CN115166876A - Near-infrared super lens and light guide optical system for intracranial tumor thermotherapy - Google Patents
Near-infrared super lens and light guide optical system for intracranial tumor thermotherapy Download PDFInfo
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- 238000000015 thermotherapy Methods 0.000 title claims abstract description 28
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Abstract
The invention provides a near-infrared super lens and a light guide optical system for intracranial tumor thermotherapy, which comprises: a substrate that is transparent to near-infrared light; the super-surface structure units are arranged on the same surface of the substrate in an array manner, the super-surface structure units are regular hexagons and/or squares, and a nano structure is arranged at the central position of each super-surface structure unit or at the central position and the vertex position of each super-surface structure unit; the super-surface structure unit can efficiently transmit light with a near infrared wave band of 925-955nm. The light guide optical system adopts the near-infrared super lens to replace the traditional lens, and the near-infrared super lens greatly reduces the volume of the whole optical system, thereby reducing the diameter of the metal sleeve, further reducing the diameter of the required hole on the skull, and playing a good effect of relieving the pain of a patient.
Description
Technical Field
The invention relates to the field of super lenses, in particular to a near-infrared super lens and a light guide optical system for intracranial tumor thermotherapy.
Background
The blood brain barrier prevents the traditional antitumor drugs from entering the intracranial tumor through blood. Tumor thermotherapy precisely sends photothermal nanoparticles to a tumor region through a medicine delivery pipeline wrapped in a metal needle through opening of a cranium, and irradiates tumors absorbing the nanoparticles through a light guide system. The nano particles absorb infrared light and rapidly heat up to kill tumor cells. Conventional light guide systems require a conventional lens mounted on the end of the light guide waveguide to disperse the infrared light. However, the conventional lens has disadvantages of large volume, complex structure, and difficulty in integration.
Disclosure of Invention
In view of the above technical problems, embodiments of the present invention provide a near-infrared superlens and a light guiding optical system comprising the same for intracranial tumor thermotherapy.
A first aspect of an embodiment of the present invention provides a near-infrared superlens, including:
a substrate that is transparent to near-infrared light; and
the super-surface structure units are arranged on the same surface of the substrate in an array manner, each super-surface structure unit is a regular hexagon and/or a square, and a nano structure is arranged at the central position of each super-surface structure unit or at the central position and the vertex position of each super-surface structure unit; the super-surface structure unit can efficiently transmit light with a near infrared wave band of 925-955nm.
Optionally, the nano-structure is a nano-pillar structure, and the nano-pillar structure is one of a circular nano-pillar structure, a square nano-pillar structure, a round-hole nano-pillar structure and a square-hole nano-pillar structure; the nanostructures at different positions differ in optical phase at different wavelengths.
Optionally, the substrate is quartz glass, schottky glass or crown glass, and the thickness of the substrate is 0.05 to 1mm.
Optionally, the phase of the near-infrared superlens satisfies a diverging lens phase:
wherein,
the phase distribution of the diverging super lens to infrared light is shown, r is the position of the surface of the near-infrared super lens along the radius direction, lambda is in the near-infrared light with the wave band of 915-955nm, f is the focal length of the diverging super lens to the near-infrared light, and the focal length is a negative number; the phase of the near infrared super lens meets the phase distribution of the multifocal lens.
The near-infrared super lens has the advantages of simple structure, light weight, small volume and easy integration.
A second aspect of embodiments of the present invention provides a light-guiding optical system for intracranial tumor thermotherapy, comprising:
a metal sleeve;
at least one light guide waveguide, one end of which is positioned in the metal sleeve;
the near-infrared light source is positioned at the other end of the at least one light guide waveguide;
at least one near-infrared super lens as described above, disposed at one end of at least one light guide waveguide far from the near-infrared light source;
preferably, at least one turning prism is also included.
Optionally, the light guide optical system for intracranial tumor thermotherapy comprises a plurality of light guide waveguides, a plurality of near-infrared superlenses corresponding to the number of the light guide waveguides; preferably, the light guide optical system for intracranial tumor thermotherapy further comprises a plurality of turning prisms corresponding to the plurality of light guide waveguides in number, wherein one end face of each turning prism is bonded with the end face of each light guide waveguide, and the other end face of each turning prism is bonded with the near-infrared superlens.
Optionally, the metal sleeve is made of metal with good rigidity, high toughness and strong corrosion resistance; preferably, the inner diameter of the metal sleeve is 1mm-3mm, and the outer diameter is 1.2mm-3.2mm; preferably, the metal casing is a stainless steel casing, a titanium alloy casing or a nickel alloy casing.
Optionally, the near-infrared light source is a laser with a central wavelength of 940nm or a high-power LED.
Optionally, the light-guiding waveguide may conduct 925-955nm near-infrared light; the diameter of the light guide waveguide is 50-500 μm.
Optionally, the light guide optical system for intracranial tumor thermotherapy comprises a light guide waveguide and a near-infrared superlens attached to an end face of the light guide waveguide.
According to the light guide optical system for intracranial tumor thermotherapy, provided by the second aspect of the invention, the near-infrared super lens is arranged at one end of the light guide waveguide, one end of the light guide waveguide is positioned in the metal sleeve, the other end of the light guide waveguide is close to the infrared light source, and the light guide optical system is far away from the near-infrared light source.
It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the invention, as claimed.
Drawings
FIG. 1 is a schematic diagram of a near-infrared superlens structure according to an embodiment of the present invention;
FIG. 2A is a diagram of a regular hexagonal arrangement of a super-surface in one embodiment of the present invention;
FIG. 2B is a diagram illustrating a square arrangement of a super-surface in an embodiment of the present invention;
FIG. 3A is a schematic diagram of a circular nanopillar structure in an embodiment of the invention;
FIG. 3B is a schematic diagram of a circular-hole nanorod structure in an embodiment of the invention;
FIG. 3C is a schematic diagram of a square nano-pillar structure in an embodiment of the invention;
FIG. 3D is a schematic diagram of a square-hole nanorod structure, according to an embodiment of the present invention;
FIG. 4A is a graph of the phase of light at operating wavelengths of 925 nm to 955nm as a function of the diameter of a quartz substrate and a nano-pillar structure formed of amorphous silicon in accordance with an embodiment of the present invention;
FIG. 4B is a graph of the transmittance of light at a working wavelength of 925-955nm as a function of the diameter of the quartz substrate and the nano-pillar structures of amorphous silicon in accordance with an embodiment of the present invention;
FIG. 4C is a graph of the phase of light at a wavelength of 925-955nm in response to the numbering of the quartz substrate and the square nano-pillar structure of amorphous silicon in accordance with an embodiment of the present invention;
FIG. 4D is a graph of the transmittance at operating wavelengths of 925 nm to 955nm for light with respect to the numbering of the quartz substrate and the square nano-pillar structures of amorphous silicon material in accordance with an embodiment of the present invention;
FIG. 5A is a graph of negative lens radius versus phase for an operating wavelength of 940nm of 62.5 μm diameter, a focal length of-18 μm, and a divergence angle of 120 in one embodiment of the present invention;
FIG. 5B is a phase diagram of a multi-point lens with an operating wavelength of 940nm, a diameter of 62.5 μm, a focal length of 18 μm, and four focal points on the focal plane, according to an embodiment of the present invention;
FIG. 6 is a schematic view of a light-guiding optical system for intracranial tumor thermotherapy, in an embodiment of the invention;
FIG. 7A is a schematic view of a light guide system constructed by attaching the near-infrared superlens shown in FIG. 5A to a light guide waveguide having a diameter of 62.5 μm;
FIG. 7B is a schematic view of a light guide system formed by attaching the near-infrared superlens shown in FIG. 5B to a light guide waveguide having a diameter of 62.5 μm;
FIG. 7C is a schematic view of a dual optical waveguide, dual turning prism and dual near infrared formed light guide system in an embodiment of the present invention;
FIG. 8 is a graph of the relative intensity distribution at 18 μm behind the near infrared superlens for the system shown in FIG. 7A;
FIG. 9 is a graph of relative intensity distribution at the focal plane of the NIR Superlens of the system of FIG. 7B;
reference numerals:
100: a near-infrared superlens;
1: a substrate;
2: a super-surface structure unit; 21: a nanostructure; 211: a circular nanopillar structure; 212: a circular hole nano-pillar structure; 2121: a first column; 2122: a first hollow portion; 213: a square nano-pillar structure; 214: a square-hole nanocolumn structure; 2141: a fourth cylinder; 2142: a fourth hollow section;
a metal sleeve 31, a light guide waveguide 32, a near infrared light source 33, a steering prism 34 and a drug delivery pipe 35.
Detailed Description
Reference will now be made in detail to the exemplary embodiments, examples of which are illustrated in the accompanying drawings. When the following description refers to the accompanying drawings, like numbers in different drawings represent the same or similar elements unless otherwise indicated. The implementations described in the following exemplary examples do not represent all implementations consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the invention, as detailed in the appended claims.
The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used in this specification and the appended claims, the singular forms "a", "an", and "the" are intended to include the plural forms as well, unless the context clearly indicates otherwise. It should also be understood that the term "and/or" as used herein refers to and encompasses any and all possible combinations of one or more of the associated listed items.
It is to be understood that although the terms first, second, third, etc. may be used herein to describe various information, such information should not be limited by these terms. These terms are only used to distinguish one type of information from another. For example, first information may also be referred to as second information, and similarly, second information may also be referred to as first information, without departing from the scope of the present invention. The word "if," as used herein, may be interpreted as "at \8230; \8230when" or "when 8230; \823030when" or "in response to a determination," depending on the context. The features of the following examples and embodiments may be combined with each other without conflict.
The blood brain barrier prevents the traditional antitumor drugs from entering intracranial tumors through blood. Tumor thermotherapy precisely sends photothermal nanoparticles to a tumor region through a drug delivery pipeline wrapped in a metal needle head through craniocerebral opening, and irradiates the tumor absorbed with the nanoparticles through a light guide system. The nano particles absorb infrared light to rapidly increase the temperature, thereby killing tumor cells. Conventional light guide systems require a conventional lens mounted on the end of the light guide waveguide to disperse the infrared light. However, the conventional lens has disadvantages of large volume, complex structure, and difficulty in integration.
Optical super-surfaces are rapidly emerging and becoming a mainstream way to achieve miniaturized, planar optics. Optical super-surfaces have demonstrated super-surface based axicons, blazed gratings, polarizers, holographic dry plates, and planar lenses. The continuous 2 pi phase change metasurface makes a single layer aplanatic superlens a reality. At the same time, achromatic metasurfaces are also used for white light imaging.
The first embodiment is as follows:
a first aspect of an embodiment of the present invention provides a near-infrared superlens 100, including: a substrate which is transparent to near-infrared light; and a plurality of super-surface structure units arranged on the same surface of the substrate. Illustratively, referring to fig. 1, the near-infrared superlens is composed of a substrate 1 and a plurality of super-surface structure units 2 disposed on one side of the substrate 1. The plurality of super-surface structure units 2 are arranged in an array, the super-surface structure units 2 are regular hexagons and/or squares, and a nano structure 21 is arranged at the central position of each super-surface structure unit 2 or at the central position and the vertex position of each super-surface structure unit 2; the super-surface structure unit 2 can efficiently transmit light in a near-infrared band, and the near-infrared band is 925-955nm.
Optionally, the substrate 1 is quartz glass, schottky glass or crown glass, and the thickness of the substrate 1 is 0.05mm to 1mm. Illustratively, the substrate 1 is made of a first near-infrared light and second near-infrared light high-transmittance material, such as quartz glass, K9 glass, and the like. The thickness of the substrate 1 is between 0.05mm and 1mm, and the thickness may be set to 0.05mm, 0.1mm, 0.2mm, 0.3mm, 0.4mm, 0.5mm, 0.6mm, 0.7mm, 0.8mm, 0.9mm, 1mm, and so on.
For example, referring to fig. 2B, the center of each super surface structure unit 2 is respectively provided with a nano structure 21, and such an array arrangement results in the minimum number of nano structures 21 of the super surface structure unit 2 of the formed near-infrared super lens, and the performance of the formed super surface structure unit 2 also meets the requirement; illustratively, referring to fig. 2A, a nano-structure 21 is disposed at each vertex of each super-surface structure unit 2 and at each center of each super-surface structure unit 2.
For example, in some embodiments, referring to fig. 2A, all of the super surface structure units 2 are regular hexagons; in other embodiments, referring to FIG. 2B, all the units 2 of the super-surface structure are square; in other embodiments, the plurality of super surface structure units 2 includes regular hexagonal array units and square super surface structure units 2. It should be understood that in other embodiments, the super surface structure unit 2 may be designed in other close-packed or fan-shaped structures.
In this embodiment, the nanostructure 21 may have an average transmittance of greater than 80% between 915 nm and 955nm (center wavelength 940 nm).
In this embodiment, the nanostructure 21 is axisymmetrical along the first axis and the second axis, and a plurality of nanostructure units obtained by splitting the nanostructure 21 along the first axis and the second axis are the same, and such a structure is not sensitive to the polarization of incident light. Wherein the first axis and the second axis are perpendicular, and the first axis and the second axis are respectively perpendicular to the height direction of the nano structure. It should be noted that the first axis and the second axis pass through the center of the nanostructure 21 and are parallel to the horizontal plane, one straight line passing through the center of the nanostructure 21 can be arbitrarily selected as the first axis, and the other straight line passing through the center perpendicular to the first axis is the second axis.
In this embodiment, the optical phases of the nanostructures 21 at different wavelengths are different at different positions, so as to define the optical phase distribution of the super surface structure unit at different wavelengths. The overall structure formed by the plurality of nanostructures 21 according to the embodiment of the present invention can transmit near-infrared light with high transmittance.
Illustratively, the material of the nano structure 21 may be quartz glass, crystalline silicon or amorphous silicon; it should be understood that the material of the nano-pillars may be other materials.
Illustratively, the nanostructures 21 may be nano-pillar structures, or may be other nanostructures that are axisymmetric along a horizontal axis and a vertical axis, respectively.
Next, the nano-structure 21 is explained as an example of a nano-pillar structure; it should be understood that when the nano-structure 21 is other structure, the nano-pillar structure may be replaced with a corresponding structure in the following embodiments.
The nano-pillar structure may include at least one of a circular nano-pillar structure 211, a circular hole nano-pillar structure 212, a square nano-pillar structure 213, and a square hole nano-pillar structure 214. Illustratively, the nano-pillar structure is one of a circular nano-pillar structure 211, a circular-hole nano-pillar structure 212, a square nano-pillar structure 213, and a square-hole nano-pillar structure 214, which facilitates processing.
In the embodiment of the present application, the optical phase of the nano-structure, the height of the nano-pillar structure, the shape of the cross section, and the material of the nano-pillar structure.
Referring to fig. 3A to 3D, the height of the nano-pillar structure (i.e., the height of the nano-pillar structure in the z direction) is H.
The height H of the nanopillar structure is greater than or equal to 300nm and less than or equal to 3500nm, a distance between adjacent nanopillar structures (i.e., a distance between centers of two adjacent nanopillar structures) is greater than or equal to 40nm and less than or equal to 640nm, and a minimum size of the nanopillar structure and a minimum distance between two adjacent nanopillar structures (i.e., a minimum distance between edges of two adjacent nanopillars) may be 40nm. Illustratively, the height H of the nanopillar structures is 300nm, 400nm, 500nm, 600nm, 700nm, 800nm, 900nm, 1000nm, 1100nm, 1200nm, 1300nm, 1400nm, 2500nm, or 3500nm, and so forth. Illustratively, the spacing between adjacent nanopillar structures is 40nm, 140nm, 240nm, 340nm, 440nm, 540nm, or 640nm, among others.
Referring to fig. 3A, the circular nano-pillar structure 211 may include a first cylinder, which is a solid structure. The circular nanopillar structure 211 has a cross-sectional diameter d in the x-y plane in the range of 40nm to 600nm, e.g., d may be set at 40nm, 50nm, 150nm, 200nm, 250nm, 300nm, 350nm, 400nm, 500nm, 600nm, etc.
Referring to fig. 3B, the circular-hole nanorod structure 212 may include a first pillar 2121, wherein the cross-section of the first pillar 2121 has the same shape as that of the super-surface structure unit 2, for example, when the super-surface structure unit 2 is a hexagon, the cross-section of the first pillar 2121 has a hexagon shape; when the super-surface structure unit 2 is square, the shape of the cross section of the first column 2121 is also square. In this embodiment, the cross-section of the first cylinder 2121 has the same size as the super-surface structure unit 2. The first cylinder 2121 is provided with a cylindrical first hollow portion 2122 extending from the top to the bottom thereof, and the first cylinder 2121 and the first hollow portion 2122 are coaxial. The circular hole nanorod structures 212 have a cross-sectional diameter d in the x-y plane (i.e., cross-section) ranging between 40nm and 600nm, e.g., d can be set at 40nm, 50nm, 150nm, 200nm, 250nm, 300nm, 350nm, 400nm, 500nm, 600nm, etc.
Referring to fig. 3C, the square-shaped nano-pillar structure 213 may include a third pillar, the third pillar is a solid structure, and the cross section of the third pillar has a square shape.
Referring to fig. 3D, the square-hole nano-pillar structure 214 may include a fourth pillar 2141, wherein the shape of the cross section of the fourth pillar 2141 is the same as the shape of the super surface structure unit 2, for example, when the super surface structure unit 2 is a hexagon, the shape of the cross section of the fourth pillar 2141 is a hexagon; when the super surface structure unit 2 is square, the shape of the cross section of the fourth pillar 2141 is also square. In the present embodiment, the size of the cross section of the fourth pillar 2141 is the same as the size of the super surface structure unit 2. Further, the fourth pillar 2141 has a fourth hollow portion 2142 extending from the top to the bottom thereof, the cross-section of the fourth hollow portion 2142 is square, and the fourth pillar 2141 is coaxial with the fourth middle portion.
Illustratively, in certain embodiments, the nanopillar structures are circular nanopillar structures. For the design work at the near infrared wavelength of 925-955nm, the circular nano-pillar structure is made of amorphous silicon, the circular nano-pillar structure 211 adopts the circular nano-pillar structure shown in fig. 4A, the height H of the circular nano-pillar structure 211 is 600nm, and the side of the corresponding regular hexagon basic unit is 550nm. Fig. 4A shows the relationship between the optical phase of the near-infrared superlens and the diameter of the circular nanorod structures 211 at near-infrared wavelengths of 925-955nm, with the abscissa of fig. 4A being the diameter of the circular nanorod structures and the ordinate of the optical phase at 925-955nm. Fig. 4B shows the transmittance of the near infrared super lens with respect to the diameter of the circular nano-pillar structure 211 at a near infrared wavelength of 925 to 955nm, and in fig. 4B, the abscissa is the diameter of the circular nano-pillar structure 211 and the ordinate is the optical phase at 925 to 955nm. FIG. 4C shows the relationship between the optical phase of the near infrared superlens and the number of the square nanorod structures 213 at a near infrared wavelength of 925-955nm, and in FIG. 4C, the abscissa is the number of the square nanorod structures 213 and the ordinate is the optical phase at 925-955nm. FIG. 4D shows the transmittance of the near infrared superlens at a near infrared wavelength of 925-955nm as a function of the number of the square nanorod structures 213, and FIG. 4D shows the optical phase at 925-955nm with the abscissa representing the number of the square nanorod structures 213.
Illustratively, the phase of the near-infrared superlens satisfies the diverging lens phase:
wherein,
in order to obtain the phase distribution of the diverging superlens to the infrared light, r is the position of the surface of the near-infrared superlens along the radial direction, λ is in the range of 915-955nm of the near-infrared light, and f is the focal distance (the focal distance is negative) of the diverging superlens to the near-infrared light. Referring to FIG. 5A, in some embodiments, the near infrared superlens surface radius at 940nm is 62.5 μm, the focal length is-18 μm, and the divergence angle is 120 ° as a function of phase.
Illustratively, the phase of the near infrared superlens satisfies a multifocal lens phase profile, which can be obtained by an optimization algorithm. Referring to FIG. 5B, in some embodiments, the working wavelength at 940nm is 62.5 μm in diameter, the focal length is 18 μm, and the phase diagram of the near-infrared lens surface with four focal points on the focal plane is shown.
The second embodiment:
a second aspect of the embodiments of the present invention provides a light guiding optical system for intracranial tumor thermotherapy, please refer to fig. 6, including:
a metal sleeve 31;
at least one light guide waveguide 32, one end of which is located inside the metal sleeve 31;
a near-infrared light source 33 located at the other end of at least one of the light guide waveguides 32;
at least one near-infrared superlens 100 as described above is disposed at an end of at least one of the light guide waveguides 32 away from the near-infrared light source 33.
The light guide optical system for intracranial tumor thermotherapy based on the near-infrared superlens 100 of the invention uses the near-infrared superlens 100 to replace a traditional lens, so the light guide optical system for intracranial tumor thermotherapy has the advantages of simple structure, light weight, small volume and easy integration. In addition, the size of the whole optical system is greatly reduced by the near-infrared super lens 100, so that the diameter of the metal sleeve 31 is reduced, the diameter of the hole on the skull is reduced, and the pain of a patient is relieved.
As a preferred embodiment of the invention, the light guide optical system for intracranial tumor thermotherapy comprises a plurality of light guide waveguides 32, a plurality of near-infrared superlenses 100 corresponding to the number of the light guide waveguides 32; as shown in fig. 7C, the light guide optical system for intracranial tumor thermotherapy further includes a plurality of turning prisms 34 corresponding to the number of the light guide waveguides 32, wherein one end surface of the turning prism 34 is bonded to the end surface of the light guide waveguide 32, and the other end surface of the turning prism 34 is bonded to the near-infrared superlens 100. One side of the light guide waveguide 32 is provided with a drug delivery tube 35. When a plurality of the light guide waveguides 32 and a plurality of the turning prisms 34 are included, the light guide optical system for intracranial tumor thermotherapy can be ensured to cover the full space angle more completely.
The metal sleeve 31 is made of metal with good rigidity, high toughness and strong corrosion resistance; preferably, the metal sleeve can be made of stainless steel, the inner diameter of the metal sleeve is 1mm-3mm, and the outer diameter of the metal sleeve is 1.2mm-3.2mm; in this embodiment, the metal sleeve 31 is preferably a stainless steel sleeve, a titanium alloy sleeve, or a nickel alloy sleeve.
Optionally, the near infrared light source 33 is a laser with a center wavelength of 940nm or a high-power LED. Illustratively, the output optical power of the laser with the central wavelength of 940nm is adjustable and is from 0 to 10000mW; the half divergence angle is less than 2 degrees, and the light polarization state is circular polarization. Illustratively, an LED light source with a center wavelength of 940nm has a half divergence angle of less than 10, a spectral width of 30nm, and an output optical power of 5W. The near-infrared light source 33 may be only one, and when the light guide waveguide 32 is plural, the near-infrared light source 33 is divided into plural beams by the light guide waveguide 32.
Optionally, the light-guiding waveguide may conduct 925-955nm near-infrared light; the diameter of the light guide waveguide is 50-500 μm. Preferably, the light guide waveguide 32 is one of a single mode fiber, a multimode fiber, and a photonic crystal fiber.
As another preferred embodiment of the present invention, the light guide optical system for intracranial tumor thermotherapy may also include a light guide waveguide 32 and a near-infrared superlens 100 attached to the end face of the light guide waveguide 32. Therefore, the structure of the near-infrared super lens 100 is simpler, the process is mature, the reliability is high, and the integration is easier.
For example, please refer to fig. 7A and 7B, wherein fig. 7A is a schematic diagram of a light guide system formed by attaching the near-infrared super-lens shown in fig. 5A to a light guide waveguide with a diameter of 62.5 μm; wherein, fig. 7B is a schematic diagram of a light guide system formed by attaching the near-infrared superlens shown in fig. 5B to a light guide waveguide with a diameter of 62.5 μm.
For example, please refer to fig. 7C, wherein fig. 7C is a schematic diagram of a light guide system consisting of a dual light waveguide, a dual turning prism and dual near infrared rays. The two turning prisms respectively guide the light to two opposite half spaces, and the light is diffused by the two near-infrared super lenses 100 to cover the full space in the largest range.
Illustratively, referring to FIG. 8, FIG. 8 is a graph of the relative intensity distribution of the system shown in FIG. 7A at 18 μm behind the NIR microlens (reference plane). Wherein the on-axis light intensity on the reference plane is highest and the edge point is lowest.
Illustratively, referring to fig. 9, fig. 9 is a diagram of the relative intensity distribution of the system shown in fig. 7B in the focal plane of the near-infrared superlens. Wherein, four focuses are symmetrically distributed on the focal plane.
The above examples are only intended to illustrate the technical solution of the present invention, and not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.
Claims (10)
1. A near-infrared superlens, comprising:
a substrate that is transparent to near-infrared light; and
the super-surface structure units are arranged on the same surface of the substrate in an array manner, the super-surface structure units are regular hexagons and/or squares, and a nano structure is arranged at the central position of each super-surface structure unit or at the central position and the vertex position of each super-surface structure unit; the super surface structure unit can efficiently transmit light with a near infrared band of 925-955nm.
2. The near-infrared superlens of claim 1, wherein the nano-structures are nano-pillar structures, the nano-pillar structures being one of circular nano-pillar structures, square nano-pillar structures, round hole nano-pillar structures, and square hole nano-pillar structures; the nanostructures at different positions differ in optical phase at different wavelengths.
3. The near-infrared superlens of claim 1, wherein the substrate is quartz glass, schottky glass or crown glass, and the thickness of the substrate is 0.05-1mm.
4. The near-infrared superlens of claim 1, wherein the phase of the near-infrared superlens satisfies the diverging lens phase:
wherein,
the phase distribution of the diverging super lens to infrared light is shown, r is the position of the surface of the near-infrared super lens along the radius direction, lambda is in the near-infrared light with the wave band of 915-955nm, f is the focal length of the diverging super lens to the near-infrared light, and the focal length is a negative number; the phase of the near infrared super lens meets the phase distribution of the multifocal lens.
5. A light-guiding optical system for thermotherapy of intracranial tumors, comprising:
a metal sleeve;
at least one light guide waveguide, one end of which is positioned in the metal sleeve;
the near-infrared light source is positioned at the other end of the at least one light guide waveguide;
at least one near-infrared superlens of any one of claims 1-4 disposed at an end of at least one of the light-guiding waveguides remote from the near-infrared light source;
preferably, at least one turning prism is further included.
6. A light-guiding optical system for intracranial tumor thermotherapy according to claim 5, comprising a plurality of light-guiding waveguides, a plurality of near-infrared superlenses according to any one of claims 1 to 4 corresponding to the number of light-guiding waveguides; preferably, the light guide optical system for intracranial tumor thermotherapy further comprises a plurality of turning prisms corresponding to the plurality of light guide waveguides in number, wherein one end face of each turning prism is bonded with the end face of each light guide waveguide, and the other end face of each turning prism is bonded with the near-infrared superlens.
7. The light-guide optical system for intracranial tumor thermotherapy according to claim 5, wherein the metal sleeve is made of a metal with high rigidity, high toughness and high corrosion resistance; preferably, the inner diameter of the metal sleeve is 1mm-3mm, and the outer diameter is 1.2mm-3.2mm; preferably, the metal sleeve is a stainless steel sleeve, a titanium alloy sleeve or a nickel alloy sleeve.
8. A light-guiding optical system for intracranial tumor thermotherapy according to claim 5, wherein the near-infrared light source is a laser or a high-power LED having a central wavelength of 940 nm.
9. The light-guiding optical system for intracranial tumor thermotherapy according to claim 5, wherein the light-guiding waveguide is capable of conducting 925-955nm near-infrared light; the diameter of the light guide waveguide is 50-500 μm.
10. A light-guiding optical system for intracranial tumor thermotherapy according to claim 5, wherein the light-guiding optical system for intracranial tumor thermotherapy comprises a light-guiding waveguide and a near-infrared superlens according to any one of claims 1 to 4 attached to an end face of the light-guiding waveguide.
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