CN1156273C - Far infrared nano plaster - Google Patents
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- CN1156273C CN1156273C CNB011382287A CN01138228A CN1156273C CN 1156273 C CN1156273 C CN 1156273C CN B011382287 A CNB011382287 A CN B011382287A CN 01138228 A CN01138228 A CN 01138228A CN 1156273 C CN1156273 C CN 1156273C
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Abstract
The present invention relates to far infrared nanometer plaster which comprises a lining layer part and a medicine layer part. The far infrared nanometer plaster is characterized in that the lining layer part orderly comprises an adhesive layer, an oxygenizing and heating layer and a far infrared layer from the outside to the inside, wherein the far infrared layer comprises a fabric containing far infrared ceramic powder and can transmit far infrared rays. The medicine layer contains plaster prepared from Chinese herbal medicine powder pulverized into the nanometer level of 1 nm to 1000 nm. The far infrared nanometer plaster takes the traditional method of hot compress of medicine in Chinese medicine as a basis, combines the medical health care function of far infrared rays to a human body, and is matched with traditional Chinese medicine processed via a nanotechnology. Thus, the far infrared nanometer plaster can reach the effects for promoting blood circulation, dispelling stasis, reducing edema, alleviating pain, expelling wind, clearing away cold, stretching channels and removing meridian obstruction.
Description
Technical field
The present invention relates to the Chinese medicine plaster, relate in particular to a kind of based on nanometer Chinese medicine, in conjunction with the far infrared nano plaster of constant temperature heating technology and far-infrared technique treatment rheumatism class and soft tissue injury class disease.
Background technology
As everyone knows, general ointment is owing to the too small restriction of skin pore, and the drug osmotic amount is very little, and its curative effect is restricted.For addressing this problem, released the plaster that adopts common exothermic material to produce heat on the market, accelerate local blood circulation, improve therapeutic effect.The temperature that this plaster weak point is an exothermic material is wayward, and temperature is too high can skin ambustion, does not lowly excessively have therapeutic effect, and drug effect can not be given full play to.
Chinese patent disclosed a kind of name and has been called " far infrared health care plaster " on August 11st, 1999, and the patent No. is 98223753 utility model patent.The fabric that contains the far infrared ceramic powder end is adopted in mounting by material of this plaster, utilizes far ir ray to pass medicine and shines human body, and it is warm that human body is produced, and the regeneration power with blood circulation promoting, promotion tissue increases drug effect.Though above technology can increase drug effect, effect is not clearly, still can not bring into play the effect of medicine fully.
Summary of the invention
The objective of the invention is in order to solve the deficiency that the above-mentioned background technology exists, propose a kind ofly can give full play to drug effect, the far infrared nano plaster that human body is fully absorbed makes it have good curative effect.
Traditional Chinese medical science traditional theory thinks that the size of external use plaster effect is decided by the degree of absorption of human body to effective ingredient in the plaster.The present invention is combined into far-infrared technique, constant temperature heating technology and medicament nano technology together, it is partly formed by mounting backing layer part and medicine layer, it is characterized in that the described backing layer part of mounting is made of adhesive-layer, oxidation heating layer and far infrared layer from outside to inside successively, above-mentioned far infrared layer is made of the far-infrared fabric that contains far-infrared ceramic powder, can be emitting far-infrared; Described medicine layer is to be ground into the plaster that the Chinese herbal medicine medicamental pulverata of the nanorize of 1-1000nm is made.
Described oxidation heating layer is mixed and processed by a certain percentage by kieselguhr, active carbon, sodium chloride, reduced iron powder and water, and its heating up time, maximum temperature was smaller or equal to 54 ℃ smaller or equal to 10 minutes, and temperature duration was greater than 6 hours more than 40 ℃.It can make the local pyrexia of skin table organization, the pore expansion, and the skin table is perspired, and helps the absorption of medicine like this, promotes ointment to bring into play drug effect better.
In the far infrared layer, contain far infrared ceramic powder 5-6 gram in per 100 gram far-infrared fabrics, can launch the far ir ray of 4-14 micron, and human body also is a far-infrared radiator, also is absorber simultaneously, the optimal wavelength that it can absorb also is the 4-14 micron.Under the effect of far infrared radiation, the molecular chemistry key chattering frequency in human body skin and the subcutaneous tissue cell is accelerated, and the temperature of tissue is raise, blood flow increases, strengthen the permeability of skin, accelerated metabolism and body-internal-circulation, helped the conveying of nutrient in the body.Simultaneously, the heat energy that far ir ray can be regulated the oxidation heating layer transmits, and plays balanced effect of conducting heat, and avoids the too high skin ambustion of temperature, and temperature is crossed the problem of low poor effect.
Described medicine layer is to be ground into the plaster that the Chinese herbal medicine medicamental pulverata of the nanorize of 1-1000nm is made.It can increase the absorbance of medicine, improves bioavailability, helps preserving effective ingredient, improves drug effect.The more important thing is that it can make the effective ingredient of medicine fully see through skin, enters human muscular tissue, even can enter blood capillary, arrives affected part and affected part depths, makes the efficacy of a drug of the present invention stronger, effect is better.
The present invention to the medical health care effect, is equipped with the Chinese medicine through nanotechnology treatments in conjunction with far infrared based on traditional Chinese medical science traditional drugs rubbing hot medicated compress again, can play blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and expelling wind and cold relaxes through the effect of collateral dredging.
Clinical experiment report (seeing the clinical observation brief summary of the far infrared nano plaster that Wuhan City institute of traditional Chinese medicine and Wuhan City five hospitals do) has been done to the present invention respectively by Wuhan City institute of traditional Chinese medicine and Wuhan City five hospitals, the result shows, the present invention has " blood circulation promoting and blood stasis dispelling; reducing swelling and alleviating pain; go the wind dehumidifying, relax through collateral dredging " effect; Pain, swelling, handicapped recovery that the elimination acute soft tissue injury is caused are a kind of ideal products; Arthralgia that diseases such as anemofrigid-damp arthralgia are caused etc. truly has good short term effect; Particularly, improve joint function disturbance and local fear of cold symptom, obvious curative effects is arranged easing the pain; It is safe and reliable, has no side effect.
Description of drawings
Accompanying drawing is a profile of the present invention.
The specific embodiment
The present invention forms by mounting backing layer part and medicine layer part 5, and the described backing layer part of mounting is made of ventilative adhesive-layer 1, oxidation heating layer 3 and far infrared layer 4 from outside to inside successively.Described ventilative adhesive-layer 1 is the adhesive tape of band air-vent, and one side inwardly has viscose glue, is used for the present invention is attached at human body skin.
Far infrared layer 4 is positioned at the another side of oxidation heating layer 3, is made of the far-infrared fabric that contains far-infrared ceramic powder, and 100 gram far-infrared fabrics contain far infrared ceramic powder 5-6 gram, can launch the far ir ray of 4-14 micron, and far infrared transmissivity is 84%.
Medicine layer 5 is medicine boxs with cover, is positioned at the surface of mounting backing layer part inner face far infrared layer 4, and ointment can be placed in this medicine box, is convenient to change.
The ointment that the present invention adopts can be selected multiple Chinese herbal medicine formula for use according to the difference of conditions of patients, no matter is any prescription, in process for preparation, all relevant medicine wherein will be ground into the medicamental pulverata of 1-1000nm, is being mixed with ointment then.The proportioning of present embodiment ointment consists of: Moschus 0.5g, Borneolum Syntheticum 1.5g, Camphora 4g, Sanguis Draxonis 2.5g, Rhizoma Et Radix Notopterygii 3.5g, Olibanum 3.5g, Myrrha 3.5g, Flos Carthami 4g, Rhizoma Chuanxiong 2g, Rhizoma Coptidis 3g, Radix Angelicae Sinensis 4g, Cinnabaris 3g.More than in the 12 flavor medicines, Rhizoma Et Radix Notopterygii, Olibanum, Myrrha, Rhizoma Chuanxiong, Radix Angelicae Sinensis are extracted volatile oil, standby; After medicinal residues dry, mix, add 8 times of amount 80% ethanol with Flos Carthami, Rhizoma Coptidis, reflux, extract, twice, each two hours, filter, merging filtrate, recovery ethanol are 1.10 extractum to relative density; Moschus, Borneolum Syntheticum, Camphora, Sanguis Draxonis, Cinnabaris are broken into the powder of 1-1000nm respectively at superfine powder under the ultralow temperature, standby; Other gets the basic cream of an amount of oil, behind the heating and melting, adds above-mentioned extractum, and fully stirring and dissolving is put after filtering, stirring and is chilled to the thick paste shape, stirs to add volatile oil and Moschus, Borneolum Syntheticum, Camphora, Sanguis Draxonis, Cinnabar down, and the mixing of milling is at last made ointment.
This ointment adopts CN92243315.5 " a kind of subzero treatment case " patented technology, under-24--190 ℃ low-temperature receiver environment, carries out extra-fine grinding, obtains ultra-fine Chinese medicinal powder (can reach 200nm as Cinnabaris).
Present embodiment has blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, and expelling wind and removing dampness relaxes through the function of collateral dredging.It cure mainly in the congestion such as cervical spondylosis, scapulohumeral periarthritis, lumbar muscle strain, intervertebral disk hernia, soft tissue injury, rheumatic arthritis stop, the cloudy various pain that cause of stagnating of meridians, disease such as movable unfavorable.
Using method: external, be affixed on the illness place, each one, once a day.
Points for attention: serious allergy sufferers of skin or skin injury person, anemia of pregnant woman's forbidding.
The clinical observation brief summary of far infrared nano plaster
The hospital of traditional Chinese hospital, Wuhan City
Far infrared nano plaster is a kind of expelling wind and removing dampness of development in science and technology company limited development between the world, Wuhan, the external use plaster of reducing swelling and alleviating pain, blood circulation promoting and blood stasis dispelling, temperature three-way meridian.My institute is subjected to the trust of its research unit, and between August 23 to October 22 calendar year 2001 far infrared nano plaster having been carried out clinical efficacy and safety is observed, existing 50 routine observed results with complete clinical data are reported as follows:
Clinical data
One, case source
According to the testing program requirement, chosen outpatient service and inpatient respectively and amounted to 50 examples, ward 20 examples wherein, outpatient service 30 examples.
Two, physical data
Sex: male 29 examples, women 21 examples, men and women's ratio is 1.38: 1
Age: maximum 58 years old age, minimal ages 18 years old, average 32.88 years old.
Occupation: cadre's 23 examples, workman's 17 examples, student's 10 examples.
The course of treatment: 1 day 7 example, 2 days 22 examples, 3 days 21 examples, average course of treatment 1.68 days.
The position:
Ankle shank knee joint thigh side of body waist elbow forearm wrist adds up to
4 11 3 14 2 1 2 2 6 5 50
The disease feelings:
Slight moderate severe adds up to
9 20 21 50
Symptom:
The muscle spasm of pain and swelling tenderness limitation of activity
Case is selected
Three, choice criteria
1. the men and women patient in age 18-65 year;
2. closure is dampened and spraining property soft tissue injury (as the pain at positions such as tendon, ligament, muscle and joint, bitterly, symptoms such as swelling and dysfunction) emphasis: with micromelia backbone and joint part wound, the course of disease is no more than 2 all persons;
Four, case exclusion standard
1.18 below year, the over-65s person, gestation or women breast-feeding their children have allergies person to food, have a liking for the cigarette alcoholic;
2. skin injury or open wound person are arranged;
3. psychotic that can not fine cooperation;
4. do not meet inclusion criteria, not medication in accordance with regulations can't be judged curative effect, or data is not congruent affects the treatment or safety judgement person.
Five, case is rejected standard
1. because of other unexpected reason (as going on business etc.) therapy discontinued person;
Because of the skin serious adverse reaction (as) must drug withdrawal person, but need include safety evaluatio in.
The case of rejecting all should be recorded faithfully reason, data is appropriate deposit for future reference.
Six, diagnostic criteria
Injure extremity corresponding site pain in addition, swelling, tenderness, muscle spasm, dysfunction and skin are scorching hot etc. as the diagnostic criteria of this research.
Seven, the assessment of severity extent
1, (Verbal rating scale VRS) judges the medication front and back by the doctor to pain degree main suit staging
Pain degree changes.
0=does not have pain
The 1=mild pain, can stand, orthobiosis, it is undisturbed to sleep.
The 2=moderate pain, pain is obvious, can not tolerate, and sleep is disturbed, and requires to keep orthobiosis with analgesic.
The 3=severe pain, sharp ache, sleep is subjected to serious interference, is moved.
2, (Visual analogue scale VAS) judges that by disease medication front and back pain degree changes to pain degree Visual Analog scale method.Establish 0 earlier for painless, 10 are the extreme pain in the imagination, and 0 → 10 10 line segments such as branch such as grade draw.Make fork (*) by the patient according to the pain degree of oneself on this line segment, patient's pain degree is represented in the site of making fork.
0=does not have pain
1-4: mild pain
5-7: moderate pain
8-10: severe pain
3, local tenderness
0 minute: no tenderness, severe or do not have pain when doing maximum activity;
1 minute: mild tenderness, edge, joint or touch ligament seasonal disease person pain is arranged, but passive activity is not limited;
2 minutes: the moderate tenderness, patient claims to have pain, and frowns discomfort, and activity is slightly limited;
3 minutes: the severe tenderness, patient claimed and shrinks back that passive activity is seriously limited ill.
4, swelling
0 minute: no swelling;
1 minute: mild swelling, soft tissue swelling;
2 minutes: severe swelling, soft tissue swelling, companion's hydrarthrosis.
5, merit has obstacle
0 minute: no dysfunction, comings and goings can be done in the joint;
1 minute: slight dysfunction, limitation of activity, but still can be engaged in normal activity;
2 minutes: the moderate dysfunction, obviously limitation of activity is taken care of oneself, and can not be engaged in general activity;
3 minutes: the severe dysfunction, or can't take care of oneself.
6, limitation of movement
0 minute: no limitation of movement, the scope of joint motion is normal;
1 minute: slight limitation of movement, the scope of joint motion in normal range 80%;
2 minutes: moderate limitation of movement, the scope of joint motion in normal range 50%;
3 minutes; Severe limitation of movement, the scope of joint motion in normal range 30%.
7, muscle spasm
0 minute: normal
1 minute: muscle is spasm slightly, and elasticity is normal
2 minutes: muscular spasm, poor flexibility
3 minutes: spasm such as tabular, elasticity disappeared
Eight, state of an illness evaluation
With pain (VRS, VAS), swelling, tenderness and dysfunction score addition, and by the following standard rating state of an illness: light＜5; Middle 5-10; Heavy＞10.
In the test except that every of VAS by patient's observed and recorded, sundry item is by doctor's observed and recorded respectively before and after pasting with nanometer.
Verification method
One, the method and the course of treatment
Apply ointment or plaster at damage location, the world logical (far infrared nano plaster), paste every day one, 6 days was 1 course of treatment, carried out statistical summary after 1 course of treatment.
Two, observe small records
During the person, observe injury, treatment front and back pain, swelling, tenderness, muscle spasm, the change situation of dysfunction and skin temperature, the above index of the itemized record of at every turn changing dressings, and the untoward reaction in the medication process in strict accordance with plan.During medication, stop using all medicine for external use and oral medicine.
Three, curative effect judging standard
Curative effect is judged the branch produce effects, and is effectively progressive, invalid, four grades.
Evaluation methodology is with pain (VRS, VAS) local tenderness, swelling, the function damage and the impaired comprehensive score computation percent that moves: total score * 100% before curative effect (the total score in total score-treatment back before the treatment)/treatment.Produce effects＞80%, effective 51-80%, progressive 30-50%, invalid＜30%.
Therapeutic outcome
One, total effects
This organizes 50 examples, produce effects 27 examples, and effective 17 examples, progressive 6 examples, effective percentage is 88.00%.
The effectively progressive invalid total effective percentage % of produce effects
13 14 6 0 50 88.00％
Two, card marquis curative effect
Card marquis curative effect
Average integral * ± 50
Treatment back P value before the treatment
Pain 2.50 ± 0.54 0.52 ± 0.65＜0.01
Swelling 2.04 ± 0.83 0.28 ± 0.54＜0.01
Tenderness 2.54 ± 0.58 0.3 ± 0.46＜0.01
Muscle spasm 1.50 ± 1.07 0.12 ± 0.33＜0.01
Dysfunction 1.48 ± 0.97 0.14 ± 0.45＜0.01
In the table result show that this product is all deposited highly significant to the improvement of symptoms such as pain, swelling, tenderness, muscle spasm, dysfunction must difference.
Three, the state of an illness and curative effect
Severity extent and therapeutic effect relationship
The effectively progressive invalid total of state of an illness produce effects
Slight 72009
Moderate 12 620 20
Severe 8940 21
Four, age and therapeutic effect relationship
Age and therapeutic effect relationship
The effectively progressive invalid total of age produce effects
18-30 2 7 2 0 11
31-45 9 6 3 0 18
46-60 16 4 1 0 21
Five, untoward reaction is observed
50 routine cases have been carried out the safety observation during treating, the money part is complete, and all not seeing has obvious adverse reaction.
The clinical observation conclusion
1, treating 50 routine acute soft tissue injuries observation total effective rates through far infrared nano plaster is 88.00%.Various therapeutic effect of syndrome are learned by statistics and are handled, and all there is highly significant difference P value＜0.01, illustrate that far infrared nano plaster is a kind of ideal product to pain, swelling, the handicapped recovery that the elimination acute soft tissue injury causes.
2, far infrared nano plaster is to have " blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, go wind dehumidifying, relax through collateral dredging ", adds the high-tech technology, develops the modern Chinese medicine external and pastes, and is clinical easy to use, painless, is worth further investigation and promotes.
3,50 routine clinical safety are observed, and do not see untoward reaction, do not have erythra and spiritual neural pathological changes to occur, thus can be long-term, use repeatedly, safe and reliable.
Far infrared nano plaster clinical observation brief summary
Wuhan City five hospitals
Far infrared nano plaster is a kind of blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, expelling wind and removing dampness, the easypro external use plaster through collateral dredging of development in science and technology company limited development between the world, Wuhan.My institute is subjected to the trust of its research unit, from August 23 calendar year 2001 between October 22 far infrared nano plaster having been carried out clinical efficacy and safety is observed, existing 30 routine observed results with complete clinical data are reported as follows:
Physical data:
Sex: man: 17 example woman: 13 routine men and women's ratio is: 1.31: 1:
Age: maximum 63 years old age, minimal ages 19 years old, average 42.5 ± 12.3 years old
Occupation: workman's 8 examples, cadre's 16 examples, student's 6 examples
The course of disease: the longest 30 years, the shortest 2 months, average 7.23 ± 7.25 years
Function of joint classification: one-level 11 examples; Secondary 18 examples; Three grade of 1 example
Study subject is selected:
" the new Chinese medicine clinical research guideline " and Chen Guiting, the Xue Saiqin that sent out portion according to Ministry of Health of the People's Republic of China in 1993 compile " the rheumatismal combination of Chinese and Western medicine diagnosis and treatment standard " of first national combination of Chinese and Western medicine rheumatism academic conference revision (in April, 1988, Kunming) of quoting in " up-to-date domestic and international disease treatment standard " and formulate this treatment standard and definite study subject.
One, diagnostic criteria and disease standard
(1) diagnostic criteria:
Rheumatic arthralgia
(1) the evil invasion and attack of rheumatism history is arranged.
(2) symptom: have that joint or muscle are miserable, numb, pain even huge pain, movable difficulty, meet cold or Changes in weather (cloudy day, rain, the blow) state of an illness increases the weight of.
(3) sign: movable function is limited due to the arthralgia of getting involved, but alleviates after the activity, and most cases are the pain pneumonedema only, the minority case in the joint around mild swelling.(no red heat)
(2) syndrome standard
Rheumatic arthralgia cold-damp resistance network disease: limbs joint cold type of pain, heavy or swelling, local fear of cold, color of the leather are not red, not hot, the pain increase in intensity under coldness pain alleviated while getting warmth that touch.
Two, test case standard
1, includes the case standard in
Allly meet the Western medicine diagnose standard and differential diagnosis in tcm standard person can include the test case in.
2, get rid of the case standard
(1) age is under-18s and over-65s person, pregnant person.
(2) severe malnutrition, or accompany serious systemic disease such as severe cardiac, brain, liver, kidney, hemopoietic system and mental patient.
(3) do not meet the standard of including in, or do not adhere to treatment, drop by the wayside, or add and use other therapies, can't judge curative effect, or data person entirely.
(4) joint deformity, maimed person, disability person are arranged.
Test method:
In " the medical apparatus and instruments new-product management Tentative Measures " developed and published according to country medicine office " the medical device product clinical research requirement " of adnexa one regulation carry out.Concrete grammar is as follows:
One, safety observation:
This test only observes that local skin has no adverse reaction and vital sign.
Two, health giving quality observation
Rheumatic arthralgia: count in functional classification, swelling, pain degree, the joint in emphasis observation pathological changes joint.
Three, observational technique:
Points for attention:
1, uses and directly do not contact skin night,, should be specifically noted that for child and skin sensitivity person in order to avoid burn.
2, this product has slightly paintedly to skin and medicated clothing, and clear water can be cleaned.
3, this product is avoided orally, and this product is pollution-free, and dark Liang Chu deposits.
Observed and recorded:
By unified clinical research scheme with observe table, printing is bound into book form, and provides to observer's hands, observes, record practically, and carries out corresponding rescue and prepare, and organizer is the chief physician, and the participant possesses attending doctor academic title and certain capacity of scientific research.
Four, the course of treatment:
6 days is a course of treatment.
Result of the test:
One, efficacy evaluation result:
(1) foundation: " up-to-date domestic and international medical diagnosis on disease the standard " (Xueyuan Press of compiling according to Ministry of Health of the People's Republic of China the clinical guidance principle of lumbago " new Chinese medicine treatment " and Chen Guiting, Xue Saiqin in " the new Chinese medicine clinical research guideline " developed and published in 1993, in January, 1991) be that " the rheumatismal combination of Chinese and Western medicine diagnosis and treatment standard " in (in April, 1988, Kunming) revised in first national combination of Chinese and Western medicine rheumatism academic conference of quoting.
(2) efficacy assessment standard: foundation is with " study subject selection ".
Rheumatic arthralgia
1, clinical cure: symptom all disappears, and it is normal that functional activity recovers; Integration 〉=85%
2, produce effects: symptomatology is eliminated or cardinal symptom is eliminated, and function of joint is recovered substantially, can participate in operate as normal and work; Integration 〉=50%
3, effective: cardinal symptom is eliminated substantially, and main function of joint is recovered substantially or had made marked progress, and can't take care of oneself to transfer to can take care of oneself, and perhaps loses the job and work capacity transfers work to and ability to work is recovered to some extent; Integration＞20%.
4, invalid: and compare before the treatment, each side does not all have progress, integration＜20%.
Two, state of an illness classification
1, function of joint classification
(1) level: can do comings and goings.
(2) level: moderate is limited, though there is one.
(3) level: obviously limited: as can only to take care of oneself, but can not be engaged in general activity.
(4) level: bed or seat crouch, and can't take care of oneself.
2, symptom and sign classification
Local fear of cold, pain increase in intensity under coldness, lack of appetite is indigestion and loss of appetite, and is weak, and meter 1 minute is arranged; There is not 0 fen.
Arthroncus: do not have 0 fen; Slight 1 minute; Obvious 2 minutes; Serious 3 minutes.
Arthralgia: do not have 0 fen; Accidental, dull pain 1 minute; Heavier, joint motion is limited to influence work 2 minutes; Heavy, the joint can not be movable significantly, can not adhere to work, 3 minutes.
Amyotrophy: have 1 fen; There is not 0 fen.
Counting in the joint: does not have 0 fen; 1-3 joint 1 minute; 4-6 joint 2 minutes; More than 63 minutes.
Therapeutic outcome
One, total effects
This organizes 30 examples, produce effects 16 examples, and effective 9 examples, progressive 5 examples, effective percentage is 83%.
Two, card marquis curative effect
Card marquis curative effect
Average integral * ± 50
Treatment back P value before the treatment
Local fear of cold 0.43 ± 0.31 0.22 ± 0.26＜0.01
Arthroncus 1.72 ± 0.63 0.3 ± 0.41＜0.01
Arthralgia 2.06 ± 0.87 0.32 ± 0.54＜0.01
Amyotrophy 0.68 ± 0.37 0.25 ± 0.21＜0.01
The joint counts 1.4 ± 0.92 0.2 ± 0.63＜0.01
Three, the state of an illness and curative effect
Severity extent and therapeutic effect relationship
The effectively progressive invalid total of state of an illness produce effects
Slight 41005
Moderate 7230 12
Severe 5620 13
Four, untoward reaction is observed
30 routine cases have been carried out the safety observation during treating, all information, all not seeing has obvious adverse reaction.
Discuss: the sick traditional Chinese medical science arthromyodynia category that belongs to of rheumatic arthralgia, its cause of disease is many to form because of the damp that is affected by the cold is mingled with.The development in science and technology company limited is at anemofrigid-damp arthralgia between the world, Wuhan, developed the world logical (far infrared nano plaster), through my section the patient of 30 routine rheumatic arthralgias is carried out clinical observation result and show, the world logical (far infrared nano plaster) has tangible clinical efficacy to arthralgia, aversion to cold and the dysfunction of improving, alleviating due to the anemofrigid-damp arthralgia.Before and after learn handling by statistics significant difference p value＜0.01 is arranged, clinical total effective rate 83%, and have no adverse reaction through observation this product skin is not had obvious stimulation.
The clinical observation conclusion:
1, far infrared nano plaster arthralgia that diseases such as anemofrigid-damp arthralgia are caused etc. truly has good recent clinical efficacy, particularly to easing the pain, improves joint function disturbance and local fear of cold symptom, and obvious curative effects is arranged.
2, far infrared nano plaster is clinical safe in utilization, convenient, cheap, has good market prospect, and suggestion is produced in batches, meets clinical needs.
Claims (7)
1, a kind of far infrared nano plaster, partly form by mounting backing layer part and medicine layer, it is characterized in that the described backing layer part of mounting is made of adhesive-layer, oxidation heating layer and far infrared layer from outside to inside successively, above-mentioned far infrared layer is made of the fabric that contains far-infrared ceramic powder, can be emitting far-infrared; Described medicine layer is to be ground into the plaster that the Chinese herbal medicine medicamental pulverata of the nanorize of 1-1000nm is made.
2,, it is characterized in that containing far infrared ceramic powder 5-6 gram in per 100 gram far-infrared fabrics described in the far infrared layer, but emission wavelength is the far infrared of 4-14 micron according to the described far infrared nano plaster of claim 1.
3,, it is characterized in that described oxidation heating layer is mixed by the percentage by weight of 11.59% kieselguhr, 23.88% active carbon, 2.9% sodium chloride, 45% reduced iron powder and 15.68% water to form according to the described far infrared nano plaster of claim 1.
4, according to the described far infrared nano plaster of claim 1, the proportioning that it is characterized in that described medicine layer ointment consists of: Moschus 0.5g, Borneolum Syntheticum 1.5g, Camphora 4g, Sanguis Draxonis 2.5g, Rhizoma Et Radix Notopterygii 3.5g, Olibanum 3.5g, Myrrha 3.5g, Flos Carthami 4g, Rhizoma Chuanxiong 2g, Rhizoma Coptidis 3g, Radix Angelicae Sinensis 4g, Cinnabaris 3g, more than 12 the flavor medicines in, with Rhizoma Et Radix Notopterygii, Olibanum, Myrrha, Rhizoma Chuanxiong, Radix Angelicae Sinensis extracts volatile oil, standby, after medicinal residues dry, with Flos Carthami, Rhizoma Coptidis mixes, add 8 times of amount 80% ethanol, reflux, extract, twice each two hours, filters, merging filtrate, recovery ethanol are 1.10 extractum to relative density; Moschus, Borneolum Syntheticum, Camphora, Sanguis Draxonis, Cinnabaris are broken into the powder of 1-1000nm respectively at superfine powder under the ultralow temperature, standby; Other gets the basic cream of an amount of oil, behind the heating and melting, adds above-mentioned extractum, and fully stirring and dissolving is put after filtering, stirring and is chilled to the thick paste shape, stirs to add volatile oil and Moschus, Borneolum Syntheticum, Camphora, Sanguis Draxonis, Cinnabar down, and the mixing of milling is at last made ointment.
5,, it is characterized in that described medicine layer is positioned to mount backing layer part inner face far infrared laminar surface according to the described far infrared nano plaster of any claim among the claim 1-4.
6, according to the described far infrared nano plaster of claim 5, it is characterized in that described medicine layer is a medicine box with cover, ointment can be placed in this medicine box.
7, according to the described far infrared nano plaster of any claim among the claim 1-4, it is characterized in that the sealing coat that useful ventilative nonwoven cloth material is made between described adhesive-layer and the oxidation heating layer.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011382287A CN1156273C (en) | 2001-11-29 | 2001-11-29 | Far infrared nano plaster |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB011382287A CN1156273C (en) | 2001-11-29 | 2001-11-29 | Far infrared nano plaster |
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| Publication Number | Publication Date |
|---|---|
| CN1353984A CN1353984A (en) | 2002-06-19 |
| CN1156273C true CN1156273C (en) | 2004-07-07 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB011382287A Expired - Fee Related CN1156273C (en) | 2001-11-29 | 2001-11-29 | Far infrared nano plaster |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104510628A (en) * | 2013-09-27 | 2015-04-15 | 金红叶纸业集团有限公司 | Household paper |
| US9980539B2 (en) | 2014-08-11 | 2018-05-29 | Apple Inc. | Segmented attachment device |
| CN104826234A (en) * | 2015-05-25 | 2015-08-12 | 广西达庆生物科技有限公司 | Self-heating medical magnetic therapy infrared tepid paste and preparation method thereof |
| CN104815272A (en) * | 2015-05-26 | 2015-08-05 | 青岛海之星生物科技有限公司 | Traditional Chinese medicine plaster for treating stress incontinence and preparation method of traditional Chinese medicine plaster |
| CN106420152A (en) * | 2016-10-12 | 2017-02-22 | 李强 | Intelligent far infrared carbon nanometer health care and warm-up paster |
| CN107648530A (en) * | 2017-11-02 | 2018-02-02 | 青海喜玛拉雅药业有限公司 | Pain relieving plaster |
| CN107854586A (en) * | 2017-11-02 | 2018-03-30 | 青海喜玛拉雅药业有限公司 | Dysmenorrhea plaster |
| CN111214595A (en) * | 2020-02-27 | 2020-06-02 | 郑州爱博尔医疗设备有限公司 | Production method of hot compress wax mud block |
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2001
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| CN1353984A (en) | 2002-06-19 |
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Denomination of invention: Far infrared nano plaster Effective date of registration: 20100612 Granted publication date: 20040707 Pledgee: Wuhan East investment Company limited by guarantee Pledgor: Xu Jian Registration number: 2010990000781 |
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