CN102058900A - Waterproof liquid bandage for wound surface protection and preparation method thereof - Google Patents
Waterproof liquid bandage for wound surface protection and preparation method thereof Download PDFInfo
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- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 claims abstract description 11
- FJWGYAHXMCUOOM-QHOUIDNNSA-N [(2s,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6s)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2r,3r,4s,5r,6s)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate Chemical compound O([C@@H]1O[C@@H]([C@H]([C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O)O[C@H]1[C@@H]([C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@@H](CO[N+]([O-])=O)O1)O[N+]([O-])=O)CO[N+](=O)[O-])[C@@H]1[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]1O[N+]([O-])=O FJWGYAHXMCUOOM-QHOUIDNNSA-N 0.000 claims abstract description 3
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Abstract
本发明涉及一种具有防水性的创面防护用液体绷带及其制备方法。所述液体绷带包括无水乙醇、乙酸乙酯、硝化纤维素、乙酰柠檬酸三丁酯、棕榈酸异丙酯和维生素E乙酸酯，以100克的液体绷带计，包括60克～90克的无水乙醇、1克～10克的乙酸乙酯、5克～15克的硝化纤维素、0.5克～2克的乙酰柠檬酸三丁酯、1克～5克的棕榈酸异丙酯以及0.1克～2克的维生素E乙酸酯。本发明具有防水性的创面防护用液体绷带为具有物理防护、促进伤口愈合双重功能的新型液体绷带，安全环保，成膜速度快并且使用简单方便、舒适性好，主要用于擦伤、割伤等皮肤浅表创面的防护。The invention relates to a waterproof liquid bandage for wound protection and a preparation method thereof. The liquid bandage includes absolute ethanol, ethyl acetate, nitrocellulose, acetyl tributyl citrate, isopropyl palmitate and vitamin E acetate, based on 100 grams of liquid bandage, including 60 grams to 90 grams absolute ethanol, 1-10 grams of ethyl acetate, 5-15 grams of nitrocellulose, 0.5-2 grams of acetyl tributyl citrate, 1-5 grams of isopropyl palmitate and 0.1 to 2 grams of vitamin E acetate. The waterproof liquid bandage for wound protection of the present invention is a new type of liquid bandage with dual functions of physical protection and wound healing, which is safe and environmentally friendly, has fast film forming speed, is simple and convenient to use, and has good comfort, and is mainly used for abrasions and cuts Protection of superficial skin wounds.
Description
技术领域technical field
本发明涉及一种创面防护用液体绷带及其制备方法，尤其涉及一种具有防水性的创面防护用液体绷带及其制备方法。The invention relates to a liquid bandage for wound protection and a preparation method thereof, in particular to a waterproof liquid bandage for wound protection and a preparation method thereof.
背景技术Background technique
在日常生活和工作中，人们常常会因为各种意外而发生皮肤表面的创伤，对于这种表皮创伤处理最常用的敷料为普通创可贴。普通创可贴一般是由纱布、橡胶类粘合剂以及附着于橡胶类粘合剂上的有效药物成分三部分组成。纱布起到支架作用，并有吸收创口渗出液的功能；橡胶类粘合剂粘附于皮肤表面起固定作用；有效药物成分起抗菌、消炎、止血的功能。普通创可贴在防水、阻菌、透气性及应用范围方面都有一定的局限性，使用时还会影响美观。为了适应市场需求，近年来很多国内外厂家都推出了一种新型的创口保护产品--液体绷带。In daily life and work, people often have skin surface wounds due to various accidents. The most commonly used dressing for this kind of superficial wound treatment is ordinary band-aid. Ordinary Band-Aids are generally composed of three parts: gauze, rubber adhesive, and effective pharmaceutical ingredients attached to the rubber adhesive. The gauze plays the role of a support and has the function of absorbing wound exudate; the rubber adhesive adheres to the skin surface to fix it; the effective drug ingredients have the functions of antibacterial, anti-inflammatory and hemostasis. Ordinary Band-Aids have certain limitations in terms of waterproof, anti-bacteria, air permeability and application range, and it will also affect the appearance when used. In order to meet the market demand, many domestic and foreign manufacturers have introduced a new type of wound protection product - liquid bandage in recent years.
液体绷带是一种新型创面防护材料，主要由成膜材料和溶剂构成，还有的添加了具有治疗性的功能物质或喷雾剂等。它克服了传统创面防护材料，如绷带、创可贴等对不规则创伤面或不方便使用的某些人体创伤部位防护能力差、防水透气性不好、对伤口的细菌感染无能为力、使用起来不美观的缺点，在临床实践中，取得了较好的创面防护效果。Liquid bandage is a new type of wound protection material, which is mainly composed of film-forming materials and solvents, and some have added therapeutic functional substances or sprays. It overcomes the traditional wound protection materials, such as bandages, band-aids, etc., which have poor protection ability on irregular wound surfaces or some human wound parts that are inconvenient to use, poor waterproof and breathable properties, powerless to wound bacterial infection, and unattractive to use. However, in clinical practice, better wound protection effects have been achieved.
在已有的关于液体绷带用于擦伤、割伤、轻度烧烫伤、手术伤口等的现有技术中，大多是以喷雾剂或喷胶剂的形态存在的，虽然该种剂型的产品具有使用简单方便、成膜速度快、防水和减少疤痕形成的效果，但也存在喷雾口容易堵塞、气雾推动剂对人体有害或污染环境、喷膜厚度不易掌握及作用效果持久性差等缺点。In the existing prior art about liquid bandages being used for abrasions, cuts, mild burns, surgical wounds, etc., most of them exist in the form of sprays or spray gels, although the products of this dosage form have Simple and convenient to use, fast film forming speed, waterproof and reducing scar formation, but there are also disadvantages such as easy blockage of the spray port, harmfulness of the aerosol propellant or pollution of the environment, difficulty in controlling the thickness of the spray film, and poor durability of the effect.
还有一些液体绷带产品是以涂膜剂或涂抹剂的形态存在的，该种剂型的产品中虽然添加了纯化水作为溶剂，具有使用安全、方便的特点，但在阻水性、成膜速度的方面存在一定的缺点。There are also some liquid bandage products that exist in the form of film-coating agents or smears. Although purified water is added as a solvent in this type of product, it is safe and convenient to use, but in terms of water resistance and film-forming speed There are certain shortcomings.
发明内容Contents of the invention
本发明针对现有液体绷带存在的上述不足，提供一种具有防水性的创面防护用液体绷带及其制备方法。Aiming at the above-mentioned shortcomings of the existing liquid bandages, the invention provides a waterproof liquid bandage for wound protection and a preparation method thereof.
本发明解决上述技术问题的技术方案如下：一种具有防水性的创面防护用液体绷带包括无水乙醇、乙酸乙酯、硝化纤维素、乙酰柠檬酸三丁酯、棕榈酸异丙酯和维生素E乙酸酯，以100克的液体绷带计，包括60克～90克的无水乙醇、1克～10克的乙酸乙酯、5克～15克的硝化纤维素、0.5克～2克的乙酰柠檬酸三丁酯、1克～5克的棕榈酸异丙酯以及0.1克～2克的维生素E乙酸酯。The technical scheme of the present invention to solve the above-mentioned technical problems is as follows: a liquid bandage for wound protection with waterproofness comprises absolute ethanol, ethyl acetate, nitrocellulose, acetyl tributyl citrate, isopropyl palmitate and vitamin E Acetate, based on 100 grams of liquid bandage, includes 60 to 90 grams of absolute ethanol, 1 to 10 grams of ethyl acetate, 5 to 15 grams of nitrocellulose, and 0.5 to 2 grams of acetyl Tributyl citrate, 1 to 5 grams of isopropyl palmitate, and 0.1 to 2 grams of vitamin E acetate.
进一步，所述液体绷带的pH值为6.0～8.0。Further, the pH value of the liquid bandage is 6.0-8.0.
本发明还提供一种解决上述技术问题的技术方案如下：一种具有防水性的创面防护用液体绷带的制备方法包括以下步骤：The present invention also provides a technical solution for solving the above-mentioned technical problems as follows: a preparation method of a waterproof liquid bandage for wound protection comprises the following steps:
1)将无水乙醇和乙酸乙酯进行混合形成均匀的混合液，其中，以制备100克的液体绷带计，无水乙醇的量为60克～90克，乙酸乙酯的量为1克～10克；1) Mix absolute ethanol and ethyl acetate to form a uniform mixed solution, wherein, based on the preparation of 100 grams of liquid bandage, the amount of absolute ethanol is 60 grams to 90 grams, and the amount of ethyl acetate is 1 gram to 90 grams. 10 grams;
2)在混合液中依次加入乙酰柠檬酸三丁酯、棕榈酸异丙酯和维生素E乙酸酯并进行搅拌，形成均一透明溶液，其中，以制备100克的液体绷带计，乙酰柠檬酸三丁酯的量为0.5克～2克，棕榈酸异丙酯的量为1克～5克，维生素E乙酸酯的量为0.1克～2克；2) Add acetyl tributyl citrate, isopropyl palmitate and vitamin E acetate in the mixed solution successively and stir to form a uniform transparent solution, wherein, in order to prepare 100 grams of liquid bandage, acetyl citrate tributyl The amount of butyl ester is 0.5 g to 2 g, the amount of isopropyl palmitate is 1 g to 5 g, and the amount of vitamin E acetate is 0.1 g to 2 g;
3)在均一透明溶液中加入硝化纤维素并进行搅拌使其溶解，其中，以制备100克的液体绷带计，硝化纤维素的量为5克～15克；3) adding nitrocellulose into the homogeneous transparent solution and stirring to dissolve it, wherein, based on the preparation of 100 grams of liquid bandage, the amount of nitrocellulose is 5 grams to 15 grams;
4)将溶解有硝化纤维素的溶液进行过滤，使硝化纤维素溶液中含有的不溶杂质及纤维过滤除去，再进行灌装即可。4) Filter the solution in which the nitrocellulose is dissolved to remove insoluble impurities and fibers contained in the nitrocellulose solution, and then fill it.
本发明的有益效果是：本发明具有防水性的创面防护用液体绷带为具有物理防护、促进伤口愈合双重功能的新型液体绷带，包括高分子成膜物质、有机溶剂、助溶剂和功能性物质，其中，高分子成膜物质对伤口起防护隔离作用，有机溶剂和助溶剂起溶解作用并具有快速挥发性，功能性物质起促进伤口愈合并减少疤痕形成的作用。本发明的液体绷带产品安全环保，成膜速度快并且使用简单方便、舒适性好，主要用于擦伤、割伤等皮肤浅表创面的防护。The beneficial effects of the present invention are: the waterproof liquid bandage for wound protection of the present invention is a novel liquid bandage with dual functions of physical protection and promoting wound healing, including polymer film-forming substances, organic solvents, co-solvents and functional substances, Among them, the polymer film-forming substances play the role of protecting and isolating the wound, organic solvents and co-solvents play the role of dissolving and have rapid volatility, and the functional substances play the role of promoting wound healing and reducing scar formation. The liquid bandage product of the present invention is safe and environment-friendly, has fast film-forming speed, is simple and convenient to use, and has good comfort, and is mainly used for the protection of superficial skin wounds such as abrasions and cuts.
具体实施方式Detailed ways
以下对本发明的原理和特征进行描述，所举实例只用于解释本发明，并非用于限定本发明的范围。The principles and features of the present invention are described below, and the examples given are only used to explain the present invention, and are not intended to limit the scope of the present invention.
实施例1：精确称取无水乙醇768克置烧杯中，加入60克乙酸乙酯，搅拌均匀后依次加入12克乙酰柠檬酸三丁酯、30克棕榈酸异丙酯、10克维生素E乙酸酯，搅拌，使成均一稳定透明溶液。在该溶液中加入120克硝化纤维素，持续搅拌至完全溶解。过滤，灌装，即为成品。Embodiment 1: Accurately weigh 768 grams of absolute ethanol and put it in a beaker, add 60 grams of ethyl acetate, stir well and then add 12 grams of acetyl tributyl citrate, 30 grams of isopropyl palmitate, 10 grams of vitamin E ethyl Ester, stirred to make a uniform stable transparent solution. 120 grams of nitrocellulose was added to this solution and stirring was continued until completely dissolved. Filtration, filling, that is the finished product.
实施例2：将具体实施例1中无水乙醇的量调整为778克，乙酸乙酯的量调整为50克，其余同具体实施例1。Embodiment 2: the amount of dehydrated alcohol in specific embodiment 1 is adjusted to 778 grams, and the amount of ethyl acetate is adjusted to 50 grams, and all the other are the same as specific embodiment 1.
实施例3：将具体实施例1中无水乙醇的量调整为762克，乙酰柠檬酸三丁酯的量调整为15克，硝化纤维素的量调整为150克，其余同具体实施例1。Embodiment 3: the amount of dehydrated alcohol in specific embodiment 1 is adjusted to 762 grams, and the amount of acetyl tributyl citrate is adjusted to 15 grams, and the amount of nitrocellulose is adjusted to 150 grams, and all the other are with specific embodiment 1.
本发明的液体绷带在使用时先清洁创面部位，待创面部位干燥后，将液体绷带直接涂抹在创面部位，液体绷带将在一分钟内自然干燥成膜，对创面起防护作用。When the liquid bandage of the present invention is used, the wound surface is first cleaned, and after the wound surface is dry, the liquid bandage is directly applied to the wound surface, and the liquid bandage will naturally dry and form a film within one minute to protect the wound surface.
本发明的液体绷带通过控制产品的微生物限度、细胞毒性、致敏、皮内反应等生物性能指标以确保产品的临床使用安全；通过控制产品的重金属含量和pH值6.0～8.0，以保证产品对患者的伤口和皮肤不产生刺激或毒性；通过控制产品成膜后的水蒸气透过率、阻水性、阻菌性，以保证产品对患者创面的防护效果。本发明产品中使用的维生素E乙酸酯具有延缓细胞老化、防止血液凝固、加速组织修复、减少疤痕形成的功效，其对擦伤、割伤等皮肤浅表创面具有良好的促进愈合的作用。本发明产品在成膜后具有透气、阻水、阻菌的效果，对伤口感染起到天然屏障作用。The liquid bandage of the present invention ensures the clinical use safety of the product by controlling biological performance indicators such as microbial limit, cytotoxicity, sensitization, and intradermal reaction of the product; by controlling the heavy metal content and pH value of the product from 6.0 to 8.0, to ensure that the product is safe for use. The patient's wound and skin do not produce irritation or toxicity; by controlling the water vapor transmission rate, water resistance and bacteria resistance of the product after film formation, the protective effect of the product on the patient's wound is guaranteed. The vitamin E acetate used in the product of the present invention has the effects of delaying cell aging, preventing blood coagulation, accelerating tissue repair, and reducing scar formation, and has a good effect of promoting healing on superficial skin wounds such as abrasions and cuts. The product of the invention has the effects of air permeability, water resistance and bacteria resistance after film formation, and acts as a natural barrier to wound infection.
通过检验，以上三个实施例的实验结果如下：By inspection, the experimental results of the above three embodiments are as follows:
本发明的液体绷带具有以下有益效果：1、成膜时间短，防护时间长；2、具有防水透气的特性，不影响正常生活；3、可有效地促进伤口愈合，减少疤痕的形成；4、有效阻止细菌对创伤面的侵入，防止感染；5、具有舒适性，简便实用，无毒副作用；6、覆盖面积可大可小，对不规则创面也有很好的防护性；7、透明材质，便于观察伤口愈合情况；8、外表美观大方。The liquid bandage of the present invention has the following beneficial effects: 1. The film-forming time is short and the protection time is long; 2. It is waterproof and breathable and does not affect normal life; 3. It can effectively promote wound healing and reduce the formation of scars; 4. Effectively prevent bacteria from invading the wound surface and prevent infection; 5. It is comfortable, convenient and practical, and has no toxic and side effects; 6. The coverage area can be large or small, and it has good protection against irregular wound surfaces; 7. Transparent material, It is convenient to observe the wound healing; 8. The appearance is beautiful and generous.
本发明的液体绷带中的高分子成膜材料选定为硝化纤维素，在国内销售的同类竞争产品中尚无雷同，另添加无毒增塑剂乙酰柠檬酸三丁酯改善成膜性能，使其更加柔软舒适；有机溶剂选定为无水乙醇和乙酸乙酯，其作为最常用的有机溶剂，相比较其他的有机溶剂来说对人体和环境危害更低，也更环保；功能性材料选定为维生素E乙酸酯，其作为人体必需的营养成分，能更好的促进新陈代谢，避免细胞氧化老化，减少疤痕的形成。The macromolecular film-forming material in the liquid bandage of the present invention is selected as nitrocellulose, and there is no similarity in similar competitive products sold in the country, and nontoxic plasticizer acetyl tributyl citrate is added to improve film-forming performance in addition, so that It is softer and more comfortable; organic solvents are selected as absolute ethanol and ethyl acetate, as the most commonly used organic solvents, which are less harmful to human body and environment than other organic solvents, and are more environmentally friendly; functional materials are selected Designated as vitamin E acetate, as an essential nutrient for the human body, it can better promote metabolism, avoid oxidative aging of cells, and reduce the formation of scars.
以上所述仅为本发明的较佳实施例，并不用以限制本发明，凡在本发明的精神和原则之内，所作的任何修改、等同替换、改进等，均应包含在本发明的保护范围之内。The above descriptions are only preferred embodiments of the present invention, and are not intended to limit the present invention. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principles of the present invention shall be included in the protection of the present invention. within range.
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| CN104814982A (en) * | 2015-04-21 | 2015-08-05 | 华侨大学 | Traditional Chinese medicine liquid adhesive bandage and preparation method |
| CN104825273A (en) * | 2015-05-30 | 2015-08-12 | 李孟平 | Method for preparing breathable self-adhesion elastic bandage |
| CN105288722A (en) * | 2015-11-13 | 2016-02-03 | 任宏 | Waterproof ventilating liquid adhesive bandage and preparation method thereof |
| CN105434404A (en) * | 2015-12-18 | 2016-03-30 | 江苏海智生物医药有限公司 | Film coating agent used for protecting wound surfaces |
| CN105688254A (en) * | 2016-03-08 | 2016-06-22 | 苏州市贝克生物科技有限公司 | Breathable medical bandage and preparation method thereof |
| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
| CN106367869A (en) * | 2016-08-26 | 2017-02-01 | 安徽省康富医疗用品有限公司 | Preparation method of waterproof non-latex high-elastic bandage |
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| CN108778234A (en) * | 2016-03-18 | 2018-11-09 | 小林制药株式会社 | External preparation for mitigating skin friction |
| CN108785739A (en) * | 2018-08-13 | 2018-11-13 | 中国人民解放军南京军区福州总医院 | A kind of full-service fluid adhesive bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
| CN108939145A (en) * | 2018-08-13 | 2018-12-07 | 西安中天生物医药有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN110101900A (en) * | 2019-06-20 | 2019-08-09 | 江西高大生物医疗科技有限公司 | A kind of film forming agent of the insulation blocking surface of a wound |
| CN110201220A (en) * | 2019-05-29 | 2019-09-06 | 利安隆博华（天津）医药化学有限公司 | A kind of liquid adhesive bandage and preparation method thereof improving osmotic absorption rate |
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| CN104814982A (en) * | 2015-04-21 | 2015-08-05 | 华侨大学 | Traditional Chinese medicine liquid adhesive bandage and preparation method |
| CN104814982B (en) * | 2015-04-21 | 2019-07-19 | 华侨大学 | A kind of traditional Chinese medicine liquid wound dressing and preparation method |
| CN104825273A (en) * | 2015-05-30 | 2015-08-12 | 李孟平 | Method for preparing breathable self-adhesion elastic bandage |
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| CN106075557A (en) * | 2016-06-24 | 2016-11-09 | 青岛中腾生物技术有限公司 | A kind of liquid wound protection material formed containing nanoaperture flexible membrane |
| CN107693840A (en) * | 2016-08-09 | 2018-02-16 | 北京纳通医学科技研究院有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN106367869A (en) * | 2016-08-26 | 2017-02-01 | 安徽省康富医疗用品有限公司 | Preparation method of waterproof non-latex high-elastic bandage |
| CN106367869B (en) * | 2016-08-26 | 2018-07-31 | 安徽省康富医疗用品有限公司 | A kind of preparation method of the non-latex high-elasticity bandage of water proofing property |
| CN108785739A (en) * | 2018-08-13 | 2018-11-13 | 中国人民解放军南京军区福州总医院 | A kind of full-service fluid adhesive bandage and preparation method thereof |
| CN108939145A (en) * | 2018-08-13 | 2018-12-07 | 西安中天生物医药有限公司 | A kind of liquid adhesive bandage and preparation method thereof |
| CN108904876A (en) * | 2018-10-15 | 2018-11-30 | 长春艾迪尔医用科技发展有限公司 | A kind of liquid wound dressing and preparation method thereof |
| CN110201220A (en) * | 2019-05-29 | 2019-09-06 | 利安隆博华（天津）医药化学有限公司 | A kind of liquid adhesive bandage and preparation method thereof improving osmotic absorption rate |
| CN110101900A (en) * | 2019-06-20 | 2019-08-09 | 江西高大生物医疗科技有限公司 | A kind of film forming agent of the insulation blocking surface of a wound |
| WO2023088120A1 (en) | 2021-11-17 | 2023-05-25 | 苏州清蓝生物医药科技有限公司 | Cannabidiol-containing hemostatic composition and application thereof as liquid bandage |
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