CN102000005B - Oral care solution - Google Patents
Oral care solution Download PDFInfo
- Publication number
- CN102000005B CN102000005B CN 201010563459 CN201010563459A CN102000005B CN 102000005 B CN102000005 B CN 102000005B CN 201010563459 CN201010563459 CN 201010563459 CN 201010563459 A CN201010563459 A CN 201010563459A CN 102000005 B CN102000005 B CN 102000005B
- Authority
- CN
- China
- Prior art keywords
- oral
- extract
- nursing liquid
- agent
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000419 plant extract Substances 0.000 claims abstract description 11
- 239000002904 solvent Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- GEYJUFBPCGDENK-UHFFFAOYSA-M sodium;3,8-dimethyl-5-propan-2-ylazulene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC=C(C)C2=C(S([O-])(=O)=O)C=C(C)C2=C1 GEYJUFBPCGDENK-UHFFFAOYSA-M 0.000 claims abstract description 7
- 239000002562 thickening agent Substances 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 230000000474 nursing effect Effects 0.000 claims description 21
- 239000007788 liquid Substances 0.000 claims description 20
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 9
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- 239000000284 extract Substances 0.000 claims description 9
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 6
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 4
- 241000628997 Flos Species 0.000 claims description 4
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical group [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 claims description 4
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 claims description 4
- 241000746375 Andrographis Species 0.000 claims description 3
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 3
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 claims description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 3
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 3
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 3
- 239000001103 potassium chloride Substances 0.000 claims description 3
- 235000011164 potassium chloride Nutrition 0.000 claims description 3
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 3
- 239000000600 sorbitol Substances 0.000 claims description 3
- 229940013618 stevioside Drugs 0.000 claims description 3
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 229960003500 triclosan Drugs 0.000 claims description 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 2
- 229920002565 Polyethylene Glycol 400 Polymers 0.000 claims description 2
- 229930003268 Vitamin C Natural products 0.000 claims description 2
- 229940094952 green tea extract Drugs 0.000 claims description 2
- 235000020688 green tea extract Nutrition 0.000 claims description 2
- JLFNLZLINWHATN-UHFFFAOYSA-N pentaethylene glycol Chemical compound OCCOCCOCCOCCOCCO JLFNLZLINWHATN-UHFFFAOYSA-N 0.000 claims description 2
- 235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
- 235000013024 sodium fluoride Nutrition 0.000 claims description 2
- 239000011775 sodium fluoride Substances 0.000 claims description 2
- 235000019154 vitamin C Nutrition 0.000 claims description 2
- 239000011718 vitamin C Substances 0.000 claims description 2
- 210000000214 mouth Anatomy 0.000 abstract description 20
- 230000000694 effects Effects 0.000 abstract description 9
- 208000024891 symptom Diseases 0.000 abstract description 9
- 238000004140 cleaning Methods 0.000 abstract description 6
- 206010018276 Gingival bleeding Diseases 0.000 abstract description 5
- 208000007117 Oral Ulcer Diseases 0.000 abstract description 5
- 208000002399 aphthous stomatitis Diseases 0.000 abstract description 5
- 206010068319 Oropharyngeal pain Diseases 0.000 abstract description 2
- 201000007100 Pharyngitis Diseases 0.000 abstract description 2
- 208000007565 gingivitis Diseases 0.000 abstract description 2
- 210000004877 mucosa Anatomy 0.000 abstract description 2
- 201000001245 periodontitis Diseases 0.000 abstract description 2
- 208000004371 toothache Diseases 0.000 abstract description 2
- 206010030973 Oral discomfort Diseases 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 235000003599 food sweetener Nutrition 0.000 abstract 1
- 208000011759 gum bleeding Diseases 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 239000002304 perfume Substances 0.000 abstract 1
- 239000003765 sweetening agent Substances 0.000 abstract 1
- 208000002193 Pain Diseases 0.000 description 9
- 208000024283 Gingival haemorrhages Diseases 0.000 description 5
- 206010006326 Breath odour Diseases 0.000 description 4
- 208000032139 Halitosis Diseases 0.000 description 4
- 230000002354 daily effect Effects 0.000 description 4
- 210000003026 hypopharynx Anatomy 0.000 description 4
- 230000008961 swelling Effects 0.000 description 4
- 241000196324 Embryophyta Species 0.000 description 3
- 206010025482 malaise Diseases 0.000 description 3
- 230000001680 brushing effect Effects 0.000 description 2
- 210000004195 gingiva Anatomy 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 229940034610 toothpaste Drugs 0.000 description 2
- 239000000606 toothpaste Substances 0.000 description 2
- 108010011485 Aspartame Proteins 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 208000002064 Dental Plaque Diseases 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 206010018286 Gingival pain Diseases 0.000 description 1
- 206010018291 Gingival swelling Diseases 0.000 description 1
- 208000025157 Oral disease Diseases 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 230000002159 abnormal effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000000605 aspartame Substances 0.000 description 1
- 235000010357 aspartame Nutrition 0.000 description 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
- 229960003438 aspartame Drugs 0.000 description 1
- 229960001950 benzethonium chloride Drugs 0.000 description 1
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 208000030194 mouth disease Diseases 0.000 description 1
- 210000002200 mouth mucosa Anatomy 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N p-menthan-3-ol Chemical compound CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000035943 smell Effects 0.000 description 1
- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- RXSHXLOMRZJCLB-UHFFFAOYSA-L strontium;diacetate Chemical compound [Sr+2].CC([O-])=O.CC([O-])=O RXSHXLOMRZJCLB-UHFFFAOYSA-L 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010563459 CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 201010563459 CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102000005A CN102000005A (en) | 2011-04-06 |
| CN102000005B true CN102000005B (en) | 2013-03-27 |
Family
ID=43807874
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 201010563459 Active CN102000005B (en) | 2010-11-27 | 2010-11-27 | Oral care solution |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN102000005B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN113398205A (en) * | 2021-07-01 | 2021-09-17 | 李霞 | Anti-cancer oral care solution and preparation method thereof |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102526280B (en) * | 2012-02-21 | 2013-08-14 | 牛俊芝 | Chinese medicinal composition for treating dental ulcer |
| CN102793836B (en) * | 2012-08-31 | 2014-05-28 | 褚明来 | Uncertain toothache fumigation medicament and preparation method and application method thereof |
| CN104042780A (en) * | 2014-06-20 | 2014-09-17 | 王玉果 | Oral cavity care solution |
| CN105213353B (en) * | 2015-10-16 | 2018-05-22 | 天津顶硕药业股份有限公司 | Compound oral film and preparation method containing sodium azulenesulfonate |
| CN105535591A (en) * | 2015-12-28 | 2016-05-04 | 张敏 | Oral care solution and preparation method for same |
| CN105963190A (en) * | 2016-06-21 | 2016-09-28 | 江苏奇力康皮肤药业有限公司 | Antisepsis and anti-inflammation mouth wash |
| CN106074274A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Oral care substance |
| CN106074341A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care liquid |
| CN106074275A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | The manufacture method of graininess oral care composition |
| CN106074277A (en) * | 2016-07-11 | 2016-11-09 | 周晗生 | Portable oral care thing |
| CN106491390B (en) * | 2016-12-13 | 2019-09-03 | 美晨集团股份有限公司 | A kind of persistently refrigerant antibacterial oral cavity cleaning and nursing liquid and preparation method thereof |
| CN106729650A (en) * | 2017-03-03 | 2017-05-31 | 江苏所罗门兄弟医学科技有限公司 | A kind of oral cavity gargle for tumor patient |
| CN107007539A (en) * | 2017-04-17 | 2017-08-04 | 江苏恩为众心生物医药有限公司 | Probiotics gargle production technology |
| CN106974847A (en) * | 2017-04-17 | 2017-07-25 | 江苏恩为众心生物医药有限公司 | Compound sodium azulenesulfonate gargle production technology |
| CN107007502A (en) * | 2017-04-18 | 2017-08-04 | 新疆中草堂医药科技有限公司 | The oral care composition of noresidue sense |
| JP6572278B2 (en) * | 2017-09-26 | 2019-09-04 | ダイヤ製薬株式会社 | New aqueous formulation |
| CN107789518A (en) * | 2017-10-25 | 2018-03-13 | 林振 | A kind of oral nursing liquid of oral mucositis caused by Prophylactic chemotherapy |
| CN107875085A (en) * | 2017-11-05 | 2018-04-06 | 长沙秋点兵信息科技有限公司 | oral care agent and preparation method thereof |
| CN107951733A (en) * | 2017-11-16 | 2018-04-24 | 江苏大学 | The preparation and its application of Azulene sodium sulfonate and Cetylpyridinium Chloride compound mouthwash |
| CN108113943B (en) * | 2018-02-05 | 2021-06-08 | 苏州工业园区方津口腔诊所有限公司 | A kind of child oral care method |
| CN108853487A (en) * | 2018-07-25 | 2018-11-23 | 长沙浩然医疗科技有限公司 | A kind of oral nursing liquid and preparation method thereof for treating canker sore |
| CN110251664A (en) * | 2019-07-05 | 2019-09-20 | 广州康云生物科技有限公司 | A kind of oral nursing liquid containing lysozyme and plant extracts |
| CN112618451A (en) * | 2020-11-24 | 2021-04-09 | 云南云药医药研究有限公司 | Composition containing natural antibacterial ingredients and application |
| CN113181102B (en) * | 2021-03-09 | 2022-12-30 | 北京圣永制药有限公司 | Mouthwash with functions of moistening oral cavity and refreshing breath and preparation method thereof |
| CN113230165B (en) * | 2021-04-02 | 2023-03-17 | 北京圣永制药有限公司 | A collutory containing marrubium vulgare extract with antiinflammatory and antibacterial effects |
| CN118845591A (en) * | 2024-09-05 | 2024-10-29 | 深圳市康杰尔生物科技有限公司 | Oral care solution for repairing mucous membrane and preparation method thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004196756A (en) * | 2002-12-13 | 2004-07-15 | Lion Corp | Oral composition |
| CN1842314A (en) * | 2003-08-27 | 2006-10-04 | 株式会社哈尼克斯 | Composition for application to tooth |
| CN101048149A (en) * | 2004-10-28 | 2007-10-03 | 兴和株式会社 | Solid pharmaceutical preparation dissolved in oral cavity |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
-
2010
- 2010-11-27 CN CN 201010563459 patent/CN102000005B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004196756A (en) * | 2002-12-13 | 2004-07-15 | Lion Corp | Oral composition |
| CN1842314A (en) * | 2003-08-27 | 2006-10-04 | 株式会社哈尼克斯 | Composition for application to tooth |
| CN101048149A (en) * | 2004-10-28 | 2007-10-03 | 兴和株式会社 | Solid pharmaceutical preparation dissolved in oral cavity |
| CN101062005A (en) * | 2007-05-22 | 2007-10-31 | 天津市顶硕科贸有限公司 | Medical toothpaste including sodium azulene sulfonate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106038414A (en) * | 2016-07-11 | 2016-10-26 | 周晗生 | Manufacturing method of portable mouth care product |
| CN113398205A (en) * | 2021-07-01 | 2021-09-17 | 李霞 | Anti-cancer oral care solution and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN102000005A (en) | 2011-04-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160222 Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee after: Tianjin top pharmaceutical technology Co., Ltd. Address before: 300110 Tianjin city Xiqing District Zhangjiawo Industrial Zone Fengze Road No. 6 Patentee before: Tianjin Jing Shuo Science and Trade Co., Ltd. |
|
| C56 | Change in the name or address of the patentee | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee after: Tianjin top pharmaceutical Limited by Share Ltd Address before: 300308, B205, building 8, airport business park, 80 Ring Road North, Tianjin Airport Economic Zone Patentee before: Tianjin top pharmaceutical technology Co., Ltd. |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: Oral care solution Effective date of registration: 20210318 Granted publication date: 20130327 Pledgee: Business Department of Bank of Tianjin Co.,Ltd. Pledgor: Tianjin top pharmaceutical Limited by Share Ltd. Registration number: Y2021120000008 |