CN103845816A - Radiotherapy system and real-time monitoring method thereof - Google Patents
Radiotherapy system and real-time monitoring method thereof Download PDFInfo
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Abstract
The invention discloses a radiotherapy system and a real-time monitoring method thereof. The radiotherapy system comprises a radiotherapy head, a monitoring control table and a therapeutic bed, wherein a ray detection device is further arranged on the position opposite to the radiotherapy head, receives therapeutic beams from the radiotherapy head and outputs image imaging information to the monitoring control table; the monitoring control table is connected with and controls the radiotherapy head and/or the therapeutic bed. According to the radiotherapy system and the real-time monitoring method thereof, real-time imaging is achieved by means of the ray detection device and the therapeutic beams, a therapeutic scheme is adjusted or the therapeutic process is controlled in real time to achieve precise radiotherapy. Accordingly, it is guaranteed that therapy and monitoring are carried out at the same time, and extra dose deposit caused by additional imaging ray beams is avoided.
Description
Technical field
The present invention relates to a kind of medical treatment device and method for supervising thereof, relate in particular to a kind of radiotherapy system and method for real-time monitoring thereof.
Background technology
As an important means of oncotherapy, radiocurable ultimate principle is by radiation exposure tumor, causes the inside infringement of tumor cell, the active procedure of blocking-up cell, stop the growth division of tumor cell, until cause it finally dead, thus reach the object for the treatment of.Radiotherapy is mainly for some to the recipient tumor of ray, and such as nasopharyngeal carcinoma, mastadenoma, esophageal carcinoma, uterus carcinoma etc., to the often poor effect of tumor of the not strong tumor of susceptibility and recurrence.Even if to recipient tumor, conventionally also need to optimize irradiation treatment scheme to reduce side effect.In order to reduce the infringement of radiation to tumor normal surrounding tissue, the treatment technology that some are advanced, as 3 dimensional conformal radiation therapy (conformal radiation therapy, CRT), intensity modulated radiation therapy (Intensitymodulated radiation therapy, IMRT) etc. is widely used in clinical treatment.The enforcement of all these technology all needs to know in advance the relevant informations such as position, size and the distribution of tumor, and this just need to utilize CT, MRI, X-ray, the image means such as ultrasonic to provide.In conventional 3 dimensional conformal radiation therapy, first by the shape of multi-diaphragm collimator constraint wire harness, make it to coincide with the tumor cross section of this angle, reduce the unnecessary radiation that normal structure is subject to.Further, radiation beams, from different angular illumination tumors, deposits thereby obtain desirable dosage.Wherein, normal surrounding tissue is because irradiated scope increases, and suffered dosage is disperseed greatly, and its biological damage also decreases.The intensity modulated radiation therapy growing up on this basis is further modulated for the radiation in irradiation field, regulates radiation beam, thereby obtain more preferably dose distribution in sequential and wire harness profile intensity.The side effect bringing in order further to alleviate radiation, consider that Normocellular repair ability is better than tumor cell, conventionally adopt what is called to cut apart radiotherapy technology, only irradiate a certain proportion of dosage at every turn, irradiated several times the deposition of predetermined close at tumor region.Irradiate the intermission, normal structure can be repaired the infringement that radiation brings.
Human body is a dynamical system, and accurate radiotherapy must be considered the motion of organizing in therapeutic process, and such as heart and lung etc. be motion periodically, and the impact that transports for dosage of patient's motion itself.For radiation dose is transported to target area exactly, motion that will monitoring human, knows its real-time status.Existing two class monitoring methods, the one, outside treatment bundle, introduce again an extra one-tenth video beam (for example KeV energy section X-ray) and monitor, owing to monitoring and treating and separately carry out, this mode can not provide real real time imaging conventionally, and frequently uses KeV monitoring beam also can bring unnecessary extra dose infringement to patient.The 2nd, between treatment Shu Xulie, insert into video beam so that the information of body state to be provided, and survey the radiation profile that penetrates human body, i.e. radial projection image on the opposite of human body.This method imaging process and therapeutic process also separately carry out, and real real time information also cannot be provided, and normal structure also can be subject to extra radiation dose because of imaging.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of radiotherapy system and method for real-time monitoring thereof, can ensure that therapeutic imaging synchronously carries out, and the extra dose deposition of avoiding additional imaging ray bundle to bring.
The present invention solves the problems of the technologies described above the technical scheme adopting to be to provide a kind of radiotherapy system, comprise radiotherapy head, MonitorConsole and therapeutic bed, wherein, relative position at described radiotherapy head is also provided with ray detecting device, described ray detecting device receives the treatment bundle from radiotherapy head, and output image image-forming information is given described MonitorConsole; Described MonitorConsole connects and controls described radiotherapy head and/or therapeutic bed.
Above-mentioned radiotherapy system, wherein, the radioactive source of described radiotherapy head is x-ray source, electron source, synchrotron radiation source or neutron source.
Above-mentioned radiotherapy system, wherein, described ray detecting device is real-time ray density distribution detector.
The present invention is the method for real-time monitoring that solves the problems of the technologies described above the technical scheme adopting and be to provide a kind of above-mentioned radiotherapy system, wherein, comprises the steps: a) to obtain treatment Shu Xulie, and implements in order a treatment bundle; B) adjust described treatment bundle, make its focus region that aims at the mark; C) the treatment Shu Xulie of described ray detecting device reception radiotherapy head passes the ray behind target focus region, and carries out realtime imaging; D) described image-forming information outputs to described MonitorConsole, and described MonitorConsole compares the position shape of real-time projection imaging and the position shape that is predetermined to be picture, controls and adjust in real time described radiotherapy head and/or therapeutic bed.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described step is obtained the dispensing order to treatment Shu Xulie after treatment Shu Xulie in a) or/and interval is adjusted.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described number, dosage size and the dosage that comprises adjustment treatment beam line to treating the adjustment of Shu Xulie is cut apart.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described step is adjusted treatment bundle in b) and is comprised position and the shape of adjusting treatment bundle; The position of described adjustment treatment bundle comprises incoming position and the incident angle of adjusting treatment beam line; The shape of described adjustment treatment bundle comprises beam shape and the wire harness intensity distributions of adjusting treatment beam line.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, when treatment bundle is adjusted, also comprises by the pulse width of adjustment for the treatment of bundle the deposit dose of adjusting front and back is remained unchanged.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described steps d) in only to the key position treatment beam ratio that contains tumor characteristic information compared with image space form variations; Described MonitorConsole completes imaging comparison and the adjustment of successive treatment bundle of current key position treatment bundle before the next key position treatment of transmitting bundle.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described tumor characteristic information comprises tumor boundaries, tumor character shape, bone edge, calcified plaque and/or signature thing.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described steps d) correct treatment deviation by adjusting radiotherapy head and/or therapeutic bed.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described steps d) also comprise: described MonitorConsole compares real-time projection imaging position shape and predetermined image space shape, in the time of position shape generation deviation, adjust radiotherapy head or/and therapeutic bed, until projection imaging position shape is consistent with predetermined image space shape; After position shape is consistent, dosage that deviation is caused changes to be converted, and relatively whether deposit dose reaches predetermined close, as does not reach, and continues to irradiate lonizing radiation, prepares next treatment bundle after reaching predetermined close.
The method for real-time monitoring of above-mentioned radiotherapy system, wherein, described adjustment radiotherapy head comprises position, cross sectional shape, incident angle or the pulse width of adjustment for the treatment of beam line.
The present invention contrasts prior art following beneficial effect: radiotherapy system provided by the invention and method for real-time monitoring thereof, the ray detecting device arranging is surveyed the treatment beam that penetrates human body, provide real-time treatment image, after contrast therapy plan, by controlling platform, treatment process or therapeutic scheme are controlled in real time and adjusted, therefore, the present invention is without adding additionally independently imaging device, realize the Real-Time Monitoring in therapeutic process, thereby guarantee treatment and imaging are synchronously carried out, and the extra dose deposition of avoiding additional imaging ray bundle to bring.
Brief description of the drawings
Fig. 1 is radiotherapy system schematic diagram of the present invention;
Fig. 2 is the real-time monitoring main flow schematic diagram of radiotherapy system of the present invention;
Fig. 3 is the Real-Time Monitoring treatment schematic flow sheet for the treatment of bundle in embodiment of the present invention radiotherapy system;
Fig. 4 is the embodiment of the present invention treatment serial fragment of bundle and corresponding tumor feature schematic diagram thereof.
In figure:
1 radiotherapy head 2 MonitorConsole 3 therapeutic bed
4 ray detecting device 5 patient's 6 tumor boundaries
7 bone edge 8 calcified plaque 9 signature things
Detailed description of the invention
Below in conjunction with drawings and Examples, the invention will be further described.
Fig. 1 is radiotherapy system schematic diagram of the present invention.
Refer to Fig. 1, radiotherapy system provided by the invention comprises radiotherapy head 1, MonitorConsole 2, therapeutic bed 3 and ray detecting device 4, ray detecting device 4 and radiotherapy head 1 are oppositely arranged, ray detecting device 4 receives the real-time projection imaging for the treatment of Shu Jinhang of exporting from radiotherapy head 1, and output image image-forming information is to MonitorConsole 2; MonitorConsole 2 connects and controls described radiotherapy head 1 and/or therapeutic bed 3, receives from the monitoring image of ray detecting device 4 and adjusts in real time radiotherapy head and/or therapeutic bed 3 precisely treatments of realization radiation.The radioactive source of radiotherapy head 1 can be selected x-ray source, electron source, synchrotron radiation or neutron source.Ray detecting device 4 can be selected flat panel detector or some other high-energy ray sniffer.
Radiotherapy system provided by the invention utilizes the system and method for the treatment of Shu Zishen imaging Real-Time Monitoring tumor motion and therapeutic process in actual therapeutic scheme, by regulating and optimizing the dispensing order for the treatment of bundle used in therapeutic process and size and the shape of corresponding treatment bundle irradiation field, realize real Real-Time Monitoring.In addition, the present invention is easy to implement, and cost is relatively low, thoroughly eliminated simultaneously due in existing scheme observation process due to the extra dose deposition that need to add imaging ray bundle (KeV or MeV) and bring.
Fig. 2 is the real-time monitoring main flow schematic diagram of embodiment of the present invention radiotherapy system.
Please continue referring to Fig. 2, the concrete steps performed of radiotherapy system of the present invention is as follows:
Step S201: obtain treatment bundle series on the basis of formulating suitable treatment regimens, and implement in order a treatment bundle.
Step S202: the position shape to treatment bundle is adjusted, makes treatment restraint the focus region that aims at the mark; The position of adjusting treatment bundle comprises incoming position and the incident angle of adjusting treatment beam line; The shape of adjusting treatment bundle comprises beam shape and the wire harness intensity distributions of adjusting treatment beam line.
Step S203: in therapeutic process, the ray of the treatment bundle that ray detecting device 4 receives radiotherapy head 1 after through target focus region, and carry out realtime imaging, motion and the variation of the tumor within the scope of can Real Time Observation treatment bundle.In this scheme, the treatment Shu Benshen that penetrates human body has carried the information that inside of human body tissue comprises tumor feature, utilize ray detecting device 4 can extract contained information, thus do not need except the extra imaging ray bundle treatment bundle with and the additional dose that brings.And the imaging overlay area of each treatment bundle is generally all much smaller than routine diagnosis imaging region, thereby the also reduction greatly of the data volume that need to read, thereby greatly improves speed, realizes Real-Time Monitoring.The energy for the treatment of bundle is easy to saturated, and ray detecting device 4 can utilize the technological means such as shutter or attenuation block control light exposure.
Step S204: described image-forming information outputs to described MonitorConsole 2, MonitorConsole 2 compares the position shape of real-time projection imaging and the position shape that is predetermined to be picture, controls and adjust in real time radiotherapy head 1 and/or therapeutic bed 3.Before treatment, can regulate the dispensing order of the treatment Shu Xulie adopting in existing therapeutic scheme, make to treat accordingly Shu Xulie and can meet the requirement of real-time coverage goal focus region (being generally the tumor that contains characteristic information, a part or its marginal area of tumor): in whole dosage delivery process, every certain time interval just have can coverage goal focus region treatment bundle exist; If existing treatment Shu Xulie can not meet the requirement of covering in real time completely, can be as required, further regulate and optimize existing therapeutic scheme; Comprise that number, dosage size and the dosage of adjusting ray cuts apart, produce the new new treatment Shu Xulie that meets real-time coverage requirement, make the ray detecting device 4 can realtime imaging and keep synchronizeing with therapeutic process.The dosage depositing can be carried out Real-Time Monitoring and accurately be controlled by the pulse width of adjustment for the treatment of bundle, guarantees that dosage does not exceed standard, and makes to treat the total deposit dose in Shu Xulie adjustment front and back by the pulse width of adjustment for the treatment of bundle and remains unchanged.After treatment starts, MonitorConsole 2 compares real-time projection imaging position shape and predetermined image space shape, as occurrence positions form variations, provide Real-time Feedback, and adjust in time treatment beam wire shaped and adjust radiotherapy head 1 or/and correct in real time the position of therapeutic bed 3.Thereby as much as possible radiation dose is deposited on to tumor region, reduces the radiation damage for normal structure.
As shown in Figure 3, treatment starts, and MonitorConsole 2 compares real-time projection imaging position shape and predetermined image space shape, as position shape generation deviation, adjust radiotherapy head 1 or/and therapeutic bed 3, until the position shape of projection imaging is consistent with the position shape that is predetermined to be picture; After position shape is consistent, the dosage that deviation is caused is converted, and relatively whether deposit dose reaches predetermined close, as does not reach, and continues to irradiate lonizing radiation, prepares next treatment bundle after reaching predetermined close; Thereby realize precisely treatment of radiation, in figure, N is natural number.
For speed up processing, can be only to the treatment beam ratio that contains tumor characteristic information compared with image space deviation; Described MonitorConsole 2 is treated imaging comparison and the adjustment of successive treatment bundle of bundle as long as complete current key position before the next key position treatment of transmitting bundle, thereby also can reduce ray detecting device 4 imaging requirement of real-times.Tumor characteristic information refers to any information that identification can be provided, comprise irregular edge, with respect to the position of bone and/or some calcified plaques, strengthen position or the marker that some are external and built-in etc. of structures with respect to some contrasts such as blood vessel trachea.Refer to Fig. 4, in figure, the first row is cross sectional shape and the size for the treatment of bundle, and the second row is tumor shape and the feature in corresponding roentgenization open country.Obviously, the treatment beam ratio of having reacted tumor feature is evenly distributed in treatment sequence, and such treatment area of beam shape is corresponding the feature of tumor respectively, as border and the tumor boundaries 6 of n and n+2 treatment bundle match, the bone edge 7 on the border of n+3 treatment bundle and tumor side is similar, and the border of n+5 treatment bundle and the structural similarity of calcified plaque 8 and/or signature thing 9, n is natural number.In therapeutic process, monitor the treatment bundle that these have reacted tumor feature, in the time finding that treating the tumor feature of restrainting in irradiation field has visibility point to change, the compensated position that takes appropriate measures changes, this tumor region is got back in successive treatment bundle irradiation field, thereby dosage can be deposited in interested tumor effectively.
In sum, radiotherapy system provided by the invention and method for real-time monitoring thereof, utilize treatment Shu Jinhang realtime imaging completely, and adjust in real time position deviation and realize precisely treatment of radiation, thereby ensure that therapeutic imaging synchronously carries out, and the extra dose deposition of avoiding additional imaging ray bundle to bring.Concrete advantage is as follows: the imaging system of 1) relatively simplifying, reduce the difficulty that operation is controlled, and without adding additionally independently imaging device, implementation cost also reduces greatly.2) realized the Real-Time Monitoring in therapeutic process, and the result of monitoring can be read fast, provide real-time feedback signal to control treatment process or corresponding adjustment therapeutic scheme, comprise the position of pendulum again to patient, position, cross sectional shape and the angle etc. of adjustment for the treatment of head output radiation beam.3) the dosage deposition of optimizing, has eliminated the additional dose that extra imaging ray band comes, and ensure that the dosage for the treatment of bundle can be deposited on tumor region effectively, and in normal structure, the deposition of extra dose can be ignored simultaneously.
Although the present invention discloses as above with preferred embodiment; so it is not in order to limit the present invention, any those skilled in the art, without departing from the spirit and scope of the present invention; when doing a little amendment and perfect, therefore protection scope of the present invention is worked as with being as the criterion that claims were defined.
Claims (13)
1. a radiotherapy system, comprise radiotherapy head (1), MonitorConsole (2) and therapeutic bed (3), it is characterized in that, also be provided with ray detecting device (4) at the relative position of described radiotherapy head (1), described ray detecting device (4) receives the treatment bundle from radiotherapy head (1), and output image image-forming information is given described MonitorConsole (2); Described MonitorConsole (2) connects and controls described radiotherapy head (1) and/or therapeutic bed (3).
2. radiotherapy system as claimed in claim 1, is characterized in that, the radioactive source of described radiotherapy head (1) is x-ray source, electron source, synchrotron radiation source or neutron source.
3. radiotherapy system as claimed in claim 1, is characterized in that, described ray detecting device (4) is real-time ray density distribution detector.
4. a method for real-time monitoring for radiotherapy system as claimed in claim 1, is characterized in that, comprises the steps:
A) obtain treatment Shu Xulie, and implement in order a treatment bundle;
B) adjust described treatment bundle, make its focus region that aims at the mark;
C) the treatment Shu Xulie of described ray detecting device (4) reception radiotherapy head (1) passes the ray behind target focus region, and carries out realtime imaging;
D) described image-forming information outputs to described MonitorConsole (2), described MonitorConsole (2) compares the position shape of real-time projection imaging and the position shape that is predetermined to be picture, controls and adjust in real time described radiotherapy head (1) and/or therapeutic bed (3).
5. the method for real-time monitoring of radiotherapy system as claimed in claim 4, is characterized in that, described step is obtained the dispensing order to treatment Shu Xulie after treatment Shu Xulie in a) or/and interval is adjusted.
6. the method for real-time monitoring of radiotherapy system as claimed in claim 5, is characterized in that, described number, dosage size and the dosage that comprises adjustment treatment beam line to treating the adjustment of Shu Xulie is cut apart.
7. the method for real-time monitoring of radiotherapy system as claimed in claim 4, is characterized in that, described step is adjusted treatment bundle in b) and comprised position and the shape of adjusting treatment bundle; The position of described adjustment treatment bundle comprises incoming position and the incident angle of adjusting treatment beam line; The shape of described adjustment treatment bundle comprises beam shape and the wire harness intensity distributions of adjusting treatment beam line.
8. the method for real-time monitoring of the radiotherapy system as described in claim 4 or 5, is characterized in that, when treatment bundle is adjusted, also comprises by the pulse width of adjustment for the treatment of bundle the deposit dose of adjusting front and back is remained unchanged.
9. the method for real-time monitoring of radiotherapy system as claimed in claim 4, is characterized in that, described steps d) in only to the key position treatment beam ratio that contains tumor characteristic information compared with image space form variations; Described MonitorConsole (2) completes imaging comparison and the adjustment of successive treatment bundle of current key position treatment bundle before the next key position treatment of transmitting bundle.
10. the method for real-time monitoring of radiotherapy system as claimed in claim 9, is characterized in that, described tumor characteristic information comprises tumor boundaries, tumor character shape, bone edge, calcified plaque and/or signature thing.
The method for real-time monitoring of 11. radiotherapy systems as claimed in claim 4, is characterized in that, described steps d) correct treatment deviation by adjusting radiotherapy head (1) and/or therapeutic bed (3).
The method for real-time monitoring of 12. radiotherapy systems as claimed in claim 4, it is characterized in that, described steps d) also comprise: described MonitorConsole (2) compares real-time projection imaging position shape and predetermined image space shape, in the time of position shape generation deviation, adjust radiotherapy head (1) or/and therapeutic bed (3), until projection imaging position shape is consistent with predetermined image space shape; After position shape is consistent, dosage that deviation is caused changes to be converted, and relatively whether deposit dose reaches predetermined close, as does not reach, and continues to irradiate lonizing radiation, prepares next treatment bundle after reaching predetermined close.
The method for real-time monitoring of 13. radiotherapy systems as described in claim 11 or 12, is characterized in that, described adjustment radiotherapy head (1) comprises position, cross sectional shape, incident angle or the pulse width of adjustment for the treatment of beam line.
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