CN114342826B - An electric shock device and its application - Google Patents

Abstract

The application belongs to the technical field of biomedicine, and particularly relates to an electric shock device and application. The existing animal models mainly adopt rodents, such as rats and mice. There are no relevant devices in large animals (e.g., pigs, dogs, monkeys, etc.). The application provides an electric shock device, including electric shock stimulator, circuit protection subassembly and the animal protection clothing that connects gradually, the animal protection clothing is including inlayer and the skin that stacks gradually, the inlayer is the metal level. The electric shock device is not interfered by external environment and equipment.

Description

An electric shock device and its application

technical field

The application belongs to the field of biomedical technology, and in particular relates to an electric shock device and its application.

Background technique

In biomedical research, electric shock is commonly used as an induction method in animal models. Its principle is to use the natural fear and avoidance characteristics of animals (including humans) to electric shocks, that is, when receiving electric shocks, they will produce uncomfortable feelings such as pain, and animals naturally hate this feeling and try to escape electric shocks. First, this sensation causes a kind of learning of the surrounding scene at the time of the shock, so it is often used to study learning memory and related post-traumatic stress syndrome. Second, when certain conditions are set so that the animal wants food or water very much, but there is a high possibility of electric shock, the animal will be in a state of anxiety, so it is also used to study anxiety disorders. Thirdly, when the electric shock cannot be escaped anyway, the animal will have the behavior of giving up and fleeing, that is, a state of despair or similar to depression, which is used to study depression. At present, the above-mentioned animal models mainly adopt rodents, such as rats and mice. The experimental device used is also dedicated to small animals, and is usually carried out using a "fear conditioning behavior box". Put the animal in the behavior box, light the lamp on the box wall or play a special sound, and at the same time apply a certain current to the metal strip at the bottom of the box , and last for a certain period of time, so as to shock the animal. In large animals (such as pigs, dogs, monkeys, etc.), there are no related devices and methods, especially in monkeys, because they can climb to the side walls and tops of behavior boxes or behavior cages, only at the bottom of the box. It is not feasible to apply an electric shock.

The existing electric shock devices are all carried out in the form of a behavior box. The bottom of the behavior box is composed of metal strips with positive and negative poles alternated and insulated from each other. When the animal’s limbs step on the positive and negative metal strips at the same time, if the metal strip is applied with current A current loop will be formed to produce electric shocks to animals. The current shortcoming of this technology has the following points: (1) the electric shocks in the prior art are all carried out by applying positive and negative poles to the electric shock metal strips between the phases. One of the disadvantages is that when the animal's limbs happen to be all positive or all negative, there is no current loop and thus no shock. (2) The prior art is not applicable to animals that can climb or stand on both feet, such as monkeys, dogs, etc. When the animal climbs to the side wall or top and leaves the electric shock metal strip, no electric shock will be generated; When the animal stands on two feet, there is a high probability that it will stand on the metal strip connected to the same pole, and it may not produce an electric shock. (3) Different from mice and mice, for large animals, it is more difficult to move animals frequently, especially after the animals have been stimulated by electric shocks before, they will react more when entering the behavior box again.

Contents of the invention

1. Technical problems to be solved

Based on existing animal models, rodents such as rats and mice are mainly used. However, in large animals (such as pigs, dogs, monkeys, etc.), there is no problem with related devices. This application provides an electric shock device and its application.

2. Technical solution

In order to achieve the above object, the present application provides an electric shock device, comprising an electric shock stimulator, a circuit protection component and an animal protective clothing sequentially connected, the animal protective clothing includes an inner layer and an outer layer stacked in sequence, the inner layer for the metal layer.

Another embodiment provided by the present application is: the circuit protection component is a rotor, and the rotor is connected with a metal protective hose.

Another embodiment provided by the present application is: the electric shock stimulator includes a positive pole and a negative pole, the rotor includes an external joint and an internal joint, and the positive pole is connected to the external joint.

Another embodiment provided by the present application is: the electric shock stimulator is connected with a smart terminal or a controller.

Another embodiment provided by the present application is: the internal joint of the rotor is connected to the metal layer through a wire, and the metal protection hose is arranged outside the wire.

Another embodiment provided by the present application is: the output current of the electric shock stimulator is an adjustable constant direct current.

The present application also provides an application of the electric shock device, which is characterized in that: the electric shock device is applied to fear-conditioned learning and memory models of large animals, post-traumatic stress syndrome animal models, anxiety animal models, Animal models of depression or animal models of drug addiction.

Another embodiment provided by the present application is: the electric shock stimulator is arranged above the breeding cage or the behavior cage, the circuit protection component is arranged above the breeding cage or the behavior cage, and the breeding cage or the behavior cage is made of metal Cage.

Another embodiment provided by the present application is: the electric shock stimulator generates stimulating current, passes through the circuit protection component, the metal layer reaches the skin of the trunk of the animal, returns to the electric shock stimulator through the metal cage, and forms The current loop forms an electric shock stimulus to the animal.

Another embodiment provided by the present application is: adjusting the magnitude of the current and the length of the stimulation time to set stimulation parameters through the electric shock stimulator.

3. Beneficial effect

Compared with the prior art, the beneficial effects of the electric shock device provided by the present application are:

The electric shock device provided in this application is an electric shock device free from interference from the external environment and equipment.

In the electric shock device provided by this application, the wire is connected to the animal protective clothing through a metal protective hose to prevent animals from scratching and biting the wire.

In the application of the electric shock device provided in this application, the electric shock stimulator is connected to the wire through the circuit protection component, which can prevent the wire from being entangled when the animal turns.

In the application of the electric shock device provided in this application, the metal layer of the animal protective clothing is connected to the wire and contacts the skin to form a current loop, which can ensure that the animal can be stimulated by electric shock at any position.

The application of the electric shock device provided in this application can give electric shock stimulation through operative behavior (such as pressing a bar, drinking water, etc.) or at an artificially set time, so as to establish a disease animal model in large animals.

The application of the electric shock device provided in this application can establish animal models such as electric shock-related learning and memory, electric shock-related anxiety, depression, and drug addiction in large animals (such as pigs, dogs, monkeys, etc.) for biomedical research.

Description of drawings

Fig. 1 is a schematic structural diagram of the electric shock device of the present application.

Detailed ways

Hereinafter, specific embodiments of the present application will be described in detail with reference to the accompanying drawings. According to these detailed descriptions, those skilled in the art can clearly understand the present application and can implement the present application. Without departing from the principle of the present application, the features in different embodiments can be combined to obtain new implementations, or some features in certain embodiments can be replaced to obtain other preferred implementations.

Referring to FIG. 1 , the present application provides an electric shock device, including an electric shock stimulator 1, a circuit protection component 2 and an animal protection clothing 3 connected in sequence, and the animal protection clothing 3 includes an inner layer and an outer layer stacked in sequence, and the inner layer layer is a metal layer.

The electric shock stimulator 1 can adopt the existing commercial electric shock stimulator. Compared with the existing method of using alternating electric shock metal strips to apply positive and negative poles, the metal layer of the animal protective clothing 3 designed by the present invention can ensure that no matter where the animal's limbs step on, even when the animal climbs to the top of the cage , still able to apply electric shock stimulation.

The metal layer can be any material with good conductivity.

Further, the circuit protection component 2 is a rotor, and the rotor is connected with a metal protection hose 4 .

A rotor is any device capable of maintaining conduction as one end of the wire rotates.

Further, the electric shock stimulator 1 includes a positive pole and a negative pole, the rotor includes an external connector, and the positive pole is connected to the external connector. There will not be a situation where the animal's body is at the same pole.

Further, the electric shock stimulator 1 is connected with a smart terminal or a controller.

Further, the rotor is connected to the metal layer through wires, and the metal protection hose 4 is arranged outside the wires. The special animal protective clothing 3 closely fits the animal trunk, the inner layer is a metal layer that can be in close contact with the body, and conducts current, and the outer layer is a nylon layer, which is durable. The animal protective clothing 3 is connected to the rotor through a metal protective hose.

The metal protective hose 4 can be any material with a certain strength that can prevent animals from biting.

Further, the output current of the electric shock stimulator 1 is an adjustable constant direct current.

The present application also provides an application of the electric shock device, applying the electric shock device to fear-conditioned learning and memory models of large animals, post-traumatic stress syndrome animal models, anxiety animal models, and depression animal models Or animal models of drug addiction. It can be used in large animals including monkeys, dogs, pigs, etc., together with visual or sound stimulation, to establish animal models such as shock-related learning and memory, shock-related anxiety, depression, and drug addiction for biomedical research.

Further, the electric shock stimulator 1 is set above the breeding cage or the behavior cage 5, and the circuit protection component 2 is set above the breeding cage or the behavior cage 5, and the breeding cage or the behavior cage 5 is a metal cage. The electric shock stimulator 1 is fixed above the behavior cage or breeding cage 5, and a partition is placed at the bottom to allow animals to touch and bite. After the electric wire is connected from the electric shock stimulator 1, it passes through the sealed metal protection tube 4 to reach the top or side of the behavior cage or breeding cage 5, wherein the negative pole is directly connected to the cage through a metal joint, and the positive pole is connected through the rotor fixed on the cage.

Shock experiments can be performed in home cages without transferring animals to behavioral cages.

The positive pole is connected to the external joint of the rotor, and the rotor is fixed on the cage. The other end of rotor stretches in the cage, and is connected with the inner metal layer of animal protective clothing 3 by lead wire, and lead wire is protected by metal protection hose 4. Thanks to the rotor, the circuit is kept on even when the animal is turning.

Further, open the electric shock stimulator manually or use signals such as computers and controllers to open the electric shock stimulator 1, and generate a stimulating current through the circuit protection component 2, the metal layer reaches the skin of the trunk of the animal, and returns through the metal cage. The electric shock stimulator 1 forms a current loop to form electric shock stimulation to animals.

By connecting the positive and negative poles of the electric shock stimulator 1 to the metal behavior cage (or breeding cage) 5 and the animal protective clothing 3, the inside of the animal protective clothing 3 is in contact with the skin through the metal layer. It can pass through the metal layer of the animal protective clothing 3, pass through the animal's body, and then return to the electric shock stimulator 1 through the metal cage in contact with the limbs of the animal, thereby forming a current loop and causing electric shock to the animal. By combining visual stimulation and sound stimulation, animal models such as electric shock-related learning and memory, electric shock-related anxiety, depression, and drug addiction can be established in the above-mentioned large animals to conduct related biomedical research.

Further, the electric shock stimulator 1 adjusts the magnitude of the current and the length of the stimulation time to set stimulation parameters.

The whole set can be installed on any box where animals are kept or temporarily observed.

Although the present application has been described above with reference to specific embodiments, those skilled in the art should understand that many modifications can be made to the configurations and details disclosed in the present application within the principles and scope disclosed in the present application. The protection scope of the present application is determined by the appended claims, and the claims are intended to cover all modifications included in the equivalent literal meaning or scope of the technical features in the claims.

Claims (6)

1. An electric shock device, characterized in that: it comprises an electric shock stimulator, a circuit protection assembly and an animal protective clothing connected in sequence, the animal protective clothing comprises an inner layer and an outer layer stacked in sequence, the inner layer is a metal layer, The metal layer is made of conductive material; the circuit protection component is a rotor, and the rotor is connected with a metal protection hose; The electric shock stimulator includes a positive pole and a negative pole, and the rotor includes an external joint, and the positive pole is connected to the external joint; the positive pole is connected to the external joint of the rotor, and the rotor is fixed on a breeding cage or a behavioral cage above; the other end of the rotor extends into the cage, and is connected to the inner metal layer of the animal protective clothing through wires, and the wires are protected through the metal protective hose; The electric shock stimulator is arranged above the breeding cage or the behavior cage, and the circuit protection component is arranged above the breeding cage or the behavior cage, and the breeding cage or the behavior cage is a metal cage; the electric shock stimulator generates a stimulating current , through the circuit protection component, the metal layer reaches the skin of the trunk of the animal, returns to the electric shock stimulator through the metal cage, forms a current loop, and forms an electric shock stimulation to the animal. 2. The electric shock device according to claim 1, wherein the electric shock stimulator is connected with a smart terminal or a controller. 3. The electric shock device according to claim 1, wherein the rotor is connected to the metal layer through a wire, and the metal protection hose is arranged outside the wire. 4. The electric shock device according to any one of claims 1-3, wherein the output current of the electric shock stimulator is an adjustable constant direct current. 5. An application of the electric shock device according to any one of claims 1 to 4, characterized in that: the electric shock device is applied to fear-conditioned learning and memory models of large animals, post-traumatic stress syndrome animals Models, animal models of anxiety, animal models of depression or animal models of drug addiction. 6. The application of the electric shock device according to claim 5, characterized in that: the electric shock stimulator adjusts the magnitude of the current and the length of stimulation time to set stimulation parameters.

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