CN103961803A - Jaundice illumination treatment system and method on basis of multi-dimensional monitoring modes - Google Patents
Jaundice illumination treatment system and method on basis of multi-dimensional monitoring modes Download PDFInfo
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- CN103961803A CN103961803A CN201310034766.7A CN201310034766A CN103961803A CN 103961803 A CN103961803 A CN 103961803A CN 201310034766 A CN201310034766 A CN 201310034766A CN 103961803 A CN103961803 A CN 103961803A
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- 238000000034 method Methods 0.000 title claims abstract description 21
- 206010023126 Jaundice Diseases 0.000 title abstract description 11
- 238000005286 illumination Methods 0.000 title abstract description 5
- 238000001126 phototherapy Methods 0.000 claims abstract description 60
- 238000005516 engineering process Methods 0.000 claims abstract description 10
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- 230000001225 therapeutic effect Effects 0.000 abstract description 21
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 2
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- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 20
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Abstract
The invention relates to the field of jaundice illumination treatment. The problems that in the prior art, the therapeutic process of the jaundice disease is large in randomness and the effect is difficult to control are solved through establishment of a systematic control method in an illumination treatment process. According to the system and method, multiple monitoring submodules with a multi-dimensional monitoring function and a multi-wavelength phototherapy submodule with a multimode light-emitting function are created to improve treatment accuracy, and the monitoring feedback technology is combined to closely integrate the therapeutic effect with therapeutic schedules; controllability and usability of the phototherapy process are improved, clinic efficiency is improved, workloads of medical staff are relieved, and family medical treatment becomes possible thoroughly.
Description
Technical field
The present invention relates to jaundice light therapy field, set up the systematicness of light exposure treatment process and controlled and method.
Background technology
Neonatal jaundice is a kind of clinical common sign, and incidence rate is up to 60%～80%.When unconjugated bilirubin concentration surpasses 5～7mg/dl in blood, occur that the visible jaundice of naked eyes levies, therefore claim again hyperbilirubinemia.This disease of part can cause bilirubin encephalopathy, and severe patient case fatality rate is high, and survivor leaves sequela more.Therefore, newborn jaundice infant is carried out system monitoring and intervened is in time core and the key of prevention bilirubin encephalopathy, has important clinical meaning.
Light therapy, because of its noinvasive, the easy feature such as capable, effective, is the conventional means of working as preclinical therapy unconjugated hyperbilirubinemia.Its principle is that under the effect of light, the unconjugated bilirubin in infant blood changes water solublity isomer into, discharges afterwards with bile and urine.But in actual clinical, the effect of phototherapy therapy is subject to the impact of many factors.
Wherein, light source influence factor has: the parameters such as spectrum, radiant intensity and irradiated area.Wherein, the therapeutic effect of the blue light of wavelength 425～475nm and the green glow of 510～530nm has obtained clinical common recognition extensive use, and white light is also applied within the specific limits because contain above-mentioned two kinds of wavelength simultaneously; In addition, irradiation intensity is relevant with configuration with the structure of phototherapy apparatus with irradiated area.Existing patent, document are all confined to the exploitation relevant to light source and improvement, use single therapy light source in realization, and human camera is adjusted light source parameters.As the blue-light treatment blanket that patent CN102327672A is realized, adopt the blue light source of fixed wave length and intensity; The control therapeutic bed able to programme that patent CN102327671A applies for, part has realized the control to radiant intensity and area, and the switching between blue light and white light, and wherein white light only throws light on but not treats; The treatment blanket that patent CN2695024Y applies for, has realized the monitoring to infant body temperature in therapeutic process; The therapy equipment that patent CN2721134Y applies for, has realized the control to treatment time; The treatment lamp that patent CN201105098Y realizes, has realized manual control switch's control; The phototherapy lamp that patent CN201710827U applies for, has realized regularly and brightness regulation, i.e. so-called intensity control.
In fact, the formulation of clinical middle medical intervention scheme is important too.; before and after phototherapy and in process, by timing, detect TCB (percutaneous bilirubin) or TSB (total serum bilirubin), according to bilirubin concentration present situation and variation tendency in patient body; and according to related medical guide, medical worker formulates phototherapy scheme and judges phototherapy effect.Existing document all lacks the monitoring to the jaundice state of an illness in treatment, still needs medical worker to continue to follow the trail of and adjust therapeutic scheme.Also, realize phototherapy and be still at present blank with the solution that monitoring organically combines.
From the pathological characteristic of hyperbilirubinemia, the combination of phototherapy and monitoring exists real reasonability.First, the bilirubinic performance property of there are differences, due to human anatomic structure and sanguimotor physiological reason, bilirubin be distributed in whole body position and concentration different, so jaundice concentration is diversity at body surface, distribute, as shown in Figure 2.In clinical practice, comprise that the technology of aforementioned patent does not meet the demand that applies different illumination according to different parts, so there is larger optimization space in therapeutic effect.Secondly, bilirubin variation is in vivo dynamic.In phototherapy process, the bilirubin concentration in patient body will be dynamic change with therapeutic effect, equally also reflect the variation tendency of the state of an illness.Clinically, being limited by prior art and economic factor, is limited to the position of patient's examinations and number of times; Be limited to medical worker's workload and ability to work, the enforcement of therapeutic scheme and lagging behind sometimes the opportunity of adjustment.Therefore all there is larger room for improvement in current patented technology, aspect structure composed and mode of operation.
To sum up, create treatment and monitor the system organically combining and be aided with the novel lighting matching, take related medical guide simultaneously as according to setting up intelligentized feedback mechanism, can realize the Real-Time Monitoring of phototherapy effect and the optimal adjustment of parameter.Optimizing therapeutic effect, accelerating to there is stronger clinical meaning aspect therapeutic process; Also will reduce professional threshold, for promoting family's phototherapy, create conditions, to promoting medical system reform, produce social meaning simultaneously.
Summary of the invention
Target of the present invention is, physiological characteristics for hyperbilirubinemia of newborn, based on light exposure treatment technology and electron controls technology, provide a kind of and there is multidimensional Real-Time Monitoring, feed back and then control the therapy system of implementing multimode therapeutic scheme in good time, and in system-based, propose a set of basic operational approach.
The technical scheme of implementing is, according to bilirubin concentration monitoring result, according to a set of monitoring system of clinical treatment guide preset parameter enforcement treatment, as Fig. 1.The monitoring of concentration, based on multidimensional TCB technology,, by being distributed in the monitoring modular of a plurality of positions of patient body-surface, detects bilirubin concentration value and the variation tendency of each position in real time; The enforcement of light exposure treatment is based on multidimensional, multi-wavelength light source technology, on the patient whole body corresponding to monitoring location many groups of phototherapy modules with light sources with different wavelengths of arrangement respectively, the duration that module is luminous and wavelength are all controlled; The plan of therapeutic scheme is planted in control module, and according to the data of aforementioned monitoring modular, medical worker's preset corresponding parameter in control module is exported to control phototherapy module; The system that the enforcement of therapeutic scheme forms based on aforementioned each module, according to the feedback of monitoring numerical value, system regulates the output of phototherapy module by control module.In system, monitoring modular and phototherapy module all with control module physical connection; Monitoring modular is controlled and provide data to control module; The controlled execution command adapted thereto of phototherapy module.
Described control module is used for accepting user's (medical worker) data input, and according to the work of input control monitoring modular and phototherapy module; Meanwhile, control module is also for receiving data from monitoring modular; In addition, control module is informed (or warning) user in several ways by the content of Monitoring Data, therapeutic scheme, therapeutic outcome, comprises figure, word, sound, the voice mode of wired or wireless transmission; Foregoing supports user to carry out the function of filing, inquiry, printing equally.
Described monitoring modular is controlled by control module, in accordance with the bilirubin concentration data in instruction Real-time Collection patient body transmission.Monitoring modular comprises one group of submodule, and each submodule is positioned over respectively zones of different in patient body-surface (1～5 totally 5 regions, as Fig. 2), detects respectively and gather the data in each region.Because the quantity of submodule is most important to the judgement state of an illness, the effect that also determined enforcement is treated, thus recommend 5 above collection points (in Fig. 2,1 collection point is at least placed in each region), but any amount of collection point all belongs to the protection domain of this patent.
Described phototherapy module is controlled by control module, luminous to carry out light exposure treatment scheme in accordance with instruction.Phototherapy module is comprised of one group of submodule, and in body surface region as shown in Figure 2,1 monitoring submodule of every placement is corresponding at least one treatment submodule of placing all, with the skin area of ensuring coverage maximum, improves therapeutic effect.Each treatment submodule is comprised of a plurality of phototherapy unit respectively, as Fig. 3; Each phototherapy unit is comprised of white, green, blue 3 kinds of light sources, and each color light source is mutual/is spaced, as Fig. 4.Each phototherapy unit in phototherapy module is controlled respectively in the instruction that control module is sent, and comprises that whether luminous, the luminous duration of single source, luminous intensity be all controlled, and wherein luminous intensity can controlledly dynamically regulate continuously.
The treatment implementation and operation method of native system comprises 9 steps, as follows:
Step 0. is according to the sign of Fig. 2, and user (medical worker) is positioned over monitoring modular and phototherapy module correspondence at each position of patient body, and position and the quantity of wherein monitoring between submodule and phototherapy submodule are corresponding one by one;
Step 1. user (medical worker) inputs patient's basic condition by control module, comprise sex, body weight, premature labor time, race No. ID;
Step 2. user (medical worker) sets the control parameter of monitoring modular by control module, comprise chooser module, determines the position of being monitored of patient body, the renewal frequency of Monitoring Data, monitoring duration;
Step 3. user (medical worker) sets by control module project and the mode that Monitoring Data shows or transmits, to inform in time medical worker;
Step 4. user (medical worker) starts monitoring modular by control module;
Step 5. user (medical worker) obtains Monitoring Data by control module and consults patient's the state of an illness, comprises bilirubinic CONCENTRATION DISTRIBUTION situation, development trend;
Step 6. user (medical worker) sets the light source luminescent parameter in phototherapy module by control module, comprises, patient body is laid the luminous opportunity of phototherapy submodule, required wavelength (or wavelength combinations), scope, intensity, time; Whether intensity needs to adjust, the opportunity of adjustment, trend and scope; Whether wavelength needs to adjust, the opportunity of adjustment, scope.
Step 7. user (medical worker) sets treatment or warning limit value by control module, Real-time Obtaining certain monitored the bilirubinic concentration information that module detects, when surpassing limit value, extinguish corresponding treatment submodule.
Step 8. user (medical worker) sets project and the mode of Monitoring Data, treatment data show or transmission by control module, to inform in time medical worker.
The light exposure treatment that native system is implemented all exists for foundation with the real-time physical of jaundice in scope, intensity, time, and has realized the reasonable control to therapeutic process by feedback mechanism.Therefore, action effect of the present invention is objective, clear and definite.First, the formulation of therapeutic scheme and implement objective Data support and have clear and definite specific aim, therapeutic scheme meets pathology, the physiological feature of human body, contributes to obtain effective therapeutic outcome.That is, by multidimensional, monitor and multidimensional light exposure treatment, realized the diverse location at patient body-surface, apply the function of the illumination of different durations, varying strength, different wave length (or wavelength combinations).Secondly, development trend and therapeutic effect that medical worker can real-time tracking conditions of patients, and adjust in time as required therapeutic scheme.In addition, the monitoring of the feedback of system complete and alert notice mechanism, reduced medical worker's working strength and fault rate.
Accompanying drawing explanation
Fig. 1. the signal of therapy system framework
Fig. 2. human region is divided signal, take head as initial, and numeral is increased to 5 successively from 1
Fig. 3. the signal of phototherapy modular structure, each module is arranged in order and is formed by the phototherapy unit shown in a plurality of Fig. 4
The signal of Fig. 4 phototherapy cellular construction, each unit is comprised of the 3 mutual intervals of color light source
The specific embodiment
The realization of system, comprise control module, monitoring modular and phototherapy module realize respectively and for guiding the realization of the software of workflow.
The realization of control module is based in two kinds of modes, the one, utilize the MPU (Micro process unit) of embedded technology to realize, the 2nd, use personal computer to realize, on software, realize the restriction of various workflows, the management of the default and relevant information of parameter realizes and being connected with phototherapy module with monitoring modular respectively by wired or wireless mechanics of communication on hardware.
Monitoring modular utilizes the Skin Color Information of chromaticity transducer collection parts of body, and controlled and control module communication, realizes bilirubin in the detection of the CONCENTRATION DISTRIBUTION of health, thereby helps the judgement jaundice state of an illness.
The physics realization of phototherapy module has two kinds of methods, the one, based on the luminous LED of point, total white, green, blue three-color, each phototherapy submodule all adopts the individual LED alternately of most amounts, in module whole, form area source, and be covered in the position of required treatment; The 2nd, based on the luminous sidelight optical fiber (or entirely lighting optical fiber) of line, be that each phototherapy submodule adopts three three-color LED light sources, by three sidelight optical fiber, send wavelength light separately respectively, three optical fiber phase twisteds are made into cloth shape, form equally on the whole and light source be covered in treated position.Shades of colour in above-mentioned two kinds of methods all can be controlled respectively, and the whether luminous and time all realizes by the on-off circuit time, and luminous intensity realizes by current intensity Circuit tuning.
The using method of therapy system.With reference to the number mark in Fig. 2, will organize as required monitoring submodule and phototherapy submodule more and be covered in each position of patient body, and set up communication contact with control module; Medical worker, according to the method described in right 7, implements therapeutic scheme monitor treatment process by control module.Method is as follows,
Step 0. is according to the sign of Fig. 2, and user (medical worker) is positioned over monitoring modular and phototherapy module correspondence at each position of patient body, and position and the quantity of wherein monitoring between submodule and phototherapy submodule are corresponding one by one;
Step 1. user (medical worker) inputs patient's basic condition by control module, comprise sex, body weight, premature labor time, race No. ID;
Step 2. user (medical worker) sets the control parameter of monitoring modular by control module, comprise chooser module, determines the position of being monitored of patient body, the renewal frequency of Monitoring Data, monitoring duration;
Step 3. user (medical worker) sets by control module project and the mode that Monitoring Data shows or transmits, to inform in time medical worker;
Step 4. user (medical worker) starts monitoring modular by control module;
Step 5. user (medical worker) obtains Monitoring Data by control module and consults patient's the state of an illness, comprises bilirubinic CONCENTRATION DISTRIBUTION situation, development trend;
Step 6. user (medical worker) sets the light source luminescent parameter in phototherapy module by control module, comprises, patient body is laid the luminous opportunity of phototherapy submodule, required wavelength (or wavelength combinations), scope, intensity, time; Whether intensity needs to adjust, the opportunity of adjustment, trend and scope; Whether wavelength needs to adjust, the opportunity of adjustment, scope;
Step 7. user (medical worker) sets treatment or warning limit value by control module, Real-time Obtaining certain monitored the bilirubinic concentration information that module detects, when surpassing limit value, extinguish corresponding treatment submodule;
Step 8. user (medical worker) sets project and the mode of Monitoring Data, treatment data show or transmission by control module, to inform in time medical worker.
Claims (7)
1. a photosensitive agent, is characterized in that,
By three kinds of modules, formed, control module, monitoring modular and phototherapy module, wherein control module is 1 group, the quantity of latter two module is at least respectively 5 groups, therefore no matter can according to the state of an illness, be increased and decreased as required by medical worker, the quantity in practical application is how many, is all subject to this patent protection; Its logical relation is that the duty that the former arranges rear both modules as required by medical worker forms afterwards one-to-one relationship and is preset in each position of patient body by medical worker in quantity and spatial distribution between both modules; Work ultimate principle is to utilize monitoring modular from a plurality of positions of health real-time data collection, and make feedback action according to these data in good time, and then control multimode phototherapy module and implement treatment.
2. the control module as described in right 1, is characterized in that,
Based on embedded or computer software hardware technology; By the preset all kinds of clinical necessary informations of man-machine interaction interface, comprise the essential informations such as patient's individual and physiology, as sequence number, sex, race, body weight, height etc.; By man-machine interaction, control at any time or preset parameter implement to be controlled, realize the several functions of monitoring modular and phototherapy module, as control a plurality of monitoring modulars start and stop single or multiple module Collect jointly data wherein, and start and stop opportunity and acquisition time all controlled; Control a plurality of phototherapy modules start and stop single or multiple modules associating wherein luminous, and start and stop opportunitys, luminous intensity and fluorescent lifetime are all controlled; Logic corresponding relation based between patient information, the essential information comprising, monitoring parameter information and treatment control information, realize the management of information, as the monitoring of information, inquiry, filing and transmission; When monitoring parameter exceeds presetting range, start prompting or report to the police, to inform medical personnel; The display mode of aforementioned information, project and transmission means, project are all controlled.
3. the monitoring modular as described in right 1 and right 2, is characterized in that,
The quantity of monitoring modular is 5 groups of submodules, or increase and decrease as required; It is positioned over each position of patient body by medical personnel, wherein 1 group of monitoring submodule is arranged at each position, therefore claim multidimensional monitoring modular, its distributing position at human body submits to the physiological feature of blood circulation of human body, as shown in the number in Fig. 2, and be controlled by the control module described in right 2.
4. the method for work of the monitoring modular as described in right 1 and right 2, is characterized in that,
Monitoring modular is comprised of a plurality of submodules, and its monitoring feature is all controlled, whether comprises monitoring, the duration of monitoring.
5. phototherapy module as described in right 1 and right 2, is characterized in that,
The quantity of phototherapy module is 5 groups of submodules, or increase and decrease as required; Corresponding with installation position and the quantity of monitoring modular, be distributed in equally each position of health, its distributing position at human body is as shown in the number in Fig. 2, every group of light source forms by a plurality of phototherapy unit, each unit is comprised of white, green, blue 3 color light source, the mutual alternate combination pairing of each color light source, thus multimode phototherapy module claimed, and be controlled by the control module described in right 2; Every group of submodule can reach better effect while reaching 3 kinds of colors, and in realization, can select as required and reconfigure, but which kind of compound mode no matter, as increased, reducing color, the arrangement mode between color, is all subject to this patent protection.
6. the working method of the phototherapy module as described in right 1 and right 2, is characterized in that,
Every group of phototherapy submodule, forms by a plurality of phototherapy unit, and each unit forms by white, green, blue 3 color light source, and its luminous feature is all controlled, comprises whether luminous, luminous duration, luminous color scheme.
7. the design of the control system method of work as described in right 1 and right 2, is characterized in that the combination between following 9 steps or different step,
Step 0. is according to the sign of Fig. 2, and user (medical worker) is positioned over monitoring modular and phototherapy module correspondence at each position of patient body, and position and the quantity of wherein monitoring between submodule and phototherapy submodule are corresponding one by one;
Step 1. user (medical worker) inputs patient's basic condition by control module, comprise sex, body weight, premature labor time, race No. ID;
Step 2. user (medical worker) sets the control parameter of monitoring modular by control module, comprise chooser module, determines the position of being monitored of patient body, the renewal frequency of Monitoring Data, monitoring duration;
Step 3. user (medical worker) sets by control module project and the mode that Monitoring Data shows or transmits, to inform in time medical worker;
Step 4. user (medical worker) starts monitoring modular by control module;
Step 5. user (medical worker) obtains Monitoring Data by control module and consults patient's the state of an illness, comprises bilirubinic CONCENTRATION DISTRIBUTION situation, development trend;
Step 6. user (medical worker) sets the light source luminescent parameter in phototherapy module by control module, comprises, patient body is laid the luminous opportunity of phototherapy submodule, required wavelength (or wavelength combinations), scope, intensity, time; Whether intensity needs to adjust, the opportunity of adjustment, trend and scope; Whether wavelength needs to adjust, the opportunity of adjustment, scope;
Step 7. user (medical worker) sets treatment or warning limit value by control module, Real-time Obtaining certain monitored the bilirubinic concentration information that module detects, when surpassing limit value, extinguish corresponding treatment submodule;
Step 8. user (medical worker) sets project and the mode of Monitoring Data, treatment data show or transmission by control module, to inform in time medical worker.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214219A (en) * | 2015-11-03 | 2016-01-06 | 莫国良 | Full-automatic equipment for treating neonatal jaundice |
| CN105664372A (en) * | 2016-02-24 | 2016-06-15 | 广州美琳美健医疗科技有限公司 | Blue-light therapeutic instrument for jaundice detection |
| CN107308547A (en) * | 2017-06-20 | 2017-11-03 | 上海圭目机器人有限公司 | A kind of intelligent physical therapeutic system and physical therapy method based on Terahertz module |
| CN111434309A (en) * | 2019-01-11 | 2020-07-21 | 新加坡国立大学 | Sensor and system for neonatal jaundice monitoring and management |
| CN112930007A (en) * | 2021-01-31 | 2021-06-08 | 广东光阳电器有限公司 | Intelligent control method of health-care desk lamp |
| CN113975643A (en) * | 2021-10-21 | 2022-01-28 | 杭州英诺维科技有限公司 | Blue light box on-line monitoring method and blue light box on-line monitoring system |
| CN116211619A (en) * | 2021-12-03 | 2023-06-06 | 深圳市理邦精密仪器股份有限公司 | Nursing bed control method, device, medical equipment and system |
| US12233279B2 (en) | 2017-05-30 | 2025-02-25 | Icahn School Of Medicine At Mount Sinai | Device for photo-therapy and use thereof |
| CN119770865A (en) * | 2024-12-27 | 2025-04-08 | 四川必可明科技有限公司 | Phototherapy system and non-invasive treatment system |
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2013
- 2013-01-29 CN CN201310034766.7A patent/CN103961803A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105214219A (en) * | 2015-11-03 | 2016-01-06 | 莫国良 | Full-automatic equipment for treating neonatal jaundice |
| CN105664372A (en) * | 2016-02-24 | 2016-06-15 | 广州美琳美健医疗科技有限公司 | Blue-light therapeutic instrument for jaundice detection |
| CN105664372B (en) * | 2016-02-24 | 2018-06-19 | 广州美琳美健医疗科技有限公司 | Jaundice detects blue-light treatment instrument |
| US12233279B2 (en) | 2017-05-30 | 2025-02-25 | Icahn School Of Medicine At Mount Sinai | Device for photo-therapy and use thereof |
| CN107308547A (en) * | 2017-06-20 | 2017-11-03 | 上海圭目机器人有限公司 | A kind of intelligent physical therapeutic system and physical therapy method based on Terahertz module |
| CN111434309A (en) * | 2019-01-11 | 2020-07-21 | 新加坡国立大学 | Sensor and system for neonatal jaundice monitoring and management |
| CN112930007A (en) * | 2021-01-31 | 2021-06-08 | 广东光阳电器有限公司 | Intelligent control method of health-care desk lamp |
| CN113975643A (en) * | 2021-10-21 | 2022-01-28 | 杭州英诺维科技有限公司 | Blue light box on-line monitoring method and blue light box on-line monitoring system |
| CN113975643B (en) * | 2021-10-21 | 2024-04-16 | 杭州英诺维科技有限公司 | Online monitoring method and online monitoring system for blue light box |
| CN116211619A (en) * | 2021-12-03 | 2023-06-06 | 深圳市理邦精密仪器股份有限公司 | Nursing bed control method, device, medical equipment and system |
| CN119770865A (en) * | 2024-12-27 | 2025-04-08 | 四川必可明科技有限公司 | Phototherapy system and non-invasive treatment system |
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Application publication date: 20140806 |