CN103816006A - Non-implantation equipment for stimulating blind people's visual perception through human body surface - Google Patents
Non-implantation equipment for stimulating blind people's visual perception through human body surface Download PDFInfo
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Abstract
The invention discloses non-implantation equipment for stimulating blind people's visual perception through the human body surface. The equipment comprises a master control module, an input module, at least one stimulating current generating module and an output module. The input module is connected to the master control module and used for receiving the a setting signal related to the frequency and/or amplitude of current input by a user. Each stimulating current generating module is connected to the master control module and used for generating at least one group of stimulating current under the control of the master control module, wherein the stimulating current is superposition of low-frequency pulse current with low-frequency pulse current or superposition of low-frequency pulse current with medium-frequency pulse current. The output module is connected to each stimulating current generating module and comprises a plurality groups of non-implantation electrodes which are in contact with the human body surface. The stimulating current is output from the electrodes and stimulates blind people to generate photoreception through the body surface. The equipment is safe, reliable and low in cost.
Description
Technical Field
The invention relates to the technical field of biomedical engineering, in particular to a non-implanted device for stimulating the visual perception of blind people through the body surface of a human body.
Background
About 90% of the information that humans know of the outside world is provided visually, and normal complete vision results from: the optical system of the eye images an external object on the retina, the photoreceptor cells on the retina convert image signals into bioelectricity signals, the bioelectricity signals are conducted to the cerebral visual cortex through the visual nerve fibers after primary processing is carried out on the cell membrane neural network, and the cerebral visual cortex processes the obtained bioelectricity signals again and senses the bioelectricity signals to generate vision. Injury or disease to any one of the visual pathways can lead to blindness, for example: retinitis pigmentosa, macular degeneration, blindness caused by severe amblyopia and other diseases or blindness caused by trauma. According to WHO1973 International Standard for Low-and Blind grading (best corrected for Vision): 3-grade blindness is less than 0.05-0.02, or the radius of vision is less than 10 degrees; 4-level blindness is less than 0.02-light sensation, or the radius of vision is less than 5 degrees; grade 5 blind no light feel.
Among the many treatments, the scheme of electrically stimulating the remaining visual cells of the retina using an implantable chip and electrodes enables the patient's vision to be restored to some extent. There are 4 schemes for stimulating the visual cortex, optic nerve, retina and subretinal space, depending on the position of the implanted electrode. The principle is that a visual electric signal is artificially simulated and is connected with a fine visual system of a human body to carry out direct electrical stimulation conduction, so that the visual cortex generates excitation similar to that caused by light stimulation on retina, and effective phosphenes are stimulated. For example, the chinese patent application No. 200610025215.4 discloses an implantable sheet-type optic nerve micro-stimulation electrode, which stimulates optic nerve fibers, the optic nerve fibers conduct the stimulation current generated by the stimulator to the optic cortex, so that the optic cortex generates the excitation similar to that generated after the retina is stimulated by light, thereby generating the phosphenes, and the potential of the optic nerve fibers can be recorded. The chinese patent application No. 200910197192.9 discloses a pseudoscopic vision simulation generation device and method, which can obtain a simulation result close to an actual situation and can meet the requirements of a multi-parameter experiment. The master thesis for the research of the microelectrode for repairing the retina designs the active flexible retina and the optic nerve stimulation electrode which are implanted for a long time, and the electrode has stable property and good biocompatibility, can work for a long time and is not easy to be corroded by body fluid. However, in effect, the above-mentioned implanted solution can only provide visual perception which is limited to a certain range and useful for individuals, and does not include all details of the regenerated vision, such as color, depth, texture, etc., so that the damage to the visual system is not negligible, and the operation has potential risks, besides affecting the beauty, there are many problems of great psychological stress of patients, high cost, etc.
Disclosure of Invention
The invention aims to solve the technical problem of providing a device which is low in risk and low in cost and can stimulate the visual perception of the blind person through the body surface of a human body by non-implantation aiming at the defects of high risk and high cost of the implantation electrode in the prior art.
The technical scheme adopted by the invention for solving the technical problems is as follows: constructing a non-implantable device for stimulating the visual perception of a blind person through the body surface of a human, comprising:
a main control module;
the input module is connected to the main control module and is used for receiving a setting signal which is input by a user and is related to the frequency and/or the amplitude of the current;
the stimulation current generation module is connected with the main control module and is used for generating at least one group of stimulation currents according to the setting signal under the control of the main control module, and the stimulation currents are superposition of low-frequency pulse currents and low-frequency pulse currents or superposition of the low-frequency pulse currents and intermediate-frequency pulse currents;
the output module is connected with the at least one stimulation current generation module and comprises a plurality of groups of non-implantable electrodes, the electrodes are in contact with the body surface, and the stimulation current is output from the electrodes and stimulates the blind person to generate the light sensation through the body surface.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, the stimulation current is the superposition of low-frequency pulse current with the frequency below 60Hz and other low-frequency pulse current; or,
the stimulation current is the superposition of low-frequency pulse current with the frequency below 60Hz and intermediate-frequency pulse current.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, a group of non-implantable electrodes comprises two electrodes which are respectively contacted with the body surface around the eye.
In the non-implantable device for stimulating the visual perception of the blind through the body surface of the human body, a group of non-implantable electrodes comprises an electrode in contact with an eyelid and an electrode in contact with the body surface of the hindbrain.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, the electrode is a cornea electrode so as to stimulate the blind person to generate light perception through the cornea.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, in the plurality of groups of non-implantable electrodes, each group of non-implantable electrodes outputs stimulation currents with different frequencies and/or different amplitudes.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, a group of non-implantable electrodes output stimulation currents with different frequencies and/or different amplitudes at intervals of a certain time.
In the non-implantable device for stimulating the visual perception of the blind through the body surface of the human body, the device further comprises a plurality of groups of colored lamp groups, and each group of colored lamp groups generates a monochromatic light for stimulating the visual perception of the blind through the monochromatic light.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, the device further comprises a strong light source which generates strong light for stimulating the blind person with strong light vision.
In the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body, the device further comprises a display module which is connected with the main control module and is used for displaying the setting information and the stimulation current information related to the frequency and/or the amplitude of the current.
By implementing the technical scheme of the invention, superimposed stimulation currents with different amplitudes and/or different frequencies are output by a micro-control technology and act on the body surface of a human body through the electrodes, so that the blind can generate light sensation, such as visual sensation of colored light and images.
Drawings
The invention will be further described with reference to the accompanying drawings and examples, in which:
FIG. 1 is a logic diagram of a first embodiment of the non-implantable device for stimulating the visual perception of a blind person through the body surface of a human body according to the present invention;
FIG. 2 is a schematic diagram of a first embodiment of the input module of FIG. 1;
FIG. 3 is a circuit diagram of a first embodiment of the master control module of FIG. 1;
FIG. 4 is a circuit diagram of a frequency generation subunit of the frequency generation unit of FIG. 1;
FIG. 5 is a circuit diagram of a portion of one embodiment of the amplitude generation unit of FIG. 1;
FIG. 6 is a circuit diagram of a portion of one embodiment of the amplitude generation unit of FIG. 1;
FIG. 7 is a circuit diagram of a first embodiment of a power amplification unit and an over-current protection module in the non-implantable device for stimulating blind visual perception through the body surface of a human body according to the present invention;
FIG. 8 is a circuit diagram of a first embodiment of a color lamp control module and a driving module in the non-implantable device for stimulating the visual perception of the blind via the body surface of a human body according to the invention.
Detailed Description
The objects, features and characteristics of the present invention, as well as the methods of operation and the functions of the related elements of structure and the combination of parts, will become more apparent upon reading the following description and the appended claims with reference to the accompanying drawings. It is to be expressly understood that the drawings are for the purpose of illustration and description only and are not intended as a definition of the limits of the invention.
Fig. 1 is a logic diagram of a first embodiment of the non-implantable device for stimulating blind visual perception through a body surface of a human body according to the present invention, the device includes a main control module 11, an input module 12, a stimulation current generation module 1, an output module 16 and a display module 17, wherein the stimulation current generation module 1 includes a frequency generation unit 13, an amplitude generation unit 14 and a power amplification unit 15. In addition, the input module 12, the frequency generation unit 13, the amplitude generation unit 14 and the display module 17 are respectively connected to the main control module 11, and the connections referred to herein may be electrical connections and/or mechanical connections. Further, the power amplifying unit 15 is connected to the amplitude generating unit 14 and the output module 16, respectively. It should be noted that only one stimulation current generation module 1 and one frequency generation unit 13, one amplitude generation unit 14 and one power amplification unit 15 corresponding to the stimulation current generation module 1 are shown in the figure, and it should be understood that when the number of stimulation current generation modules 1 is plural, that is, when plural sets of stimulation currents are generated, the number of frequency generation units is correspondingly plural, that is, when plural sets of stimulation currents are generated by respectively superimposing a low-frequency pulse current and a low-frequency pulse current or a low-frequency pulse current and a medium-frequency pulse current, the number of amplitude generation units and power amplification units is correspondingly increased. In the present invention, the low frequency pulse current refers to a pulse current with a frequency lower than 1000Hz, the intermediate frequency pulse current refers to a pulse current with a frequency between 1KHz and 100KHz, and both the low frequency pulse current and the intermediate frequency pulse current are small currents that do not harm human bodies. In this embodiment, the input module 12 is used for receiving a setting signal input by a user, and the setting signal may be a setting signal related to the frequency and/or amplitude of the current; the display module 17 is used for displaying setting information and stimulation current information related to the frequency and/or amplitude of the current; the frequency generating unit 13 is configured to generate a group of pulse signals with a medium-low frequency according to the setting signal under the control of the main control module 11; the amplitude generating unit 14 is configured to generate a stimulation current signal with a corresponding amplitude according to the setting signal and the pulse signal output by the corresponding frequency generating unit under the control of the main control module 11, and the power amplifying unit 15 is configured to perform power amplification on the stimulation current signal; the output module 16 includes a plurality of non-implanted electrodes that output stimulation current signals and excite the blind to produce photoreceptors through the body surface. In various embodiments of the present application, the body surface includes not only the body surface (i.e., skin) but also the cornea of the eyeball, that is, various suitable electrodes can be selected according to whether the electrodes are in contact with the body surface or the cornea, and the photoreceptors can be specifically color light and image visual perception, wherein a single set of electrodes has 2 outputs, which is composed of three parts, namely, a plug, a lead wire and an electrode head. Preferably, the plug is further provided with a conductive circular hole, so that the other group of electrode plugs can be inserted into the circular hole to realize expansion. The number of electrode heads can be 2, 4, 6, etc., so that the electrodes of the device have good flexibility and expandability in use. In addition, in order to facilitate the handheld operation, part of the electrode head is of a round strip-shaped structure. In an exemplary embodiment, the electrode tip is brought into contact with a body surface around the eye, thereby achieving optimal light perception excitation. Of course, can be with the electrode tip with the arbitrary position contact of body surface to all can realize arousing the light perception of vision, the difference of the electrode tip contact of different body surface positions lies in will obtaining different excitation effect and experience. It is further preferred that two electrode tips are used correspondingly, one of which is in contact with the eyelid and the other of which is in contact with the surface of the hindbrain, whereby the light sensation excitation is performed perpendicularly to the eyeball between the two electrode tips. It is still further preferred that the electrode is a corneal electrode, i.e. the electrode is in direct contact with the cornea, so that the light perception of the blind person can be excited more directly through the cornea. Here, the active electrode in direct contact with the cornea may be various types of contact lens electrodes and other kinds of suitable electrodes.
In addition, the stimulation current signal output by the power amplification unit is generated by superimposing pulse signals. In the plurality of sets of non-implantable electrodes, each set of non-implantable electrodes outputs a stimulation current of a different frequency and/or a different amplitude. Specifically, the low-frequency pulse current and the low-frequency pulse current or the low-frequency pulse current and the intermediate-frequency pulse current are superimposed to obtain the stimulation current signal, that is, one of the features of the present invention is that the superimposed pulse current signal is used as the stimulation current signal instead of the single low-frequency pulse current signal or the single intermediate-frequency pulse current signal, and a specific superimposing process is not described in detail herein, which may adopt a method suitable in the prior art, and the device is used as a medical device, the output voltage meets the specification requirement of medical electrical equipment, and as a preferred embodiment, the output voltage is below 36V. In an exemplary embodiment, the stimulation current signal is a superposition of the low frequency pulsed current with a frequency below 60Hz and a further low frequency pulsed current, which may be another low frequency pulsed current or currents, as will be appreciated. In another exemplary embodiment, the stimulation current is a superposition of a low frequency pulse current with a frequency below 60Hz and a medium frequency pulse current, and likewise, the further medium frequency pulse current may be another medium frequency pulse current or multiple medium frequency pulse currents. The number of pulse currents to be superimposed and the choice of using low or medium frequency pulse currents for the superimposition may be flexibly varied according to the individual specificity of the excited subject and the requirements required for stimulation. In addition, pulse currents in a specific frequency band (below 60 Hz) are selected to be superposed so as to realize optimal light perception excitation for the blind. In addition, in the exemplary embodiment, the frequency is dynamically changed and the amplitude is correspondingly adjusted according to the difference of the physiological resistance of a specific individual, so that diversified and personalized excitation of the specific blind person is realized, namely, optimal light perception excitation is realized for the specific blind person.
In addition, the user can set the stimulation current to be output intermittently through the input module, so that a group of non-implanted electrodes can output stimulation current with different frequencies and/or different amplitudes at certain time intervals.
Preferably, the non-implantable device for stimulating the visual perception of the blind person through the body surface of the human body further comprises an overcurrent protection module, and the overcurrent protection module carries out overcurrent protection on the stimulation current signal output by the power amplification unit.
The specific structure of a preferred embodiment of the non-implantable device for stimulating the visual perception of blind persons through the body surface of a human body is described as follows:
with reference to fig. 2, the input module uses a 4 × 4 keyboard, and the function of each key is as follows:
"1": increase photoelectric function intensity "2": weakening the strength of photoelectric function
"3": increase in frequency "a": reducing the frequency
"4": intermediate frequency plus "5": 3 group schemes add
"6": 3 group schemes minus "7": second channel strength plus
"8": strength reduction "9": 3 group protocol once in 3 seconds
"B": timing "C": 3 protocol once in 5 seconds
"D": pause function shift ": intelligent functional automation
Referring to fig. 3, the main control module is used as a core device of the whole circuit, all information is processed by the device, for example, a single chip microcomputer U1 with model number AT89S52 of ATMEL company can be adopted, and the single chip microcomputer U1 is a low-power-consumption and high-performance CMOS8 bit microcontroller with 8K in-system programmable Flash memory. Manufactured using Atmel corporation high density non-volatile memory technology, is fully compatible with industry 80C51 product instructions and pins. On-chip Flash allows program memory to be programmable in the system, and is also suitable for conventional programmers. On a single chip, a smart 8-bit CPU and a system programmable Flash are provided, so that the AT89S52 provides a highly flexible and super-effective solution for a plurality of embedded control application systems. The main properties are as follows: compatible with MCS-51 single chip microcomputer products; 8 Kbytes are in a system programmable Flash memory; 1000 erasing and writing cycles; all-static operation: 0Hz to 33 Hz; a third level encrypted program memory; 32 programmable I/O port lines; three 16-bit timers/counters; eight interrupt sources; a full duplex UART serial channel; low power idle and power down modes; the interruption can be awakened after power failure; a watchdog timer; a double data pointer; a power down identifier. In the single chip microcomputer U1, P1.0-P1.7 are external keyboard interfaces and can respectively control the frequency and output amplitude of the system; INT0(P32), INT1(P33), TXD (P31) and RXD (P30) are four pulse output ends, and the single chip microcomputer U1 can output the needed intermediate frequency base waveform and the waveform of the modulation wave frequency by means of keyboard control; pin 31 high indicates that internal program memory is used; the 18 and 19 pins are externally connected with a 12MHZ crystal oscillator to generate a clock with the period of 1US for the work of the singlechip U1, and the two capacitors C2 and C3 have a fine adjustment effect on the frequency of the crystal oscillator. In addition, the physician may select a particular series of procedures from a plurality of stored procedures within the physician's office based on the patient's condition.
The display module is a dot matrix graphic liquid crystal display, for example, a display (not shown) with model number TG12864 is used to display the related information. Referring to fig. 1, J1 is a resistor bank with a resistance of 10 kilo-ohms and provides a pull-up resistor for the P00-P07 ports of the single chip microcomputer. The display with model TG12864 is a dot-matrix graphic liquid crystal display with 4-bit/8-bit parallel, 2-line or 3-line serial interfaces and the internal part containing national standard first-level and second-level simplified Chinese character libraries, and has the display resolution of 128 x 64, and 8192 built-in 16 x 16 Chinese characters and 128 16 x 8 ASCII character sets. By using the flexible interface mode and simple and convenient operation instruction of the display, a full Chinese man-machine interactive graphical interface can be formed. The Chinese characters of 8 × 4 rows and 16 × 16 lattices can be displayed, and the graphic display can also be completed. In addition, low voltage and low power consumption are another significant feature thereof. The basic characteristics are as follows: low power supply voltage (VDD: +3.0- + 5.5V); the display resolution is 128 multiplied by 64 points; a Chinese character library is built in, 8192 lattice Chinese characters (the simplified and original forms can be selected) with 16 multiplied by 16 are provided; 128 built-in 16 x 8 lattice characters; 2MHZ clock frequency; the display mode is as follows: STN, semi-transparent, positive display; a driving mode: 1/32DUTY, 1/5 BIAS; viewing angle direction: 6, point; backlight mode: the side part of the LED is high-brightness white, and the power consumption is only 1/5-1/10 of that of a common LED; the communication mode is as follows: the serial port and the parallel port are selectable; a DC-DC conversion circuit is arranged in the device, and no additional negative voltage is needed; chip selection signals are not needed, and software design is simplified; the working temperature is 0 to 55 ℃; the storage temperature is-20 ℃ to +60 ℃.
The frequency generating unit includes two frequency generating subunits, each of which can generate an intermediate frequency or a low frequency signal. The circuit structure of one of the frequency generation subunits is described below with reference to fig. 4, in which a first end of a first resistor R8 is connected to a PULSE output terminal (PULSEI 1) of the single chip microcomputer U1, a second end of the first resistor R8 is connected to a base of a first transistor BG1, an emitter of the first transistor BG1 is grounded, a collector of the first transistor BG1 is connected to a voltage of 9V through a second resistor R9, and a collector of the first transistor BG1 is an output terminal (PULSE 1) of the frequency generation subunit. It should be understood that the circuit structure of the other frequency generation subunit is the same as that of the other frequency generation subunit, and the output terminal thereof is PULSE 2.
With reference to fig. 5 and 6, in the amplitude generating unit, the DA converter is a 4-channel 8-bit potential output DA converter U2 of model TLC5620, and the analog switch is an analog switch module of model CD4066, which includes 4 independent analog switches, only two of which are shown in the figure U5A and U5B. The Reference End (REFA) of the DA converter U2 is connected with the adjustable end of the rheostat W3, and the other two ends of the rheostat W3 are respectively connected with high voltage and ground for providing reference voltage for the DA converter, so that the purpose of controlling the amplitude is achieved. The digital quantity serial interface (DATA), the clock interface (CLK) and the serial loading control port (LOAD) of the DA converter U2 are respectively connected with corresponding output ends (P22, P21 and P20) of the singlechip, the output end of the DA converter U2 is connected with the non-inverting input end of the operational amplifier U4A, the inverting input end of the operational amplifier U4A is connected with the output end thereof, the output end of the operational amplifier U4A is further connected with the input end of a first analog switch U5A, the output end of the first analog switch U5A is connected with the input end of a second analog switch U5B, the control end of the first analog switch U5A and the control end of the second analog switch U5B are respectively connected with the output ends (PULSE 1 and PULSE 2) of the two frequency generation units, and the output end of the second analog switch U5B is the output end (OUT 1) of the amplitude generation unit. In addition, the resistor R3 is connected between the output terminal of the first analog switch U5A and ground, and the resistor R4 is between the output terminal of the second analog switch U5B and ground, and in other embodiments, the resistors R3 and R4 may be omitted.
Referring to fig. 7, in the power amplification unit, an inverting input terminal of a second operational amplifier U4C is grounded through a fourth resistor R10, a non-inverting input terminal of a second operational amplifier U4C is connected to an output terminal (OUT 1) of a second analog switch U5B through a fifth resistor R17, an output terminal of the second operational amplifier U4C is connected to the inverting input terminal thereof through a third resistor R18, a base of a second transistor BG5 is connected to an output terminal of the second operational amplifier U4C, a collector of the second transistor BG5 is connected to a 9V voltage, an emitter of the second transistor BG5 is the output terminal of the power amplification unit, and is connected to a plurality of groups of electrodes through an interface J31. In addition, in the overcurrent protection module, the cathode of the first diode D1 is connected with the collector of the second transistor BG5, the anode of the first diode D1 and the cathode of the second diode D2 are connected in parallel with the emitter of the first transistor BG5, and the anode of the second diode D2 is grounded.
In addition, the non-implantation device for stimulating the visual perception of the blind through the body surface of the human body further comprises: the color lamp control module is used for receiving a mode setting signal of the color lamp group; the driving module is used for controlling the color lamp groups to emit light according to the mode setting signal, and the color lamp groups generate monochromatic light for visually exciting the blind, namely further visually exciting the blind, wherein the monochromatic light can be red light, yellow light, blue light and the like and can be flexibly changed according to actual needs. It is understood that the monochromatic light can be obtained by blending the three primary colors of red, green and blue.
Assuming that the color lamp groups share four groups, with reference to fig. 8, in the driving module, the shift register is a shift register U3 with model number MC14015, the clock circuit is composed of a 555 timer U4 and peripheral components, and provides a clock signal for the shift register U3, and the rheostat W1 is used for controlling the time interval of turning on and off the color lamps. Bases of four driving triodes Q1, Q2, Q3 and Q4 are respectively connected with four output ends (Q1A, Q2A, Q3A and Q4A) of a shift register U3 through current limiting resistors R22, R23, R24 and R25, emitters of the four driving triodes Q1, Q2, Q3 and Q4 are grounded, collectors of the four driving triodes Q1, Q2, Q3 and Q4 are respectively connected with control electrodes of bidirectional thyristors Q6, Q7, Q8 and Q9 through current limiting resistors R26, R27, R28 and R29, and two ends of the bidirectional thyristors Q6, Q7, Q8 and Q9 are respectively connected with a positive electrode and a negative electrode of a corresponding color lamp group (not shown) through an interface J2.
With reference to fig. 8, the color lamp control module includes a band switch and a selection circuit for turning on the corresponding triac according to the setting of the band switch, wherein the band switch is connected to the selection circuit through an interface J3, the selection circuit includes diodes D3-D8, a triode Q5 and a resistor R11, wherein anodes of diodes D3, D4, D5 and D6 are respectively connected to four output terminals of a shift register U3, a cathode of a diode D3 and an anode of a diode D7 are connected to a first contact of the band switch through an interface J3, a cathode of a diode D4 and an anode of a diode D9 are connected to a second contact of the band switch through an interface J3, a cathode of a diode D9 and an anode of a diode D8 are connected to a third contact of the band switch through an interface J3, a cathode of a diode D6 is connected to a fourth contact of the band switch through an interface J3, and cathodes of diodes D7, D9 and D8 are connected to a fifth contact of the band switch 3 through an interface J8672, the base electrode of the triode Q5 is connected with the sixth contact of the wave band switch through a resistor R20 and an interface J3, the emitter electrode of the triode Q5 is grounded, the collector electrode of the triode Q5 is connected with high voltage through a resistor R21, and the collector electrode of the triode Q5 is also connected with the data input end of the shift register U3.
In an exemplary embodiment, the non-implantable device for stimulating the visual perception of a blind person through the body surface of a human body of the invention further comprises an intense light source which generates intense light for intense light stimulation of the blind person, that is, for making a still further visual stimulation of the blind person. In various embodiments of the present application, the intense light source refers to a light source (e.g., a white light source) having a color temperature of 6000K or more and a brightness of 32000LM (lumens), and the intense light source may be, for example, a xenon lamp or a halogen lamp, and further, a xenon lamp is preferably used.
It should be noted that, when the blind is excited by using a strong light source, unlike the prior art that uses flashing light and graphic stimulation, the embodiment of the present application uses a high color temperature and high brightness and a continuous stimulation mode instead of a flashing mode, so that better visual stimulation can be obtained.
In an exemplary embodiment, the working principle of the non-implanted device for stimulating the visual perception of the blind through the body surface of the human body is explained as follows: a user firstly sets frequency and amplitude through keys of an input module, after the setting information is transmitted to the single chip microcomputer U1, the single chip microcomputer U1 outputs corresponding pulse signals, and the corresponding frequency generation unit outputs intermediate-frequency or low-frequency signals according to the pulse signals and sends the intermediate-frequency or low-frequency signals to control ends of the first analog switch U5A and the second analog switch U5B. Meanwhile, the singlechip U1 controls the DA converter U2 to output analog signals with corresponding amplitudes, the analog signals are changed into stimulation current signals with certain frequency and certain amplitudes after passing through the first analog switches U5A and U5B, and the stimulation current signals are amplified by the operational amplifier U4C and the triode BG5 and then output to the electrodes through the interface J31. When the electrodes are placed on the body surface (not only on eyes and heads, but also on hands, feet, chest, back, abdomen, neck and other body parts), the stimulation current is conducted to the visual system to activate the visual cells which are not completely necrotic and restore and regenerate the visual function. Therefore, the mode of contacting the human body surface through the electrodes can generate the visual perception of colorful light and images, and tests prove that part of 5-level blind people can still activate the residual visual cells through the mode. Through stimulation, the blind can pass visual space tests such as gate finding, object positioning, 1-3 m identification index and the like from no light feeling; through further stimulation for many times for training, the vision is effectively improved, and the best person can improve the vision to more than 0.5, wherein the vision comprises all details of regenerated vision, such as color, depth and texture, and has the stereoscopic vision and fine vision capability. For the detection of people with eyesight, the electrodes are selected from a plurality of positions including four limbs and trunk parts of the body except eyes, a binocular closed state is adopted, visual information changes along with different body surface positions and parameters of the electrodes, the colors of the electrodes are white, blue, yellow, red, green and mixed colors, the shapes of the electrodes are various patterns such as dots, columns, nets and the like, the visual perception brightness is sufficient, and the electrodes can be perceived in the eye opening state.
In addition, the user can select different color lamp groups to work through the wave band switch, and the method specifically comprises the following steps: the operation and the cut-off of the triode Q5 are controlled through different combinations of the first contact to the fifth contact, the collector of the triode Q5 is connected to the data input end of the shift register U3, so that the output end of the shift register U3 outputs four driving signals, the four driving signals respectively control the operation of four bidirectional thyristors through driving the triode, and meanwhile, the color lamp set works according to different frequencies and brightness, such as flickering and jumping, by means of the diodes D3-D9 which are conducted in a single direction, and the vision is further excited to train the vision.
In addition, the strong light source can generate strong light to further stimulate the blind to further train the vision.
The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the scope of the claims of the present invention.
Claims (10)
1. A non-implantable device for stimulating the visual perception of a blind person through the body surface of a human being, comprising:
a main control module;
the input module is connected to the main control module and is used for receiving a setting signal which is input by a user and is related to the frequency and/or the amplitude of the current;
the stimulation current generation module is connected with the main control module and is used for generating at least one group of stimulation currents according to the setting signal under the control of the main control module, and the stimulation currents are superposition of low-frequency pulse currents and low-frequency pulse currents or superposition of the low-frequency pulse currents and intermediate-frequency pulse currents;
the output module is connected with the at least one stimulation current generation module and comprises a plurality of groups of non-implantable electrodes, the electrodes are in contact with the body surface, and the stimulation current is output from the electrodes and stimulates the blind person to generate the light sensation through the body surface.
2. The non-implantable device for stimulating visual perception of a blind person through a body surface according to claim 1, wherein the stimulating current is a superposition of a low frequency pulse current with a frequency below 60Hz and another low frequency pulse current; or,
the stimulation current is the superposition of low-frequency pulse current with the frequency below 60Hz and intermediate-frequency pulse current.
3. The non-implantable device for stimulating blind visual perception through a body surface of a person according to claim 1, wherein the set of non-implantable electrodes includes two electrodes each in contact with the body surface around the eye.
4. The non-implantable device for stimulating visual perception by a blind person through a body surface of a human being as recited in claim 1, wherein the set of non-implantable electrodes includes an electrode in contact with an eyelid and an electrode in contact with a surface of a hindbrain.
5. The non-implantable device for stimulating the visual perception of a blind person through a body surface of a human body according to claim 1, wherein the electrodes are cornea electrodes to stimulate the blind person through the cornea to produce a photoreceptor.
6. The non-implantable device for stimulating visual perception of the blind through a body surface of a person according to claim 1, wherein among the plurality of non-implantable electrode sets, each non-implantable electrode set outputs a stimulation current of a different frequency and/or a different magnitude.
7. The non-implantable device for stimulating visual perception of the blind through a body surface of a person according to claim 1, wherein a set of non-implantable electrodes output stimulation currents of different frequencies and/or different amplitudes at intervals of time.
8. The non-implantable device for stimulating the visual perception of a blind person through the body surface of a human being according to any one of claims 1-7, further comprising a plurality of colored light sets, each colored light set producing a monochromatic light for visual stimulation of the blind person with the monochromatic light.
9. The non-implantable device for stimulating visual perception by a blind person through a body surface according to any one of claims 1-7, further comprising an intense light source that generates intense light for intense light visual stimulation of the blind person.
10. The non-implantable device for stimulating the visual perception of a blind person through a body surface according to any one of claims 1 to 7, further comprising a display module connected to the main control module and configured to display setting information related to the frequency and/or amplitude of the current and stimulation current information.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352303A (en) * | 2014-10-30 | 2015-02-18 | 北京大学 | Equipment and method for forming artificial vision by electrical stimulation |
| CN106236377A (en) * | 2016-09-12 | 2016-12-21 | 北京大学 | SCNS is utilized to form the equipment of artificial vision |
| CN109069831A (en) * | 2016-03-16 | 2018-12-21 | 新星眼加拿大制造有限公司 | Microcurrent device and method for treating visual diseases |
| CN113398471A (en) * | 2021-07-28 | 2021-09-17 | 浙江京兆医疗器械有限公司 | Method and equipment for assisting in controlling eye diseases |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4664117A (en) * | 1984-10-09 | 1987-05-12 | Beck Stephen C | Apparatus and method for generating phosphenes |
| JPH08297465A (en) * | 1995-04-26 | 1996-11-12 | Hiroshi Yamamoto | Optic nerve video output device and its method |
| WO2004049986A1 (en) * | 2002-12-05 | 2004-06-17 | Nidek Co., Ltd. | Artificial visual system |
| US6889085B2 (en) * | 2000-10-17 | 2005-05-03 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
| US20080183243A1 (en) * | 2007-01-30 | 2008-07-31 | Nidek Co., Ltd | Vision regeneration assisting apparatus |
| CN101390789A (en) * | 2008-09-25 | 2009-03-25 | 上海交通大学 | Tactile-Visual Substitution System Based on Electrical Stimulation |
| CN102813999A (en) * | 2012-08-10 | 2012-12-12 | 上海交通大学 | Visual prosthesis wireless transmission system with self-adaptive power regulation function and visual prosthesis wireless transmission method |
| US20130211475A1 (en) * | 2012-02-10 | 2013-08-15 | Nokia Corporation | Methods And Apparatus For Representing User Output Data By Transcutaneous Stimulation Of A User's Optic Nerve |
| CN103479474A (en) * | 2013-10-10 | 2014-01-01 | 国家电网公司 | Device for sensing surrounding environment |
-
2014
- 2014-02-20 CN CN201410058933.6A patent/CN103816006B/en active Active
Patent Citations (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4664117A (en) * | 1984-10-09 | 1987-05-12 | Beck Stephen C | Apparatus and method for generating phosphenes |
| JPH08297465A (en) * | 1995-04-26 | 1996-11-12 | Hiroshi Yamamoto | Optic nerve video output device and its method |
| US6889085B2 (en) * | 2000-10-17 | 2005-05-03 | Sony Corporation | Method and system for forming an acoustic signal from neural timing difference data |
| WO2004049986A1 (en) * | 2002-12-05 | 2004-06-17 | Nidek Co., Ltd. | Artificial visual system |
| US20060058857A1 (en) * | 2002-12-05 | 2006-03-16 | Yasuo Tano | Artificail vision system |
| US20080183243A1 (en) * | 2007-01-30 | 2008-07-31 | Nidek Co., Ltd | Vision regeneration assisting apparatus |
| CN101390789A (en) * | 2008-09-25 | 2009-03-25 | 上海交通大学 | Tactile-Visual Substitution System Based on Electrical Stimulation |
| US20130211475A1 (en) * | 2012-02-10 | 2013-08-15 | Nokia Corporation | Methods And Apparatus For Representing User Output Data By Transcutaneous Stimulation Of A User's Optic Nerve |
| CN102813999A (en) * | 2012-08-10 | 2012-12-12 | 上海交通大学 | Visual prosthesis wireless transmission system with self-adaptive power regulation function and visual prosthesis wireless transmission method |
| CN103479474A (en) * | 2013-10-10 | 2014-01-01 | 国家电网公司 | Device for sensing surrounding environment |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104352303A (en) * | 2014-10-30 | 2015-02-18 | 北京大学 | Equipment and method for forming artificial vision by electrical stimulation |
| CN109069831A (en) * | 2016-03-16 | 2018-12-21 | 新星眼加拿大制造有限公司 | Microcurrent device and method for treating visual diseases |
| CN106236377A (en) * | 2016-09-12 | 2016-12-21 | 北京大学 | SCNS is utilized to form the equipment of artificial vision |
| CN113398471A (en) * | 2021-07-28 | 2021-09-17 | 浙江京兆医疗器械有限公司 | Method and equipment for assisting in controlling eye diseases |
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|---|---|
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