CN103814937A - Insecticide composition - Google Patents

Abstract

The invention discloses a pesticide composition. The composition comprises an active ingredient A and an active ingredient B, wherein the active ingredient A adopts afidopyropen; the active ingredient B is selected from one of paichongding, cycloxaprid and cycolxylidin; the weight ratio of the active ingredient A to the active ingredient B is (1:80) to (80:1). The pesticide composition is used for controlling and preventing various injurious insects, such as plant hoppers and thrips, has an excellent synergistic interaction effect, and can improve the controlling and preventing effect, and reduce the usage amount of pesticide and the use cost of farmers.

Description

an insecticidal composition

technical field

The invention belongs to the field of agricultural insecticides, in particular to a class of insecticidal compositions containing afidopyropen and applications thereof.

Background technique

Afidopyropen (test code ME5343) is a new type of insecticide jointly researched and developed by Japan's Meiji Pharmaceutical Co., Ltd. and Japan's Kitasato Research Institute. This product is a brand-new structure and has a new mechanism of action. It can be used for vegetables, fruit trees, vines, row crops and ornamental plants to prevent and control sucking mouthparts pests such as aphids, planthoppers, scale insects and leafhoppers, etc. .

Pichamid is a new type of high-efficiency, broad-spectrum, and low-toxicity neonicotinoid insecticide with a unique mode of action. It acts on the axonal synaptic receptors of insect nerve conduction, blocks nerve conduction, and exhibits a strong feeding inhibition effect. It has a strong systemic conduction effect, can be quickly absorbed by crops, and has a good control effect on rice planthoppers and tea leafhoppers.

Cycloxapyrid is a new type of neonicotinoid insecticide, created by East China University of Science and Technology. The compound has systemic, stomach poisoning and contact killing effects, and can be used to prevent and control Homoptera and Coleoptera pests on crops. It has no cross-resistance with imidacloprid, acetamiprid, epoxycloprid, etc., and is also effective against Lepidoptera pests . The dosage of this product is low, it is safe to the environment, and has little or no harm to beneficial organisms. It has high insecticidal activity against aphids, whiteflies, planthoppers, flea beetles, cotton bollworms, diamondback moths, Spodoptera litura, armyworms, etc. of crops such as wheat, cotton, rice, fruit trees, and vegetables.

Cycloxylidin belongs to neonicotinoid insecticides and was created by Wuhan Engineering University. The compound has systemic, stomach poisoning and contact killing effects, and its structure is close to that of imidacloprid, but its activity is higher than that of imidacloprid, and it has higher activity against sucking mouthparts pests such as aphids and whiteflies.

At present, there is no report about the technical scheme of combining afidopyropen with picloprid or cyclocloprid or cyclocloprid.

Contents of the invention

The object of the present invention is to provide an insecticidal composition with remarkable synergistic effect, good control effect and low medication cost and its application.

For achieving the purpose of the invention, the technical scheme adopted in the present invention is:

A kind of insecticidal composition containing afidopyropen, the active ingredient of the composition is composed of two kinds of A and B, the active ingredient A is afidopyropen, and the active ingredient B is selected from the group consisting of Piclopyr, Cyclocloprid and Cyclocloprid Any one; the mass ratio of active ingredient A to active ingredient B is 80:1 to 1:80, preferably 40:1 to 1:40.

The insecticidal composition of the present invention can also be used in combination with other compounds with herbicidal and bactericidal properties, and can also be used in combination with nematicides, protective agents, growth regulators, plant nutrients or soil regulators.

Compared with the prior art, the insecticidal composition of the present invention can at least produce the following beneficial effects:

1. The two active components in the composition have obvious synergistic effect on pests after compounding according to the above ratio, and the insecticidal effect of the mixed composition is significantly improved compared with its single agent, which has a good effect of preventing insects and protecting seedlings;

2. The mechanism of action of the two active ingredients in the insecticidal composition is different, and the application of the composition can delay or overcome the resistance of pests;

3. The insecticidal composition with synergistic effect can reduce the amount of pesticide used in the field, effectively reduce environmental pollution and pesticide residues, and reduce the harm to beneficial organisms;

4. The composition has the characteristics of good quick effect and long lasting effect.

Detailed ways

In order to make the object, technical solution and technical advantages of the present invention clearer, the content of the present invention will be further described below in conjunction with the examples, but the present invention is by no means limited to these examples. The specific examples are only used to explain the present invention, not to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention shall be included within the protection scope of the present invention. Therefore, the protection scope of the patent for the present invention should be based on the appended claims.

An embodiment of the present invention provides an insecticidal composition containing afidopyropen, the composition is composed of active ingredient A and active ingredient B, the active ingredient A is afidopyropen, and the active ingredient B is selected from the group consisting of piperidin, cyclopyrid, epoxy Any one of cloprid; the mass ratio of active ingredient A to active ingredient B is 80:1-1:80, preferably 40:1-1:40.

The inventor screened through a large number of bioassay tests, unexpectedly found that afidopyropen and piclopyr or cyclocloprid or cyclocloprid compounded in the above ratio, can suck and suck planthoppers, aphids, whiteflies, thrips, etc. Pests with mouthparts have a significant synergistic effect. On the basis of the above findings, the present invention has been formed through the quantitative analysis of the combined effect of the composition, that is, afidopyropen is used as an active ingredient, and piperidopyropen or cyclocloprid is another effective ingredient. The ingredients, the two ingredients complement each other, act synergistically, and play an excellent synergistic effect.

The insecticidal composition of the embodiment of the present invention can be processed together with active ingredients, adjuvants and carriers (fillers) according to various factors such as crops to be controlled, environmental conditions, control methods, and control costs. Any acceptable dosage form, the preferred dosage form is granules, microcapsule suspensions, microemulsions, suspensions, emulsions in water, wettable powders, water dispersible granules or ultra-low volume liquids. The auxiliaries, carriers and processing techniques used are known components. In the above-mentioned various dosage forms, the total mass percentage content of afidopyropen and piclopyr or epidacloprid or cyclocloprid is 0.5% to 85%. When 20% and 4%, the total content is 24%; when the mass percentage content of afidopyropen and cyclopyrid is respectively 10% and 5%, the total content is 15%, and the value of concrete total mass percentage content is as follows example shown.

In order to make the object, technical solution and advantages of the present invention clearer, the present invention is further described with the following specific experimental examples. Unless otherwise specified, the ratios (including percentages) mentioned below are all mass ratios.

One, preparation processing recipe embodiment

Example 1: 40% afidopyropen·pichridam suspension concentrate (afidopyropen:pichrid=1:1)

Made according to the conventional process, wherein afidopyropen20g, pichram 20g, sodium lignosulfonate (dispersant) 4g, ethylene glycol (antifreeze) 4g, bentonite (thickener) 3g, organosilicone (defoamer) ) 3g, supplemented with deionized water to 100g.

In the present embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of both can be changed between 5～60%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Example 2: 60% afidopyropen·pichridam water dispersible granules (afidopyropen:pichrid=1:5)

Made according to the conventional process, afidopyropen 10g, pyridoxazole 50g, sodium alkylnaphthalene sulfonate (dispersant) 5g, sodium lignosulfonate (dispersant) 7g, sodium lauryl sulfate (wetting agent) 2g, sulfuric acid Ammonium (disintegrant) 5g, light calcium carbonate (filler) supplemented to 100g.

In this embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of the two can be changed between 5～80%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Example 3: 55% afidopyropen·pichram wettable powder (afidopyropen:pichrid=10:1)

Afidopyropen50g, pichamprid 5g, sodium lauryl sulfate (wetting agent) 2g, sodium lignosulfonate (dispersant) 3g, NNO (dispersant) 5g, kaolin supplemented to 100g.

In the present embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of both can be changed between 5～85%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Example 4: 12% afidopyropen·pichridam microemulsion (afidopyropen:pichridam=1:5)

Made according to the conventional process, afidopyropen2g, 10g of pyracrid, 10g of N-methylpyrrolidone (cosolvent), 8g of calcium dodecylbenzenesulfonate (emulsifier), styrylphenol polyoxyethylene ether (emulsifier) 7g, 5g of triphenylethylphenol polyoxyethylene (emulsifier), and deionized water (carrier) to make up to 100g.

In the present embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of both can be changed between 5～60%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Embodiment 5: 10% afidopyropen · cyclopyrid microcapsule suspension (afidopyropen: cyclopyrid=1:1)

afidopyropen5g, cyclopyridone 5g, cyclohexanone (solvent) 1g, polyisocyanate (curing agent) 0.4g, ethylene glycol (solvent) 0.4g, gum arabic (thickener) 1g, deionized water (carrier) to supplement to 100g.

In the present embodiment, the weight ratio of afidopyropen and cyclopyrid can be changed between 40:1～1:40, and the percentage by weight of the two can be changed between 5～60%. Make corresponding adjustments thereupon, form new embodiment.

Cyclocloprid can also be replaced by piclocloprid and cyclocloprid to form a new embodiment.

Embodiment 6: 15% afidopyropen · cyclopyrid aqueous emulsion (afidopyropen: cyclopyrid=1:2)

afidopyropen5g, cyclopyridine 10g, calcium dodecylbenzenesulfonate (emulsifier) 2.1g, phenethylphenol polyoxyethylene ether (emulsifier) 1.5g, cyclohexanone (solvent) 10.1g, toluene (solvent ) 10.2g, xanthan gum (thickener) 0.5g, deionized water (carrier) to make up to 100g.

In the present embodiment, the weight ratio of afidopyropen and cyclopyrid can be changed between 40:1～1:40, and the percentage by weight of the two can be changed between 5～60%. Make corresponding adjustments thereupon, form new embodiment.

Cyclocloprid can also be replaced by piclocloprid and cyclocloprid to form a new embodiment.

Example 7: 8.2% afidopyropen·pichridam granules (afidopyropen:pichridam=40:1)

afidopyropen 8g, pichamid 0.2g, dioctyl sodium sulfosuccinate 1g, wood plastic sodium sulfonate 2g, vinyl alcohol-vinyl alkyl ether copolymer 2.5g, and clay to make up to 100g.

In this embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of the two can be changed between 0.5～85%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Example 8: 12% afidopyropen·pichridam ultra-low volume liquid (afidopyropen:pichrid=1:5)

Afidopyropen2g, 10g of piperacrim, 10g of N-methylpyrrolidone, 15g of N,N-dimethylformamide, 2g of n-octanol, 2g of calcium dodecylsulfonate, 3g of octylphenol polyoxyethylene ether, C10 aromatics Make up to 100g.

In the present embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of both can be changed between 5～60%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

Example 9: 4.1% afidopyropen·pichridam granules (afidopyropen:pichridam = 1:40)

Afidopyropen 0.1g, Pichamid 4g, dioctyl sodium sulfosuccinate 1g, wood plastic sodium sulfonate 2g, vinyl alcohol-vinyl alkyl ether copolymer 2.5g, and clay to make up to 100g.

In this embodiment, the weight ratio of afidopyropen and pichamid can be changed between 40:1～1:40, and the weight percentage of the two can be changed between 0.5～85%. Make corresponding adjustments, form new embodiment.

Piclocloprid can also be replaced by cyclocloprid and cyclocloprid to form a new embodiment.

2. Biological Activity Determination and Drug Efficacy Test Example

Combining the active ingredients of different pesticides to make pesticides is an effective and fast way to develop and develop new pesticides and prevent and control resistant pests in agriculture. When pesticides of different varieties are mixed, they usually show three types of effects: additive effect, synergistic effect and antagonistic effect. However, the specific role cannot be predicted, and can only be determined through a large number of experiments.

Through a large number of screening tests, the inventors found that the combination of afidopyropen and piclopyr or cyclopyrid or cyclocloprid has obvious synergistic effect on piercing-sucking mouthparts pests such as planthoppers and thrips. Therefore, the present invention The embodiment of the invention also provides the application of the above insecticidal composition in the control of rice brown planthopper, western flower thrips and other piercing-sucking mouthparts pests. The control effect is not just the simple addition of the two agents, as illustrated by the following biological assay examples.

1) Bioassay example: combined toxicity determination of afidopyropen with piclopyr or cyclopyrid or cyclocloprid against rice brown planthopper

Test object: Rice brown planthopper (Nilaparvata lugens (Stdl)), a sensitive species provided by the Department of Pesticides, School of Resources and Environment, South China Agricultural University, was grown indoors with potted rice, and the same 3rd instar nymphs were picked for the test.

Test method: refer to the Indoor Bioassay Test Guidelines for Pesticides Insecticide NY/T1154.11-2008, and adopt the rice stem dipping method.

The co-toxicity coefficient (CTC) method was used to determine the joint action mode. The formula for calculating the co-toxicity coefficient is as follows:

Actual toxicity index (ATI) = (standard drug LC ₅₀ / test drug LC ₅₀ ) × 100

Theoretical toxicity index (TTI) = A drug ATI × the percentage of A in the mixture + B drug ATI × the percentage of B in the mixture

Co-toxicity coefficient (CTC) = [mixture measured toxicity index (ATI) / mixture theoretical toxicity index (TTI)] × 100

When CTC≤80, the composition exhibits antagonistic effect; when 80<CTC<120, the composition exhibits additive effect; when CTC≥120, the composition exhibits synergistic effect.

Test results: afidopyropen and piclocloprid, afidopyropen and cyclopyrid, and afidopyropen and cyclocloprid, respectively compounded, the combined toxicity test results against rice brown planthopper are shown in Table 1-3.

Table 1 Combined toxicity test of afidopyropen and pichridam in different ratios to rice brown planthopper

deal with _LC50 (μg/mL) ATI TTI Co-toxicity coefficient CTC afidopyropen 0.24 100.00 Piperidin 0.87 27.59 afidopyropen80: Piperpyropen 1 0.19 126.32 99.11 127.46 afidopyropen40: phenidopyropen1 0.11 218.18 98.23 222.10 afidopyropen20: phenidopyropen1 0.13 184.62 96.55 191.21 afidopyropen10: piperopenia 1 0.10 240.00 93.42 256.91 afidopyropen5: piperopenia 1 0.12 200.00 87.93 227.45 afidopyropen1: piperopenia 1 0.20 120.00 63.79 188.11 afidopyropen1: piperopenia 5 0.28 85.71 39.66 216.15 afidopyropen1: piperopenia 10 0.34 70.59 34.17 206.58 afidopyropen1: piperopenia 20 0.39 61.54 31.03 198.29

afidopyropen1: piperopenia 40 0.43 55.81 29.35 190.15 afidopyropen1: piperopenia 80 0.68 35.29 28.48 123.93

The results of the combined toxicity test in Table 1 show that the co-toxicity coefficient CTC of the combination of afidopyropene and pichridam in the ratio of 80:1 to 1:80 is greater than 120 in the joint toxicity test of rice brown planthopper, which has a synergistic effect . Especially in the ratio range of 40:1-1:40, the CTC is greater than 180, and the synergistic effect is remarkable.

Table 2 Combined toxicity test of afidopyropen and cyclopyrid in different ratios to rice brown planthopper

deal with _LC50 (μg/mL) ATI TTI Co-toxicity coefficient CTC afidopyropen 0.27 100.00 Cyclopyrid 1.23 21.95 afidopyropen80: afidopyropen1 0.20 135.00 99.04 136.31 afidopyropen40: cyclopyropenia 1 0.14 192.86 98.10 196.60 afidopyropen20: afidopyropen1 0.15 180.00 96.28 186.95 afidopyropen10: afidopyropen1 0.13 207.69 92.90 223.55 afidopyropen5: afidopyropen1 0.16 168.75 86.99 193.98 afidopyropen1: afidopyropen1 0.22 122.73 60.98 201.27 afidopyropen1: cyclopyropenia 5 0.41 65.85 34.96 188.37 afidopyropen1: afidopyropen10 0.49 55.10 29.05 189.70 afidopyropen1: cyclopyropenia 20 0.53 50.94 25.67 198.47 afidopyropen1: cyclopyropenia 40 0.47 57.45 23.85 240.82 afidopyropen1: cyclopyropenia 80 0.91 29.67 22.91 129.48

The results of the combined toxicity test in Table 2 show that the co-toxicity coefficient CTC of the combination of afidopyropen and cyclopyrid in the ratio of 80:1 to 1:80 is greater than 120 in the joint toxicity test of rice brown planthopper, which has synergistic effect effect. Especially in the ratio range of 40:1-1:40, the CTC is greater than 180, and the synergistic effect is remarkable.

Table 3 Combined toxicity test of afidopyropen and epoxycloprid in different ratios to rice brown planthopper

deal with _LC50 (μg/mL) ATI TTI Co-toxicity coefficient CTC afidopyropen 0.21 100.00 Cyclocloprid 2.69 7.81 afi dopyropen80: epoxycloprid 1 0.15 140.00 98.86 141.61 afidopyropen40: epoxycloprid 1 0.11 190.91 97.75 195.30 afidopyropen20: epoxycloprid 1 0.12 175.00 95.61 183.04 afidopyropen10: epoxycloprid 1 0.08 262.50 91.62 286.51 afidopyropen5: epoxycloprid 1 0.13 161.54 84.63 190.87 afidopyropen1: epoxycloprid 1 0.17 123.53 53.90 229.17 afidopyropen1: epoxycloprid 5 0.42 50.00 23.17 215.78 afidopyropen1: epoxycloprid 10 0.65 32.31 16.19 199.58 afi dopyropen1: epoxycloprid 20 0.91 23.08 12.20 189.20 afidopyropen1: epoxycloprid 40 1.05 20.00 10.06 198.90 afidopyropen1: epoxycloprid 80 1.69 12.43 8.94 138.92

The results of the combined toxicity test in Table 3 show that the co-toxicity coefficient CTC of the combination of afidopyropen and epoxycloprid in the ratio range of 80:1 to 1:80 is greater than 120 in the joint toxicity test of rice brown planthopper, which has synergistic effect effect. Especially in the ratio range of 40:1-1:40, the CTC is greater than 180, and the synergistic effect is remarkable.

2) Field drug efficacy test example

1. Control effect on rice brown planthopper

The test was carried out in a rice field in Wugang City, Hunan Province in August 2013. The test used a knapsack sprayer to spray the whole field evenly. The rice in the selected paddy field grew basically the same, and it was in the tillering stage. The occurrence of planthoppers was basically the same. Investigate the base number of insect population before the drug treatment, and check the number of living insects 1d, 7d, and 15d after the drug treatment. From the data in Table 4, it can be concluded that the synergistic effect of various formulations after compounding afidopyropen with picloprid or cyclocloprid or cyclocloprid is obvious; The control effect is also significantly better than a single agent.

Table 4 Field Control Effects of Controlling Rice Brown Planthopper

potion Dosage (g or 1d anti-efficacy% 7d Anti-efficacy% 15d anti-efficacy%

mL/667m ² ) 10% afidopyropen suspension concentrate 15mL 75.89 87.53 70.24 25% cyclopyrid wettable powder 15g 73.87 80.21 61.52 10% epoxycloprid wettable powder 30g 70.57 79.54 67.94 10% Picloprid Suspending Concentrate 30g 69.38 78.39 60.35 Example 1 15mL 70.94 91.28 80.47 Example 2 10g 75.69 99.87 87.54 Example 3 10g 71.28 97.64 81.56 Example 4 15mL 68.34 90.17 78.69 Example 5 15mL 65.79 90.48 82.47 Example 6 15mL 76.98 98.65 79.24 Example 7 15g 72.15 95.36 74.58 Example 8 60mL 73.56 96.87 80.51 Example 9 15g 67.58 90.45 70.26 CK clear water / / /

2. Control effect on western flower thrips of pepper

The test was carried out in Li Nong Vegetable Farm, Huidong County, Guangdong Province in April 2013. The test used a knapsack sprayer to spray the whole field evenly. The peppers selected for the test were in the peak period of flowering and fruiting, and the plant growth was basically the same. The incidence of horses is relatively heavy, and the distribution is basically the same. The population base of the insects is investigated before the medicine, and the number of live insects is checked 1d, 3d, and 7d after the medicine. From the data in Table 5, it can be concluded that the synergistic effect of various formulations after compounding afidopyropen with piclopyr or cyclocloprid or cyclocloprid is obvious; The control effect of flower thrips is also obviously better than single agent.

Table 5 Field Control Effects of Capsicum Western Flower Thrips

Judging from the field control effects of afidopyropen, picloprid or cyclocloprid or cyclocloprid on rice brown planthopper and capsicum western flower thrips, the control effect of each compound agent is significantly better than that of a single agent, indicating that the compound has synergistic effect Function; the prolonged effective period can reduce the dosage and frequency of application, delay the occurrence of pest resistance, and reduce the cost of control at the same time.

The above are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements and improvements made within the spirit and principles of the present invention should be included in the protection scope of the present invention. Inside.

Claims (7)

1. An insecticidal composition, characterized in that: the active ingredient of the composition is made up of two kinds of A and B, the active ingredient A is afidopyropen, and the active ingredient B is selected from the group consisting of piperid, epoxycloprid, epoxyclofen Any one of pyridine; wherein the mass ratio of active ingredient A to active ingredient B is 80:1-1:80. 2. The insecticidal composition according to claim 1, characterized in that the mass ratio of the active ingredient A to the active ingredient B is 40:1˜1:40. 3. The insecticidal composition according to claim 1 or 2, characterized in that the active ingredients and auxiliary ingredients of the composition are formulated into formulations suitable for agricultural use. 4. insecticidal composition according to claim 3, is characterized in that, described preparation suitable for agricultural use is granule, microcapsule suspension, microemulsion, water emulsion, suspending agent, wettable powder, water dispersion Granules, ultra-low volume liquids. 5. The insecticidal composition according to claim 4, characterized in that the total mass percentage of active ingredient A and active ingredient B in each formulation is 0.5%-85%. 6. The application of the pesticidal composition according to claims 1 to 5 for controlling the piercing-sucking mouthparts pests of rice, fruit trees and vegetable crops. 7. The application of the insecticidal composition according to claim 6, characterized in that, the piercing-sucking mouthparts pests are planthoppers and thrips.