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CN101995352A - Method and equipment for separating serum - Google Patents

Method and equipment for separating serum Download PDF

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Publication number
CN101995352A
CN101995352A CN2009100420469A CN200910042046A CN101995352A CN 101995352 A CN101995352 A CN 101995352A CN 2009100420469 A CN2009100420469 A CN 2009100420469A CN 200910042046 A CN200910042046 A CN 200910042046A CN 101995352 A CN101995352 A CN 101995352A
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Prior art keywords
heparin tube
centrifugal
weight
blood collection
collection tubes
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Application number
CN2009100420469A
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CN101995352B (en
Inventor
邓冠华
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Yangpu Medical Technology Co ltd
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GUANGZHOU IMPROVE MEDICAL CO Ltd
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  • Centrifugal Separators (AREA)

Abstract

The invention relates to a method for separating serum. The method comprises the following steps of: 1, providing blood collection tubes in which blood specimens are arranged, and heating the blood specimens in the blood collection tubes by using a constant temperature gas bath to make the temperatures of the blood specimens reach 37 DEG C; 2, grabbing the blood collection tubes by using mechanical hands; 3, automatically measuring the weight of the blood collection tubes, and recording the weight; 4, comparing the total weight of centrifugal canisters which are provided with the blood collection tubes and are symmetrically arranged on both sides, and placing the blood collection tubes on the lighter centrifugal canister; 5, calculating the total weight of the centrifugal canisters which are provided with the blood collection tubes; 6, placing the blood collection tubes into the two symmetric centrifugal canisters, and then calculating the weight difference of the centrifugal canisters on both sides; 7 selecting a counter weight of which the weight approaches to the weight difference of the two centrifugal canisters from standard counter weights, and putting the counter weight on the lighter side; 8, repeating the step 2 to the step 7 to complete the weighting of all the centrifugal canisters; 9, automatically centrifuging; 10, grabbing the centrifuged blood collection tubes out of the centrifugal canisters by using the mechanical hands, placing the blood collection tubes on an uncapping station, and putting the counter weights back; and 11, automatically uncapping the blood collection tubes. The invention also discloses equipment for automatically separating the serum.

Description

Serum separation method and equipment
Technical field
The present invention relates to a kind of serum separation method and equipment.
Background technology
In the medical care precess process, the doctor usually needs to gather patients'blood, and the serum in the blood of being gathered is separated, so that carry out the detection of aspects such as biochemistry, immunity, hormone by serum.
Existing serum lock out operation flow process is all manual fully carries out.When operation, manual test tube that accommodates blood of medical personnel is placed into inside the concentrator bowl of hydro-extractor from test tube rack, starts hydro-extractor then and carries out centrifugal.After centrifugal the finishing, the manual again test tube the hydro-extractor the inside takes out, or carries out craft and take off lid, perhaps is placed into other and takes off to take off on the equipment of lid to cover and operate.The manual like this serum separating action that carries out is not only wasted time and energy, and when carrying out these operations, operator's hand directly contacts heparin tube, and therefore the risk of being dyed by blood stains is arranged.
In addition, when carrying out centrifuging, the general concentrator bowl that requires heparin tube weight is placed into symmetrically hydro-extractor.Yet, rely on the operator to place test tube by hand and exist, and then cause the two ends weight imbalance of hydro-extractor correspondence when placing the inaccurate problem of weight assurance, not not steady when so just causing moving, shake greatlyyer, noise is also big, may cause the situation of haemolysis to occur then.
In addition, in preparation serum, the state that requires blood to be in to solidify fully.Because environment temperature is crossed factor low or that the time is too short, usually can't satisfy the requirement that blood solidifies fully.For now, the judgement whether serum is solidified relies on operator's eyes range estimation to carry out fully, and the accuracy that this range estimation is judged is extremely low, and centrifugal back floating fiber protein yarn/piece of meeting in serum, both influence the serum quality, and can stop up detecting instrument again when serious.
Before centrifugally operated, if heparin tube itself breaks, in ultracentrifugal process, powerful centrifugal force usually causes the test tube fragmentation so simultaneously, thereby causes the blood sample loss.And, the broken gasoloid serious harm health of operators that produces of test tube.
Thereby, be necessary to provide a kind of serum separation method and equipment, so that overcome the shortcoming and deficiency of prior art.
Summary of the invention
The purpose of this invention is to provide a kind of serum separation method and equipment, so that avoid relying on problem when placing test tube by hand fully in the prior art, the problem includes: inaccurate problem of counterweight and centrifugal vibrations are big so that the situation appearance of haemolysis; And realize the blood coagulation situation and the damaged situation of heparin tube being detected automatically before centrifugal, thereby test tube breaks and causes the loss of sample when avoiding centrifugal, and then obtain high-quality serum; After centrifuging, take off lid automatically simultaneously, whole process automation is finished, and medical personnel are freed from these onerous toils, carries out more valuable work.
To achieve these goals, the invention provides a kind of serum separation method, comprise step: 1, the heparin tube of placing blood preparation in it is provided,, makes the blood preparation temperature reach 37 ℃ the heating of the blood preparation constant temperature gas bath in the heparin tube; 2, grasp heparin tube by mechanical arm; 3, measure heparin tube weight automatically, record weight; 4, relatively be placed on the general assembly (TW) of having adorned heparin tube in the concentrator bowl of symmetrical both sides, select lighter one to be sidelong and to put heparin tube; 5, calculate the concentrator bowl general assembly (TW) of having placed heparin tube; 6, after two concentrator bowls of symmetry are all placed heparin tube, calculate both sides concentrator bowl weight difference; 7, the mass of choosing from the standard mass near two concentrator bowl weight differences is put into the lighter side of weight; 8, repeat the 2-7 step, finish all concentrator bowl counterweights; 9, centrifugal automatically; 10, mechanical arm crawls out the centrifugal heparin tube that finishes from concentrator bowl, is placed into to take off to cover on the station, and mass is put back to; 11, heparin tube is taken off lid automatically.The present invention discloses the serum automatic separation equipment.
The present invention provides a kind of serum separation equipment that is used for simultaneously, comprises interconnected centrifugal mechanism, flaw detection mechanism, automatic weighing mechanism, constant temperature preheating mechanism, cover extirpation machine structure and robotization conveying mechanism.
The invention has the advantages that: problem when having avoided manual placement test tube, the problem includes: inaccurate problem of counterweight and centrifugal vibrations are big so that the problem of haemolysis; Realize the automatic detection the blood coagulation situation and the damaged situation of heparin tube carried out before centrifugal, thereby test tube breaks and causes the loss of sample when avoiding centrifugal, and then obtain high-quality serum; Automatically take off lid after centrifuging, whole process automation is finished, and medical personnel are freed from these onerous toils, carries out more valuable work.
Describe the present invention in detail below by preferred embodiment.
Figure of description
Fig. 1 has showed the stereographic map of serum separation equipment of the present invention.
Fig. 2 has showed the stereographic map of another angle of serum separation equipment of the present invention.
Fig. 3 has showed the stereographic map of the members such as concentrator bowl of serum separation equipment of the present invention.
Fig. 4 has showed the stereographic map of rotary positioning mechanism.
Embodiment
Present invention is described now.
According to an aspect of the present invention, provide a kind of full-automatic serum separation method, may further comprise the steps:
1, provides the heparin tube that is placed with blood preparation in it, and the blood preparation in the heparin tube is carried out the heating of constant temperature gas bath, thereby make described blood preparation temperature reach 37 ℃;
2, grasp heparin tube after being heated by the mechanical arm of tensile force of belt sensor;
3, measure the weight of described heparin tube automatically, and write down measured weight;
4, relatively be placed on the general assembly (TW) of having adorned heparin tube in the concentrator bowl of symmetrical both sides, select lighter one to be sidelong and to put heparin tube;
5, calculate the general assembly (TW) of the concentrator bowl of having placed heparin tube;
6, after two concentrator bowls of symmetry are all placed heparin tube, calculate the weight difference of both sides concentrator bowl;
7, the mass of choosing from the standard mass near two concentrator bowl weight differences is put into the lighter side of weight;
8, repeat the 2-7 step, finish the counterweight of all concentrator bowls;
9, centrifugal automatically to heparin tube;
10, by mechanical arm the centrifugal heparin tube that finishes is crawled out from concentrator bowl, and be placed into to take off and cover on the station, then mass is put back to; At last
11, heparin tube is taken off lid automatically.
Wherein, the weight of the comparison both sides concentrator bowl in the step 4 also can be carried out in 2~3 steps.
The present invention relates to a kind of equipment that is used for full-automatic separation of serum simultaneously, and this equipment is used to realize above-mentioned serum automatic separation method.This equipment comprises interconnected centrifugal mechanism, flaw detection mechanism, automatic weighing mechanism, constant temperature preheating mechanism, cover extirpation machine structure and robotization conveying mechanism.
Wherein, described centrifugal mechanism comprises hydro-extractor, places concentrator bowl on the described hydro-extractor.Each concentrator bowl can be placed a plurality of heparin tubes.And a position of placing mass arranged on each concentrator bowl.Described mass is as counterweight.
Whether described flaw detection mechanism exists slight crack by ultrasonic, microwave or X-ray etc. to heparin tube, and situations such as breakage or internal injury are surveyed.Simultaneously, automatic flaw detection mechanism can detect the blood packing by supersonic detection method, thereby judges whether blood solidifies.
Described automatic weighing mechanism comprises the grasping mechanism that is used to grasp heparin tube.Being provided with in this grasping mechanism can be to the pulling force sensor of being measured by the weight of the heparin tube picked up.Simultaneously, this grasping mechanism can carry out the motion of above-below direction, so that place heparin tube.Described automatic weighing mechanism further comprises detent mechanism.Detent mechanism can be two coordinate setting mechanisms, or the rotary positioning mechanism around the centrifugal basket axis rotation.Described detent mechanism is used for the heparin tube of being placed is positioned.In addition, whole automatic weighing mechanism is assemblied in the centrifugal mechanism top.
Described constant temperature preheating mechanism has the zone of relative closure, is provided with device temperature automatically controlled and heating in this zone, simultaneously is placed with the fan that impels the air flow in the described zone again, so that allow temperature maintenance in the whole zone at 37 ℃.
Described cover extirpation machine structure comprises the anchor clamps that are used for holding test tubes and is used for the anchor clamps of clamping lid and the motion that lid is up pulled out.This motion can directly up pull out lid, perhaps up pulls out lid with rotation mode.
Described automatic delivering mechanism can be connected with the breadboard automatic assembly line of check, also can be used as independently built-in system running.During operation the heparin tube on the test tube rack commonly used of check laboratory is placed on the inner streamline.Making entire equipment inside is the work unit running with single heparin tube.Described automatic delivering mechanism comprises conveying belt, can place slide and the splendid attire vessel that be used to hold heparin tube of a plurality of conveying belt relatively on the conveying belt.Described splendid attire vessel by and conveying belt between the frictional force drives effect and move along the conveying belt rotation direction; And heparin tube picked and placeed transfer device on the conveying belt heparin tube splendid attire vessel from test tube rack.This mechanism can match, and when automatic delivering mechanism directly is connected with automatic assembly line, does not just need transfer device.
In with upper member, described centrifugal mechanism is the necessary mechanism that realizes that full-automatic serum separates with automatic weighing mechanism and robotization conveying mechanism, and other members such as constant temperature preheating mechanism, flaw detection mechanism are key mechanism, can make the serum quality of final acquisition higher.
And described cover extirpation machine structure is the mechanism of assisting, and can make automation degree of equipment higher.From result of use, the cover extirpation machine structure can alleviate medical personnel's workload greatly, but is inessential concerning the theme that serum separates, and is non-key.
Particularly with reference to figure 1-4, comprised first mechanical arm according to the transfer device 1 of serum separation equipment of the present invention, be used for test tube is transferred to inner automatic production line from test tube rack.Constant temperature preheating mechanism 2 is zones of a relative closure, heats in this zone, reaches 37 ℃., and be provided with heating wire and fan in the constant temperature preheating mechanism 2.Inner streamline 3 is as the ingredient of robotization conveying mechanism, has travelling belt relatively to make the container of the splendid attire test tube of slip above, as circulation splendid attire heparin tube usefulness.4 pairs of heparin tubes of flaw detection mechanism are detected a flaw, and the packing of blood is surveyed.Automatic weighing mechanism 5 has comprised grasping mechanism, rotary positioning mechanism.Among the figure, label 6 expressions are used to realize the mass of counterweight purpose.
Centrifugal mechanism 7 has comprised centrifugal rotating shaft, support, concentrator bowl, motor etc.Label 8 expression cover extirpation machine structures.The centre bit of concentrator bowl 9 is equipped with a special room of placing mass.
Heparin tube container containing 10 can recycle.The centrifugal runing rest of label 11 expressions, label 12 expression rotary positioning mechanisms.Label 13 expression grasping mechanisms grasp test tube.
Pulling force sensor 14 detects the weight of the test tube of being picked up, and writes down weight with the software of equipment, and carries out the weight summation.
Rectilinear motion detent mechanism 15 mainly is that the hole in the concentrator bowl is located.
The invention still further relates to a kind of device and ballasting method of full-automatic counterweight as previously described.
The present invention has such beneficial effect: alleviate medical personnel's working strength, raise the efficiency; Avoid improving the quality that serum separates because heparin tube is placed the unbalanced centrifugal vibrations that cause so that the situation of haemolysis; Simultaneously, by to test tube flaw detection and full-automatic operation, reduce medical personnel's blood and because the aerocolloidal infection probability of the broken generation of heparin tube.
Above disclosed only is the preferred embodiments of the present invention, can not limit the present invention's interest field certainly with this, and therefore the equivalent variations of being done according to the present patent application claim still belongs to the scope that the present invention is contained.

Claims (10)

1. serum separation method is characterized in that may further comprise the steps:
1, provides the heparin tube that is placed with blood preparation in it, and the blood preparation in the heparin tube is carried out the heating of constant temperature gas bath, thereby make described blood preparation temperature reach 37 ℃;
2, grasp heparin tube after being heated by the mechanical arm of tensile force of belt sensor;
3, measure the weight of described heparin tube automatically, and write down measured weight;
4, relatively be placed on the general assembly (TW) of having adorned heparin tube in the concentrator bowl of symmetrical both sides, select lighter one to be sidelong and to put heparin tube;
5, calculate the general assembly (TW) of the concentrator bowl of having placed heparin tube;
6, after two concentrator bowls of symmetry are all placed heparin tube, calculate the weight difference of both sides concentrator bowl;
7, the mass of choosing from the standard mass near two concentrator bowl weight differences is put into the lighter side of weight;
8, repeat the 2-7 step, finish the counterweight of all concentrator bowls;
9, centrifugal automatically to heparin tube;
10, by mechanical arm the centrifugal heparin tube that finishes is crawled out from concentrator bowl, and be placed into to take off and cover on the station, then mass is put back to; At last
11, heparin tube is taken off lid automatically.
2. method according to claim 1 is characterized in that: the weight of the comparison both sides concentrator bowl in the described step 4 is carried out in 2~3 steps.
3. a serum separation equipment that is used for the described method of claim 1 is characterized in that comprising interconnected centrifugal mechanism, flaw detection mechanism, automatic weighing mechanism, constant temperature preheating mechanism, cover extirpation machine structure and robotization conveying mechanism.
4. equipment according to claim 3 is characterized in that: described centrifugal mechanism comprises hydro-extractor, places concentrator bowl on the described hydro-extractor, and a position of placing mass is arranged on each concentrator bowl.
5. equipment according to claim 3 is characterized in that: whether described flaw detection mechanism exists slight crack by ultrasonic, microwave or X-ray etc. to heparin tube, and situations such as breakage or internal injury are surveyed; And automatic flaw detection mechanism is detected the blood packing by supersonic detection method, thereby judges whether blood solidifies.
6. equipment according to claim 3 is characterized in that: described automatic weighing mechanism comprises the grasping mechanism that is used to grasp heparin tube, the pulling force sensor that setting can be measured the weight of the heparin tube picked up in this grasping mechanism; Described automatic weighing mechanism further comprises detent mechanism.
7. equipment according to claim 6 is characterized in that: described detent mechanism is two coordinate setting mechanisms or is the rotary positioning mechanism around the centrifugal basket axis rotation; Described automatic weighing mechanism is assemblied in the top of described centrifugal mechanism.
8. equipment according to claim 3 is characterized in that: described constant temperature preheating mechanism has the zone of relative closure, is provided with device temperature automatically controlled and heating in this zone, is placed with the fan that impels the air flow in the described zone simultaneously again.
9. equipment according to claim 3 is characterized in that: described cover extirpation machine structure comprises the anchor clamps that are used for holding test tubes and is used for the anchor clamps of clamping lid and the motion that lid is up pulled out; This motion directly up pulls out lid, perhaps up pulls out lid with rotation mode.
10. equipment according to claim 3, it is characterized in that: described automatic delivering mechanism comprises conveying belt, place slip and the splendid attire vessel that be used to hold heparin tube of a plurality of conveying belt relatively on the conveying belt, described splendid attire vessel by and conveying belt between the frictional force drives effect and move along the conveying belt rotation direction; And heparin tube picked and placeed transfer device on the conveying belt heparin tube splendid attire vessel from test tube rack.
CN200910042046.9A 2009-08-21 2009-08-21 Method and equipment for separating serum Active CN101995352B (en)

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Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
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Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104338621A (en) * 2013-08-05 2015-02-11 上海安亭科学仪器厂 Centrifuge with automatic decapping function
CN105879949A (en) * 2014-12-05 2016-08-24 安顺市晶英科技研发有限责任公司 Test tube clamping device
CN106362873A (en) * 2015-07-24 2017-02-01 蓝伊精机株式会社 Centrifugal separation device and centrifugal seperation method
CN106999955A (en) * 2014-07-29 2017-08-01 约阿希姆·格斯特尔 Components for preparing large quantities of samples for analytical methods
CN108014929A (en) * 2018-01-17 2018-05-11 山东建筑大学 A kind of combined type medical test solution centrifugal device
CN108452958A (en) * 2018-01-25 2018-08-28 陈柯 A kind of Bioexperiment equipment
CN109085367A (en) * 2018-07-31 2018-12-25 美德太平洋(天津)生物科技股份有限公司 Blood coagulation instrument that is a kind of easy to carry and having protective device
CN109647637A (en) * 2019-01-30 2019-04-19 北京博奥晶典生物技术有限公司 A kind of wireless device for high speed centrifugation equipment in-situ temperature real-time measurement
CN109694810A (en) * 2019-01-10 2019-04-30 祁光荣 Full automatic serum separator
CN109939758A (en) * 2019-03-28 2019-06-28 上海市嘉定区中心医院 An automatic blood pretreatment and pipetting platform for blood rheology detection
CN111473850A (en) * 2020-04-22 2020-07-31 睿科集团(厦门)股份有限公司 Online automatic counterweight method for mechanical arm before centrifugation
CN113219186A (en) * 2021-01-29 2021-08-06 武汉市农业科学院 Full-automatic heavy metal analyzer
CN115738387A (en) * 2022-10-31 2023-03-07 江苏稳润光电有限公司 Double-barrel centrifugal defoaming machine capable of selecting counter weight and operation method thereof

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CN101504307A (en) * 2009-03-26 2009-08-12 北京兆维科技股份有限公司 Manipulator cantilever weighing apparatus

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Publication number Priority date Publication date Assignee Title
WO1993015407A1 (en) * 1992-01-27 1993-08-05 Guido Ruggeri Method and apparatus for the full automation of a laboratory performing analyses
EP0629858A1 (en) * 1993-06-16 1994-12-21 Kabushiki Kaisha Nittec Sample preparation apparatus
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Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104338621A (en) * 2013-08-05 2015-02-11 上海安亭科学仪器厂 Centrifuge with automatic decapping function
CN106999955A (en) * 2014-07-29 2017-08-01 约阿希姆·格斯特尔 Components for preparing large quantities of samples for analytical methods
CN105879949A (en) * 2014-12-05 2016-08-24 安顺市晶英科技研发有限责任公司 Test tube clamping device
CN105879949B (en) * 2014-12-05 2018-09-28 嘉兴维特拉电气科技有限公司 A test tube clamping device
CN106362873A (en) * 2015-07-24 2017-02-01 蓝伊精机株式会社 Centrifugal separation device and centrifugal seperation method
CN108014929A (en) * 2018-01-17 2018-05-11 山东建筑大学 A kind of combined type medical test solution centrifugal device
CN108014929B (en) * 2018-01-17 2023-09-01 山东建筑大学 A combined medical test solution centrifugal device
CN108452958B (en) * 2018-01-25 2019-01-08 平湖市华晟机械有限公司 A kind of Bioexperiment equipment
CN108452958A (en) * 2018-01-25 2018-08-28 陈柯 A kind of Bioexperiment equipment
CN109085367A (en) * 2018-07-31 2018-12-25 美德太平洋(天津)生物科技股份有限公司 Blood coagulation instrument that is a kind of easy to carry and having protective device
CN109085367B (en) * 2018-07-31 2023-09-26 美德太平洋(天津)生物科技股份有限公司 Portable coagulometer with protecting device
CN109694810A (en) * 2019-01-10 2019-04-30 祁光荣 Full automatic serum separator
CN109647637A (en) * 2019-01-30 2019-04-19 北京博奥晶典生物技术有限公司 A kind of wireless device for high speed centrifugation equipment in-situ temperature real-time measurement
CN109939758A (en) * 2019-03-28 2019-06-28 上海市嘉定区中心医院 An automatic blood pretreatment and pipetting platform for blood rheology detection
CN111473850A (en) * 2020-04-22 2020-07-31 睿科集团(厦门)股份有限公司 Online automatic counterweight method for mechanical arm before centrifugation
CN113219186A (en) * 2021-01-29 2021-08-06 武汉市农业科学院 Full-automatic heavy metal analyzer
CN113219186B (en) * 2021-01-29 2024-02-09 武汉市农业科学院 Full-automatic heavy metal analyzer
CN115738387A (en) * 2022-10-31 2023-03-07 江苏稳润光电有限公司 Double-barrel centrifugal defoaming machine capable of selecting counter weight and operation method thereof

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