CN102814155B - Have formerly purify and rinsing step for encapsulating NO/N2the method of mixture - Google Patents
Have formerly purify and rinsing step for encapsulating NO/N2the method of mixture Download PDFInfo
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- CN102814155B CN102814155B CN201210188886.8A CN201210188886A CN102814155B CN 102814155 B CN102814155 B CN 102814155B CN 201210188886 A CN201210188886 A CN 201210188886A CN 102814155 B CN102814155 B CN 102814155B
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- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 238000000034 method Methods 0.000 title claims abstract description 49
- 239000007789 gas Substances 0.000 claims abstract description 34
- 230000029142 excretion Effects 0.000 claims abstract description 11
- 239000012080 ambient air Substances 0.000 claims abstract description 9
- 239000012530 fluid Substances 0.000 claims abstract description 8
- 239000011261 inert gas Substances 0.000 claims abstract description 8
- 238000004891 communication Methods 0.000 claims abstract description 7
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 53
- 229910052757 nitrogen Inorganic materials 0.000 claims description 26
- 238000011010 flushing procedure Methods 0.000 claims description 4
- 239000008246 gaseous mixture Substances 0.000 claims description 3
- 238000000746 purification Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 2
- 239000003570 air Substances 0.000 description 7
- 239000012535 impurity Substances 0.000 description 6
- 238000005538 encapsulation Methods 0.000 description 5
- 210000000635 valve cell Anatomy 0.000 description 5
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000001301 oxygen Substances 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000002808 molecular sieve Substances 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 229910000838 Al alloy Inorganic materials 0.000 description 1
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 208000004248 Familial Primary Pulmonary Hypertension Diseases 0.000 description 1
- 206010064911 Pulmonary arterial hypertension Diseases 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XKMRRTOUMJRJIA-UHFFFAOYSA-N ammonia nh3 Chemical compound N.N XKMRRTOUMJRJIA-UHFFFAOYSA-N 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- TWNQGVIAIRXVLR-UHFFFAOYSA-N oxo(oxoalumanyloxy)alumane Chemical compound O=[Al]O[Al]=O TWNQGVIAIRXVLR-UHFFFAOYSA-N 0.000 description 1
- 201000008312 primary pulmonary hypertension Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C5/00—Methods or apparatus for filling containers with liquefied, solidified, or compressed gases under pressures
- F17C5/002—Automated filling apparatus
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2201/00—Vessel construction, in particular geometry, arrangement or size
- F17C2201/05—Size
- F17C2201/056—Small (<1 m3)
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2201/00—Vessel construction, in particular geometry, arrangement or size
- F17C2201/05—Size
- F17C2201/058—Size portable (<30 l)
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2203/00—Vessel construction, in particular walls or details thereof
- F17C2203/06—Materials for walls or layers thereof; Properties or structures of walls or their materials
- F17C2203/0634—Materials for walls or layers thereof
- F17C2203/0636—Metals
- F17C2203/0639—Steels
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2221/00—Handled fluid, in particular type of fluid
- F17C2221/01—Pure fluids
- F17C2221/014—Nitrogen
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2223/00—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel
- F17C2223/01—Handled fluid before transfer, i.e. state of fluid when stored in the vessel or before transfer from the vessel characterised by the phase
- F17C2223/0146—Two-phase
- F17C2223/0153—Liquefied gas, e.g. LPG, GPL
- F17C2223/0161—Liquefied gas, e.g. LPG, GPL cryogenic, e.g. LNG, GNL, PLNG
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2225/00—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel
- F17C2225/01—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel characterised by the phase
- F17C2225/0107—Single phase
- F17C2225/0123—Single phase gaseous, e.g. CNG, GNC
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2225/00—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel
- F17C2225/03—Handled fluid after transfer, i.e. state of fluid after transfer from the vessel characterised by the pressure level
- F17C2225/036—Very high pressure, i.e. above 80 bars
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/01—Propulsion of the fluid
- F17C2227/0128—Propulsion of the fluid with pumps or compressors
- F17C2227/0135—Pumps
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/03—Heat exchange with the fluid
- F17C2227/0302—Heat exchange with the fluid by heating
- F17C2227/0309—Heat exchange with the fluid by heating using another fluid
- F17C2227/0311—Air heating
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2227/00—Transfer of fluids, i.e. method or means for transferring the fluid; Heat exchange with the fluid
- F17C2227/04—Methods for emptying or filling
- F17C2227/044—Methods for emptying or filling by purging
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2265/00—Effects achieved by gas storage or gas handling
- F17C2265/01—Purifying the fluid
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- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2270/00—Applications
- F17C2270/02—Applications for medical applications
- F17C2270/025—Breathing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F17—STORING OR DISTRIBUTING GASES OR LIQUIDS
- F17C—VESSELS FOR CONTAINING OR STORING COMPRESSED, LIQUEFIED OR SOLIDIFIED GASES; FIXED-CAPACITY GAS-HOLDERS; FILLING VESSELS WITH, OR DISCHARGING FROM VESSELS, COMPRESSED, LIQUEFIED, OR SOLIDIFIED GASES
- F17C2270/00—Applications
- F17C2270/05—Applications for industrial use
- F17C2270/059—Mass bottling, e.g. merry belts
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- General Engineering & Computer Science (AREA)
- Vacuum Packaging (AREA)
- Filling Or Discharging Of Gas Storage Vessels (AREA)
- Processing And Handling Of Plastics And Other Materials For Molding In General (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
Abstract
The present invention relates to a kind of for by gaseous state NO/N2Mixture is encapsulated in the method at least one container, it is characterised in that allowing described NO/N2Before mixture enters, at least one container described at least experiences purifying step, excretion step and gas rinsing step, during described purifying step, the internal capacity of container is placed in and is in fluid communication with ambient air, during described excretion step, the internal capacity of container is placed under low pressure, during described gas bleed step, it is allowed to inert gas enters at least one container described.For preferably, final gaseous state NO/N2Mixture comprises less than or equal to 1200ppm(volume under the pressure between P1 and 800 bars) NO content.
Description
Technical field
The present invention relates to a kind of for by gaseous state NO/N2Mixture is encapsulated in the method in the most one or more cylinder of container, and described method includes various purification in succession and gas rinsing step.
Background technology
Gaseous state NO/N2Mixture be generally used for treatment adult or children especially infect primary pulmonary hypertension neonate or accepted openheart surgery patient Pulmonary Vascular shrink.
These NO/N2Mixture is normally encapsulated in steel cylinder/gas cylinder.Generally, these cylinders/bottle accommodate from 100 to 1000ppm(volume) NO, remaining is nitrogen (N2).These cylinders are generally of the water capacity of 2 to 50 liters, it means that these cylinders can accommodate total charging quantity up to 15m3NO/N2Mixture.
The encapsulation of these mixtures, in other words to these mixtures of cylinder filling, completes at gas filling center.
But, if the NO content in mixture is low, it is typically hundreds of ppm(volume) the order of magnitude, then and be not always prone to encapsulate these mixtures on an industrial scale.Especially, gaseous state NO/N2Mixture is sensitive to the existence of oxygen type residual impurity, and described impurity is prone to when cylinder filling exist in cylinder.
It practice, the most important thing is to be able to ensure that cylinder is correctly removed all gaseous impurities that they are prone to comprise before being filled with, especially can react with NO and form toxicity NO2Oxygen.
In other words, if the internal capacity of cylinder is not correctly purified and is cleaned, then produced NO/N2Mixture will fall short of specifications and will go out of use.
Therefore, haveing a problem in that the method for packing providing a kind of improvement, this method for packing allows to eliminate impurity described in impurity especially oxygen all or almost all and is prone at NO/N to be received2Exist in one or more cylinders of type gaseous mixture.
Summary of the invention
Therefore, the solution of the present invention is a kind of for by gaseous state NO/N2Mixture is encapsulated in the method in the most one or more cylinder of at least one container, it is characterised in that accepting described NO/N2Before mixture, at least one container described, in other words the one or more container, at least experience following steps:
A) purify (purging cleans) step, during described purifying step, the internal capacity of described container be placed in and be in fluid communication with ambient air,
B) excretion (evacuating, evacuate) step, during described excretion step, the internal capacity of described container is placed under low pressure, reduce the internal pressure of described container in other words until the internal pressure of described container reaches subatmospheric pressure (＜ 1 bar absolute value), and
C) gas bleed step, during described gas bleed step, it is allowed to inert gas enters at least one container described.
Playing by ear, it is one or more that the method for the present invention can have in techniques below feature:
-by using vavuum pump gas bleeding to perform to drain step b).
-at least one container described is at described NO/N2Mixture experiences step a) and step c) several times in succession before being allowed to enter at least one container described.
-two in succession include that step a) and sequence c) are included step a), sequence separates b) and c) by one.
Including after step a), sequence b) and c) and then one include step a) and sequence c) or one include step a), sequence c) and a).
-during step c), the described inert gas being used for performing described gas bleed is nitrogen.
-several gas containers experience step a) to c) simultaneously.
-after executed at least two includes step a) and sequence c), it is allowed to by NO and N2The gaseous mixture of composition enters the one or more container.
-after executed at least two includes step a) and sequence c), it is allowed to following (gas) subsequently enters the one or more container:
I) comprise less than 10%(volume) NO content by NO and N2The gaseous state pre-composition of composition, until reaching the first pressure P1, wherein P1 ＞ 1 bar absolute value；
Ii) gaseous nitrogen, until by described nitrogen and described NO/N2The mixing of pre-composition and realize comprising less than or equal to 1200ppm(volume) NO content and the final gaseous state NO/N of the second pressure P2 between P1 and 800 bars2Mixture.
-gas bleed step c) includes allowing gaseous nitrogen to enter the one or more container, until the flushing pressure reaching between 2 bars and 20 bars, being preferably ranges between 2 bars and 12 bars in the one or more container.
-in purifying step a) period, keep internal capacity and the atmosphere of described container, as long as the internal pressure within described container is higher than minimum purification pressure (Pmin), 3.5 bar ＞ Pmin ＞ 1 bars, preferably Pmin is between about 1.1 bars and 3 bars.
-during at least one excretion step b), the internal capacity of described container is placed under low pressure, until reaching less than 0.5 bar, the stress level that is preferably lower than 0.2 bar.
-described method be included in step a) before excretion step d) and purify the step e) of at least flexible hose that described filling system is connected to gas container.
-during described gas bleed step c), when the pressure at least one container described reach between 2 bars and 20 bars, the value that is preferably ranges between 3 bars and 10 bars time, stop allowing inert gas to enter at least one container described.
-when the pressure in the internal capacity of described container reaches the value between 1 bar and 1.5 bars, stop at the fluid communication of purifying step a) period and ambient air.
-the first pressure P1 between 2 bars and 10 bars, preferably less or equal to 5 bars.
-the second pressure, between 100 bars and 700 bars, is preferably at least 200 bars.
-by NO and N2Composition gaseous state pre-composition comprise less than or equal to 8%(volume) NO content, preferably less or equal to 5%(volume) NO content.
-by NO and N2To comprise the order of magnitude be 4%(volume to the gaseous state pre-composition of composition) NO content and the order of magnitude of described first pressure P1 be 2 to 10 bar absolute values, the such as order of magnitude be 2 to 5 bar absolute values.
-described final gaseous state NO/N2Mixture comprises less than or equal to 1000ppm(volume) NO content, the most described final gaseous state NO/N2Mixture comprises between 200ppm and 1000ppm(volume) between and more preferably between 200ppm and 800ppm(volume) between NO content.
-described method uses the gas container filling system including allowing the attachment means of the several container of one-time filling to perform.
-described container is cylinder, it is therefore preferable to have the cylinder of the body being made up of steel, aluminum or aluminum alloy.
In the context of the present invention, cited pressure is absolute pressure.
Accompanying drawing explanation
It is more fully understood that the present invention by means of description given below, in the accompanying drawings now with reference to accompanying drawing:
-Fig. 1 schematically shows an embodiment of the encapsulation circulation according to the present invention, and
-Fig. 2 is performed for the figure of the equipment of the method for the present invention.
Detailed description of the invention
Fig. 1 schematically shows the encapsulation gaseous state NO/N that can apply to the present invention2One embodiment of the encapsulation circulation in the context of the method for mixture.
As can be seen, this encapsulation circulation includes several sequential step, and these steps were spaced apart on the time from T0 to T13, and is applicable to each cylinder and described below.The sequential step a) of the method for the present invention is to c) figure 1 illustrates.
Between T0 and T1, make the flexible hose of equipment communicate with extraneous air, the internal capacity of flexible filling flexible pipe is placed in is in fluid communication with ambient air in other words, in order to remove any possible residual unlifting pressure.During this stage, one or more valves of the gas container being connected to flexible pipe cut out, so that not existing and the gas exchanges of one or more containers.This is corresponding to the step d) of described method.
Between T1 and T2, using vavuum pump to be internally located at by flexible hose under the low pressure of connection, the most subatmospheric pressure, the such as order of magnitude are 0.15 bar, so that remove any residual gas and/or air wherein comprised.Therefore, this stage also performs in the case of cylinder valve is closed.Flexible hose is placed under vacuum and is so that and can check that all flexible pipes the most correctly connect and whether there is the safety measure of leakage.Specifically, if be connected improperly if there is leakage or flexible pipe, then will be unable to form stable vacuum.The step e) of this method corresponding to schematically showing in Fig. 1.
Between T2 and T3, the residual pressure that operating personnel exist in opening the valve on each cylinder and each cylinder rises subsequently and arrives this pressure sensor of pressure sensor and detects that described pressure rises.Typically, in cylinder, residual pressure has the order of magnitude of about 3 to 4 bar absolute values.Before T2, with nitrogen, container is not carried out gas bleed.The step f) of this method corresponding to schematically showing in Fig. 1.
Between T3 and T4, start the actual treatment of each cylinder.More specifically, each cylinder all communicates with air, i.e. allow the gas being accommodated in cylinder in cylinder and cylinder outer between pressure differential simple effect under loss to outside atmosphere, in order to make the internal pressure of cylinder be reduced to atmospheric pressure.This is corresponding to the step a) of the method for the present invention.At T4, the internal pressure of cylinder is the most more or less equal to atmospheric pressure (1atm=about 1 bar absolute value), i.e. the order of magnitude is 1 to 1.5 bar absolute value.
Between T4 and T5, being purged with nitrogen cylinder, the internal pressure of cylinder rises to about 10 bars simultaneously.Pressurize via gas piping and/or nitrogen to lay in and perform the interpolation of nitrogen to make the internal pressure of cylinder rise to desirable pressure.This is corresponding to the step c) of the method for the present invention.
Between T5 and T6, again allowing the nitrogen loss being accommodated in cylinder to air, in this allows cylinder, any impurity that may be present is removed.This is corresponding to the another step a) of the method for the present invention.
Between T6 and T7, by the internal capacity of cylinder being placed in low pressure get off to purify cylinder via using vavuum pump to extract the residual gas that is accommodated in cylinder out, until be less than 0.2 bar absolute value, preferably less than 0.1 bar, the such as order of magnitude is the internal low-voltage of 0.05 bar.This is corresponding to the another step b) of the method for the present invention.
Between T7 and T8, nitrogen is used cylinder to be rinsed, so that its internal pressure rises to about 10 bars as between T4 and T5 again.This is corresponding to the another step c) of the method for the present invention.
Between T8 and T9, cylinder is again made to communicate with ambient air as between time T5 with T6.Residual gas pressure is then retained in about 1.35 bars, to avoid undesirable atmosphere pollution to enter.This is corresponding to the another step a) of the method for the present invention.
Between T9 and T10, nitrogen is used again cylinder to be carried out other flushing, so that its internal pressure rises to about 10 bars as before.This is corresponding to the another step c) of the method for the present invention.
Between T10 and T11, by nitrogen discharge to air, as between T8 and T9 and between T5 and T6, but the residual internal pressure maintaining the order of magnitude to be 3 bars specifically.This is corresponding to the another step a) of the method for the present invention.
Between T11 and T12, it is allowed to comprise less than 10%(volume) NO content by NO and N2The gaseous state pre-composition of composition enters cylinder, in order to reaching the first stowing pressure P1, wherein P1 ＞ 1 bar, the typically order of magnitude of pressure P1 is 2 to 10 bar absolute values, preferably about 3 to 5 bar absolute values.Advantageously, by NO and N2To comprise the order of magnitude be 4%(volume to the gaseous state pre-composition of composition) NO content.
Between T12 and T13, then allow for gaseous nitrogen entrance and comprise the NO/N being in the first pressure P12The container of pre-composition, in order to obtain and comprise less than or equal to 1200ppm(volume) the final NO content of NO content such as 200 to 800ppm and the pressure P2 between P1 and 800 bars be the gaseous state NO/N of pressure of 180 to 200 bars the most in this example embodiment2Mixture.
The method can perform via the sealed in unit schematically shown in such as Fig. 2, described sealed in unit is equipped with the filling system 14 for the i.e. cylinder of filling gas container, and this filling system 14 includes that allowing disposably to connect several container 11-13 typically allows to be simultaneously connected with the attachment means 15 of 2 to 20 cylinders.
Nitrogen is stored in reservoir 1 in liquid form, is then extracted out in liquid form by cryogenic pump 2, and nitrogen is compressed to the pressure that the order of magnitude is 100 to 300 bars before producing gaseous nitrogen nitrogen is transported to the evaporation of big hot-air heater 3 wherein nitrogen by described cryogenic pump 2.As can be seen, this equipment includes main line or the pipeline 20 for nitrogen is transported to filling system 14 from reservoir 1.It is true that the pressure of pipeline changes between about 260 bars that about 100 bars in downstream immediately flowing out stream flowed to from buffer volume in cylinder and threshold value out-of-work with pump are corresponding.
Then nitrogen be transported to purifier 6 by pipeline 20, and this purifier 6 can such as use the molecular sieve of suitable molecular sieve such as zeolite, Silica hydrogel, aluminum oxide or similar type or its mixture to remove eliminating minute O2And H2O。
It should be noted that pipeline 20 also fluidly connects with buffer volume 4 and standby support (backup rack) 5, described buffer volume 4 can store some gaseous nitrogens, and described standby support 5 all includes several nitrogen cylinder.
Additionally, this equipment also includes that frame case 16, described frame case include several NO/N2The NO of pre-composition (comprising 4%(volume at this)) cylinder 9, described cylinder 9 passes through NO/N2Pre-composition feeding pipe 22 fluidly connects with pipeline 20.It is true that NO/N2Pipeline 22 and nitrogen pipeline 20 are not connected directly to each other, but are connected with valve cell 8, and described valve cell 8 is connected with one or more filling systems 14 itself by pipeline 21.Valve in valve cell 8 allows to the fluid selected in the cylinder 11 to 13 of the system that is filled to 14.Therefore, nitrogen pipeline 20 and NO/N2Pre-composition pipeline 22 is first passed through valve cell 8 and is then fluidly connected with filling system 14 by common section 21.Valve cell 8 includes valve, by controlling the control element etc. that device 10 controls.
Flowmeter 7 allows to measure the N flowing through pipeline 20 and 222With the amount of NO mensuration information is transferred to such as computer equal controller 10.
Described equipment also includes the pipeline 17 communicated with air, and this pipeline 17 allows gas is discharged into ambient air, especially purifying step or the internal capacity of container is placed in ambient air fluid communication step during.
Vavuum pump (not shown) allows to drain one or more containers, i.e. allows the internal pressure of container to be decreased below the pressure of atmospheric pressure, i.e. ＜ 1 bar absolute value.
Claims (21)
1. one kind is used for gaseous state NO/N2Mixture is encapsulated in the method at least one container, it is characterised in that allowing described NO/N2Before mixture enters, at least one container described at least experiences:
A) purifying step, during described purifying step, is placed in the internal capacity of described container and is in fluid communication with ambient air,
B) excretion step, during described excretion step, is placed in the internal capacity of described container under low pressure, and
C) gas bleed step, during described gas bleed step, it is allowed to inert gas enters at least one container described.
Method the most according to claim 1, it is characterised in that at least one container described is at described NO/N2Mixture experiences step a) and step c) several times before being allowed to enter at least one container described in succession.
Method the most according to claim 2, it is characterised in that two in succession include that step a) and sequence c) are by including step a), sequence separates b) and c).
4. according to the method described in claim 1 or 3, it is characterised in that and then include step a) and sequence c) after including step a), sequence b) and c) or include step a), sequence c) and a).
5. according to the method according to any one of claim 1-3, it is characterised in that in step c) period, the described inert gas being used for performing described gas bleed is nitrogen.
6. according to the method according to any one of claim 1-3, it is characterised in that several gas containers experience step a) to c) simultaneously.
The most according to the method in claim 2 or 3, it is characterised in that after executed at least two includes step a) and sequence c), it is allowed to by NO and N2The gaseous mixture of composition enters one or more described containers.
The most according to the method in claim 2 or 3, it is characterised in that after executed at least two includes step a) and sequence c), the one or more described containers of following entrance are in succession allowed:
I) comprise the NO content less than 10% (volume) by NO and N2The gaseous state pre-composition of composition, until reaching the first pressure P1, wherein P1 ＞ 1 bar absolute value；
Ii) gaseous nitrogen, until by described nitrogen and described NO/N2The mixing of pre-composition and realize comprising the NO content less than or equal to 1200ppm (volume) and the final gaseous state NO/N of the second pressure P2 between P1 and 800 bars2Mixture.
9. according to the method according to any one of claim 1-3, it is characterized in that, described gas bleed step c) includes allowing gaseous nitrogen to enter one or more described containers, until reaching the flushing pressure between 2 bars and 20 bars in one or more described containers.
10. according to the method according to any one of claim 1-3, it is characterized in that, in described purifying step a) period, keep internal capacity and the atmosphere of described container, as long as the internal pressure within described container is higher than minimum purification pressure Pmin, 3.5 bar ＞ Pmin ＞ 1 bars.
11. according to the method according to any one of claim 1-3, it is characterised in that at least one excretion step b) period, be placed under low pressure by the internal capacity of described container, until reaching the stress level less than 0.5 bar.
12. according to the method according to any one of claim 1-3, it is characterised in that described method be included in step a) before excretion step d) and purify the step e) of at least flexible hose that filling system is connected to gas container.
13. according to the method according to any one of claim 1-3, it is characterised in that described final gaseous state NO/N2Mixture comprises the NO content less than or equal to 1000ppm (volume).
14. according to the method according to any one of claim 1-3, it is characterized in that, in described gas bleed step c) period, when the pressure at least one container described reaches the value between 2 bars and 20 bars, stop allowing inert gas to enter at least one container described.
15. according to the method according to any one of claim 1-3, it is characterised in that when the pressure in the internal capacity of described container reaches the value between 1 bar and 1.5 bars, stops at the fluid communication of purifying step a) period and ambient air.
16. methods according to claim 9, it is characterised in that described gas bleed step c) includes allowing gaseous nitrogen to enter one or more described containers, until reaching the flushing pressure between 2 bars and 12 bars in one or more described containers.
17. methods according to claim 10, it is characterised in that Pmin is between 1.1 bars and 3 bars.
18. methods according to claim 11, it is characterised in that at least one excretion step b) period, the internal capacity of described container is placed under low pressure, until reaching the stress level less than 0.2 bar.
19. methods according to claim 13, it is characterised in that described final gaseous state NO/N2Mixture comprises between the NO content between 200ppm and 1000ppm (volume).
20. methods according to claim 13, it is characterised in that described final gaseous state NO/N2Mixture comprises between the NO content between 200ppm and 800ppm (volume).
21. methods according to claim 14, it is characterised in that in described gas bleed step c) period, when the pressure at least one container described reaches the value between 3 bars and 10 bars, stop allowing inert gas to enter at least one container described.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1155038 | 2011-06-09 | ||
| FR1155038A FR2976260B1 (en) | 2011-06-09 | 2011-06-09 | PROCESS FOR PACKAGING NO / N2 MIXTURES WITH PURGE STAGES AND PRIOR GAS RINSING |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102814155A CN102814155A (en) | 2012-12-12 |
| CN102814155B true CN102814155B (en) | 2016-09-07 |
Family
ID=45998206
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201210188886.8A Active CN102814155B (en) | 2011-06-09 | 2012-06-08 | Have formerly purify and rinsing step for encapsulating NO/N2the method of mixture |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120312416A1 (en) |
| EP (1) | EP2532941B2 (en) |
| CN (1) | CN102814155B (en) |
| BR (1) | BR102012013702B8 (en) |
| ES (1) | ES2501090T5 (en) |
| FR (1) | FR2976260B1 (en) |
| ZA (1) | ZA201203663B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2976259B1 (en) * | 2011-06-09 | 2013-07-05 | Air Liquide | PROCESS FOR CONDITIONING A NO / N2 GAS MIXTURE |
| FR2976258B1 (en) * | 2011-06-09 | 2014-09-05 | Air Liquide | INSTALLATION OF PACKAGING OF NO TO MASS FLOWMETERS |
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| US5826632A (en) * | 1997-05-30 | 1998-10-27 | The Boc Group, Inc. | Dynamic gas cylinder filling process |
| US6152192A (en) * | 1998-02-11 | 2000-11-28 | Welding Company Of America | Controller for system for filling gas cylinders with single gas or gas mixture |
| WO2008132402A1 (en) * | 2007-03-27 | 2008-11-06 | L'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Method and device for preparing pressurised gas cylinders |
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| DK0560928T3 (en) † | 1990-12-05 | 1997-12-01 | Gen Hospital Corp | Devices for the treatment of pulmonary vasoconstriction and asthma |
| US5540251A (en) * | 1994-02-01 | 1996-07-30 | Mayeaux; Paul H. | Precision gas blender |
| US5476115A (en) * | 1994-03-10 | 1995-12-19 | Praxair Technology, Inc. | Automatic gas blending system |
| US7334708B2 (en) * | 2001-07-16 | 2008-02-26 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Integral blocks, chemical delivery systems and methods for delivering an ultrapure chemical |
| US6655422B2 (en) † | 2001-09-26 | 2003-12-02 | Atnl, Inc. | Computer controlled apparatus and method of filling cylinders with gas |
| US20060060139A1 (en) * | 2004-04-12 | 2006-03-23 | Mks Instruments, Inc. | Precursor gas delivery with carrier gas mixing |
| US7328726B2 (en) * | 2006-01-20 | 2008-02-12 | Air Products And Chemicals, Inc. | Ramp rate blender |
| US7621302B2 (en) * | 2007-09-28 | 2009-11-24 | Airgas, Inc. | Coriolis dosing system for filling gas cylinders |
| CA2671029A1 (en) † | 2009-06-30 | 2010-12-30 | James S. Baldassarre | Methods of treating term and near-term neonates having hypoxic respiratory failure associated with clinical or echocardiographic evidence of pulmonary hypertension |
| FR2976259B1 (en) * | 2011-06-09 | 2013-07-05 | Air Liquide | PROCESS FOR CONDITIONING A NO / N2 GAS MIXTURE |
-
2011
- 2011-06-09 FR FR1155038A patent/FR2976260B1/en active Active
-
2012
- 2012-05-03 EP EP12166496.5A patent/EP2532941B2/en active Active
- 2012-05-03 ES ES12166496.5T patent/ES2501090T5/en active Active
- 2012-05-18 ZA ZA2012/03663A patent/ZA201203663B/en unknown
- 2012-05-24 US US13/480,289 patent/US20120312416A1/en not_active Abandoned
- 2012-06-06 BR BR102012013702A patent/BR102012013702B8/en active IP Right Grant
- 2012-06-08 CN CN201210188886.8A patent/CN102814155B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5826632A (en) * | 1997-05-30 | 1998-10-27 | The Boc Group, Inc. | Dynamic gas cylinder filling process |
| CN1137767C (en) * | 1997-05-30 | 2004-02-11 | 波克股份有限公司 | Dynamic gas cylinder filling process |
| US6152192A (en) * | 1998-02-11 | 2000-11-28 | Welding Company Of America | Controller for system for filling gas cylinders with single gas or gas mixture |
| WO2008132402A1 (en) * | 2007-03-27 | 2008-11-06 | L'air Liquide Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude | Method and device for preparing pressurised gas cylinders |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2501090T3 (en) | 2014-10-01 |
| ES2501090T5 (en) | 2018-04-18 |
| EP2532941B2 (en) | 2018-02-28 |
| FR2976260A1 (en) | 2012-12-14 |
| FR2976260B1 (en) | 2013-07-05 |
| ZA201203663B (en) | 2013-01-30 |
| BR102012013702B1 (en) | 2022-04-26 |
| BR102012013702B8 (en) | 2022-05-24 |
| BR102012013702A2 (en) | 2013-07-30 |
| US20120312416A1 (en) | 2012-12-13 |
| CN102814155A (en) | 2012-12-12 |
| EP2532941B1 (en) | 2014-07-02 |
| EP2532941A1 (en) | 2012-12-12 |
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