CN101473813A - Composition for preserving cadaver sample and preparation method thereof - Google Patents
Composition for preserving cadaver sample and preparation method thereof Download PDFInfo
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- CN101473813A CN101473813A CNA2009100039871A CN200910003987A CN101473813A CN 101473813 A CN101473813 A CN 101473813A CN A2009100039871 A CNA2009100039871 A CN A2009100039871A CN 200910003987 A CN200910003987 A CN 200910003987A CN 101473813 A CN101473813 A CN 101473813A
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Abstract
The invention discloses a composition for preserving corpse samples, and relates to corrosion prevention, rot resistance and preservation of corpses in medical teaching and scientific work. The composition comprises rot-proof and mold-proof active component, infiltration modifier and wetting agent, wherein the rot-proof and mold-proof active component is diacetate; the infiltration modifier is one or a mixture of two or more than two of nitrate, sulfate or hydrochloride according to any proportion; and the wetting agent is polylol. The invention also provides a method for preparing the composition for preserving the corpse samples. The method is special for preserving the corpse samples after setting treatment; the composition contains sodium diacetate, is used for preserving animal or human corpses, and can effectively solve the problems of corrosion prevention, rot resistance and preservation of the corpses; and the preservation liquid has the characteristics of long rot resistance time, good effect, no formaldehyde, safety and non-toxicity, easily obtained raw materials, and low price.
Description
Technical field
The present invention relates to corpse mildew-resistant in medical teaching and the research work, anticorrosion, the composition and method of making the same preserved.
Technical background
For a long time, formalin solution is continued to use as the wet soak of preserving of cadaver sample, its main component---formaldehyde in the anatomy experiment chamber of medical colleges and schools always.Formalin has advantages such as fixedly induration to tissue is strong, good penetrability, price is low, the sterilization and anticorrosion effect is good.But also have obvious weak point in the actual application: 1) formaldehyde has the intense stimulus smell, and formaldehyde can cause the infringement of many organs multisystem, is defined as carcinogenic and teratogenesis shape material by the World Health Organization, is the allergen of generally acknowledging.Formaldehyde serious harm contact personnel's is healthy.2) have a strong impact on teaching efficiency.The penetrating odor of formaldehyde, to the stimulation of respiratory mucosa, eye conjunctiva, cause the shouting pain of student's eye, headache, dizziness, weak, that stomach is received is poor, palpitaition, insomnia and vegetative nervous disorder etc., part student's failure of memory, learning interest decline.3) major polluting atmosphere environment and water environment.At present a lot of units have adopted the powerful air draft equipment of bleeding in order to improve teaching environment, also just with pollution transportation in atmosphere; If handling then, PARA FORMALDEHYDE PRILLS(91,95) waste water needs expensive facility, some unit even directly waste water is entered in the sewer.4) mildew-resistant concentration is difficult to control.Mildew-resistant liquid is volatile, contacts with air for a long time, and polymerization can take place, and separates out the paraformaldehyde or the metaformaldehyde precipitation of white, and whole bottle formalin can become the stock white pasty state when serious, thereby the stoste fixed effect is sharply reduced, even can not be used for fixing anticorrosion.5) sample of in formalin solution, preserving for a long time, the corpse rubicundity, hardness is big, and its surface (particularly spleen, liver, bone etc. are rich in the place of haemoglobin) will adhere to one deck brown materials, if do not remove the effect of influence being observed sample, cause misleading easily yet.Formaldehyde is a many-side people in the chemical industry, but also becomes our hard to guard against healthy killer, and the harm of formaldehyde more and more is subjected to the attention of user and environmental administration.
Patent CN 200810125376 discloses a kind of a kind of corpus antiseptic that contains formaldehyde, benzoic acid ethanol, sodium acetate, acetone, glacial acetic acid and perfume that the invention discloses; Because its composition still contains formaldehyde, serious harm contact personnel's is healthy.Patent CN88105221A discloses and a kind of materials such as ethanol, potassium acetate, sodium sulphate, glycerine, water has been configured to mixed liquor in proportion, and CN1086658A discloses a kind of preservation liquid that is formed by benzoate, ethanol, potassium nitrate, glycerine configuration.These two kinds preserve liquid all with ethanol as effective anti-corrosion composition, long-term use can cause the hardening of sample albumen, distortion, and because ethanol is volatile, valid density is difficult to control in the use.Add preservatives such as Sodium Benzoate, potassium sorbate at present in cadaver-preservative fluid, it suppresses corpse effect and not obvious of going mouldy and rot.
Summary of the invention
Provide a kind of cadaver sample long-term storage but the present invention will solve, use the environment-friendly type preserving corpse samples liquid of back anticorrosion composition noresidue in environment simultaneously.
Technical problem to be solved by this invention provides a kind of composition that is used for preserving corpse samples, said composition comprises anticorrosion antimold activity composition, Osmolyte regulator and humectant, described anticorrosion antimold activity composition is a diacetate, described Osmolyte regulator is one or both and the above mixture that mixes with arbitrary proportion in nitrate, sulphate or the hydrochloride, and described humectant is a polyalcohol.The present invention also provides this preserving corpse samples preparation of compositions method.
For solving the problems of the technologies described above, the technical scheme that the present invention takes is: a kind of composition that is used for preserving corpse samples, said composition comprises anticorrosion antimold activity composition, Osmolyte regulator and humectant, described anticorrosion antimold activity composition is a sodium Diacetate, described Osmolyte regulator is nitrate, sulphate or hydrochloride, described humectant is a polyalcohol, and each composition weight is:
Diacetate: 0.5-2 weight portions;
Quaternary ammonium compound: 0.5-2.5 weight portions;
Osmolyte regulator: 5-25 weight portions;
Humectant: 5-20 weight portions.
Wherein, described quaternary ammonium compound is a Dodecyl trimethyl ammonium chloride, and one or both reach the above mixture that mixes with arbitrary proportion in 16～OTAC, the Quaternium 24; Described Osmolyte regulator is the mixture that one or both and the above arbitrary proportion thereof in potassium nitrate, sodium nitrate, nitrate of lime, magnesium nitrate, zinc nitrate, potassium sulphate, sodium sulphate, magnesium sulfate, zinc sulphate, potassium chloride, sodium chloride, calcium chloride, magnesium chloride, the zinc chloride mixes; Described humectant is the mixture that one or both and the above arbitrary proportion in ethylene glycol, diethylene glycol, propane diols, dipropylene glycol, the glycerine mixes.
The present invention also provides the above-mentioned preparation of compositions method that is used for preserving corpse samples, comprises the steps:
1. take by weighing diacetate 1-5 weight portions, add as humectant 5-20 weight portion normal temperature and pressures and stir.
2. add Osmolyte regulator 5-25 weight portions in the mixture in the step 1, stir.
The present invention has following technique effect:
1. cadaver-preservative fluid of the present invention is used for the preservation of animal or human's body corpse can effectively solve the problem of embalming, mildew-resistant, preservation, and the characteristics of this preservation liquid are that the anticorrosion mildew-resistant time is long, effective, do not contain formaldehyde, and safety non-toxic, raw material are easy to get, low price.
2. selected mildew-resistant, the preservative of cadaver-preservative fluid of the present invention is sodium Diacetate, is the anticorrosion level of a kind of food-grade, has efficient mildew-proof function, soluble in water, do not change the corpse characteristic, be not subjected to the influence of the pH value of corpse own, can keep original color of corpse and composition.
3. that cadaver-preservative fluid of the present invention has is safe, nontoxic, noresidue, no carcinogenic, no aberration inducing.Be applied to the anticorrosion of cadaver-preservative fluid, and obtained effect preferably.
Embodiment
Embodiment 1
A kind of composition that is used for preserving corpse samples, it is by sodium Diacetate, and Dodecyl trimethyl ammonium chloride, potassium nitrate, sodium sulphate, ethylene glycol are formed.Use said composition, prepare 1000 liters of preserving corpse samples liquid, take by weighing each component by following weight:
Sodium Diacetate: 1.0 kilograms
Dodecyl trimethyl ammonium chloride: 1.5 kilograms
Potassium nitrate: 10.0 kilograms
Sodium sulphate: 5.0 kilograms
Ethylene glycol: 15.0 kilograms
Add running water to 1000 kilogram
The preparation process of this preserving corpse samples liquid is:
Elder generation is the sodium Diacetate of weight as above, adds ethylene glycol, Dodecyl trimethyl ammonium chloride, and normal temperature and pressure stirs, and adds potassium nitrate, sodium sulphate again, adds to 1000 liters with running water, stirs half an hour, is finished product after leaving standstill.
Embodiment 2
A kind of composition that is used for preserving corpse samples, it is by sodium Diacetate, and Dodecyl trimethyl ammonium chloride, potassium nitrate, sodium sulphate, ethylene glycol are formed.Use said composition, prepare 1000 liters of preserving corpse samples liquid, take by weighing each component by following weight:
Diacetic acid potassium: 2.0 kilograms
Dodecyl trimethyl ammonium chloride: 2.0 kilograms
Magnesium nitrate: 10.0 kilograms
Sodium sulphate: 5.0 kilograms
Dipropylene glycol: 15.0 kilograms
Add running water to 1000 kilogram
The preparation process of this preserving corpse samples liquid is:
Elder generation is the diacetic acid potassium of weight as above, adds dipropylene glycol, Dodecyl trimethyl ammonium chloride, and normal temperature and pressure stirs, and adds magnesium nitrate, sodium sulphate again, adds to 1000 liters with running water, stirs half an hour, is finished product after leaving standstill.
Embodiment 3
A kind of composition that is used for preserving corpse samples, it is by sodium Diacetate, and Dodecyl trimethyl ammonium chloride, potassium nitrate, sodium sulphate, ethylene glycol are formed.Use said composition, prepare 1000 liters of preserving corpse samples liquid, take by weighing each component by following weight:
Sodium Diacetate: 1.0 kilograms
Dodecyl trimethyl ammonium chloride: 2 kilograms
Potassium nitrate: 10.0 kilograms
Zinc sulphate: 5.0 kilograms
Glycerine: 18.0 kilograms
Add running water to 1000 kilogram
The preparation process of this preserving corpse samples liquid is:
Elder generation is the sodium Diacetate of weight as above, adds glycerine, Dodecyl trimethyl ammonium chloride, and normal temperature and pressure stirs, and adds potassium nitrate, zinc sulphate again, adds to 1000 liters with running water, stirs half an hour, is finished product after leaving standstill.
Using method:
The cadaver sample that has fixed is invaded bubble in the cadaver sample cabinet that preserving corpse samples fluid composition finished product of the present invention is housed, and through more than 2 years, sample does not go mouldy, color and luster, shape all do not have change.
Preserving corpse samples liquid and existing several corpse preservation also the preservation effect contrast of following table for using the present composition:
Claims (6)
1, a kind of composition that is used for preserving corpse samples, said composition comprises fungus-proof antisepsis active component, Osmolyte regulator and humectant, it is characterized in that, described mildew-resistant, anticorrosion active ingredient are diacetate, described Osmolyte regulator is one or both and the above mixture that mixes with arbitrary proportion in nitrate, sulphate or the hydrochloride, described humectant is a polyalcohol, and each ingredients weight parts is:
Diacetate: 0.5-2 weight portions;
Quaternary ammonium compound: 0.5-2.5 weight portions;
Osmolyte regulator: 5-25 weight portions;
Humectant: 5-20 weight portions.
2, a kind of composition that is used for preserving corpse samples according to claim 1 is characterized in that, described diacetate is one or both in sodium Diacetate or the diacetic acid potassium.
3, a kind of composition that is used for preserving corpse samples according to claim 1, it is characterized in that, described quaternary ammonium compound is a Dodecyl trimethyl ammonium chloride, and one or both reach the above mixture that mixes with arbitrary proportion in 16～OTAC, the Quaternium 24.
4, a kind of composition that is used for preserving corpse samples according to claim 1, it is characterized in that described Osmolyte regulator is the mixture that one or both and the above arbitrary proportion thereof in potassium nitrate, sodium nitrate, nitrate of lime, magnesium nitrate, zinc nitrate, potassium sulphate, sodium sulphate, magnesium sulfate, zinc sulphate, potassium chloride, sodium chloride, calcium chloride, magnesium chloride, the zinc chloride mixes.
5, a kind of composition that is used for preserving corpse samples according to claim 1 is characterized in that, described humectant is the mixture that one or both and the above arbitrary proportion in ethylene glycol, diethylene glycol, propane diols, dipropylene glycol, the glycerine mixes.
6, a kind of preparation of compositions method that is used for preserving corpse samples according to claim 1 comprises the steps:
A. take by weighing diacetate 0.5-2 weight portions, add as humectant 5-20 weight portion normal temperature and pressures and stir;
B. add Osmolyte regulator 5-25 weight portions in the mixture in the steps A, stir.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100039871A CN101473813A (en) | 2009-01-23 | 2009-01-23 | Composition for preserving cadaver sample and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2009100039871A CN101473813A (en) | 2009-01-23 | 2009-01-23 | Composition for preserving cadaver sample and preparation method thereof |
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| CN101473813A true CN101473813A (en) | 2009-07-08 |
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| CNA2009100039871A Pending CN101473813A (en) | 2009-01-23 | 2009-01-23 | Composition for preserving cadaver sample and preparation method thereof |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578073A (en) * | 2012-02-07 | 2012-07-18 | 王永红 | Preserving fluid for biological sample |
| CN103430935A (en) * | 2013-08-27 | 2013-12-11 | 孙志超 | Softening agent for treating butterfly specimen |
| CN110720452A (en) * | 2019-11-05 | 2020-01-24 | 南通大学 | Method for optimizing preservation of pathological gross specimens |
| CN111280161A (en) * | 2018-12-06 | 2020-06-16 | 西安培华学院 | A kind of biological specimen preservation solution and preparation method thereof |
| CN115868475A (en) * | 2022-11-16 | 2023-03-31 | 江苏海洋大学 | Marine animal specimen preserving fluid and preparation method thereof |
-
2009
- 2009-01-23 CN CNA2009100039871A patent/CN101473813A/en active Pending
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102578073A (en) * | 2012-02-07 | 2012-07-18 | 王永红 | Preserving fluid for biological sample |
| CN103430935A (en) * | 2013-08-27 | 2013-12-11 | 孙志超 | Softening agent for treating butterfly specimen |
| CN103430935B (en) * | 2013-08-27 | 2015-05-27 | 孙志超 | Softening agent for treating butterfly specimen |
| CN111280161A (en) * | 2018-12-06 | 2020-06-16 | 西安培华学院 | A kind of biological specimen preservation solution and preparation method thereof |
| CN110720452A (en) * | 2019-11-05 | 2020-01-24 | 南通大学 | Method for optimizing preservation of pathological gross specimens |
| CN110720452B (en) * | 2019-11-05 | 2021-11-19 | 南通大学 | Method for optimizing preservation of pathological gross specimens |
| CN115868475A (en) * | 2022-11-16 | 2023-03-31 | 江苏海洋大学 | Marine animal specimen preserving fluid and preparation method thereof |
| CN115868475B (en) * | 2022-11-16 | 2024-02-23 | 江苏海洋大学 | A kind of marine animal specimen preservation solution and preparation method thereof |
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Application publication date: 20090708 |