CN1158085C - Fe-Ca nutrient combination and its preparation method - Google Patents
Fe-Ca nutrient combination and its preparation method Download PDFInfo
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- CN1158085C CN1158085C CNB981085539A CN98108553A CN1158085C CN 1158085 C CN1158085 C CN 1158085C CN B981085539 A CNB981085539 A CN B981085539A CN 98108553 A CN98108553 A CN 98108553A CN 1158085 C CN1158085 C CN 1158085C
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- Prior art keywords
- milligram
- stichopus japonicus
- amount
- vitamin
- calcium acetate
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- 235000015097 nutrients Nutrition 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims abstract 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 20
- 239000000203 mixture Substances 0.000 claims abstract description 14
- 239000011575 calcium Substances 0.000 claims abstract description 13
- 239000000843 powder Substances 0.000 claims abstract description 13
- 239000000284 extract Substances 0.000 claims abstract description 12
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 10
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 10
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical class [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims abstract description 10
- 235000011092 calcium acetate Nutrition 0.000 claims abstract description 10
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 10
- 239000011718 vitamin C Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical class [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000008280 blood Substances 0.000 claims abstract description 6
- 210000004369 blood Anatomy 0.000 claims abstract description 6
- 241001465754 Metazoa Species 0.000 claims abstract description 5
- 150000001413 amino acids Chemical class 0.000 claims abstract description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims abstract description 4
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 4
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 4
- 241000965254 Apostichopus japonicus Species 0.000 claims description 16
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 12
- -1 ferrous porphyrin Chemical class 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 10
- 230000000035 biogenic effect Effects 0.000 claims description 9
- 239000001639 calcium acetate Substances 0.000 claims description 9
- 229960005147 calcium acetate Drugs 0.000 claims description 9
- 238000001914 filtration Methods 0.000 claims description 6
- 238000001802 infusion Methods 0.000 claims description 6
- 229960000583 acetic acid Drugs 0.000 claims description 5
- 238000000034 method Methods 0.000 claims description 5
- 238000001816 cooling Methods 0.000 claims description 3
- 239000012362 glacial acetic acid Substances 0.000 claims description 3
- 239000002244 precipitate Substances 0.000 claims description 3
- 238000001556 precipitation Methods 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- CPXBZKQKJVNZQF-UHFFFAOYSA-L [Cl-].[Cl-].[Fe+2].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical compound [Cl-].[Cl-].[Fe+2].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 CPXBZKQKJVNZQF-UHFFFAOYSA-L 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 238000002425 crystallisation Methods 0.000 claims description 2
- 230000008025 crystallization Effects 0.000 claims description 2
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 claims description 2
- 239000012141 concentrate Substances 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 239000000376 reactant Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 abstract description 6
- 235000011054 acetic acid Nutrition 0.000 abstract description 3
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 abstract description 3
- 235000011086 calcium lactate Nutrition 0.000 abstract description 3
- 239000001527 calcium lactate Substances 0.000 abstract description 3
- 229960002401 calcium lactate Drugs 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 3
- 229910052742 iron Inorganic materials 0.000 abstract description 3
- 235000013305 food Nutrition 0.000 abstract description 2
- 239000002994 raw material Substances 0.000 abstract description 2
- 239000013589 supplement Substances 0.000 abstract description 2
- 241000251511 Holothuroidea Species 0.000 abstract 3
- BTIJJDXEELBZFS-UHFFFAOYSA-K hemin Chemical compound [Cl-].[Fe+3].[N-]1C(C=C2C(=C(C)C(C=C3C(=C(C)C(=C4)[N-]3)C=C)=N2)C=C)=C(C)C(CCC(O)=O)=C1C=C1C(CCC(O)=O)=C(C)C4=N1 BTIJJDXEELBZFS-UHFFFAOYSA-K 0.000 abstract 2
- 244000061520 Angelica archangelica Species 0.000 abstract 1
- 235000001287 Guettarda speciosa Nutrition 0.000 abstract 1
- 150000001243 acetic acids Chemical class 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 235000002639 sodium chloride Nutrition 0.000 abstract 1
- 235000001465 calcium Nutrition 0.000 description 6
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 5
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 5
- 229960005069 calcium Drugs 0.000 description 5
- 206010006956 Calcium deficiency Diseases 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 238000010992 reflux Methods 0.000 description 2
- KSEBMYQBYZTDHS-HWKANZROSA-M (E)-Ferulic acid Natural products COC1=CC(\C=C\C([O-])=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-M 0.000 description 1
- 208000015710 Iron-Deficiency Anemia Diseases 0.000 description 1
- JQRLYSGCPHSLJI-UHFFFAOYSA-N [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 Chemical compound [Fe].N1C(C=C2N=C(C=C3NC(=C4)C=C3)C=C2)=CC=C1C=C1C=CC4=N1 JQRLYSGCPHSLJI-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- KSEBMYQBYZTDHS-HWKANZROSA-N ferulic acid Chemical compound COC1=CC(\C=C\C(O)=O)=CC=C1O KSEBMYQBYZTDHS-HWKANZROSA-N 0.000 description 1
- 229940114124 ferulic acid Drugs 0.000 description 1
- KSEBMYQBYZTDHS-UHFFFAOYSA-N ferulic acid Natural products COC1=CC(C=CC(O)=O)=CC=C1O KSEBMYQBYZTDHS-UHFFFAOYSA-N 0.000 description 1
- 235000001785 ferulic acid Nutrition 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 235000013402 health food Nutrition 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000002117 porphyrinogenic effect Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004781 supercooling Methods 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The present invention discloses a Fe-Ca nutrient composition and a preparation method thereof. The composition is prepared from chlorohemin, creta preparata, sea cucumber extracts, vitamin C and angelica powder. The preparation method comprises the following steps: the blood of a large animal reacts with glacial acetic acids and sodium chlorides to form the chlorohemin; calcium lactate or the final filtered solution in previous step reacts with oyster shell powder to form biological source calcium acetates, etc.; sea cucumber extracts which contain various amino acids and low-molecular proteins are extracted by the way that alcohol is added in the sea cucumber leach solutions; the raw materials are prepared by a certain proportion, and the composite type nutrient solution which can supplement Fe and Ca can be produced and is suitable for health-care foods and medicines.
Description
The invention belongs to a kind of Fe-Ca nutrient combination, relate in particular to food and medicine that hemopoietic is replenished the calcium.
As everyone knows, iron deficiency anemia and calcium deficiency all are one of main nutritional problem of facing of the present world.Anemia and calcium deficiency are particularly outstanding to women and child, and the problem of old people's calcium deficiency also is on the rise.Adopt heme iron, promptly ferrous porphyrin is had it long ago as primary raw material manufacturing blood-forming agent; It is also very general to adopt various activated calciums that human body is nourished, but handle is replenished the calcium and hemopoietic combines, and nourishes simultaneously, then is the cry of nutrition educational circles unanimity always.
Purpose of the present invention just provides the composition and method of making the same that a kind of iron supplement is also replenished the calcium and contained the blood circulation invigorating efficacies composition.
Technical scheme of the present invention is achieved in that
At first, adopting known traditional method to utilize the draught animal animal blood to mix with glacial acetic acid to add sodium chloride to mix by a certain percentage to reflux boils again, the iron chloride porphyrin is separated out with crystal form, through supercooling, filtration, collection precipitate begin edible ferrous porphyrin.
Then, with the final filtrate collection dilution in the above-mentioned steps.This filtrate is about the acetic acid about 40%, is diluted to 20% acetic acid, and to wherein adding oyster shell powder, question response is complete, leaves standstill filtration subsequently, removes residue, collects filtrate, through concentrating, just can obtain the biogenic calcium acetate again.
Secondly, utilize the Stichopus japonicus infusion of processing of aquatic products unit to make Stichopus japonicus extract.The Stichopus japonicus infusion is purified, filters, add ethanol then, make and contain several amino acids in the infusion and low molecular protein is separated out with precipitated form, by centrifugal or filter type collecting precipitation thing, drying more refiningly can get the beche-de-mer abstract.
At last, buy vitamin C and Radix Angelicae Sinensis powder by market, with itself and above-mentioned make ferrous porphyrin, biogenic calcium acetate and Stichopus japonicus extract by a certain percentage mix homogeneously just can be made into the alleged compositions of the present invention.
The main uses of this compositions is to be used as health food or health medicine, and dosage form can be capsule or tablet.Ferrous porphyrin and biogenic calcium acetate are used for enriching blood and also replenish the calcium; Stichopus japonicus extract provides several amino acids, can reconcile metabolism, and unit is supported in nourishing; Vitamin C is the promoter of ferrum calcium absorption; Ferulic acid in the Radix Angelicae Sinensis powder then can be pleased face by rich flesh.The compatibility of multiple composition can play the compound action of getting twice the result with half the effort.
Embodiment 1: it is an amount of to get the draught animal animal blood, mix with glacial acetic acid by 1: 4 weight ratio and to add sodium chloride again and mix to reflux and boil, keep certain temperature and time, iron porphyrin begins to separate out with the rust crystallization, and after reacting completely, cooling is left standstill, filter, the filtrate water is cleaned, and subsequent drying collects and is edible ferrous porphyrin.Secondly, with final filtrate collection.This filtrate is about 40% acetum, gets a certain amount of redilution and becomes 20% acetum, adds 40 order oyster shell powders of response magnitude subsequently.Carrying out along with reaction can produce a large amount of bubbles, and temperature also can rise naturally.Treat that bubble disperses, after reacting completely, leave standstill filtration, remove residue, collect filtrate, through concentrating, can make the biogenic calcium acetate again.
Secondly, utilize the infusion in an amount of Stichopus japonicus processing, purify after-filtration, add an amount of ethanol in filtrate, several amino acids and the low molecular protein thing that be contained in the filtrate this moment can be separated out with sedimentary form.By centrifugal or filter type collecting precipitation thing, drying is made edible Stichopus japonicus abstract again.
Secondly, choose qualified vitamin C and Radix Angelicae Sinensis powder as adjuvant.
At last, prepare said composition as required, its content is respectively:
Ferrous porphyrin 30-150 milligram
Biogenic calcium acetate 200-400 milligram
Stichopus japonicus extract 100-200 milligram
Vitamin C is an amount of
Radix Angelicae Sinensis powder is an amount of.
Embodiment 2: it is an amount of to get the draught animal animal blood, prepares ferrous porphyrin as stated above; Prepare the edible Stichopus japonicus extract by last routine method then.Commercially available calcium lactate powder and vitamin C are measured adding wherein in accordance with regulations, form said composition, its content is respectively:
Ferrous porphyrin 30-150 milligram
Calcium lactate 200-400 milligram
Stichopus japonicus extract 100-200 milligram
Vitamin C is an amount of.
Claims (2)
1. a Fe-Ca nutrient combination is characterized in that the milligram by ferrous porphyrin 30-150, biogenic calcium acetate 200-400 milligram, and Stichopus japonicus extract 100-200 milligram and appropriate vitamin C and Radix Angelicae Sinensis powder are formed.
2. the preparation method of a Fe-Ca nutrient combination is characterized in that processing step comprises:
2.1 adopt known traditional method that the draught animal animal blood was mixed with glacial acetic acid by weight 1: 4 and the mixture backflow of sodium chloride is boiled, the iron chloride porphyrin is separated out with the rust crystallization, after reacting completely, cooling, filtration, collection precipitate promptly obtain edible ferrous porphyrin;
2.2 the final filtrate in the above-mentioned steps is got a certain amount of 20% the acetum that is diluted to, add the response magnitude oyster shell powder then, produce a large amount of bubbles during reaction, temperature also raises voluntarily, treat that bubble disperses, cooling is left standstill, and removes residue, collect reactant solution and concentrate, can get the biogenic calcium acetate;
2.3 adopt a certain amount of Stichopus japonicus infusion, purification filtering in advance, add an amount of ethanol then, several amino acids and the low molecular protein that be contained in the Stichopus japonicus infusion this moment are just separated out in the precipitate mode, by centrifugal, separate or filter the collecting precipitation thing, make edible Stichopus japonicus extract through super-dry again;
2.4 with the ferrous porphyrin that said method makes, the biogenic calcium acetate, Stichopus japonicus extract and commercially available vitamin C, Radix Angelicae Sinensis powder promptly becomes the alleged Fe-Ca nutrient combination of the present invention according to the corresponding proportion mix homogeneously;
2.5 the proportioning of Fe-Ca nutrient combination is:
Ferrous porphyrin 30-150 milligram
Biogenic calcium acetate 200-400 milligram
Stichopus japonicus extract 100-200 milligram
Vitamin C is an amount of
Radix Angelicae Sinensis powder is an amount of.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB981085539A CN1158085C (en) | 1998-05-04 | 1998-05-04 | Fe-Ca nutrient combination and its preparation method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB981085539A CN1158085C (en) | 1998-05-04 | 1998-05-04 | Fe-Ca nutrient combination and its preparation method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1211423A CN1211423A (en) | 1999-03-24 |
| CN1158085C true CN1158085C (en) | 2004-07-21 |
Family
ID=5219656
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB981085539A Expired - Fee Related CN1158085C (en) | 1998-05-04 | 1998-05-04 | Fe-Ca nutrient combination and its preparation method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1158085C (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1985850B (en) * | 2006-12-26 | 2010-12-01 | 成都自豪药业有限公司 | Oral medicine composition for replenishing Ca, Mg and Fe and its preparing method and use |
| CN101020047B (en) * | 2007-03-06 | 2011-06-22 | 华南农业大学 | Health food containing calcium reinforcing agent |
| CN103005528B (en) * | 2007-07-08 | 2015-02-11 | 谭攸恒 | Preparation method of sea cucumber extract |
| CN101156947B (en) * | 2007-09-20 | 2011-01-19 | 黄世宽 | Ginseng source peptide albumen, its preparing method and application |
-
1998
- 1998-05-04 CN CNB981085539A patent/CN1158085C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1211423A (en) | 1999-03-24 |
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| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
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Granted publication date: 20040721 Termination date: 20130504 |