CN102920810A - A mucous membrane care product for Behcet's syndrome - Google Patents

Abstract

The present invention discloses a mucosal care product for Behçet's syndrome, belonging to the field of gynecological nursing and medical treatment, and is used to solve the problem of mucosal ulcers in Behçet's syndrome. It is characterized by being processed from multiple traditional Chinese medicines, and its raw material formula and weight ratio are: 6-10 parts of cat's claw, 8-15 parts of white medicine seeds, 8-15 parts of Ardisia japonica, 6-10 parts of scutellaria baicalensis, 6-10 parts of peach gum, 8-15 parts of earthworms, 6-10 parts of beeswax, 8-15 parts of Radix Astragali, and 3-6 parts of serpent stone. Clinical experiments have shown that the present invention has the characteristics of good efficacy and high safety for Behçet's syndrome, and is worthy of clinical application and promotion.

Description

A mucous membrane care product for Behcet's syndrome

technical field

The invention relates to the field of gynecological nursing and medical care, in particular to a mucosal care product for Behcet's syndrome.

Background technique

Behcet's syndrome (Behcet's disease, BD) is a systemic, chronic, vasculitic disease. Clinically, oral ulcers, genital ulcers, ophthalmia and skin lesions are the prominent manifestations, also known as mouth-eye-genital syndrome (Behcet syndrome). The disease often involves the nervous system, digestive tract, lung, kidney, epididymis and other organs. The disease was first reported by Behcet, a Turkish dermatologist, and has since been found all over the world. The incidence of this disease in Japan, North Korea, China, the Middle East (Turkey, Iran) and the Eastern Mediterranean is far higher than that in Western European and American countries. The age of onset of the disease is mostly young adults aged 16 to 40, and women account for a slight majority in China.

The etiology of the disease is not clear, and infection, heredity, and immune abnormalities have been proved to be related to the disease. Lesions mainly erode arterioles, venules, and microvessels. Infiltration of lymphocytes and monocytes, necrosis, expansion, and rupture of vessel walls can be seen in lesioned vessels and surrounding tissues, and intraluminal thrombosis or fibrous hyperplasia causes luminal stenosis , the pathological changes can involve systemic blood vessels, such as skin mucous membranes, eyes, and small vasculitis of multiple systems throughout the body, and most cases are also accompanied by joint symptoms of varying degrees.

Mouth and genital ulcers are the first symptoms of BD. More than 98% of patients can see oral ulcers, and 80% of patients can see genital ulcers. Ulcers manifest as red nodules on the buccal mucosa, edge of the tongue, lips, soft palate, and genitals, followed by ulceration, and the diameter of the ulcer is generally 2 to 3 mm. Some have herpes onset, subsided in about 14 days, and oral ulcers do not leave scars, but genital ulcers may be left with scars due to repeated attacks or persistent unhealed for several weeks. In the active stage, recurrent oral ulcers show up at least 3 times a year, and ulcers come and go. The female genital ulcers are mainly seen in the labia majora and minora, followed by the vagina, and can also appear around the perineum or anus, and the pain symptoms are more obvious.

The treatment of this disease is currently mainly based on non-steroidal anti-inflammatory drugs, glucocorticoids, and even the use of immunosuppressants such as colchicine or cyclophosphamide. For mucosal ulcers, gentian violet is generally used for oral ulcers, and 0.1% fludrysone acetate ointment or tetracycline ointment is generally used for genital ulcers. If the ulcers are serious, thalidomide (thalidomide) should be taken orally. However, the use of the above drugs is only for the infection associated with the ulcer, and cannot solve the problem of pain on the ulcer surface, and the use of hormone-based mucosal care products is likely to cause disadvantages such as rapid skin hardening and pigmentation.

Therefore, there is still a lack of a mucosal care product that can relieve the pain of Behcet's syndrome mucosal ulcer and promote the healing of the ulcer.

Contents of the invention

The technical task of the present invention is to provide a mucous membrane care product for Behcet's syndrome with positive curative effect and relatively few side effects against the above deficiencies in the prior art.

The technical scheme for solving the technical problems of the present invention is: a mucous membrane care product for Behcet's syndrome, which is characterized in that it is processed from a variety of traditional Chinese medicines, and its raw material formula and weight ratio are: Cat's Claw 6~ 10 parts, 8~15 parts of Baiyaozi, 8~15 parts of Zijinniu, 6~10 parts of Shilongrui, 6~10 parts of peach gum, 8~15 parts of earthworm, 6~10 parts of beeswax, 8~15 parts of radish parts, snake contains 3~6 parts of stone.

The optimal weight ratio is: 8 parts of cat's claw grass, 10 parts of Baiyaozi, 10 parts of Zijinniu, 8 parts of Shilongrui, 8 parts of peach gum, 10 parts of earthworm, 8 parts of beeswax, 10 parts of radish, snake Contains 5 parts of stone.

The optimization scheme is to add 3 parts of cat's eye grass on the basis of the above.

Wherein said: cat's claw grass, is the dry tuberous root of Ranunculus ternatus Thunb. of Ranunculaceae plant. Nature and flavor are sweet, pungent, warm. Return liver, lung meridian. Function can dissipate stagnation and detumescence.

Baiyaozi is Stephania cephalantha Hayata, the head flower of Stephania cephalantha Hayata, which is used as medicine with tubers. Nature and flavor are bitter, cold. Function can clear heat and detoxify, cool blood to stop bleeding, dissipate blood stasis and reduce swelling.

Zijinniu is Ardisia japonica (Hornsted) Blume, a plant of the genus Zijinniu in the family Zijinbu. It is used as medicine with the whole plant. Nature and flavor are pungent, flat. The function can relieve cough and reduce phlegm, dispel wind and detoxify, promote blood circulation and relieve pain.

Shi Longrui, Ranunculus sceleratus L., is a plant of Ranunculaceae Ranunculus genus Ranunculus sceleratus L., the whole herb is used as medicine. Nature and flavor are bitter, pungent, flat. poisonous. The function can reduce swelling, expel toxins and dissipate stagnation, and cut malaria.

Peach gum is the resin that flows from the trunk of Prunus persica (L.) Batsch, a plant in the Rosaceae family. Nature and flavor are bitter, flat. Gong can activate blood, replenish qi, and quench thirst.

Earth Dragon, is the dried body of Pheretima aspergillum (E. Perrier), Pheretima vulgaris Chen, Pheretima guillelmi (Michaelsen) or Pheretima pectinifera Michaelsen, Nature and flavor are bitter, flat, and its functions can clear away heat, calm the liver, relieve asthma, and dredge collaterals.

Beeswax is the wax secreted by Apis cerana Fabricius or Italian bee Apis mellifera Linnaeus. Nature and flavor are sweet, tepor. Gong can be astringent, suppress sores, promote granulation, and relieve pain.

Radix radix, is Radix Radix Metaplexis japonica (Thunb.) Makino, a plant of the genus Radix Radix genus Radix, which is used as medicine with tubers and whole plants. Nature and flavor are sweet, slightly pungent, warm. Gong can invigorate qi and benefit essence, promote qi and blood circulation, reduce swelling and detoxify.

Snake contains stone, which is the nodules of the oxide mineral limonite Pyrite; Limonite. Sweet in nature and flavor; cold. GUI Xinbao; Liver Channel. The function can soothe the nerves and calm convulsions; stop bleeding and relieve pain.

Cat's-eye grass is the whole plant of Euphorbia lunulata Bunge, a plant of Euphorbia genus Euphorbia. Nature and flavor are bitter, cool. Function can promote diuresis, detumescence, detoxify and relieve itching.

Prescription principle: Behcet's syndrome is a systemic, chronic, vascular inflammatory disease. The etiology of the disease is not clear, and it may be related to factors such as infection, heredity, environment, and abnormal immune function. Lesions mainly erode arterioles, venules, and microvessels. Infiltration of lymphocytes and monocytes, necrosis, expansion, and rupture of vessel walls can be seen in lesioned vessels and surrounding tissues, and intraluminal thrombosis or fibrous hyperplasia causes luminal stenosis , the pathological changes can involve systemic blood vessels, such as skin mucous membranes, eyes, and small vasculitis of multiple systems throughout the body, and most cases are also accompanied by joint symptoms of varying degrees. Traditional Chinese medicine treatment often starts with heat-clearing and dehumidification, but the inventor's many years of clinical experience believes that this disease belongs to the combination of internal and external causes, and the toxin spreads throughout the body.

Compared with the prior art, the present invention has the following characteristics:

1. The formula is unique: take Cat's Claw to Sanjie, Baiyaozi to clear away heat and detoxify, and Zijinniu to dispel wind and detoxify. The three cooperate to start with evil wind and heat toxin respectively, and solve the mucosal ulcer caused by local vascular wall necrosis. After the inventor After many years of clinical exploration, it has been found that the combination of these three herbs can effectively solve the cause of the ulcer - small vasculitis, that is, the cause of the disease must seek its root;

2. Taking into account both specimens: cat's claw grass, baiyaozi, and Zijinniu are the medicines for the root cause, and the pain caused by mucosal ulcers can be cured by Zijinniu promoting blood circulation and relieving pain, beeswax astringing sores, promoting granulation and relieving pain, and snake containing stones to stop bleeding and relieve pain. If the pain is severe, cat’s eye grass is added to the optimized plan to remove poison and relieve itching, and start from multiple angles to achieve the effect of rapid pain relief. This combination of painkillers is obtained by the inventor for many years, and it is specific to mucosal ulcers;

3. The effect of mucosal repair is rapid: the in vitro test of the decoction of cat's claw grass, Shilongrui and Dilong three medicines has proved that it can promote the ability of mucosal repair, and this kind of mucosal repair ability is not completed by dilating blood vessels and increasing local blood supply. , but by increasing the stability of the cell membrane of the new capillary wall cells, that is, the new blood vessels are no longer infiltrated by lymphocytes and monocytes and have pathological effects;

4. The use of earthworm, a meridian dredging drug, increases the local diffusion rate of the drug, and the local area is non-irritating;

5. Peach gum and beeswax can form a protective film on the surface of the mucous membrane, making the ulcer surface of the vaginal mucous membrane less prone to contamination and secondary infection, thus contributing to healing;

6. BD belongs to deficiency in origin and excess in superficiality, so peach tree gum is used locally to replenish qi and radish to invigorate qi and essence. The local absorption effect of these two medicines is better than that of astragalus, codonopsis pilosula, and sand ginseng;

7. Pay attention to local ion balance: the composition of snake stones is ferric oxide containing water, and various trace elements such as manganese, phosphorus, calcium, vanadium, etc. The research results of the inventors show that adding this medicine in the prescription is beneficial to promote mucous membrane Repair, it may be related to local ion imbalance due to the onset of BD;

8. Avoid the use of heat-clearing and damp-removing drugs, because most of the heat-clearing and damp-removing drugs are dry, and the short-term effect is good, but the long-term prognosis is poor and the recurrence rate is high;

9. Avoid the use of drugs that have the effect of dilating blood vessels. The reason is that dilating blood vessels will also lead to increased permeability of capillary walls. The pathological basis of BD itself is necrosis, expansion, and rupture of blood vessel walls, followed by intraluminal thrombosis or fibrous hyperplasia. Causes luminal stenosis, dilating blood vessels can temporarily relieve luminal stenosis, but instead increases the burden on the vascular wall;

10. The dosage of the raw materials of the mucous membrane care product of the present invention is obtained through a lot of exploration by the inventor, and the dosage of each raw material has a good curative effect in the following parts by weight.

Detailed ways

The specific implementation manner of the present invention will be described in detail below in combination with the actual situation.

Example 1, the weight ratio of raw materials: Cat's claw grass 6g, Baiyaozi 8g, Zijinniu 8g, Shilongrui 6g, peach gum 6g, earthworm 8g, beeswax 6g, radish 8g, snake containing stone 3g.

Example 2, the weight ratio of raw materials: cat's claw grass 10g, Baiyaozi 15g, Zijinniu 15g, Shilongrui 10g, peach gum 10g, earthworm 15g, beeswax 10g, radish 15g, snake containing stone 6g.

Example 3, the weight ratio of raw materials: cat's claw grass 8g, Baiyaozi 10g, Zijinniu 10g, Shilongrui 8g, peach gum 8g, earthworm 10g, beeswax 8g, radish 10g, snake containing stone 5g.

When using Examples 1 to 3, add water to decoct the Chinese medicine Cat's Claw Grass, Baiyaozi, Zijinniu, Shilongrui, Earthworm, Shehanshi and Radix Radix for two times, combine the filtrate, add peach gum, Beeswax, after concentrated, is applied locally on the vaginal mucosa in the morning and evening.

Example 4, the weight ratio of raw materials: cat's claw grass 6g, Baiyaozi 8g, Zijinniu 8g, Shilongrui 6g, peach gum 6g, earthworm 8g, beeswax 6g, radish 8g, snake containing stone 3g, cat's eye grass 2g.

Example 5, the weight ratio of raw materials: cat's claw grass 10g, Baiyaozi 15g, Zijinniu 15g, Shilongrui 10g, peach gum 10g, earthworm 15g, beeswax 10g, radish 15g, snake containing stone 6g, cat's eye grass 2g.

Example 6, the weight ratio of raw materials: cat's claw grass 8g, Baiyaozi 10g, Zijinniu 10g, Shilongrui 8g, peach gum 8g, earthworm 10g, beeswax 8g, radish 10g, snake containing stone 5g, cat's eye grass 2g.

When embodiment 4～6 is used, Chinese medicine cat's claw of the present invention, Baiyaozi, Zijinniu, Shilongrui, Dilong, Shehanshi, radish and cat's eye grass are decocted twice, and the combined filtrate is heated. Add peach gum and beeswax, concentrate, apply to vaginal mucosa in the morning and evening.

In addition to the above preparation methods, the above embodiments can be combined with existing pharmaceutical methods to make ointments and creams for local use.

The effective combination and mutual coordination of the above-mentioned mucosal care products can effectively relieve the pain of Behcet's syndrome mucosal ulcer, promote ulcer healing, and have fewer side effects. The above results are fully proved by the clinical data, and the relevant data are as follows, wherein the weight ratio of the bulk drug in Example 3 and Example 6 is used for the research on mucosal care.

1 Objects and methods.

1.1 Subject.

1.1.1 Inclusion criteria: female patients with Behcet's syndrome and recurrent genital ulcer diagnosed between January 2009 and September 2012, the recurrent refers to at least 3 repeated attacks within one year. The nutritional status of each case was good, and the blood sugar, blood fat, liver and kidney functions were all within the normal range.

1.1.2 Diagnosis basis of Behcet’s syndrome: recurrent oral ulcers (including mild small ulcers, relatively heavy large ulcers or herpetic ulcers), and any two of the following four items occur sequentially or simultaneously: ① Recurrent genital ulcers or scars: must be observed by a physician or provided by the patient himself and confirmed to be reliable; ②Eye damage: including anterior uveitis and posterior uveitis, vitreous opacity or retinal blood vessels found during slit lamp examination ③Skin lesions: including erythema nodosum, pseudofolliculitis and purulent papules, acne-like nodules in non-adolescents who have not used glucocorticoids; Positive reaction judged by physician after 48 hours.

1.1.3 Cases: 60 cases were selected, ranging in age from 16 to 41 years, with an average age of 28.13±9.62 years.

1.2 Method.

1.2.1 Grouping: 60 cases were selected and divided into 30 cases in the control group and 30 cases in the treatment group. There was no significant difference in age between the two groups, P>0.05, which was comparable.

1.2.2 Research method: the control group used 0.1% fludrylprednisolone acetate ointment locally, the treatment group used the drug in Example 3 of the present invention for external use, and those with severe pain in the acute phase used the drug obtained in Example 6 for external use. All cases were administered twice a day for 10 days.

1.2.3 Safety evaluation: Blood, urine and feces routine, liver and kidney function, and electrocardiogram were monitored before and after the drug.

1.2.4 Statistical analysis: SPSS 13.0 was used for statistical analysis, and P<0.05 indicated significant significance.

2 results.

2.1 Comparison of curative effects between the two groups: the pain was significantly reduced or relieved. After 10 days of treatment, the cure rate (33.3%) and markedly effective rate (60.0%) of the treatment group were significantly higher than those of the control group (10.0%) and markedly effective rate (10.0%). Statistically significant (p<0.05).

2.2 Pain relief time of the effective cases in the two groups: Among the effective cases, the average pain relief time of the treatment group was 4.11±1.08d, and that of the control group was 7.32±3.17d. Compared with the two groups, the treatment group was significantly better than the control group (p<0.01).

2.3 Adverse reactions: No obvious adverse reactions were recorded in the two groups.

2.4 Recurrence rate: Follow up the cases for 1 year, within 1 year, 30.00% (9/30) of the treatment group relapsed, and 63.33% (19/30) of the control group relapsed. Comparing the two, the recurrence rate of the treatment group was significantly lower than that of the control group (p <0.01).

3. in conclusion.

The results of this study suggest that the present invention has the characteristics of good curative effect and high safety when used for Behcet's syndrome, and is worthy of clinical application and promotion.

Claims (3)

1. mucomembranous nursing thing that is used for Behcet's syndrome, it is characterized in that being processed by plurality of Chinese, its composition of raw materials and weight proportion are: 6 ~ 10 parts of Radix Ranunculi Ternatis, 8 ~ 15 parts of Radix Stephaniae Cepharanthaes, 8 ~ 15 parts of Herba Ardisiae Japonicaes, 6 ~ 10 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 6 ~ 10 parts of gumshiraz, 8 ~ 15 parts of Pheretimas, 6 ~ 10 parts in Cera Flava, 8 ~ 15 parts of Herba seu radix metaplexis, 3 ~ 6 parts of Limonitums.

2. a kind of mucomembranous nursing thing for Behcet's syndrome according to claim 1 is characterized in that its weight proportion is: 8 parts of Radix Ranunculi Ternatis, 10 parts of Radix Stephaniae Cepharanthaes, 10 parts of Herba Ardisiae Japonicaes, 8 parts of Herba Ranunculi Scelerati (Radix Anemones rupicolae)s, 8 parts of gumshiraz, 10 parts of Pheretimas, 8 parts in Cera Flava, 10 parts of Herba seu radix metaplexis, 5 parts of Limonitums.

3. a kind of mucomembranous nursing thing for Behcet's syndrome according to claim 1 is characterized in that: comprise that also weight proportion is 3 parts Herba euphorbiae lunulatae.