CN114917406A - A nanotube capable of promoting self-selective neural repair - Google Patents

Abstract

The invention relates to a nanotube capable of promoting self-selective nerve repair, comprising a hollow nanotube body and a slidable cover plate. The sidewall of the nanotube body is provided with a sidewall opening; the interior of the nanotube body is provided with a hollow The cavity, the hollow cavity is used to contain the nerve structure that is not completely broken and/or the nerve sheath is not wrapped around the exposed nerve; the slidable cover is arranged on one side of the side wall opening; The other side is provided with a cover plate lock; the slidable cover plate can be slidably switched between the first position and the second position; when the slidable cover plate is in the first position, the slidable cover plate opens the side wall opening; When the slidable cover plate is in the second position, the slidable cover plate is engaged with the cover plate lock, the slidable cover plate is fastened by the cover plate lock, and the slidable cover plate closes the side wall opening.

Description

A nanotube capable of promoting self-selective neural repair

technical field

The invention relates to the technical field of medical supplies and consumables, in particular to a nanotube capable of promoting self-selective nerve repair.

Background technique

For patients with multiple or huge cysts in the sacral canal, whether it is inside the cyst or the nerves around the cyst, after long-term compression, the nerve function is on the verge of collapse, and some nerves lose their proper cylindrical shape and merge with the cyst wall. Membrane. Any minor micromanipulation sexual harassment may result in loss of neurological function or impairment, and the result is disabling.

With the development of human civilization of upright walking and the accelerated pace of urbanization, sedentary, standing and walking work postures have become increasingly normalized, and the incidence of sacral cysts and sacral lesions has increased year by year. Many patients will face potential damage to the nerves in the sacral canal, and concomitant occult neurological dysfunction, or fecal dysfunction. The treatment for this kind of unspeakable has become more and more urgent in the society. The potential social benefits that can be brought about by improving this kind of neurological dysfunction are huge, and the market potential is also broad.

In the prior art, the Chinese invention patent with publication number CN101766836A discloses a preparation method of nano-silver spinal cord and peripheral nerve repair material, which uses tissue engineering methods to repair human or animal spinal cord and peripheral nerve injuries. The repair material is made of collagen (types I, III, IV), chitosan and nano-silver, and is characterized by closed ends.

The Chinese invention patent publication number CN106188583A discloses a sericin conductive hydrogel, a preparation method thereof, and a stent prepared by the sericin conductive hydrogel. The sericin conductive hydrogel is cross-linked by sericin. It is transplanted into the body in a minimally invasive way, which minimizes the trauma and pain caused by the transplant operation, and does not produce a serious immune response after implantation in the body.

However, most of these technical solutions in the prior art are based on an alternative continuous nerve repair mode, which is aimed at the loss or rupture of a certain segment of the nerve. Nano-silver or hydrogel links the two broken ends of the nerve, and then the nano-silver or hydrogel connects the two ends of the nerve rupture. Silver or hydrogel forms a nerve-like structure, and it is hoped that it can function as a nerve conduction, which is a repair of compensatory properties.

The present application is based on the nerve structure that is not completely broken, but the nerve has been damaged and cannot perform the normal nerve conduction function, and it plays a real repair and repair role.

SUMMARY OF THE INVENTION

The present invention aims to provide a nanotube capable of promoting self-selective nerve repair, and the technical problem to be solved is how to assist the self-repair of damaged nerves.

The purpose of the present invention is to solve the deficiencies of the prior art and provide a nanotube capable of promoting self-selective nerve repair, including a hollow nanotube body and a slidable cover plate, the sidewall of the nanotube body is provided with a side wall a wall opening, the sidewall opening extends along the length direction of the nanotube body; a hollow cavity is arranged inside the nanotube body, and the hollow cavity is used to contain the incomplete Broken nerve structure and/or no nerve sheath to wrap the exposed nerve; the slidable cover plate is provided on one side of the side wall opening; the other side of the side wall opening is provided with a cover plate lock; the slidable cover can be slidably switched between the first position and the second position; when the slidable cover is in the first position, the slidable cover The wall opening is opened; when the slidable cover is in the second position, the slidable cover is engaged with the cover lock, and the slidable cover is locked by the cover lock The cover plate is fastened, and the slidable cover plate closes the side wall opening.

The nanotube body is a long cylindrical structure with partial openings.

The length of the nanotube body can be extended.

The length of the nanotube body is 2cm, 4cm or 6cm, the inner diameter of the nanotube body is 2mm, 4mm, 6mm or 8mm, and the nanotube bodies with different inner diameters are suitable for accommodating different numbers of damaged nerves.

Preferably, the inside of the nanotube body is pre-laid with slow-release nerve regeneration stimulating factor.

Preferably, the nanotubes capable of promoting self-selective neural repair are capable of self-degrading within 3 years.

Further preferably, the width of the sidewall opening set on the nanotube body with an inner diameter of 4mm is 1.5mm; the width of the sidewall opening set on the nanotube body with an inner diameter of 6mm is 2.5mm; the inner diameter of the nanotube with an inner diameter of 8mm is 2.5mm. The width of the side wall opening provided in the main body is 3.5 mm.

Preferably, the nanotubes capable of promoting self-selective nerve repair are made of chitosan nanomaterials.

Preferably, the wall thickness of the nanotube body is 1 mm.

Preferably, the cover plate locks are set at intervals of 1.9 cm along the length direction of the nanotube body, and the number of the cover plate locks provided on the nanotube bodies with different lengths varies.

beneficial effect

Compared with the prior art, the beneficial effects of the present invention are:

(1) The nanotubes capable of promoting self-selective nerve repair according to the present invention are open but can be closed in one-way locking;

(2) The nanotubes capable of promoting self-selective nerve repair according to the present invention can contain damaged nerves;

(3) The nanotubes of the present invention can promote the self-selection of damaged nerves to repair their own missing nerve structures and functions;

(4) The nanotube capable of promoting self-selective nerve repair described in the present invention is not a substitute material for broken nerves, but a protective device for assisting the self-repair of damaged nerves.

Description of drawings

The accompanying drawings are used to provide a further understanding of the technical solutions of the present invention, and constitute a part of the specification. They are used to explain the technical solutions of the present invention together with the specific embodiments of the present application, and do not limit the technical solutions of the present invention.

FIG. 1 is a schematic view of the appearance of the nanotubes capable of promoting self-selective nerve repair according to the present invention when placed horizontally.

Figure 2 is a cross-sectional view of a nanotube capable of promoting self-selective nerve repair according to the present invention.

3 is a schematic view of the appearance of the nanotubes capable of promoting self-selective nerve repair according to the present invention when they are placed vertically.

4 is a cross-sectional view of another embodiment of a nanotube capable of promoting self-selective neural repair according to the present invention.

Detailed ways

The present invention is described in more detail below to facilitate understanding of the present invention.

As shown in FIG. 1 to FIG. 3 , the nanotube capable of promoting self-selective nerve repair according to the present invention includes a hollow nanotube body 1 and a slidable cover plate 2 , and a side wall of the nanotube body 1 is provided with The sidewall opening 5, the sidewall opening 5 extends along the length direction of the nanotube body 1; the nanotube body 1 is provided with a hollow cavity inside, and the hollow cavity is used to contain The slidable cover plate 2 is arranged on one side of the side wall opening 5; the side wall opening 5 The other side of the cover is provided with a cover plate lock 6; the slidable cover plate 2 can be slidably switched between the first position and the second position; when the slidable cover plate 2 is in the first position, all The slidable cover 2 opens the side wall opening 5; when the slidable cover 2 is in the second position, the slidable cover 2 and the cover lock 6 After engaging, the slidable cover 2 is fastened by the cover lock 6 , and the slidable cover 2 closes the side wall opening 5 .

The nanotube capable of promoting self-selective nerve repair according to the present invention is a semi-closed nanotube, which can be used to allow the nerve to be inserted during the operation. The nerve is an exposed nerve without a nerve sheath, or Nerves that have developed lesions or membranous degeneration. The above-mentioned nerve groups are placed in the nanotubes, and the unidirectional locking nanotubes are adjusted after placement, so as to promote the degradation of the nerves after repairing. The nanotube is adapted to the environment with effusion, and root sleeve reconstruction and reinforcement forming surgery can be performed outside the nanotube.

The nanotube body 1 is a long cylindrical, partially open basic structure. The length of the nanotube body 1 can be extended or set to different lengths. Different diameters (2mm, 4mm, 6mm) are suitable for different numbers of nerve roots in the cyst and different numbers of damaged nerves. The nanotubes can be pre-laid with slow-release nerve regeneration stimulating factors , the nanotubes can self-degrade within 3 years.

Both the top 3 and the bottom 4 of the nanotube body 1 are hollow openings. Because the nerve is in this tube (namely nanotube body 1), the nerve is continuous, the nanotube contains the damaged nerve part, the proximal end of the nerve starts from the end of the dura mater, and the distal end of the nerve needs to continue to travel to the periphery of the distal end target organ.

The nanotube thin wall of the nanotube body 1 forms a long cylindrical structure, which can be two fan-shaped (the first fan cylinder 11 and the second fan cylinder 12 as shown in FIG. 4 ), and the opening is generally unlocked. . The two fan cylinders (the first fan cylinder 11 and the second fan cylinder 12 ) on the opposite side of the sidewall opening 5 may partially overlap (for example, in the range of A1 to A2 as shown in FIG. The tube is in an open mouth, not a loose one.

When the nanotubes capable of promoting self-selective nerve repair are in the open state, the overlapping parts of the first fan cylinder 11 and the second fan cylinder 12 are connected by limit hinge strips, which ensures and defines the side The widths of the wall openings 5 are 1.5 mm, 2.5 mm, and 3.5 mm, respectively corresponding to different diameters (4 mm, 6 mm, and 8 mm).

Preferably, the material of the nanotubes that can promote self-selective nerve repair is chitosan, but other basic materials of nanotubes are not excluded.

Preferably, the wall thickness of the nanotube body 1 is limited to about 1 mm.

When the nanotubes capable of promoting self-selective nerve repair of the present invention are used, nanotubes with different length specifications are selected according to the size of the cyst and the length of the damaged nerve, so as to ensure that the damaged nerve without nerve sheath is contained in the Inside the open nanotube body 1; the thickness of the nanotube is selected according to the thickness and quantity of the damaged nerve to ensure that the damaged nerve is placed in the open nanotube body in a loose state; the full length and all of the damaged or diseased nerve is contained After the opening of the nanotube body, the nerve regeneration stimulating factor in liquid or powder form for delayed degradation can be directly sprayed; the nanotube body contains the damaged nerve after neurotrophic treatment, and the damaged nerve is checked again to confirm The full length of the nanotube is in the open nanotube body, and there is no extrusion and crowding conditions, and the nanotube is pulled and closed by a specific instrument arm; the opening edge part of the side wall opening 5 is provided with a cover plate lock 6; After closing the nanotube, fasten the cover plate to ensure that the nanotube is no longer open.

Preferably, the cover plate locks 6 are set at intervals of 1.9 cm along the length direction of the nanotube body 1 , and the number of the cover plate locks 6 provided on the nanotube bodies with different lengths varies. , the 2cm long nanotube body is provided with 2 cover plate locks, the 4cm long nanotube body is provided with 3 cover plate locks, and the 6cm long nanotube body is provided with 4 cover plate locks.

Once the cover plate lock 6 is locked, it cannot be opened again unless external force damage or degradation occurs.

The preset degradation age of the nanotubes capable of promoting self-selective nerve repair of the present invention is 3 years.

In a specific implementation case, the hospital admitted a 48-year-old female patient with sacral cyst. After sitting, standing, and walking for a long time, the sacrococcygeal perineal tingling and numbness for 10 years, aggravated for 1 year, frequent urination for half a year, and urinary incontinence. January. Preoperative imaging and intraoperative microscopy confirmed that the cyst had a maximum diameter of 4.2 cm, containing 3 damaged nerves, and the 3 nerves formed a bundle with a total diameter of about 6.5 mm. Choose to place a bundle of damaged nerves in an open nanotube with a length of 4cm and a diameter of 8mm, and then spray the nerve regeneration stimulating factor to ensure that the nerve is in a loose state, close the nanotube with a specific instrument, and lock the three cover plates. Buckle up. Then proceed to root sleeve reconstruction and artificial dural reinforcement. Postoperatively, the patient's perineal numbness persisted, accompanied by difficulty in defecation. Three months after the operation, the numb area gradually produced a sense of current surging, and the perianal muscles felt throbbing. One year after the operation, the perineal numbness and defecation difficulty gradually improved. After three years, the perineum felt normal, and the second stool was normal.

The nanotube capable of promoting self-selective nerve repair of the present invention is an inclusive, openable and closable self-selective nerve repair nanotube, which can promote the self-selective repair of sacral nerves, and not only facilitates the self-selection of sacral nerves Sexual repair, and nerve containment can be protected.

The preferred embodiments of the present invention have been described above, but are not intended to limit the present invention. Modifications and variations of the embodiments disclosed herein may be made by those skilled in the art without departing from the scope and spirit of the invention.

Claims (10)

1. A nanotube capable of promoting self-selective nerve repair, comprising a hollow nanotube body and a slidable cover plate, wherein a sidewall opening part is arranged on a sidewall of the nanotube body, and the sidewall opening part extends along the length direction of the nanotube body; the inner part of the nanotube body is provided with a hollow cavity, and the hollow cavity is used for containing a nerve structure which is not completely broken and/or a nerve sheath membrane which is not used for wrapping the exposed nerve; the slidable cover plate is arranged on one side of the side wall opening part; a cover plate lock catch is arranged on the other side of the side wall opening part; the slidable cover plate can be switched between a first position and a second position in a sliding mode; when the slidable cover plate is at the first position, the slidable cover plate opens the side wall opening part; when the slidable cover plate is at the second position, the slidable cover plate is in lock joint with the cover plate, the slidable cover plate is locked by the cover plate lock catch, and the opening part of the side wall is sealed by the slidable cover plate.

2. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the nanotube body has a long cylindrical, partially open structure.

3. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the nanotube body is extensible in length.

4. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the nanotube body has a length of 2cm, 4cm or 6cm, and an inner diameter of 2mm, 4mm, 6mm or 8mm, wherein nanotube bodies of different inner diameters are adapted to accommodate different numbers of damaged nerves.

5. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the interior of the nanotube body is pre-laid with a slow release nerve regeneration stimulating factor.

6. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the nanotube capable of promoting self-selective nerve repair is capable of self-degradation within 3 years.

7. The nanotube capable of promoting self-selective nerve repair according to claim 4, wherein a width of a sidewall opening portion provided on the nanotube body having an inner diameter of 4mm is 1.5 mm; the width of a side wall opening part arranged on the nanotube body with the inner diameter of 6mm is 2.5 mm; the width of the side wall opening part arranged on the nanotube body with the inner diameter of 8mm is 3.5 mm.

8. The nanotube for promoting self-selective nerve repair according to claim 1, wherein the nanotube for promoting self-selective nerve repair is made of chitosan nanomaterial.

9. The nanotube capable of promoting self-selective nerve repair of claim 1, wherein the nanotube body has a wall thickness of 1 mm.

10. The nanotube of claim 1, wherein one cover lock is disposed every 1.9cm along the length of the nanotube body, and the number of cover locks disposed on nanotube bodies having different lengths is different.

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