CN102814294A - Cleaning and drying device for biological chip - Google Patents
Cleaning and drying device for biological chip Download PDFInfo
- Publication number
- CN102814294A CN102814294A CN2012102038521A CN201210203852A CN102814294A CN 102814294 A CN102814294 A CN 102814294A CN 2012102038521 A CN2012102038521 A CN 2012102038521A CN 201210203852 A CN201210203852 A CN 201210203852A CN 102814294 A CN102814294 A CN 102814294A
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- drying device
- cleaning
- clearing
- cleaning box
- connecting plate
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- 238000004140 cleaning Methods 0.000 title claims abstract description 50
- 238000001035 drying Methods 0.000 title claims abstract description 22
- 238000000018 DNA microarray Methods 0.000 claims description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 14
- 239000012472 biological sample Substances 0.000 abstract description 3
- 239000007921 spray Substances 0.000 description 7
- 239000007788 liquid Substances 0.000 description 6
- 239000011159 matrix material Substances 0.000 description 5
- 238000007664 blowing Methods 0.000 description 4
- 238000011010 flushing procedure Methods 0.000 description 4
- 230000001105 regulatory effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 239000007789 gas Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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- Cleaning By Liquid Or Steam (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a cleaning and drying device for a biological chip. The cleaning and drying device comprises a cylinder, a clamping jaw and a cleaning box, wherein a first nozzle holder and a second nozzle holder are correspondingly arranged in front and back of the cleaning box; air nozzle holders are correspondingly arranged on the left and right in the cleaning box; the other end of each of shafts ,rotationally connected with the nozzle holders and the air nozzle holders, is in guide connection with a shaft connecting plate on the external end face of the cleaning box through long holes arranged on the cleaning box. According to the cleaning and drying device, the problems that the cleaning cannot be completely carried out, the cleaning pressure and the flow rate cannot be quantified, and the position cannot be adjusted can be solved, and meanwhile, thereby solving the problems that the biological samples arrayed on the surface of a chip are damaged or mutually polluted due to insufficient or excessive cleaning, and cannot be fully dried.
Description
Technical field
The present invention relates to a kind of clearing and drying device, relate in particular to a kind of clearing and drying device of biochip.
Background technology
Hard matrix chip is clamped to and cleans and the oven dry zone; Adopt circular staight needle pipe fixed position externally to spray liquid; Same fixed position firm discharge and the pressure of adopting externally sprays gas; Chip is driven by clamping device and moves up and down, and the injection of liquids and gases only is directed against the obverse and reverse of hard matrix chip.The distance of hydro-peening and air blowing, pressure, flow, angle can't be adjusted and control, and cause cleaning deficiency or overclean, and the biological sample of chip surface array is destroyed or pollutes each other, and the side can't dry up, and the liquid residue chip has a strong impact on next step technology.
Summary of the invention
The present invention seeks to provide a kind of clearing and drying device of biochip to the defective that prior art exists.
The present invention adopts following technical scheme for realizing above-mentioned purpose:
A kind of clearing and drying device of biochip; Comprise cylinder, jaw, cleaning box; Correspondence is provided with first, second nozzle carrier before and after in the said cleaning box; Correspondence is provided with the air nozzle seat about in the cleaning box, is connected with the axle connecting plate guiding of cleaning box outer face through the slotted hole that said cleaning box is provided with the axle other end that said nozzle carrier, air nozzle seat are rotationally connected.
Said water spout seat, air nozzle seat and axle connecting plate are provided with the fastening bolt that can be connected on the said axle.
Said axle connecting plate and said axle are connected for nonrotational mode.
Said axle connecting plate be provided with a plurality of can about the hex bolts of adjustment axle connecting plate relative position.
The chip cleaning needle that the bottom water spout seat of said first nozzle carrier is provided with the array pin hole and matches with said pin hole, said cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.
The side of said cleaning box is provided with horizontal pressing plate.
Said cleaning box bottom is provided with tap, and said tap is through the effluent discharge of sewer pipe joint.
The nozzle width of said air nozzle seat is slightly larger than the chip width.
The nozzle slit of said air nozzle seat is 0.3-0.4mm, width 5-6mm.
The present invention has following beneficial effect: solved the flushing unclean; Flushing pressure, the problem that flow can't quantize and the position can't be adjusted; Solved cleaning deficiency or overclean simultaneously, the biological sample of chip surface array is destroyed or pollutes each other, fully the problem of drying; 4 very thin air nozzles, at 4 faces, two positive and negatives facing to hard matrix chip; Two two sides facing to hard matrix chip, each nozzle can the implementation space the three-dimensional adjustment (X to, Y to; Anglec of rotation *); Add chip itself and moved up and down, constituted the comprehensive adjustment of 4 dimensions, realize the comprehensive covering of blowing chip by mechanisms grip.
Tow sides at chip are provided with fluid injector, and the front is 7 nozzle needles, and reverse side is 1 nozzle needle.Nozzle needle can be realized the adjustment of 3 dimensions equally, adds chip itself and is moved up and down by mechanisms grip, has constituted the comprehensive adjustment of 4 dimensions, realizes that the comprehensive cleaning that liquid sprays chip covers.
Positive jet and fluid injector structurally is designed to integral type, and the jet and fluid injector of reverse side structurally also is designed to integral type.
To chip, according to predetermined imagination, carry out jet cleaning earlier, dry up then; Also can dry up continued and clean, and then dry up.
The liquid jet cleaning time can be controlled separately, and the time that dries up also can be controlled separately, and the pressure of liquid and flow can be regulated separately; The jet time can be controlled separately, and pressure and flow also can be regulated separately.
Description of drawings
Fig. 1: structure principle chart of the present invention.
The B-B profile of Fig. 2: Fig. 1.
The partial enlarged drawing of Fig. 3: Fig. 2.
The A-A profile of Fig. 4: Fig. 1.
Fig. 5: the partial enlarged drawing of Fig. 4 II.
Fig. 6: general assembly axonometric drawing of the present invention.
The specific embodiment
Shown in Fig. 1-6; The present invention is a kind of clearing and drying device of biochip; Comprise cylinder 1, jaw 2, cleaning box 4; Correspondences are provided with first, second nozzle carrier 5,8 before and after in the said cleaning box 4, in the cleaning box 4 about correspondence air nozzle seat 7 is set, leading with the axle connecting plate 13 of cleaning box 4 outer faces with slotted hole that axle 6 other ends that said nozzle carrier 5,8, air nozzle seat 7 are rotationally connected are provided with through said cleaning box 4 is connected.Said water spout seat, air nozzle seat 7 and axle connecting plate 13 are provided with the fastening bolt 16 that can be connected on the said axle.Said axle connecting plate 13 is connected for nonrotational mode with said 6.Preferably, use square hole to cooperate guiding with square shaft usually.Said axle connecting plate 13 be provided with a plurality of can about the hex bolts 15 of adjustment axle connecting plate 13 relative positions.The chip cleaning needle 14 that the bottom water spout seat of said first nozzle carrier 5 is provided with the array pin hole and matches with said pin hole, said cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.The side of said cleaning box 4 is provided with horizontal pressing plate 9.Said cleaning box 4 bottoms are provided with tap, and said tap is through 10 effluent discharges of sewer pipe joint.The nozzle width of said air nozzle seat 7 is slightly larger than the chip width.The nozzle slit of said air nozzle seat 7 is 0.3-0.4mm, width 5-6mm.
The anterior water spout seat of the first water spout seat 5 is provided with the array pin hole, and the bottom water spout seat of the first water spout seat 5 is provided with 7 chip cleaning needles, and water spout seat 8 is designed to 1 cleaning needle 14, said pin hole internal diameter 0.2 mm external diameter 0.6mm.
The present invention has the tow sides water spray altogether, the positive and negative two sides that add, and the four sides is jet; Double-edged water spray and jet the design respectively on same carrier.
Glass matrix biochip 3 single face lattice array bioproteins, the surface sealing, after bioprotein chip and the seroreaction, need be from the cleaning and the drying of dividing, to carry out next step technology.
Clean
Adopt 4+3 array pin hole, the aperture of 0.2---0.6mm, positive seven, one of reverse side, the front is used for washing the front of the bioprotein of biochip, the reverse side of a pin flushing of reverse side chip.
The width range of flushing covers the width of chip, and 4+3 array pin hole staggers up and down all and distribution, to reach all the purpose with cleaning.
It is stainless steel that cleaning needle is installed carrier; Lateral inflow, water spray pressure and time can be regulated, and the carrier tilt adjustable is installed puts in order; Two dimensions in horizontal plane can be adjusted; The chip of band handle can combine above adjustment mode to be implemented in the adjustment on the four dimensions, to reach the effect of abundant cleaning when manually or automatically moving up and down.
Dry
Clean after the end, adopt medical purifying air to dry up chip.
Adopt stainless steel to be processed into spray nozzle of atmospheric pressure, nozzle width is slightly larger than the chip width, and jet slit is 0.3-0.4mm; The thin mouth type of protrusion is to save the space; But valve both direction is in the plane regulated, anglec of rotation scalable, and chip is when manually or automatically moving up and down; Can realize 4 position adjustment on the dimension, comprehensively dry up effect to reach.Chip all is provided with air nozzle at 4 faces, and each valve all has same adjustable function, and air blowing flow, pressure and time can be controlled separately through external equipment.
Blow and dry, efficiently solve the chip surface residual moisture, the problem of handle and chip residual moisture.
Double-edged nozzle of chip of the present invention and the jet integral type that is designed to, the blowing nozzle of side designs separately.
The above is merely preferred embodiment of the present invention, and is in order to restriction the present invention, not all within spirit of the present invention and principle, any modification of being done, is equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (10)
1. the clearing and drying device of a biochip; Comprise cylinder, jaw, cleaning box; It is characterized in that; Correspondence is provided with first, second nozzle carrier before and after in the said cleaning box, and correspondence was provided with the air nozzle seat about cleaning box was interior, is connected with the axle connecting plate guiding of cleaning box outer face through the slotted hole that said cleaning box is provided with the axle other end that said nozzle carrier, air nozzle seat are rotationally connected.
2. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, said water spout seat, air nozzle seat and axle connecting plate are provided with the fastening bolt that can be connected on the said axle.
3. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, said axle connecting plate and said axle are connected for nonrotational mode.
4. according to the clearing and drying device of claim 1 or 2 or 3 described a kind of biochips, it is characterized in that said axle connecting plate and said axle are connected for square hole and square shaft.
5. the clearing and drying device of a kind of biochip according to claim 4 is characterized in that, said axle connecting plate be provided with a plurality of can about the hex bolts of adjustment axle connecting plate relative position.
6. the clearing and drying device of a kind of biochip according to claim 1; It is characterized in that; The chip cleaning needle that the bottom water spout seat of said first nozzle carrier is provided with the array pin hole and matches with said pin hole, said cleaning needle internal diameter 0.2 mm, external diameter 0.6mm.
7. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, the side of said cleaning box is provided with horizontal pressing plate.
8. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, said cleaning box bottom is provided with tap, and said tap is through the effluent discharge of sewer pipe joint.
9. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, the nozzle width of said air nozzle seat is slightly larger than the chip width.
10. the clearing and drying device of a kind of biochip according to claim 1 is characterized in that, the nozzle slit of said air nozzle seat is 0.3-0.4mm, width 5-6mm.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210203852.1A CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201210203852.1A CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102814294A true CN102814294A (en) | 2012-12-12 |
| CN102814294B CN102814294B (en) | 2015-02-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201210203852.1A Active CN102814294B (en) | 2012-06-19 | 2012-06-19 | Cleaning and drying device for biological chip |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105344639A (en) * | 2015-11-06 | 2016-02-24 | 江苏三联生物工程有限公司 | Biological chip washing mechanism |
| CN105372437A (en) * | 2015-11-25 | 2016-03-02 | 江苏三联生物工程有限公司 | Biochip detection machine with scrubbing function |
| CN105510608A (en) * | 2015-11-25 | 2016-04-20 | 江苏三联生物工程有限公司 | Automatic biochip reading equipment |
| CN106334685A (en) * | 2016-10-19 | 2017-01-18 | 湖州数康生物科技有限公司 | Automatic cleaning system for biological chips |
| DE102013204646B4 (en) * | 2013-03-15 | 2018-04-05 | Leica Biosystems Nussloch Gmbh | Device for processing histological samples |
| CN108646039A (en) * | 2018-07-03 | 2018-10-12 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument |
| CN108856108A (en) * | 2018-07-03 | 2018-11-23 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
| CN111649559A (en) * | 2020-05-29 | 2020-09-11 | 立讯智造(浙江)有限公司 | Drying equipment for electronic products and drying method thereof |
| CN113020088A (en) * | 2021-05-19 | 2021-06-25 | 捷仪科技(北京)有限公司 | Chip washing device |
| CN117732772A (en) * | 2023-12-27 | 2024-03-22 | 东台市强胜精密电子工程有限公司 | Electroplating piece washing device for electroplating processing |
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2012
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102013204646B4 (en) * | 2013-03-15 | 2018-04-05 | Leica Biosystems Nussloch Gmbh | Device for processing histological samples |
| CN105344639A (en) * | 2015-11-06 | 2016-02-24 | 江苏三联生物工程有限公司 | Biological chip washing mechanism |
| CN105372437A (en) * | 2015-11-25 | 2016-03-02 | 江苏三联生物工程有限公司 | Biochip detection machine with scrubbing function |
| CN105510608A (en) * | 2015-11-25 | 2016-04-20 | 江苏三联生物工程有限公司 | Automatic biochip reading equipment |
| CN106334685A (en) * | 2016-10-19 | 2017-01-18 | 湖州数康生物科技有限公司 | Automatic cleaning system for biological chips |
| CN108856108A (en) * | 2018-07-03 | 2018-11-23 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument chip cleans dry body |
| CN108646039A (en) * | 2018-07-03 | 2018-10-12 | 无锡国盛生物工程有限公司 | Full-automatic protein chip immunity analysis instrument |
| CN108646039B (en) * | 2018-07-03 | 2024-09-03 | 无锡国盛生物工程股份有限公司 | Full-automatic protein chip immunity analyzer |
| CN111649559A (en) * | 2020-05-29 | 2020-09-11 | 立讯智造(浙江)有限公司 | Drying equipment for electronic products and drying method thereof |
| CN111649559B (en) * | 2020-05-29 | 2022-06-14 | 立讯智造(浙江)有限公司 | Drying equipment and drying method for electronic product |
| CN113020088A (en) * | 2021-05-19 | 2021-06-25 | 捷仪科技(北京)有限公司 | Chip washing device |
| CN113020088B (en) * | 2021-05-19 | 2021-08-10 | 捷仪科技(北京)有限公司 | Chip washing device |
| CN117732772A (en) * | 2023-12-27 | 2024-03-22 | 东台市强胜精密电子工程有限公司 | Electroplating piece washing device for electroplating processing |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102814294B (en) | 2015-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Cleaning and drying device for biological chip Effective date of registration: 20190726 Granted publication date: 20150218 Pledgee: Agricultural Bank of China Limited by Share Ltd Wuxi science and Technology Branch Pledgor: Jiangsu Sanlian Bioengineering Co., Ltd. Registration number: 2019990000792 |
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| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PC01 | Cancellation of the registration of the contract for pledge of patent right |
Date of cancellation: 20200810 Granted publication date: 20150218 Pledgee: Agricultural Bank of China Limited by Share Ltd. Wuxi science and Technology Branch Pledgor: SUNLANT BIOLOGICAL ENGINEERING Co.,Ltd. Registration number: 2019990000792 |
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| PC01 | Cancellation of the registration of the contract for pledge of patent right | ||
| CP03 | Change of name, title or address |
Address after: No. 35-305, Changjiang South Road, Xinwu District, Wuxi, Jiangsu 214111 Patentee after: Jiangsu Sanlian Bioengineering Co.,Ltd. Address before: 214038 block a, Xingye building, No. 97, Linghu Avenue, New District, Wuxi City, Jiangsu Province Patentee before: SUNLANT BIOLOGICAL ENGINEERING CO.,LTD. |
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| CP03 | Change of name, title or address |