CN102657703A - New application of traditional Chinese medicine buddleja officinalis - Google Patents
New application of traditional Chinese medicine buddleja officinalis Download PDFInfo
- Publication number
- CN102657703A CN102657703A CN2012101806872A CN201210180687A CN102657703A CN 102657703 A CN102657703 A CN 102657703A CN 2012101806872 A CN2012101806872 A CN 2012101806872A CN 201210180687 A CN201210180687 A CN 201210180687A CN 102657703 A CN102657703 A CN 102657703A
- Authority
- CN
- China
- Prior art keywords
- flos buddlejae
- purposes
- hair
- alopecia
- flos
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 43
- 241000123846 Buddleja officinalis Species 0.000 title abstract description 5
- 201000004384 Alopecia Diseases 0.000 claims abstract description 81
- 210000004209 hair Anatomy 0.000 claims abstract description 66
- 231100000360 alopecia Toxicity 0.000 claims abstract description 51
- 229940079593 drug Drugs 0.000 claims abstract description 16
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 241000628997 Flos Species 0.000 claims description 126
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 29
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 27
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 claims description 24
- 206010068168 androgenetic alopecia Diseases 0.000 claims description 18
- 201000002996 androgenic alopecia Diseases 0.000 claims description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 18
- 239000012567 medical material Substances 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- 239000000843 powder Substances 0.000 claims description 14
- 230000002265 prevention Effects 0.000 claims description 14
- 238000010438 heat treatment Methods 0.000 claims description 13
- 239000002775 capsule Substances 0.000 claims description 12
- 239000007788 liquid Substances 0.000 claims description 12
- 238000000605 extraction Methods 0.000 claims description 11
- 230000003676 hair loss Effects 0.000 claims description 11
- 208000002720 Malnutrition Diseases 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- 230000001071 malnutrition Effects 0.000 claims description 9
- 235000000824 malnutrition Nutrition 0.000 claims description 9
- 208000015380 nutritional deficiency disease Diseases 0.000 claims description 9
- 238000010992 reflux Methods 0.000 claims description 9
- 239000000203 mixture Substances 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 claims description 7
- 238000002481 ethanol extraction Methods 0.000 claims description 5
- 239000002024 ethyl acetate extract Substances 0.000 claims description 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 4
- 239000002021 butanolic extract Substances 0.000 claims description 3
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 21
- 235000015097 nutrients Nutrition 0.000 abstract description 7
- 230000001737 promoting effect Effects 0.000 abstract description 3
- 230000008719 thickening Effects 0.000 abstract 1
- 239000008280 blood Substances 0.000 description 25
- 210000004369 blood Anatomy 0.000 description 24
- 210000004761 scalp Anatomy 0.000 description 18
- SEBIKDIMAPSUBY-JAUCNNNOSA-N Crocin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C(=O)OC1OC(COC2OC(CO)C(O)C(O)C2O)C(O)C(O)C1O)C=CC=C(/C)C(=O)OC3OC(COC4OC(CO)C(O)C(O)C4O)C(O)C(O)C3O SEBIKDIMAPSUBY-JAUCNNNOSA-N 0.000 description 17
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 description 17
- 210000003780 hair follicle Anatomy 0.000 description 16
- 229930182470 glycoside Natural products 0.000 description 15
- 150000002338 glycosides Chemical class 0.000 description 13
- 230000028327 secretion Effects 0.000 description 13
- 235000001014 amino acid Nutrition 0.000 description 11
- 229940024606 amino acid Drugs 0.000 description 11
- 150000001413 amino acids Chemical class 0.000 description 11
- 239000003925 fat Substances 0.000 description 11
- 210000004185 liver Anatomy 0.000 description 11
- 238000002156 mixing Methods 0.000 description 11
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 230000003779 hair growth Effects 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 208000003251 Pruritus Diseases 0.000 description 7
- -1 antibacterial Substances 0.000 description 7
- 210000004204 blood vessel Anatomy 0.000 description 7
- 235000019439 ethyl acetate Nutrition 0.000 description 7
- 238000011160 research Methods 0.000 description 7
- DANYIYRPLHHOCZ-UHFFFAOYSA-N 5,7-dihydroxy-4'-methoxyflavone Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 DANYIYRPLHHOCZ-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 230000018109 developmental process Effects 0.000 description 6
- 239000011573 trace mineral Substances 0.000 description 6
- 235000013619 trace mineral Nutrition 0.000 description 6
- 229930003231 vitamin Natural products 0.000 description 6
- 235000013343 vitamin Nutrition 0.000 description 6
- 239000011782 vitamin Substances 0.000 description 6
- 229940088594 vitamin Drugs 0.000 description 6
- 150000003722 vitamin derivatives Chemical class 0.000 description 6
- 102000002045 Endothelin Human genes 0.000 description 5
- 108050009340 Endothelin Proteins 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- ZOLPMMWNCLHKPX-UHFFFAOYSA-N ligustrin Natural products CC1=CCC2C1C3OC(=C)C(=O)C3C(O)CC2=C ZOLPMMWNCLHKPX-UHFFFAOYSA-N 0.000 description 5
- 235000016709 nutrition Nutrition 0.000 description 5
- QJVXKWHHAMZTBY-GCPOEHJPSA-N syringin Chemical compound COC1=CC(\C=C\CO)=CC(OC)=C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 QJVXKWHHAMZTBY-GCPOEHJPSA-N 0.000 description 5
- 210000003556 vascular endothelial cell Anatomy 0.000 description 5
- 206010061218 Inflammation Diseases 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 230000000844 anti-bacterial effect Effects 0.000 description 4
- 230000003064 anti-oxidating effect Effects 0.000 description 4
- 230000003778 catagen phase Effects 0.000 description 4
- 235000009508 confectionery Nutrition 0.000 description 4
- 201000010099 disease Diseases 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 210000003725 endotheliocyte Anatomy 0.000 description 4
- 210000003038 endothelium Anatomy 0.000 description 4
- 239000000945 filler Substances 0.000 description 4
- 229930003944 flavone Natural products 0.000 description 4
- 235000011949 flavones Nutrition 0.000 description 4
- 210000001061 forehead Anatomy 0.000 description 4
- 210000003128 head Anatomy 0.000 description 4
- 230000004054 inflammatory process Effects 0.000 description 4
- 239000000314 lubricant Substances 0.000 description 4
- 230000035764 nutrition Effects 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 150000003254 radicals Chemical class 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 230000001225 therapeutic effect Effects 0.000 description 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- 108091006146 Channels Proteins 0.000 description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 3
- 229930003268 Vitamin C Natural products 0.000 description 3
- 235000009962 acacetin Nutrition 0.000 description 3
- 230000003035 anti-peroxidant effect Effects 0.000 description 3
- 230000002421 anti-septic effect Effects 0.000 description 3
- 239000012141 concentrate Substances 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 3
- 210000002889 endothelial cell Anatomy 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000009583 hair follicle growth Effects 0.000 description 3
- 230000036039 immunity Effects 0.000 description 3
- 150000002632 lipids Chemical class 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 210000000056 organ Anatomy 0.000 description 3
- 230000004792 oxidative damage Effects 0.000 description 3
- 230000035699 permeability Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000000284 resting effect Effects 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 235000017709 saponins Nutrition 0.000 description 3
- 210000001732 sebaceous gland Anatomy 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- 239000003381 stabilizer Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- KDSWDGKIENPKLB-QJDQKFITSA-N verbascoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1O[C@H]1[C@H](OC(=O)CCC=2C=C(O)C(O)=CC=2)[C@@H](CO)O[C@@H](OCCC=2C=C(O)C(O)=CC=2)[C@@H]1O KDSWDGKIENPKLB-QJDQKFITSA-N 0.000 description 3
- QFRYQWYZSQDFOS-UHFFFAOYSA-N verbascoside Natural products CC1OC(COC2C(O)C(COC3OC(C(O)C(O)C3O)C(=O)O)OC(Oc4cc(O)cc5OC(=CC(=O)c45)c6ccc(O)c(O)c6)C2O)C(O)C(O)C1O QFRYQWYZSQDFOS-UHFFFAOYSA-N 0.000 description 3
- 235000019154 vitamin C Nutrition 0.000 description 3
- 239000011718 vitamin C Substances 0.000 description 3
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-Phenylethanol Natural products OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 2
- YFVGIJBUXMQFOF-PJOVQGMDSA-N 5-hydroxy-2-(4-methoxyphenyl)-7-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-[[(2r,3r,4r,5r,6s)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one Chemical compound C1=CC(OC)=CC=C1C(OC1=C2)=CC(=O)C1=C(O)C=C2O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)O1 YFVGIJBUXMQFOF-PJOVQGMDSA-N 0.000 description 2
- MQBFFYQCZCKSBX-UHFFFAOYSA-N 5-hydroxy-6,7,8-trimethoxy-2-(3,4,5-trimethoxyphenyl)chromen-4-one Chemical compound COC1=C(OC)C(OC)=CC(C=2OC3=C(OC)C(OC)=C(OC)C(O)=C3C(=O)C=2)=C1 MQBFFYQCZCKSBX-UHFFFAOYSA-N 0.000 description 2
- 208000019901 Anxiety disease Diseases 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 206010020880 Hypertrophy Diseases 0.000 description 2
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 2
- YFVGIJBUXMQFOF-SAXLCNSLSA-N Linarin Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4ccc(OC)cc4)Oc3c2)O1)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 YFVGIJBUXMQFOF-SAXLCNSLSA-N 0.000 description 2
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 2
- 239000004472 Lysine Substances 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000475481 Nebula Species 0.000 description 2
- 206010037601 Pyelonephritis chronic Diseases 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 2
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 description 2
- 239000004473 Threonine Substances 0.000 description 2
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000003098 androgen Substances 0.000 description 2
- 102000001307 androgen receptors Human genes 0.000 description 2
- 108010080146 androgen receptors Proteins 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 2
- 235000008714 apigenin Nutrition 0.000 description 2
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 2
- 229940117893 apigenin Drugs 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000005779 cell damage Effects 0.000 description 2
- 208000037887 cell injury Diseases 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000001906 cholesterol absorption Effects 0.000 description 2
- 201000006368 chronic pyelonephritis Diseases 0.000 description 2
- 239000000470 constituent Substances 0.000 description 2
- UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 2
- 229960003957 dexamethasone Drugs 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000000378 dietary effect Effects 0.000 description 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical compound C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 2
- 229930004069 diterpene Natural products 0.000 description 2
- 125000000567 diterpene group Chemical group 0.000 description 2
- HHEAADYXPMHMCT-UHFFFAOYSA-N dpph Chemical compound [O-][N+](=O)C1=CC([N+](=O)[O-])=CC([N+]([O-])=O)=C1[N]N(C=1C=CC=CC=1)C1=CC=CC=C1 HHEAADYXPMHMCT-UHFFFAOYSA-N 0.000 description 2
- 230000004438 eyesight Effects 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 150000002212 flavone derivatives Chemical class 0.000 description 2
- 150000002213 flavones Chemical class 0.000 description 2
- 229960002074 flutamide Drugs 0.000 description 2
- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 2
- 230000007760 free radical scavenging Effects 0.000 description 2
- 210000004919 hair shaft Anatomy 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 210000004969 inflammatory cell Anatomy 0.000 description 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 2
- 229960000310 isoleucine Drugs 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 238000011068 loading method Methods 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 231100000252 nontoxic Toxicity 0.000 description 2
- 230000003000 nontoxic effect Effects 0.000 description 2
- 230000001575 pathological effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 208000008742 seborrheic dermatitis Diseases 0.000 description 2
- 230000003248 secreting effect Effects 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 210000003859 smegma Anatomy 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 150000003648 triterpenes Chemical class 0.000 description 2
- 239000004474 valine Substances 0.000 description 2
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 1
- GXWUEMSASMVWKO-GNLHUFSQSA-N (4as,6ar,6as,6br,10s,12ar,14br)-10-[(2s,3r,4s,5s)-4,5-dihydroxy-3-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-2,2,6a,6b,9,9,12a-heptamethyl-1,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid Chemical compound O([C@@H]1[C@@H](O)[C@@H](O)CO[C@H]1O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CCC2C1(C)C)C)(C)CC[C@]1(CCC(C[C@@H]14)(C)C)C(O)=O)[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O GXWUEMSASMVWKO-GNLHUFSQSA-N 0.000 description 1
- VAJVDSVGBWFCLW-UHFFFAOYSA-N 3-Phenyl-1-propanol Chemical compound OCCCC1=CC=CC=C1 VAJVDSVGBWFCLW-UHFFFAOYSA-N 0.000 description 1
- IVCZEZUJCMWBBR-UHFFFAOYSA-N 7-O-beta-D-glucopyranosyl-7,3',4'-trihydroxyflavone Natural products OC1C(O)C(O)C(CO)OC1OC1=CC=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 IVCZEZUJCMWBBR-UHFFFAOYSA-N 0.000 description 1
- 102000016912 Aldehyde Reductase Human genes 0.000 description 1
- 108010053754 Aldehyde reductase Proteins 0.000 description 1
- 206010002660 Anoxia Diseases 0.000 description 1
- 241000976983 Anoxia Species 0.000 description 1
- FKIYLTVJPDLUDL-ZWUNSDNISA-N Apigenin 7-O-rutinoside Natural products O(C[C@@H]1[C@@H](O)[C@H](O)[C@H](O)[C@H](Oc2cc(O)c3C(=O)C=C(c4ccc(O)cc4)Oc3c2)O1)[C@H]1[C@@H](O)[C@@H](O)[C@@H](O)[C@H](C)O1 FKIYLTVJPDLUDL-ZWUNSDNISA-N 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 206010003591 Ataxia Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000756943 Codonopsis Species 0.000 description 1
- 208000032170 Congenital Abnormalities Diseases 0.000 description 1
- 206010010356 Congenital anomaly Diseases 0.000 description 1
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 1
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 1
- 229930105110 Cyclosporin A Natural products 0.000 description 1
- LEVWYRKDKASIDU-QWWZWVQMSA-N D-cystine Chemical compound OC(=O)[C@H](N)CSSC[C@@H](N)C(O)=O LEVWYRKDKASIDU-QWWZWVQMSA-N 0.000 description 1
- 241001074093 Echinopsis Species 0.000 description 1
- 108090000371 Esterases Proteins 0.000 description 1
- 108010023832 Florigen Proteins 0.000 description 1
- 206010016936 Folliculitis Diseases 0.000 description 1
- 229930188400 Gardenin Natural products 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 208000025309 Hair disease Diseases 0.000 description 1
- 239000009636 Huang Qi Substances 0.000 description 1
- 206010021143 Hypoxia Diseases 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- FKIYLTVJPDLUDL-SLNHTJRHSA-N Isorhoifolin Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC=2C=C3C(C(C=C(O3)C=3C=CC(O)=CC=3)=O)=C(O)C=2)O1 FKIYLTVJPDLUDL-SLNHTJRHSA-N 0.000 description 1
- FKIYLTVJPDLUDL-FLPYCHHVSA-N Isorhoifolin Natural products C[C@H]1O[C@@H](OC[C@H]2O[C@@H](Oc3cc(O)c4C(=O)C=C(Oc4c3)c5ccc(O)cc5)[C@H](O)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H](O)[C@@H]1O FKIYLTVJPDLUDL-FLPYCHHVSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 241001113846 Loganiaceae Species 0.000 description 1
- 206010025476 Malabsorption Diseases 0.000 description 1
- 208000004155 Malabsorption Syndromes Diseases 0.000 description 1
- ZFMITUMMTDLWHR-UHFFFAOYSA-N Minoxidil Chemical compound NC1=[N+]([O-])C(N)=CC(N2CCCCC2)=N1 ZFMITUMMTDLWHR-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 208000022873 Ocular disease Diseases 0.000 description 1
- 102000004316 Oxidoreductases Human genes 0.000 description 1
- 108090000854 Oxidoreductases Proteins 0.000 description 1
- DYUQAZSOFZSPHD-UHFFFAOYSA-N Phenylpropyl alcohol Natural products CCC(O)C1=CC=CC=C1 DYUQAZSOFZSPHD-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 206010034960 Photophobia Diseases 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- 229940123934 Reductase inhibitor Drugs 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 229930003270 Vitamin B Natural products 0.000 description 1
- 238000001467 acupuncture Methods 0.000 description 1
- 235000004279 alanine Nutrition 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 150000001336 alkenes Chemical class 0.000 description 1
- 208000004631 alopecia areata Diseases 0.000 description 1
- JZVFJDZBLUFKCA-FXIAWGAOSA-N alpha-Spinasterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@@H](CC[C@@]3([C@@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)CC[C@H]33)C)C3=CC[C@H]21 JZVFJDZBLUFKCA-FXIAWGAOSA-N 0.000 description 1
- JZVFJDZBLUFKCA-UTQQLQBSSA-N alpha-spinasterol Natural products CC[C@H](C=C[C@H](C)[C@H]1CC[C@H]2C3=CC[C@@H]4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C JZVFJDZBLUFKCA-UTQQLQBSSA-N 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000007953 anoxia Effects 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000002280 anti-androgenic effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 230000036506 anxiety Effects 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000003704 aspartic acid Nutrition 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 230000036770 blood supply Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 230000004663 cell proliferation Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 230000002254 contraceptive effect Effects 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 229960004397 cyclophosphamide Drugs 0.000 description 1
- 229960000978 cyproterone acetate Drugs 0.000 description 1
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000002354 daily effect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000003748 differential diagnosis Methods 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 230000007937 eating Effects 0.000 description 1
- 230000002500 effect on skin Effects 0.000 description 1
- 230000008451 emotion Effects 0.000 description 1
- 230000008694 endothelial dysfunction Effects 0.000 description 1
- 210000003989 endothelium vascular Anatomy 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 238000003810 ethyl acetate extraction Methods 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 208000030533 eye disease Diseases 0.000 description 1
- 229960004039 finasteride Drugs 0.000 description 1
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000001261 florigenic effect Effects 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 238000001415 gene therapy Methods 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 150000008131 glucosides Chemical class 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 239000000745 gonadal hormone Substances 0.000 description 1
- 239000003163 gonadal steroid hormone Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 230000003648 hair appearance Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 241000411851 herbal medicine Species 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 230000007365 immunoregulation Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
- 238000001764 infiltration Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 239000010977 jade Substances 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- PEFNSGRTCBGNAN-QNDFHXLGSA-N luteolin 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C=C(C=3C=C(O)C(O)=CC=3)OC2=C1 PEFNSGRTCBGNAN-QNDFHXLGSA-N 0.000 description 1
- QZOVLVSTWSTHQN-UHFFFAOYSA-N luteolin 7-O-glucoside Natural products OCC1OC(Oc2cc(O)c3C(=O)C=C(C(=O)c3c2)c4ccc(O)c(O)c4)C(O)C(O)C1O QZOVLVSTWSTHQN-UHFFFAOYSA-N 0.000 description 1
- KBGKQZVCLWKUDQ-UHFFFAOYSA-N luteolin-glucoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC2=C1C(=O)C=C(C=1C=C(O)C(O)=CC=1)O2 KBGKQZVCLWKUDQ-UHFFFAOYSA-N 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 229960003632 minoxidil Drugs 0.000 description 1
- VYQNWZOUAUKGHI-UHFFFAOYSA-N monobenzone Chemical compound C1=CC(O)=CC=C1OCC1=CC=CC=C1 VYQNWZOUAUKGHI-UHFFFAOYSA-N 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000036542 oxidative stress Effects 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000010412 perfusion Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 230000004962 physiological condition Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000004036 potassium channel stimulating agent Substances 0.000 description 1
- 208000037920 primary disease Diseases 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 235000020095 red wine Nutrition 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 210000004927 skin cell Anatomy 0.000 description 1
- LXMSZDCAJNLERA-ZHYRCANASA-N spironolactone Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CCC(=O)C=C4C[C@H]([C@@H]13)SC(=O)C)C[C@@]21CCC(=O)O1 LXMSZDCAJNLERA-ZHYRCANASA-N 0.000 description 1
- 229960002256 spironolactone Drugs 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 230000003813 thin hair Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 231100001265 toxicological assessment Toxicity 0.000 description 1
- 238000009602 toxicology test Methods 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 210000004509 vascular smooth muscle cell Anatomy 0.000 description 1
- 210000001835 viscera Anatomy 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 239000000341 volatile oil Substances 0.000 description 1
- 238000003809 water extraction Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a new application of traditional Chinese medicine buddleja officinalis and provides an application of buddleja officinalis in the preparation of medicines for preventing or treating alopecia. The traditional Chinese medicine buddleja officinalis can be used for promoting the growth of hairs and thickening the hairs, is distinct in curative effect, contains rich nutrients, and is low in price, and safe and convenient in use.
Description
Technical field
The present invention relates to new purposes, the especially Flos Buddlejae application in the medicine of prevention or treatment baldness of Flos Buddlejae.
Background technology
Hair is the appurtenance of scalp, is made up of hair papilla, hair follicle, Rhizoma Imperatae and hair shaft.The part that hair is exposed at the skin outside is called hair shaft; The part that is embedded in the skin the inside is called Rhizoma Imperatae; The part that expand slightly the Rhizoma Imperatae lower end is called hair follicle; The hair follicle lower end is recessed part and is called hair papilla, and teleneuron, blood vessel and connective tissue from dermal tissue are arranged in hair papilla, for the growth of hair provides nutrition.If hair papilla is destroyed or degenerates, hair just stops growing, and comes off gradually.On hair follicle top, also have the opening of a sebaceous gland, the oils and fats of smegma is discharged by pore, is moistening hair, and can be according to its excretory attribute that how much decides hair, as: neutral, oiliness and dryness.The basis of hair is keratoprotein, and keratoprotein is made up of 18 seed amino acids, and other contains various trace elements.
Hair grows in the hair follicle and comes off, and roughly is divided into three phases, i.e. trophophase, catagen and resting stage.The sustainable 4-6 of trophophase, even longer, hair are and enliven proliferative state; Catagen schedules to last 2-3 week, and the positive hypertrophy of hair stops, and forms club hair; Resting stage schedules to last about 3 months, and in this stage, hair follicle is atrophy gradually, near old and feeble hair follicle, forms 1 trophophase ball top again, last old falling out.Normal physiologic alopecia; Come off 50～100 every day; For being in the hair of catagen or resting stage; Constantly be in dynamic equilibrium owing to get into catagen with the new hair that gets into trophophase, thus the hair of normal quantity can be kept, and clinical said alopecia is meant that the hair that is in trophophase comes off unusually or excessively.
Alopecia is clinical common hair diseases, causes puzzlement for easily patients ' psychological, spirit and life.Cause the factor more complicated of alopecia, the congenital heredity factor is arranged, the pathological factor day after tomorrow is also arranged.From the etiology angular divisions, mainly contain: trophism alopecia, androgenetic alopecia, alopecia of chemical origin, physical property alopecia, hereditary alopecia etc.The method of at present treating alopecia has a lot; Comprise the traditional Chinese medical science classical prescription, test room, folk prescription, acupuncture, massage etc.; The medicine of the hormone of doctor trained in Western medicine, antibacterial, lotion, hair follicle stimulating growth, optical treatment, hair grafting operative treatment, gene therapy etc., or composite treatment.In the tcm prescription there be: Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Chuanxiong, Fructus Lycii, the Radix Astragali, Semen Cuscutae, Fructus Ligustri Lucidi, Herba Ecliptae, the Radix Paeoniae Alba, Radix Codonopsis, the Radix Rehmanniae, Flos Carthami, Semen Sesami Nigrum, Radix Salviae Miltiorrhizae etc. the Chinese medicine of invigorating the liver and kidney commonly used, benefiting essence-blood.Doctor trained in Western medicine medicament commonly used is: reductase inhibitor, finasteride; The androgen receptor protein blocker, cimetidine, cyproterone acetate, spironolactone, dexamethasone, flutamide; The anti-androgens medicine, dexamethasone, flutamide; The potassium-channel opener, minoxidil; Ciclosporin A; Vitamin etc.But the curative effect that has is not significantly, treatment cycle is long, side effect is arranged, or contains expensive composition, patient's difficulty of making up a prescription, and might show effect repeatedly, therapeutic effect is all not ideal enough.And Flos Buddlejae is used for prevention or treatment baldness, does not see relevant report at present as yet.
Flos Buddlejae is dry flower and the inflorescence thereof of loganiaceae plant Flos Buddlejae Buddleja officinalis Maxim.." record of Chinese pharmacopoeia version in 2010: [nature and flavor with return through] are sweet, are slightly cold, and return Liver Channel; [function with cure mainly] heat clearing away nourishing the liver, improving acuity of vision and removing nebula is used for: conjunctival congestion and swelling pain, many tear photophobia, the nebula of looking unfamiliar film, hepatasthenia dim eyesight, blurring of vision." Kaibao Bencao ": sweet in the mouth, be slightly cold, nontoxic.It is yellow that the Flos Buddlejae hot-water soak is, and good stability, strong coloring force, and aromatic odor is arranged, and therefore the Flos Buddlejae hot-water soak liquid that utilizes among the people is for many years made food color perfumings such as multicolored meal.Wei Xianfei etc. publish an article " toxicological assessment of Yellow plgment of buterflybush flower " (" Guangxi prevention science ": 1998,4 (4)) explain: through toxicology test, the Flos Buddlejae safety non-toxic.Therefore, Flos Buddlejae is the food and medicament dual-purpose natural active matter with good health care.
Flos Buddlejae contains several amino acids, vitamin, trace element, flavone and glycoside thereof, triterpene and saponins thereof, benzene second glycoside, Diterpenes, volatilization wet goods composition.The inventor entrusts Analysis-Test Research Center, Guangxi Zhuang Autonomous Region to detect and finds that Flos Buddlejae contains 17 seed amino acids of needed by human body, abundant vitamin and wholesome trace element.Flavone and glycoside composition thereof have: buddleo-glucoside, Flos Buddlejae glycosides (being acacetin), apigenin, luteolin, linarin, the new glycosides of Flos Buddlejae, autumn English glycosides, different foreign ligustrin, apigenin-7-O-rutinoside, luteolin-7-O-glucoside, apigenin-7-O-rutin glucosides verbascoside.Triterpene and saponin component thereof have: oleanolic acid-13-(18)-alkene-3-ketone, 8-Amyrin-8,24-diene-3-alcohol acetic ester, bessisterol, galactitol, coumaric acid, Flos Buddlejae saponin third, the plain glycosides of a phenylpropyl alcohol, Flos Buddlejae glycosides A, Flos Buddlejae glycosides B.The phenethyl alcohol glycoside constituents has: verbascoside (being foreign ligustrin), different foreign ligustrin, different verbascoside, Caulis Echinopsis Multiplicis glycosides.The Diterpenes composition mainly contains crocin.Still contain abundant volatile oil composition in the Flos Buddlejae, mainly comprise 8 compounds such as ketone, acid, alkane, ester, alcohol, alkene, biphenyl and heterocycle, wherein flavonoid content is higher relatively.
Yellow plgment of buterflybush flower be Flos Buddlejae after water or alcohol extraction, filter, concentrate, dry and get, be the natural pigment of edible safety." research of natural edible Yellow plgment of buterflybush flower " that Hao Jinsheng etc. deliver (" research and development of natural products ": 1994,6 (2)) show: adopt said extraction process, the extraction ratio >=l5% of Yellow plgment of buterflybush flower.Its main chemical is: crocin, Flos Buddlejae glycosides (being acacetin).Crocin (crocin), another name: crocin, crocin, Stigma Croci florigen, Stigma Croci glycosides, Crocin, saffron glucoside-II, gardenin are the croceous effective ingredient of rare Chinese medicine.
Flos Buddlejae is usually used in the treatment of ocular disease, is the ophthalmology key medicine.Modern pharmacological research finds, Flos Buddlejae improves immunity, antioxidation, prevention and delaying complications of diabetes, antibacterial, antiinflammatory, the dermovascular permeability of reduction and fragility, protection endothelium in addition, suppress endotoxin causes endotheliocyte oxidative damage and effects such as apoptosis, blood fat reducing.Concrete research situation is:
(1) Wu Kefeng etc. " Flos Buddlejae is to the immunoregulation effect of normal and immunocompromised mice " (" Guiyang Medical College journal " the 4th phase in 1997) of delivering shows: Flos Buddlejae fries in shallow oil that immune function of mice that extract causes cyclophosphamide is impaired to have certain antagonism.
(2) " Flos Buddlejae total flavones antioxidant activity " (" spectroscopic test chamber " the 3rd phase in 2011) of delivering such as Cai Lingyun: use the antioxidation activity in vitro size of the DPPH free radical scavenging activity being investigated Flos Buddlejae; And do comparison with vitamin C with concentration; The result shows; Flos Buddlejae is stronger than vitamin C to the effect of DPPH free radical scavenging, and Flos Buddlejae is a kind of good Natural antioxidant.
(3) " Flos Buddlejae chemical constituent and activity research thereof " (" Chinese herbal medicine ": 2004 of delivering such as Han Peng; 35 (10)) show: Flos Buddlejae extract kind linarin, apigenin and different foreign ligustrin have strong aldose reductase inhibition activity; Suppression ratio all is higher than the positive control Quercetin, and Flos Buddlejae can prevent and delaying complications of diabetes in prompting; Total flavones in the Flos Buddlejae has significantly antibiotic (staphylococcus aureus and Hemolytic streptococcus) activity with total phenethyl alcohol glycoside on cellular level, active component wherein is Flos Buddlejae glycosides and foreign ligustrin.
(4) Wang Hongzai " Flos Buddlejae research overview " (" time precious traditional Chinese medical science traditional Chinese medicines ", 2000,11 (1)) statement: the oral acacetin of mice, can alleviate formaldehyde property inflammation, can also reduce the permeability and the fragility of skin, vasa intestinae tenuis.
(5) " crocin antioxidation with to vascular endothelial cell secretion ET-1 influence " (" academic annual meeting in 2004 of Chinese animal and veterinary traditional Chinese veterinary medicine branch of association ") of delivering of Liu Juan shows: crocin can be removed free radical, anti peroxidation of lipid, has the effect of protection endothelium.Endothelium is kept the integrity and the function of blood vessel wall as the barrier between blood vessel wall and the blood.Under the normal physiological situation, endotheliocyte can be regulated the related activity composition makes antiotasis keep normal, keeps the perfusion of organ.And under some pathologic condition, this balance is destroyed, and vascular endothelium dysfunction takes place.When vascular endothelial cell impaired; Then thrombosis (differential diagnosis in tcm belongs to blood stasis more) forms, and inflammatory cell infiltration, mononuclear cell and vascular endothelial cell stick and get into endotheliocyte; In case inflammatory cell intravasation wall; The oxygen-derived free radicals molecule that discharges high reaction activity causes the oxidative stress of vascular endothelial cell, makes blood vessel inner skin cell function disorderly, gets into vicious cycle.Show as minimizing of NO and other relaxing factors or active the reduction, and Endothelin discharges increase etc.Secretory function before and after the crocin scalable endothelial cell damage reduces the secretion of Endothelin, in order to avoid Endothelin supersecretion and cause the blood vessel excess shrinkage.
(6) " crocin is to the influence of endotoxin hyperamization endothelial cell oxidative damage " (" Chinese animal and veterinary traditional Chinese veterinary medicine branch of association academic nd Annual Meeting in 2005 ") of delivering such as Liu Juan shows: crocin can suppress endotoxin and cause endotheliocyte oxidative damage and apoptosis.
(7) the jade of money " crocin transfer blood fat Mechanism Study " (" Chinese licensed pharmacist " the 2nd phase in 2009) of delivering shows: suppress fat and cholesterol absorption in the time of the crocin blood fat reducing.
Summary of the invention
The present invention seeks to avoid the deficiency of existing above-mentioned therapy, the new purposes of a kind of Chinese medicine Flos Buddlejae is provided, be i.e. the purposes of Flos Buddlejae in the medicine of preparation prevention or treatment baldness.
The inventor is through clinical trial and observe discovery, when taking Chinese medicine Flos Buddlejae treatment oculopathy, alopecia is had improvement in various degree, and originally thin hair becomes close, and the alopecia place also grows New Development, can be used for prevention or treatment baldness.
Preliminary study thinks that Flos Buddlejae can be used for preventing or treats because the alopecia due to the malnutrition; And can promote natural on-off cycles of hair growth, make hair sturdy.Also can be used for prevention or treatment androgenetic alopecia.
For more being expressly understood feature and advantage of the present invention, according to the clinical trial situation experiment and the theoretical research of deriving them described in more detail at present.
One, Flos Buddlejae is used to prevent or treats because the alopecia due to the malnutrition; And can promote natural on-off cycles of hair growth, make hair sturdy.
Hair is the most vigorous position of human body cell division; The a lot of nutrition of the growth needs of hair; When malnutrition takes place when, body except that some organ or systemic disease take place in meeting, also can occur the attenuating of hair, thinning, bleach, be prone to broken, a series of variations such as alopecia.Due to the malnutrition there be the reason of alopecia: dietary deficiency, specific physiological condition (like anemia of pregnant woman, puerpera), long-term anxiety and anxiety state, use some drugs (like chemotherapy) etc.The nutrient substance that needs in the natural on-off cycles of hair growth process is mainly: protein, aminoacid, vitamin and trace element.Protein is the basis of natural on-off cycles of hair growth, and human body is digested and assimilated in vivo and resolved into each seed amino acid through food intake protein, gets into hair papilla through blood, is absorbed and accumulated angle albumen, after keratinization, grows into hair again.This shows that protein and aminoacid are to the importance of hair.
The inventor entrusts Analysis-Test Research Center, Guangxi Zhuang Autonomous Region to detect; The result shows; Flos Buddlejae contains 17 seed amino acids of needed by human body: alanine, valine, leucine, isoleucine, proline, phenylalanine, methionine, glycine, serine, tyrosine, lysine, arginine, histidine, Aspartic Acid, glutamic acid, cystine, threonine; Amino acid whose total amount is 3.556g/100g; Than the total amino acid content in the extra dry red wine Fructus Jujubae also high (about 3g/100g), wherein: valine, leucine, isoleucine, phenylalanine, methionine, lysine, threonine are that human body must aminoacid.Other contains abundant vitamin such as vitamin C, vitamin B, and trace element such as wholesome calcium, phosphorus.These nutrient substance are that natural on-off cycles of hair growth is necessary, can promote natural on-off cycles of hair growth after taking, and make hair sturdy.
Hair is constantly grown because of division, increment, the differentiation of the hair follicle of Rhizoma Imperatae portion; Hair follicle is then supplied with necessary various nutrient substance by the blood capillary in the hair papilla; If nutrient malabsorption appears in the blood supply insufficiency at hair follicle, hair papilla position, also can cause alopecia.Crocin in the Flos Buddlejae can be removed free radical, anti peroxidation of lipid, has the effect of protection vascular endothelial cell, promotes the blood circulation of the blood capillary in the hair papilla, thereby promotes natural on-off cycles of hair growth.
Two, Flos Buddlejae is used for prevention or treatment androgenetic alopecia.
Androgenetic alopecia is claimed seborrheic alopecia, alopecia areata, diffusion-type alopecia, male pattern alopecia or heritability alopecia etc. again.This disease shows as excessive the overflowing of patient's scalp fat, often increases with dandruff, and scalp is greasy, and pruritus is obvious.Pilosity is born in the vigorous person between twenty and fifty of smegma.The general hair of patient is soft, have also with brawny tetter dermatitis symptom.Beginning spreads and forehead gradually from the head alopecia, fills the air then in the whole crown.Scalp is greasy and azarin is tied yellow oiliness crust.
The primary disease pathogeny is complicated.Chinese medicine thinks that the morbidity of androgenetic alopecia is by incoordination of seven emotions, eating and drinking without temperance, overstrain or congenital defect, causes internal organs deficient, disorder of QI and blood, and Rhizoma Imperatae is hollow, due to the hair mistake is supported.Modern medicine is not illustrated this as yet fully, though study generation that oneself shows androgenetic alopecia seldom be in the blood circulation androgen too much due to, generally speaking androgen is the indispensable necessary factor of morbidity.Relatively more consistent view is: emerald green ketone generates the emerald green ketone of dihydro under the effect of 5a one reductase; After special androgen receptor combines on the emerald green ketone of dihydro and the target organ; Just begin to regulate and control the secretion of sebaceous gland; Stimulate the hypertrophy of sebaceous gland and increasing of sebum secretion, thereby promoted the generation of androgenetic alopecia.
The Chinese medical discrimination of the present invention's prevention or treatment androgenetic alopecia is derived.Flos Buddlejae, sweet, be slightly cold, return Liver Channel; Function with cure mainly: the heat clearing away nourishing the liver.Flos Buddlejae goes into Liver Channel, blood system, but expelling wind and clearing away heat, and it is dry to moisten liver again, nourishing the liver blood.Liver controlling conveyance and dispersion, store blood and accent blood.The traditional Chinese medical science is thought " hair is the sign of blood condition ", is that taking good care of of sending out of explanation derives from blood, and liver blood is full, sends out to be able to support.Blood deficiency, heat in blood, blood stasis all can cause alopecia, and the effect that Flos Buddlejae has clearing away heat and cooling blood, nourishing the liver to enrich blood, transfer blood to invigorate blood circulation so sending out of using is able to nutrition, promotes growth.
The modern pharmacological research of the present invention's prevention or treatment androgenetic alopecia.Flos Buddlejae has improves immunity, antioxidation, and Flos Buddlejae contains rich nutrient substances: the trace element of the aminoacid of 17 kinds of needed by human body, abundant vitamin and useful hair, and for the growth of hair provides prescribing adequate nutrition.Zhou Qing etc. discover that androgenetic alopecia and hemorheology variation exist dependency, microcirculation disturbance that the hair follicle peripheral vessels is shunk, and stimulate the vascular smooth muscle cell proliferation; Finally make the ischemia anoxia, cause carrying out property of hair follicle to be dwindled, and the crocin in the Flos Buddlejae can be removed free radical, anti peroxidation of lipid; Secretory function before and after the effect with protection blood vessel endothelium, scalable endothelial cell damage reduces the secretion of Endothelin; In order to avoid Endothelin supersecretion and cause the blood vessel excess shrinkage; Blood circulation promoting, the blood capillary of expansion hair papilla, thereby mediation hair follicle.Crocin also has the effect of blood fat reducing in the Flos Buddlejae, suppresses fat and cholesterol absorption simultaneously, thereby reduces the hair follicle sebaceous secretion.In most of androgenetic alopecia dermatitis scalp infringements; Can find lipotropy, polymorphic oval pityrosporum furfur, this bacterium can be decomposed into serum levels of triglyceride the esterase of zest lipase, can influence the regeneration of epidermis; And cause inflammation and produce dandruff; Form seborrheic dermatitis companion alopecia, that Flos Buddlejae has is antibacterial, antiinflammatory, the dermovascular permeability of reduction and fragility effect, can suppress seborrheic dermatitis.In sum, Flos Buddlejae is through improving immunity, blood circulation promoting; The control sebum secretion suppresses scalp antibacterial, inflammation, thereby regulates the body sex hormone level on the whole; Reduce pilosebaceous secretion, reach the purpose of prevention or treatment androgenetic alopecia disease.
The present invention is used to process the medicine that prevents or treat the above baldness; Said medicine adds the pharmaceutical preparation that pharmaceutically acceptable carrier or complementary composition are prepared from for being active component with Flos Buddlejae crude drug powder, Flos Buddlejae water extract or extractive with organic solvent.Said organic solvent is well known to those skilled in the art, as: methanol, ethanol, isopropyl alcohol, acetone, n-butyl alcohol or ethyl acetate etc.As preferably, said Flos Buddlejae extractive with organic solvent is ethanol extraction, n-butanol extract or ethyl acetate extract, further is preferably the ethanol extraction of 30%-85%.Also can in preparation, add corresponding medicine or nutritional labeling, be mixed with the pharmaceutical composition that contains Flos Buddlejae according to state of an illness needs.
Said pharmaceutical preparation is this area preparation commonly used, as: oral liquid, capsule, decoction, tablet or granule etc., use as medication or dietary product; As preferably, be prepared into capsule, oral liquid or decoction.
The method for preparing of the above Flos Buddlejae water extract is: get the Flos Buddlejae medical material, add 8-10 times of water gaging, heating decocts 2 times, and each 0.5-1 hour, filter, merging filtrate promptly gets.
The method for preparing of the above Flos Buddlejae ethanol extraction is: gets the Flos Buddlejae medical material, adds the ethanol that 6-8 doubly measures 30%-85%, and heating and refluxing extraction 2-3 time, each 0.5-2 hour, filter, merging filtrate reclaims ethanol, promptly gets.
The method for preparing of the above Flos Buddlejae n-butanol extract is: gets the Flos Buddlejae medical material, adds 6-8 and doubly measure n-butyl alcohol, and heating and refluxing extraction 2-3 time, each 0.5-2 hour, filter, merging filtrate reclaims n-butyl alcohol, promptly gets.
The method for preparing of the above Flos Buddlejae ethyl acetate extract is: gets the Flos Buddlejae medical material, adds 6-8 and doubly measure ethyl acetate, and heating and refluxing extraction 2-3 time, each 0.5-2 hour, filter, merging filtrate reclaims ethyl acetate, promptly gets.
The method that Flos Buddlejae is prepared into capsule is: get water extract and/or the extractive with organic solvent of above-mentioned Flos Buddlejae, be condensed into thick paste, add appropriate amount of starch, drying is pulverized, and sieves, and adds an amount of filler, lubricant again, and mixing incapsulates, and promptly gets.
The method that Flos Buddlejae is prepared into oral liquid is: get water extract and/or the extractive with organic solvent of above-mentioned Flos Buddlejae, concentrate, add an amount of stabilizing agent, antiseptic or correctives, mixing filters, and adds suitable quantity of water, mixing, and fill, sterilization promptly gets.
The invention has the beneficial effects as follows:
(1) can prevent or treat baldness, promote natural on-off cycles of hair growth, make hair sturdy, evident in efficacy.
(2) Flos Buddlejae contains rich nutrient substances, is " integration of edible and medicinal herbs " kind, and is cheap, safe in utilization, convenient.
The specific embodiment
Below in conjunction with specific embodiment and clinical practice the present invention is further described, but does not limit protection scope of the present invention and range of application:
One, the preparation of sample
Embodiment 1 Flos Buddlejae crude drug powder
Get Flos Buddlejae medical material 50kg, be ground into fine powder, cross 80 mesh sieves, divide to be filled in the capsule, promptly get.The content of Flos Buddlejae crude drug powder is: the 0.5g/ grain.
Embodiment 2. Flos Buddlejae decoctions
Get Flos Buddlejae medical material 10g, add 8 times of water gagings, heating decocted 30 minutes, filtered, and filtering residue adds 6 times of water gagings again, and heated and boiled 30 minutes filters, and merging filtrate promptly gets.
Embodiment 3 Flos Buddlejae capsules
Get Flos Buddlejae medical material 50kg, add 10 times of water gagings, heating decocts 2 times, and each 1 hour, filter, merging filtrate is condensed into thick paste, adds appropriate amount of starch, and drying is pulverized, and sieves, and adds an amount of filler, lubricant again, and mixing incapsulates, and promptly gets.Contain Flos Buddlejae crude drug powder: the 1g/ grain.
Embodiment 4 Flos Buddlejae capsules
Get Flos Buddlejae medical material 50kg, add 6 times of amount 85% ethanol, heating and refluxing extraction 3 times each 0.5 hour, filters merging filtrate; Reclaim ethanol, be condensed into thick paste, add appropriate amount of starch, drying is pulverized; Sieve, add an amount of filler, lubricant again, mixing incapsulates, and promptly gets.Contain Flos Buddlejae crude drug powder: the 1g/ grain.
Embodiment 5 Flos Buddlejae capsules
Get Flos Buddlejae medical material 50kg, add 7 times of amount n-butyl alcohol, heating and refluxing extraction 2 times each 1 hour, filters merging filtrate; Reclaim n-butyl alcohol, be condensed into thick paste, add appropriate amount of starch, drying is pulverized; Sieve, add an amount of filler, lubricant again, mixing incapsulates, and promptly gets.Contain Flos Buddlejae crude drug powder: the 1g/ grain.
Embodiment 6 Flos Buddlejae oral liquids
Get Flos Buddlejae medical material 50kg, add 7 times of amount ethyl acetate, heating and refluxing extraction 3 times, each 0.5 hour, filter, merging filtrate reclaims ethyl acetate, and is subsequent use; Get the filtering residue behind the ethyl acetate extraction, add 8 times of water gagings, heating decocts 2 times, each 1 hour, filters merging filtrate; The extract that reclaims after the ethyl acetate is merged with the filtrating that water extraction obtains, and mixing concentrates, and adds an amount of stabilizing agent, antiseptic, correctives, and mixing filters, and adds suitable quantity of water, mixing, and fill is sterilized, and promptly gets.Contain Flos Buddlejae crude drug powder: 3g/ props up, every loading amount 10ml.
Embodiment 7 Flos Buddlejae oral liquids
Get Flos Buddlejae medical material 50kg, add 8 times of amount 30% ethanol, reflux 2 times, each 2 hours, filter, merging filtrate reclaims ethanol, adds an amount of stabilizing agent, antiseptic, correctives, mixing, filters, and adds suitable quantity of water, mixing, sterilization, fill promptly gets.Contain Flos Buddlejae crude drug powder: 3g/ props up, every loading amount 10ml.
Two, case is selected
1. the baldness due to the malnutrition:
(1) symptom: alopecia, hair attenuate, become fragile, and scalp is greasy, and be the same as polishing, and also has shrivelledly to send out fluffy, lacks gloss, have faint yellow squama set difficulty to take off, or the canescence squama flown upward conscious pruritus.
(2) case is selected: totally 45 routine patient or volunteers.Age 18-60 year, average 35 scholars 7 years old.The course of disease: 5 months to 15 years, average 3.1 scholars 2.5 years.Male: 28 examples, women's 27 examples.
2. androgenetic alopecia disease:
(1) symptom: alopecia begins from the forehead both sides, and by stretching to the crown, the hair gradual change is rare, very thin, and newborn hair is more and more thinner, and is soft unable, or from the beginning backs down the beginning alopecia, and the alopecia district is even, sparse, the thin and delicate hair of a slice.Fat secretion is prosperous, and hair is greasy, or scurf is obvious, and hair is dry, companion's pruritus.
(2) case is selected: totally 85 routine patient or volunteers.Age 18-60 year, average 30.5 scholars 7.2 years old.The course of disease: 5 months to 15 years.Average 3.5 scholars 2.4 years.Male: 63 examples, women's 22 examples.
3. include standard in:
(1) age was at 18 1 60 years old.
(2) do not use gonadal hormone contraceptive person nearly March.
(3) nearly 1 month without any alopeciaing therapeutic.
(4) the good person of compliance.
Three, Therapeutic Method: above two types baldness is divided into treatment group, negative control group, adopts the randomized, double-blind method.2 months is a course of treatment, and curative effect is judged in drug withdrawal after 1 month, avoids pungent, sweet greasy article during this period, keeps happy, and daily life is regular.
1. the baldness treatment group due to the malnutrition: the patient takes Flos Buddlejae crude drug powder, Flos Buddlejae decoction, Flos Buddlejae oral liquid, Flos Buddlejae capsule respectively at random.Above-mentioned each embodiment is used for 3 routine patients at least.
2. androgenetic alopecia disease treatment group: the patient takes Flos Buddlejae crude drug powder, Flos Buddlejae decoction, Flos Buddlejae oral liquid, Flos Buddlejae capsule respectively at random.Above-mentioned each embodiment is used for 3 routine patients at least.
3. negative control group: take the oral liquid that does not have the Flos Buddlejae medical material to the patient respectively.
4. dosage: Flos Buddlejae primary crude drug powder (15/day), Flos Buddlejae decoction (getting the 10g medical material every day, the preparation of the decoction under the article method for preparing item in the same old way), Flos Buddlejae oral liquid (3/day), Flos Buddlejae capsule (8/day).
Four, observed content and method
1. alopecia: a small amount of alopecia: a day alopecia is less than 50, record " +++"; The alopecia of middle amount: day alopecia, is write down " ++ " less than 100 greater than 50; A large amount of alopecias: day alopecia is write down "+" greater than 100.
2. send out the evaluation of axle microcosmic: send out the axle chap, record " +++"; It is constant to send out axle, record " ++ "; Send out axle and attenuate, record "+".
3. tension test: difficulty is broken, and hot strength strengthens, record " +++"; Hot strength is constant, record " ++ "; Be prone to break record "+".
4. New Development growing state: alopecia place all grows hair, record " +++"; The alopecia director goes out 1/3 above New Development, record " ++ "; Do not grow New Development, record "+".
Five, therapeutic outcome: in time T
0(treatment beginning before), in time T
1(treating end in 2 months), in time T
2(stopping administration 1 month) estimated respectively, and above-mentioned three groups of clinical trial situation are added up, and sees following table for details:
Above-mentioned therapeutic outcome shows: 25 examples are organized in the baldness treatment due to the malnutrition, recovery from illness 76%, effective 96%, invalid 4%; 65 examples are organized in the treatment of androgenetic alopecia disease, recovery from illness 76%, effective 97%, invalid 3%; Two groups of negative control group all do not have the effect of improvement to alopecia.Above-mentioned data have significance meaning (P < 0.05) through statistical procedures difference.Treatment group simultaneously is visible improves patient's scalp fat secretion, and sebum secretion is moderate, and the scalp tumor is itched and greasy scales obviously reduces, and hair increases slightly.The period in a medicine appearance that all has no adverse reaction.Below be several model cases:
Model case 1: open * *, woman, 38 years old.Malnutrition, physical weakness began alopecia before 5 years, and every day, the 100-200 root caused the whole hair of head sparse, and hair attenuates, becomes fragile simultaneously, shrivelledly sends out fluffy, lacks gloss.Be diagnosed as the trophism alopecia.Take embodiment 1 Flos Buddlejae crude drug powder after 20 days, begin to grow New Development, after 2 months, the alopecia director goes out denser hair, sends out the axle chap, and hair is glossy, and alopecia reduces, no pruritus phenomenon.
Model case 2: the king * *, woman, 52 years old.Be in hospital because of chronic pyelonephritis before 3 years, a large amount of alopecia during the ill and treatment, cure chronic pyelonephritis after alopecia do not take a turn for the better yet, scalp is greasy, the adularescent squama is flown upward, conscious pruritus.The head hair is sparse, and asthenic body is diagnosed as the trophism alopecia.Take embodiment 2 Flos Buddlejae decoctions after 15 days, the visible more black hair follicle growth of scalp after 2 months, grows New Development more than 1 cun, and hair is fine and closely woven, and after 3 months, fine and closely woven hair is sent out a chap.
Model case 3: clock * *, man, 28 years old.Because work strain, life stress are big, from the beginning backed down the beginning alopecia before 2 years, the alopecia district is even, sparse, the thin and delicate hair of a slice, almost sees scalp, and the scalp fat secretion is vigorous, pruritus.Be diagnosed as androgenetic alopecia.Take embodiment 3 Flos Buddlejae capsules after 20 days, the visible more black hair follicle growth of scalp.After 2 months, grow fine and closely woven hair, alopecia obviously reduces, and scalp is conscious does not itch.After 3 months, fine and closely woven hair is sent out a chap.
Model case 4: Zhao * *, man, 35 years old.The a large amount of alopecias of beginning before 3 years, alopecia begins from the forehead both sides, and by stretching to the crown, the hair gradual change is rare, very thin, and visible its forehead to head hair almost takes off light, and only surplus part is fine like fine hair, and scalp pomade is many, with folliculitis.Be diagnosed as androgenetic alopecia.Take embodiment 6 Flos Buddlejae oral liquids after 20 days, the scalp fat secretion reduces, and the hair follicle inflammation is eliminated, the visible more black hair follicle growth of scalp.After 2 months, grow fine and closely woven hair, hair quality is floss slightly, and alopecia obviously reduces.After 3 months, at the beginning of the hair crow Miru.
Claims (10)
1. the purposes of Flos Buddlejae in the medicine of preparation prevention or treatment baldness.
2. the purposes of Flos Buddlejae according to claim 1 is characterized in that, is used for prevention or treatment because alopecia due to the malnutrition.
3. the purposes of Flos Buddlejae according to claim 1 is characterized in that, is used to make hair sturdy.
4. the purposes of Flos Buddlejae according to claim 1 is characterized in that, is used for prevention or treatment androgenetic alopecia.
5. according to the purposes of each described Flos Buddlejae among the claim 1-4; It is characterized in that; Described medicine is to be active component with Flos Buddlejae crude drug powder, Flos Buddlejae water extract or extractive with organic solvent, adds the pharmaceutical preparation that pharmaceutically acceptable carrier or complementary composition are prepared from.
6. the purposes of Flos Buddlejae according to claim 5 is characterized in that, said Flos Buddlejae extractive with organic solvent is ethanol extraction, n-butanol extract or ethyl acetate extract.
7. the purposes of Flos Buddlejae according to claim 5 is characterized in that, the method for preparing of said Flos Buddlejae water extract is: get the Flos Buddlejae medical material, add 8-10 times of water gaging, heating decocts 2 times, and each 0.5-1 hour, filter, merging filtrate reclaims ethanol, promptly gets.
8. the purposes of Flos Buddlejae according to claim 6 is characterized in that, the method for preparing of said Flos Buddlejae ethanol extraction is: get the Flos Buddlejae medical material, add the ethanol that 6-8 doubly measures 30%-85%; Heating and refluxing extraction 2-3 time each 0.5-2 hour, filters; Merging filtrate reclaims ethanol, promptly gets.
9. the purposes of Flos Buddlejae according to claim 6 is characterized in that, the method for preparing of said Flos Buddlejae n-butyl alcohol or ethyl acetate extract is: get the Flos Buddlejae medical material; Add 6-8 and doubly measure n-butyl alcohol or ethyl acetate, heating and refluxing extraction 2-3 time, each 0.5-2 hour; Filter; Merging filtrate reclaims n-butyl alcohol or ethyl acetate, promptly gets.
10. according to the said Flos Buddlejae purposes that contains of claim 5, it is characterized in that said pharmaceutical preparation is capsule, oral liquid or decoction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101806872A CN102657703A (en) | 2012-06-04 | 2012-06-04 | New application of traditional Chinese medicine buddleja officinalis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2012101806872A CN102657703A (en) | 2012-06-04 | 2012-06-04 | New application of traditional Chinese medicine buddleja officinalis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102657703A true CN102657703A (en) | 2012-09-12 |
Family
ID=46767371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2012101806872A Pending CN102657703A (en) | 2012-06-04 | 2012-06-04 | New application of traditional Chinese medicine buddleja officinalis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102657703A (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104055722A (en) * | 2014-06-13 | 2014-09-24 | 昆明密姿娜贸易有限公司 | Preparation method of plant hair-care mixture |
| CN104957594A (en) * | 2015-06-29 | 2015-10-07 | 梁海林 | Preparation method of buddleja officinalis concentrated liquid |
| CN105011114A (en) * | 2015-06-29 | 2015-11-04 | 梁海林 | Preparation method of maple leaf concentrated solution |
| CN105891380A (en) * | 2016-04-22 | 2016-08-24 | 广西壮族自治区梧州食品药品检验所 | Method using ASE method to extract linarin in buddleja officinalis |
| CN106038700A (en) * | 2014-04-18 | 2016-10-26 | 温先敏 | Application of butterflybush flower and extract in preparation of medicine for treating pulmonary heart disease |
| CN110917104A (en) * | 2019-12-12 | 2020-03-27 | 乐芸 | Common tower hair nourishing cream and preparation method thereof |
| CN111568910A (en) * | 2020-07-06 | 2020-08-25 | 上海沸米生物科技有限公司 | Application of crocin II in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissues |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN102119730A (en) * | 2010-12-27 | 2011-07-13 | 陈慧婷 | Formula and preparation method of liver-protecting Mimenghua yoghurt drink |
| CN102302686A (en) * | 2011-07-22 | 2012-01-04 | 陈超 | Medicament for treating xerophthalmia |
-
2012
- 2012-06-04 CN CN2012101806872A patent/CN102657703A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1066584A (en) * | 1991-03-12 | 1992-12-02 | 王乃昭 | Multipurpose tooth paste |
| CN102119730A (en) * | 2010-12-27 | 2011-07-13 | 陈慧婷 | Formula and preparation method of liver-protecting Mimenghua yoghurt drink |
| CN102302686A (en) * | 2011-07-22 | 2012-01-04 | 陈超 | Medicament for treating xerophthalmia |
Non-Patent Citations (1)
| Title |
|---|
| 冉国侠: "《化妆品评价方法》", 31 May 2011, 中国纺织出版社 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038700A (en) * | 2014-04-18 | 2016-10-26 | 温先敏 | Application of butterflybush flower and extract in preparation of medicine for treating pulmonary heart disease |
| CN106038701A (en) * | 2014-04-18 | 2016-10-26 | 温先敏 | Application of Flos Buddlejae and extract thereof in preparation of cardiac tumor disease treatment medicines |
| CN106109580A (en) * | 2014-04-18 | 2016-11-16 | 温先敏 | Flos Buddlejae and extract thereof treat the application of myocardiac medicine as preparation |
| CN104055722A (en) * | 2014-06-13 | 2014-09-24 | 昆明密姿娜贸易有限公司 | Preparation method of plant hair-care mixture |
| CN104957594A (en) * | 2015-06-29 | 2015-10-07 | 梁海林 | Preparation method of buddleja officinalis concentrated liquid |
| CN105011114A (en) * | 2015-06-29 | 2015-11-04 | 梁海林 | Preparation method of maple leaf concentrated solution |
| CN105891380A (en) * | 2016-04-22 | 2016-08-24 | 广西壮族自治区梧州食品药品检验所 | Method using ASE method to extract linarin in buddleja officinalis |
| CN110917104A (en) * | 2019-12-12 | 2020-03-27 | 乐芸 | Common tower hair nourishing cream and preparation method thereof |
| CN111568910A (en) * | 2020-07-06 | 2020-08-25 | 上海沸米生物科技有限公司 | Application of crocin II in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissues |
| CN111568910B (en) * | 2020-07-06 | 2021-06-01 | 上海沸米生物科技有限公司 | Application of crocin II in preparation of medicine for preventing and treating alopecia by acting on hair follicle tissues |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100893106B1 (en) | Composition for hair growth | |
| CN102657703A (en) | New application of traditional Chinese medicine buddleja officinalis | |
| CN102988264A (en) | Ginkgo leaf freckle removing whitening cream and preparation method thereof | |
| CN106035861A (en) | Inonotus obliquus substitutional tea with health-care functions and preparation method thereof | |
| CN103041309A (en) | Beauty folium ginkgo oral liquid and preparation method thereof | |
| CN105496917A (en) | Herba centellae anti-wrinkling face cream and preparation method thereof | |
| CN102657791A (en) | Chinese medicinal composition containing pale butterflybush flower and preparation method thereof | |
| CN110624089A (en) | A topical Chinese medicinal composition for promoting hair growth, and its preparation method | |
| CN106333010A (en) | Bagged weight-losing and slimming tea and making method thereof | |
| JP2011195502A (en) | Fibroblast proliferation promoter, anti-ageing agent and wrinkle-ameliorating agent | |
| CN106343091A (en) | Weight-loss herbal tea beverage and preparation method thereof | |
| CN102133167B (en) | Freckle removing facial mask made of traditional Chinese medicine and preparation process thereof | |
| CN104473153B (en) | A kind of Fructus Mori oral liquid of looks improving and the skin nourishing and preparation method thereof | |
| CN103877135A (en) | New application of traditional Chinese medicine notoginseng flower | |
| CN106138591A (en) | Containing Fructus Lycii and the maca composition of Qi-tonifying drug | |
| CN102266427A (en) | Cartialgenous and angelica wine for maintaining beauty and keeping young as well as preparation method and application thereof | |
| CN105616984A (en) | Crinkle-removing beauty cream containing herba leonurus and preparation method thereof | |
| CN105663700A (en) | Wrinkle resistance and beauty treatment cream making method and beauty treatment cream thereof | |
| CN108686107B (en) | Chinese herbal medicine composition for promoting hair volume increase, its preparation method and use | |
| CN110897119A (en) | Composition for improving sleep quality | |
| CN105362663A (en) | Traditional Chinese medicine preparation for treating juvenile poliosis | |
| CN104524479A (en) | Traditional Chinese medicine composition for treating premenstrual syndrome and preparation method of traditional Chinese medicine composition | |
| CN105560984B (en) | Traditional Chinese medicine composition capable of boosting qi and invigorating spleen | |
| CN103381202A (en) | Skin whitening traditional Chinese medicine composition and use thereof | |
| KR102440888B1 (en) | Percutaneous nutrient composition using and manufacturing method whichof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20120912 |