment, the polypeptide component is selected from one or more of acetyl hexapeptide-8, palmitoyl tripeptide-1, myristoyl pentapeptide-4, palmitoyl tetrapeptide-7.

In a preferred embodiment, the polypeptide component is present in the aqueous solution of the natural polysaccharide in a mass concentration of 0.001 to 0.02%.

As a preferred embodiment, the collagen-like component is selected from one or more of soluble collagen, hydrolyzed collagen, and collagen protein.

In a preferred embodiment, the collagen-based component is present in the aqueous solution of the natural polysaccharide in a mass concentration of 0.5 to 5%.

As a preferred embodiment, the plant extract component is selected from one or more of ginseng extract, kava extract, ganoderma lucidum extract and rose extract.

As a preferred embodiment, the mass concentration of the plant extract component in the natural polysaccharide aqueous solution is 0.1-5%.

As a preferred embodiment, the polysaccharide component is selected from one or more of rhamnose, mannan, β -glucan, dendrobe polysaccharide, ginseng polysaccharide, oat polysaccharide, tremella polysaccharide, konjac glucomannan, chitosan, galactose and agarose.

In a preferred embodiment, the polysaccharide component is present in an aqueous solution of a natural polysaccharide in a mass concentration of 0.1 to 2%.

As a preferred embodiment, the penetration enhancer is selected from one or more of ethanol, carbitol, azone, hydroxyethyl piperazine ethane sulfonic acid in combination.

In a preferred embodiment, the concentration of ethanol in the ionic crosslinking aqueous solution is 1 to 10% by mass.

As a preferred embodiment, the mass concentration of the carbitol in the ionic crosslinking aqueous solution is 1-10%.

In a preferred embodiment, the mass concentration of the azone in the ionic crosslinking aqueous solution is 1 to 2%.

In a preferred embodiment, the mass concentration of the hydroxyethylpiperazine ethanesulfonic acid in the ionic crosslinking aqueous solution is 0.5 to 2%.

The second aspect of the invention provides application of a mild gel mask, which is applied to mask products with anti-aging, whitening, acne removing, soothing and moisturizing effects.

Compared with the prior art, the invention has the following beneficial effects:

(1) According to the mild gel mask, the gel mask is prepared on the basis of the natural polysaccharide and the ionic cross-linking agent, the gel mask is safe and reliable, and compared with the traditional non-woven fabric mask, the gel material has better skin-friendly property and fitting property and excellent water retention property, and the defect that the traditional mask cannot lock essence substances is overcome.

(2) According to the mild gel mask, active substances are added into a natural polysaccharide aqueous solution, a penetration enhancer is added into an ionic crosslinking aqueous solution, the natural polysaccharide aqueous solution is firstly coated on the surface of the skin, then the ionic crosslinking aqueous solution is sprayed on the surface of the skin to form a gel film, the penetration enhancer is prevented from being directly contacted with the skin, the contact time of the penetration enhancer and the skin is shortened, and the natural polysaccharide aqueous solution is firstly coated on the surface of the skin and then the ionic crosslinking aqueous solution containing the penetration enhancer is sprayed.

(3) For a common non-woven fabric facial mask or a traditional gel facial mask, the facial mask can not be completely matched with the facial shapes of different consumers generally, the method adopts a mode of firstly coating, then spraying and then forming, natural polysaccharide aqueous solution is coated to a corresponding position according to requirements, then ionic crosslinking aqueous solution is sprayed on the natural polysaccharide aqueous solution, a rapid crosslinking effect is generated under the action of ions, and finally the gel facial mask is formed. The mask is flexible and convenient to use, controllable in spraying range and shape and capable of meeting various requirements.

(4) The gel matrix natural polysaccharide aqueous solution and the ionic crosslinking aqueous solution adopt the following formula: (0.2-2), the obtained liquid mixture can be quickly crosslinked to form a film on the surface of the skin, and the formed gel mask has large carrying capacity and strong toughness and can realize the carrying of various active ingredients.

(5) The gel mask disclosed by the invention has a proper active ingredient carrying amount, and after gel film forming, the carried active ingredient has proper slow release time and higher slow release amount, the active substance is added into a natural polysaccharide aqueous solution, and the penetration enhancer is added into an ionic cross-linking agent aqueous solution, so that the addition mode avoids damage to a skin barrier possibly caused by some penetration enhancers to the maximum extent. On one hand, the time of direct contact between the penetration enhancer and the skin is reduced, and on the other hand, the natural polysaccharide aqueous solution has direct and effective protection effect on the skin before the penetration enhancer contacts the skin.

(6) The gel mask disclosed by the invention has a good moisturizing effect, can not suck skin moisture backwards after being applied for a long time like a traditional cloth-attached mask, can be used as an instant mask with short application time or a sleep mask with long application time, can also determine the specific application time according to the actual requirements of a user, is flexible in use, and can meet different requirements of the user.

Detailed Description

Example 1

The preparation raw materials of the mild gel mask comprise a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, and the preparation raw materials comprise the following components in parts by weight: natural polysaccharide aqueous solution: 2 parts of sodium alginate, 1 part of rhamnose and 100 parts of deionized water as active ingredients; ionic crosslinking aqueous solution: the ionic crosslinking agent is 1 part of calcium gluconate, the penetration enhancer is 1.5 parts of azone and the deionized water is 100 parts.

The mild gel mask is prepared by adopting the following method:

(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring at 800rmp for 2 hr for dissolving, adding active ingredient, and stirring at 500rmp for 20min to obtain natural polysaccharide water solution;

(2) Preparing an ionic crosslinking aqueous solution: adding an ionic crosslinking agent into deionized water, stirring at 800rmp for 2h for dissolution, adding a penetration enhancer, and stirring at 500rmp for 20min to obtain an ionic crosslinking aqueous solution;

(3) According to the volume ratio of 1:1, firstly coating a natural polysaccharide aqueous solution on the surface of skin, then spraying an ion cross-linking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask. Applying on skin surface for 30min, and taking off the whole piece.

Example 2

The specific preparation method of the mild gel mask is the same as that of example 1, and the differences are that the gel mask comprises the following components in parts by weight: natural polysaccharide aqueous solution: 1 part of lithium alginate as natural polysaccharide, 1 part of rhamnose as active ingredient and 100 parts of deionized water; ionic crosslinking aqueous solution: 1 part of calcium chloride as an ionic crosslinking agent, 1.5 parts of azone as a penetration enhancer and 100 parts of deionized water.

Example 3

The specific preparation method of the mild gel mask is the same as that of example 1, and the differences are that the gel mask comprises the following components in parts by weight: natural polysaccharide aqueous solution: the natural polysaccharide is 5 parts of sodium alginate, the active ingredients are 1 part of rhamnose and 100 parts of deionized water; ionic crosslinking aqueous solution: 3 parts of calcium gluconate serving as an ionic crosslinking agent, 1.5 parts of azone serving as a penetration enhancer and 100 parts of deionized water.

Example 4

The mild gel mask preparation raw materials comprise a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, and the weight parts are as follows: natural polysaccharide aqueous solution: the natural polysaccharide is 3 parts of sodium alginate, the active ingredients are 1 part of rhamnose and 100 parts of deionized water; ionic crosslinking aqueous solution: 2 parts of calcium gluconate serving as an ionic crosslinking agent, 1.5 parts of azone serving as a penetration enhancer and 100 parts of deionized water.

The mild gel mask is prepared by adopting the following method:

(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring at 700rmp for 2 hr for dissolving, adding active ingredient, and stirring at 500rmp for 20min to obtain natural polysaccharide water solution;

(2) Preparing an ionic crosslinking aqueous solution: adding an ionic crosslinking agent into deionized water, stirring for 2h at 700rmp for dissolution, adding a penetration enhancer, and stirring for 20min at 500rmp to obtain an ionic crosslinking aqueous solution;

(3) According to the volume ratio of 1: and 0.5, coating the natural polysaccharide aqueous solution on the surface of the skin, spraying the ion cross-linking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask. Applying on skin surface for 30min, and taking off the whole piece.

Example 5

A mild gel mask, substantially the same as example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:0.1.

example 6

A mild gel mask, substantially the same as example 4, except that: the dosage of the ionic crosslinking agent calcium gluconate in the ionic crosslinking aqueous solution is 0.5 part.

Example 7

A mild gel mask, substantially the same as example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:1.

example 8

A mild gel mask, substantially the same as example 4, except that: the volume ratio of the natural polysaccharide aqueous solution to the ionic crosslinking aqueous solution used in the step (3) is 1:2.

comparative example 1

A mild gel mask, substantially the same as example 4, except that: the amount of the natural polysaccharide sodium alginate in the natural polysaccharide aqueous solution is 7 parts.

Comparative example 2

A mild gel mask, substantially the same as example 3, except that: the weight portion of the material is as follows: the dosage of the ionic crosslinking agent calcium gluconate in the ionic crosslinking aqueous solution is 4 parts.

Comparative example 3

A mild gel mask, substantially the same as example 2, except that: the dosage of the ionic crosslinking agent calcium chloride in the ionic crosslinking aqueous solution is 0.5 part.

Comparative example 4

The gel mask comprises the preparation raw materials of a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, and comprises the following components in parts by weight: natural polysaccharide aqueous solution: 2 parts of sodium alginate as natural polysaccharide, 1 part of rhamnose as an active ingredient, 1.5 parts of azone as a penetration enhancer and 100 parts of deionized water; ionic crosslinking aqueous solution: the ionic cross-linking agent is 1 part of calcium gluconate and 100 parts of deionized water.

The mild gel mask is prepared by adopting the following method:

(1) Preparing a natural polysaccharide aqueous solution: adding natural polysaccharide into deionized water, stirring at 800rmp for 2h for dissolving, adding active ingredient and penetration enhancer, stirring at 500rmp for 20min to obtain natural polysaccharide water solution loaded with active ingredient and penetration enhancer;

(2) Preparing an ionic crosslinking aqueous solution: adding an ionic crosslinking agent into deionized water, stirring at 800rmp for 2h for dissolution, and stirring at 500rmp for 20min to obtain an ionic crosslinking aqueous solution;

(3) According to the volume ratio of 1:1, firstly coating a natural polysaccharide aqueous solution loaded with active ingredients and penetration enhancers on the surface of skin, then spraying an ion cross-linking aqueous solution on the surface of a coating formed by the natural polysaccharide aqueous solution, and forming a film to obtain the gel mask. Applying on skin surface for 30min, and taking off the whole piece.

Comparative example 5

The specific preparation raw materials of the mild gel mask are the same as those in example 1, but the mild gel mask is prepared by the following method:

(3) Mixing a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution in a ratio of 1:1, and injecting the mixture into a mold for shaping to obtain the gel mask. Applying on skin surface for 30min, and taking off the whole piece.

Performance testing

In comparative example 3, after the aqueous solution of the natural polysaccharide was applied to the skin surface and the aqueous solution of the ionic crosslinking agent was sprayed, the complete membrane structure could not be formed for a long time, and the formed membrane could not be completely torn off, which is probably because the ionic crosslinking reaction occurred less and was insufficient to form the complete membrane structure in the case where both the concentration of the natural polysaccharide in the aqueous solution of the natural polysaccharide and the concentration of the ionic crosslinking agent in the aqueous solution of the ionic crosslinking agent were low, and therefore, the performance test was not performed subsequently with respect to the formulation of comparative example 3.

1. Testing the performance of the mask:

the base films prepared in examples 1 to 8, comparative examples 1 to 2, and comparative examples 4 to 5 were subjected to a performance test using the following test methods.

1. Moisture retention property: referring to a test method of QB/T4256-2011 'guidelines for evaluating moisturizing effects of cosmetics', trial experiments were performed on examples 1-8 and comparative examples 1-2,4-5 using a capacitance-method skin moisture tester, and 20 volunteers between 20 and 45 years old were selected for each group. The skin moisture test was performed before using the mask. The hydrogel mask was then applied to the cheeks in the correct manner and 30 minutes after application the moisture content of the skin was measured in the same area on both the left and right sides (3 areas per volunteer, averaged). The average of the measured values is shown in Table 1.

2. Physical cooling performance: for examples and comparative examples, trial experiments were carried out for examples 1-8 and comparative examples 1-2,4-5, each group selecting 10 volunteers between 20-45 years of age. The hydrogel mask was uniformly applied on the left cheek half, and the physical cooling performance of the hydrogel mask after 30min of application was measured using the left and right cheeks as controls during the wet application (3 areas were taken per volunteer, and the average value was taken). The average of the measured values is shown in Table 1.

3. The fitting performance is as follows: for the examples and comparative examples, trial experiments were carried out on examples 1-8 and comparative examples 1-2,4-5, each group selecting 20 volunteers between the ages of 20-45. The facial mask is applied for 30min, the volunteers keep normal sitting and simple activities in the facial mask application process, the highest positions of the facial mask when the application is started and finished are respectively recorded, the difference value of the highest positions and the highest position is the dropping distance (each volunteer tests for 3 times and takes the average value), and the test results are shown in table 1.

4. And (3) gelling time: hydrogel masks were prepared separately by the methods provided in examples and comparative examples, skin tests were performed after the preparation was completed, the gel-forming time of the hydrogel was observed (3 times per volunteer, and an average value was taken), and the results are reported in table 2.

5. Mechanical properties: after vaseline was uniformly applied to the surface of the obtained hydrogel mask to prevent a large amount of dehydration, a tensile strength test of the hydrogel was performed using a universal mechanical testing machine, and the hydrogel was compressed at a speed of 1mm/min and tested for its compressive strength, 10 samples were tested for each comparative example of example, and the average value of the measured values was recorded in table 2.

TABLE 1

TABLE 2

As can be seen from tables 1 and 2, the gel mask prepared by the scheme of the invention has excellent moisturizing performance, moisturizing performance and physical cooling performance, and in addition, the mask of the invention has short gelling time, good application performance and good mechanical performance.

Wherein the natural polysaccharide aqueous solution used in example 2 had a lower alginate concentration, and the lower alginate concentration resulted in a slower gelling speed, resulting in a greater drop distance and longer gelling time. In example 5, the amount of the ionic crosslinking agent solution was reduced, so that the gel was not completely formed, and thus partial dropping occurred. Example 6 results in a decrease in gel speed and a decrease in gel integrity after decreasing the concentration of ionic crosslinker, resulting in an increase in drop distance.

The gel formation time in comparative example 1 was prolonged compared to example 4, which is probably due to the fact that the concentration of the natural polysaccharide in comparative example 1 was too high, which resulted in an increase in the viscosity of the aqueous solution of the natural polysaccharide, which was detrimental to the penetration of the ionic crosslinking agent, resulting in a longer gel time. The gel formation time in comparative example 2 was also prolonged compared to example 4, probably due to the too high concentration of ionic crosslinker in comparative example 2, which resulted in rapid surface formation of a dense crosslinked network, affecting penetration of the ionic crosslinker, thus prolonging the gel time. Comparative example 5 has the lowest moisture content of the skin after use, which may be caused by two reasons, on one hand, the poor overall fitness and the poor overall moisturizing effect on the skin because comparative example 5 is directly formed and then applied to the face; on the other hand, because the directly-formed mask is formed by uniformly stirring the natural polysaccharide aqueous solution and the ionic cross-linking agent aqueous solution, a complete and compact gel cross-linking network can be formed, moisture can be more firmly locked in the gel, the moisture release effect is poor, and the moisture content of the skin is less improved.

2. And (3) testing the efficacy:

1. active ingredient slow release: pouring the natural polysaccharide aqueous solution loaded with rhamnose prepared in examples 1-8 and comparative examples 1,2 and 4 (the solution quality of each example and comparative example is equal) into a mould, uniformly spreading the natural polysaccharide aqueous solution, correspondingly spraying the ionic crosslinking agent aqueous solution prepared in the step (2) on the surface of the natural polysaccharide aqueous solution according to the formula proportion of the example or the comparative example, and taking out the natural polysaccharide aqueous solution from the mould after forming to obtain the hydrogel facial mask with basically the same shape; and (3) pouring the natural polysaccharide aqueous solution and the ionic cross-linking agent aqueous solution prepared in the comparative example 5 into a mould according to a ratio, stirring uniformly, waiting for forming, and taking out after forming to obtain the hydrogel mask with the basically same shape. The obtained hydrogel masks were immersed in 200mL of PBS buffer, respectively, and placed in a shaker at 37 ℃. 2mL of the liquid was aspirated at fixed intervals, and 2mL of fresh PBS buffer was added to ensure constant total volume. The active ingredient release was measured by HPLC (3 samples were tested per sample and averaged). The results are recorded in Table 3.

2. Skin irritation: for examples 1-8, comparative examples 1-2, and comparative examples 4-5, 100 volunteers between 20-45 years of age were individually selected for each group and trial experiments were performed without using any cosmetic product for three days before and after the volunteers. The gel mask is uniformly applied on the left cheek half, the left cheek half and the right cheek half are used as a control in the wet application process, the using condition of a volunteer is observed, and the skin condition of a patient within three days of using the mask is observed if the mask has no irritation, anaphylactic reaction and the like. The results are recorded in Table 4.

TABLE 3

	Cumulative release of active ingredient (%). 30min	Cumulative release of active ingredient (%)
			Example 1	52.61	85.86
Example 2	56.82	86.63
			Example 3	63.08	78.29
Example 4	55.05	81.06
			Example 5	60.03	74.58
Example 6	61.13	75.63
			Example 7	56.16	84.47
Example 8	51.28	77.47
			Comparative example 1	61.13	70.09
Comparative example 2	62.17	73.97
			Comparative example 4	53.35	86.31
Comparative example 5	45.66	67.39

TABLE 4

	Irritation (human)	Redness (human)	Whelk (human)	Drying (human)
					Example 1	0	0	0	0
Example 2	0	1	0	0
					Example 3	0	0	0	0
Example 4	0	0	0	0
					Example 5	0	0	1	0
Example 6	0	1	0	0
					Example 7	0	0	0	0
Example 8	0	0	0	0
					Comparative example 1	0	0	2	0
Comparative example 2	0	0	0	0
					Comparative example 4	3	2	1	0
Comparative example 5	2	1	0	1

As can be seen from the results in table 3, the gel masks prepared in examples 1 to 8 exhibited a good active ingredient release effect with an active ingredient release amount of 51.28% or more at 30min and an active ingredient release amount of 74.58% or more at 10 hours.

In comparative example 1, the concentration of the aqueous solution of natural polysaccharide was too high, and the release amount of active ingredient reached 61.13% at 30min, but the release amount was only 70.09% at 10h, because the viscosity of the solution was high at higher concentration of the aqueous solution of natural polysaccharide, which was not favorable for the penetration of ionic crosslinking agent, resulting in the formation of a dense gel structure on the surface layer, but loose inside, which was not favorable for the sustained release of active ingredient. Comparative example 2 similarly to the case of comparative example 1, the active ingredient is rapidly released in a short time because the concentration of the ionic crosslinking agent in comparative example 2 is too high, resulting in rapid formation of a dense crosslinking network on the surface, which affects penetration of the ionic crosslinking agent, thereby loosening the inside of the gel mask, not contributing to sustained release of the active ingredient.

Meanwhile, comparative example 5 adopts a conventional gel mask method, in which a natural polysaccharide aqueous solution loaded with an active ingredient and an ionic crosslinking agent aqueous solution loaded with a penetration enhancer are uniformly stirred and formed into a gel mask. As can be seen from table 3, the comparative example 5 has low release amounts of the effective components at both 30min and 10h, a slow early release rate, and a low total release amount, which may be due to the fact that the gel mask prepared by the conventional method forms a more complete and dense gel structure during the gel forming process, which blocks the components in the gel mask more "firmly" and is not favorable for the release of the effective components. The reason why the release amount of the active ingredient in the case of example 1 with the same formulation as that of comparative example 5 is significantly higher than that in the case of comparative example 5 both at 30min and 10h is probably because the gel is gradually formed from the surface to the inside by applying the natural polysaccharide aqueous solution on the skin surface and then spraying the ionic crosslinking agent aqueous solution in example 1, and the gelling method may cause the formation of channels similar to a "trumpet" shape in the gel structure, i.e., the channel aperture near the surface is smaller, and the channel aperture is larger closer to the skin, so that the channel in the shape of the "trumpet" is beneficial to the release of the active ingredient and moisture to the skin. Comparison between comparative example 5 and example 1 also shows that the preparation method of coating before spraying provided by the invention greatly improves the release amount of active substances.

As can be seen from table 4, in examples 1 to 8 and comparative examples 1 to 2, the addition method of adding the active ingredient to the aqueous solution of the natural polysaccharide and the penetration enhancer to the aqueous solution of the ionic crosslinking agent was adopted, so that fewer volunteers had adverse effects, and only 3 persons had reddened and pox when the facial mask was used and observed for three days, which was also related to the skin condition or diet condition of the volunteers themselves. Comparative example 1 two of the three days of observation showed pox formation, which was probably related to the volunteers themselves but also due to the excessive concentration of the aqueous solution of the natural polysaccharide in comparative example 1. The comparison example 4 adopts the mode that the active ingredients and the penetration enhancer are both added into the natural polysaccharide aqueous solution, and the comparison example 5 directly mixes the two solutions and then forms, in the test groups of the gel mask prepared by the two modes, 2-3 volunteers have irritation in the using process, and in the observation time of three days, the volunteers respectively have the conditions of redness, acne and dryness, which is probably because the penetration enhancer is uniformly distributed on one side of the mask close to the skin in the modes of the comparison example 4 and the comparison example 5, so that the penetration enhancer which has irritation to the skin directly contacts the skin in a larger dose, thereby generating irritation. It can also be shown by comparing example 1 with comparative examples 4-5 that the active substance and penetration enhancer are added into the two solutions respectively, and the two solutions are mixed to be coated and sprayed first, so that the stimulation of the penetration enhancer to the skin can be effectively reduced.

Claims

1. The mild gel mask is characterized by comprising a natural polysaccharide aqueous solution and an ionic crosslinking aqueous solution, wherein the natural polysaccharide aqueous solution comprises natural polysaccharide, an active ingredient and water, and the ionic crosslinking aqueous solution comprises an ionic crosslinking agent, a penetration enhancer and water.

2. The mild gel mask of claim 1 prepared by the method comprising:

(1) Adding natural polysaccharide and active ingredients into deionized water simultaneously or in batches, and stirring until the natural polysaccharide and the active ingredients are completely dissolved to obtain a natural polysaccharide aqueous solution;

(2) Adding the ionic crosslinking agent and the penetration enhancer into deionized water simultaneously or in batches, and stirring until the ionic crosslinking agent and the penetration enhancer are completely dissolved to obtain an ionic crosslinking aqueous solution;

3. The mild gel mask as claimed in claim 1, wherein the mass ratio of said natural polysaccharide to water is (1-6): 100, the mass ratio of the ionic crosslinking agent to the water is (0.5-3.5): 100.

4. the mild gel mask as claimed in claim 1, wherein the mass concentration of said active ingredient in the aqueous solution of natural polysaccharide is 0.001-5%, and the mass concentration of said penetration enhancer in the aqueous solution of ionic crosslinking is 0.5-10%.

5. The mild gel mask as claimed in claim 1, wherein said natural polysaccharide and water are present in a mass ratio of (2-6): 100, the mass ratio of the ionic crosslinking agent to the water is (1-2): 100.

6. the mild gel mask as claimed in claim 1, wherein the volume ratio of said aqueous solution of natural polysaccharide to said aqueous solution of ionic cross-linking is 1: (0.2-2).

7. The mild gel mask as claimed in claim 1, wherein said active ingredient is selected from the group consisting of one or more of polypeptide-based components, collagen-based components, plant extract-based components, polysaccharide-based components.

8. The mild gel mask as claimed in claim 7, wherein said polypeptide component is selected from the group consisting of acetyl hexapeptide-8, palmitoyl tripeptide-1, myristoyl pentapeptide-4, palmitoyl tetrapeptide-7;

the collagen component is selected from one or more of soluble collagen, hydrolyzed collagen and collagen;

the plant extract component is selected from one or more of Ginseng radix extract, kava extract, ganoderma extract, and flos Rosae Rugosae extract;

the polysaccharide component is selected from one or more of rhamnose, mannan, beta-glucan, dendrobe polysaccharide, ginseng polysaccharide, oat polysaccharide, tremella polysaccharide, konjac glucomannan, chitosan, galactose and agarose.

9. The mild gel mask of claim 1 wherein said penetration enhancer is selected from the group consisting of one or more of ethanol, carbitol, azone, hydroxyethylpiperazineethanesulfonic acid.

10. Use of a mild gel mask according to any one of claims 1 to 8 in a mask product with anti-ageing, whitening, anti-acne, soothing and moisturizing effects.