CN102406960A - Preparation method of neomycin medical dressing - Google Patents
Preparation method of neomycin medical dressing Download PDFInfo
- Publication number
- CN102406960A CN102406960A CN2011103930776A CN201110393077A CN102406960A CN 102406960 A CN102406960 A CN 102406960A CN 2011103930776 A CN2011103930776 A CN 2011103930776A CN 201110393077 A CN201110393077 A CN 201110393077A CN 102406960 A CN102406960 A CN 102406960A
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- CN
- China
- Prior art keywords
- component
- neomycin
- medical
- grams
- stirring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229930193140 Neomycin Natural products 0.000 title claims abstract description 28
- 229960004927 neomycin Drugs 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title abstract 2
- 238000003756 stirring Methods 0.000 claims abstract description 26
- 238000002156 mixing Methods 0.000 claims abstract description 18
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims abstract description 17
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 15
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 15
- 239000000648 calcium alginate Substances 0.000 claims abstract description 15
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 15
- 239000000203 mixture Substances 0.000 claims abstract description 13
- 239000000835 fiber Substances 0.000 claims abstract description 11
- 239000004745 nonwoven fabric Substances 0.000 claims abstract description 10
- 239000012567 medical material Substances 0.000 claims abstract description 7
- AXTGDCSMTYGJND-UHFFFAOYSA-N 1-dodecylazepan-2-one Chemical compound CCCCCCCCCCCCN1CCCCCC1=O AXTGDCSMTYGJND-UHFFFAOYSA-N 0.000 claims abstract description 6
- 239000012188 paraffin wax Substances 0.000 claims abstract description 6
- 239000000843 powder Substances 0.000 claims abstract description 6
- 229940099259 vaseline Drugs 0.000 claims abstract description 6
- 238000007765 extrusion coating Methods 0.000 claims abstract description 4
- 238000000034 method Methods 0.000 claims description 15
- 239000004744 fabric Substances 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
- 229920001661 Chitosan Polymers 0.000 claims description 3
- 229920000297 Rayon Polymers 0.000 claims description 3
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- 239000006185 dispersion Substances 0.000 claims description 3
- 239000000463 material Substances 0.000 claims description 3
- 239000004033 plastic Substances 0.000 claims description 3
- 229920003023 plastic Polymers 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 abstract 1
- 238000000576 coating method Methods 0.000 abstract 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 6
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 230000000694 effects Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010048038 Wound infection Diseases 0.000 description 1
- 239000003242 anti bacterial agent Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- Medicinal Preparation (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a preparation method of neomycin medical dressing, 1, taking 1000 g of calcium alginate fiber, crushing the calcium alginate fiber into powder of 200 meshes to 500 meshes, and then taking 6 g to 10 g of neomycin and calcium alginate fiber powder to be uniformly mixed for later use, wherein the component A is a component; 2. taking 50-80 g of glycol and 120 g of water-soluble azone, and uniformly mixing for later use to obtain a component B; 3. taking 3000-5000 g of medical vaseline and 1000-1200 g of medical paraffin, and uniformly mixing to obtain a component C; 4. and then adding the component A into the component C, uniformly stirring by using a high-shear stirrer at the stirring speed of 3000-3500 revolutions per minute for 10-15 minutes, standing for 30-50 minutes after uniform stirring, fully dissolving and dispersing the mixture, then adding the component B into the mixture, stirring at the stirring speed of 3000-3500 revolutions, uniformly stirring, adding the mixture of the component A, the component B and the component C into a double-roll extrusion coating machine, and coating the mixture on medical non-woven fabrics or other medical materials to obtain the neomycin medical dressing.
Description
Technical field
The present invention relates to a kind of method for preparing of neomycin medical dressing.
Background technology
Because existing a lot of wound infections are to lean on a large amount of antibiotics to solve, this kind method is a Drug therapy, be to inject blood of human body, life-time service be easy to generate Drug resistance, and use amount big, be prone to have side effects.
Summary of the invention
The invention provides a kind of method for preparing of neomycin medical dressing, its adopts neomycin is main body, and the neomycin consumption is less and be used for the surface of wound, is difficult for developing immunity to drugs, and the method is simple, and is easy to operate.
The present invention has adopted following technical scheme: a kind of method for preparing of neomycin medical dressing; It may further comprise the steps: step 1; Get calcium alginate fibre 1000 grams; It is ground into 200 orders-500 purpose powdery, gets behind neomycin and the calcium alginate fibre powder mix homogeneously of 6-10 grams subsequent usely then, be the A component; Step 2 is got ethylene glycol 50-80 grams, and water solublity azone 100-120 gram mix homogeneously is subsequent use, is the B component; Step 3 is got 3000-5000 gram medical grade vaseline and is added behind the 1000-1200 gram medical grade paraffin mix homogeneously subsequent usely, is the C component; Step 4; Get then and adopt high-shear impeller to stir after the A component adds the C component, its mixing time is 10-15 minute, and mixing speed is changeed for per minute 3000-3500; After the back placement that stirs made it fully dissolve dispersion after 30-50 minute; Add the B component again and stir, mixing time is 20-25 minute, and mixing speed is that 3000-3500 changes; After stirring, with being coated on the medical adhesive-bonded fabric in the two roller extrusion coating machines of the mixed material adding of A component, B component and C component or making the neomycin medical dressing in other medical material.
Calcium alginate fibre is ground into 200 purpose powderies in the step 1 of the present invention, and neomycin is 6 grams..Ethylene glycol is 50 grams and water solublity azone 100 grams in the step 2 of the present invention.Medical grade vaseline is 3000 grams in the step 3 of the present invention, and medical grade paraffin is 1000 grams.The time of stirring behind the A component adding C component in the step 4 of the present invention is 10 minutes; The speed that stirs is that per minute 3000 changes; The 30 minutes time that place the stirring back, adding B component stirring back mixing time again is 20 minutes, and mixing speed is 3000 commentaries on classics; Medical adhesive-bonded fabric of the present invention is calcium alginate non-woven fabrics, chitosan non-woven fabrics or viscose rayon non-woven fabrics etc., and other medical material of the present invention is to be contained in the plastics of toothpaste-like or the flexible pipe that aluminum stannum is processed to use.
The present invention has following beneficial effect: it is the production method of the multi-functional medical dressing of main body that the present invention adopts neomycin, and the neomycin consumption is less and be used for the surface of wound, is difficult for developing immunity to drugs, and the method is simple, and is easy to operate.This invention can be used for all infected wounds or non-infected wound and operative incision; Its effect be can kill in the wound because of the antibacterial that infects with prevent bacterial infection; And can absorb a large amount of transudates and the effect of repairing wound with the calcium alginate powder, be a kind of very economic medical dressing.
The specific embodiment
The invention provides a kind of method for preparing of neomycin medical dressing; It may further comprise the steps: step 1, get calcium alginate fibre 1000 grams, and it is ground into 200 purpose powderies; Get behind neomycin and the calcium alginate fibre powder mix homogeneously of 6 grams subsequent usely then, be the A component; Step 2 is got ethylene glycol 50 grams, and water solublity azone 100 gram mix homogeneously are subsequent use, are the B component; Step 3 is got 3000 gram medical grade vaseline and is added behind the 1000 gram medical grade paraffin mix homogeneously subsequent usely, is the C component; Step 4; Get then and adopt high-shear impeller to stir after the A component adds the C component, its mixing time is 10 minutes, and mixing speed is that per minute 3000 changes; After the back placement that stirs made it fully dissolve dispersion after 30 minutes; Add the B component again and stir, mixing time is 20 minutes, and mixing speed is 3000 commentaries on classics; After stirring; The mixed material of A component, B component and C component added be coated on the medical adhesive-bonded fabric in two roller extrusion coating machines or make the neomycin medical dressing in other medical material, medical adhesive-bonded fabric is calcium alginate non-woven fabrics, chitosan non-woven fabrics or viscose rayon non-woven fabrics etc., and other medical material is to be contained in the plastics of toothpaste-like or the flexible pipe that aluminum stannum is processed to use.
Claims (5)
1. the method for preparing of a neomycin medical dressing, it may further comprise the steps:
Step 1 is got calcium alginate fibre 1000 gram, and it is ground into 200 orders-500 purpose powdery, gets behind neomycin and the calcium alginate fibre powder mix homogeneously of 6-10 grams subsequent usely then, is the A component;
Step 2 is got ethylene glycol 50-80 grams, and water solublity azone 100-120 gram mix homogeneously is subsequent use, is the B component;
Step 3 is got 3000-5000 gram medical grade vaseline and is added behind the 1000-1200 gram medical grade paraffin mix homogeneously subsequent usely, is the C component;
Step 4; Get then and adopt high-shear impeller to stir after the A component adds the C component, its mixing time is 10-15 minute, and mixing speed is changeed for per minute 3000-3500; After the back placement that stirs made it fully dissolve dispersion after 30-50 minute; Add the B component again and stir, mixing time is 20-25 minute, and mixing speed is that 3000-3500 changes; After stirring, with being coated on the medical adhesive-bonded fabric in the two roller extrusion coating machines of the mixed material adding of A component, B component and C component or making the neomycin medical dressing in other medical material.
2. the method for preparing of neomycin medical dressing according to claim 1 is characterized in that calcium alginate fibre is ground into 200 purpose powderies in the step 1, and neomycin is 6 grams..
3. the method for preparing of neomycin medical dressing according to claim 1 is characterized in that ethylene glycol is 50 grams and water solublity azone 100 grams in the step 2.
4. the method for preparing of neomycin medical dressing according to claim 1 is characterized in that medical grade vaseline is 3000 grams in the step 3, and medical grade paraffin is 1000 grams.
5. the method for preparing of neomycin medical dressing according to claim 1; It is characterized in that the time of stirring behind the A component adding C component in the step 4 is 10 minutes; The speed of stirring is that per minute 3000 changes, and stirs the 30 minutes time that place the back, and adding B component stirring back mixing time again is 20 minutes; Mixing speed is 3000 commentaries on classics
The method for preparing of neomycin medical dressing according to claim 1 is characterized in that medical adhesive-bonded fabric is calcium alginate non-woven fabrics, chitosan non-woven fabrics or viscose rayon non-woven fabrics etc.,
The method for preparing of neomycin medical dressing according to claim 1 is characterized in that other medical material is to be contained in the plastics of toothpaste-like or the flexible pipe that aluminum stannum is processed to use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103930776A CN102406960A (en) | 2011-12-02 | 2011-12-02 | Preparation method of neomycin medical dressing |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2011103930776A CN102406960A (en) | 2011-12-02 | 2011-12-02 | Preparation method of neomycin medical dressing |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102406960A true CN102406960A (en) | 2012-04-11 |
Family
ID=45909492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2011103930776A Pending CN102406960A (en) | 2011-12-02 | 2011-12-02 | Preparation method of neomycin medical dressing |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102406960A (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB976301A (en) * | 1960-10-27 | 1964-11-25 | Calmic Ltd | Preparation and use of alginates |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101187153A (en) * | 2007-12-20 | 2008-05-28 | 沈兰凤 | Simple method for quickly adding silver ion for sterilization for calcium alginate fiber |
| CN101711887A (en) * | 2009-12-17 | 2010-05-26 | 卢亢 | Medical compound antiseptic dressing and preparation method thereof |
-
2011
- 2011-12-02 CN CN2011103930776A patent/CN102406960A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB976301A (en) * | 1960-10-27 | 1964-11-25 | Calmic Ltd | Preparation and use of alginates |
| CN1686573A (en) * | 2005-05-13 | 2005-10-26 | 褚省吾 | Lipid hydro colloid polymer anti bacterial dressing and its preparation method |
| CN101187153A (en) * | 2007-12-20 | 2008-05-28 | 沈兰凤 | Simple method for quickly adding silver ion for sterilization for calcium alginate fiber |
| CN101711887A (en) * | 2009-12-17 | 2010-05-26 | 卢亢 | Medical compound antiseptic dressing and preparation method thereof |
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| PB01 | Publication | ||
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| C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
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Application publication date: 20120411 |