CN102007924B - Bactericidal composition containing cyprodinil and tricyclazole - Google Patents
Bactericidal composition containing cyprodinil and tricyclazole Download PDFInfo
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- CN102007924B CN102007924B CN 201010565674 CN201010565674A CN102007924B CN 102007924 B CN102007924 B CN 102007924B CN 201010565674 CN201010565674 CN 201010565674 CN 201010565674 A CN201010565674 A CN 201010565674A CN 102007924 B CN102007924 B CN 102007924B
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- Prior art keywords
- tricyclazole
- cyprodinil
- bactericidal composition
- composition
- water dispersible
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- HAORKNGNJCEJBX-UHFFFAOYSA-N cyprodinil Chemical compound N=1C(C)=CC(C2CC2)=NC=1NC1=CC=CC=C1 HAORKNGNJCEJBX-UHFFFAOYSA-N 0.000 title claims abstract description 82
- 239000005758 Cyprodinil Substances 0.000 title claims abstract description 81
- DQJCHOQLCLEDLL-UHFFFAOYSA-N tricyclazole Chemical compound CC1=CC=CC2=C1N1C=NN=C1S2 DQJCHOQLCLEDLL-UHFFFAOYSA-N 0.000 title claims abstract description 81
- 239000000203 mixture Substances 0.000 title claims abstract description 40
- 230000000844 anti-bacterial effect Effects 0.000 title claims description 19
- 239000004562 water dispersible granule Substances 0.000 claims abstract description 14
- 239000000375 suspending agent Substances 0.000 claims abstract description 11
- 235000007164 Oryza sativa Nutrition 0.000 claims abstract description 9
- 235000009566 rice Nutrition 0.000 claims abstract description 9
- 241000221785 Erysiphales Species 0.000 claims abstract description 4
- 240000007594 Oryza sativa Species 0.000 claims abstract 2
- 239000000843 powder Substances 0.000 claims description 10
- 238000009736 wetting Methods 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 abstract description 9
- 230000002195 synergetic effect Effects 0.000 abstract description 8
- 239000002671 adjuvant Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 description 24
- 239000002131 composite material Substances 0.000 description 16
- 238000012360 testing method Methods 0.000 description 15
- 230000003449 preventive effect Effects 0.000 description 10
- 240000008067 Cucumis sativus Species 0.000 description 8
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 8
- 238000000034 method Methods 0.000 description 8
- 241000209094 Oryza Species 0.000 description 7
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 239000002270 dispersing agent Substances 0.000 description 7
- 239000000575 pesticide Substances 0.000 description 7
- 239000000080 wetting agent Substances 0.000 description 7
- -1 polyoxyethylene Polymers 0.000 description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000000945 filler Substances 0.000 description 5
- 229920005646 polycarboxylate Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000005995 Aluminium silicate Substances 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 239000002202 Polyethylene glycol Substances 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- 235000012211 aluminium silicate Nutrition 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 239000000470 constituent Substances 0.000 description 4
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- 229910021641 deionized water Inorganic materials 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 4
- 229920001223 polyethylene glycol Polymers 0.000 description 4
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- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- 229920001732 Lignosulfonate Polymers 0.000 description 3
- RCEAADKTGXTDOA-UHFFFAOYSA-N OS(O)(=O)=O.CCCCCCCCCCCC[Na] Chemical compound OS(O)(=O)=O.CCCCCCCCCCCC[Na] RCEAADKTGXTDOA-UHFFFAOYSA-N 0.000 description 3
- 240000003377 Shepherdia canadensis Species 0.000 description 3
- 235000018324 Shepherdia canadensis Nutrition 0.000 description 3
- 150000004996 alkyl benzenes Chemical class 0.000 description 3
- 230000008485 antagonism Effects 0.000 description 3
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- 239000003899 bactericide agent Substances 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- 229940077388 benzenesulfonate Drugs 0.000 description 3
- 239000011230 binding agent Substances 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
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- 239000003795 chemical substances by application Substances 0.000 description 3
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- 238000011835 investigation Methods 0.000 description 3
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- 230000001988 toxicity Effects 0.000 description 3
- 231100000419 toxicity Toxicity 0.000 description 3
- 241000894006 Bacteria Species 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 150000007942 carboxylates Chemical class 0.000 description 2
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 2
- 230000002070 germicidal effect Effects 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
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- 230000009036 growth inhibition Effects 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- ONUFESLQCSAYKA-UHFFFAOYSA-N iprodione Chemical compound O=C1N(C(=O)NC(C)C)CC(=O)N1C1=CC(Cl)=CC(Cl)=C1 ONUFESLQCSAYKA-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000007246 mechanism Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 230000000149 penetrating effect Effects 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 239000013049 sediment Substances 0.000 description 2
- 229920002545 silicone oil Polymers 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- LYCAIKOWRPUZTN-NMQOAUCRSA-N 1,2-dideuteriooxyethane Chemical compound [2H]OCCO[2H] LYCAIKOWRPUZTN-NMQOAUCRSA-N 0.000 description 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 1
- 244000215068 Acacia senegal Species 0.000 description 1
- 241000223600 Alternaria Species 0.000 description 1
- 241000255789 Bombyx mori Species 0.000 description 1
- 241001465180 Botrytis Species 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- 235000009852 Cucurbita pepo Nutrition 0.000 description 1
- 240000001980 Cucurbita pepo Species 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000223218 Fusarium Species 0.000 description 1
- 229920000084 Gum arabic Polymers 0.000 description 1
- 102000004157 Hydrolases Human genes 0.000 description 1
- 108090000604 Hydrolases Proteins 0.000 description 1
- 239000004354 Hydroxyethyl cellulose Substances 0.000 description 1
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 description 1
- 239000005867 Iprodione Substances 0.000 description 1
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
- 241000221960 Neurospora Species 0.000 description 1
- 102000011195 Profilin Human genes 0.000 description 1
- 108050001408 Profilin Proteins 0.000 description 1
- 102000001253 Protein Kinase Human genes 0.000 description 1
- 241000221662 Sclerotinia Species 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 241000607479 Yersinia pestis Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 239000000205 acacia gum Substances 0.000 description 1
- 235000010489 acacia gum Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003905 agrochemical Substances 0.000 description 1
- 229960000892 attapulgite Drugs 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 238000000498 ball milling Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000003915 cell function Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000018109 developmental process Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 229940095686 granule product Drugs 0.000 description 1
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000010534 mechanism of action Effects 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 229930182817 methionine Natural products 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229910052625 palygorskite Inorganic materials 0.000 description 1
- KFSLWBXXFJQRDL-UHFFFAOYSA-N peroxyacetic acid Substances CC(=O)OO KFSLWBXXFJQRDL-UHFFFAOYSA-N 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- 108060006633 protein kinase Proteins 0.000 description 1
- 235000021003 saturated fats Nutrition 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
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- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to a bacteriacide composition with synergistic effect, and the active components of the composition comprises cyprodinil and tricyclazole in weight ratio of (32:1)-(1:16). Adjuvant and excipient are added into the effective active components to prepare wettable powder, water dispersible granules and suspending agent, and the bacteriacide composition is mainly used for preventing and controlling gray mold, rice blast and powdery mildew of crops.
Description
Technical field
The invention belongs to technical field of pesticide, relate to a kind of application of bactericidal composition on crop pest that contains cyprodinil and tricyclazole.
Technical background
Cyprodinil, English name: cyprodinil, molecular formula: C
14H
15N
3, chemical name: 4-cyclopropyl-6-methyl-N-phenyl pyrimidine-2-amine.
Structural formula:
Cyprodinil belongs to the miazines bactericide.By suppressing the biosynthesis of methionine moral, suppress the secretion of hydrolase.Absorbed rapidly by blade in plant corpus, be penetrated into more than 30% in tissue, protected sediment is stored in blade; transmit in xylem, also transmit between blade, at high temperature metabolism is relatively rapid; sediment quite stable under low temperature in blade, the metabolite inanimate object is active.Tricyclazole (iprodione), molecular formula are C
13H
13Cl
2N
3O
3, chemical name: 3-(3,5-dichlorophenyl)-N-isopropyl-2,4-dioxo imidazoline-1-carboxylic acid amides.
Tricyclazole belongs to the agent of broad spectrum activity contact sterilization, the Profilin kinases, and signal in the cell of the many cell functions of control comprises that carbohydrate is in conjunction with the interference effect that enters fungal cell's component.Therefore, but its both Antifungi spore germination and generation also can suppress mycelial growth.Can play therapeutic action by root absorption.The bacterium such as Botrytis, neurospora, Sclerotinia, bulbil genus had bactericidal effect preferably.The bacterium such as Alternaria, the mould genus of the spore of wriggling, silk core genus, Fusarium, volt leather genus are also produced effect.
No matter be cyprodinil, tricyclazole or other efficient germicides, long-term use separately easily makes disease develop immunity to drugs, and causes the problem that dosage strengthens, preventive effect reduces, the lasting period shortens, and is unfavorable for environment sustainable development.The active ingredient of the different mechanisms of action is carried out composite, is to delay the disease method commonly used that develops immunity to drugs, and according to the effect in production application, judge this composite be synergistic effect or antagonism.Complex role is significantly filled a prescription, and can obviously improve preventive effect, greatly reduces the dosage of agricultural chemicals, also can enlarge fungicidal spectrum, improves germicidal efficiency.Cyprodinil is different from the tricyclazole mechanism of action, and mutually composite have good synergistic effect within the specific limits.And composite about cyprodinil and tricyclazole there is not yet relevant report at present at home and abroad.
Summary of the invention
The objective of the invention is to propose a kind of have synergistic function, use cost is low, preventive effect the is good bactericidal composition that contains cyprodinil and tricyclazole.
The present invention is achieved through the following technical solutions:
A kind of bactericidal composition that contains cyprodinil and tricyclazole, wherein cyprodinil and tricyclazole weight ratio are 32: 1 to 1: 16.
The described bactericidal composition that contains cyprodinil and tricyclazole, wherein the weight ratio of cyprodinil and tricyclazole is 8: 1 to 1: 4.
The described bactericidal composition that contains cyprodinil and tricyclazole, wherein the weight ratio of cyprodinil and tricyclazole is 4: 1 to 1: 2.
The described bactericidal composition that contains cyprodinil and tricyclazole is by the known method of the art personnel, can be made into the upper any formulation that allows of agricultural, more preferably as: wetting powder, water dispersible granules or suspending agent.
When making wetting powder, composition comprises following constituent content: cyprodinil 1～80%, tricyclazole 1～80%, dispersant 5～10%, wetting agent 2～10%, filler 8～90%.
Cyprodinil, tricyclazole, dispersant, wetting agent, filler are mixed, mix in mixed cylinder, mix again after airslide disintegrating mill is pulverized, namely can be made into cyprodinil tricyclazole wettable powder product.
When making water dispersible granules, composition comprises following constituent content: cyprodinil 1～80%, tricyclazole 1～80%, dispersant 3～12%, wetting agent 1～8%, disintegrant 1～10%, binding agent 1～8%, filler 10～90%.
Cyprodinil, tricyclazole, dispersant, wetting agent, disintegrant, filler etc. are obtained through air-flow crushing the particle diameter that needs together, then add other auxiliary agent such as binding agent, obtain the materials of granulating.With item quantitatively send in the fluidized bed granulation dryer through granulation and drying after, make cyprodinil tricyclazole water dispersible granule product.
Comprise following constituent content when composition is made suspending agent: cyprodinil 1～50%, tricyclazole 1～50%, dispersant 2～10%, wetting agent 2～10%, defoamer 0.1～1%, thickener 0.1～2%, antifreeze 0.1～8%, stabilizing agent 0.05%～3%, deionized water add to 100%.
Dispersant, wetting agent, defoamer, thickener, antifreeze in above-mentioned formulation material are mixed through high speed shear, add cyprodinil, tricyclazole, ball milling is 2～3 hours in ball mill, makes diameter of particle all below 5 μ m, makes cyprodinil tricyclazole suspending agent product.
Described dispersant is selected from polycarboxylate, lignosulfonates, the phonetic formaldehyde condensation products sulphate of alkylphenol-polyethenoxy, alkyl benzene sulfonate calcium salt, naphthalene sulfonic acid-formaldehyde condensation product sodium salt, alkylphenol-polyethenoxy is phonetic, aliphatic amine polyoxyethylene is phonetic, one or more in phonetic of polyoxyethylene carboxylate, ester polyoxyethylene.
Described wetting agent is selected from: one or more in lauryl sodium sulfate, neopelex, Nekal BX, wetting and penetrating agent F, spaonin powder, silkworm excrement, soapberry powder.
Described disintegrant is selected from: one or more in bentonite, urea, ammonium sulfate, aluminium chloride.
Described binding agent is selected from: one or more in gum Arabic, white dextrin, methylcellulose, PAA, polyvinylpyrrolidone, crospolyvinylpyrrolidone, polyethylene glycol, polyvinyl alcohol.
Described antifreeze is selected from: one or more in ethylene glycol, propane diols, glycerine, polyethylene glycol.
Described defoamer is selected from: one or more in silicone oil, silicone compound, C10-20 saturated fat acid compounds, C8-10 aliphatic alcohols compound.
Described thickener is selected from: one or more in xanthan gum, polyvinyl alcohol, polyethylene glycol.
Described filler is selected from: one or more in kaolin, diatomite, bentonite, attapulgite, white carbon, starch, precipitated calcium carbonate.
Composition of the present invention is mainly used in preventing and treating gray mold, rice blast, the powdery mildew on crops.
Beneficial effect of the present invention: (1) present composition effective active composition cyprodinil and tricyclazole belong to the bactericide of two kinds of different mechanisms of action, and both mutually are mixed and can produce conflict; (2) present composition has good synergistic effect within the specific limits, and preventive effect is higher than single dose, and dosage is little; (3) the present invention not with an organic solvent, is difficult for producing poisoning, is convenient to transportation and storage; (4) present composition has special efficacy to the gray mold on gourd, fruit and vegetable, rice blast, powdery mildew.
Embodiment
To further instruction of the present invention, the percentage in embodiment all is weight percentage below in conjunction with embodiment, but the present invention is not limited thereto.
The embodiment of the present invention is the method that adopts Toxicity Determination and field trial to combine.First by Toxicity Determination, the synergy ratio (SR) after clear and definite two kinds of medicaments are composite by a certain percentage, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect, on this basis, then carry out field trial.
Implementation of an application example one:
Cyprodinil and tricyclazole are composite to the gray mold of cucumber Toxicity Determination
Test medicine provides by Shaanxi agricultural chemicals Co., Ltd of U.S. nation.
After the effective inhibition concentration scope of each medicament was determined in prerun, each medicament was established respectively 5 dosage by active constituent content and is processed, and established the clear water contrast.Carry out with reference to " farm-chemical indoor determination test rule bactericide ", adopt the mycelial growth rate method to measure medicament to the virulence of gray mold of cucumber.Measure colony diameter with the right-angled intersection method after 72h, calculate and respectively process net growth, mycelial growth inhibition rate.
Net growth (mm)=measurement colony diameter-5
Mycelial growth inhibition rate is converted into probit value (y), and liquor strength (μ g/mL) converts logarithm value (x) to, tries to achieve virulence regression equation (y=a+bx) with method of least squares, and calculates thus the EC of every kind of medicament
50Value.Calculate the different proportioning synergy ratios (SR) of two medicaments according to the Wadley method simultaneously, SR＜0.5 is antagonism, and 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect.Computing formula is as follows:
Wherein: a, b are respectively cyprodinil and tricyclazole shared ratio in combination
A is cyprodinil
B is tricyclazole
Result of the test is as shown in table 1:
Table 1 cyprodinil, tricyclazole and composite toxicity test analysis of results table to gray mold of cucumber thereof
As shown in Table 1, cyprodinil, the tricyclazole EC to gray mold of cucumber
50Be respectively 5.47mg/L and 1.54mg/L.Cyprodinil and tricyclazole were mixed in scope at 32: 1～1: 16 and all show obvious synergistic effect.Wherein, both mixed synergies in 8: 1～1: 4 scope are comparatively desirable, and mixed synergies is particularly outstanding in 4: 1～1: 2 scope.
Implementation of an application example two: the implementation of Formulation Example
Embodiment 1 80% cyprodinil tricyclazole wettable powder
Cyprodinil 70%, tricyclazole 10%, polycarboxylate 5%, lauryl sodium sulfate 3%, spaonin powder 2%, kaolin 10%, mixture carries out air-flow crushing, makes 80% cyprodinil tricyclazole wettable powder.
Embodiment 2 60% cyprodinil tricyclazole wettable powders
Cyprodinil 40%, tricyclazole 20%, lignosulfonates 4%, wetting and penetrating agent 4%, white carbon 8%, kaolin add to 100%, and mixture carries out air-flow crushing, make 60% cyprodinil tricyclazole wettable powder.
Embodiment 3 45% cyprodinil tricyclazole wettable powders
Cyprodinil 15%, tricyclazole 30%, alkyl benzene sulfonate calcium salt 5%, the withered F3% of tea, white carbon 8%, bentonite add to 100%, and mixture carries out air-flow crushing, make 45% cyprodinil tricyclazole wettable powder.
Embodiment 4 80% cyprodinil tricyclazole water dispersible granules
Cyprodinil 40%, tricyclazole 40%, polycarboxylate 3%, lignosulfonates 3%, lauryl sodium sulfate 4%, ammonium sulfate 2%, starch add to 100%, mix to make 80% cyprodinil tricyclazole water dispersible granule.
Embodiment 5 55% cyprodinil tricyclazole water dispersible granules
Cyprodinil 30%, tricyclazole 25%, naphthalene sulfonic acid-formaldehyde condensation product sodium salt 3%, polyoxyethylene carboxylate 3%, soapberry powder 4%, sodium bicarbonate 3%, starch 20%, kaolin add to 100%, mix to make 55% cyprodinil tricyclazole water dispersible granule.
Embodiment 6 28% cyprodinil tricyclazole water dispersible granules
Cyprodinil 21%, tricyclazole 7%, alkylphenol-polyethenoxy are phonetic 5%, DBSA 2%, starch 20%, diatomite add to 100%, mix making 28% cyprodinil tricyclazole water dispersible granule.
Embodiment 7 50% cyprodinil tricyclazole suspending agents
Cyprodinil 40%, tricyclazole 10%, alkyl benzene sulfonate calcium salt 4%, sodium lignin sulfonate 3%, DBSA 4%, silicone oil 0.1%, xanthan gum 0.3%, deionized water adds to 100%, mixes to make 50% cyprodinil tricyclazole suspending agent.
Embodiment 8 35% cyprodinil tricyclazole suspending agents
Cyprodinil 20%, tricyclazole 15%, polycarboxylate 4%, soapberry powder 5%, silicone compound 0.1%, hydroxyethylcellulose 0.1%, ethylene glycol 2%, deionized water add to 100%, mix to make 35% cyprodinil tricyclazole suspending agent.
Embodiment 9 10% cyprodinil tricyclazole suspending agents
Cyprodinil 5%, tricyclazole 5%, polycarboxylate 2%, neopelex 2%, silicone compound 0.1%, polyethylene glycol 0.5%, glycerine 4%, deionized water add to 100%, mix to make 10% cyprodinil tricyclazole suspending agent.
Embodiment uses three cyprodinils and tricyclazole and the composite sick test of pesticide effectiveness of apple mildew of preventing and treating thereof
This experimental establishment is in Liquan County, Xianyang, Shanxi province city, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 50% tricyclazole wettable powder (commercial), 50% cyprodinil water dispersible granules (commercial).
Before medicine, the sick disease index of apple mildew is calculated in investigation, and in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once is total to dispenser 3 times.Investigated respectively the apple disease index and calculated preventive effect in 7 days, 14 days after dispenser for the third time.Experimental result is as follows:
Table 2 cyprodinil, tricyclazole and the composite sick test of pesticide effectiveness of apple mildew of preventing and treating thereof
As can be seen from Table 2, can effectively prevent and treat the apple mildew disease after cyprodinil and tricyclazole are composite, control efficiency all is better than contrasting medicament, and the lasting period is long.In the test scope of medication, the target crop is had no adverse effects, and apple mildew is had preventive effect preferably, preventive effect reaches more than 90%.
Implementation of an application example five: cyprodinil, tricyclazole and the composite control gray mold of cucumber test of pesticide effectiveness thereof
This experimental establishment is in Chang'an county, Xian City, Shanxi Province, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 50% tricyclazole wettable powder (commercial), 50% cyprodinil water dispersible granules (commercial).
Investigation state of an illness radix, total number of sheets, the sick number of sheets and sick leaf-size class number before medicine, in the their early stage dispenser, dispenser in every 7 days once, dispenser is 3 times altogether, investigates respectively disease index and calculates preventive effect in 7 days, 14 days after dispenser for the third time.Experimental result is as follows:
Table 4 cyprodinil, tricyclazole and the composite control gray mold of cucumber test of pesticide effectiveness thereof
As can be seen from Table 4, can effectively prevent and treat gray mold of cucumber after cyprodinil and tricyclazole are composite and give birth to, control efficiency all is better than contrasting medicament, in this test scope of medication, the target crop is had no adverse effects, and find that gray mold of cucumber is had good preventive effect, all can reach more than 90%.
Implementation of an application example six: cyprodinil and tricyclazole and the composite control rice blast test of pesticide effectiveness thereof
This experimental establishment is in Guangxi province Lipu county, and test medicine is researched and developed, provided by Shaanxi agricultural chemicals Co., Ltd of U.S. nation, contrast medicament 50% tricyclazole wettable powder (commercial), 50% cyprodinil water dispersible granules (commercial).
The investigation rice blast state of an illness before medicine, in the dispenser for the first time of state of an illness initial stage, dispenser in every 7 days once is total to dispenser 2 times.Investigated respectively the rice blast disease index and calculated preventive effect in 7 days, 14 days after dispenser for the third time.Experimental result is as follows:
Table 5 cyprodinil, tricyclazole and the composite control rice blast test of pesticide effectiveness thereof
As can be seen from Table 5, energy effectively preventing rice blast after cyprodinil and tricyclazole are composite, control efficiency all is better than contrasting medicament, and dosage is little, and the lasting period is long.The test scope of medication in to the target crop without harm.
Claims (5)
1. a bactericidal composition that contains cyprodinil and tricyclazole, is characterized in that bactericidal composition effective active composition is cyprodinil and tricyclazole, and the weight ratio of cyprodinil and tricyclazole is 32 ︰ 1 to 1 ︰ 16.
2. the bactericidal composition that contains cyprodinil and tricyclazole according to claim 1, it is characterized in that: wherein the weight ratio of cyprodinil and tricyclazole is 8 ︰ 1 to 1 ︰ 4.
3. the bactericidal composition that contains cyprodinil and tricyclazole according to claim 2, it is characterized in that: wherein the weight ratio of cyprodinil and tricyclazole is 4 ︰ 1 to 1 ︰ 2.
4. the bactericidal composition that contains cyprodinil and tricyclazole according to claim 1, it is characterized in that: bactericidal composition is made wetting powder, water dispersible granules or suspending agent.
5. the bactericidal composition of cyprodinil and tricyclazole that contains according to claim 1 is for the purposes of the gray mold of preventing and treating crop, rice blast, powdery mildew.
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| CN101039578A (en) * | 2004-10-12 | 2007-09-19 | 拜尔农作物科学股份公司 | Fungicidal active ingredient combinations containing fluoxastrobin |
| CN101087523A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| WO2010055909A1 (en) * | 2008-11-14 | 2010-05-20 | 日本農薬株式会社 | Pest control agent composition for agricultural and horticultural use |
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| CN101039578A (en) * | 2004-10-12 | 2007-09-19 | 拜尔农作物科学股份公司 | Fungicidal active ingredient combinations containing fluoxastrobin |
| CN101087523A (en) * | 2004-12-23 | 2007-12-12 | 巴斯福股份公司 | Fungicidal mixtures |
| WO2010055909A1 (en) * | 2008-11-14 | 2010-05-20 | 日本農薬株式会社 | Pest control agent composition for agricultural and horticultural use |
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Address after: 715500 Pucheng County of Shaanxi Province agricultural base industrial park Patentee after: Shaanxi Meibang Pesticide Co., Ltd. Address before: 710075, C, 15 floor, Jinqiao International Plaza, science and technology road, hi tech Zone, Shaanxi, Xi'an Patentee before: Shaanxi Meibang Pesticide Co., Ltd. |
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