CN115006296A - A kind of breath-removing composition and application in oral care products - Google Patents

Abstract

The invention discloses a breath-removing composition and its application in oral care products, belonging to the technical field of oral care. The breath-removing composition comprises biological zinc-yeast/zinc fermentation products, and the content of the biological zinc in the oral care product is 0.1%-10%. The yeast/zinc fermented product was used for the first time in oral care products with breath-removing function. While adsorbing sulfide in breath, it solved the problems of low solubility of conventional organic zinc and strong astringency of inorganic zinc ions. The obtained product can inhibit sulfide in the breath for a long time, refresh the breath without obvious astringency or astringency of the oral mucosa.

Description

A kind of breath-removing composition and application in oral care products

technical field

The invention relates to the technical field of oral care, in particular to a breath removing composition and its application in oral care products.

Background technique

Bad breath, also known as bad breath, refers to a symptom of an unpleasant odor when breathing or opening the mouth. Bad breath is fairly common among adults, and epidemiological surveys have shown a higher incidence of bad breath. Halitosis is divided into Genuine Halitosis, Pseudo Halitosis and Halitophobia. True halitosis is a distinct odor from the mouth that others can perceive. True halitosis is divided into physiological halitosis (Physiologic Halitosis) and pathological halitosis (Pathologic Halitosis). Physiological halitosis arises from the decay process of the oral cavity, and no specific diseases or pathological conditions exist that can cause halitosis. The main source of bad breath is the back of the tongue. Temporary bad breath caused by food factors (garlic, onions, etc.) also falls into this category. Pathological halitosis is divided into oral halitosis and non-oral halitosis. Oral halitosis is caused by poor oral hygiene or certain oral diseases, such as periodontal disease, uncured caries, xerostomia, etc. Non-oral halitosis is halitosis caused by diseases of the nasal cavity, throat, lungs or upper digestive system and systemic diseases such as uremia and liver cirrhosis. False halitosis refers to the patient's self-perceived oral odor, and the test result is negative. This symptom can be improved through explanation and psychological counseling. Odorphobia refers to the fact that after the treatment of real or false halitosis, the patient still insists that he has bad breath, and there is no factor that can cause bad breath after examination.

The causes of bad breath include intraoral factors, extraoral factors and psychological factors. Among the three factors, oral factors were the main pathogenic factors. Studies have shown that 87% of the causative factors of halitosis patients come from the oral cavity (Delanghe G, Ghyselen J, Bollen C, et al. An inventory of patients'response to treatment at amulti-disciplinary breath odor clinic[J].Quintessence Int , 1999, 30:307-310.). In addition, certain psychiatric and systemic diseases can also cause bad breath.

According to statistics, 80%-90% of bad breath originates from the oral cavity, such as caries, periodontal disease, tongue coating, food impaction, poor restorations, oral mucosal diseases, etc. Among them, dental caries and periodontal disease are the most common related diseases. The oral cavity contains a large number of microorganisms, which catabolize and metabolize food residues such as amino acids and proteins remaining in the oral cavity to produce unpleasant odors—Volatile sulfur compounds (VSCs). The main components of sulfide are hydrogen sulfide, methyl mercaptan and ethyl sulfide (Scully C, el-Maaytah M, Porter SR, et al. Breath odor: etippatheogenesis, assessment and management [J]. Eur J Oral Sci, 1997, 105:287-293). Clinical experiments have shown that the level of VSCs is positively correlated with the degree of bad breath (NakanoY, Yoshimura M, KogaT.Correlation between oral malodor and periodontal bacteria[J].MicrobesInfect,2002,4(6):67).

At present, most studies believe that the microorganisms (mainly Gram-negative anaerobic bacteria) that cause bad breath in the oral cavity are mainly concentrated in the gingival sulcus (periodontal pocket) and tongue coating (Tonzetich J, McBride B C. Characterization of volatilesulphur production by pathogenic and non -pathogenic strains of oral Bacteroides [J]. Arch Oral Biol, 1981, 26: 963–969). This is consistent with research reports (Liu Binghong. Classification of halitosis and analysis of related etiologies [J]. Continuing Medical Education, 2007, 34: 72-74) the oral sources of VSCs are mainly the gingival sulcus (periodontal pocket) and the back of the tongue. of.

The patent "Zinc Citrate Pellets in Oral Composition" (ZL 03809346) uses zinc citrate as an anti-tartar substance to be added to the oral composition, and the addition amount of zinc salt is 0.001%-20%. The patent "An efficient stain removal and whitening toothpaste and its manufacturing method" (ZL 200510026049.5) mentions the proportion of a whitening toothpaste, zinc citrate is 0.5%-3.5%, this patent believes that zinc citrate can dissolve calculus and Inhibits plaque calcification deposition, thereby preventing the formation of plaque and calculus. The patent "Toothpaste Containing Calcium Carbonate and Zinc Citrate" (ZL 200580026141.X) mentions that a toothpaste composition contains zinc salt, which exists in the form of zinc citrate dissolved in water, and zinc citrate acts as an anti-oxidant. Stone agent. The patent "Production Method of Attapulgite Double Fluoride Toothpaste" (ZL 200810018916.4), the attapulgite double fluoride toothpaste contains zinc citrate, and the addition amount is 0.05%-1.0%. The function of zinc citrate is to prevent the formation of calculus and inhibit smoke spots , the adhesion of pigments such as tea spots on the tooth surface. The patent "Production method of attapulgite toothpaste for removing smoke stains" (ZL 200810018908.X) mentions that the addition amount and function of zinc citrate are the same as the previous patent. The toothpaste described in the patent "Drug toothpaste for treating oral diseases and its preparation method" (ZL201010135299.3) contains zinc citrate in an addition amount of 0.5%-2%, but its function is not mentioned. The toothpaste described in the patent "A toothpaste for removing bad breath and preventing oral ulcers" (ZL 20101047150.7) contains zinc citrate in an amount of 1%-2%. This invention considers adding naringin, zinc citrate, Eucalyptol and other ingredients can remove bad breath and kill harmful bacteria in the mouth. Zinc citrate has the effect of removing bad breath, preventing gingivitis, calculus, and bleeding teeth. The patent "Dentifrice Containing Stannous Fluoride Plus Zinc Citrate and Low Levels of Water" (ZL 200980162304.5) describes the dentifrice containing a source of zinc ions, including zinc salts of organic acids, including zinc citrate. The toothpaste described in the patent "Oral Care Composition" (ZL201180018204.2) contains a citrate ion source which is slightly water-soluble citrate, and the citrate is zinc citrate. The citrate ion source accounts for at least 0.6% of the total formula. Zinc citrate was chosen to provide an additional opacifying effect to further improve the aesthetics of the product. This patent believes that zinc ions are also valuable for the antiplaque and antitartar properties of the composition. The composition described in the patent "Oral Care Composition" (ZL 201180018162.2) contains one or more zinc ion sources, and the zinc ion source is zinc citrate, which helps to increase the aesthetics and stability of the product. In the patent "Oral Care Composition Containing Quinones and Other Antimicrobial Agents" (ZL 201080070593.9), the antimicrobial agent of the composition contains zinc-containing compounds, and zinc citrate is one of them. The patent "Taste-masked Oral Care Composition" (ZL 201180067627.3), the composition contains a series of fragrance ingredients for masking oral odor, which contains a metal salt, and the metal salt is zinc citrate. There are many reports on the application of zinc citrate as the adsorption of sulfide in the oral cavity. However, due to the low solubility of zinc citrate, it is difficult to achieve an effective concentration, and a certain concentration of zinc ions will bring obvious astringency and astringency in the oral cavity, which limits the Its practical application in oral care products.

At present, yeast/zinc fermentation products are mainly used as cosmetics, and there is no research on their use as a deodorant.

SUMMARY OF THE INVENTION

In view of the defects in the prior art, the present invention provides a breath-removing composition and its application in oral care products. The yeast/zinc fermented product is applied to the oral care product with breath-removing function for the first time. At the same time, the problems of low solubility of conventional organic zinc and strong convergence of inorganic zinc ions are solved.

The breath removing composition provided by the present invention includes biological zinc, and its content in oral care products is 0.1%-10% by weight; the biological zinc is a yeast/fermentation product.

The combined species of yeast/zinc fermentation product is prepared by fermentation of Saccharomyces cerevisiae. During the yeast fermentation process, zinc and amino acids, polypeptides and other highly active small molecular substances exist in the form of chelation, so that inorganic zinc is converted into organic zinc, reducing the amount of zinc. The skin irritation characteristic of inorganic zinc makes it more suitable for oral care product applications.

Preferably, it also includes organic zinc or inorganic zinc, including organic zinc or inorganic zinc, and the weight ratio of the biological zinc to the organic zinc/inorganic zinc is 100:1-5:1; the organic zinc includes zinc citrate, acetic acid Any one or more of zinc and zinc gluconate, and the inorganic zinc includes any one or more of zinc chloride or zinc sulfate.

Preferably, the weight ratio of the biological zinc to the organic zinc/inorganic zinc is 10:1.

Zinc citrate (organic zinc) can be used as an antibacterial substance in the composition on the one hand, which can effectively inhibit the growth of volatile sulfide-producing bacteria in the oral cavity, and on the other hand, it can also provide zinc ions that react with sulfides.

An application of the above breath-removing composition in an oral care product, the oral care product includes any one of toothpaste, tooth powder, mouthwash, and mouth freshener.

Preferably, the weight percent content of biological zinc in the oral care product in the breath-removing composition is 0.1-10%; the weight percent content of organic zinc or inorganic zinc in the oral care product in the breath-removing composition 0.01-2%. It should be noted that there are many types of organic zinc or inorganic zinc to choose from, and the solubility is different, and the added content should be based on complete dissolution.

A mouthwash, by weight percentage, comprising: 0.1%-12% of the above-mentioned breath removing composition, 15%-25% of sorbitol, 5%-15% of glycerin, 4%-6% of propylene glycol, poloxamer 407 0.5%-1.5%, essence 0.08%-0.12%, sodium saccharin 0.01-0.03%, cetylpyridinium chloride 0.04-0.06%, and the balance is water.

Preferably, in parts by weight, it comprises: 0.1%-10% of the breath-removing composition according to any one of claims 1-2, 15%-25% of sorbitol, 5%-15% of glycerol, 4% of propylene glycol- 6%, Poloxamer 407 0.5%-1.5%, essence 0.08%-0.12%, sodium saccharin 0.01-0.03%, cetylpyridinium chloride 0.04-0.06%, and the balance is water.

A preparation method of the above-mentioned mouthwash, comprising the following steps:

(1) Poloxamer 407 is added to deionized water by weight percentage, stirred to dissolve completely; Add sodium saccharin, cetyl pyridinium chloride, the above-mentioned breath-removing composition, stir to dissolve completely; Add sorbitol, glycerin, stir Evenly, stir to make the water phase;

(2) adding essence into propylene glycol and stirring to make oil phase;

(3) Under stirring conditions, add the oil phase to the water phase, and stir for 20-30min to obtain the result.

The technical scheme of the present invention has the following advantages:

It is the first time that yeast/zinc fermentation products are used in oral care products with breath-removing function. At the same time of adsorbing sulfide in breath, it also solves the problems of low solubility of conventional organic zinc and strong astringency of inorganic zinc ions.

The yeast/zinc fermentation product is compounded with other organic zinc or inorganic zinc to synergistically enhance the absorption efficiency of sulfide in the breath, while providing a good product taste. The obtained product can inhibit sulfide in the breath for a long time, refresh the breath without obvious astringency or astringency of the oral mucosa.

Detailed ways

The technical solutions of the present invention will be described clearly and completely below. Obviously, the described embodiments are part of the embodiments of the present invention, but not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

The yeast/zinc fermentation product involved in the present invention, INCI name: yeast/zinc fermentation product, has been included in the "Catalogue of Cosmetic Raw Materials Used" (version 2021).

The other reagents involved in the present invention are common commercial products unless otherwise specified.

Examples 1-5

The embodiment is designed according to the formula in Table 1.

Table 1

Comparative Examples 1-6 The formulations of the comparative examples are shown in Table 2.

Table 2

Preparation process: The preparation process of each embodiment and comparative example in Table 1 and Table 2 adopts the following scheme, and the corresponding addition step is omitted in the embodiment without added components. (1) Poloxamer 407 was added to deionized water, stirred until completely dissolved; added sodium saccharin, cetyl pyridinium chloride, yeast/zinc fermented product, zinc citrate, stirred until completely dissolved; added sorbitol, glycerin, stirred Evenly, stir for 5min to make water phase; (2) add essence into propylene glycol and stir to make oil phase; (3) under stirring condition, add oil phase to water phase and stir for 20min.

Performance testing

1. In vitro breath removal efficacy test - the effect of adsorbing volatile sulfide (hydrogen sulfide) in the breath

1.1 Test method

Take 9 mL of the mouthwash in each of the examples and the comparative example and put them into a 22-mL headspace injection bottle. The blank control group is 9 mL of deionized water. The syringe draws 1 mL of the standard sample of hydrogen sulfide aqueous solution, and it is injected into the headspace injection bottle and quickly capped. The hydrogen sulfide content was detected by gas chromatograph with FPD+ detector combined with headspace sampler equipment, and the hydrogen sulfide peak area was recorded. The hydrogen sulfide content in each group of samples was calculated according to the hydrogen sulfide standard curve, and the control group was an aqueous solution.

1.2 Test results

Calculate the hydrogen sulfide absorption rate of each group of samples according to the following formula: absorption rate (%) = [(Hydrogen sulfide content in blank control group - hydrogen sulfide content in experimental group) / hydrogen sulfide content in blank control group] × 100

Table 3 in vitro test samples of each embodiment to hydrogen sulfide absorption rate

Hydrogen sulfide absorption rate (%) Example 1 96 Example 2 97 Example 3 98 Example 4 97 Example 5 99 Comparative Example 1 3 Comparative Example 2 13 Comparative Example 3 54 Comparative Example 4 66 Comparative Example 5 99 Comparative Example 6 15 control group 0

It can be seen from the results in Table 2 that the combination of biological zinc and organic zinc or inorganic zinc in the examples has a synergistic effect and has a high absorption rate for hydrogen sulfide. Comparative example 2 only adds zinc citrate, which has a limited effect on hydrogen sulfide absorption under limited solubility; yeast/zinc fermentation products are added in comparative examples 3-4, which have a significant hydrogen sulfide absorption effect; The hydrogen sulfide absorption effect of the proportion 5 is better, but it brings obvious astringency and astringency under the effective addition amount, which limits its application in oral care products; the addition amount of biological zinc and organic zinc in the comparative example 6 is less, The ratio is 1:1, and the absorption effect is also poor. The reason may be that the zinc ion activity in the form of organic zinc is not fully released, thus affecting the synergistic effect of the combination of the two.

2. Efficacy test of removing sulfide in human breath

2.1 Test method

The subjects were men and women with oral halitosis who met the inclusion and exclusion criteria. After collecting saliva, the hydrogen sulfide content in the saliva was tested to obtain the baseline value of breath. In the morning of the test, people did not eat or brush their teeth, collect 10 mL of saliva to detect the hydrogen sulfide content by gas chromatography, gargle the test sample for 30 seconds and spit it out, and then take 10 mL of saliva within 10 minutes, and use gas chromatography to test the hydrogen sulfide content in the saliva after gargling. Each subject used one sample per day, and tested continuously for 5 days until 5 samples were tested.

2.2 Test results

The removal rate of hydrogen sulfide in the breath is calculated as follows: removal rate (%) = [(hydrogen sulfide content before rinsing - hydrogen sulfide content after rinsing) / hydrogen sulfide content before rinsing] × 100

Table 4 Removal rate of hydrogen sulfide in breath after mouthwash

It can be seen from the results in Table 4 that there is no obvious breath removal effect when using the mouthwash of the sample of Comparative Example 1, and the hydrogen sulfide removal rate is less than 10%. The active ingredient in Comparative Example 2 only added yeast/zinc extract, and the hydrogen sulfide removal rate was also poor. The combined yeast/zinc extract and zinc citrate mouthwashes of Examples 1 and 2 had a significant effect of removing hydrogen sulfide from breath. It shows that the two have a synergistic effect.

3. Taste test

3.1 Test method

20 volunteers were recruited to perform the mouthwash test of the samples of the example and the comparative example, and filled out a questionnaire for scoring. The scoring standard is set as: 5 points - no discomfort, no astringency, no convergence; 4 points - no obvious discomfort, no obvious astringency or convergence; 3 points - fair, with perceptible astringency or convergence; 2 Score - obvious discomfort, obvious involvement or convergence; 1 - very discomfort, strong involvement or convergence.

3.2 Test results

The mouthfeel scores of each embodiment were counted, and the results were averaged, and the data were shown in Table 5.

Table 5 Mouthwash mouthfeel test score of each embodiment sample

As can be seen from the results in Table 5, the mouthwash samples to which the yeast/zinc fermented product was added had no astringency or astringency, and had good mouth usability.

Obviously, the above-mentioned specific embodiments are only examples for clear description, rather than limiting the embodiments. For those of ordinary skill in the art, changes or modifications in other different forms can also be made on the basis of the above description. There is no need and cannot be exhaustive of all implementations here. And the obvious changes or changes derived from this are still within the protection scope of the present invention.

Claims (7)

1. A breath-removing composition is characterized by comprising biological zinc, wherein the biological zinc is a yeast/zinc fermentation product and is contained in an oral care product in an amount of 0.1-10% by weight.

2. The breath-removing composition according to claim 1, further comprising organic zinc or inorganic zinc, wherein the weight ratio of biological zinc to organic zinc/inorganic zinc is 100:1 to 5: 1; the organic zinc comprises any one or more of zinc citrate, zinc acetate and zinc gluconate, and the inorganic zinc comprises any one or more of zinc chloride and zinc sulfate.

3. A breath-removing composition according to claim 2, wherein the weight ratio of biological zinc to organic or inorganic zinc is 10: 1.

4. Use of a breath-freshening composition according to any one of claims 1 to 3 in an oral care product comprising any one of a toothpaste, a tooth powder, a mouthwash, a breath freshening.

5. A mouthwash, characterized by comprising, in weight percent: a breath-removing composition according to any one of claims 1 to 3 comprising 0.1% to 12%, sorbitol 15% to 25%, glycerin 5% to 15%, propylene glycol 4% to 6%, poloxamer 4070.5% to 1.5%, essence 0.08% to 0.12%, sodium saccharin 0.01% to 0.03%, cetylpyridinium chloride 0.04% to 0.06%, and balance water.

6. The mouthwash according to claim 5, comprising the following components in parts by weight: a breath-removing composition according to any one of claims 1 to 3 comprising 0.1% to 10%, sorbitol 15% to 25%, glycerin 5% to 15%, propylene glycol 4% to 6%, poloxamer 4070.5% to 1.5%, essence 0.08% to 0.12%, sodium saccharin 0.01% to 0.03%, cetylpyridinium chloride 0.04% to 0.06%, and balance water.

7. A process for preparing a mouthwash according to any of claims 5 to 6, comprising the following steps:

(1) adding the poloxamer 407 into deionized water according to the weight percentage, and stirring until the poloxamer is completely dissolved; adding saccharin sodium, cetylpyridinium chloride, the breath-removing composition of any of claims 1-3, and stirring until completely dissolved; adding sorbitol and glycerol, stirring, and making into water phase;

(2) adding essence into propylene glycol, and stirring to obtain oil phase;

(3) adding the oil phase into the water phase under stirring, and stirring for 20-30 min.