CN102539806A - Multi-channel liquid sampling equivalent distancing device - Google Patents

Abstract

The invention relates to a multi-channel liquid sampling equidistant distance division device, which includes a distance division motor, a distance division screw, a guide rail, a number of sampling needles corresponding to each channel, and a guide slider. The guide slider is provided with The screw thread matched with the spacing lead screw, the said spacing screw is provided with a 2m segment thread with the number of segments equal to the number of channels, in which the screw threads of the left half and the right half of the spacing screw are opposite in direction, from outside to inside The pitch ratio of each thread is 2m-1:2m-3...:1. The distance-dividing motor drives the distance-dividing screw to rotate through the coupling, and then drives the corresponding displacement of each guide slider along the guide rail to realize equal adjustment of channel spacing and ensure that the distance between channels is always the same. The present invention utilizes a pitch-dividing lead screw with variable pitch and direction of rotation to realize equal and simultaneous adjustment of the distances of the sampling needles in each channel. ,reliable.

Description

A multi-channel liquid sampling equidistant dividing device

technical field

The invention relates to a liquid sampling mechanism, in particular to a multi-channel liquid sampling equidistant spacing device which utilizes one degree of freedom to realize equal adjustment of all channel spacings.

Background technique

As we all know, the liquid sampling mechanism can be widely used in molecular biology experiments, immunoassays, gene sequencing, biochemical analysis and other industries. In molecular biology research, it is often necessary to compare the experimental results of different parameters, so as to obtain Statistically significant results; on the other hand, immunoassays have higher and higher requirements for speed, so the industry urgently needs a high-throughput multi-channel liquid sampling mechanism. However, in different liquid processing processes, the hole spacing of the liquid container is different, and the channel spacing needs to be adjusted. Therefore, the multi-channel sampling mechanism should also have the ability to adjust the channel spacing. At present, the existing liquid sampling mechanism needs multiple movements to complete the adjustment of the channel spacing, and the mechanism is relatively complicated.

Contents of the invention

The technical problem to be solved by the present invention is to overcome the deficiencies of the above-mentioned prior art, provide a reasonable structure, the sampling needles of each channel can move independently in the vertical direction, and the equidistant adjustment between all channels can be completed through one degree of freedom. The power transmission is simple and reliable, and the multi-channel liquid sampling equidistant distance device.

The technical solution adopted by the present invention to solve the above-mentioned technical problems is: a multi-channel liquid sampling equal-distance dividing device, which is characterized in that it includes a distance-dividing motor, a distance-dividing screw, guide rails, and several sampling needles corresponding to each channel. and a guide slider, the guide slider is provided with threads that cooperate with the spacing lead screw, the guide slider is installed on the guide rail, and can move along the guide rail; the 2m segment thread is provided on the described distance guide screw ( m is a natural number), the number of thread segments is equal to the number of channels, in which the left half and the right half of the spacer screw have m sections of thread, and the screw threads of the left half and right half of the spacer screw are opposite, from outside to The pitch ratio of each section of thread in the interior is 2m-1:2m-3...:1; the thread on the guide slider corresponding to each channel cooperates with a section of thread on the distance-dividing screw for transmission, and the distance-dividing motor passes through The coupling drives the spacing lead screw to rotate, and then drives the guide sliders to make corresponding displacements along the guide rail, so as to realize the equal adjustment of the channel spacing and ensure that the distance between the channels is always the same.

The thread on the guide slider of the present invention is an internal thread, and the internal thread cooperates with a corresponding segment of the thread on the distance-dividing screw for transmission. The guide slider is also provided with guide holes that match the sample needle up and down. The sample needle can move up and down along the hole.

The sampling needles of each channel in the present invention are driven up and down by a lifting mechanism, and the lifting mechanism includes a lifting motor, a gear, a lifting rack, and a connecting block for the sampling needle. The gear is installed on the shaft of the lifting motor, and the lifting rack is vertical. Installed on the connecting block of the sampling needle, the sampling needle is fixedly connected with the connecting block of the sampling needle, the lifting motor drives the gear to rotate, and then drives the lifting rack meshed with the gear to move up and down, and then drives the sampling needle through the connecting block of the sampling needle Move up and down along the guide slider to realize the independent up and down movement of each sample needle. the

The thickness of the gear of the present invention is 10-15mm more than the width of the elevating rack. The thickness of the gear is wider than that of the lifting rack, which can ensure that the lifting rack is always meshed with the gear during the channel spacing adjustment process, so as to ensure that each channel can move independently after the distance is adjusted.

The present invention adopts the above-mentioned structure, and utilizes a variable-pitch and variable-rotation spacing lead screw to realize the equal and simultaneous adjustment of the distances of the sampling needles in each channel, driven by only one spacing motor, so that the channel spacing adjustment mechanism becomes simple; Each channel is driven by its own lifting motor to realize the up and down movement of the sample needle, thus ensuring the independence of the up and down movement of each channel. Compared with the prior art, the structure of the present invention is reasonable, the sampling needles of each channel can move independently in the vertical direction, the equidistant adjustment between all channels can be completed through one degree of freedom, and the motion transmission is simple and reliable. Channel liquid sampling equidistant interval device.

Description of drawings

The present invention will be further described below in conjunction with the accompanying drawings.

FIG. 1 is a schematic diagram of a composition structure of the present invention.

Fig. 2 is a schematic diagram of a spacing lead screw of the present invention.

Fig. 3 is a schematic diagram of the elevating mechanism of the sampling needle of the present invention.

Fig. 4 is a schematic diagram of an application state of the present invention.

Labels in the figure: 11. Distance motor, 12. Coupling, 13. Guide rail, 14. Support frame, 151. Sample needle, 152. Sample needle, 153. Sample needle, 154. Sample needle, 16 .Spacing lead screw, 171. Guide slider, 172. Guide slider, 173. Guide slider, 174. Guide slider, 21. Sample needle connection block, 22. Lifting rack, 23. Lifting motor, 24 .Gear, 25.Worktable support plate, 31.X direction screw, 32.X direction motor, 33.Y direction motor, 34.Test tube rack, 35.X direction guide rail, 36.Y direction guide rail, 37.Y direction Lead screw, 38. test tube rack.

Detailed ways

It can be seen from Fig. 1 that a multi-channel liquid sampling equidistant interval device is for four-channel liquid sampling. It includes a spacing motor 11, a spacing screw 16, a guide rail 13, a number of sampling needles 151, 152, 153, 154 corresponding to each channel, and guide sliders 171, 172, 173, 174. The spacing motor 11 passes through the shaft coupling. Device 12 is connected with distance leading screw 16. The distance-dividing motor 11 is installed on the workbench support plate by a support frame 14. Guide rail 13 is also installed on the workbench support plate by bracket.

The guide sliders 171, 172, 173, 174 are provided with guide holes cooperating with the corresponding sampling needles 151, 152, 153, 154. Each sampling needle passes through the corresponding guide holes, and the sampling needles can be moved along the The hole moves up and down. The guide sliders 171 , 172 , 173 , 174 are provided with threads that cooperate with the spacing lead screw 16 , and the guide sliders 171 , 172 , 173 , 174 are installed on the guide rail 13 and can move along the guide rail 13 .

The distance-dividing screw 16 is provided with 2m sections of threads (m is a natural number, such as 2, 3, 4, 5), and the number of thread segments is equal to the number of channels, wherein the left half and the right half of the spacing screw each have m Sectional thread, the thread direction of the left half and the right half of the pitch screw 16 is opposite, and the pitch ratio of the left half and the right half of the pitch screw 16 from the outside to the inside is the same, all of which are 2m-1 :2m-3...:1.

FIG. 2 is a schematic diagram of a 4-channel liquid sampling feed screw. There are 4 sections of thread in the whole pitch screw, two sections in the left half and two sections in the right half. The left and right halves of the spacer screw have opposite threads. The pitch ratio of the two sections of threads from the outside to the inside of the left half and the right half of the pitch screw is 3:1.

According to the present invention, the thread on the guide slider corresponding to each channel cooperates with a section of thread on the distance-dividing lead screw 16, and the distance-dividing motor 11 drives the distance-dividing lead screw 16 to rotate through the coupling 12, and then drives each guide The sliders are displaced correspondingly along the guide rails, and the guide sliders 171, 172, 173, 174 respectively drive the sample needles 151, 152, 153, 154 to move along the guide rail 13. The speed ratio of the sample needle 151 to the sample needle 152 3:1, the ratio of the speed of sample needle 154 to sample needle 153 is also 3:1, but the speed direction of 151, 152 is opposite to that of 153, 154. In this way, the sampling needle will produce different directions and speeds according to the different helical directions and pitches, that is, to realize equidistant separation, realize equal adjustment of channel spacing, and ensure that the distance between channels is always the same.

For 6-channel liquid sampling, there are 6 sections of threads in the spaced screw, three sections in the left half and three sections in the right half. The left and right halves of the spacer screw have opposite threads. The pitch ratio of the three sections of thread from the outside to the inside of the left half and the right half of the pitch screw is 5:3:1.

For liquid sampling in 8-channel channel, there are 8 sections of screw threads in total, 4 sections in the left half and 4 sections in the right half. The left and right halves of the spacer screw have opposite threads. The pitch ratio of the four-segment threads from outside to inside of the left half and right half of the pitch screw is 7:5:3:1.

The screw threads on the guide sliders 171, 172, 173, 174 of the present invention are internal threads, and the internal threads cooperate with a section of the corresponding screw thread on the described spacing lead screw 16 for transmission. The guide hole for the sample needle, the sample needle can move up and down along the hole.

The sampling needles of each channel in the present invention are driven up and down by a lifting mechanism. As shown in Figure 3, the lifting mechanism includes a lifting motor 23, a gear 24, a lifting rack 22, and a sample needle connection block 21. The gear 24 is installed on the shaft of the lifting motor 23 through a reduction mechanism, and the lifting rack 22 is installed vertically on the shaft of the lifting motor 23. On the sample needle connection block 21, the sample needle 154 is fixedly connected with the sample needle connection block 21. In this way, the lifting rack 22 and the sample needle 154 are fixed together by the sample needle connection block 21, so the lift rack 22 The movement drives the movement of the sample needle 154 . Whole elevating mechanism is installed on the workbench support plate 25. The lifting motor 23 drives the gear 24 to rotate, and then drives the lifting rack 22 meshed with the gear to move up and down, and then drives the sample needle 154 to move up and down along the guide slider 174 through the sample needle connection block 21, so as to realize the independent movement of each sample needle. Moving up and down. In the multi-channel sampling device, the sampling needles of each channel are driven up and down by an elevating mechanism, and the movement of each sampling needle is independent of each other, so that it is suitable for adding samples to test tubes with different liquid level heights.

The gear 24 of the present invention is designed to be 10-15mm wider than the lifting rack 22, which can ensure that the lifting rack slides along the axial direction of the gear during the equal separation process of the channel spacing, and is always meshed with the gear, thereby ensuring that each channel after distance adjustment Can move alone. In this way, not only the independent movement of each sample needle in the vertical direction is realized, but also the single-degree-of-freedom control of the equidistant separation of the sample needles is realized. Here, the length of the lifting rack 22 in the horizontal direction is defined as the width of the lifting rack, and the height of the lifting rack 22 in the vertical direction is defined as the length of the lifting rack. The length of the lifting rack determines the lifting range of the sampling needle.

The structural forms and components used in each channel lifting mechanism of the present invention are the same, but they are placed on both sides of the guide rails according to the number of channels and limited by the structure.

Fig. 4 is a schematic diagram of an application state of the present invention. Define the equal interval direction as the Y direction, the lifting direction of the sample needle as the Z direction, and the direction perpendicular to the equal interval direction as the X direction. In the X direction, the X direction motor 32 drags the X direction screw 31 to rotate, and then drives the entire sliding support frame to move along the X direction guide rail 35. When the sliding support frame reaches a given position, the motor stops and the sliding support The frame also stops moving, which increases the working space of the sample needle in the X direction; in the Y direction, the Y direction motor 33 drags the Y direction screw 37 to rotate, and then drives the support frame to move along the Y direction guide rail 36 to reach a certain level. At a given position, the movement is stopped, which increases the working space of the sample needle in the Y direction. Meet the different sample loading requirements of the test tube rack 34 and the test tube rack 38.

In the Z direction, the lifting motor 23 drives the lifting gear 24 to rotate. Through the meshing relationship between the gear and the lifting rack, the lifting rack 22 is driven to move up and down in the Z direction. The sample needle drives the sample needle to move in the Z direction. For the multi-channel sampling device, each lifting motor can only drive one sampling needle, so that the movement of each sampling needle is independent of each other.

For the working process of the multi-channel liquid sampling device with equal intervals, the four-channel equal intervals are used to illustrate. The sampling needle can reach a given position in the space according to the above description, but for adding samples to the test tube racks 34 and 38 of different specifications, it is necessary to constantly adjust the distance between the sampling needles. As shown in Figure 4, when working above the test tube rack 34 with a spacing of 10 mm, it is necessary to adjust the spacing of the sampling needles to be 10 mm, and when working above the test tube rack 38 with a spacing of 15 mm, the spacing of the sampling needles becomes 15 mm. The needles are equidistantly separated. After working on the top of the 10mm test tube rack, the distance-dividing motor starts to rotate, and the screw is driven to rotate through the coupling. 151 and 152 and the sampling needles 153 and 154 move in the same direction at a speed of 3:1 respectively, so that equidistant separation of the sampling needles is realized. the

Claims (4)

1. a hyperchannel liquid application of sample equivalent is divided apart from device; It is characterized in that: it comprise branch apart from motor, divide sample needle and guide runner apart from leading screw, guide rail, some each passages of correspondence; Said guide runner is provided with and divides the screw thread that cooperates apart from leading screw; Guide runner is installed on the said guide rail, can move along guide rail; Said branch is provided with 2m section screw thread (m is a natural number) apart from leading screw; The screw thread hop count equates with port number; Wherein divide apart from leading screw left-half and right half part m section screw thread is respectively arranged; Branch is opposite apart from the thread rotary orientation of leading screw left-half and right half part, and the pitch ratio of each section screw thread is 2m-1:2m-3 from outside to inside ...: 1; The one section threaded engagement transmission on the leading screw of screw thread on the guide runner of said each passage of correspondence and said branch; Divide apart from motor and rotate apart from leading screw through shaft coupling drive branch; And then drive each guide runner and carry out corresponding displacement along guide rail; Realize the adjusting of channel pitch equivalent, guarantee that the distance between each passage is identical all the time.

2. hyperchannel liquid application of sample equivalent according to claim 1 is divided apart from device; It is characterized in that: the screw thread on the said guide runner is an internal thread; The one section corresponding threaded engagement transmission on the leading screw of internal thread and said branch; Have the pilot hole that cooperates with sample needle on also on the guide runner, sample needle can move up and down along this hole.

3. hyperchannel liquid application of sample equivalent according to claim 1 is divided apart from device; It is characterized in that: each is driven the sample needle of said each passage by an elevating mechanism, and said elevating mechanism comprises lifting motor, gear, lifter rack, sample needle contiguous block, and gear is installed on the lifting motor axle through reducing gear; Lifter rack is vertically mounted on the sample needle contiguous block; Sample needle is fixedly connected with the sample needle contiguous block, and the lifting motor driven gear rotates, and then the lifter rack of drive and gearing mesh moves up and down; Drive sample needle through the sample needle contiguous block again and move up and down, realize independently moving up and down of each sample needle along guide runner.

4. hyperchannel liquid application of sample equivalent according to claim 3 is divided apart from device, it is characterized in that: the thickness of said gear manys 10-15mm than the width of lifter rack.

Images