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CN115175906A - 一种tlr8激动剂晶型 - Google Patents

一种tlr8激动剂晶型 Download PDF

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Publication number
CN115175906A
CN115175906A CN202180015947.8A CN202180015947A CN115175906A CN 115175906 A CN115175906 A CN 115175906A CN 202180015947 A CN202180015947 A CN 202180015947A CN 115175906 A CN115175906 A CN 115175906A
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CN
China
Prior art keywords
present application
degrees
compound
mmol
tlr8
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CN202180015947.8A
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English (en)
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CN115175906B (zh
Inventor
蔡哲
孙飞
丁照中
陈曙辉
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

公开了式(I)所示的TLR8(Toll样受体8)激动剂的晶型及其制备方法，还包括所述晶型在制备治疗响应于TLR8激动的疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN202180015947.8A 2020-03-18 2021-03-18 一种tlr8激动剂晶型 Active CN115175906B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2020101934184 2020-03-18
CN202010193418 2020-03-18
PCT/CN2021/081533 WO2021185312A1 (zh) 2020-03-18 2021-03-18 一种tlr8激动剂晶型

Publications (2)

Publication Number Publication Date
CN115175906A true CN115175906A (zh) 2022-10-11
CN115175906B CN115175906B (zh) 2024-12-06

Family

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Family Applications (1)

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CN202180015947.8A Active CN115175906B (zh) 2020-03-18 2021-03-18 一种tlr8激动剂晶型

Country Status (5)

Country Link
US (1) US12516057B2 (zh)
EP (1) EP4122931B1 (zh)
CN (1) CN115175906B (zh)
ES (1) ES3036193T3 (zh)
WO (1) WO2021185312A1 (zh)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108615A (zh) * 2015-03-04 2017-08-29 吉利德科学公司 Toll样受体调节性4,6‑二氨基‑吡啶并[3,2‑D]嘧啶化合物
WO2018045150A1 (en) * 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
WO2020057604A1 (zh) * 2018-09-19 2020-03-26 正大天晴药业集团股份有限公司 Tlr8激动剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003014732A1 (en) * 2001-08-10 2003-02-20 Symyx Technologies, Inc. Apparatuses and methods for creating and testing pre-formulations and systems for same
SG11201503042QA (en) * 2012-11-16 2015-06-29 Janssen Sciences Ireland Uc Heterocyclic substituted 2-amino-quinazoline derivatives for the treatment of viral infections
CN108069963B (zh) * 2017-11-17 2020-01-14 清华大学 吡啶并嘧啶衍生物或其盐及其制法、药物组合物和用途

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107108615A (zh) * 2015-03-04 2017-08-29 吉利德科学公司 Toll样受体调节性4,6‑二氨基‑吡啶并[3,2‑D]嘧啶化合物
WO2018045150A1 (en) * 2016-09-02 2018-03-08 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
WO2020057604A1 (zh) * 2018-09-19 2020-03-26 正大天晴药业集团股份有限公司 Tlr8激动剂

Also Published As

Publication number Publication date
CN115175906B (zh) 2024-12-06
US20230303557A1 (en) 2023-09-28
ES3036193T3 (en) 2025-09-15
EP4122931A1 (en) 2023-01-25
EP4122931B1 (en) 2025-07-02
EP4122931A4 (en) 2024-04-17
US12516057B2 (en) 2026-01-06
WO2021185312A1 (zh) 2021-09-23

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