CN101391131B - Nervous system magnetic induction electrical stimulation device - Google Patents
Nervous system magnetic induction electrical stimulation device Download PDFInfo
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- CN101391131B CN101391131B CN 200810224171 CN200810224171A CN101391131B CN 101391131 B CN101391131 B CN 101391131B CN 200810224171 CN200810224171 CN 200810224171 CN 200810224171 A CN200810224171 A CN 200810224171A CN 101391131 B CN101391131 B CN 101391131B
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- 230000006698 induction Effects 0.000 title claims abstract description 68
- 230000000638 stimulation Effects 0.000 title claims abstract description 25
- 210000000653 nervous system Anatomy 0.000 title claims abstract description 5
- 230000005284 excitation Effects 0.000 claims abstract description 41
- 230000004936 stimulating effect Effects 0.000 claims abstract description 20
- 210000005036 nerve Anatomy 0.000 claims abstract description 19
- 210000000278 spinal cord Anatomy 0.000 claims description 6
- 239000003990 capacitor Substances 0.000 claims description 2
- 230000005684 electric field Effects 0.000 abstract description 10
- 230000000694 effects Effects 0.000 description 11
- 238000000034 method Methods 0.000 description 6
- 239000007943 implant Substances 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- 230000001537 neural effect Effects 0.000 description 5
- 230000005611 electricity Effects 0.000 description 3
- 230000005674 electromagnetic induction Effects 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
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- 210000004556 brain Anatomy 0.000 description 2
- 238000011161 development Methods 0.000 description 2
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- 238000010586 diagram Methods 0.000 description 2
- 230000005672 electromagnetic field Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 208000020431 spinal cord injury Diseases 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 206010010774 Constipation Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 229920006362 Teflon® Polymers 0.000 description 1
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- 238000013461 design Methods 0.000 description 1
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- 238000000338 in vitro Methods 0.000 description 1
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- 230000010354 integration Effects 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
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- 230000007383 nerve stimulation Effects 0.000 description 1
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Abstract
一种神经系统磁感应电刺激装置，包括刺激器(1)、激励线圈(2)、感应线圈(3)、刺激电极(4)。感应线圈(3)位于患者皮下，与患者背部平面平行。刺激电极(4)固定在患者脊柱(5)上，刺激电极(4)一端与感应线圈(3)连接，另一端与神经相接触。激励线圈(2)位于患者体外，与感应线圈(3)同轴。刺激器(1)放置在患者近旁，为激励线圈(2)提供脉冲电流。激励线圈(2)与感应线圈(3)之间的距离在10～30mm之间。刺激时，激励线圈(2)在由刺激器(1)提供的脉冲电流的作用下产生脉冲磁场，穿过感应线圈(3)的磁力线随时间发生变化，感应线圈(3)中会产生感应电动势并在两电极之间的神经上形成电场，从而使神经兴奋。
A nervous system magnetic induction electrical stimulation device, comprising a stimulator (1), an excitation coil (2), an induction coil (3), and a stimulation electrode (4). The induction coil (3) is located under the patient's skin, parallel to the plane of the patient's back. The stimulating electrode (4) is fixed on the patient's spine (5), one end of the stimulating electrode (4) is connected to the induction coil (3), and the other end is in contact with the nerve. The excitation coil (2) is located outside the body of the patient and is coaxial with the induction coil (3). The stimulator (1) is placed near the patient to provide pulse current for the excitation coil (2). The distance between the excitation coil (2) and the induction coil (3) is between 10mm and 30mm. During stimulation, the excitation coil (2) generates a pulsed magnetic field under the action of the pulse current provided by the stimulator (1), and the magnetic field lines passing through the induction coil (3) change with time, and an induced electromotive force is generated in the induction coil (3) And form an electric field on the nerve between the two electrodes, so that the nerve is excited.
Description
Technical field
The present invention relates to a kind of nervous system magnetic induction electrical stimulation device.
Background technology
Spinal cord injury (Spinal Cord Injury, SCI) reconstruction after is one of difficult point of Neuroscience Research, along with microelectric technique, the development of microprocessing and neuroscience, rehabilitation engineering worker's successful application functional electric stimulation (Functional Electrical Stimulation, FES) system makes the Patients of Spinal enough handss of energy and lower limb complete partial function, and acquisition control is to a certain degree urinated and the function of relieving constipation.In order to reach the purpose of life-time service, the FES system need to implant, but power volume is huge and the problem that needs to change is restricting the development of FES always.Just have the scholar to propose to utilize a pair of emission-receiving coil to realize the transmission of electric energy as far back as the seventies in last century, receiving coil receives the radiofrequency signal from transmitting coil, and to be translated into dc signal be the stimulator power supply that implants.At present a lot of implantation type electric stimulation devices adopt this power transfer mode, and frequency is generally the hundreds of megahertz, as United States Patent (USP) 5741316,6804561,7177698,7209792,7392091.Although this power transfer mode makes the size of implant devices get reducing to a certain extent, the implant devices volume is still larger, has affected patient's activity.Also do not have at present patent to adopt pulse electromagnetic field to carry out energy delivery.
Utilize in addition oscillating electric field to stimulate to promote axon regeneration after SCI, make patient's recovered part function.Patent about oscillating electric field stimulating instrument and Therapeutic Method has four at present, is United States Patent (USP) (patent No. 4774967,4919140,6975907 and 7199110), and device adopts battery powered, and therapeutic modality is for implanting or semi-implantation type.But existing research finds that using the effective time of oscillating electric field stimulation therapy is 6-12 month, existing battery is difficult to satisfy the requirement (otherwise volume can be very large) that works long hours, therefore existing patented technology is difficult to accomplish long-time implantation, and the device of semi-implantation type (1 year) problem such as be difficult to avoid infection that works long hours.
With respect to the FES system that needs implant devices, noninvasive magnetic stimulating method is more easily accepted by the patient.It is according to Faraday law of electromagnetic induction that magnetic stimulates, and the time-varying magnetic field that utilizes the changing currents with time in coil to produce forms induction field, thereby makes neural excitation on nerve.Say in a sense, magnetic stimulates and the principle of electricity irritation is identical, and when the induction field value surpassed threshold value, nerve will be excited, reaches the effect identical with electricity irritation.At present in the patent that magnetic stimulates, all that the more shallow nerve in position is stimulated, Chinese patent 200510015749.4 has designed multilead magnetic stimulator for brain, fix 128 coils in the head-shield inboard, corresponding to 128 circuit controll blocks, the all coils shape is identical, and field stimulation can reach any range of human brain.Chinese patent 200510077042.6 uses a pair of coaxial coil to carry out stimulated in vitro to nerve, and two coils all need power drives.Chinese patent 94102890.9 stimulates magnetic and with ultrasonic combining, subcutaneous nerve is stimulated.Although above-mentioned patent has realized stimulating for the external noinvasive of nerve, but with decaying apart from rapid, magnetic stimulates also can't act on the nerve of putting than deep-seated in body due to magnetic field, and because the focusing of magnetic stimulation is poor, can cause non-target tissue excited during stimulation, cause side effect.
Summary of the invention
The objective of the invention is to overcome existing implanted electric stimulator and contain built-in power and bulky, and directly magnetic stimulates depth as shallow, the poor shortcoming of focusing, by being embedded in vivo induction coil and stimulating electrode, then the method that carrying out magnetic stimulates improves supraneural electric field intensity, and can be applied to the human body deep nerve stimulates.
The present invention is comprised of device two parts in external device and body.External device comprises stimulator and excitation coil, is used to provide pulsewidth less than the pulsed magnetic field of 0.5 millisecond, but not radio frequency electromagnetic field; Body comprised induction coil and stimulating electrode in inner minute, be used for producing induction electromotive force and complete electricity irritation, and in body, part itself does not contain built-in power.
Part is very little induction coil to be imbedded subcutaneous in body of the present invention, and described coil two ends connect and neural contacted stimulating electrode by wire, at excitation coil coaxial with induction coil of external placement.During stimulation, excitation coil produces pulsed magnetic field under the effect of the pulse current that is provided by stimulator, makes produce induction electromotive force in induction coil and form electric field on the nerve between two electrodes, thereby makes neural excitation.
Stimulator of the present invention utilizes the electric capacity of store electrical energy that excitation coil is discharged, and produces pulse current.By the adjustment to the stimulator parameter, realize the external control to the magnetic induction electrical stimulation effect.
Excitation coil of the present invention is formed by copper wire winding, and outer surface cover has insulation crust.Excitation coil under the effect of pulse current in its vicinity the space produce pulsed magnetic field.The inductive impact of excitation coil amplitude and the pulsewidth of pulsed magnetic field, and its size and shape has affected the distribution of magnetic field and induction field.
Induction coil of the present invention is made by the high conductivity material, and there is biocompatible materials (as silicones, Teflon, polyimides) parcel the outside, and its size is less, and diameter 10～30mm is simple in structure, has reduced the implantation risk, is easily accepted by the patient.Induction coil is used for receiving the external energy that is delivered in body, under the effect of pulsed magnetic field, the magnetic line of force that passes induction coil changes in time, according to Faraday law of electromagnetic induction, can produce induction electromotive force in induction coil, this induction electromotive force can be used as the stimulus of nerve stimulation, and need not built-in power.In addition, fixedly the time, induction electromotive force E is determined by the distance between two coils, rather than the distance between nerve and excitation coil when two coil shapes, the distance that this just is equivalent to further between nerve and excitation coil has solved the problem that direct magnetic stimulates depth as shallow; Induction electromotive force is the loop integral of induction field on induction coil in addition, and its effect is that the energy that magnetic stimulate to disperse is focused on stimulating electrode two ends, has improved the focusing that direct magnetic stimulates.
Stimulating electrode one end of the present invention is connected with induction coil, and the other end contacts with nerve, when producing induction electromotive force in induction coil, can produce electric field on the nerve between two electrodes.When this electric field is enough large, just can make neural excitation.
Description of drawings
Fig. 1 is the schematic diagram of magnetic induction electrical stimulation, in figure: 1 stimulator, 2 excitation coils, 3 induction coils, 4 stimulating electrodes, 5 spinal columns, the wire between 6 stimulators and excitation coil;
Fig. 2 is the work process block diagram of magnetic induction electrical stimulation device.
The specific embodiment
Further illustrate the present invention below in conjunction with the drawings and specific embodiments.
Explanation the specific embodiment of the present invention, as shown in Figure 1, the present invention includes stimulator 1, excitation coil 2, induction coil 3, stimulating electrode 4 as an example of the magnetic induction electrical stimulation of spinal cord example.Induction coil 3 diameter 10～30mm, be positioned at patient body, be connected with stimulating electrode 4, stimulating electrode 4 is fixed on spinal column 5, can make intravertebral spinal cord excited during stimulation, excitation coil 2 is positioned at outside patient body, and is coaxial with induction coil 3, and the distance between excitation coil 2 and induction coil 3 is between 10～30mm.Stimulator 1 is placed near the patient, for excitation coil 2 provides pulse current, connects stimulator and excitation coil by wire 6.
The circuit model of stimulator 1 is the RLC charging and discharging circuit, and high-voltage DC power supply charges to initial voltage V0 to capacitor C; After charging was completed, L discharged to coil.Make α=R/2L, wherein R is coil resistance, (α in the underdamping situation
2-1/LC＜0), the electric current in coil is:
ω wherein
2=1/ (LC)-α
2, during practical application, only having kept first posivtive spike of current waveform, its pulsewidth is T
p=π/ω, it is worth below 0.5ms.
The inductance of excitation coil is determined by its shape, can be expressed as:
N, d are respectively the number of turn and the average diameter of coil, and ψ is the parameter relevant with coil shape, can table look-up to obtain in relevant reckoner.Convolution (2) and formula (3) are optimized the shape of coil.Excitation coil is in the arbitrfary point, space
The vector magnetic potential that produces is:
Wherein:
K (k) and E (k) are respectively the first kind and complete elliptic integral of the second kind, a
iBe the radius of i circle coil, N is coil turn,
For
Unit vector on direction.
Induction coil 3 is made by the high conductivity material, and skin has the biocompatible materials parcel, with the coaxial placement of excitation coil.Under the effect of pulsed magnetic field, the magnetic line of force that passes induction coil changes in time, according to Faraday law of electromagnetic induction, can produce induction electromotive force in induction coil, and its value is the integration along induction coil direction inductor electric field E.Ignore the impact of surperficial stored charge, radius is that the induction electromotive force in the induction coil of b is:
By formula (4)-(6) as seen, when two coil shapes fixedly the time, induction electromotive force E determines by the distance between two coils, the distance between enclosing before this just be equivalent to further neural and excitation; Induction electromotive force is the loop integral of induction field on induction coil in addition, and its result is equivalent to concentrating in together with the induction field on Radius, thereby stimulates the energy that disperses will focus on stimulating electrode two ends magnetic.
Stimulating electrode 4 one ends are connected with induction coil, and the other end contacts with nerve, when producing induction electromotive force E in induction coil, can produce electric field on the nerve between two electrodes.If E is enough large, just can make neural excitation.
Work process of the present invention is as follows:
The explanation work process of the present invention as an example of the magnetic induction electrical stimulation of spinal cord example, as shown in Figure 2, at first by Operation induction coil and stimulating electrode, stimulating electrode is fixed on spinal cord, the induction coil that is connected with electrode is fixed on subcutaneous, induction coil and back plane parallel.During stimulation, according to the electrophysiological characteristics of spinal cord, select the excitation coil of suitable inductance and be connected on stimulator.Excitation coil is attached to patient body-surface, with the coaxial placement of induction coil, and the distance 10～30mm between two coils.The charging voltage that electric capacity in stimulator is set is a smaller value, begins to stimulate and observe effect of stimulation.Strengthen gradually afterwards stimulus intensity, until the patient produces muscle contraction, reach effect of stimulation.
Claims (1)
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200810224171 CN101391131B (en) | 2008-10-24 | 2008-10-24 | Nervous system magnetic induction electrical stimulation device |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200810224171 CN101391131B (en) | 2008-10-24 | 2008-10-24 | Nervous system magnetic induction electrical stimulation device |
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| CN101391131A CN101391131A (en) | 2009-03-25 |
| CN101391131B true CN101391131B (en) | 2013-05-15 |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102091382B (en) * | 2010-12-08 | 2013-10-23 | 中国科学院电工研究所 | An inductive electrical stimulator that promotes nerve regeneration |
| CN106267577B (en) * | 2015-06-24 | 2018-12-04 | 杜鸿业 | Micro light stimulation system suitable for being implanted into body |
| CN106124564A (en) * | 2016-07-25 | 2016-11-16 | 中国科学院电工研究所 | A kind of exsomatizednerve degree of tissue damage detection device |
| CN111939473A (en) * | 2020-08-28 | 2020-11-17 | 科斗（苏州）脑机科技有限公司 | A device for radio stimulation-induced neurorehabilitation and regeneration |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1721014A (en) * | 2004-06-24 | 2006-01-18 | 伊西康内外科公司 | Low frequency transcutaneous energy transfer to implanted medical device |
| CN1723056A (en) * | 2002-12-12 | 2006-01-18 | 梅廷·图尔加 | Externally Activated Neural Implants Directly Transmitting Therapeutic Signals |
| CN1721013A (en) * | 2004-06-24 | 2006-01-18 | 伊西康内外科公司 | Medical implant with closed loop percutaneous energy transfer power transfer regulation circuit |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US20050154426A1 (en) * | 2002-05-09 | 2005-07-14 | Boveja Birinder R. | Method and system for providing therapy for neuropsychiatric and neurological disorders utilizing transcranical magnetic stimulation and pulsed electrical vagus nerve(s) stimulation |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1723056A (en) * | 2002-12-12 | 2006-01-18 | 梅廷·图尔加 | Externally Activated Neural Implants Directly Transmitting Therapeutic Signals |
| CN1721014A (en) * | 2004-06-24 | 2006-01-18 | 伊西康内外科公司 | Low frequency transcutaneous energy transfer to implanted medical device |
| CN1721013A (en) * | 2004-06-24 | 2006-01-18 | 伊西康内外科公司 | Medical implant with closed loop percutaneous energy transfer power transfer regulation circuit |
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