CN114668409A - Human body neural interface system and method based on optogenetic regulation - Google Patents

Abstract

The invention provides a human neural interface system and method based on optogenetic regulation. The system includes: a light source stimulation parameter setting module, which is used to set light source stimulation parameters and generate illumination that conforms to the light source stimulation parameters; a neuroelectric regulation parameter monitoring module, It is used to stimulate the target neurons with light source, and monitor the response parameters of the organism after the target neurons are stimulated by the light source; the comparison prediction module is used to input the light source stimulation parameters and response parameters into the established prediction model, and obtain The relationship between light source stimulation parameters and response parameters is used to analyze the human neural interface. The present invention can obtain the relationship between the response parameters after being stimulated by the light source and the light source stimulation parameters through the prediction model, so as to obtain the relationship between the light source stimulation parameters, neurons and the behavior of the organism, and form a photoelectric physical model to analyze the human neural interface .

Description

Human neural interface system and method based on optogenetic regulation

technical field

The invention relates to the technical field of optogenetics, in particular to a human neural interface system and method based on optogenetic regulation.

Background technique

The research on the combination of optogenetics and microelectronics has many obvious advantages, and has been widely used in neuroscience, cell biology, biomedicine and other fields, and has broad application prospects. This light regulation technology of optogenetics is an important direction of brain-computer interface. The human neural interface can also be called brain-computer interface. Brain-Computer Interface (Brain-Computer Interface or Brain-Machine Interface, BMI) The communication system, which relies on the normal output pathways of the brain, realizes the direct information exchange between the brain and the external environment. Brain-computer interface can be mainly divided into two forms: "brain control" and "machine control". Stimulation signals realize the regulation of brain activity. The brain-computer button in the form of machine control has been widely used in researches such as neural function regulation and sensory information feedback.

The ultimate goal of optogenetics, brain science, and human-computer interface is to perceive the relationship between certain neurons and behaviors of the human body or organism through a series of external means. It uses the stimulation method to complete some physical behaviors stimulated by the human body or the inner body of the organism, and the current technology is mostly limited to the level of robots.

Therefore, how to design and propose an optoelectronic physical model to realize the effective connection between thoughts and behaviors, and how to complete an optoelectronic physical model to explain this imagination, is a problem that needs to be solved in the current subject.

SUMMARY OF THE INVENTION

The present invention provides a human neural interface system and method based on optogenetic regulation, which is used to solve the defect that optogenetics is limited to the level of robots in the prior art, so as to realize the effective connection of thoughts and behaviors through optoelectronic physical models.

The invention provides a human neural interface system based on optogenetic regulation, comprising: a light source stimulation parameter setting module, a neural electrical regulation parameter monitoring module and a comparison prediction module connected in sequence;

a light source stimulation parameter setting module, used for setting light source stimulation parameters and generating illumination that conforms to the light source stimulation parameters;

The nerve electrical regulation parameter monitoring module is used to stimulate the target neuron with light according to the light source stimulation parameters, and monitor the response parameters of the organism after the target neuron is stimulated by the light source;

The comparison prediction module is used to compare and analyze the response parameters obtained after the light stimulation that meets the light source stimulation parameters and the normal parameters of the organism, and input the light source stimulation parameters and response parameters into the established prediction model to obtain the light source. Interaction of stimulus parameters and response parameters for analysis of human neural interfaces.

A human neural interface system based on optogenetic regulation provided according to the present invention further includes: a neuron module, connected to the light source stimulation parameter setting module, for determining target neurons, and carrying the CHR2 light-sensitive protein on the AAV is implanted into the target neuron site on a non-toxic vector.

According to a human neural interface system based on optogenetic regulation provided by the present invention, the comparison prediction module includes a comparison analysis sub-module and a prediction sub-module;

The comparative analysis sub-module is used to compare and analyze the response parameters obtained after the light stimulation in accordance with the light source stimulation parameters and the normal parameters of the organism, and obtain the influence of the light source stimulation on the normal parameters of the organism based on the comparative analysis results;

The prediction sub-module is used to input the set light source stimulation parameters and the response parameters into the established prediction model, and obtain the function relationship between the light source stimulation parameters and the response parameters in combination with the comparative analysis results, so as to interface with the human nerve. analysis.

According to a human neural interface system based on optogenetic regulation provided by the present invention, the comparative analysis sub-module is specifically used for:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters with the normal parameters of the organism, the difference between the parameters of the organism under normal conditions and under the condition of light stimulation is obtained;

The influence of the light source stimulation parameters on the normal parameters of the organism is obtained based on the parameter difference, and the influence of the light source stimulation parameters on the target neuron is further obtained based on the influence of the light source stimulation parameters on the normal parameters of the organism.

A human neural interface system based on optogenetic regulation provided according to the present invention further comprises a control driving module;

The control and driving module is connected to the light source stimulation parameter setting module, and is configured to drive the light source stimulation parameter setting module based on a constant voltage or constant current circuit to generate illumination conforming to the light source stimulation parameters.

According to a human neural interface system based on optogenetic regulation provided by the present invention, the light source stimulation parameter setting module includes: a parameter setting sub-module and a light source sub-module connected in sequence, the light source sub-module and the neuroelectrical Control parameter monitoring module connection;

The parameter setting submodule is used to set the light source stimulation parameters based on the multi-parameter optimization algorithm;

The light source sub-module is configured to generate illumination that conforms to the light source stimulation parameter.

According to a human neural interface system based on optogenetic regulation provided by the present invention, the light source sub-module is a Micro LED light source;

Wherein, the Micro LED light source is a point light source or a light source array.

According to a human neural interface system based on optogenetic regulation provided by the present invention, the light source stimulation parameters include the light-emitting mode of the light source, the light intensity, the light frequency, the driving voltage of the light, the driving current of the light, the temperature of the light, and the light source of the light source. at least one of the shapes.

The present invention also provides a human neural interface method based on optogenetic regulation, comprising:

Setting light source stimulation parameters and generating illumination that conforms to the light source stimulation parameters;

The target neuron is stimulated with light according to the light source stimulation parameters, and the response parameters of the organism caused by the target neuron being stimulated by the light source are monitored;

The response parameters obtained after the light stimulation in line with the light source stimulation parameters and the normal parameters of the organism are compared and analyzed, and the light source stimulation parameters and the response parameters are input into the established prediction model to obtain the light source stimulation parameters and response parameters. Action relationship to analyze the human neural interface.

According to a human neural interface method based on optogenetic regulation provided by the present invention, the response parameters obtained after light stimulation that conform to the light source stimulation parameters and the normal parameters of the organism are compared and analyzed, and the light source stimulation parameters and the response parameters are compared and analyzed. Input into the established prediction model to obtain the relationship between light source stimulation parameters and response parameters to analyze the human neural interface, including:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters and the normal parameters of the organism, and obtaining the influence of the light source stimulation on the normal parameters of the organism based on the results of the comparative analysis;

The set light source stimulation parameters and the response parameters are input into the established prediction model, and the relationship between the light source stimulation parameters and the response parameters is obtained in combination with the comparative analysis results to analyze the human neural interface.

According to a human neural interface method based on optogenetic regulation provided by the present invention, the reaction parameters and the normal parameters of the organism are compared and analyzed, and the influence of light source stimulation on the normal parameters of the organism is obtained based on the results of the comparison and analysis, including:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters with the normal parameters of the organism, the difference between the parameters of the organism under normal conditions and under the condition of light stimulation is obtained;

The influence of the light source stimulation parameters on the normal parameters of the organism is obtained based on the parameter difference, and the influence of the light source stimulation parameters on the target neuron is further obtained based on the influence of the light source stimulation parameters on the normal parameters of the organism.

In the human neural interface system and method based on optogenetic regulation provided by the present invention, the light source stimulation parameters are set by the light source stimulation parameter setting module and the illumination that conforms to the light source stimulation parameters is generated; The target neuron is stimulated by light source, and the response parameters of the organism caused by the target neuron after being stimulated by the light source are monitored. Contrast and analyze, and input the light source stimulation parameters and response parameters into the established prediction model, and obtain the function relationship between the light source stimulation parameters and the response parameters to analyze the human neural interface. The present invention can obtain the relationship between the response parameters stimulated by the light source and the light source stimulation parameters through the prediction model, so as to obtain the relationship between the light source stimulation parameters, neurons and the behavior of the organism, and form an optoelectronic physical model to analyze the human neural interface .

Description of drawings

In order to explain the present invention or the technical solutions in the prior art more clearly, the following will briefly introduce the accompanying drawings that need to be used in the description of the embodiments or the prior art. Obviously, the accompanying drawings in the following description are the For some embodiments of the invention, for those of ordinary skill in the art, other drawings can also be obtained according to these drawings without any creative effort.

Fig. 1 is one of the structural representations of the human neural interface system based on optogenetic regulation provided by the present invention;

Fig. 2 is the second structural schematic diagram of the human neural interface system based on optogenetic regulation provided by the present invention;

Fig. 3 is the third structural schematic diagram of the human neural interface system based on optogenetic regulation provided by the present invention;

4 is the fourth schematic diagram of the structure of the human neural interface system based on optogenetic regulation provided by the present invention;

Fig. 5 is one of the schematic flow charts of the human neural interface method based on optogenetic regulation provided by the present invention;

Fig. 6 is the second schematic flow chart of the human neural interface method based on optogenetic regulation provided by the present invention;

Fig. 7 is the third schematic flow chart of the human neural interface method based on optogenetic regulation provided by the present invention;

FIG. 8 is a fourth schematic flowchart of the method for human neural interface based on optogenetic regulation provided by the present invention.

Detailed ways

In order to make the objectives, technical solutions and advantages of the present invention clearer, the technical solutions in the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention. , not all examples. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

The human neural interface system and method based on optogenetic regulation of the present invention will be described below with reference to FIGS. 1 to 8 .

1, the human neural interface system based on optogenetic regulation of the present invention includes: a light source stimulation parameter setting module 110, a neural electrical regulation parameter monitoring module 120, and a comparison prediction module 130, which are connected in sequence;

a light source stimulation parameter setting module 110, configured to set light source stimulation parameters and generate illumination that conforms to the light source stimulation parameters;

The neuroelectrical regulation parameter monitoring module 120 is used to stimulate the target neuron with light that meets the light source stimulation parameters, and monitor the response parameters of the organism caused by the target neuron being stimulated by the light source;

The comparison prediction module 130 is used to compare and analyze the response parameters obtained after the light stimulation in accordance with the light source stimulation parameters and the normal parameters of the organism, and input the light source stimulation parameters and response parameters into the established prediction model to obtain The relationship between light source stimulation parameters and response parameters is used to analyze the human neural interface.

Wherein, the light source stimulation parameters include at least one of the light-emitting mode, light intensity, light frequency, light driving voltage, light driving current, light temperature and shape of the light source.

In this embodiment, the light source stimulation parameters are set by the light source stimulation parameter setting module, and illumination that conforms to the light source stimulation parameters is generated. It should be noted that the light source stimulation parameters here include but are not limited to lighting mode, light intensity, light source shape, light frequency, light source temperature, driving voltage and driving current.

Referring to FIG. 2 , the light source stimulation parameters are set based on the light source parameter control algorithm in combination with these parameters, and illumination that conforms to the set parameters is generated.

The light source stimulation parameter setting module in this embodiment can implement customized light sources according to the types of neurons, so as to complete the light stimulation of neurons.

In this embodiment, the nerve electrical regulation parameter monitoring module is used to stimulate the target neuron with light source through illumination, and then the response parameters of the stimulated organism are obtained by monitoring. It should be noted that the neuroelectrical regulation parameter monitoring module mainly monitors some functional responses or instinctive responses of the organism caused by irradiating a certain neuron with a light source.

The neuroelectrical regulation parameter monitoring module adopts the method of combining external instruments and traditional bioelectrical monitoring. Through this method, a closed-loop system is realized, and the light source algorithm is finally optimized to achieve the optimum, and at the same time, a parameter framework is built for the model.

Referring to FIG. 3 , the neurons are detected by biosensors and monitored by medical or biological instruments, respectively.

Continuing to refer to FIG. 1 , the comparative prediction module is used for comparative analysis and detection. On the one hand, by detecting the parameters of the neurons stimulated by the light source and the normal parameters of the organism to judge, and through comparative analysis, some results that are helpful for medical or biological research can finally be obtained. For example: the primary neurons of the optic nerve are stimulated with a light source, so that the vision of the original myopia or vision-related diseases can be corrected. On the other hand, by putting the customized parameters of the light source and the parameters of the organism stimulated by the light source into an algorithm model, the model obtains the light source between the neuron and the organism through analysis, so that some brains such as the external light source can be controlled. The machine interface means to replace the human senses or heart, and complete the change of the biological behavior through light control. The establishment of the model can use machine learning and statistical algorithms.

In the human neural interface system based on optogenetic regulation provided by the present invention, the light source stimulation parameter setting module is used to set the light source stimulation parameters and generate illumination that conforms to the light source stimulation parameters, and the light source conforming to the light source stimulation parameters is adjusted by the nerve electrical regulation parameter monitoring module. The target neuron is stimulated by the light source, and the response parameters of the organism caused by the target neuron after being stimulated by the light source are monitored. , and input the light source stimulation parameters and response parameters into the established prediction model, and obtain the function relationship between the light source stimulation parameters and the response parameters to analyze the human neural interface. The present invention can obtain the relationship between the response parameters stimulated by the light source and the light source stimulation parameters through the prediction model, so as to obtain the relationship between the light source stimulation parameters, neurons and the behavior of the organism, and form an optoelectronic physical model to analyze the human neural interface .

Based on the above embodiment, a neuron module is also included, which is connected to the light source stimulation parameter setting module and is used to determine the target neuron, and the CHR2 light-sensitive protein is loaded on the AAV non-toxic carrier and implanted into the target neuron The location of the element.

Referring to FIG. 4 , the neuron module in this embodiment is mainly used to complete the determination of different neurons, and then the CHR2 light-sensitive protein is loaded on the AAV non-toxic carrier and implanted at the designated position of the neuron. Among them, the position of neurons is determined according to the actual research direction.

Based on the above embodiment, the comparative prediction module includes a comparative analysis sub-module and a prediction sub-module;

The comparative analysis sub-module is used to compare and analyze the response parameters obtained after the light stimulation in accordance with the light source stimulation parameters and the normal parameters of the organism, and obtain the influence of the light source stimulation on the normal parameters of the organism based on the comparative analysis results;

The prediction sub-module is used to input the set light source stimulation parameters and the response parameters into the established prediction model, and obtain the function relationship between the light source stimulation parameters and the response parameters in combination with the comparative analysis results, so as to interface with the human nerve. analysis.

Specifically, the comparison prediction module in this embodiment includes two sub-modules, which are respectively used for comparison analysis and detection.

Among them, the comparative analysis sub-module makes judgments by detecting the parameters of the neurons stimulated by the light source and the normal parameters of the organism. Through the comparative analysis, some results that are helpful for medical or biological research can finally be obtained. For example: the primary neurons of the optic nerve are stimulated with a light source, so that the vision of the original myopia or vision-related diseases can be corrected.

The detection module puts the customized parameters of the light source and the parameters of the organism stimulated by the light source into a prediction model. The prediction model obtains the light source between the neuron and the organism through analysis, so that some brains such as the external light source can be controlled. The machine interface means to replace the human senses or heart, and complete the change of biological behavior through light control. Among them, the establishment of predictive models can use machine learning and statistical algorithms.

Based on the above embodiment, the comparative analysis sub-module is specifically used for:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters with the normal parameters of the organism, the difference between the parameters of the organism under normal conditions and under the condition of light stimulation is obtained;

The influence of the light source stimulation parameters on the normal parameters of the organism is obtained based on the parameter difference, and the influence of the light source stimulation parameters on the target neuron is further obtained based on the influence of the light source stimulation parameters on the normal parameters of the organism.

Specifically, in this embodiment, by comparing and analyzing the response parameters obtained after light stimulation and the normal parameters of the organism, the difference between the normal parameters of the organism and the parameters stimulated by light is obtained, and the effect of the light source stimulation parameters on the organism is obtained. and target neurons. In the fields of medicine and biology, biological research and disease treatment can be carried out according to the parameters of light source stimulation.

Based on the above embodiment, it also includes a control driving module;

The control and driving module is connected to the light source stimulation parameter setting module, and is configured to drive the light source stimulation parameter setting module based on a constant voltage or constant current circuit to generate illumination conforming to the light source stimulation parameters.

Specifically, the control and drive module in this embodiment includes a control part and a drive part, and the control chip and the drive chip respectively perform command transmission. The control chip mainly uses FPGA or STM32 as the control part, and the self-developed driver chip is mainly a constant voltage or constant current drive circuit that meets the light drive parameters.

The control driving module sends a control driving instruction to the light source stimulation parameter setting module, and after receiving the control driving instruction, the light source stimulation parameter setting module generates illumination that conforms to the light source stimulation parameters for illuminating the target neurons.

Based on the above embodiment, the light source stimulation parameter setting module includes: a parameter setting sub-module and a light source sub-module connected in sequence, and the light source sub-module is connected with the nerve electrical regulation parameter monitoring module;

The parameter setting submodule is used to set the light source stimulation parameters based on the multi-parameter optimization algorithm;

The light source sub-module is configured to generate illumination that conforms to the light source stimulation parameter.

The light source sub-module is a Micro LED light source;

Wherein, the Micro LED light source is a point light source or a light source array.

Specifically, the light source parameter setting module in this embodiment is classified into two sub-modules, which are respectively used for light source stimulation parameters and according to generate illumination that conforms to the light source stimulation parameters.

The light source in this embodiment is mainly Micro LED, and Micro LED is a customized light source suitable for optogenetics developed by ourselves.

The human neural interface method based on optogenetic regulation provided by the present invention is described below, and the human neural interface method based on optogenetic regulation described below and the human neural interface system based on optogenetic regulation described above can be referred to each other correspondingly.

Referring to Fig. 5, a method for human neural interface based on optogenetic regulation provided by the present invention comprises the following steps:

Step 510: Set light source stimulation parameters and generate illumination that conforms to the light source stimulation parameters;

Step 520: Stimulate the target neuron with light that matches the light source stimulation parameters, and monitor the response parameters of the organism caused by the target neuron being stimulated by the light source;

Step 530: Compare and analyze the response parameters obtained after the light stimulation that meets the light source stimulation parameters and the normal parameters of the organism, and input the light source stimulation parameters and response parameters into the established prediction model to obtain the light source stimulation parameters and The role relationship of the response parameters to analyze the human neural interface.

Based on the above embodiments, after setting the light source stimulation parameters and generating illumination that conforms to the light source stimulation parameters, the method further includes:

The target neurons were determined, and the CHR2 light-sensitive protein was loaded on the AAV non-toxic carrier and implanted at the position of the target neurons.

Based on the above embodiment, the response parameters obtained after the light stimulation in accordance with the light source stimulation parameters and the normal parameters of the organism are compared and analyzed, and the light source stimulation parameters and response parameters are input into the established prediction model to obtain the light source stimulation The relationship between parameters and response parameters to analyze the human neural interface, including:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters and the normal parameters of the organism, and obtaining the influence of the light source stimulation on the normal parameters of the organism based on the results of the comparative analysis;

The set light source stimulation parameters and the response parameters are input into the established prediction model, and the relationship between the light source stimulation parameters and the response parameters is obtained in combination with the comparative analysis results to analyze the human neural interface.

Based on the above embodiment, the reaction parameters and the normal parameters of the organism are compared and analyzed, and the influence of the light source stimulation on the normal parameters of the organism is obtained based on the results of the comparison and analysis, including:

Comparing and analyzing the response parameters obtained after light stimulation that conforms to the light source stimulation parameters with the normal parameters of the organism, the difference between the parameters of the organism under normal conditions and under the condition of light stimulation is obtained;

The influence of the light source stimulation parameters on the normal parameters of the organism is obtained based on the parameter difference, and the influence of the light source stimulation parameters on the target neuron is further obtained based on the influence of the light source stimulation parameters on the normal parameters of the organism.

Referring to FIG. 6 , the method for human neural interface based on optogenetic regulation of the present invention is described by a specific example flow chart, including the following steps:

Step 610, determination of light source parameters.

Among them, the parameters of the light source determine whether the neurons are activated, and the parameters such as the voltage, current, wavelength, optical power, and electrical power of the chip are mainly considered.

In step 620, after the neurons are stimulated by the light source, the changes caused by the neurons are monitored through electrode monitoring or medical instruments.

Among them, the neurons mainly stimulate the superficial visual neurons.

Step 630 : Establish a prediction model based on the parameters of the light source and the monitoring parameters of the neurons, and obtain the function relationship between the parameters of the light source and the monitoring parameters of the neurons, so as to realize accurate positioning and prediction of light, neurons, and perception.

7, the human neural interface method based on optogenetic regulation provided by the present invention includes:

710. Set light source parameters;

720. Set the type of photosensitive protein;

730. The light source is implanted into a specific neuron to illuminate;

740. Medical instruments monitor changes in biological parameters caused by neurons;

750. Enter the machine learning algorithm to predict the model according to the light source, light-sensitive protein and monitoring parameters;

760. Continuously optimize the model through light source parameters;

770. Realize the correspondence of neurons through the light source;

780. Realize precise regulation of neurons by light source through the model.

Referring to FIG. 8 , FIG. 8 is a flowchart of a software program of a method for human neural interface based on optogenetic regulation of the present invention. By controlling the driving module to drive the light source stimulation parameter setting module to generate illumination that conforms to the light source stimulation parameters, the specific steps are as follows.

After the program starts:

S1. Start to detect whether the IO port is connected? If there is no connection, the program ends, if there is a connection, execute S2;

S2. Send a drive enable signal to IO and activate the drive chip;

S3. Whether the driver is in working state. If otherwise, the program ends, and if so, execute S4;

S4. Detect whether the drive output pin is connected to the light source. If otherwise, the program ends, if so, execute S5;

S5. Whether the connection of each IO port is completed. If otherwise, the program ends, and if so, execute S6;

S6. The control chip controls the port to emit light waves of the specified wavelength and frequency;

S7, set whether the irradiation time ends. If otherwise the program ends, if so, execute S8;

S8, the control of the light source ends.

until the program ends.

The embodiments described above are only illustrative, wherein the units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in a local, or it can be distributed over multiple network elements. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution in this embodiment. Those of ordinary skill in the art can understand and implement it without creative effort.

From the description of the above embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus a necessary general hardware platform, and certainly can also be implemented by hardware. Based on this understanding, the above-mentioned technical solutions can be embodied in the form of software products in essence or the parts that make contributions to the prior art, and the computer software products can be stored in computer-readable storage media, such as ROM/RAM, magnetic A disc, an optical disc, etc., includes several instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to perform the methods described in various embodiments or some parts of the embodiments.

Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, but not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that it can still be The technical solutions described in the foregoing embodiments are modified, or some technical features thereof are equivalently replaced; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims (12)

1. A human neural interface system based on optogenetic modulation, comprising: the device comprises a light source stimulation parameter setting module, a nerve electrical control parameter monitoring module and a comparison prediction module which are sequentially connected;

the light source stimulation parameter setting module is used for setting light source stimulation parameters and generating illumination according with the light source stimulation parameters;

the nerve electrical control parameter monitoring module is used for performing light source stimulation on the target neuron by the illumination which accords with the light source stimulation parameter, and monitoring the response parameter of the organism caused by the stimulation of the target neuron by the light source;

and the comparison and prediction module is used for performing comparison and analysis on the reaction parameters and the normal parameters of the organism obtained after the illumination stimulation conforming to the light source stimulation parameters, inputting the light source stimulation parameters and the reaction parameters into the established prediction model, and obtaining the action relation between the light source stimulation parameters and the reaction parameters so as to analyze the human neural interface.

2. The optogenetically regulated human neural interface system of claim 1, further comprising:

and the neuron module is connected with the light source stimulation parameter setting module and is used for determining a target neuron and carrying the CHR2 light sensitive protein on an AAV nontoxic carrier to implant the AAV light sensitive protein at the position of the target neuron.

3. The optogenetically manipulated human neural interface system of claim 1, wherein the comparative prediction module comprises a comparative analysis sub-module and a prediction sub-module;

the comparison analysis submodule is used for performing comparison analysis on the reaction parameters obtained after illumination stimulation conforming to the light source stimulation parameters and the normal parameters of the organism and obtaining the influence of the light source stimulation on the normal parameters of the organism based on the comparison analysis result;

and the prediction submodule is used for inputting the set light source stimulation parameters and the reaction parameters into the established prediction model and obtaining the action relation between the light source stimulation parameters and the reaction parameters by combining the comparison analysis results so as to analyze the human body neural interface.

4. The optogenetically manipulated human neural interface system of claim 3, wherein the comparative analysis submodule is specifically configured to:

comparing and analyzing the reaction parameters obtained after the illumination stimulation conforming to the light source stimulation parameters with the normal parameters of the organism to obtain the parameter difference value of the organism under the normal condition and the illumination stimulation condition;

and obtaining the influence of the light source stimulation parameters on the normal parameters of the organism based on the parameter difference, and further obtaining the influence of the light source stimulation parameters on the target neurons based on the influence of the light source stimulation parameters on the normal parameters of the organism.

5. The optogenetically manipulated human neural interface system of claim 1, further comprising a control driver module;

the control driving module is connected with the light source stimulation parameter setting module and used for driving the light source stimulation parameter setting module to generate illumination meeting the light source stimulation parameters based on a constant voltage or constant current circuit.

6. The optogenetically manipulated human neural interface system of claim 1, wherein the light source stimulation parameter setting module comprises: the parameter setting submodule and the light source submodule are connected in sequence, and the light source submodule is connected with the nerve electric control parameter monitoring module;

the parameter setting submodule is used for setting light source stimulation parameters based on a multi-parameter optimization algorithm;

and the light source submodule is used for generating illumination which accords with the light source stimulation parameter.

7. The optogenetically manipulated human neural interface system of claim 6, wherein the light source sub-module is a Micro LED light source;

wherein, the Micro LED light source is a point light source or a light source array.

8. The optogenetically manipulated human neural interface system of claim 1, wherein the light source stimulation parameter comprises at least one of a lighting pattern of the light source, a light intensity, a light frequency, a driving voltage of the light, a driving current of the light, a temperature of the light, and a shape of the light source.

9. A human neural interface method based on optogenetic modulation, implemented based on the human neural interface system based on optogenetic modulation according to any one of claims 1 to 8, comprising:

setting light source stimulation parameters and generating illumination according with the light source stimulation parameters;

performing light source stimulation on the target neuron by the illumination which accords with the light source stimulation parameter, and monitoring the response parameter of the organism caused by the stimulation of the target neuron by the light source;

and comparing and analyzing the reaction parameters obtained after the illumination stimulation conforming to the light source stimulation parameters with the normal parameters of the organism, and inputting the light source stimulation parameters and the reaction parameters into an established prediction model to obtain the action relation between the light source stimulation parameters and the reaction parameters so as to analyze the human neural interface.

10. The method of claim 9, wherein after setting the light source stimulation parameters and generating the illumination consistent with the light source stimulation parameters, further comprising:

target neurons were identified and CHR2 light sensitive proteins were implanted in the target neurons in place on AAV non-toxic vectors.

11. The method of claim 9, wherein the analyzing the neural interface of the human body by comparing the response parameters obtained after the light stimulation conforming to the light source stimulation parameters with the normal parameters of the living body and inputting the light source stimulation parameters and the response parameters into the established prediction model to obtain the action relationship between the light source stimulation parameters and the response parameters, comprises:

comparing and analyzing the reaction parameters obtained after the illumination stimulation conforming to the light source stimulation parameters with the normal parameters of the organism, and obtaining the influence of the light source stimulation on the normal parameters of the organism based on the comparison and analysis result;

and inputting the set light source stimulation parameters and the reaction parameters into the established prediction model, and combining the comparative analysis result to obtain the action relation between the light source stimulation parameters and the reaction parameters so as to analyze the human neural interface.

12. The method of claim 11, wherein the comparing and analyzing the response parameter and the normal parameter of the living body, and the obtaining the effect of the light source stimulation on the normal parameter of the living body based on the comparing and analyzing result comprises:

Comparing and analyzing the reaction parameters obtained after the illumination stimulation conforming to the light source stimulation parameters with the normal parameters of the organism to obtain the parameter difference value of the organism under the normal condition and the illumination stimulation condition;

and obtaining the influence of the light source stimulation parameters on the normal parameters of the organism based on the parameter difference, and further obtaining the influence of the light source stimulation parameters on the target neurons based on the influence of the light source stimulation parameters on the normal parameters of the organism.

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