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CN115175908A - 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用 - Google Patents

芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用 Download PDF

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Publication number
CN115175908A
CN115175908A CN202180008854.2A CN202180008854A CN115175908A CN 115175908 A CN115175908 A CN 115175908A CN 202180008854 A CN202180008854 A CN 202180008854A CN 115175908 A CN115175908 A CN 115175908A
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CN202180008854.2A
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CN115175908B (zh
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吕彬华
崔大为
刘连军
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Suzhou Zelgen Biopharmaceutical Co Ltd
Shanghai Zelgen Pharmatech Co Ltd
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Suzhou Zelgen Biopharmaceutical Co Ltd
Shanghai Zelgen Pharmatech Co Ltd
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Priority claimed from CN202010033277.XA external-priority patent/CN113105448A/zh
Priority claimed from CN202010534664.1A external-priority patent/CN113801113A/zh
Priority claimed from CN202011563650.9A external-priority patent/CN114671866A/zh
Application filed by Suzhou Zelgen Biopharmaceutical Co Ltd, Shanghai Zelgen Pharmatech Co Ltd filed Critical Suzhou Zelgen Biopharmaceutical Co Ltd
Publication of CN115175908A publication Critical patent/CN115175908A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用。具体地，本发明化合物具有式(I)所示结构，本发明还公开了所述化合物的制备方法及其作为KRASG12C抑制剂的用途，对KRASG12C具有很好的选择性抑制作用且具有更好的药效学、药代动力学性能和更低的毒副作用。

Description

PCT国内申请，说明书已公开。

Claims (13)

  1. PCT国内申请，权利要求书已公开。
CN202180008854.2A 2020-01-13 2021-01-12 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用 Active CN115175908B (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CN202010033277X 2020-01-13
CN202010033277.XA CN113105448A (zh) 2020-01-13 2020-01-13 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN2020105346641 2020-06-12
CN202010534664.1A CN113801113A (zh) 2020-06-12 2020-06-12 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN2020115636509 2020-12-25
CN202011563650.9A CN114671866A (zh) 2020-12-25 2020-12-25 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
PCT/CN2021/071331 WO2021143693A1 (zh) 2020-01-13 2021-01-12 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用

Publications (2)

Publication Number Publication Date
CN115175908A true CN115175908A (zh) 2022-10-11
CN115175908B CN115175908B (zh) 2024-07-23

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Country Status (4)

Country Link
US (1) US20230118795A1 (zh)
EP (1) EP4092026A4 (zh)
CN (1) CN115175908B (zh)
WO (1) WO2021143693A1 (zh)

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CN113105448A (zh) * 2020-01-13 2021-07-13 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN113801113A (zh) * 2020-06-12 2021-12-17 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN114671866A (zh) * 2020-12-25 2022-06-28 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用

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WO2022133345A1 (en) 2020-12-18 2022-06-23 Erasca, Inc. Tricyclic pyridones and pyrimidones
AR125782A1 (es) 2021-05-05 2023-08-16 Revolution Medicines Inc Inhibidores de ras
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EP4227307A1 (en) 2022-02-11 2023-08-16 Genzyme Corporation Pyrazolopyrazine compounds as shp2 inhibitors
JP2025509183A (ja) * 2022-03-04 2025-04-11 アイ－エムエービー バイオファーマ ユーエス リミテッド がんの処置のためのｋｒａｓ阻害剤を含む併用療法
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Publication number Priority date Publication date Assignee Title
CN113105448A (zh) * 2020-01-13 2021-07-13 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN113801113A (zh) * 2020-06-12 2021-12-17 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用
CN114671866A (zh) * 2020-12-25 2022-06-28 苏州泽璟生物制药股份有限公司 芳基或杂芳基并吡啶酮或嘧啶酮类衍生物及其制备方法和应用

Also Published As

Publication number Publication date
CN115175908B (zh) 2024-07-23
EP4092026A1 (en) 2022-11-23
EP4092026A4 (en) 2024-03-06
US20230118795A1 (en) 2023-04-20
WO2021143693A1 (zh) 2021-07-22

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