CN103239763A - Sutureless ureterostenosis restoration operation material and system thereof - Google Patents
Sutureless ureterostenosis restoration operation material and system thereof Download PDFInfo
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- CN103239763A CN103239763A CN2012100234429A CN201210023442A CN103239763A CN 103239763 A CN103239763 A CN 103239763A CN 2012100234429 A CN2012100234429 A CN 2012100234429A CN 201210023442 A CN201210023442 A CN 201210023442A CN 103239763 A CN103239763 A CN 103239763A
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- ureter
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Landscapes
- Materials For Medical Uses (AREA)
Abstract
The invention provides a sutureless ureterostenosis restoration operation material, a preparation method of the material, a sutureless ureterostenosis restoration operation system including the material, and applications of rose bengal in the material and the system. Rose Bengal is supported on a rose bengal support, and a sutureless ureterostenosis restoration operation is completed through the local irradiation of a laser emission device. Results of clinic tests show that ureteral restenoses erupting after a traditional suture operation are not found, and there are also no tissue thermal damage phenomena.
Description
Technical field
The present invention relates to a kind of material for the operation of reparation stricture of ureter, relate in particular to a kind of material, system that exempts to sew up and effectively avoided the reparation stricture of ureter operation of ureter restenosis.
Background technology
Stricture of ureter refers to that the ureter bore is narrow and small, influences urine drains, and stricture of ureter is one of clinical more unmanageable problem, narrowly causes urinary tract obstruction, hydronephrosis, and then causes renal failure, has a strong impact on patient health and life.Generally stricture of ureter is divided into two classes: 1, congenital stricture of ureter; 2, Secondary cases stricture of ureter, the common cause of disease are due to the long-term pathological changes such as the narrow and ureteral calculus of congenital renal pelvis ureters intersection, inflammation or operation causes narrow.
The Therapeutic Method of present stricture of ureter is mainly the method for surgical incision plasty or non-operation placing rack in air bag expansion is put.
Traditional surgical operation cuts plasty and use the identical broken ends of fractured bone of suture needle suture after excising narrow section, its Therapeutic Method as routine is repaired for a long time and after being widely used in stricture of ureter, yet, there are a plurality of weak points in this method, at first sewing no all roses, because suture (pin) is as a kind of foreign body, can cause some patient immunoreation in various degree, also be the inducement that causes some post-operative infection simultaneously, in case concurrent local infection just needs extra anti-infective therapy, the existence of suture easily causes the healing back to generate because of cicatrix, thereby causes ureter secondary (again) narrow.In addition, this identical method need be by microsurgery instruments and microsurgical technique, and the uneven prognosis that has also greatly influenced the patient of the suturing skill of surgical doctor.
Various supports are placed in non-operation in the part after air bag placing rack method is to use the air bag expansion narrow section, carry out the method for interventional therapy as disclosed use internal metal rack in " the internal metal rack treatment of stricture of ureter " (China uses medical magazine, 2005 the 5th the 10th phases of volume) literary composition such as Jianzhong Wang; Song Guang comes disclosed use Ultimum Ti in " application of shape shape-memory titanium-nickel alloy net shape support in stricture of ureter " (Chinese magazine of urology surgery, the 22nd phase of calendar year 2001, the 440th page) literary composition such as grade to carry out the method for interventional therapy.Though the interventional therapy short run effect is good, can cause many complication after keeping somewhere ureter bracket, common have infection, capsid formation, hematuria and a sense of discomfort etc.Metal urethra or ureter bracket relevant issues comprise that also price is more expensive, insert the difficult taking-up in back, support displacement, the inwardly growth of fiber granulation tissue, epithelial proliferation, narrow, the serious fibrosis of ureter distal and secondary obstruction etc.
Summary of the invention
Repair too much, the excessive problem of restenosis incidence rate of the side effect that exists in the stricture of ureter operation at tradition, the invention provides a kind of exempt from sew up to repair the stricture of ureter surgical material, and preparation method thereof and system, and rose-redly exempt to sew up the application of repairing in the stricture of ureter surgical material described.
For this reason, first aspect of the present invention provides a kind of exempting from and sews up the material of repairing the stricture of ureter operation, comprising rose-red and rose-red carrier (the rose-red material that carries).
Wherein, described rose-red carrier is preferably solid carrier, as thin film, and biomembrane especially.
Wherein, described rose-red carrier material can be any one or a few the mixture in the composite formed of synthesized polymer material, natural macromolecular material and synthesized polymer material and natural macromolecular material.
The mixture of any one or a few in described natural macromolecular material such as amniotic membrane, collagen, cellulose, chitin, chitosan, glycosaminoglycans and the alginate.
The mixture of any one or a few in described natural polymer material such as polyurethane, polyglycolic acid, polylactic acid (especially Poly-L-lactic acid), polycaprolactone, the polyester or the copolymer of above-mentioned polymer monomer.The mixture of described natural polymer or copolymer such as glycolic-lactic acid copolymer, poly-ethanol/polylactic acid blend, polyethylene terephthalate/polybutylene terephthalate blend, ethylene glycol terephthalate-polybutylene terephthalate copolymer.
Blend such as polycaprolactone/collagen/lactic acid-ethanol copolymer/glucosan blend that described synthesized polymer material and natural macromolecular material are formed.
Second aspect of the present invention provides a kind of above-mentioned method of exempting to sew up reparation stricture of ureter surgical material for preparing, and is specially, and with rose-red carrier loaded in rose-red solution, drying prepares the described reparation stricture of ureter surgical material of exempting to sew up then.
Wherein, described rose-red carrier is preferably solid carrier, as thin film, and biomembrane especially.
Wherein, described rose-red carrier material can be any one or a few the mixture in the composite formed of synthesized polymer material, natural macromolecular material and synthesized polymer material and natural macromolecular material.
The mixture of any one or a few in described natural macromolecular material such as amniotic membrane, collagen, cellulose, chitin, chitosan, glycosaminoglycans and the alginate.
The mixture of any one or a few in described natural polymer material such as polyurethane, polyglycolic acid, polylactic acid (especially Poly-L-lactic acid), polycaprolactone, the polyester or the copolymer of above-mentioned polymer monomer.The mixture of described natural polymer or copolymer such as glycolic-lactic acid copolymer, poly-ethanol/polylactic acid blend, polyethylene terephthalate/polybutylene terephthalate blend, ethylene glycol terephthalate-polybutylene terephthalate copolymer.
Blend such as polycaprolactone/collagen/lactic acid-ethanol copolymer/glucosan blend that described synthesized polymer material and natural macromolecular material are formed.
In the above-mentioned a kind of preferred embodiment of exempting to sew up the method for repairing the stricture of ureter surgical material of preparation of the present invention, described load can be arbitrary load method well known by persons skilled in the art, as blend, but the present invention is more preferably with in rose-red carrier material dipping and the rose-red solution, dip time is preferably 1min above (comprising 1min), more elect 1.5min above (comprising 1.5min) as, more preferably more than the 2.5min (comprising 2.5min), more preferably more than the 3min (comprising 3min).
According to the above-mentioned a kind of preferred embodiment of exempting to sew up the method for repairing the stricture of ureter surgical material of preparation of the present invention, described rose-red solution weight concentration is 0.05%～0.2%, be preferably 0.05%～0.15%, as 0.05%, 0.07%, 0.08%, 0.09%, 0.1%, 0.11%, 0.12%, 0.15% etc.
The 3rd aspect of the present invention provides a kind of rose-red exempting to sew up the application of repairing in the stricture of ureter surgical material, especially exempts to sew up the application of repairing in the stricture of ureter surgical material in preparation.
The 4th aspect of the present invention provides a kind of above-mentioned described system of stitching reparation stricture of ureter that exempts from of repairing the stricture of ureter surgical material that exempts to sew up that comprises, comprise and exempt to sew up the rose-red and rose-red carrier of repairing in the stricture of ureter surgical material, also comprise the 532nm laser transmitting set.
Wherein, described rose-red carrier is preferably solid carrier, as thin film, and biomembrane especially.
Wherein, described rose-red carrier material can be any one or a few the mixture in the composite formed of synthesized polymer material, natural macromolecular material and synthesized polymer material and natural macromolecular material.
The mixture of any one or a few in described natural macromolecular material such as amniotic membrane, collagen, cellulose, chitin, chitosan, glycosaminoglycans and the alginate.
The mixture of any one or a few in described natural polymer material such as polyurethane, polyglycolic acid, polylactic acid (especially Poly-L-lactic acid), polycaprolactone, the polyester or the copolymer of above-mentioned polymer monomer.The mixture of described natural polymer or copolymer such as glycolic-lactic acid copolymer, poly-ethanol/polylactic acid blend, polyethylene terephthalate/polybutylene terephthalate blend, ethylene glycol terephthalate-polybutylene terephthalate copolymer.
Blend such as polycaprolactone/collagen/lactic acid-ethanol copolymer/glucosan blend that described synthesized polymer material and natural macromolecular material are formed.
Sew up a kind of preferred implementation of repairing the stricture of ureter surgery systems according to of the present invention exempting from, described 532nm laser transmitting set unit are irradiation power is 0.2～1W/cm
2, 0.2～0.8W/cm more preferably
2, as 0.2W/cm
2, 0.4W/cm
2, 0.5W/cm
2, 0.6W/cm
2, 0.8W/cm
2
Material and the system that exempts to sew up the operation of reparation stricture of ureter provided by the invention, only need laser illumination a few minutes just can finish the operation of repairing stricture of ureter fast, and avoided the operating microscope, microsurgery equipment and the particular procedure technical ability that need in the conventional suture operation, can implement in the technical merit backward areas; Avoided complicated operation simultaneously, speed is obviously accelerated, and reduces the patient suffering, reduces the complication of anesthesia occurrence probability and saves Anesthetic Fee usefulness; And can significantly reduce the occurrence probability of postoperative restenosis.
The specific embodiment
The invention provides a kind of be used to exempting to sew up the material of repairing the stricture of ureter operation, and described preparation methods and the system that exempts to sew up the operation of reparation stricture of ureter that comprises described material, based on this, the present invention also provides a kind of and has rose-redly exempted to sew up the material of repairing the stricture of ureter operation and the application in the system.Described exempting from sewed up the material of repairing the stricture of ureter operation, comprising rose-red and rose-red carrier.
Wherein, described rose-red carrier is preferably solid carrier, as thin film, and biomembrane especially.
Wherein, described rose-red carrier material can be any one or a few the mixture in the composite formed of synthesized polymer material, natural macromolecular material and synthesized polymer material and natural macromolecular material.
The mixture of any one or a few in described natural macromolecular material such as amniotic membrane, collagen, cellulose, chitin, chitosan, glycosaminoglycans and the alginate.
The mixture of any one or a few in described natural polymer material such as polyurethane, polyglycolic acid, polylactic acid (especially Poly-L-lactic acid), polycaprolactone, the polyester or the copolymer of above-mentioned polymer monomer.The mixture of described natural polymer or copolymer such as glycolic-lactic acid copolymer, poly-ethanol/polylactic acid blend, polyethylene terephthalate/polybutylene terephthalate blend, ethylene glycol terephthalate-polybutylene terephthalate copolymer.
Blend such as polycaprolactone/collagen/lactic acid-ethanol copolymer/glucosan blend that described synthesized polymer material and natural macromolecular material are formed.
Describedly exempt to sew up the system of repairing the stricture of ureter operation and also comprise the 532nm laser transmitting set.
Below by specific embodiment, the present invention is used for exempting to sew up material, the described preparation methods of repairing the stricture of ureter operation and comprises exempting to sew up the system of repairing the stricture of ureter operation and rose-redly being described in detail and describing exempting to sew up the material of repairing the stricture of ureter operation and the application of system of described material, so that understand the present invention better, but should be understood that following embodiment does not limit the scope of the invention.
Embodiment 1
Be the rose-red material that carries with Poly-L-lactic acid, area (1.5x2) cm
2, to contaminate more than the 0.07% rose-red solution 5min, lucifuge is stand-by.
After the stricture of ureter section excision, implant flexible pipe, the broken ends of fractured bone is involutory, superscribe at apposition position and to carry rosy Poly-L-lactic acid, the 532nm laser transmitting set carried out laser irradiation local 5 minutes 40 seconds, and parameter 0.3W/cm is set
2
Finish identically, operation finishes.
Use on the wound surface rose-red after, rose-red molecule Stimulated Light activates the inner occurred conformation in back and changes, thereby makes the rose-red excited state that is changed to, and is labile state.After collagen molecules meets in these unsettled excited state molecules and the tissue, electron transfer takes place between the rose-red and tropocollagen molecule of excited state, be formed with the tropocollagen molecule of positive or negative polarity, have in the tissue and form covalently cross-linked combination between the tropocollagen molecule of polarity, thereby cause connection and bonding fast and effectively between tissue, reach the effect of closure of wound.This reaction is for photochemical reaction process, is exothermal process not, and the tissue local temperature will can not raise, thereby to the histiocyte not damaged; Because this process is the connection between tropocollagen molecule, and its tightness degree can reach the degree of waterproof closure, tissue adhesion degree height.
And rose-red and laser equipment is the material and facility that is applied to clinical other treatment of state food medicine Supervision Bureau approval, does not have cytotoxicity and other risks.
Embodiment 2
Be the rose-red material that carries with amniotic membrane, area (1.5x2) cm
2, to contaminate more than the 0.1% rose-red solution 3min, lucifuge is stand-by.
After the stricture of ureter section excision, implant flexible pipe, the broken ends of fractured bone is involutory, superscribe at apposition position and to carry rosy amniotic membrane, the 532nm laser transmitting set carried out laser irradiation local 3 minutes 20 seconds, and parameter 0.4W/cm is set
2
Finish identically, operation finishes.
Embodiment 3
Be the rose-red material that carries with polycaprolactone/collagen/lactic acid/ethanol copolymer/glucosan blend, area (1.5x2) cm
2, to contaminate more than the 0.15% rose-red solution 3.5min, lucifuge is stand-by.
After the excision of stricture of ureter section, implant flexible pipe, the broken ends of fractured bone is involutory, superscribe at apposition position and to carry rosy polycaprolactone/collagen/lactic acid/ethanol copolymer/glucosan blend, the 532nm laser transmitting set carried out laser irradiation local 4 minutes, and parameter 0.5W/cm is set
2
Finish identically, operation finishes.
Embodiment 4
Be the rose-red material that carries with polyurethane, area (1.5x2) cm
2, to contaminate more than the 0.05% rose-red solution 4min, lucifuge is stand-by.
After the stricture of ureter section excision, implant flexible pipe, the broken ends of fractured bone is involutory, superscribe at apposition position and to carry rosy polyurethane, the 532nm laser transmitting set carried out laser irradiation local 3 minutes 45 seconds, and parameter 0.8W/cm is set
2
Finish identically, operation finishes.
Embodiment 5
Be the rose-red material that carries with glycosaminoglycans, area (1.5x2) cm
2, to contaminate more than the 0.2% rose-red solution 1min, lucifuge is stand-by.
After the stricture of ureter section excision, implant flexible pipe, the broken ends of fractured bone is involutory, superscribe at apposition position and to carry rosy glycosaminoglycans, the 532nm laser transmitting set carried out laser irradiation local 5 minutes 22 seconds, and parameter 0.2W/cm is set
2
Finish identically, operation finishes.
In the above embodiment of the present invention, repair material and the system that stricture of ureter is performed the operation with rose-red be used to exempting to sew up, prepare and exempt to sew up material and the system of repairing the stricture of ureter operation, and be used for the zooperal reparation stricture of ureter operation of exempting to sew up.
In the stricture of ureter animal model of preparation, use the above embodiment of the present invention to prepare and exempt to sew up material and the system of repairing the stricture of ureter operation, exempt to sew up and repair the stricture of ureter operation, do not find cytotoxicity after the operation, serious inflammatory reaction almost do not occur; And finish wound closure with other laser welding technology and compare, the present invention can not cause and organize the hot injury, does not find ureter restenosis phenomenon yet.
More than specific embodiments of the invention are described in detail, but it is just as example, the present invention is not restricted to specific embodiment described above.To those skilled in the art, any equivalent modifications that the present invention is carried out and substituting also all among category of the present invention.Therefore, not breaking away from impartial conversion and the modification of doing under the spirit and scope of the present invention, all should contain within the scope of the invention.
Claims (9)
1. exempt to sew up reparation stricture of ureter surgical material for one kind, it is characterized in that, the described stitching reparation stricture of ureter surgical material of exempting from comprises rose-red and rose-red carrier.
2. according to claim 1ly exempt from sew up to repair the stricture of ureter surgical material, it is characterized in that described rose-red carrier is any one or a few the mixture in the composite formed of synthesized polymer material, natural macromolecular material and synthesized polymer material and natural macromolecular material.
3. according to claim 2ly exempt from sew up to repair the stricture of ureter surgical material, it is characterized in that described natural macromolecular material is any one or a few the mixture in amniotic membrane, collagen, cellulose, chitin, chitosan, glycosaminoglycans and the alginate.
4. according to claim 2ly exempt from sew up to repair the stricture of ureter surgical material, it is characterized in that, described synthesized polymer material be in polyurethane, polyglycolic acid, polylactic acid, polycaprolactone, the polyester any one or a few mixture or the copolymer of above-mentioned polymer monomer.
5. rose-redly exempting to sew up the application of repairing in the stricture of ureter surgical material for one kind.
6. one kind prepares the described method of exempting to sew up reparation stricture of ureter surgical material of claim 1, it is characterized in that, with rose-red solution impregnation photosensitizer carrier, dry then.
7. application according to claim 6 is characterized in that, rose-red solution concentration is 0.05～0.2%.
8. one kind comprises the described system that exempts to sew up the reparation stricture of ureter that exempts to sew up reparation stricture of ureter material of claim 1, it is characterized in that, comprises 532nm laser transmitting set, rose-red and rose-red carrier.
9. according to claim 8 exempting from sewed up the system of repairing stricture of ureter, it is characterized in that described 532nm laser transmitting set unit are irradiation power is 0.2～1W/cm
2
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| CN2012100234429A CN103239763A (en) | 2012-02-02 | 2012-02-02 | Sutureless ureterostenosis restoration operation material and system thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012100234429A CN103239763A (en) | 2012-02-02 | 2012-02-02 | Sutureless ureterostenosis restoration operation material and system thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107106721A (en) * | 2014-10-10 | 2017-08-29 | 奥托细胞有限公司 | Sutureless Repair of Soft Tissue |
| CN108451637A (en) * | 2018-03-01 | 2018-08-28 | 周玉梅 | A kind of puncture needle and stitching devices |
Citations (2)
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| CN108451637A (en) * | 2018-03-01 | 2018-08-28 | 周玉梅 | A kind of puncture needle and stitching devices |
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