CN102846408B - Metallic granular body for bone-grafting filling - Google Patents
Metallic granular body for bone-grafting filling Download PDFInfo
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- CN102846408B CN102846408B CN201110178167.3A CN201110178167A CN102846408B CN 102846408 B CN102846408 B CN 102846408B CN 201110178167 A CN201110178167 A CN 201110178167A CN 102846408 B CN102846408 B CN 102846408B
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- 238000011049 filling Methods 0.000 title claims abstract description 53
- 210000000988 bone and bone Anatomy 0.000 claims abstract description 133
- 239000008187 granular material Substances 0.000 claims abstract description 40
- 229910052751 metal Inorganic materials 0.000 claims description 40
- 239000002184 metal Substances 0.000 claims description 40
- 239000002923 metal particle Substances 0.000 claims description 29
- 229910052588 hydroxylapatite Inorganic materials 0.000 claims description 8
- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 7
- 238000000576 coating method Methods 0.000 claims description 7
- 239000002245 particle Substances 0.000 claims description 7
- 229910000861 Mg alloy Inorganic materials 0.000 claims description 4
- 229910001069 Ti alloy Inorganic materials 0.000 claims description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims description 4
- 239000000945 filler Substances 0.000 claims description 4
- 239000011148 porous material Substances 0.000 claims description 4
- 229910001220 stainless steel Inorganic materials 0.000 claims description 4
- 239000010935 stainless steel Substances 0.000 claims description 4
- 239000010936 titanium Substances 0.000 claims description 4
- 229910052719 titanium Inorganic materials 0.000 claims description 4
- 229910000531 Co alloy Inorganic materials 0.000 claims description 3
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims 1
- 230000007547 defect Effects 0.000 abstract description 13
- 239000007943 implant Substances 0.000 abstract description 6
- 238000000034 method Methods 0.000 abstract description 4
- 239000000203 mixture Substances 0.000 abstract 2
- 230000004071 biological effect Effects 0.000 abstract 1
- 210000004409 osteocyte Anatomy 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 description 14
- 239000002639 bone cement Substances 0.000 description 10
- 230000000735 allogeneic effect Effects 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 238000004070 electrodeposition Methods 0.000 description 8
- 238000003672 processing method Methods 0.000 description 8
- 230000007797 corrosion Effects 0.000 description 6
- 238000005260 corrosion Methods 0.000 description 6
- 238000010894 electron beam technology Methods 0.000 description 6
- 238000005245 sintering Methods 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 210000002449 bone cell Anatomy 0.000 description 5
- 238000005553 drilling Methods 0.000 description 4
- 150000002739 metals Chemical class 0.000 description 4
- 210000004204 blood vessel Anatomy 0.000 description 3
- 238000005266 casting Methods 0.000 description 3
- 238000005520 cutting process Methods 0.000 description 3
- 238000005242 forging Methods 0.000 description 3
- 230000000399 orthopedic effect Effects 0.000 description 3
- 238000005507 spraying Methods 0.000 description 3
- 229910052715 tantalum Inorganic materials 0.000 description 3
- -1 tantalum metals Chemical class 0.000 description 3
- 208000010392 Bone Fractures Diseases 0.000 description 2
- 230000000975 bioactive effect Effects 0.000 description 2
- 230000010261 cell growth Effects 0.000 description 2
- 238000009760 electrical discharge machining Methods 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 241000589970 Spirochaetales Species 0.000 description 1
- 229910045601 alloy Inorganic materials 0.000 description 1
- 239000000956 alloy Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005234 chemical deposition Methods 0.000 description 1
- 230000009193 crawling Effects 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 238000003754 machining Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000002271 resection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
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- Health & Medical Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
Abstract
Description
技术领域 technical field
本发明涉及骨科手术植入体，特别是一种用于骨缺损填充的植骨填充金属颗粒体。The invention relates to an orthopedic surgical implant, in particular to a bone graft filling metal granule used for bone defect filling.
背景技术 Background technique
在各种骨科切除治疗、人工关节置换、正畸手术等会遇到不同程度的骨缺损的问题，以往常规的解决方法是使用自体骨或异体骨的骨块、骨颗粒、骨泥等将缺损部位进行填充塑形，再植入相应的假体或固定用器械以完成手术，但由于自体骨来源有限，异体骨价格昂贵且有生物学方面的风险，因此并不是每一位需要进行骨缺损填充的患者都能够得到满意的治疗。In various orthopedic resections, artificial joint replacements, orthodontic surgeries, various degrees of bone defects are encountered. In the past, the conventional solution was to use autologous or allogeneic bone blocks, bone granules, and bone paste to remove the defects. However, due to the limited source of autologous bone, the price of allogeneic bone is expensive and there are biological risks, so not everyone needs bone defect Filled patients can get satisfactory treatment.
发明内容 Contents of the invention
本发明的目的是提供一种植骨填充金属颗粒体，手术时可根据需要将一定数量的植骨填充金属颗粒体与自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌用于骨缺损填充，以占位形式部分替代自体骨或异体骨填充物，患者康复过程中骨细胞与微细血管向植骨填充金属颗粒体内部长入，可以形成融合嵌入式的生物活性骨修复体。The purpose of the present invention is to provide a bone graft filling metal granule body. During the operation, a certain amount of bone graft filling metal granule body can be mixed and stirred with autologous bone or allogeneic bone bone block, bone granule and bone paste for bone defect. Filling, which partially replaces autologous bone or allogeneic bone filler in the form of a space-occupying, bone cells and tiny blood vessels grow into the bone graft filling metal particles during the patient's rehabilitation process, and can form a fusion-embedded bioactive bone restoration.
为实现上述目的，本发明采取以下设计方案：To achieve the above object, the present invention takes the following design scheme:
植骨填充金属颗粒体，其特征在于，该颗粒体形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外形尺寸为2～15mm，使用时将适当数量的植骨填充金属颗粒体与自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌后填充于骨缺损部位。Bone graft filling metal granules, characterized in that the granules are in the shape of spheres, cylinders, polyhedrons, helices, meshes, and combinations of the aforementioned various shapes, and the outer dimensions of the granules are 2 to 15mm. When mixing and stirring an appropriate amount of bone graft filling metal granules with autologous or allogeneic bone, bone granules, and bone paste, they are filled in the bone defect.
所述植骨填充金属颗粒体其特征在于，在植骨填充金属颗粒体上设有容纳植入碎骨颗粒或骨泥的植骨孔，植骨孔由植骨填充金属颗粒体的外表面向内延伸，植骨孔孔径1～10mm，各个植骨孔之间相互贯通相连。The bone graft filling metal granule is characterized in that a bone graft hole is provided on the bone graft filling metal granule to accommodate implanted bone crushed particles or bone paste, and the bone graft hole extends inwardly from the outer surface of the bone graft filling metal granule. The hole diameter of the bone grafting hole is 1-10mm, and each bone grafting hole is connected with each other.
所述植骨填充金属颗粒体其特征在于，该颗粒体的金属实体部分外表面及植骨孔内表面分布有相互连通的微孔隙，该微孔隙的孔径为50μm～900μm。The bone graft filling metal granule is characterized in that interconnected micropores are distributed on the outer surface of the metal entity part of the granule and the inner surface of the bone graft hole, and the diameter of the micropores is 50 μm to 900 μm.
所述植骨填充金属颗粒体其特征在于它采用医用金属制成，所述医用金属包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金。The bone graft filling metal granule is characterized in that it is made of medical metals, and the medical metals include titanium and titanium alloys, cobalt alloys, stainless steel, tantalum metals, and magnesium alloys.
所述植骨填充金属颗粒体表面全部或局部具有羟基磷灰石涂层，该羟基磷灰石涂层有诱导骨细胞生长的功能。The whole or part of the surface of the bone graft filling metal particles has a hydroxyapatite coating, and the hydroxyapatite coating has the function of inducing bone cell growth.
所述植骨填充金属颗粒体的加工方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，特别是激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术除可以制作植骨填充金属颗粒体的金属实体外同时还能够在该实体表面及植骨孔内表面生成相互连通的微孔隙；羟基磷灰石涂层则通过高温喷涂或电化学沉积得到。The processing methods of the bone graft filling metal particles are: forging, casting, mechanical cutting and drilling, electrical discharge machining, etc.; other processing methods also include laser or high-energy electron beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electric Chemical deposition and other technologies, especially laser or high-energy electron beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electrochemical deposition and other technologies can not only make metal entities filled with bone graft metal particles, but also can be used on the surface of the entity and bone graft. Interconnected micropores are formed on the inner surface of the pores; the hydroxyapatite coating is obtained by high-temperature spraying or electrochemical deposition.
本发明的优点是：The advantages of the present invention are:
1.本发明植骨填充金属颗粒体，该颗粒体形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外部尺寸为2～15mm，在使用时形状、大小和数量有多种选择，配以自体骨或异体骨的骨块、骨颗粒、骨泥混合搅拌后能有效填充并充盈于各种形状的骨缺损部位。1. The bone graft of the present invention is filled with metal granules, the granules are in the form of spheres, cylinders, polyhedrons, spirals, reticular bodies, and combinations of the aforementioned various shapes, and the outer dimensions of the granules are 2 to 15 mm. There are many choices of shape, size and quantity when used. After mixing with autologous bone or allogeneic bone, bone granules, and bone paste, it can effectively fill and fill bone defects of various shapes.
2.本发明植骨填充金属颗粒体，在该颗粒体上设有容纳植入碎骨颗粒或骨泥的植骨孔，植骨孔由植骨填充金属颗粒体外轮廓向内延伸，植骨孔孔径1～10mm，各个植骨孔之间相互贯通相连；植骨填充金属颗粒体的植入方法是：手术中医生根据需要选择适当数量、大小和形状的植骨填充金属颗粒体与患者自体或异体碎骨颗粒及骨泥混合搅拌成混合植入物，必要时将碎骨颗粒及骨泥直接植入植骨填充金属颗粒体的植骨孔，然后将搅拌好的混合植入物装填于骨缺损处加压捣实以获得填充体的初始稳定，术后恢复期时缺损周围的骨质与植骨填充金属颗粒体植骨孔内的骨泥、碎骨颗粒融合生长成一体后即可达到长久有效地防止该植骨填充金属颗粒体发生松动的作用。由于使用植骨填充金属颗粒体部分替代自体骨和异体骨，可大大降低患者的经济负担并一定程度上克服了获取自体骨和异体骨的数量上的困难与不足；患者自体碎骨颗粒及骨泥可以在手术中通过必要的截骨、钻骨、破碎等操作过程得到。2. The bone graft filling metal particle body of the present invention is provided with a bone graft hole for implanting crushed bone particles or bone mud on the particle body. The bone graft hole extends inward from the outer contour of the bone graft filler metal particle, and the bone graft hole has an aperture diameter of 1 The implantation method of bone graft filling metal particles is as follows: the doctor selects appropriate quantity, size and shape of bone graft filling metal particles and the patient's autologous or allogeneic fragments according to the needs during the operation. Bone granules and bone paste are mixed and stirred to form a hybrid implant. If necessary, the crushed bone granules and bone paste are directly implanted into the bone graft hole of the bone graft to fill the metal particle body, and then the mixed implant is filled in the bone defect Pressurize and tamp to obtain the initial stability of the filling body. During the postoperative recovery period, the bone around the defect is fused with the bone paste and broken bone particles in the bone graft hole of the bone graft filling metal particles to achieve long-term effectiveness. It can effectively prevent the bone graft filling metal particles from loosening. Because the use of bone grafting to fill metal particles partially replaces autologous bone and allogeneic bone, it can greatly reduce the economic burden of patients and overcome the difficulties and shortages in the quantity of autologous bone and allogeneic bone to a certain extent; Mud can be obtained through necessary operations such as osteotomy, bone drilling, and crushing during the operation.
3.本发明植骨填充金属颗粒体，其特征在于，该颗粒体的金属实体部分外表面及植骨孔内表面分布有相互连通的微孔隙，该微孔隙与骨质紧密接触有利于骨细胞及血管的长入以获得长期稳定，该微孔隙的孔径为50μm～900μm，此种尺度的微孔隙有利于骨细胞与微细血管向植骨填充金属颗粒体内部爬行长入，可以形成融合嵌入式的生物活性骨修复体。3. The bone graft filling metal granule body of the present invention is characterized in that, the outer surface of the metal entity part of the granule body and the inner surface of the bone graft hole are distributed with interconnected micropores, and the close contact between the micropores and the bone is beneficial to bone cells. and the growth of blood vessels to obtain long-term stability. The pore size of the micropores is 50 μm to 900 μm. Micropores of this scale are conducive to the crawling and growth of bone cells and micro blood vessels into the bone graft filling metal particles, which can form fusion embedded bioactive bone restorations.
4.本发明植骨填充金属颗粒体，其特征在于，颗粒体表面全部或局部具有羟基磷灰石涂层，该羟基磷灰石涂层具有诱导骨细胞生长的功能。4. The bone graft filling metal granule of the present invention is characterized in that the surface of the granule is entirely or partially coated with hydroxyapatite, and the hydroxyapatite coating has the function of inducing bone cell growth.
5、本发明植骨填充金属颗粒体，其特征在于，颗粒体采用可用于植入人体的医用金属制成，包括钛及钛合金、钻合金、不锈钢以及钽金属、镁合金，此类金属材料的生物相容性已经得到国内外多年骨科植入应用的实践证实；所述植骨填充金属颗粒体的加工方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，特别是激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术除可以制作植骨填充金属颗粒体的金属实体外同时还能够在该实体表面及植骨空内表面生成相互连通的微孔隙；羟基磷灰石涂层则通过高温喷涂或电化学沉积得到；上述各种加工方法均已为金属加工行业公知的成熟技术，故本说明书中不做更多阐述。5. The bone graft filling metal granules of the present invention are characterized in that the granules are made of medical metals that can be implanted into the human body, including titanium and titanium alloys, diamond alloys, stainless steel, tantalum metals, and magnesium alloys. The biocompatibility of the biocompatibility has been confirmed by the practice of orthopedic implant applications at home and abroad for many years; the processing methods of the bone graft filling metal particles are: forging, casting, mechanical cutting and drilling, electric discharge machining, etc.; other processing methods are also Including laser or high-energy electron beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electrochemical deposition and other technologies, especially laser or high-energy electron beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electrochemical deposition and other technologies can make bone grafts The metal body filled with metal particles can also generate interconnected micropores on the surface of the body and the inner surface of the bone graft cavity; the hydroxyapatite coating is obtained by high-temperature spraying or electrochemical deposition; the above-mentioned various processing methods can be It is a well-known mature technology in the metal processing industry, so no further elaboration will be made in this specification.
附图说明 Description of drawings
图1为本发明实施例球体结构示意图Fig. 1 is the schematic diagram of the sphere structure of the embodiment of the present invention
图2为本发明实施例圆柱体结构示意图Fig. 2 is the schematic diagram of the cylinder structure of the embodiment of the present invention
图3为本发明实施例螺旋体结构示意图Fig. 3 is the schematic diagram of the structure of the spirochete of the embodiment of the present invention
图4为本发明实施例网状体结构示意图Figure 4 is a schematic diagram of the structure of the mesh body of the embodiment of the present invention
图5为本发明实施例多面体结构示意图Fig. 5 is the polyhedron structure schematic diagram of the embodiment of the present invention
图6、图7为本发明实施例各种形状体的组合体结构示意图Fig. 6 and Fig. 7 are schematic diagrams of the structure of the combination of various shapes in the embodiment of the present invention
图8为本发明实施例微孔隙放大示意图Figure 8 is an enlarged schematic diagram of the micropores of the embodiment of the present invention
图9为本发明实施例填充于骨缺损部位示意图Fig. 9 is a schematic diagram of the embodiment of the present invention filling bone defects
具体实施方式 Detailed ways
以下结合附图对本发明的具体实施做进一步详细说明。The specific implementation of the present invention will be described in further detail below in conjunction with the accompanying drawings.
如图1、图2、图3、图4、图5、图6、图7、所示，本发明植骨填充金属颗粒体(1)，其形状为球体、圆柱体、多面体、螺旋体、网状体、以及前述各种形状体的组合体，该颗粒体外部尺寸为2～15mm，在植骨填充金属颗粒体(1)上设有容纳植入碎骨颗粒或骨泥的植骨孔(2)，植骨孔(2)由植骨填充金属颗粒体(1)的外表面向内延伸，植骨孔(2)孔径1～10mm，各个植骨孔(2)之间相互贯通相连，如图8所示植骨填充金属颗粒体(1)金属实体部分的外表面及植骨孔(2)的内表面分布有相互连通的微孔隙(3)，该微孔隙(3)的孔径为50μm～900μm。As shown in Fig. 1, Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, the bone graft of the present invention is filled with metal particles (1), and its shape is sphere, cylinder, polyhedron, helix, net Shaped body, and the combination of the above-mentioned various shapes, the outer size of the granular body is 2-15 mm, and the bone grafting hole (1) is provided with a bone grafting hole ( 2), the bone graft hole (2) extends inwardly from the outer surface of the bone graft filling metal granule (1), the bone graft hole (2) has a diameter of 1-10mm, and the bone graft holes (2) are connected to each other, as shown in As shown in Figure 8, there are interconnected micropores (3) distributed on the outer surface of the metal solid part of the bone graft filling metal particle body (1) and the inner surface of the bone graft hole (2), and the pore diameter of the micropores (3) is 50 μm ~900 μm.
本发明植骨填充金属颗粒体(1)采用可用于植入人体的医用金属制成，包括钛及钛合金、钴合金、不锈钢以及钽金属、镁合金，其加工制作的方法是：锻造、铸造、机械切削钻孔、放电加工成型等；其他的加工方法还包括采用激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术，微孔隙(3)可以由激光或高能电子束快速成型技术、高温烧结、化学腐蚀、电化学沉积等技术加工得到，羟基磷灰石涂层则通过高温喷涂或电化学沉积得到；所述各种加工方法均已为金属加工行业公知的成熟技术。The bone graft filling metal granules (1) of the present invention are made of medical metals that can be implanted into the human body, including titanium and titanium alloys, cobalt alloys, stainless steel, tantalum metals, and magnesium alloys. The processing methods are: forging, casting , mechanical cutting and drilling, electrical discharge machining, etc.; other processing methods include the use of laser or high-energy electron beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electrochemical deposition and other technologies, micropores (3) can be formed by laser or high-energy electron beam Beam rapid prototyping technology, high-temperature sintering, chemical corrosion, electrochemical deposition and other technologies are processed, and the hydroxyapatite coating is obtained by high-temperature spraying or electrochemical deposition; the various processing methods are well-known and mature in the metal processing industry. technology.
如图9所示本发明植骨填充金属颗粒体使用时医生可以根据需要选择适当大小和形状的植骨填充金属颗粒体(1)安置在骨缺损处并通过打压将其固定在骨床上以获得该植骨填充金属颗粒体(1)的早期稳定；植骨填充金属颗粒体(1)在适当位置设有容纳植骨碎骨颗粒或骨泥的植骨孔(2)用于填充自体或异体的碎骨颗粒，此外在金属实体部分的外表面及植骨孔(2)的内表面分布有相互连通的微孔隙(3)，手术植入后待到外部骨组织渗透长入微孔隙(3)并与植骨孔(2)中填充的碎骨颗粒或骨泥融合生长成一体后即可达到长久有效地防止该植骨填充金属颗粒体(1)发生松动的目的。As shown in Figure 9, when the bone graft filling metal granule of the present invention is used, the doctor can select the bone graft filling metal granule (1) of appropriate size and shape according to the needs and place it on the bone defect and fix it on the bone bed by pressing to obtain The early stability of the bone graft filling metal particle body (1); the bone graft filling metal particle body (1) is provided with a bone graft hole (2) at an appropriate position for accommodating bone graft crushed bone particles or bone paste for filling autograft or allograft In addition, there are interconnected micropores (3) distributed on the outer surface of the metal solid part and the inner surface of the bone graft hole (2). After the operation is implanted, the external bone tissue penetrates and grows into the micropores (3). And after being fused and grown together with the broken bone particles or bone cement filled in the bone graft hole (2), the purpose of effectively preventing the bone graft filling metal particle body (1) from loosening can be achieved for a long time.
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| US10231841B2 (en) * | 2015-04-13 | 2019-03-19 | Marco LANZETTA | Prosthesis for the trapeze-metacarpal joint of the thumb |
| DE102015107600B4 (en) * | 2015-05-13 | 2017-08-10 | Heraeus Medical Gmbh | A particulate alloplastic bone substitute material and method of making a free formed porous body |
| CN105147417A (en) * | 2015-06-24 | 2015-12-16 | 中国人民解放军第四军医大学 | Bone grafting stent for acetabular osteotomy reconstruction |
| CN105327402B (en) * | 2015-11-19 | 2018-10-09 | 创生医疗器械（中国）有限公司 | 3D printing bone defect packing material |
| CN105476732A (en) * | 2015-12-31 | 2016-04-13 | 温州康诺克医疗器械有限公司 | Artificial bone grain |
| CN110037832B (en) * | 2019-04-16 | 2021-06-01 | 华南协同创新研究院 | A kind of composite unit structure porous scaffold for bone repair and processing method |
| CN113749831B (en) * | 2020-06-04 | 2024-04-26 | 上海凯利泰医疗科技股份有限公司 | Balloon scaffold, inflatable device and application thereof |
| CN111904668B (en) * | 2020-09-11 | 2025-03-28 | 王超 | Bone Graft Particles |
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