CN102457252A - double-channel pulse generator and implantable electrical stimulation system - Google Patents

Abstract

The invention discloses a dual-channel pulse generator which comprises a microprocessor module and a dual-channel electrical stimulation circuit module, wherein the microprocessor module is used for receiving a regulation and control command sent by an external program controller and transmitting the regulation and control command to the electrical stimulation circuit module, and the electrical stimulation circuit module comprises a first stimulation pulse output channel and a second stimulation pulse output channel which can be respectively and independently regulated and controlled to output. Compared with the prior art, the electrical stimulation digital-analog hybrid chip can process the regulation and control command sent by the external program controller, and realizes independent regulation and control output through the first stimulation pulse output channel and the second stimulation pulse output channel respectively, so that a doctor can independently regulate and control the stimulation output of the two channels of the dual-channel pulse generator, such as frequency, pulse width, amplitude, stimulation mode and the like, and the nerve regulation and control of the left side and the right side of the brain of a patient can achieve the optimal effect.

Description

Dual-channel pulse generator and implantable electrical stimulation system

technical field

The invention relates to an implantable medical device, in particular to a pulse generator with dual-channel independently adjustable output and an implantable electrical stimulation system.

Background technique

In the prior art, implantable electrical stimulation systems and implantable drug delivery systems have been used more and more widely as a means of treating or preventing diseases. Implantable electrical stimulation systems usually include implantable cardiac electrical stimulation systems (commonly known as cardiac pacemakers) and implantable nerve electrical stimulation systems, mainly including implanted pulse generators, electrodes and external control devices. Among them, the pulse generator is connected to the electrode, so that the pulse generated by the pulse generator is transmitted to the electrode, and the pulse signal generated by the pulse generator is transmitted from the electrode to the heart or specific nerve parts for electrical stimulation, so that the human body function returns to normal state of operation.

Known implantable electrical nerve stimulation systems generally mainly include pulse generators, electrodes, extension leads, and external control devices. Wherein, the pulse generator is connected to the extension wire, and the extension wire is further connected to the electrode, so that the pulse generated by the pulse generator is transmitted to the electrode to electrically stimulate the nerve.

The implantable dual-channel pulse generator means that the pulse generator has two stimulation outputs to stimulate the left and right sides of the brain respectively to achieve therapeutic effects. The stimulation frequency of the two channels of the dual-channel pulse generator in the prior art must be the same and cannot be adjusted separately. Studies have shown that the effect of using the same frequency stimulation mode on the left and right sides of the brain is not ideal. Therefore, how to realize all the functions of the dual-channel pulse generator Stimulation parameters (including frequency, pulse width, amplitude and stimulation mode) can be independently adjusted and controlled, so that the optimal effect of neural regulation on the left and right sides of the brain is an urgent problem to be solved.

Contents of the invention

In view of the deficiencies in the prior art, the technical problem to be solved by the present invention is to provide a dual-channel pulse generator and an implantable electrical stimulation system capable of independently adjusting and controlling the two channels of the pulse generator.

According to the technical solution provided by the present invention, a dual-channel pulse generator includes a microprocessor module and a dual-channel electrical stimulation circuit module. The electrical stimulation circuit module includes a first stimulation pulse output channel and a second stimulation pulse output channel that can independently regulate the output.

Preferably, the dual-channel electrical stimulation circuit module is a dual-channel electrical stimulation digital-analog hybrid chip.

Preferably, the independently adjustable outputs include frequency, pulse width, amplitude and stimulation mode of stimulation pulses.

Preferably, the microprocessor module includes a CPU, a memory, and a first communication module;

The electrical stimulation digital-analog hybrid chip includes a second communication module connected to the first communication module through a communication bus;

The first stimulation pulse output channel includes a first channel register storage module, a first channel digital pulse generator, a first channel analog pulse generator, and a first channel output control module sequentially connected to the second communication module;

The second stimulation pulse output channel includes a second channel register storage module, a second channel digital pulse generator, a second channel analog pulse generator, and a second channel output control module that are sequentially connected to the second communication module.

Preferably, the electric stimulation digital-analog hybrid chip includes a digital circuit module for generating an independently adjustable digital stimulation regulation signal output and an analog circuit module for converting the digital stimulation regulation signal into an analog stimulation signal output;

The digital circuit module includes the second communication module, a first channel register storage module and a second channel register storage module connected to the second communication module, and a channel register storage module connected to the first channel register storage module. The first channel digital pulse generator for generating the specified frequency, pulse width, amplitude and stimulation mode of the first channel is connected with the second channel register storage module for generating the specified frequency, pulse width and amplitude of the second channel and a second channel digital pulse generator in stimulation mode;

The analog circuit module includes a first channel analog pulse generator connected to the first channel digital pulse generator, a second channel analog pulse generator connected to the second channel digital pulse generator, and the A first channel output control module connected to the first channel analog pulse generator, and a second channel output control module connected to the second channel analog pulse generator.

Preferably, the designated stimulation mode is one of continuous stimulation mode, burst stimulation mode, timed stimulation mode, motion stimulation mode and soft stimulation mode.

The present invention provides an implantable electrical nerve stimulation system comprising the above-mentioned dual-channel pulse generator.

Preferably, the implanted electrical nerve stimulation system is an implanted deep brain electrical stimulation system, an implanted cortical electrical stimulation system, an implanted spinal cord electrical stimulation system, an implanted sacral nerve electrical stimulation system or an implanted One of the electrical vagus nerve stimulation systems.

The present invention also provides an implantable cardiac pacing system and an implantable cardioverter-defibrillation system, comprising the above-mentioned dual-channel pulse generator, capable of independently adjusting and controlling the two channels of the pulse generator.

Compared with the prior art, the advantages of the present invention are: since the electrical stimulation digital-analog hybrid chip of the present invention includes a first stimulation pulse output channel and a second stimulation pulse output channel that can independently regulate the output, the electrical stimulation digital-analog hybrid chip It can process the control commands sent by the in vitro program controller, realize independent control output through the first stimulation pulse output channel and the second stimulation pulse output channel, and realize that the doctor can stimulate the output of the two channels of the dual-channel pulse generator (Frequency, pulse width, amplitude and stimulation mode) can be adjusted independently, so that the neural regulation on the left and right sides of the patient's brain can achieve the best effect.

Description of drawings

Accompanying drawing 1 is the module schematic diagram of the present invention;

Accompanying drawing 2 is the module schematic diagram of pulse generator of the present invention;

Accompanying drawing 3 is the modular schematic diagram of the microprocessor chip and the electrical stimulation digital-analog hybrid chip of the present invention.

in:

1. Pulse generator; 11. Microprocessor chip; 111. First communication module; 12. Electric stimulation digital-analog hybrid chip; 121. Second communication module; 122. First channel register storage module; 123. First channel Digital pulse generator; 124, first channel analog pulse generator; 125, first channel output control module; 126, second channel register storage module; 127, second channel digital pulse generator; 128, second channel analog pulse Generator; 129, second channel output control module; 13, wireless communication module; 14, power supply; 15, first stimulation pulse output channel; 16, second stimulation pulse output channel; 17, digital circuit module; 18, analog circuit module; 2. electrode; 3. external program controller.

Detailed ways

Below in conjunction with accompanying drawing, the present invention is described in further detail:

Referring to FIG. 1 , a two-channel independently adjustable implantable electrical nerve stimulation system includes a pulse generator 1 , electrodes 2 , and an external programmer 3 implanted in a patient. The pulse generator 1 is electrically connected to the electrode 2, so that the pulse generated by the pulse generator 1 is transmitted to the electrode 2, so as to electrically stimulate the nerve target to achieve a therapeutic effect. The in vitro programmer 3 can communicate with the pulse generator 1 through an electromagnetic coil or a wireless communication module, so as to adjust various output parameters of the pulse generator 1 .

Referring to Figure 2, taking the dual-channel independently adjustable implantable deep brain electrical stimulation system as an example, it includes a dual-channel pulse generator 1 implanted in the patient's sternocostal subcutaneous tissue, and a pulse generator implanted deep in the brain. 1 connected to the electrode 2, the pulse generator 1 includes a microprocessor module, an electric stimulation circuit module connected with the microprocessor module, a wireless communication module 13 and a power supply 14 for supplying power to the above modules.

The microprocessor module is used to receive the control commands issued by the in vitro program controller and send them to the electrical stimulation circuit module, which includes the first stimulation pulse output channel 15 and the second stimulation pulse output channel 15 which can independently control the output respectively. Pulse output channel 16. In this embodiment, the microprocessor module is a microprocessor chip 11 , and the dual-channel electrical stimulation circuit module is a dual-channel electrical stimulation digital-analog hybrid chip 12 .

The output that can be independently adjusted by the first stimulation pulse output channel 15 and the second stimulation pulse output channel 16 includes the frequency, pulse width, amplitude and stimulation mode of the stimulation pulse. The output parameters of the first stimulation pulse output channel 15 and the second stimulation pulse output channel 16 may be completely the same or different.

With reference to Fig. 3, described microprocessor module comprises CPU, memory, first communication module 111, and described electrical stimulation digital-analog hybrid chip 12 comprises the second communication module that is connected with described first communication module 111 by communication bus 121.

The first stimulation pulse output channel 15 includes a first channel register storage module 122 sequentially connected to the second communication module 121, a first channel digital pulse generator 123, a first channel analog pulse generator 124, a first channel Channel output control module 125 .

The second stimulation pulse output channel 16 includes a second channel register storage module 126 connected in sequence with the second communication module 121, a second channel digital pulse generator 127, a second channel analog pulse generator 128, a second channel Channel output control module 129 .

In this embodiment, the first communication module 111 is an SPI sending module, and the second communication module 121 is an SPI receiving module. The SPI sending module and the SPI receiving module are connected through the SPI bus for serial two-way communication. In other embodiments, other bus communication methods can be used to realize the communication between the microprocessor chip 11 and the electrical stimulation digital-analog hybrid chip 12 .

The electric stimulation digital-analog hybrid chip 12 includes a digital circuit module 17 for generating an independently adjustable digital stimulation regulation signal output and an analog circuit module 18 for converting the digital stimulation regulation signal into an analog stimulation signal output.

The digital circuit module 17 includes the second communication module 121, the first channel register storage module 122 and the second channel register storage module 126 connected with the second communication module 121, and the first channel register storage module 126 connected with the second communication module 121. The storage module 122 is connected to the first channel digital pulse generator 123 for generating the specified frequency, pulse width, amplitude and stimulation mode of the first channel, and is connected to the second channel register storage module 126 for generating the second channel A second channel digital pulse generator 127 specifying frequency, pulse width, amplitude and stimulation mode;

Described analog circuit module 18 comprises the first channel analog pulse generator 124 that is connected with described first channel digital pulse generator 123, the second channel analog pulse generator that is connected with described second channel digital pulse generator 127 128 , a first channel output control module 125 connected to the first channel analog pulse generator 124 , and a second channel output control module 129 connected to the second channel analog pulse generator 128 .

The designated stimulation mode is one of continuous stimulation mode, burst stimulation mode, timing stimulation mode, motion stimulation mode and soft stimulation mode. The timing stimulation mode refers to the opening and closing state of the existing stimulation program in the neural stimulator that can be cycled within the time interval set by the program. The soft stimulation mode refers to the ability to soft open and soft stop, that is, when the stimulation is turned on, pulses are allowed The amplitude is slowly ramped up to the programmed allowable value, and the pulse amplitude is allowed to slowly decrease to 0 when the stimulus is turned off.

The present invention provides an implantable electrical nerve stimulation system comprising the above-mentioned double-channel independently adjustable pulse generator. According to different diseases to be treated, the implanted electrical nerve stimulation system can be implanted deep brain electrical stimulation system, implanted cerebral cortex electrical stimulation system, implanted spinal cord electrical stimulation system, implanted sacral nerve electrical stimulation system Or one of the Implantable Vagus Nerve Stimulation Systems.

The present invention also provides an implantable cardiac pacing system and an implantable cardioverter-defibrillation system, comprising the above-mentioned dual-channel pulse generator, capable of independently adjusting and controlling the two channels of the pulse generator.

Using the dual-channel pulse generator of the present invention that can independently adjust the control output, the doctor can input the regulation command into the microprocessor chip 11 through the wireless communication module 13 through the external program controller for processing, and the first communication module 111 enters the second through the SPI bus. The second communication module 121 is then stored in the first channel register storage module 122 and the second channel register storage module 126 respectively.

The first channel register storage module 122 transmits the first channel control command to the first channel digital pulse generator 123 for generating an independently adjustable digital stimulus control signal output, and the first channel digital pulse generator 123 transmits the digital stimulus control signal The first channel analog pulse generator 124 is converted into an analog stimulation signal, and the first channel analog pulse generator 124 transmits the analog stimulation signal to the first channel output control module 125 to output stimulation.

Similarly, the second channel register storage module 126 transmits the second channel control command to the second channel digital pulse generator 127 for generating an independently adjustable digital stimulus control signal output, and the second channel digital pulse generator 127 outputs the digital stimulus The control signal is sent to the second channel analog pulse generator 128 for conversion into an analog stimulation signal, and the second channel analog pulse generator 128 sends the analog stimulation signal to the second channel output control module 129 to output stimulation.

Compared with the prior art, the electrical stimulation digital-analog hybrid chip 12 of the present invention includes a first stimulation pulse output channel 15 and a second stimulation pulse output channel 16 that can independently regulate the output, so that the electrical stimulation digital-analog hybrid chip 12 can The control commands sent by the in vitro program controller are processed, and the independent control output is realized through the first stimulation pulse output channel 15 and the second stimulation pulse output channel 16 respectively, so that the doctor can adjust the frequency, frequency and frequency of the two channels of the dual-channel pulse generator. Stimulation output such as pulse width, amplitude and stimulation mode can be independently adjusted, so that the neural regulation on the left and right sides of the patient's brain can achieve the best effect.

The present invention also can have other various embodiments, without departing from the spirit and essence of the present invention, those skilled in the art can make various corresponding changes and deformations according to the present invention, but these corresponding changes and deformations should be Belong to the protection scope of the claims of the present invention.

Claims (10)

1. binary channels pulse generator; It is characterized in that: comprise microprocessor module and binary channels electrical stimulation circuit module; Said microprocessor module is used to receive the regulation and control order that vitro program controlled device sends and sends said electrical stimulation circuit module to, and said electrical stimulation circuit module comprises the first boost pulse output channel and the second boost pulse output channel that can distinguish independent regulation and control output.

2. binary channels pulse generator according to claim 1 is characterized in that: said binary channels electrical stimulation circuit module is a binary channels electrostimulation digital-to-analogue hybrid chip.

3. binary channels pulse generator according to claim 2 is characterized in that: the said regulation and control of independence respectively output comprises frequency, pulsewidth, amplitude, the stimulus modality of boost pulse.

4. according to claim 2 or 3 described binary channels pulse generators, it is characterized in that: described microprocessor module comprises CPU, memory, first communication module;

Said electrostimulation digital-to-analogue hybrid chip comprises second communication module that is connected with said first communication module through communication bus;

The said first boost pulse output channel comprises first passage register-stored module, first passage digital pulse generator, first passage mimic pulse generator, the first passage output control module that is connected successively with said second communication module;

The said second boost pulse output channel comprises second channel register-stored module, second channel digital pulse generator, second channel mimic pulse generator, the second channel output control module that is connected successively with said second communication module.

5. binary channels pulse generator according to claim 4 is characterized in that:

Said electrostimulation digital-to-analogue hybrid chip comprises that being used to produce independent regulatable numeral stimulates the digital circuit blocks of adjustment signal output to stimulate adjustment signal to convert the analog module of simulation stimulus signal output into above-mentioned numeral with being used for;

Said digital circuit blocks comprises described second communication module; First passage register-stored module that is connected with said second communication module and second channel register-stored module; Be connected with said first passage register-stored module and be used to produce the first passage assigned frequency; Pulsewidth; The first passage digital pulse generator of amplitude and stimulus modality; Be connected with said second channel register-stored module and be used to produce the second channel assigned frequency; Pulsewidth; The second channel digital pulse generator of amplitude and stimulus modality;

Said analog module comprises the first passage mimic pulse generator that is connected with said first passage digital pulse generator, the second channel mimic pulse generator that is connected with said second channel digital pulse generator, the first passage output control module that is connected with said first passage mimic pulse generator, the second channel output control module that is connected with said second channel mimic pulse generator.

6. binary channels pulse generator according to claim 5 is characterized in that: the stimulus modality of described appointment is the continued stimulus pattern, bunch send out stimulus modality, a kind of in stimulus modality, motion stimulus modality, the soft stimulus modality regularly.

7. an implantable nerve electric stimulation is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.

8. implantable nerve electric stimulation according to claim 7 is characterized in that: said implantable nerve electric stimulation is a kind of in implanted brain deep electric stimulation, implanted cortex electric stimulation, implanted spinal cord stimulation trial system, implanted sacral nerve electric stimulation or the implanted vagus nerve electric stimulation.

9. an implantable cardiac pacing system is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.

10. an implantable cardiac conversion defibrillation system is characterized in that: comprise arbitrary described binary channels pulse generator in the claim 1 to 6.

Images