CN102100826A - Chinese medicinal compound preparation for treating canine parvovirus enteritis and preparation method thereof - Google Patents

Abstract

The invention relates to a Chinese medicinal compound preparation for treating canine parvovirus enteritis and a preparation method thereof. The Chinese medicinal compound preparation is characterized by being prepared by mixing the following components in part by weight: 12 to 18 parts of Chinese pasque herb, 27 to 33 parts of parslane herb, 7 to 13 parts of golden thread, 12 to 18 parts of phellodendron, 12 to 18 parts of ash bark, 12 to 18 parts of astragalus, 12 to 18 parts of cinnamomvine, 7 to 13 parts of Chinese angelica, 7 to 13 parts of costustoot, 12 to 18 parts of ginger-processed pinellia tuber and 27 to 33 parts of sanguisorba root (half-and-half in raw sanguisorba root and cooked sanguisorba root), and preferably the Chinese medicinal compound preparation is prepared from the following components in part by weight: 15 parts of Chinese pasque herb, 30 parts of parslane herb, 10 parts of golden thread, 15 parts of phellodendron, 15 parts of ash bark, 15 parts of astragalus, 15 parts of cinnamomvine, 10 parts of Chinese angelica, 10 parts of costustoot, 15 parts of ginger-processed pinellia tuber and 30 parts of sanguisorba root (half-and-half in raw sanguisorba root and cooked sanguisorba root). The preparation method comprises the following steps of: weighing the medicaments according to a prescription, immersing the medicaments in cold water in an amount which is 8 to 12 times that of the medicaments for 0.5 to 1 hour, decocting for 0.5 to 2 hours, and filtering; adding water in an amount which is 6 to 10 times that of the medicaments into dregs of a decoction, decocting for 0.5 to 2 hours, and filtering; and merging filter liquor obtained at the two times, and concentrating to appropriate concentration to obtain the Chinese medicinal compound preparation for treating the canine parvovirus enteritis. The Chinese medicinal compound preparation has a reasonable formula, low cost and wide raw materials, and is easy to prepare.

Description

A kind of compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis and preparation method thereof

Technical field

The present invention designs a kind of Chinese medicine that is used for animal, designs a kind of compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis and preparation method thereof especially.

Background technology

The Canine Parvovirus enteritis is the dog acute infectious disease that is caused by the Canine Parvovirus enteritis, and its clinical manifestation has 2 types, i.e. enteritis type and myocarditis type.Enteritis type comparatively more to be seen.Principal character has first vomiting, back diarrhoea, and feces just is yellow or lark, then transfers the Fructus Lycopersici esculenti juice sample to, and abnormal smells from the patient is stench; After present tangible dewatering symptom, weak, become thin, spirit is depressed, enophthalmos,enophthalmus, skin elasticity reduces, slack anus is had blood in stool, stupor falls down to the ground; At last can be dead because of the concurrent acidosis of electrolyte disturbance.Primary disease is mainly in following pup of 5 monthly ages, and adult dogs is sent out less.At present hyper-immune serum, ribavirin, penicillin, gentamycin, dexamethasone, hemorrhage, vitamin B, vitamin C and symptomatic therapy of adopting more, therapeutic effect is not good enough, and the course of treatment is long, and side effect is big, the mortality rate height.Also useful compound Chinese medicinal preparation is oral or injection for curing, but curative effect is often not good, and the course of treatment is longer, can not practical requirement.

Summary of the invention

The present invention is intended to improve above-mentioned deficiency, and a kind of compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis is provided, and it is characterized in that counting by weight, Radix Pulsatillae 12-18 part, Herba Portulacae 27-33 part, Rhizoma Coptidis 7-13 part, Cortex Phellodendri 12-18 part, Cortex Fraxini 12-18 part, Radix Astragali 12-18 part, Rhizoma Dioscoreae 12-18 part, Radix Angelicae Sinensis 7-13 part, Radix Aucklandiae 7-13 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12-18 part, Radix Sanguisorbae (giving birth to ripe half and half) 27-33 part decoction is prepared from.

The medicine of above-mentioned treatment Canine Parvovirus enteritis, preferred proportion is counted by weight:

15 parts of the Radix Pulsatillaes, 30 parts of Herba Portulacaes, 10 parts of Rhizoma Coptidis, 15 parts of Cortex Phellodendris, 15 parts of Cortex Fraxinis, 15 parts of the Radixs Astragali, 15 parts of Rhizoma Dioscoreaes, 10 parts of Radix Angelicae Sinensis, 10 parts of the Radix Aucklandiae, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 30 parts of Radix Sanguisorbaes (giving birth to ripe half and half).

The preparation method of medicine of the present invention may further comprise the steps:

The medicine that takes by weighing recipe quantity adds 10 times of cold water soak 0.5h to the medical material amount, decoct 0.5-1h, filter, medicinal residues add 8 times of water to the medical material amount again, decoct 0.5-1h, filter, merge filtrate twice, the every 1ml of simmer down to contains the medicinal liquid of crude drug in whole 1.5g, plate frame filter fine straining with 0.45 μ m, fill, sterilization is the compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis.

Usage and dosage: every day 2 times, 2～3ml/kg body weight.

The specific embodiment

From the traditional Chinese veterinary medicine theory analysis, enteritis canine parvovirus is the heresy of diseases caused by exogenous pathogenic factor epidemic disease, the moving nutrient blood of heat, and damp and hot gathering in middle Jiao, pass in the part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels, make the gastrointestinal transfer function not normal, cause adverse rising of stomach-QI to be felt sick, damp invasion of lower energizer becomes to rush down.Therefore treatment is worked as with heat-clearing and toxic substances removing, and is drying damp and strengthening spleen, cooling blood for hemostasis, and stopping nausea and vomiting by lowering the adverse flow of QI is main.The present invention is according to the above rule of treatment and the traditional Chinese veterinary medicine principles of formulating prescriptions, selection has heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, drying damp and strengthening spleen, tonifying Qi and lifting yang, the Radix Pulsatillae of preventing or arresting vomiting effect, Herba Portulacae, Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini, the Radix Astragali, Rhizoma Dioscoreae, Radix Angelicae Sinensis, the Radix Aucklandiae, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens), Radix Sanguisorbae (giving birth to ripe half and half) prescription therapeutic, the wherein Radix Pulsatillae, Herba Portulacae heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery is a principal agent; Rhizoma Coptidis, Cortex Phellodendri, Cortex Fraxini heat clearing and damp drying, eliminating fire and detoxication are accessory drugs; The Radix Astragali, Rhizoma Dioscoreae tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, and Chinese angelica blood supplementing nourishes blood, Radix Aucklandiae promoting the circulation of QI to relieve pain, warming middle-JIAO for easing the stomach, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) stopping nausea and vomiting by lowering the adverse flow of QI are adjuvant drug; The Radix Sanguisorbae cooling blood for hemostasis, it is messenger drug that skin ulcer is held back in detoxifcation.All medicines share, and amount to heat-clearing and toxic substances removing, and are drying damp and strengthening spleen, eliminating pathogenic heat from blood to cure dysentery, the effect of stopping nausea and vomiting by lowering the adverse flow of QI.

Each raw material of Chinese medicine compositions of the present invention has following character and effect:

The Radix Pulsatillae: be the dry root of the ranunculaceae plant Radix Pulsatillae.Hardship, cold.Return stomach, large intestine channel.Heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery.Be used for toxic-heat and blood stasis, pudendal pruritus leukorrhagia, amebic dysentery.

Herba Portulacae: be the dry aerial parts of portulacaceous plant Herba Portulacae; Acid, cold.Return liver, large intestine channel.Heat-clearing and toxic substances removing, cooling blood for hemostasis.Be used for toxic-heat and blood stasis, the carbuncle furuncle, eczema, erysipelas, snake bite and insect sting is had blood in stool, hemorrhoidal bleeding, metrostaxis.

Rhizoma Coptidis: be the dry rhizome of ranunculaceae plant Rhizoma Coptidis, Coptis deltoidea C.Y.Cheng et Hsiao or Coptis Teeta Wall.Hardship, cold.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Heat clearing and damp drying, eliminating fire and detoxication.Be used for damp and hot feeling of fullness, the vomiting acid regurgitation, dysentery, jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood is told nosebleed, conjunctival congestion, the carbuncle furuncle is quenched one's thirst in toothache; External treatment eczema, eczema, auditory meatus is suppurated.

Cortex Phellodendri: the dry bark of rutaceae wampee or Cortex Phellodendri.Hardship, cold.Return kidney, urinary bladder channel.Heat clearing and damp drying, pathogenic fire purging are removed and are steamed, and skin ulcer is treated in detoxifcation.Be used for damp-heat dysentery, jaundice, leukorrhagia, pyretic stranguria, beriberi, flaccidity { is warded off }, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.

Cortex Fraxini: dry branch skin or the dried bark of Oleaceae plant fraxinus rhynchophylla Hance, Chinese ash, sharp leaf Chinese ash or place post Chinese ash.Bitter, puckery, cold.Return liver, gallbladder, large intestine channel.Heat clearing and damp drying, astringent therapy makes eye bright.Be used for hematodiarrhoea, have loose bowels, leucorrhea with red and white discharge, conjunctival congestion and swelling pain, order is given birth to the nebula film.

The Radix Astragali: the dry root of leguminous plant Radix Astagali or Radix Astragali.Sweet, temperature.Return lung, spleen channel.Invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, expelling pus and promoting granulation.It is weak to be used for the deficiency of vital energy, anorexia and loose stool, and sinking of QI of middle-JIAO, the chronic diarrhea proctoptosis, the metrorrhagia of having blood in stool, the exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle is difficult bursts, and burst for a long time and do not hold back, the blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst; Chronic nephritis proteinuria, diabetes.

Rhizoma Dioscoreae: the dry rhizome of Dioscoreaceae plant Rhizoma Dioscoreae.Sweet, flat.Return spleen, lung, kidney channel.The spleen reinforcing nourishing the stomach, the lung benefiting that promotes the production of body fluid, the kidney invigorating arresting seminal emission.Be used for insufficiency of the spleen lack of appetite, incessant chronic diarrhea, the deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, deficiency-heat is quenched one's thirst.The Rhizoma Dioscoreae (parched with bran) spleen reinforcing is good for the stomach.Be used for insufficiency of the spleen lack of appetite, the loose stool of having loose bowels, leukorrhagia.

Radix Angelicae Sinensis: the dry root of umbelliferae angelica.Sweet, hot, temperature.Return liver, the heart, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.Be used for blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.The Radix Angelicae Sinensis (processed with wine) promoting blood circulation to restore menstrual flow.Be used for the amenorrhea dysmenorrhea, rheumatic arthralgia, injury from falling down.

The Radix Aucklandiae: the dry root of the feverfew Radix Aucklandiae.Hot, bitter, temperature.Return spleen, stomach, large intestine, three warmers, gallbladder meridian.Promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion.Be used for breast gastral cavity distending pain, heavy behind the dysentery, food stagnation does not disappear, anorexia.The real intestinal antidiarrheal of Radix Aucklandiae (roasted).Stomachache is used to have loose bowels.

Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens): the dry tuber of the aroid Rhizoma Pinelliae.Suffering, temperature; Poisonous.Return spleen, stomach, lung meridian.Drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass.Be used for the abundant expectoration cough with asthma, the phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, the syncope due to accumulation of phlegm headache, vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus; Give birth to external treatment carbuncle sucutaneous nodule.Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) is used for stopping nausea and vomiting by lowering the adverse flow of QI more.

Radix Sanguisorbae: the dry root of the rosaceous plant Radix Sanguisorbae or the Radix Sanguisorbae that comes into leaves.Bitter, acid, puckery are slightly cold.Cooling blood for hemostasis, skin ulcer is held back in detoxifcation.Be used to have blood in stool hemorrhoidal bleeding, dysentery, metrorrhagia, burn due to hot liquid or fire, carbuncle sore tumefacting virus.

Medicine of the present invention is to the clinical therapeutic efficacy of Canine Parvovirus enteritis

With Drug therapy Canine Parvovirus enteritis 45 examples of the present invention, the result shows produce effects 36 examples in the medicine of the present invention 2 days, obvious effective rate 80%; Treat 3 days produce effects 41 examples, obvious effective rate 91%, total effective rate 95%; Treat 5 days produce effects 43 examples, obvious effective rate 95%, total effective rate 97%.

Claims (4)

1. compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis, it is characterized in that by following component by weight mixed preparing form: Radix Pulsatillae 12-18 part, Herba Portulacae 27-33 part, Rhizoma Coptidis 7-13 part, Cortex Phellodendri 12-18 part, Cortex Fraxini 12-18 part, Radix Astragali 12-18 part, Rhizoma Dioscoreae 12-18 part, Radix Angelicae Sinensis 7-13 part, Radix Aucklandiae 7-13 part, Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens) 12-18 part, Radix Sanguisorbae (giving birth to ripe half and half) 27-33 part.

2. the compound Chinese medicinal preparation of treatment Canine Parvovirus enteritis according to claim 1, it is characterized in that described various component optimum ratio amount is: 15 parts of the Radix Pulsatillaes, 30 parts of Herba Portulacaes, 10 parts of Rhizoma Coptidis, 15 parts of Cortex Phellodendris, 15 parts of Cortex Fraxinis, 15 parts of the Radixs Astragali, 15 parts of Rhizoma Dioscoreaes, 10 parts of Radix Angelicae Sinensis, 10 parts of the Radix Aucklandiae, 15 parts of Rhizoma Pinelliae (processed with Rhizoma Zingiberis Recens)s, 30 parts of Radix Sanguisorbaes (giving birth to ripe half and half).

3. the preparation method of the compound Chinese medicinal preparation of a treatment Canine Parvovirus enteritis according to claim 1 and 2 is characterized in that carrying out as follows: the medicine that takes by weighing recipe quantity adds 8-12 doubly to the cold water soak 0.5-1h of medical material amount, decocts 0.5-2h, filter, medicinal residues add 6-10 more doubly to the water of medical material amount, decoct 0.5-2h, filter, merge filtrate twice, be concentrated to debita spissitudo, filter fill, sterilization is the compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis.

4. the preparation method of claim 1 or 2 described medicines, it is characterized in that: the medicine that takes by weighing recipe quantity adds 10 times of cold water soak 0.5h to the medical material amount, decocts 0.5-1h, filter, medicinal residues add 8 times of water to the medical material amount again, decoct 0.5-1h, filter, merge filtrate twice, the every 1ml of simmer down to contains the medicinal liquid of crude drug in whole 1.5g, with the plate frame filter fine straining of 0.45 μ m, fill, sterilization is the compound Chinese medicinal preparation for the treatment of the Canine Parvovirus enteritis.