CN1038181C - One-step process for producing polyvinyl pyrrolidone-iodine aerosol - Google Patents
One-step process for producing polyvinyl pyrrolidone-iodine aerosol Download PDFInfo
- Publication number
- CN1038181C CN1038181C CN94114287A CN94114287A CN1038181C CN 1038181 C CN1038181 C CN 1038181C CN 94114287 A CN94114287 A CN 94114287A CN 94114287 A CN94114287 A CN 94114287A CN 1038181 C CN1038181 C CN 1038181C
- Authority
- CN
- China
- Prior art keywords
- aerosol
- iodine
- complexation
- ethanol
- polyvinylpyrrolidone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000011630 iodine Substances 0.000 title claims abstract description 18
- 229910052740 iodine Inorganic materials 0.000 title claims abstract description 18
- 239000000443 aerosol Substances 0.000 title claims abstract description 16
- 238000000034 method Methods 0.000 title claims abstract description 12
- 229920002554 vinyl polymer Polymers 0.000 title claims description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 26
- 238000010668 complexation reaction Methods 0.000 claims abstract description 14
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims abstract description 7
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims abstract description 7
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims abstract description 7
- 238000001914 filtration Methods 0.000 claims abstract description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 18
- 238000012856 packing Methods 0.000 claims description 4
- 238000000605 extraction Methods 0.000 claims 1
- 239000012467 final product Substances 0.000 claims 1
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 10
- 238000004519 manufacturing process Methods 0.000 abstract description 9
- 238000005265 energy consumption Methods 0.000 abstract description 3
- 238000010438 heat treatment Methods 0.000 abstract description 3
- 230000000536 complexating effect Effects 0.000 abstract description 2
- 238000010992 reflux Methods 0.000 abstract description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 7
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 239000003814 drug Substances 0.000 description 4
- 238000001291 vacuum drying Methods 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 210000004877 mucosa Anatomy 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000000829 suppository Substances 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000000643 oven drying Methods 0.000 description 1
- -1 polyethylene ketopyrrolidine Polymers 0.000 description 1
- 229910052573 porcelain Inorganic materials 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000010409 thin film Substances 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a one-step method for producing a polyvinylpyrrolidone-iodine solution aerosol. Polyvinylpyrrolidone and iodine are respectively dissolved in ethanol, and are placed in a complexation pot, and water-insoluble carriers and isopropyl ethanol are added after heating, refluxing and complexing, so the aerosol is obtained through filtration and split charging. The aerosol produced by the method has the advantages for decreasing investment cost for equipment by 50%, saving 75% of energy consumption, increasing 6 to 7 times of productive efficiency and raising the stability of the aerosol, and the aerosol can quickly form a disinfection film to ensure disinfection quality.
Description
The present invention relates to a kind of production method of polyvinyl pyrrolidone-iodine aerosol.
Povidon iodine was succeeded in developing by Beller etc. in nineteen fifty-five, and by German BasF company at first Application and Development recorded by state's pharmacopeia such as American and Britain, morals so far in clinical, in 1990 two ones of version of China's pharmacopeia is also recorded.This medicine belongs to second filial generation Operand, the sterilizing effect is strong, long action time, nontoxic, non-stimulated, safe and reliable, replaced other disinfectant abroad gradually, be widely used in the sterilization of skin, mucosa, wound, body cavity, its dosage form has aqueous pharmaceutical, aerosol abroad, contains the agent of coughing, ointment, gel, suppository etc., and China has recorded solution, ointment, suppository.Aerosol can be advantageously used in the sterilization of skin, mucosa, wound, can locally form uniform betadin thin film after the use, plays a protective role.
At present, the conventional production methods of polyvinyl pyrrolidone-iodine aerosol, be that polyvinylpyrrolidone and iodine are used chloroform (or ethanol) dissolving respectively, in the complexation still, carry out complexation, reclaim chloroform or ethanol blowing then, the dense magma of povidon iodine is put porcelain dish, through the vacuum drying oven drying, pulverize, get crude drug.Utilize carrier solvents such as water, ethanol, propylene glycol that crude drug is dissolved then, carry out ingredients again, stir evenly, filter packing.Obviously, existing production method complex manufacturing, use equipment is many, and energy consumption is big.
The object of the present invention is to provide a kind of one-step process for producing, save vacuum drying, solvent recovery and treatment facility, and reduce production process and equipment investment and save the energy.
Technical solution of the present invention in order to achieve the above object realizes in the following way.Polyvinylpyrrolidone and iodine are used dissolve with ethanol respectively, and it is complete to complexation to put complexation still reflux, and add the carrier fluid isopropyl alcohol afterwards and stir evenly, after filtration, packing.
Characteristics of the present invention are from throwing raw material, finishing in a complexation still continuously through complexation, ingredients.In order to realize this one-step method process route, the carrier intersolubility that solvent that uses in the time of just must making complexation and aerosol use is good, and carrier must guarantee that also the effective ingredient povidon iodine of aerosol has best stability.To the codissolved solvent of complexation material polyethylene ketopyrrolidine and iodine select ethanol and chloroform all can, but consider again can with the mutual coordination of carrier, so adopt ethanol to do complexing solvent.
Adopt water-insoluble isopropyl alcohol to do carrier on the other hand, under the lucifuge condition, make povidon iodine can obtain good stable, and muddy property of isopropyl alcohol is good, form mocromembrane sterilization face very soon, thereby guarantee reliable Disinfection Effect when shortening disinfecting time at skin surface.
This one-step process for producing is compared with traditional production method and is had the following advantages:
1, this production technology is saved vacuum drying, solvent recovery and treatment facility, therefore, can reduce equipment investment 50%.
2, this method only needs 8～10 hours from being dosed into finished product, and traditional handicraft needs 2～3 days, and production efficiency can improve 6～7 times.
3, because of saving the vacuum drying operation, this method only needs the energy consumption of traditional method 1/4.
4, this method adopts isopropyl alcohol to do carrier, does the carrier liquid medicine stability than water or ethanol and is much improved, and this product is deposited (lucifuge, sealing) naturally and only fallen 10% in 2 years, and under the same conditions with water, ethanol be carrier its degrade more than 40% 18% respectively.
5, medicinal liquid of the present invention is sprayed on skin surface, forms rapidly the sterilization mocromembrane in 25～50 seconds, and water to be the aerosol of carrier formed the sterilization mocromembrane through 3～6 minutes, the aerosol of ethanol carrier needed 45～90 seconds to form the sterilization mocromembrane, so this product has improved sterilisation quality.
Further specify technical solution of the present invention in conjunction with the embodiments.
1, with polyvinylpyrrolidone and ethanol with 4.5～5: the ratio of 1 (weight ratio) drops in the complexation still, starts agitator, is heated to polyvinylpyrrolidone all after the dissolving, stops heating its temperature is reduced to below 65 ℃.
2, then with iodine: the dissolved iodohydrin liquid of ethanol=1: 4.8～5.2 ratios is to be heated to backflow in 4.88～4.8: the 1 adding complexation still by the rate of charge of polyvinylpyrrolidone and iodine, refluxed 3～4 hours, extracting backflow does not have pink to be faint yellow is that complexation is finished, and stops heating.
3, complex is cooled to 35～40 ℃ naturally after, the isopropyl alcohol that adds 100 times of povidon iodine amounts (weight) stirs evenly, and filters packing.
Claims (1)
1, a kind of one-step process for producing polyvinyl pyrrolidone-iodine aerosol, polyvinylpyrrolidone and iodine are used dissolve with ethanol respectively, put in the complexation still and heat, be back to the extraction backflow and be faint yellow, make complexation complete, it is characterized in that: after complex was reduced to 35～40 ℃ naturally, the isopropyl alcohol that adds 100 times of povidon iodine weight stirred evenly, and packing after filtering gets final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94114287A CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94114287A CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1108928A CN1108928A (en) | 1995-09-27 |
| CN1038181C true CN1038181C (en) | 1998-04-29 |
Family
ID=5037178
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN94114287A Expired - Fee Related CN1038181C (en) | 1994-12-28 | 1994-12-28 | One-step process for producing polyvinyl pyrrolidone-iodine aerosol |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1038181C (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI289511B (en) | 2004-11-22 | 2007-11-11 | Canon Kk | Method of manufacturing liquid discharge head, and liquid discharge head |
| CN111358807B (en) * | 2020-04-01 | 2021-04-13 | 赵莹 | Nano-silver modified complex iodine composite dry powder disinfection aerosol and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0342269A2 (en) * | 1988-05-20 | 1989-11-23 | Sunstar Kabushiki Kaisha | Iodine microbiocide composition |
-
1994
- 1994-12-28 CN CN94114287A patent/CN1038181C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0342269A2 (en) * | 1988-05-20 | 1989-11-23 | Sunstar Kabushiki Kaisha | Iodine microbiocide composition |
Non-Patent Citations (1)
| Title |
|---|
| 《药剂辅料大全》第一版 1993.3.1 罗明生，高天惠主编;四川科技出版社 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1108928A (en) | 1995-09-27 |
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| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C06 | Publication | ||
| PB01 | Publication | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |